CA2524271A1 - Controlled release bioactive agent delivery device - Google Patents

Controlled release bioactive agent delivery device Download PDF

Info

Publication number
CA2524271A1
CA2524271A1 CA002524271A CA2524271A CA2524271A1 CA 2524271 A1 CA2524271 A1 CA 2524271A1 CA 002524271 A CA002524271 A CA 002524271A CA 2524271 A CA2524271 A CA 2524271A CA 2524271 A1 CA2524271 A1 CA 2524271A1
Authority
CA
Canada
Prior art keywords
body member
bioactive agent
meth
acrylate
coated composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002524271A
Other languages
French (fr)
Other versions
CA2524271C (en
Inventor
Aron B. Anderson
Laurie R. Lawin
Byron C. Shen
Eugene De Juan
Signe E. Varner
Ralph A. Chappa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics Inc
Original Assignee
Surmodics, Inc.
Aron B. Anderson
Laurie R. Lawin
Byron C. Shen
Eugene De Juan
Signe E. Varner
Ralph A. Chappa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics, Inc., Aron B. Anderson, Laurie R. Lawin, Byron C. Shen, Eugene De Juan, Signe E. Varner, Ralph A. Chappa filed Critical Surmodics, Inc.
Publication of CA2524271A1 publication Critical patent/CA2524271A1/en
Application granted granted Critical
Publication of CA2524271C publication Critical patent/CA2524271C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00353—Bone cement, e.g. polymethylmethacrylate or PMMA

Abstract

The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides the use of said composition for the manufacture of a medicament for delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.

Claims (44)

1. A controlled release bioactive agent delivery device comprising:
a. a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and b. a polymeric coated composition in contact with the body member, the polymeric coated composition comprising a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises polyethylene-co-vinyl acetate).
2. The device according to claim 1 wherein the body member is coil-shaped.
3. The device according to claim 1 wherein the body member is spiral.
4. The device according to claim 1 wherein the body member is fabricated from twisted wire.
5. The device according to claim 1 wherein the body member includes surface configurations.
6. The device according to claim 5 wherein the body member has a roughened surface.
7. The device according to claim 1 wherein the body member is a threaded shaft.
8. The device according to claim 1 wherein a cap is positioned at the proximal end of the body member.
9. The device according to claim 1 wherein the body member includes a lumen.
10. The device according to claim 9 wherein the polymeric coated composition is provided entirely within the lumen of the body member.
11. The device according to claim 10 wherein a second polymeric coated composition is provided in contact with an external surface of the body member.
12. The device according to claim 11 wherein the second polymeric coated composition comprises a bioactive agent.
13. The device according to claim 12 wherein the bioactive agent of the second polymeric coated composition is different from the bioactive agent of the polymeric coated composition within the lumen.
14. The device according to claim 12 wherein the bioactive agent of the second polymeric coated composition is the same as the bioactive agent of the polymeric coated composition within the lumen.
15. The device according to claim 9 wherein the lumen includes a substance, and wherein the polymeric coated composition is in contact with an external surface of the body member.
16. The device according to claim 15 wherein the substance is the same as the bioactive agent of the polymeric coated composition.
17. The device according to claim 15 wherein the substance is different from the bioactive agent of the polymeric coated composition.
18. The device according to claim 1 wherein the first polymer comprises polyalkyl(meth)acrylate selected from the group consisting of polyalkyl(meth)acrylates having alkyl chain lengths in the range of 2 to 8 carbons.
19. The device according to claim 18 wherein the first polymer comprises poly(n-butyl)methacrylate.
20. The device according to claim 1 wherein the first polymer comprises aromatic poly(meth)acrylate selected from the group consisting of polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, and polyaryloxyalkyl(meth)acrylate.
21. The device according to claim 20 wherein the aromatic poly(meth)acrylate comprises aryl groups having from 6 to 16 carbon atoms.
22. The device according to claim 1 wherein the polyethylene-co-vinyl acetate) has a vinyl acetate concentration in the range of 10% to 90% by weight.
23. The device according to claim 1 wherein the polymeric coated composition comprises two or more layers on the body member.
24. The device according to claim 1 or claim 23 further comprising a surface pretreatment.
25. The device according to claim 24 wherein the surface pretreatment is selected from the group consisting of silane, polyurethane, parylene, or combinations thereof.
26. The device according to claim 1 wherein the bioactive agent is selected from the group consisting of triamcinolone acetonide, 13-cis retinoic acid, 5-fluorouridine, and combinations thereof.
27. The device according to claim 1 wherein the bioactive agent is present in an amount in the range of 1 µg to 10 mg of bioactive agent per cm2 of the effective surface area of the device.
28. The device according to claim 1 wherein the bioactive agent is present in an amount of 75% by weight or less of the polymeric coated composition.
29. The device according to claim 1 wherein the bioactive agent is released in a therapeutically effective amount when implanted in a patient.
30. The device according to claim 1 wherein the bioactive agent is released in a therapeutically effective amount for a period of 6 months or more when implanted in a patient.
31. The device according to claim 26 wherein the bioactive agent is triamcinolone acetonide, and the triamcinolone acetonide has a release rate in the range of 0.5 µg/day to 2 µg/day when implanted in an eye.
32. The device according to claim 1 wherein the bioactive agent is present in an amount in the range of 1 µg to 5 mg in the polymeric coated composition.
33. The device according to claim 1 wherein the polymeric coated composition has a final coating thickness in the range of 0.1 µm to 100 µm when provided on an external surface of the body member.
34. The device according to claim 1 wherein the distal end of the body member is positioned at the longitudinal axis.
35. The device according to claim 1 wherein the distal end of the body member is spaced from the longitudinal axis.
36. The device according to claim 1 wherein the proximal end of the body member is positioned at the longitudinal axis.
37. The device according to claim 1 wherein the polymeric coated composition is provided with a stepped configuration towards the distal end of the body member.
38. The device according to claim 37 wherein the stepped configuration comprises a tapered configuration towards the distal end of the body member.
39. A method of delivering a bioactive agent to a patient comprising:
a. providing a controlled release bioactive agent delivery device according to any one of claims 1 through 38, b. inserting the device into a patient's body, and c. removing the device from the patient's body once a therapeutically effective amount of bioactive agent has been delivered to the patient.
40. The method according to claim 39 wherein the step of inserting the device into a patient's body comprises inserting the device into an eye of the patient.
41. A method of making a controlled release bioactive agent delivery device comprising:
a. providing a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and b. providing a polymeric coating composition comprising a first polymer, a second polymer, and a bioactive agent in contact with the body member, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises polyethylene-co-vinyl acetate).
42. The method according to claim 41 wherein the step of providing a polymeric coating composition in contact with the body member comprises providing the polymeric coating composition on an external surface of the body member.
43. The method according to claim 41 wherein the body member includes a lumen, and wherein the step of providing a polymeric coating composition in contact with the body member comprises providing the polymeric coating composition in the lumen.
44. The method according to any one of claims 41-43 wherein the step of providing a polymeric coating composition in contact with the body member comprises providing the polymeric coating under controlled humidity conditions.
CA2524271A 2003-05-02 2004-04-29 Controlled release bioactive agent delivery device Expired - Fee Related CA2524271C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46741903P 2003-05-02 2003-05-02
US60/467,419 2003-05-02
PCT/US2004/013327 WO2004098565A2 (en) 2003-05-02 2004-04-29 Implantable controlled release bioactive agent delivery device

