CA2626271A1 - Apparatus and method for performing counts within a biologic fluid sample - Google Patents
Apparatus and method for performing counts within a biologic fluid sample Download PDFInfo
- Publication number
- CA2626271A1 CA2626271A1 CA002626271A CA2626271A CA2626271A1 CA 2626271 A1 CA2626271 A1 CA 2626271A1 CA 002626271 A CA002626271 A CA 002626271A CA 2626271 A CA2626271 A CA 2626271A CA 2626271 A1 CA2626271 A1 CA 2626271A1
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- specific elements
- sample
- determining
- planar member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract 16
- 239000012530 fluid Substances 0.000 title claims abstract 10
- 238000011496 digital image analysis Methods 0.000 claims 4
- 210000000265 leukocyte Anatomy 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
Classifications
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- G01N15/1433—
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0822—Slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G01N2015/012—
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- G01N2015/016—
-
- G01N2015/018—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1486—Counting the particles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
Abstract
A method and an apparatus for enumerating one or more specific elements within a biologic fluid sample are provided. An embodiment of the method includes the steps of: a) providing a chamber formed between a first planar member that is transparent and a second planar member, which members are separated from one another by a substantially uniform height; b) introducing the biologic fluid sample into the chamber, wherein the chamber height is sized such that the sample extends between the first and second members, and sized relative to the specific elements within the sample such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber; c) examining substantially all of the sample within the chamber and enumerating all of at least one of the specific elements; d) determining the volume of sample contained within the chamber; and e) determining the number of the at least one of the specific elements per unit volume.
Claims (25)
1. A method for enumerating one or more specific elements within a biologic fluid sample, comprising the steps of:
providing a chamber formed between a first planar member that is transparent and a second planar member, which members are separated from one another by a substantially uniform height;
introducing the biologic fluid sample into the chamber, wherein the chamber height is sized such that the sample extends between the first and second members for at least a portion of the chamber, and wherein the chamber height is sized relative to the specific elements such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber;
examining substantially all of the sample within the chamber and enumerating all of at least one of the specific elements;
determining the volume of sample contained within the chamber; and determining the number of the at least one of the specific elements per unit volume.
providing a chamber formed between a first planar member that is transparent and a second planar member, which members are separated from one another by a substantially uniform height;
introducing the biologic fluid sample into the chamber, wherein the chamber height is sized such that the sample extends between the first and second members for at least a portion of the chamber, and wherein the chamber height is sized relative to the specific elements such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber;
examining substantially all of the sample within the chamber and enumerating all of at least one of the specific elements;
determining the volume of sample contained within the chamber; and determining the number of the at least one of the specific elements per unit volume.
2. The method of claim 1, wherein the biologic fluid sample is anticoagulated whole blood.
3. The method of claim 2, wherein the steps of examining, determining the volume, and determining the number utilize digital image analysis.
4. The method of claim 3, wherein the enumerated at least one of the specific elements includes white blood cells.
5. The method of claim 4, wherein the at least one of the specific elements are subsets of white blood cells having surface epitopes which are selectively stained to be identifiable and separately enumerated.
6. The method of claim 1, wherein the steps of examining, determining the volume, and determining the number utilize digital image analysis.
7. The method of claim 1, wherein all of specific elements non-uniformly distributed within the sample are enumerated.
8. A method for enumerating one or more specific elements within a biologic fluid sample, comprising the steps of:
providing a chamber formed between a first planar member that is transparent and a second planar member, which members are separated from one another by a substantially uniform height, which chamber has a known volume;
introducing the biologic fluid sample into the chamber, wherein the chamber height is sized such that the sample extends between the first and second members for substantially the entire extent of the chamber, and wherein the chamber height is sized relative to the specific elements such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber;
examining substantially all of the sample within the chamber and enumerating all of at least one of the specific elements; and determining the number of the at least one of the specific elements per unit volume.
providing a chamber formed between a first planar member that is transparent and a second planar member, which members are separated from one another by a substantially uniform height, which chamber has a known volume;
introducing the biologic fluid sample into the chamber, wherein the chamber height is sized such that the sample extends between the first and second members for substantially the entire extent of the chamber, and wherein the chamber height is sized relative to the specific elements such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber;
examining substantially all of the sample within the chamber and enumerating all of at least one of the specific elements; and determining the number of the at least one of the specific elements per unit volume.
9. The method of claim 8, wherein the biologic fluid sample is anticoagulated whole blood.
10. The method of claim 9, wherein the steps of examining, determining the volume, and determining the number utilize digital image analysis.
11. The method of claim 10, wherein the enumerated specific elements include white blood cells.
12 12. The method of claim 11, wherein the specific elements are subsets of white blood cells having surface epitopes which are selectively stained to be identifiable and separately enumerated.
13. The method of claim 8, wherein the steps of examining, determining the volume, and determining the number utilize digital image analysis.
