CA2618408A1 - Polymethylmethacrylate revision bone cement - Google Patents

Polymethylmethacrylate revision bone cement Download PDF

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Publication number
CA2618408A1
CA2618408A1 CA002618408A CA2618408A CA2618408A1 CA 2618408 A1 CA2618408 A1 CA 2618408A1 CA 002618408 A CA002618408 A CA 002618408A CA 2618408 A CA2618408 A CA 2618408A CA 2618408 A1 CA2618408 A1 CA 2618408A1
Authority
CA
Canada
Prior art keywords
antibiotics
bone cement
pmma
cement according
granular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002618408A
Other languages
French (fr)
Other versions
CA2618408C (en
Inventor
Klaus-Dieter Kuehn
Sebastian Vogt
Hubert Buechner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kulzer GmbH
Original Assignee
Heraeus Kulzer GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heraeus Kulzer GmbH filed Critical Heraeus Kulzer GmbH
Publication of CA2618408A1 publication Critical patent/CA2618408A1/en
Application granted granted Critical
Publication of CA2618408C publication Critical patent/CA2618408C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

The invention relates to a PMMA revision bone cement having powder and liquid component, in which the powder component contains two or more granular antibiotics whose grain size distri-bution is equal in that the main screening fraction each of the individual antibiotics is in the same grain size range, in particular in the range of 100-250 µm or 150-250 µm.

Claims (9)

1. PMMA revision bone cement having powder and liquid component, characterized in that the powder component contains two or more granular antibiotics whose grain size distri-bution is equal in that the main screening fraction each of the individual antibiotics is in the same grain size range.
2. PMMA revision bone cement according to claim 1, whereby the main screening fraction of the antibiotics each comprises at least 50 weight percent of each antibiotic.
3. PMMA revision bone cement according to claim 1 or 2, whereby the grain size range of the main screening fraction of the individual antibiotics is 100 to 250 µm or 150 to 250 µm.
4. PMMA revision bone cement according to at least one of the preceding claims, in which the granular antibiotics consist of one or more members of the group of gentamicin sul-fate, gentamicin hydrochloride, amikacin sulfate, amikacin hydrochloride, tobramycin sul-fate, tobramycin hydrochloride, clindamycin hydrochloride, lincosamine hydrochloride, moxifloxacin, ciprofloxacin, teicoplanin, vancomycin, ramoplanin, dalbavancin, daptomy-cin, tigecyglin, metronidazole, tinidazole, and omidazole.
5. PMMA revision bone cement according to at least one of the preceding claims, whereby sparingly water-soluble salt forms of antibiotics from the group of antibiotics flavone phosphates, antibiotics palmitates, antibiotics myristates, and antibiotics laurates, are used as granular antibiotics.
6. PMMA revision bone cement according to at least one of the preceding claims, whereby antibiotics from the group of oxazolidones are used as granular antibiotics.
7. PMMA revision bone cement according to at least one of the preceding claims, whereby the granular antibiotics component, in addition, contains at least one excipient from the group of polyvinylpyrrolidone, polyethyleneglycol, polyethyleneoxide, maltose, sorbitol, and mannitol.
8. PMMA revision bone cement according to at least one of the preceding claims, whereby the granular antibiotics component, in addition, contains at least one excipient from the group of the toxicologically acceptable polymers, gelatin, collagen, and dextran.
9. PMMA revision bone cement according to at least one of the preceding claims, whereby at least a part of the granular antibiotics is glued or cemented by adhesive excipients into antibiotics granulates having particle sizes in the range of 63-900 µm.
CA2618408A 2007-01-26 2008-01-16 Polymethylmethacrylate revision bone cement Expired - Fee Related CA2618408C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007004968.6 2007-01-26
DE102007004968A DE102007004968B4 (en) 2007-01-26 2007-01-26 Revision polymethylmethacrylate bone cement

Publications (2)

Publication Number Publication Date
CA2618408A1 true CA2618408A1 (en) 2008-07-26
CA2618408C CA2618408C (en) 2012-02-28

Family

ID=39473999

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2618408A Expired - Fee Related CA2618408C (en) 2007-01-26 2008-01-16 Polymethylmethacrylate revision bone cement

Country Status (9)

