CA2638740C - Radiation detection apparatus - Google Patents

Radiation detection apparatus Download PDF

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Publication number
CA2638740C
CA2638740C CA2638740A CA2638740A CA2638740C CA 2638740 C CA2638740 C CA 2638740C CA 2638740 A CA2638740 A CA 2638740A CA 2638740 A CA2638740 A CA 2638740A CA 2638740 C CA2638740 C CA 2638740C
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CA
Canada
Prior art keywords
probe
cover
handle
switch assembly
radiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2638740A
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French (fr)
Other versions
CA2638740A1 (en
Inventor
Eric Miller
Richard Scott Rader
Timothy N. Wells
Paul Stoppel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Surgical Corp
Radiation Monitoring Devices Inc
Original Assignee
United States Surgical Corp
Radiation Monitoring Devices Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by United States Surgical Corp, Radiation Monitoring Devices Inc filed Critical United States Surgical Corp
Publication of CA2638740A1 publication Critical patent/CA2638740A1/en
Application granted granted Critical
Publication of CA2638740C publication Critical patent/CA2638740C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01TMEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/16Measuring radiation intensity
    • G01T1/161Applications in the field of nuclear medicine, e.g. in vivo counting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/42Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4258Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector for detecting non x-ray radiation, e.g. gamma radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/54Control of apparatus or devices for radiation diagnosis
    • A61B6/548Remote control of the apparatus or devices

Abstract

A hand-held radiation detection probe is disclosed for use in detecting radiation emitted from a radiation emitting substance in a patient's body, said probe having a removable protective cover thereover to protect said probe from contamination during storage or use. The probe further includes a handle and a switch assembly. The cover covers the handle and the switch assembly is removably mounted onto the handle over the cover.

Description

RADIATION DETECTION APPARATUS
BACKGROUND OF THE INVENTION
This application is a division of Canadian Application Serial No. 2,347,622 filed October 21, 1999.
1. Field of the Invention The present invention relates to a radiation detection apparatus. More particularly, the present invention relates to an apparatus for detecting, quantizing and mapping radiation einitted trom a scintillation fluid having gamma-emitting isotopes. The apparatus is battery operated and lias a hand-held probe for detecting radiation, and for transinitting electrical signals that represent the detected radiation to a remote unit to process the signals into information. The hand-held probe is a scintillation detector that has a switch assembly removably mounted on the probe for initiating remotely electrical signals to a control unit.
The switch assembly has preferably two finger-operated triggers. One trigger initiates the count, and the other trigger directs the remote unit to download, and preferably record, the counted scintillations or averaged scintillation values for fiirther use.
2. Descriptions of the Prior Art Procedures for detecting, quantizing and localizing or mapping carcinomas in living beings ai-e known. A radiation-emitting substance is passed through a patient's body. Either a radiation detector device is secured to the patient's body, or a hand-lield probe is held adjacent a series of sites surrounding a suspected tumor.
One procedure involves injecting a scintillation fluid containing, for example, technetiuin 99, in quadrants of the capillary system located about a site to determine whether cancer has spread to the lymphatic system. Since fluid drains from the injected area through the lymphatic system, the scintillation detector allows identification and location ofthe sentinel node, the first lymph node draining the most scintillation fluid and emitting the highest number of scintillations in the lymphatic drainage path fi-om the tLunor.
Heretofore, each radiation detecting, quantizing and mapping apparatus has been connected by hardwire to an electrical receptacle or I