14. An apparatus for enumerating one or more specific elements within a biologic fluid sample, comprising:
a first planar member that is transparent; and a second planar member;
wherein the members are separated from one another by a substantially uniform height, and the height is sized relative to the specific elements within the sample such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber.
a first planar member that is transparent; and a second planar member;
wherein the members are separated from one another by a substantially uniform height, and the height is sized relative to the specific elements within the sample such that the specific elements non-uniformly distribute within the sample upon introduction into the chamber.
15. The apparatus of claim 14, further comprising one or more sidewalls extending between the first planar member and the second planar member.
16. The apparatus of claim 15, further comprising an inlet port disposed in the first planar member.
17. The apparatus of claim 16, further comprising one or more vent apertures.
18. The apparatus of claim 15, wherein the one or more sidewalls include a bonding material.
19. The apparatus of claim 18, wherein the sidewalls are formed into a shape that substantially or completely encloses a chamber region.
20. The apparatus of claim 19, further comprising an inlet port disposed in the first planar member.
21. The apparatus of claim 20, further comprising one or more vent apertures.
22. The apparatus of claim 15, wherein the one or more sidewalls substantially consist of a bonding material.
23. The apparatus of claim 22, wherein the sidewalls are formed into a shape that substantially or completely encloses a chamber region.
24. The apparatus of claim 23, further comprising an inlet port disposed in the first planar member.
25. The apparatus of claim 24, further comprising one or more vent apertures.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72805805P | 2005-10-19 | 2005-10-19 | |
US60/728,058 | 2005-10-19 | ||
US11/257,757 | 2005-10-25 | ||
US11/257,757 US7731901B2 (en) | 2005-10-19 | 2005-10-25 | Apparatus and method for performing counts within a biologic fluid sample |
PCT/US2006/041011 WO2007047908A2 (en) | 2005-10-19 | 2006-10-17 | Apparatus and method for performing counts within a biologic fluid sample |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2626271A1 true CA2626271A1 (en) | 2007-04-26 |
CA2626271C CA2626271C (en) | 2011-07-12 |
Family
ID=37948604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2626271A Active CA2626271C (en) | 2005-10-19 | 2006-10-17 | Apparatus and method for performing counts within a biologic fluid sample |
Country Status (9)
Country | Link |
---|---|
US (4) | US7731901B2 (en) |
EP (1) | EP1949310B1 (en) |
JP (2) | JP4977711B2 (en) |
CN (1) | CN101322145B (en) |
AU (1) | AU2006304717B2 (en) |
CA (1) | CA2626271C (en) |
ES (1) | ES2716944T3 (en) |
HK (1) | HK1123873A1 (en) |
WO (1) | WO2007047908A2 (en) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2563002C (en) * | 2004-04-07 | 2011-07-12 | Wardlaw Partners Lp | Disposable chamber for analyzing biologic fluids |
US7731901B2 (en) | 2005-10-19 | 2010-06-08 | Abbott Laboratories | Apparatus and method for performing counts within a biologic fluid sample |
CA2718995C (en) * | 2008-03-21 | 2014-08-19 | Abbott Point Of Care, Inc. | Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
CA2719004C (en) | 2008-03-21 | 2013-06-18 | Abbott Point Of Care, Inc. | Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample |
US9638912B2 (en) * | 2008-03-21 | 2017-05-02 | Abbott Point Of Care, Inc. | Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample |
EP2271937B1 (en) | 2008-03-21 | 2016-01-13 | Abbott Point Of Care, Inc. | Method and apparatus for detecting and counting platelets individually and in aggregate clumps |
CN102016578B (en) | 2008-03-21 | 2014-10-01 | 艾博特健康公司 | Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
EP2269038B1 (en) | 2008-03-21 | 2016-07-27 | Abbott Point Of Care, Inc. | Method for analyzing individual cells or particulates in blood using fluorescence and absorption of a colorant |
ES2604978T3 (en) * | 2008-04-02 | 2017-03-10 | Abbott Point Of Care, Inc. | Virtual separation of bound and free marker in a ligand assay to perform immunoassays of biological fluids, including whole blood |