Publications (2)

Publication Number Publication Date
CA2524271A1 true CA2524271A1 (en) 2004-11-18
CA2524271C CA2524271C (en) 2012-09-04

Family

ID=33435072

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2524271A Expired - Fee Related CA2524271C (en) 2003-05-02 2004-04-29 Controlled release bioactive agent delivery device

Country Status (8)

Country Link
US (7) US8021680B2 (en)
EP (1) EP1633320A2 (en)
JP (3) JP4824549B2 (en)
AT (1) ATE476960T1 (en)
AU (1) AU2004237774B2 (en)
CA (1) CA2524271C (en)
DE (1) DE602004028638D1 (en)
WO (1) WO2004098565A2 (en)

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713297B2 (en) * 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
WO1999055396A1 (en) * 1998-04-27 1999-11-04 Surmodics, Inc. Bioactive agent release coating
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US7727221B2 (en) 2001-06-27 2010-06-01 Cardiac Pacemakers Inc. Method and device for electrochemical formation of therapeutic species in vivo
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
ATE476960T1 (en) * 2003-05-02 2010-08-15 Surmodics Inc SYSTEM FOR THE CONTROLLED RELEASE OF A BIOACTIVE INGREDIENT IN THE BACK OF THE EYE
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
JP4732346B2 (en) * 2003-08-19 2011-07-27 バイエル・マテリアルサイエンス・アクチェンゲゼルシャフト Polymeric drug elution system for medical devices
US20080206308A1 (en) * 2003-08-29 2008-08-28 Esmaiel Jabbari Hydrogel Porogents for Fabricating Biodegradable Scaffolds
US7598313B2 (en) * 2003-09-05 2009-10-06 University Of Massachusetts Amphiphilic polymer capsules and related methods of interfacial assembly
US7976520B2 (en) * 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US20050222613A1 (en) * 2004-02-05 2005-10-06 Edwin Ryan Wound closure device and method for vitrectomy
CN1964748A (en) * 2004-04-06 2007-05-16 苏莫迪克斯公司 Coating compositions for bioactive agents
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US7758892B1 (en) * 2004-05-20 2010-07-20 Boston Scientific Scimed, Inc. Medical devices having multiple layers
US20060024350A1 (en) * 2004-06-24 2006-02-02 Varner Signe E Biodegradable ocular devices, methods and systems
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
DK1765454T3 (en) * 2004-07-02 2016-05-02 Mati Therapeutics Inc Device for submission of treatment medium to eye
WO2006078320A2 (en) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
WO2006023130A2 (en) * 2004-08-12 2006-03-02 Surmodics, Inc. Biodegradable controlled release bioactive agent delivery device
CA2587308A1 (en) 2004-11-12 2006-05-18 Mayo Foundation For Medical Education And Research Photocrosslinkable poly(caprolactone fumarate)
US20060134168A1 (en) 2004-12-07 2006-06-22 Chappa Ralph A Coatings with crystallized active agent(s) and methods
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US20060198868A1 (en) * 2005-01-05 2006-09-07 Dewitt David M Biodegradable coating compositions comprising blends
US20060147491A1 (en) * 2005-01-05 2006-07-06 Dewitt David M Biodegradable coating compositions including multiple layers
JP4907643B2 (en) * 2005-03-07 2012-04-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Medical implant
CA2563253A1 (en) * 2005-04-06 2006-10-12 Surmodics, Inc. Bioactive coating compositions for medical devices
US20060228390A1 (en) * 2005-04-07 2006-10-12 Williams David F Intravitreal implant
CN101180086A (en) * 2005-04-08 2008-05-14 苏尔莫迪克斯公司 Sustained release implants for subretinal delivery
WO2006118987A1 (en) * 2005-04-29 2006-11-09 Mayo Foundation For Medical Education And Research Hydrophilic/hydrophobic polymer networks based on poly(caprolactone fumarate), poly(ethylene glycol fumarate), and copolymers thereof
EP1895957A1 (en) * 2005-05-18 2008-03-12 SurModics, Inc. Insertion instrument for non-linear medical devices
US20070038176A1 (en) * 2005-07-05 2007-02-15 Jan Weber Medical devices with machined layers for controlled communications with underlying regions
US7833463B1 (en) * 2005-07-18 2010-11-16 Advanced Neuromodulation Systems, Inc. System and method for removing an organic film from a selected portion of an implantable medical device using an infrared laser
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
ATE449618T1 (en) * 2005-08-18 2009-12-15 Zimmer Gmbh ULTRA HIGH MOLECULAR POLYETHYLENE ARTICLES AND METHOD FOR PRODUCING ULTRA HIGH MOLECULAR POLYETHYLENE ARTICLES
ES2380651T3 (en) * 2005-09-01 2012-05-17 Bristol-Myers Squibb Company Biomarkers and procedures to determine the sensitivity to modulators of reciprocator 2 of vascular endothelial growth factor
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
JP5139301B2 (en) * 2005-09-21 2013-02-06 サーモディクス，インコーポレイティド Coatings and devices containing biodegradable natural polysaccharides
EP1926504B1 (en) * 2005-09-21 2010-01-13 SurModics, Inc. In situ occluding compositions ncluding natural biodegradable polysaccharides
WO2007059144A1 (en) * 2005-11-15 2007-05-24 Surmodics, Inc. Ultrasonic nozzles for applying two-component coatings
US8840660B2 (en) * 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
CA2636716C (en) * 2006-01-13 2014-12-23 Surmodics, Inc. Microparticle containing matrices for drug delivery
WO2007084582A2 (en) * 2006-01-17 2007-07-26 Forsight Labs, Llc Drug delivery treatment device
EP3632385A1 (en) 2006-01-17 2020-04-08 Novartis AG Glaucoma treatment device
US8089029B2 (en) * 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
CA2645324A1 (en) * 2006-03-15 2007-09-27 Surmodics, Inc. Hydrophobic derivatives of natural biodegradable polysaccharides and uses thereof
US20070224244A1 (en) * 2006-03-22 2007-09-27 Jan Weber Corrosion resistant coatings for biodegradable metallic implants
US20070224235A1 (en) * 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) * 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
DK2010096T3 (en) 2006-03-31 2017-10-02 Mati Therapeutics Inc NASOLACRIMAL DRAINAGE SYSTEM IMPLANTS FOR PHARMACEUTICAL THERAPY
US8048150B2 (en) * 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US20070264303A1 (en) * 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
US9474645B2 (en) * 2006-06-21 2016-10-25 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US7638344B2 (en) * 2006-06-28 2009-12-29 Surmodics, Inc. Active agent eluting matrices with particulates
US8968782B2 (en) * 2006-06-28 2015-03-03 Surmodics, Inc. Combination degradable and non-degradable matrices for active agent delivery
CA2655793A1 (en) * 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
JP2009545407A (en) 2006-08-02 2009-12-24 ボストン サイエンティフィック サイムド，インコーポレイテッド End prosthesis with 3D decomposition control
US20080171087A1 (en) * 2006-08-16 2008-07-17 Chappa Ralph A Methods and materials for increasing the adhesion of elution control matrices to substrates
JP2010503469A (en) 2006-09-14 2010-02-04 ボストン サイエンティフィック リミテッド Medical device having drug-eluting film
DE602007011114D1 (en) 2006-09-15 2011-01-20 Boston Scient Scimed Inc BIODEGRADABLE ENDOPROTHESIS WITH BIOSTABILES INORGANIC LAYERS
WO2008034066A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
WO2008034013A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