has a battery that discharges during use. One conventional apparatus has a foot pedal connected to a remote unit to initiate counts. The foot pedal does not activate a downloading of counts, let alone during a preset time period. A second conventional apparatus has a built-in rechargeable battery. This is disadvantageous since an extended time, usually four to six hours, is required to recharge the battery. Since recharging cannot occur during operation of the apparatus, should the battery require recharging during a procedure, the procedure must be stopped.
In addition, the apparatus has a hand-held probe and a remotely io located control unit. The probe was merely used for detecting emitted radiation from the patient's body and transmitting electric signals representing the detected radiation to the control unit for processing. The control unit has the controls for controlling various functions including taking counts, setting the time period for taking timed counts, and initiating 1s the taking of counts. These controls had to be activated solely at the control unit. This is disadvantageous because to conduct the counting procedure, the operator must hold and use the hand-held radiation detection probe with one hand. With the other hand, the operator needed to reach the control unit and manipulate the controls. It is difficult to 20 conduct both the detection and control manipulation simultaneously. Also, to do so results in difficulties in taking counts and, perhaps, inaccuracies in the counts. For example, while taking a scintillation count, the probe must be precisely positioned over a selected site for a set period of time. It is difficult to maintain that precise position while reaching to depress a count 25 start button on the control unit. Movement of the probe during counting can create an inaccurate count. Since counting is repeated at different probe angle positions over the same site and over different body sites, the difficulties and inaccuracies can be compounded. Therefore, it is desired to have an improved radiation detection apparatus that obviates or reduces =
30 such difficulties, inaccuracies and inefficiencies.
It is known to employ switches removably mounted on a handpiece.
U.S. Patent No. 5,304,763 discloses two or more finger-operated switches removably mounted to a hand-held electrosurgical device. The switches control the application, e.g., initiation and termination, of electrical energy provided to the device. For example, one switch controls the application of energy to energize an electrode of the device for cutting body tissue. The other switch energizes a suction portion of the device to remove cut tissue from the body.
Heretofore, hand-held radiation detection probes and their cables have had to be sterilized to be re-usable because they become contaminated during use.
Sterilizing such hand-held detection devices prior to each use is expensive, time consuming and may require maintaining a larger than necessary inventory of the probes and cables. It is desired to have an apparatus that obviates the need for sterilizing hand-held devices or probes prior to their re-use. It would also be desired to have an apparatus that allows for the use of hand-operated switches mounted on the hand-held device or probe during use, but permits removal from it during sterilization of the device or probe.
SUMMARY OF THE INVENTION
In accordance with an embodiment of the present invention there is provided a hand-held radiation detection probe for use in detecting radiation emitted from a radiation emitting substance in a patient's body, the probe having a removable protective cover thereover to protect the probe from contamination during storage or use.

Preferably, the cover permits the probe to be re-used without prior sterilization. The cover may be a flexible sheath or a drape.
In a preferred embodiment the probe is elongated and has a detector at one end and a handle at the other end. Preferably, the cover is a flexible sheath closed at one end about said detector and open at its opposed end beyond the handle.

In a preferred embodiment a switch assembly is removably mounted onto the handle over the cover.
3 Preferably, activation of the second means is operative, only during the preset time period, to cause the output means to manifest a scintillation count accumulated during the second period from the counter means.
Activation of the second means, at times other than during the preset time period, causes activation of any selected other function of the control unit.
The radiation detection apparatus can include a movable stand having a holder for releasably mounting the probe on the stand.
The present invention also includes a hand-held radiation detection probe having a flexible removable protective covering thereover to protect io the probe from contamination during storage or use, and permit the probe to be re-used without prior sterilization. Preferably, the covering is a sheath.
The present invention may further include a hand-held radiation detection probe having a switch assembly removably mounted thereon.
The switch assembly has at least one switch, an insulating member for electrically insulating said switch from said probe which is a saddle formed by a spaced, opposed pair of cooperative depending gripping members adapted to releasably grip said probe therebetween.

2o BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is a schematic representation of the radiation detection apparatus of the present invention;
Fig. 2 is a top plan view, with portions broken away, of a preferred embodiment of the probe shown in Fig. 1;
Fig. 3 is a top plan view, with portions broken away, of the probe shown in Fig. 2 without a switch mounted thereon and covered by a sheath;
Fig. 4 is a top plan view, with portions broken away, of the probe shown in Fig. 2 covered by a sheath and having a switch assembly mounted thereon;
Fig. 5 is a top plan view, with portions broken away, of the probe shown in Fig. 2 covered by a drape and with a switch assembly shown optionally mounted thereon;
4 Fig. 6 is a perspective view of the removable switch assembly that is mounted on the probe shown in Fig. 2;
Fig. 7 is an exploded perspective view of the switch assembly shown in Fig. 6;
s Fig. 8 is a front view of the housing of the control unit of the present invention;
Fig. 9 is a front perspective view of a movable stand for mounting the control unit of the radiation detection apparatus of Fig. 1; and Fig. 10 is a rear perspective view, with portions broken away, of the io control unit and stand shown in Fig. 9.