CA2720072C (en) * | 2008-04-09 | 2013-11-19 | Abbott Point Of Care, Inc. | Method of detecting very low levels of analyte within a thin film fluid sample contained in a thin thickness chamber |
WO2009126800A1 (en) * | 2008-04-09 | 2009-10-15 | Abbott Point Of Care, Inc. | Method for measuring the area of a sample disposed within an analysis chamber |
US9395365B2 (en) * | 2009-04-02 | 2016-07-19 | Abbott Point Of Care, Inc. | Detection of infectious disease in a human or animal by measuring specific phagocytosis in a thin film sample of their anticoagulated blood |
US20100255605A1 (en) * | 2009-04-02 | 2010-10-07 | Abbott Point Of Care, Inc. | Method and device for transferring biologic fluid samples |
US9075225B2 (en) | 2009-10-28 | 2015-07-07 | Alentic Microscience Inc. | Microscopy imaging |
EP2494400B1 (en) | 2009-10-28 | 2021-12-08 | Alentic Microscience Inc. | Microscopy imaging |
JP5709894B2 (en) * | 2009-12-18 | 2015-04-30 | アボット ポイント オブ ケア インコーポレイテッド | Biological fluid analysis cartridge |
EP2519820B1 (en) * | 2009-12-31 | 2013-11-06 | Abbott Point Of Care, Inc. | Method and apparatus for determining mean cell volume of red blood cells |
EP2526397B1 (en) * | 2010-01-20 | 2020-11-25 | Nexcelom Bioscience LLC | Cell counting and sample chamber and methods of fabrication |
KR20130054240A (en) * | 2010-03-04 | 2013-05-24 | 유니센서 에이/에스 | Flexible sample container |
US8472693B2 (en) | 2010-03-18 | 2013-06-25 | Abbott Point Of Care, Inc. | Method for determining at least one hemoglobin related parameter of a whole blood sample |
JP5663089B2 (en) * | 2010-08-05 | 2015-02-04 | アボット ポイント オブ ケア インコーポレイテッド | Method and apparatus for automated whole blood sample analysis from microscopic images |
WO2012092593A1 (en) | 2010-12-30 | 2012-07-05 | Abbott Point Of Care, Inc. | Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion |
CN103890590B (en) | 2011-08-24 | 2016-03-09 | 艾博特健康公司 | Biologicfluid sample analyzes box |
EP2929345A4 (en) | 2012-12-06 | 2015-11-18 | Abbott Point Of Care Inc | Imaging biologic fluids using a predetermined distribution |
US10502666B2 (en) | 2013-02-06 | 2019-12-10 | Alentic Microscience Inc. | Sample processing improvements for quantitative microscopy |
CA2953620C (en) | 2013-06-26 | 2020-08-25 | Alentic Microscience Inc. | Sample processing improvements for microscopy |
CA3036385C (en) * | 2013-12-17 | 2022-06-21 | Alentic Microscience Inc. | Dosimeters including lensless imaging systems |
WO2017027643A1 (en) | 2015-08-10 | 2017-02-16 | Essenlix Corp. | Bio/chemical assay devices and methods for simplified steps, small samples, accelerated speed, and ease-of-use |
CA2998635C (en) | 2015-09-14 | 2021-08-24 | Essenlix Corporation | Device and system for collecting and analyzing vapor condensate, particularly exhaled breath condensate, as well as method of using the same |
WO2017048871A1 (en) * | 2015-09-14 | 2017-03-23 | Essenlix Corp. | Device and system for analyzing a sample, particularly blood, as well as methods of using the same |
WO2017074815A1 (en) | 2015-10-26 | 2017-05-04 | Idexx Laboratories, Inc. | Hematology test slide |
CN105728069B (en) * | 2016-01-30 | 2021-01-19 | 深圳市安测健康信息技术有限公司 | Multi-channel micro-fluidic chip for rapidly self-checking blood |
JP6667052B1 (en) | 2016-12-21 | 2020-03-18 | エッセンリックス コーポレーション | Device and method for authenticating a sample and use thereof |
WO2018148342A1 (en) | 2017-02-07 | 2018-08-16 | Essenlix Corporation | Compressed open flow assay and use |
WO2018148469A1 (en) | 2017-02-08 | 2018-08-16 | Essenlix Corp. | Bio/chemical material extraction and assay |
CA3053132A1 (en) | 2017-02-09 | 2018-08-16 | Essenlix Corp. | Assay with amplification |
JP7004732B2 (en) | 2017-02-09 | 2022-01-21 | エッセンリックス コーポレーション | Assay method using different spacing heights |
JP2020507770A (en) | 2017-02-09 | 2020-03-12 | エッセンリックス コーポレーション | Colorimetric assay |
JP7107953B2 (en) | 2017-02-16 | 2022-07-27 | エッセンリックス コーポレーション | Assays using textured surfaces |
US20180333724A1 (en) * | 2017-05-22 | 2018-11-22 | Bioelectronica Corporation | Assay systems and methods for processing sample entities |
CN111492222A (en) | 2017-08-01 | 2020-08-04 | Essenlix公司 | Sample collection, retention and assay |