Country Link
US (1) US8075907B2 (en)
EP (1) EP1949918B1 (en)
JP (1) JP4944809B2 (en)
CN (1) CN101229391B (en)
AU (1) AU2008200166B8 (en)
BR (1) BRPI0800183B8 (en)
CA (1) CA2618408C (en)
DE (1) DE102007004968B4 (en)
ZA (1) ZA200800717B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9931217B2 (en) 2013-07-08 2018-04-03 Heraeus Medical Gmbh Two-part articulating joint spacer and method for producing said joint spacer

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2942723B1 (en) * 2009-03-05 2011-06-10 Teknimes CEMENT FOR BONE FILLING
US9649404B2 (en) * 2009-03-05 2017-05-16 Teknimed Bone filling cement
PT2504353T (en) * 2009-11-23 2018-10-18 Cubist Pharmaceuticals Llc Lipopeptide compositions and related methods
US8673018B2 (en) 2010-02-05 2014-03-18 AMx Tek LLC Methods of using water-soluble inorganic compounds for implants
US8834772B2 (en) 2011-12-07 2014-09-16 Biomet Manufacturing, Llc Antimicrobial methacrylate cements
DE102014104676A1 (en) * 2014-04-02 2015-10-08 Heraeus Medical Gmbh Fosfomycin preparation, a process for preparing the preparation and a polymethyl methacrylate bone cement powder containing the preparation
DE102014218913A1 (en) * 2014-09-19 2016-03-24 Heraeus Medical Gmbh A process for producing an antibiotic polymethyl methacrylate bone cement powder and an antibiotic polymethyl methacrylate bone cement powder
CN105251038B (en) * 2015-10-09 2018-01-26 中国科学院长春应用化学研究所 A kind of anti-infective soft tissue medical adhesive and preparation method thereof
CN110975003A (en) * 2019-12-31 2020-04-10 苏州众泽医疗科技有限公司 Antibiotic bone cement for treating orthopedic infection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910259A (en) 1988-09-26 1990-03-20 Wolff & Kaaber A/S Bone cement
JPH05253286A (en) 1992-03-12 1993-10-05 Makoto Otsuka Bone-restoring material
SE9401169L (en) * 1994-04-08 1995-10-09 Corimed Gmbh Process for the preparation of an antibacterial active substance and its use
DE19641775A1 (en) * 1996-08-22 1998-02-26 Merck Patent Gmbh Process for the production of active ingredient-containing bone cements
US6355705B1 (en) 1997-02-07 2002-03-12 Queen's University At Kingston Anaesthetic bone cement
US5968253A (en) * 1998-07-31 1999-10-19 Norian Corporation Calcium phosphate cements comprising antimicrobial agents
DE19953975A1 (en) * 1999-11-10 2001-05-17 Gerd Hoermansdoerfer Bone cement
US6579533B1 (en) * 1999-11-30 2003-06-17 Bioasborbable Concepts, Ltd. Bioabsorbable drug delivery system for local treatment and prevention of infections
DE102004049121B4 (en) 2004-10-07 2008-01-10 Heraeus Kulzer Gmbh Antibiotic / antibiotics containing PMMA bone cement

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9931217B2 (en) 2013-07-08 2018-04-03 Heraeus Medical Gmbh Two-part articulating joint spacer and method for producing said joint spacer

Also Published As

Publication number Publication date
ZA200800717B (en) 2008-12-31
AU2008200166B8 (en) 2010-07-08
EP1949918B1 (en) 2012-08-08
US20080213336A1 (en) 2008-09-04
BRPI0800183B1 (en) 2018-05-08
DE102007004968A1 (en) 2008-07-31
CN101229391B (en) 2013-05-29
US8075907B2 (en) 2011-12-13
JP4944809B2 (en) 2012-06-06
AU2008200166A1 (en) 2008-08-14
DE102007004968B4 (en) 2011-03-10
JP2008183404A (en) 2008-08-14
CA2618408C (en) 2012-02-28
AU2008200166B2 (en) 2010-06-17
BRPI0800183B8 (en) 2021-06-22
CN101229391A (en) 2008-07-30
BRPI0800183A (en) 2008-09-16
EP1949918A2 (en) 2008-07-30
EP1949918A3 (en) 2011-10-05

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Effective date: 20210118