CA2569405A1 - Disposable bioreactor systems and methods - Google Patents

Disposable bioreactor systems and methods Download PDF

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Publication number
CA2569405A1
CA2569405A1 CA002569405A CA2569405A CA2569405A1 CA 2569405 A1 CA2569405 A1 CA 2569405A1 CA 002569405 A CA002569405 A CA 002569405A CA 2569405 A CA2569405 A CA 2569405A CA 2569405 A1 CA2569405 A1 CA 2569405A1
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CA
Canada
Prior art keywords
impeller
bioreactor
plastic bag
flexible plastic
bioreactor system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002569405A
Other languages
French (fr)
Other versions
CA2569405C (en
Inventor
Geoffrey Hodge
Parrish Galliher
Michael Fisher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
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Individual
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Application filed by Individual filed Critical Individual
Publication of CA2569405A1 publication Critical patent/CA2569405A1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B01F35/531—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
    • B01F35/5312—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom with vertical baffles mounted on the walls
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Packages (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)

Abstract

Accordingly, in one embodiment of the invention, a bioreactor system is presented and includes a disposable container for housing biomaterials for processing, the disposable container including at least one input port, at least one exhaust port, at least one harvest port, and the integrity of the sterile environment is protected with sterile filters attached to all external open ports a structure for supporting the disposable container, one or more sensors for sensing one or more parameters of the biomaterials in the container, a heater for heating the contents of the container, the heater having a thermostat and mixing system arranged with the system such that biomaterials contained in the disposable container are mixed.

Claims (29)

1. A bioreactor system comprising:

a disposable container for housing biomaterials for processing, the disposable container including at least one input port, at least one exhaust port;

at least one harvest port;

a structure for supporting the disposable container;

one or more sensors for sensing one or more parameters of the biomaterials in the container;

a heater for heating the contents of the container, the heater having a thermostat; and mixing system arranged with the system such that biomaterials contained in the disposable container are mixed.
2. The bioreactor according to claim 1, wherein the disposable container comprises a plastic container or a flexible plastic bag.
3. The bioreactor according to claim 1, wherein the disposable container includes one or more baffles.
4. The bioreactor according to claim 1, wherein the mixing system comprises a bubble column in conjunction with a divider positioned in the interior of the container.
5. The bioreactor according to claim 1, wherein the mixing means comprises an impeller positioned within the container at a lower portion of the container, driven by a motor external to the container.
6. The bioreactor according to claim 5, wherein the impeller is magnetically coupled to the motor.
7. The bioreactor according to claim 5, wherein the impeller is mechanically coupled to the motor.
8. The bioreactor according to claim 1, wherein the heater comprises an area of material positioned on the exterior of the vessel holding the disposable container.
9. The bioreactor according to claim 1, wherein the heater comprises a blanket of material or metal jacket containing heated or cooled water wrapped around at least a portion on the exterior of the vessel holding the disposable container.
10. The bioreactor according to claim 9, wherein the heater is positioned within or on the exterior of the disposable container.
11. The bioreactor according to claim 1, wherein the one or more sensors comprise sensors for detecting at least one of dissolved oxygen, dissolved carbon dioxide, mixing rate, gas flow rate, temperature, pH and pressure.
12. The bioreactor system according to claim 1, further comprising a computer for controlling the system.
13. The bioreactor system according to claim 1, further comprising at least one of an air supply, a carbon dioxide supply, and oxygen supply.
14. The bioreactor system according to claim 1, further comprising transporting means for moving the support structure.
15. The bioreactor system according to claim 14, wherein the transporting means comprises a dolly.
16. A bioreactor system comprising:
a support structure, a flexible plastic bag positioned within the support structure, the disposable container including:

an impeller plate affixed to a lower portion of the flexible plastic bag, the impeller plate including a post;

