CA2540447A1 - Apparatus and method for administering a therapeutic agent into tissue - Google Patents

Apparatus and method for administering a therapeutic agent into tissue Download PDF

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Publication number
CA2540447A1
CA2540447A1 CA002540447A CA2540447A CA2540447A1 CA 2540447 A1 CA2540447 A1 CA 2540447A1 CA 002540447 A CA002540447 A CA 002540447A CA 2540447 A CA2540447 A CA 2540447A CA 2540447 A1 CA2540447 A1 CA 2540447A1
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CA
Canada
Prior art keywords
ozone
generator
therapeutic agent
oxygen
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002540447A
Other languages
French (fr)
Other versions
CA2540447C (en
Inventor
Kieran P. Murphy
Mario Muto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ACTIVEO LLC
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2540447A1 publication Critical patent/CA2540447A1/en
Application granted granted Critical
Publication of CA2540447C publication Critical patent/CA2540447C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3478—Endoscopic needles, e.g. for infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3114—Filling or refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0216—Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1003—Spinal column
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/065—Guide needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod

Abstract

An apparatus (20) for administering a therapeutic agent is provided. The apparatus (20), in an embodiment, includes an ozone generator (24) connected to a scavenger (28) and an ozone administrator (32) via network of tubing (36,44,48) and valves (40,52,60). When activated and the valves (40,52,60) placed in the proper position, the ozone generator (24) will fill the ozone administrator (32) with ozone. The ozone generator (24) can then be turned off and the valves (40,52,60) moved so that the administrator (32) can be disconnected from the remainder of the apparatus (20). The administrator (32) is typically in the form of a syringe (56) and needle (64). Once the syringe (56) and needle (64) is filled with ozone, the needle (64) can be inserted into a tissue and the ozone expressed therefrom into the tissue. Various other apparatuses and methods are also contemplated.

Claims (22)

1. An apparatus for administering a therapeutic agent comprising:
a therapeutic agent generator; a scavenger connected to said generator via a first valve for capturing said therapeutic agent; and a therapeutic agent administrator connectable to said generator via at least one additional valve, such that when said valves are in a first position said generator communicates with said administrator for filling said administrator with said agent and when said valves are in a second position said administrator retains said agent therein upon disconnection from said generator and said scavenger captures any excess agent intermediate said administrator and said generator.
2. The apparatus of claim 1 wherein said agent is ozone.
3. The apparatus of claim 2 wherein said ozone is gas and said generator is a medical ozone generator.
4. The apparatus of claim 3 wherein said medical ozone is a ratio of oxygen (O2) and ozone (O3).
5. The apparatus of claim 3 wherein said ratio of oxygen to ozone is about 1 µg/ml
6. The apparatus of claim 3 wherein said ratio of oxygen to ozone is about µg/ml.
7. The apparatus of claim 3 wherein said ratio of oxygen to ozone is about 20µg/ml.
8. The apparatus of claim 3 wherein said ratio of oxygen to ozone is about 30 µg/ml.
9. The apparatus of claim 3 wherein said ratio of oxygen to ozone is about 40µg/ml.
10. The apparatus of claim 3 wherein said ratio of oxygen to ozone is about 50µg/ml.
11. The apparatus of claim 3 wherein said ratio of oxygen to ozone is between about 1 µg/ml and about 90µg/ml.
12. The apparatus of claim 3 wherein said ratio of oxygen to ozone is between about 10µg/m1 and about 80µg/ml.
13. The apparatus of claim 3 wherein said ratio of oxygen to ozone is between about 20µg/ml and about 70µg/ml.
14. The apparatus of claim 3 wherein said ratio of oxygen to ozone is between about 10µg/m1 and about 34µg/ml.
15. The apparatus of claim 3 wherein said ratio of oxygen to ozone is between about 27 µg/ml to about 28 µg/ml.
16. The apparatus of claim 3 wherein said administrator is a syringe.
17. A method of treating pain caused by a herniated disc comprising identifying the herniated disk and injecting medical ozone into the disc and paraspinous soft tissues.
18. A syringe for self-contained generation and administration of a therapeutic agent comprising:
a barrel for holding said agent;