WO2019028133A1 (en) | 2017-08-01 | 2019-02-07 | Essenlix Corporation | Devices and methods for examining drug effects on microorganisms |
US11280706B2 (en) | 2017-08-01 | 2022-03-22 | Essenlix Corporation | Dilution calibration |
WO2019075415A1 (en) | 2017-10-13 | 2019-04-18 | Essenlix Corporation | Devices and methods for authenticating a medical test and use of the same |
US11609224B2 (en) | 2017-10-26 | 2023-03-21 | Essenlix Corporation | Devices and methods for white blood cell analyses |
US11237113B2 (en) | 2017-10-26 | 2022-02-01 | Essenlix Corporation | Rapid pH measurement |
US10807095B2 (en) | 2017-10-26 | 2020-10-20 | Essenlix Corporation | Making and tracking assay card |
WO2019118652A1 (en) | 2017-12-12 | 2019-06-20 | Essenlix Corporation | Sample manipulation and assay with rapid temperature change |
US10955334B2 (en) | 2017-12-14 | 2021-03-23 | Essenlix Corporation | Optical transmission sample holder and analysis, particularly for hemoglobin |
CN112534259A (en) | 2017-12-14 | 2021-03-19 | Essenlix公司 | Device, system and method for monitoring hair |
US11156606B2 (en) | 2018-01-11 | 2021-10-26 | Essenlix Corporation | Homogeneous assay (II) |
US11885952B2 (en) | 2018-07-30 | 2024-01-30 | Essenlix Corporation | Optics, device, and system for assaying and imaging |
USD898224S1 (en) | 2018-11-15 | 2020-10-06 | Essenlix Corporation | Assay plate with sample landing mark |
USD897555S1 (en) | 2018-11-15 | 2020-09-29 | Essenlix Corporation | Assay card |
USD898221S1 (en) | 2018-11-15 | 2020-10-06 | Essenlix Corporation | Assay plate |
USD898939S1 (en) | 2018-11-20 | 2020-10-13 | Essenlix Corporation | Assay plate with sample landing mark |
USD910202S1 (en) | 2018-11-21 | 2021-02-09 | Essenlix Corporation | Assay plate with sample landing mark |
USD893469S1 (en) | 2018-11-21 | 2020-08-18 | Essenlix Corporation | Phone holder |
USD910203S1 (en) | 2018-11-27 | 2021-02-09 | Essenlix Corporation | Assay plate with sample landing mark |
USD893470S1 (en) | 2018-11-28 | 2020-08-18 | Essenlix Corporation | Phone holder |
USD912842S1 (en) | 2018-11-29 | 2021-03-09 | Essenlix Corporation | Assay plate |
USD898222S1 (en) | 2019-01-18 | 2020-10-06 | Essenlix Corporation | Assay card |
USD1003453S1 (en) | 2019-05-14 | 2023-10-31 | Essenlix Corporation | Assay card hinge |
WO2021011944A2 (en) * | 2019-07-18 | 2021-01-21 | Essenlix Corporation | Imaging based homogeneous assay |
KR20230088443A (en) | 2020-10-19 | 2023-06-19 | 바이오 래드 래버러토리스 인코오포레이티드 | Systems and methods for rapid multiplexed sample processing with applications for nucleic acid amplification assays |
Family Cites Families (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1049364A (en) | 1962-07-20 | 1966-11-23 | Warner Lambert Pharmaceutical | An apparatus for and a method of automatically analyzing a plurality of samples |
US3447863A (en) * | 1966-07-11 | 1969-06-03 | Sodell Research & Dev Co | Method for preparing a slide for viewing |
US3607090A (en) | 1969-10-06 | 1971-09-21 | Scientific Industries | Analysis arrangment for multiple analyses of a single sample |
US3879106A (en) * | 1973-04-11 | 1975-04-22 | Pelam Inc | Microscope slide cover slip |
US4022521A (en) * | 1974-02-19 | 1977-05-10 | Honeywell Inc. | Microscope slide |
US4171866A (en) * | 1978-04-20 | 1979-10-23 | Tolles Walter E | Disposable volumetric slide |
US4218421A (en) * | 1978-08-18 | 1980-08-19 | Honeywell Inc. | Disposable container for a continuous band of test strips |
US4264560A (en) | 1979-12-26 | 1981-04-28 | Samuel Natelson | Clinical analytical system |
US4338024A (en) * | 1980-05-02 | 1982-07-06 | International Remote Imaging Systems, Inc. | Flow analyzer and system for analysis of fluids with particles |
JPS5790159A (en) * | 1980-11-27 | 1982-06-04 | Toa Medical Electronics Co Ltd | Blood analyzer |
US4447140A (en) * | 1982-09-29 | 1984-05-08 | Campbell Jeptha E | Microscope slides |
FR2565350B1 (en) * | 1984-06-05 | 1986-10-10 | Paris Nord Universite | PROPER MEANS FOR ALLOWING AUTOMATIC CONTINUOUS SUPPORT, PROCESSING, STORAGE AND ANALYSIS OF BIOLOGICAL SAMPLES |
US4689307A (en) | 1986-09-02 | 1987-08-25 | Caribbean Microparticles Corporation | Fluorescence microscopy sample mounting method and structure |
JPS6380216A (en) * | 1986-09-24 | 1988-04-11 | Bio Meito:Kk | Plastic slide glass |