an impeller hub mounted on the post, the impeller hub having at least one impeller blade arranged on the post and having at least one magnet, a motor having shaft, the motor being provided adjacent to or within the support structure; and a motor hub mounted on the motor shaft, the motor hub including at least one magnet, wherein upon mounting of the flexible plastic bag within the support structure, the motor hub aligns with the impeller plate such that the magnet of the motor hub may align with the magnet of the impeller hub to drive the impeller hub when the motor shaft rotates.
17. The bioreactor system according to claim 16, wherein the motor hub further includes a lazy-susan bearing, wherein the bearing is positioned within the hub such that a portion of the bearing contacts one side of the impeller plate.
18. The bioreactor system according to claim 16, wherein the impeller plate further includes at least one porous element arranged to allow one or two-way fluid communication between an interior of the flexible plastic bag and an exterior of the flexible plastic bag.
19. The bioreactor system according to claim 18, wherein the fluid communication comprises introducing a gas sparge to the interior of the flexible plastic bag or removing fluids from the interior of the flexible plastic bag.
20. The bioreactor system according to claim 16, wherein the at least one impeller blade comprises a variable pitch impeller blade.
21. The bioreactor system according to claim 20, wherein the pitch of the impeller blade changes depending upon the rotational speed of the impeller hub.
22. The bioreactor system according to claim 20, wherein the pitch of the impeller blade is manually adjusted.
23. A bioreactor system comprising:
a support structure;

a flexible plastic bag positioned within the support structure, the disposable container including:

an impeller plate affixed to a lower portion of the flexible plastic bag;
a first shaft having a first end positioned within the interior of the flexible plastic bag and having a second end positioned on an exterior of the flexible plastic bag;

a seal surrounding the shaft;

an impeller hub mounted on the first end of the shaft, the impeller hub having at least one impeller blade arranged on the shaft;

a motor arranged adjacent to or within the support structure, upon mounting of the flexible plastic bag within the support structure, the second end of the shaft is driven by the motor.
24. The bioreactor system according to claim 23, wherein the impeller plate and/or seal includes a bearing.
25. The bioreactor system according to claim 23, wherein the impeller plate further includes at least one porous element arranged to allow one or two-way fluid communication between an interior of the flexible plastic bag and an exterior of the flexible plastic bag.
26. The bioreactor system according to claim 25, wherein the fluid communication comprises introducing a gas sparge to the interior of the flexible plastic bag or removing fluids from the interior of the flexible plastic bag.
27. The bioreactor system according to claim 23, wherein the at least one impeller blade comprises a variable pitch impeller blade.
28. The bioreactor system according to claim 27, wherein the pitch of the impeller blade changes depending upon the rotational speed of the impeller hub.
29. The bioreactor system according to claim 27, wherein the pitch of the impeller blade is manually adjusted.
CA2569405A 2004-06-04 2005-06-06 Disposable bioreactor systems and methods Active CA2569405C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US57714304P 2004-06-04 2004-06-04
US60/577,143 2004-06-04
US66925205P 2005-04-07 2005-04-07
US60/669,252 2005-04-07
PCT/US2005/020083 WO2005118771A2 (en) 2004-06-04 2005-06-06 Disposable bioreactor systems and methods

Publications (2)

Publication Number Publication Date
CA2569405A1 true CA2569405A1 (en) 2005-12-15
CA2569405C CA2569405C (en) 2011-05-03

Family

ID=35197799

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2569405A Active CA2569405C (en) 2004-06-04 2005-06-06 Disposable bioreactor systems and methods

Country Status (15)

Country Link
US (1) US7629167B2 (en)
EP (1) EP1773976B2 (en)
JP (1) JP4680990B2 (en)
KR (1) KR101021203B1 (en)
CN (2) CN101001945B (en)
AU (1) AU2005250500B2 (en)
BR (1) BRPI0510648B1 (en)
CA (1) CA2569405C (en)
CR (1) CR8769A (en)
DK (1) DK1773976T4 (en)
ES (1) ES2612212T5 (en)
HK (1) HK1112479A1 (en)
MX (1) MXPA06014099A (en)
NO (1) NO20070069L (en)
WO (1) WO2005118771A2 (en)

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