JP2010503489A (en) * 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド Biodegradable endoprosthesis and method for producing the same
WO2008036548A2 (en) * 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
WO2008036457A2 (en) * 2006-09-18 2008-03-27 Boston Scientific Limited Controlling biodegradation of a medical instrument
WO2008039749A2 (en) * 2006-09-25 2008-04-03 Surmodics, Inc. Multi-layered coatings and methods for controlling elution of active agents
WO2008088593A2 (en) * 2006-09-27 2008-07-24 Surmodics, Inc. Additives and methods for enhancing active agent elution kinetics
EP2068828A2 (en) * 2006-09-29 2009-06-17 SurModics, Inc. Biodegradable ocular implants and methods for treating ocular conditions
WO2008045184A1 (en) * 2006-10-05 2008-04-17 Boston Scientific Limited Polymer-free coatings for medical devices formed by plasma electrolytic deposition
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
ES2506144T3 (en) * 2006-12-28 2014-10-13 Boston Scientific Limited Bioerodible endoprosthesis and their manufacturing procedure
UY30883A1 (en) 2007-01-31 2008-05-31 Alcon Res PUNCTURAL PLUGS AND METHODS OF RELEASE OF THERAPEUTIC AGENTS
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
FR2915087B1 (en) 2007-04-20 2021-11-26 Corevalve Inc IMPLANT FOR TREATMENT OF A HEART VALVE, IN PARTICULAR OF A MITRAL VALVE, EQUIPMENT INCLUDING THIS IMPLANT AND MATERIAL FOR PLACING THIS IMPLANT.
US7976915B2 (en) * 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8002823B2 (en) * 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2173289A4 (en) * 2007-07-17 2010-11-24 Transcend Medical Inc Ocular implant with hydrogel expansion capabilities
WO2009012353A2 (en) 2007-07-19 2009-01-22 Boston Scientific Limited Endoprosthesis having a non-fouling surface
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8815273B2 (en) * 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
WO2009018340A2 (en) * 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
JP2010535541A (en) * 2007-08-03 2010-11-25 ボストン サイエンティフィック リミテッド Coating for medical devices with large surface area
EP2865361B1 (en) 2007-09-07 2019-05-22 Mati Therapeutics Inc. Lacrimal implants and related methods
SG184727A1 (en) * 2007-09-07 2012-10-30 Quadra Logic Tech Inc Insertion and extraction tools for lacrimal implants
SG184728A1 (en) 2007-09-07 2012-10-30 Quadra Logic Tech Inc Lacrimal implant detection
WO2009035562A2 (en) 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Drug cores for sustained release of therapeutic agents
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US20090214601A1 (en) * 2007-09-28 2009-08-27 Chappa Ralph A Porous Drug Delivery Devices and Related Methods
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US20090118809A1 (en) * 2007-11-02 2009-05-07 Torsten Scheuermann Endoprosthesis with porous reservoir and non-polymer diffusion layer
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8029554B2 (en) * 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US20090143855A1 (en) * 2007-11-29 2009-06-04 Boston Scientific Scimed, Inc. Medical Device Including Drug-Loaded Fibers
WO2009079389A2 (en) * 2007-12-14 2009-06-25 Boston Scientific Limited Drug-eluting endoprosthesis
ES2718612T3 (en) 2007-12-20 2019-07-03 Evonik Corp Procedure for preparing microparticles that have a low volume of residual solvent
US8167787B2 (en) 2008-01-03 2012-05-01 Revent Medical, Inc. Partially erodable systems for treatment of obstructive sleep apnea
US20090186059A1 (en) * 2008-01-14 2009-07-23 Johnson Elizabeth E Devices and methods for elution of nucleic acid delivery complexes
JP2011510750A (en) 2008-01-29 2011-04-07 クライマン、ギルバート・エイチ Drug delivery device, kit and methods thereof
EP2254536A2 (en) * 2008-02-18 2010-12-01 QLT Plug Delivery, Inc. Lacrimal implants and related methods
WO2009126830A2 (en) * 2008-04-09 2009-10-15 Surmodics, Inc. Delivery of nucleic acid complexes from materials including negatively charged groups
WO2009128944A2 (en) * 2008-04-18 2009-10-22 Surmodics, Inc. Coating systems for the controlled delivery of hydrophilic bioactive agents
EP2271380B1 (en) 2008-04-22 2013-03-20 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
WO2009134371A2 (en) 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Composite lacrimal insert and related methods
US8936811B2 (en) * 2008-05-07 2015-01-20 Surmodics, Inc. Device coated with glycogen particles comprising nucleic acid complexes
US7998192B2 (en) * 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
CN102123713A (en) * 2008-05-09 2011-07-13 Qlt栓塞输送公司 Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US8707960B2 (en) 2008-05-12 2014-04-29 Revent Medical, Inc. Partially erodable systems for treatment of obstructive sleep apnea
US9439801B2 (en) 2012-06-29 2016-09-13 Revent Medical, Inc. Systems and methods for treatment of sleep apnea
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20100004733A1 (en) * 2008-07-02 2010-01-07 Boston Scientific Scimed, Inc. Implants Including Fractal Structures
US8459310B2 (en) * 2008-07-24 2013-06-11 Surmodics, Inc. Systems and methods for filling medical device lumen
US7985252B2 (en) * 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) * 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
RU2673882C1 (en) 2008-10-30 2018-12-03 Грюненталь Гмбх New and effective medicinal forms of tapentadol
US10272035B2 (en) 2008-11-13 2019-04-30 Gholam A. Peyman Ophthalmic drug delivery method
US10842669B2 (en) 2008-11-13 2020-11-24 Gholam A. Peyman Ophthalmic drug delivery method
US20110125090A1 (en) * 2008-11-13 2011-05-26 Peyman Gholam A Ophthalmic drug delivery system and method
EP2367527A2 (en) 2008-11-26 2011-09-28 SurModics, Inc. Implantable ocular drug delivery device and methods
US8231980B2 (en) * 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
CA2757037C (en) 2009-01-29 2019-08-06 Forsight Vision4, Inc. Posterior segment drug delivery
US20100191168A1 (en) * 2009-01-29 2010-07-29 Trustees Of Tufts College Endovascular cerebrospinal fluid shunt
BRPI1008030A2 (en) * 2009-02-23 2016-03-15 Qlt Plug Delivery Inc tear implants and related methods
EP2403546A2 (en) * 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) * 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) * 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US20100274352A1 (en) * 2009-04-24 2010-10-28 Boston Scientific Scrimed, Inc. Endoprosthesis with Selective Drug Coatings
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US20100303878A1 (en) 2009-06-02 2010-12-02 Joram Slager Biodegradable bioactive agent releasing matrices with particulates
JP5695035B2 (en) 2009-06-03 2015-04-01 フォーサイト・ビジョン５・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ５，Ｉｎｃ． Anterior eye drug supply
US8586731B2 (en) * 2009-06-11 2013-11-19 Surmodics, Inc. Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation
US20110022158A1 (en) * 2009-07-22 2011-01-27 Boston Scientific Scimed, Inc. Bioerodible Medical Implants
WO2011014704A2 (en) 2009-07-30 2011-02-03 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
CN102811705A (en) * 2009-09-22 2012-12-05 赢创德固赛公司 Implant Devices Having Varying Bioactive Agent Loading Configurations