US4950455A (en) * | 1987-12-22 | 1990-08-21 | Board Of Regents, University Of Texas System | Apparatus for quantifying components in liquid samples |
US5039487A (en) * | 1987-12-22 | 1991-08-13 | Board Of Regents, The University Of Texas System | Methods for quantifying components in liquid samples |
US5503803A (en) | 1988-03-28 | 1996-04-02 | Conception Technologies, Inc. | Miniaturized biological assembly |
US5472671A (en) | 1989-04-26 | 1995-12-05 | Nilsson; Sven-Erik | Cuvette |
US5184188A (en) | 1990-01-23 | 1993-02-02 | Medical Devices Corporation | Optical blood hemostatic analysis apparatus and method |
US6176962B1 (en) | 1990-02-28 | 2001-01-23 | Aclara Biosciences, Inc. | Methods for fabricating enclosed microchannel structures |
SE470347B (en) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Microstructure for fluid flow systems and process for manufacturing such a system |
US5321975A (en) * | 1991-10-04 | 1994-06-21 | Levine Robert A | Differential erythrocyte counts |
US5311975A (en) * | 1992-03-20 | 1994-05-17 | Hof Service Company, Inc. | Coin slide extension |
WO1994000761A1 (en) | 1992-06-26 | 1994-01-06 | Daikin Industries, Ltd. | Optical measurement instrument |
FR2694918B1 (en) | 1992-08-21 | 1994-12-23 | Millipore Sa | Packaging forming an envelope for an object, method and device for opening such an envelope and removing an object from it, and microbiological analysis method using such packaging. |
US5547849A (en) * | 1993-02-17 | 1996-08-20 | Biometric Imaging, Inc. | Apparatus and method for volumetric capillary cytometry |
US5585246A (en) | 1993-02-17 | 1996-12-17 | Biometric Imaging, Inc. | Method for preparing a sample in a scan capillary for immunofluorescent interrogation |
WO1995011621A1 (en) | 1993-10-28 | 1995-05-04 | I-Stat Corporation | Fluid sample collection and introduction device |
CA2156226C (en) | 1994-08-25 | 1999-02-23 | Takayuki Taguchi | Biological fluid analyzing device and method |
US5627041A (en) | 1994-09-02 | 1997-05-06 | Biometric Imaging, Inc. | Disposable cartridge for an assay of a biological sample |
US5504011A (en) | 1994-10-21 | 1996-04-02 | International Technidyne Corporation | Portable test apparatus and associated method of performing a blood coagulation test |
NL1000607C1 (en) * | 1995-02-07 | 1996-08-07 | Hendrik Jan Westendorp | Counting chamber and method for manufacturing a counting chamber |
NL9500281A (en) * | 1995-02-15 | 1996-09-02 | Jan Pieter Willem Vermeiden | Counting chamber for biological research as well as a method for the production of such a counting chamber. |
SE504193C2 (en) | 1995-04-21 | 1996-12-02 | Hemocue Ab | Capillary microcuvette |
JP3329988B2 (en) * | 1995-06-09 | 2002-09-30 | 株式会社クラレ | Plastic slide for optical microscope |
US5641458A (en) | 1995-06-15 | 1997-06-24 | Shockley, Jr.; H. David | Flow through cell assembly |
US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
US5726751A (en) * | 1995-09-27 | 1998-03-10 | University Of Washington | Silicon microchannel optical flow cytometer |
US5837547A (en) * | 1995-12-27 | 1998-11-17 | Caribbean Microparticles Corporation | Flow cytometer calibration method |
US5985218A (en) | 1996-07-03 | 1999-11-16 | Beckman Coulter, Inc. | Reagent cartridge |
EP0929658A4 (en) * | 1996-08-26 | 2005-11-02 | Univ Princeton | Reversibly sealable microstructure sorting devices |
US5968453A (en) | 1997-07-17 | 1999-10-19 | Carolina Liquid Chemistries Corporation | Reagent cartridge |
US5812312A (en) * | 1997-09-04 | 1998-09-22 | Lorincz; Andrew Endre | Microscope slide |
US6016712A (en) | 1997-09-18 | 2000-01-25 | Accumetrics | Device for receiving and processing a sample |
US6573988B1 (en) | 1997-10-31 | 2003-06-03 | Foss Electric A/S | Cuvette and spacer therefor as well as a method of producing the spacer |
WO1999024831A1 (en) * | 1997-11-11 | 1999-05-20 | Kowa Company, Ltd. | Method of counting leukocytes and leukocyte counter |
SE9800070D0 (en) | 1998-01-14 | 1998-01-14 | Hemocue Ab | mixing method |
US6723290B1 (en) * | 1998-03-07 | 2004-04-20 | Levine Robert A | Container for holding biologic fluid for analysis |
US6350613B1 (en) * | 1998-03-07 | 2002-02-26 | Belton Dickinson & Co. | Determination of white blood cell differential and reticulocyte counts |
US6929953B1 (en) * | 1998-03-07 | 2005-08-16 | Robert A. Levine | Apparatus for analyzing biologic fluids |