a plunger for insertion into a first end of said barrel and expressing said .
agent from a second end of said barrel;
a power supply integrally mounted coaxially with said plunger;
a therapeutic agent generator integrally mounted coaxially with said plunger and in communication with said barrel through a channel in said plunger, said generator connected to said power supply and mounted coaxially with said plunger; a switch connected to said power supply such that when said switch is activated said therapeutic agent generator generates said therapeutic agent and fills said barrel therewith.
19. The syringe of claim 18 wherein said agent is ozone.
20. An implantable apparatus for self-contained generation and administration of a therapeutic agent comprising:
a chamber for holding said agent;
a catheter for connecting said chamber to an area for administration of said agent;
a power supply;
a therapeutic agent generator in communication with said chamber, said generator connected to said power supply;
a switch activatable externally by a patient implanted with said apparatus, said apparatus connected to said power supply such that when. said switch is activated said therapeutic agent generator generates said therapeutic agent and fills chamber therewith.
21. The syringe of claim 20 wherein said agent is ozone and said therapeutic agent generator is an ozone generator having a supply of oxygen intregally available therewith.
22. A kit of parts for use in administering a therapeutic agent comprising: a disinfectant; a drape; a skin preparation material; a local anesthetic; at least one syringe; at least one of a short and a long needle for use with said syringe;
a gantry drape for shielding a patient in an imaging device; a radiolucent needle holder; a nonionic x-ray dye; an infusion wire; a therapeutic agent generator and scavenger; a post-operative dressing for skin closure; adhesive bandages.
CA2540447A 2003-10-06 2004-10-01 Apparatus and method for administering a therapeutic agent into tissue Expired - Fee Related CA2540447C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US50830003P 2003-10-06 2003-10-06
US60/508,300 2003-10-06
US10/867,215 2004-06-15
US10/867,215 US7615030B2 (en) 2003-10-06 2004-06-15 Apparatus and method for administering a therapeutic agent into tissue
PCT/IB2004/003706 WO2005032387A2 (en) 2003-10-06 2004-10-01 Apparatus and method for administering a therapeutic agent

Publications (2)

Publication Number Publication Date
CA2540447A1 true CA2540447A1 (en) 2005-04-14
CA2540447C CA2540447C (en) 2010-07-20

Family

ID=34396446

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2540447A Expired - Fee Related CA2540447C (en) 2003-10-06 2004-10-01 Apparatus and method for administering a therapeutic agent into tissue

Country Status (7)

Country Link
US (5) US7615030B2 (en)
EP (1) EP1670526B1 (en)
JP (2) JP4734248B2 (en)
AU (4) AU2004277759B2 (en)
CA (1) CA2540447C (en)
DE (3) DE602004028532D1 (en)
WO (1) WO2005032387A2 (en)

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US20090209901A1 (en) 2009-08-20
AU2010206008A1 (en) 2010-08-26
US7615030B2 (en) 2009-11-10
US20050074501A1 (en) 2005-04-07
AU2010204469B2 (en) 2011-08-25
AU2004277759A1 (en) 2005-04-14
AU2010204467B2 (en) 2012-08-23
JP4734248B2 (en) 2011-07-27
DE602004028532D1 (en) 2010-09-16
CA2540447C (en) 2010-07-20
US8066695B2 (en) 2011-11-29
DE602004013027D1 (en) 2008-05-21
US20090254021A1 (en) 2009-10-08
WO2005032387A2 (en) 2005-04-14
US20090204062A1 (en) 2009-08-13
WO2005032387A3 (en) 2005-10-13
EP1670526A2 (en) 2006-06-21
US20090209902A1 (en) 2009-08-20
AU2010204467A1 (en) 2010-08-19
DE602004029210D1 (en) 2010-10-28
AU2004277759B2 (en) 2010-06-10
US8162873B2 (en) 2012-04-24
JP2011067648A (en) 2011-04-07
AU2010204469A1 (en) 2010-08-19
JP2007507272A (en) 2007-03-29
AU2010206008B2 (en) 2011-05-19
EP1670526B1 (en) 2008-04-09
DE602004013027T2 (en) 2009-05-14
JP5055417B2 (en) 2012-10-24

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