EP2482863A1 (en) * 2009-09-30 2012-08-08 SurModics, Inc. Hydrophobic polysaccharides with silyl ether linkages having enhanced degradation and medical articles made therefrom
US20110166555A1 (en) * 2009-09-30 2011-07-07 Jianbo Zhou Carrier for an insertable medical device, insertion tools, methods of use, and kits
US9549842B2 (en) 2011-02-04 2017-01-24 Joseph E. Kovarik Buccal bioadhesive strip and method of treating snoring and sleep apnea
US8701671B2 (en) 2011-02-04 2014-04-22 Joseph E. Kovarik Non-surgical method and system for reducing snoring
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US8568760B2 (en) * 2009-12-30 2013-10-29 Surmodics, Inc. Hydrophobic polysaccharides with pendent groups having terminal reactive functionalities and medical uses thereof
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
EP2547297A4 (en) 2010-03-19 2014-08-06 Revent Medical Inc Systems and methods for treatment of sleep apnea
EP2547296A4 (en) 2010-03-19 2014-08-06 Revent Medical Inc Systems and methods for treatment of sleep apnea
US8668732B2 (en) * 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
JP2013526392A (en) 2010-05-21 2013-06-24 レベント メディカル インコーポレイテッド System and method for treating sleep apnea
CA2806724A1 (en) 2010-07-26 2012-02-09 Revent Medical, Inc. Systems and methods for treatment of sleep apnea
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
RS61601B1 (en) 2010-08-05 2021-04-29 Forsight Vision4 Inc Injector apparatus for drug delivery
RS62540B1 (en) 2010-08-05 2021-12-31 Forsight Vision4 Inc Apparatus to treat an eye
US20120100187A1 (en) 2010-10-26 2012-04-26 Surmodics, Inc. Coatings and methods for controlled elution of hydrophilic active agents
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP2726016B1 (en) 2011-06-28 2023-07-19 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
JP6100782B2 (en) 2011-08-29 2017-03-22 キューエルティー インコーポレイテッド Slow broadcast of active agents to treat glaucoma and ocular hypertension
WO2013040426A2 (en) 2011-09-14 2013-03-21 Forsight Labs, Llc Ocular insert apparatus and methods
EP2755546A4 (en) * 2011-09-15 2015-08-12 Yoseph Yaacobi Systems and methods for treating ear disorders
WO2013040247A2 (en) 2011-09-16 2013-03-21 Forsight Vision4, Inc. Fluid exchange apparatus and methods
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US20150031772A1 (en) * 2012-02-17 2015-01-29 Bacterin International, Inc. Adjustable bioactive agent dispersion within a polymeric coating
US10085633B2 (en) 2012-04-19 2018-10-02 Novartis Ag Direct visualization system for glaucoma treatment
US9241832B2 (en) 2012-04-24 2016-01-26 Transcend Medical, Inc. Delivery system for ocular implant
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
JP6549482B2 (en) 2012-06-01 2019-07-24 サーモディクス，インコーポレイテッド Device and method for coating a balloon catheter
US9078743B2 (en) * 2012-08-22 2015-07-14 California Institute Of Technology 3-coil wireless power transfer system for eye implants
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
WO2014066775A1 (en) 2012-10-26 2014-05-01 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
US9763829B2 (en) 2012-11-14 2017-09-19 Novartis Ag Flow promoting ocular implant
CA2905496A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
AU2014241163B2 (en) 2013-03-28 2018-09-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
AU2014256955B2 (en) 2013-04-25 2018-02-22 Innovative Surface Technologies, Inc. Coatings for controlled release of highly water soluble drugs
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
EP3998100A1 (en) 2014-01-15 2022-05-18 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt system
US9737696B2 (en) 2014-01-15 2017-08-22 Tufts Medical Center, Inc. Endovascular cerebrospinal fluid shunt
AU2015229947A1 (en) 2014-03-12 2016-10-27 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
WO2015184173A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
JP2017527329A (en) 2014-07-01 2017-09-21 インジェクトセンス， インコーポレイテッド Hermetic sealed implant sensor with vertical stacking structure
WO2016004223A1 (en) * 2014-07-01 2016-01-07 Cao Ariel Methods and devices for implantation of intraocular pressure sensors
WO2016011191A1 (en) 2014-07-15 2016-01-21 Forsight Vision4, Inc. Ocular implant delivery device and method
SG11201700943TA (en) 2014-08-08 2017-03-30 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
CA2967330A1 (en) 2014-11-10 2016-05-19 Forsight Vision4, Inc. Expandable drug delivery devices and methods of use
CA2969751C (en) 2014-12-03 2020-09-22 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
US10457832B2 (en) * 2015-05-21 2019-10-29 Toyo Seikan Group Holdings, Ltd. Surface-treated metal sheet and organic resin-covered surface-treated metal sheet
EP3319553B1 (en) * 2015-08-14 2024-01-31 Willis, Timothy R. Intraocular lenses (iols) and related assemblies
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
CN113069681B (en) 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 Method of manufacturing a therapeutic device for sustained drug delivery
US10744233B2 (en) 2016-02-24 2020-08-18 Innovative Surface Technologies, Inc. Crystallization inhibitor compositions for implantable urological devices
US10065018B2 (en) 2016-03-16 2018-09-04 Krishna Rocha-Singh Apparatus and method for promoting angiogenesis in ischemic tissue
US10610669B2 (en) 2016-03-16 2020-04-07 Krishna Rocha-Singh, M.D. Apparatus and method for promoting angiogenesis in ischemic tissue
ES2837524T3 (en) 2016-04-05 2021-06-30 Forsight Vision4 Inc Implantable ocular drug delivery devices
WO2017184881A1 (en) 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
EP3468650B1 (en) 2016-06-09 2020-07-15 Boston Scientific Scimed, Inc. Infusion catheter
CA3039653A1 (en) * 2016-10-05 2018-04-12 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for augmenting immune system responses
KR102460406B1 (en) 2016-11-03 2022-10-31 아리조나 보드 오브 리전츠 온 비해프 오브 더 유니버시티 오브 아리조나 Layered Tissue Encapsulation Device Systems with or Without Oxygen Delivery
EP3534834A4 (en) 2016-11-03 2020-05-13 Arizona Board of Regents on behalf of the University of Arizona Encapsulation device systems with oxygen sensors with or without exogenous oxygen delivery
WO2018144099A1 (en) 2016-11-03 2018-08-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre-and post-transplantation
CN111655206B (en) 2017-11-21 2022-10-14 弗赛特影像4股份有限公司 Fluid exchange device for expandable port delivery system and method of use
US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
BR112020023983A2 (en) 2018-05-24 2021-02-23 Celanese Eva Performance Polymers Llc implantable device for prolonged release of a macromolecular drug compound
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
US11338119B2 (en) * 2020-03-20 2022-05-24 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11173291B2 (en) 2020-03-20 2021-11-16 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11344526B2 (en) 2020-03-20 2022-05-31 The Regents Of The University Of California Implantable drug delivery devices for localized drug delivery
US11246682B1 (en) * 2020-11-09 2022-02-15 Elliott Jolley Systems and methods for providing an orthodontic spring