US5948686A (en) | 1998-03-07 | 1999-09-07 | Robert A. Leuine | Method for performing blood cell counts |
US6004821A (en) * | 1998-03-07 | 1999-12-21 | Levine; Robert A. | Method and apparatus for performing chemical, qualitative, quantitative, and semi-quantitative analyses of a urine sample |
US6235536B1 (en) * | 1998-03-07 | 2001-05-22 | Robert A. Levine | Analysis of quiescent anticoagulated whole blood samples |
JP4499918B2 (en) | 1998-03-27 | 2010-07-14 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Miniaturized microtiter plate for high-throughput screening |
ATE246352T1 (en) | 1998-05-13 | 2003-08-15 | Bayer Ag | FLOW Cuvette FOR SPECTROSCOPIC EXAMINATION OF A SAMPLE |
EP1046032A4 (en) | 1998-05-18 | 2002-05-29 | Univ Washington | Liquid analysis cartridge |
US6180314B1 (en) * | 1998-05-27 | 2001-01-30 | Becton, Dickinson And Company | Method for preparing thin liquid samples for microscopic analysis |
US6261519B1 (en) | 1998-07-20 | 2001-07-17 | Lifescan, Inc. | Medical diagnostic device with enough-sample indicator |
US6521182B1 (en) | 1998-07-20 | 2003-02-18 | Lifescan, Inc. | Fluidic device for medical diagnostics |
DE19847617C2 (en) * | 1998-10-15 | 2002-11-07 | Sensor Instr Gmbh | Method and device for measuring the length of the light guide |
US6197593B1 (en) * | 1998-10-20 | 2001-03-06 | Coulter International Corp. | Method for enumerating blood cells |
AU3609900A (en) | 1999-03-02 | 2000-09-21 | Qualigen, Inc. | Methods and apparatus for separation of biological fluids |
US6150178A (en) | 1999-03-24 | 2000-11-21 | Avitar, Inc. | Diagnostic testing device |
US6391541B1 (en) | 1999-05-28 | 2002-05-21 | Kurt E. Petersen | Apparatus for analyzing a fluid sample |
US6448090B1 (en) | 1999-07-09 | 2002-09-10 | Orchid Biosciences, Inc. | Fluid delivery system for a microfluidic device using alternating pressure waveforms |
US6395232B1 (en) | 1999-07-09 | 2002-05-28 | Orchid Biosciences, Inc. | Fluid delivery system for a microfluidic device using a pressure pulse |
US6365111B1 (en) | 1999-08-25 | 2002-04-02 | Randall C. Bass | Holder for specimen examination |
DE19941905C2 (en) | 1999-09-02 | 2002-06-06 | Max Planck Gesellschaft | Sample chamber for the liquid treatment of biological samples |
WO2001021163A2 (en) * | 1999-09-21 | 2001-03-29 | Emory University | Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents |
EP1224258A2 (en) | 1999-10-29 | 2002-07-24 | Pall Corporation | Biological fluid processing |
US6420114B1 (en) | 1999-12-06 | 2002-07-16 | Incyte Genomics, Inc. | Microarray hybridization chamber |
JP2001174456A (en) * | 1999-12-20 | 2001-06-29 | Toyobo Co Ltd | Device and method for subclassification of leukocyte |
US7641856B2 (en) | 2004-05-14 | 2010-01-05 | Honeywell International Inc. | Portable sample analyzer with removable cartridge |
US8071051B2 (en) | 2004-05-14 | 2011-12-06 | Honeywell International Inc. | Portable sample analyzer cartridge |
US6597438B1 (en) | 2000-08-02 | 2003-07-22 | Honeywell International Inc. | Portable flow cytometry |
US20060263888A1 (en) | 2000-06-02 | 2006-11-23 | Honeywell International Inc. | Differential white blood count on a disposable card |
US7978329B2 (en) | 2000-08-02 | 2011-07-12 | Honeywell International Inc. | Portable scattering and fluorescence cytometer |
DE10033268C2 (en) | 2000-07-10 | 2002-08-08 | Innovatis Gmbh | Method for examining cells in a culture fluid |
US7000330B2 (en) | 2002-08-21 | 2006-02-21 | Honeywell International Inc. | Method and apparatus for receiving a removable media member |
US7277166B2 (en) | 2000-08-02 | 2007-10-02 | Honeywell International Inc. | Cytometer analysis cartridge optical configuration |
JP2002214241A (en) | 2000-11-20 | 2002-07-31 | Minolta Co Ltd | Microchip |
US6613286B2 (en) | 2000-12-21 | 2003-09-02 | Walter J. Braun, Sr. | Apparatus for testing liquid/reagent mixtures |
WO2002059579A1 (en) * | 2001-01-25 | 2002-08-01 | Texas Tech University | Universal detector for biological and chemical separations or assays using plastic microfluidic devices |
US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US6902534B2 (en) | 2001-03-30 | 2005-06-07 | Becton, Dickinson And Company | Method and kit of components for delivering blood to a portable clinical analyzer |
