CA2606600A1 - Apparatus and methods for dispersing dry powder medicaments - Google Patents

Apparatus and methods for dispersing dry powder medicaments Download PDF

Info

Publication number
CA2606600A1
CA2606600A1 CA002606600A CA2606600A CA2606600A1 CA 2606600 A1 CA2606600 A1 CA 2606600A1 CA 002606600 A CA002606600 A CA 002606600A CA 2606600 A CA2606600 A CA 2606600A CA 2606600 A1 CA2606600 A1 CA 2606600A1
Authority
CA
Canada
Prior art keywords
feed tube
powder
receptacle
penetration
coupling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002606600A
Other languages
French (fr)
Other versions
CA2606600C (en
Inventor
Adrian E. Smith
John D. Burr
Jeffrey W. Etter
George S. Axford
Shirley W. Lyons
Robert M. Platz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/309,691 external-priority patent/US5785049A/en
Application filed by Individual filed Critical Individual
Publication of CA2606600A1 publication Critical patent/CA2606600A1/en
Application granted granted Critical
Publication of CA2606600C publication Critical patent/CA2606600C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0035Piercing means
    • A61M15/0036Piercing means hollow piercing means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • A61M15/0041Details of the piercing or cutting means with movable piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0053Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal
    • A61M15/0055Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type or way of disposal the used dosages being coiled
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0233Conductive materials, e.g. antistatic coatings for spark prevention
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/07General characteristics of the apparatus having air pumping means
    • A61M2205/071General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073Syringe, piston type

Abstract

A method for aerosolizing a powdered medicament comprises coupling a powder inlet end of a feed tube with a penetration in a receptacle containing the powder. Powder is drawn upward through the tube and dispersed in a high pressure gas stream flowing past a portion of the feed tube. Apparatus comprise the feed tube mounted within a base enclosure proximate a holder for one or more receptacles, which may be in the form of a cartridge containing a plurality of receptacles formed in a continuous web. The cartridge may be reciprocated relative to the feed tube and a separate piercing mechanism in order to sequentially piercing the receptacle and thereafter couple the feed tube through the resulting penetration for extracting the powder. Alternatively, penetration(s) through the receptacle may be formed as the feed tube is coupled, or some penetrations formed prior to coupling with other penetrations formed at the time of coupling.
CA002606600A 1994-09-21 1995-09-15 Apparatus and methods for dispersing dry powder medicaments Expired - Fee Related CA2606600C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/309,691 1994-09-21
US08/309,691 US5785049A (en) 1994-09-21 1994-09-21 Method and apparatus for dispersion of dry powder medicaments
US08/487,184 1995-06-07
US08/487,184 US5740794A (en) 1994-09-21 1995-06-07 Apparatus and methods for dispersing dry powder medicaments
CA002555600A CA2555600C (en) 1994-09-21 1995-09-15 Apparatus and methods for dispersing dry powder medicaments

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002555600A Division CA2555600C (en) 1994-09-21 1995-09-15 Apparatus and methods for dispersing dry powder medicaments

Publications (2)

Publication Number Publication Date
CA2606600A1 true CA2606600A1 (en) 1996-03-28
CA2606600C CA2606600C (en) 2009-09-01

Family

ID=26976958

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002606600A Expired - Fee Related CA2606600C (en) 1994-09-21 1995-09-15 Apparatus and methods for dispersing dry powder medicaments
CA002200727A Expired - Fee Related CA2200727C (en) 1994-09-21 1995-09-15 Apparatus and methods for dispersing dry powder medicaments
CA002555600A Expired - Fee Related CA2555600C (en) 1994-09-21 1995-09-15 Apparatus and methods for dispersing dry powder medicaments

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA002200727A Expired - Fee Related CA2200727C (en) 1994-09-21 1995-09-15 Apparatus and methods for dispersing dry powder medicaments
CA002555600A Expired - Fee Related CA2555600C (en) 1994-09-21 1995-09-15 Apparatus and methods for dispersing dry powder medicaments

Country Status (18)

Country Link
US (3) US6089228A (en)
EP (1) EP0846009B1 (en)
JP (1) JP3706136B2 (en)
CN (2) CN1131080C (en)
AT (1) ATE387925T1 (en)
AU (1) AU697676B2 (en)
BR (1) BR9508964A (en)
CA (3) CA2606600C (en)
CZ (1) CZ289029B6 (en)
ES (1) ES2302332T3 (en)
FI (1) FI971173A0 (en)
HU (1) HU220472B1 (en)
IL (3) IL126325A (en)
NO (3) NO971316L (en)
NZ (2) NZ293163A (en)
PL (2) PL188625B1 (en)
RU (1) RU2146153C1 (en)
WO (1) WO1996009085A1 (en)

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CA2200727A1 (en) 1996-03-28
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IL115369A0 (en) 1995-12-31
CZ289029B6 (en) 2001-10-17
US6543448B1 (en) 2003-04-08
HUT77691A (en) 1998-07-28
JP3706136B2 (en) 2005-10-12
RU2146153C1 (en) 2000-03-10
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WO1996009085A1 (en) 1996-03-28
CA2555600A1 (en) 1996-03-28
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PL319505A1 (en) 1997-08-18
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