Family Cites Families (225)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US22853A (en) * 1859-02-08 John l
US120174A (en) * 1871-10-24 Improvement in feather-renovators
US21828A (en) * 1858-10-19 Perry g
US14036A (en) * 1856-01-01 Improvement in grain-binders for harvesters
US47911A (en) * 1865-05-30 Improvement in waxed-thread sewing-machines
US273410A (en) 1883-03-06 Gelatine eye-disk
US188037A (en) * 1877-03-06 Improvement in suspension hooks and clasps
US198511A (en) * 1877-12-25 Improvement in harness-saddles
US32434A (en) * 1861-05-28 Improvement in animal-traps
US114823A (en) * 1871-05-16 Improvement in presser-feet for sewing-machines
US158598A (en) * 1875-01-12 Improvement in culinary vessels
US168394A (en) * 1875-10-05 Improvement in children s carriages
US165265A (en) * 1875-07-06 Improvement in table-leaf lifters and supporters
US26176A (en) * 1859-11-22 Sawmill
US31780A (en) * 1861-03-26 Device for forming horseshoes
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US4000745A (en) 1968-08-05 1977-01-04 Goldberg Edward M Electrical leads for cardiac stimulators and related methods and means
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US4069307A (en) 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4144317A (en) 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4206756A (en) 1977-03-23 1980-06-10 Murray Grossan Jet ear irrigation system
US4146036A (en) 1977-10-06 1979-03-27 Medtronic, Inc. Body-implantable lead with protector for tissue securing means
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
US4209019A (en) 1979-01-05 1980-06-24 Medtronic, Inc. Stylet insertion guide and rotation control device for use with body implantable lead
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
US4304765A (en) 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4678466A (en) 1981-06-25 1987-07-07 Rosenwald Peter L Internal medication delivery method and vehicle
US5310559A (en) 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
US4892736A (en) 1983-10-07 1990-01-09 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
US4764377A (en) 1983-10-07 1988-08-16 The Forsyth Dental Infirmary For Children Intra-pocket drug delivery devices for treatment of periodontal diseases
GB8527071D0 (en) 1985-11-04 1985-12-11 Biocompatibles Ltd Plastics
US4959217A (en) 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US5229128A (en) 1986-06-11 1993-07-20 Haddad Heskel M Drug delivery ophthalmic insert and method of preparing same
US5989579A (en) 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US5114719A (en) 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US4819661A (en) 1987-10-26 1989-04-11 Cardiac Pacemakers, Inc. Positive fixation cardiac electrode with drug elution capabilities
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US4997652A (en) 1987-12-22 1991-03-05 Visionex Biodegradable ocular implants
US4936825A (en) 1988-04-11 1990-06-26 Ungerleider Bruce A Method for reducing intraocular pressure caused by glaucoma
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US6514238B1 (en) 1989-08-14 2003-02-04 Photogenesis, Inc. Method for preparation and transplantation of volute grafts and surgical instrument therefor
US4972848A (en) 1989-08-23 1990-11-27 Medtronic, Inc. Medical electrical lead with polymeric monolithic controlled release device and method of manufacture
US4953564A (en) 1989-08-23 1990-09-04 Medtronic, Inc. Screw-in drug eluting lead
US5003992A (en) 1989-08-23 1991-04-02 Holleman Timothy W Atraumatic screw-in lead
US5002067A (en) 1989-08-23 1991-03-26 Medtronic, Inc. Medical electrical lead employing improved penetrating electrode
US5255693A (en) 1989-11-02 1993-10-26 Possis Medical, Inc. Cardiac lead
US5525348A (en) 1989-11-02 1996-06-11 Sts Biopolymers, Inc. Coating compositions comprising pharmaceutical agents
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5076285A (en) 1990-03-30 1991-12-31 Medtronic, Inc. Screw-in lead
US5120312A (en) * 1990-04-20 1992-06-09 Regents Of The University Of Minnesota Method and apparatus for catheterization
AU7998091A (en) 1990-05-17 1991-12-10 Harbor Medical Devices, Inc. Medical device polymer
KR0185215B1 (en) 1990-11-30 1999-05-01 요시다 쇼오지 A controlled-release pharmaceutical preparation for intra-ocular implant
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5437656A (en) 1991-02-27 1995-08-01 Leonard Bloom Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment
AU1579092A (en) 1991-02-27 1992-10-06 Nova Pharmaceutical Corporation Anti-infective and anti-inflammatory releasing systems for medical devices
US5364343A (en) 1991-03-06 1994-11-15 D.D. S.R.L. Irrigation device for use in ear canals for therapeutic or hygienic purposes
US5324325A (en) 1991-06-27 1994-06-28 Siemens Pacesetter, Inc. Myocardial steroid releasing lead
US5221698A (en) 1991-06-27 1993-06-22 The Regents Of The University Of Michigan Bioactive composition
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5246867A (en) 1992-01-17 1993-09-21 University Of Maryland At Baltimore Determination and quantification of saccharides by luminescence lifetimes and energy transfer
JP3485320B2 (en) 1992-02-14 2004-01-13 スミス アンド ネフュー インコーポレーテッド Surgical polymer screws and coatings
US5599352A (en) 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
IT1259100B (en) 1992-05-20 1996-03-11 Lanfranco Callegaro USE OF HYDROGELS FOR THE LOCKING OF PROSTHETIC SYSTEMS
US5447533A (en) 1992-09-03 1995-09-05 Pacesetter, Inc. Implantable stimulation lead having an advanceable therapeutic drug delivery system
US5314419A (en) 1992-10-30 1994-05-24 Pelling George E Method for dispensing ophthalmic drugs to the eye
US5449382A (en) 1992-11-04 1995-09-12 Dayton; Michael P. Minimally invasive bioactivated endoprosthesis for vessel repair
US5578075B1 (en) 1992-11-04 2000-02-08 Daynke Res Inc Minimally invasive bioactivated endoprosthesis for vessel repair
EP0604022A1 (en) 1992-12-22 1994-06-29 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method for its manufacture
US5300108A (en) 1993-01-05 1994-04-05 Telectronics Pacing Systems, Inc. Active fixation lead with a dual-pitch, free spinning compound screw
US5523092A (en) * 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5673473A (en) * 1993-06-25 1997-10-07 Medtronic, Inc. Method of surface finishing a medical device shield using metallic media
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
CN100998869A (en) 1993-07-19 2007-07-18 血管技术药物公司 Anti-angiogene compositions and methods of use
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US5385148A (en) 1993-07-30 1995-01-31 The Regents Of The University Of California Cardiac imaging and ablation catheter