EP1416851B1 (en) * | 2001-06-08 | 2006-08-09 | Roche Diagnostics GmbH | Bodily fluid sampling device and test media cassette to be used with such a device |
US7179423B2 (en) * | 2001-06-20 | 2007-02-20 | Cytonome, Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
KR100425536B1 (en) | 2001-07-16 | 2004-03-30 | 학교법인 포항공과대학교 | Bread board for microfluidic chip |
SE0201738D0 (en) | 2002-06-07 | 2002-06-07 | Aamic Ab | Micro-fluid structures |
US7351379B2 (en) * | 2002-06-14 | 2008-04-01 | Agilent Technologies, Inc. | Fluid containment structure |
US7220593B2 (en) | 2002-10-03 | 2007-05-22 | Battelle Memorial Institute | Buffy coat separator float system and method |
TW587694U (en) | 2003-03-14 | 2004-05-11 | Mau-Guei Jang | Protruded platform type quantitative cell counter plate |
JP5118849B2 (en) | 2003-03-17 | 2013-01-16 | チャールズ リバー ラボラトリーズ, インコーポレイテッド | Methods and compositions for detection of microbial contaminants |
US7364699B2 (en) | 2003-06-18 | 2008-04-29 | Bayer Healthcare Llc | Containers for reading and handling diagnostic reagents and methods of using the same |
US7723099B2 (en) | 2003-09-10 | 2010-05-25 | Abbott Point Of Care Inc. | Immunoassay device with immuno-reference electrode |
US7671974B2 (en) | 2003-10-29 | 2010-03-02 | Chf Solutions Inc. | Cuvette apparatus and system for measuring optical properties of a liquid such as blood |
US7468160B2 (en) | 2003-12-05 | 2008-12-23 | Agilent Technologies, Inc. | Devices and methods for performing array based assays |
KR100572207B1 (en) | 2003-12-18 | 2006-04-19 | 주식회사 디지탈바이오테크놀러지 | Bonding method of plastic microchip |
CA2563002C (en) * | 2004-04-07 | 2011-07-12 | Wardlaw Partners Lp | Disposable chamber for analyzing biologic fluids |
US8916348B2 (en) | 2004-05-06 | 2014-12-23 | Clondiag Gmbh | Method and device for the detection of molecular interactions |
WO2005111580A1 (en) | 2004-05-07 | 2005-11-24 | Optiscan Biomedical Corporation | Sample element with fringing-reduction capabilities |
US8097225B2 (en) | 2004-07-28 | 2012-01-17 | Honeywell International Inc. | Microfluidic cartridge with reservoirs for increased shelf life of installed reagents |
US7381374B2 (en) | 2004-09-22 | 2008-06-03 | Hsiao-Chung Tsai | Immunoassay devices and methods of using same |
CN1287151C (en) * | 2005-01-04 | 2006-11-29 | 济南市中心医院 | Dedicated Hemolysin for flow cytometer and preparing method and application thereof |
SE528697C2 (en) | 2005-03-11 | 2007-01-30 | Hemocue Ab | Volumetric determination of the number of white blood cells in a blood sample |
SE528638C2 (en) | 2005-04-08 | 2007-01-09 | Boule Medical Ab | Device for filling a unit for determining a sample volume |
US7803319B2 (en) | 2005-04-29 | 2010-09-28 | Kimberly-Clark Worldwide, Inc. | Metering technique for lateral flow assay devices |
JP2007033350A (en) | 2005-07-29 | 2007-02-08 | Hitachi High-Technologies Corp | Chemical analyzing apparatus |
US7731901B2 (en) | 2005-10-19 | 2010-06-08 | Abbott Laboratories | Apparatus and method for performing counts within a biologic fluid sample |
US8936945B2 (en) | 2005-11-17 | 2015-01-20 | The Regents Of The University Of Michigan | Compositions and methods for liquid metering in microchannels |
EP1963817A2 (en) | 2005-12-22 | 2008-09-03 | Honeywell International Inc. | Portable sample analyzer cartridge |
US7976795B2 (en) | 2006-01-19 | 2011-07-12 | Rheonix, Inc. | Microfluidic systems |
SE531233C2 (en) | 2006-03-28 | 2009-01-27 | Hemocue Ab | Apparatus and method for detecting fluorescently labeled biological components |
US20080176253A1 (en) | 2006-05-10 | 2008-07-24 | The Board Of Regents Of The University Of Texas System | Detecting human or animal immunoglobin-e |
EP1878497A1 (en) | 2006-07-14 | 2008-01-16 | Roche Diagnostics GmbH | Disposable for analyzing a liquid sample by nucleic acid amplification |
FR2908999B1 (en) | 2006-11-29 | 2012-04-27 | Biomerieux Sa | NOVEL DRUG FOR THE INHIBITION, PREVENTION OR TREATMENT OF RHEUMATOID ARTHRITIS. |
US7802467B2 (en) | 2006-12-22 | 2010-09-28 | Abbott Diabetes Care Inc. | Analyte sensors and methods of use |
GB2445738A (en) | 2007-01-16 | 2008-07-23 | Lab901 Ltd | Microfluidic device |
JP4894526B2 (en) | 2007-01-17 | 2012-03-14 | 横河電機株式会社 | Chemical reaction cartridge |
US7738094B2 (en) | 2007-01-26 | 2010-06-15 | Becton, Dickinson And Company | Method, system, and compositions for cell counting and analysis |
WO2008101196A1 (en) | 2007-02-15 | 2008-08-21 | Osmetech Molecular Diagnostics | Fluidics devices |
BRPI0812391A2 (en) | 2007-06-20 | 2015-11-24 | Mec Dynamics Corp | cartridge and method of determining blood clotting time |
TW200920841A (en) * | 2007-09-25 | 2009-05-16 | Cytyc Corp | Microfluidic apparatus for manipulating imaging and analyzing cells of a cytological specimen |
EP2050498A1 (en) | 2007-10-19 | 2009-04-22 | Koninklijke Philips Electronics N.V. | Fluid handling device for analysis of fluid samples |
CA2705355C (en) | 2007-11-13 | 2013-02-26 | F. Hoffmann-La Roche Ag | Modular sensor cassette |
EP2081018A1 (en) | 2008-01-18 | 2009-07-22 | F.Hoffmann-La Roche Ag | Gas sensor with microporous electrolyte layer |
US20120004140A1 (en) | 2008-02-01 | 2012-01-05 | Complete Genomics, Inc. | Flow cells for biochemical analysis |
EP2271937B1 (en) | 2008-03-21 | 2016-01-13 | Abbott Point Of Care, Inc. | Method and apparatus for detecting and counting platelets individually and in aggregate clumps |
EP2269038B1 (en) | 2008-03-21 | 2016-07-27 | Abbott Point Of Care, Inc. | Method for analyzing individual cells or particulates in blood using fluorescence and absorption of a colorant |
CN102016578B (en) | 2008-03-21 | 2014-10-01 | 艾博特健康公司 | Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
CA2718995C (en) | 2008-03-21 | 2014-08-19 | Abbott Point Of Care, Inc. | Method and apparatus for determining red blood cell indices of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells |
ES2604978T3 (en) | 2008-04-02 | 2017-03-10 | Abbott Point Of Care, Inc. | Virtual separation of bound and free marker in a ligand assay to perform immunoassays of biological fluids, including whole blood |
CA2720072C (en) | 2008-04-09 | 2013-11-19 | Abbott Point Of Care, Inc. | Method of detecting very low levels of analyte within a thin film fluid sample contained in a thin thickness chamber |
US20100189338A1 (en) | 2008-04-09 | 2010-07-29 | Nexcelom Bioscience | Systems and methods for counting cells and biomolecules |
WO2009126800A1 (en) | 2008-04-09 | 2009-10-15 | Abbott Point Of Care, Inc. | Method for measuring the area of a sample disposed within an analysis chamber |
KR100960066B1 (en) | 2008-05-14 | 2010-05-31 | 삼성전자주식회사 | Microfluidic device containing lyophilized reagent therein and analysing method using the same |
US7976789B2 (en) | 2008-07-22 | 2011-07-12 | The Board Of Trustees Of The University Of Illinois | Microfluidic device for preparing mixtures |
DE102009015395B4 (en) | 2009-03-23 | 2022-11-24 | Thinxxs Microtechnology Gmbh | Flow cell for treating and/or examining a fluid |
JP5709894B2 (en) | 2009-12-18 | 2015-04-30 | アボット ポイント オブ ケア インコーポレイテッド | Biological fluid analysis cartridge |
EP2519820B1 (en) | 2009-12-31 | 2013-11-06 | Abbott Point Of Care, Inc. | Method and apparatus for determining mean cell volume of red blood cells |
US8472693B2 (en) | 2010-03-18 | 2013-06-25 | Abbott Point Of Care, Inc. | Method for determining at least one hemoglobin related parameter of a whole blood sample |
EP2591358B1 (en) | 2010-07-05 | 2016-09-07 | Koninklijke Philips N.V. | Examination system with sample incubation |
JP5663089B2 (en) | 2010-08-05 | 2015-02-04 | アボット ポイント オブ ケア インコーポレイテッド | Method and apparatus for automated whole blood sample analysis from microscopic images |
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2005
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- 2006-10-17 EP EP06817200.6A patent/EP1949310B1/en active Active
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- 2006-10-17 WO PCT/US2006/041011 patent/WO2007047908A2/en active Application Filing
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CN101322145B (en) | 2011-11-23 |
CA2626271C (en) | 2011-07-12 |
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US20070087442A1 (en) | 2007-04-19 |
JP4977711B2 (en) | 2012-07-18 |
EP1949310A2 (en) | 2008-07-30 |
WO2007047908A2 (en) | 2007-04-26 |
AU2006304717A8 (en) | 2008-07-03 |
US8158434B2 (en) | 2012-04-17 |
JP2012098302A (en) | 2012-05-24 |
JP2009512859A (en) | 2009-03-26 |
AU2006304717A1 (en) | 2007-04-26 |
ES2716944T3 (en) | 2019-06-18 |
AU2006304717B2 (en) | 2010-05-27 |
WO2007047908A3 (en) | 2007-06-14 |
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