US5921982A (en) 1993-07-30 1999-07-13 Lesh; Michael D. Systems and methods for ablating body tissue
WO1995003843A1 (en) 1993-07-30 1995-02-09 The Regents Of The University Of California Endocardial infusion catheter
US5405376A (en) 1993-08-27 1995-04-11 Medtronic, Inc. Method and apparatus for ablation
US5807395A (en) 1993-08-27 1998-09-15 Medtronic, Inc. Method and apparatus for RF ablation and hyperthermia
US5431649A (en) 1993-08-27 1995-07-11 Medtronic, Inc. Method and apparatus for R-F ablation
US5423777A (en) 1993-10-27 1995-06-13 Tajiri; Akira Punctum plug
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US5849843A (en) 1993-11-16 1998-12-15 Baxter International Inc. Polymeric compositions for medical packaging and devices
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5472436A (en) 1994-07-26 1995-12-05 Fremstad; Daria A. Ocular appliance for delivering medication
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5582616A (en) 1994-08-05 1996-12-10 Origin Medsystems, Inc. Surgical helical fastener with applicator
US5554114A (en) 1994-10-20 1996-09-10 Micro Therapeutics, Inc. Infusion device with preformed shape
US5725493A (en) 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US5551427A (en) 1995-02-13 1996-09-03 Altman; Peter A. Implantable device for the effective elimination of cardiac arrhythmogenic sites
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
DE29624503U1 (en) 1995-04-19 2004-09-16 Boston Scientific Scimed, Inc. Drug-releasing coated stent
US20020091433A1 (en) 1995-04-19 2002-07-11 Ni Ding Drug release coated stent
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6120536A (en) 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
IL113723A (en) 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
US6117456A (en) 1995-05-19 2000-09-12 Etex Corporation Methods and products related to the physical conversion of reactive amorphous calcium phosphate
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5731087A (en) * 1995-06-07 1998-03-24 Union Carbide Chemicals & Plastics Technology Corporation Lubricious coatings containing polymers with vinyl and carboxylic acid moieties
US5877224A (en) 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US5810836A (en) 1996-03-04 1998-09-22 Myocardial Stents, Inc. Device and method for trans myocardial revascularization (TMR)
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
US20030094736A1 (en) 1996-05-03 2003-05-22 Chuan Qin Method of surface modifying a medical tubing
US6143037A (en) 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US5928662A (en) 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US6053924A (en) 1996-11-07 2000-04-25 Hussein; Hany Device and method for trans myocardial revascularization
US20030157187A1 (en) 1996-12-02 2003-08-21 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory diseases
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US5980972A (en) 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US5997517A (en) 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
US6086582A (en) 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
US6547787B1 (en) 1997-03-13 2003-04-15 Biocardia, Inc. Drug delivery catheters that attach to tissue and methods for their use
NZ500018A (en) 1997-03-31 2001-07-27 Alza Corp Diffusional implantable delivery system with capillary tube of cross-sectional area and length to deliver beneficial agent
EP0980273A1 (en) 1997-04-16 2000-02-23 White Spot AG Biodegradable osteosynthesis implant
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US6110483A (en) 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
JP2001513369A (en) 1997-08-11 2001-09-04 アラーガン・セイルズ・インコーポレイテッド Sterile bioerodible implant devices and methods with improved biocompatibility
US6214434B1 (en) * 1997-09-02 2001-04-10 Seagate Technology Llc Isolated single-domain high-density magnetic recording media and method of manufacturing the media
US5972027A (en) 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US5980548A (en) 1997-10-29 1999-11-09 Kensey Nash Corporation Transmyocardial revascularization system
US6501994B1 (en) 1997-12-24 2002-12-31 Cardiac Pacemakers, Inc. High impedance electrode tip
US6212434B1 (en) 1998-07-22 2001-04-03 Cardiac Pacemakers, Inc. Single pass lead system
US6197324B1 (en) 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
US6251418B1 (en) 1997-12-18 2001-06-26 C.R. Bard, Inc. Systems and methods for local delivery of an agent
US6221425B1 (en) 1998-01-30 2001-04-24 Advanced Cardiovascular Systems, Inc. Lubricious hydrophilic coating for an intracorporeal medical device
DE69838526T2 (en) 1998-02-05 2008-07-03 Biosense Webster, Inc., Diamond Bar Device for releasing a drug in the heart
EP0945148B1 (en) 1998-03-26 2003-11-26 Biomat B.V. Endovascular stents with a polymeric coating
US6091978A (en) 1998-04-07 2000-07-18 Cardiac Pacemakers, Inc. Removable cap for tissue-insertable connections
US20010029351A1 (en) 1998-04-16 2001-10-11 Robert Falotico Drug combinations and delivery devices for the prevention and treatment of vascular disease
WO1999055396A1 (en) * 1998-04-27 1999-11-04 Surmodics, Inc. Bioactive agent release coating
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US6263880B1 (en) 1998-06-22 2001-07-24 Neovasys, Inc. Method of enhancing blood flow in tissue
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
US6102887A (en) 1998-08-11 2000-08-15 Biocardia, Inc. Catheter drug delivery system and method for use
US6335029B1 (en) 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6290728B1 (en) 1998-09-10 2001-09-18 Percardia, Inc. Designs for left ventricular conduit
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
ES2247826T3 (en) 1998-09-29 2006-03-01 C.R. Bard Inc. MEDICINES ADMINISTRATION SYSTEMS.
US6248112B1 (en) 1998-09-30 2001-06-19 C. R. Bard, Inc. Implant delivery system
US6399655B1 (en) 1998-12-22 2002-06-04 Johns Hopkins University, School Of Medicine Method for the prophylactic treatment of cataracts
US6530950B1 (en) 1999-01-12 2003-03-11 Quanam Medical Corporation Intraluminal stent having coaxial polymer member
FR2788955B1 (en) * 1999-01-28 2001-04-06 Cie Mediterraneenne Des Cafes DEVICE FOR EXTRACTING COFFEE
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6298272B1 (en) 1999-03-29 2001-10-02 Cardiac Pacemakers, Inc. High impedance electrode tip with internal drug delivery capability
US6719805B1 (en) 1999-06-09 2004-04-13 C. R. Bard, Inc. Devices and methods for treating tissue
AU6517900A (en) 1999-08-03 2001-02-19 Smith & Nephew, Inc. Controlled release implantable devices
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6706023B1 (en) 1999-12-03 2004-03-16 Bionix Development Corporation Device for irrigation of a blind orifice
EP1104681A1 (en) 1999-12-03 2001-06-06 Biomat B.V. Wire, tube or catheter with hydrophilic coating
US6251136B1 (en) 1999-12-08 2001-06-26 Advanced Cardiovascular Systems, Inc. Method of layering a three-coated stent using pharmacological and polymeric agents
US6360129B1 (en) 1999-12-13 2002-03-19 Cardiac Pacemakers, Inc. Mannitol/hydrogel cap for tissue-insertable connections
JP2003520830A (en) 2000-01-25 2003-07-08 エドワーズ ライフサイエンシーズ コーポレイション Delivery system for treatment of restenosis and anastomotic intimal hyperplasia
AU781910B2 (en) * 2000-01-28 2005-06-23 Cook Medical Technologies Llc Endovascular medical device with plurality of wires
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
WO2001078626A1 (en) 2000-04-13 2001-10-25 Sts Biopolymers, Inc. Targeted therapeutic agent release devices and methods of making and using the same
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20020007214A1 (en) 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020007215A1 (en) 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020007213A1 (en) 2000-05-19 2002-01-17 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20020005206A1 (en) 2000-05-19 2002-01-17 Robert Falotico Antiproliferative drug and delivery device
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
US6506408B1 (en) * 2000-07-13 2003-01-14 Scimed Life Systems, Inc. Implantable or insertable therapeutic agent delivery device
US6743233B1 (en) * 2000-08-02 2004-06-01 Orthopaedic Biosystems, Ltd., Inc. Medical screw and method of installation
US6451373B1 (en) 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
US6613017B1 (en) 2000-08-08 2003-09-02 Scimed Life Systems, Inc. Controlled depth injection device and method
US6595958B1 (en) 2000-08-08 2003-07-22 Scimed Life Systems, Inc. Tortuous path injection device and method
DE60135352D1 (en) 2000-08-30 2008-09-25 Univ Johns Hopkins DEVICE FOR INTRA-OCCULAR ACTIVE AGGREGATION
US20020111590A1 (en) 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
DE60124285T3 (en) 2000-09-29 2011-03-17 Cordis Corp., Miami Lakes COATED MEDICAL EQUIPMENT
US20020051730A1 (en) 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
JP4583756B2 (en) 2000-10-31 2010-11-17 クック インコーポレイテッド Medical instruments
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US7077859B2 (en) 2000-12-22 2006-07-18 Avantec Vascular Corporation Apparatus and methods for variably controlled substance delivery from implanted prostheses
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US6824559B2 (en) 2000-12-22 2004-11-30 Advanced Cardiovascular Systems, Inc. Ethylene-carboxyl copolymers as drug delivery matrices
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US20040022853A1 (en) 2001-04-26 2004-02-05 Control Delivery Systems, Inc. Polymer-based, sustained release drug delivery system
US20020188170A1 (en) 2001-04-27 2002-12-12 Santamore William P. Prevention of myocardial infarction induced ventricular expansion and remodeling
US6673453B2 (en) 2001-06-12 2004-01-06 Biocoat Incorporated Coatings appropriate for medical devices
ATE506929T1 (en) 2001-06-12 2011-05-15 Univ Johns Hopkins Med RESERVOIR DEVICE FOR INTRAOCULAR MEDICINAL DELIVERY
US7485113B2 (en) 2001-06-22 2009-02-03 Johns Hopkins University Method for drug delivery through the vitreous humor
US20050129732A1 (en) 2001-07-13 2005-06-16 Flow Focusing, Inc. Biodegradable, antibiotic, controlled release tape
US20040142013A1 (en) 2001-07-13 2004-07-22 Flow Focusing, Inc. Implantable orthopedic surgical devices with controlled release antimicrobial component
US6497691B1 (en) 2001-08-24 2002-12-24 Polymer Group, Inc. Structurally durable, drapeable breathable barrier film compositions and articles
US8303651B1 (en) 2001-09-07 2012-11-06 Advanced Cardiovascular Systems, Inc. Polymeric coating for reducing the rate of release of a therapeutic substance from a stent
US20030158598A1 (en) 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
US6916321B2 (en) 2001-09-28 2005-07-12 Ethicon, Inc. Self-tapping resorbable two-piece bone screw
US20030097736A1 (en) * 2001-11-28 2003-05-29 Willis Blankenship Article securing strap assembly
US6764470B2 (en) 2001-12-03 2004-07-20 Roland P. Dimick Ear plug medication administration device
WO2003071986A2 (en) 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
US20030207856A1 (en) 2002-03-18 2003-11-06 Patrice Tremble Medical devices and compositions for delivering anti-proliferatives to anatomical sites at risk for restenosis
CN1655738A (en) 2002-05-20 2005-08-17 奥勃斯医学技术股份有限公司 Drug eluting implantable medical device
US7097850B2 (en) 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US20040138695A1 (en) 2002-06-18 2004-07-15 Shu-Tung Li Coatings of implants
US20030232087A1 (en) 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
US20030236513A1 (en) 2002-06-19 2003-12-25 Scimed Life Systems, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US7939094B2 (en) 2002-06-19 2011-05-10 Boston Scientific Scimed, Inc. Multiphase polymeric drug release region
US8211455B2 (en) 2002-06-19 2012-07-03 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US7169162B2 (en) 2002-07-03 2007-01-30 Orbusneich Medical, Inc. Balloon catheter
US20040006146A1 (en) 2002-07-06 2004-01-08 Evans Douglas G. Resorbable structure for treating and healing of tissue defects
DE60331552D1 (en) 2002-08-13 2010-04-15 Medtronic Inc PHARMACEUTICALS COMPOSITIONS USING POLY (ETHYLENE-CO (METH) ACRYLATE, MEDICAL DEVICE AND METHOD
US6731087B1 (en) * 2002-08-19 2004-05-04 Huang Chin-Cheng Fan motor
JP3642063B2 (en) * 2002-08-22 2005-04-27 株式会社村田製作所 Method for producing terbium-aluminum-based paramagnetic garnet single crystal
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
CA2498489C (en) 2002-09-29 2010-02-23 Surmodics, Inc. Method for subretinal administration of therapeutics including steroids;method for localizing pharmacodynamic action at the choroid and the retina; and related methods for treatment and/or prevention of retinal diseases
US7103418B2 (en) 2002-10-02 2006-09-05 Medtronic, Inc. Active fluid delivery catheter
US20040137059A1 (en) 2003-01-09 2004-07-15 Thierry Nivaggioli Biodegradable ocular implant
ATE476960T1 (en) 2003-05-02 2010-08-15 Surmodics Inc SYSTEM FOR THE CONTROLLED RELEASE OF A BIOACTIVE INGREDIENT IN THE BACK OF THE EYE
US7654997B2 (en) 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat

Also Published As

Publication number Publication date
JP2011167551A (en) 2011-09-01
DE602004028638D1 (en) 2010-09-23
US20050281863A1 (en) 2005-12-22
US20050271703A1 (en) 2005-12-08
ATE476960T1 (en) 2010-08-15
US20050276837A1 (en) 2005-12-15
US20060013835A1 (en) 2006-01-19
WO2004098565A2 (en) 2004-11-18
US7824704B2 (en) 2010-11-02
WO2004098565A3 (en) 2005-03-03
JP2006525091A (en) 2006-11-09
EP1633320A2 (en) 2006-03-15
JP2006312015A (en) 2006-11-16
US8021680B2 (en) 2011-09-20
US8034369B2 (en) 2011-10-11
AU2004237774A1 (en) 2004-11-18
CA2524271C (en) 2012-09-04
JP4824549B2 (en) 2011-11-30
US20050271706A1 (en) 2005-12-08
AU2004237774B2 (en) 2009-09-10
JP4897287B2 (en) 2012-03-14
US7976862B2 (en) 2011-07-12
JP5174213B2 (en) 2013-04-03
US20050287188A1 (en) 2005-12-29
US20050019371A1 (en) 2005-01-27

Similar Documents

Publication Publication Date Title
CA2524271A1 (en) Controlled release bioactive agent delivery device
ES2444792T3 (en) Implantable or insertable medical devices
AU2003261335B2 (en) Controlled drug delivery
EP1389472B1 (en) Endovascular implant having an active coating
CA2029046C (en) Sustained release compositions for treating periodontal disease
US7097850B2 (en) Bioactive agent release coating and controlled humidity method
AU2013338051C1 (en) Polymer coating compositions and coated products
CA2040914C (en) Treatment of erectile dysfunction
US20070255206A1 (en) Balloon for Use in Angioplasty
WO2002047731A3 (en) Drug delivery compositions and coated medical devices
AU2001249904A1 (en) Implant delivery catheter system and methods for its use
EP0387694B1 (en) Plaster as a therapeutic system for the stepwise release of medicaments to the skin, and process for its manufacture
WO2006020660A3 (en) Coated medical device having an increased coating surface area
WO1994008562A1 (en) Sustained release compositions for treating periodontal disease
EP1750782A1 (en) A balloon for use in angioplasty with an outer layer of nanofibers
WO2007021964A3 (en) Intravesical drug delivery device and method
CA2555288A1 (en) Novel lead retention means
JPH03502053A (en) Medical equipment for body cavity introduction
US20090099612A1 (en) Electrical conductor having a bioerodible coating
EP3634490B1 (en) Implantable drug delivery device
EP1690557A1 (en) Device for treatment of rectal disorders, and manufacturing process for the same
WO2004098451A3 (en) Coated medical devices and methods of making the same
US20110264055A1 (en) Medical Device
WO2021252897A3 (en) Therapeutic agent delivery systems and methods of forming and uses thereof

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20160429