DETAILED DESCRIPTION OF THE INVENTION
Referring to the drawings and, in particular, Fig. 1, there is a schematic of a preferred embodiment of the radiation detection apparatus 1s of the present invention, generally represented by reference number 10.
Apparatus 10 includes a hand-held radiation detection device or probe 50, and a control unit 100 connected to probe 50 by a suitable connection, such as a flexible cable 12. Probe 50 includes a radiation detector 52, a handle 54, and a shaft 56 that connects detector 52 to handle 54. Detector 20 52 includes a crystal, such as a cadmium telluride crystal, for detecting radiation, such as gamma protons, emitted from a radiation source in a patient's body. The radiation source is a scintillation fluid preferably containing technetium 99.
Probe 50 converts the detected scintillation radiation into electrical 25 pulses that are amplified and transmitted through cable 12 to control unit 100. Removably mounted to probe 50 is a switch assembly 70. Assembly 70 preferably has two switches 72, 74. Switches 72, 74 are preferably push button switches.
Activation of switch 72 enables a count accumulator module 158, 3o described below, to accumulate a scintillation count over a preset time period, such as ten seconds. Otherwise, scintillation counts are accumulated over succeeding one second periods. The scintillation pulses detected by probe 50 pass from the probe through cable 12 to a pulse shaping circuit 150 where the scintillation pulses are shaped. The shaped pulses are fed to a discriminator 152 which passes pulses that fall within an energy window that has been preset for technetium 99 by an energy window set 154. The pulses passed by discriminator 152 are fed to an s audio unit 156 where they are broadcast to aid the probe operator in positioning probe 50.
Pulses from discriminator 152 are also fed to a counter, for example a count accumulator module 158. Module 158 counts the scintillation pulses and averages them, in the normal operational mode, over io succeeding one second periods, or over a preset period, such as a ten second period, if selected by the probe operator's activation of switch 72 instead of pressing button 108 on control unit 100. The accumulated and averaged count value is passed from count accumulator module 158 to a display unit 160 that displays the averaged count value for each one 15 second period, or for the preset 10 second period.
Upon activation of switch 74 on probe 50, the accumulated and averaged count value is also passed from module 158 through a download control 162 and output to a terminal, here shown as output terminal 164.
Output terminal 164 can be connected to a utilization device, such as a 2o recorder 166. Output terminal 164 may also be connected, directly or remotely, to a computer 168. Computer 168 can be, for example, a personal computer, laptop, or other computing device, for storage and manipulation of the output data.
The electronic signals sent by control unit 100 to computer 168 25 represents the ten second count frozen and shown on display 160. Signals received by computer 168 will be received by its software which will record the signals, for example, to keep patient records of how control unit 100 was used (settings, duration, etc.). The software can be tailored to individual preferences or to established clinical protocols. However, control 30 unit 100 and probe 50 must be kept electrically isolated from computer 168, and the computer must not be able to control, program or otherwise affect the performance of the control unit or the probe. Thus, a unidirectional (control unit 100 to computer 168) isolated interface, e.g. optical coupler (represented by the heavy dashed line 11) is employed should the computer be connected to output terminal 164.
After a patient has been injected with a radiation emitting substance, for example, a scintillation liquid containing technetium 99, hand-held probe 50 is held stationary in position over a radiation detection site on the patient's body. A count is taken of the scintillation detected at that site for a given time period. This process is repeated at one or more different sites, or for different angular positions of the probe on the same site, and a io comparison is made of the counts obtained at each site. With switch 72 in a deactivated position, scintillations are detected or sampled over a series of first count sampling periods. Each sample period is, for example, preferably of one second duration. The signals or pulses transmitted from probe 50 during each one second period cause count accumulator module ts 158 to accumulate a scintillation count that is an average of the scintillation pulses over the one second period.
Control unit 100 is set such that activation of switch 72 initiates a ten second count sampling period, followed by a three second freeze period of the average count taken for the ten second period. During the ten second 20 sampling period, module 158 accumulates and averages the scintillation counts taken over the ten second period. The average count is displayed on display 160 for the three second freeze period. During the sampling period, a sampling light (not shown) on control unit 100 will flash. At the end of the sampling period, the sampling light goes off and a single audible 25 beep is emitted. If, during the three second freeze period, switch 74 is activated by the operator, the frozen count is downloaded from module 158 to output terminal 164 which sends the frozen count to a utilization device.
When switch 74 is activated during the three second period, two audible beeps are emitted. If switch 74 is not activated during the freeze 30 period, no downloading of the frozen count occurs. Switch 74 can be activated during or at the end of any one second count sampling period or, as stated above, during the three second freeze period. Thus, activation of switch 74 downloads the ten second count value to output terminal 164, and an audible signal indicates that the download has occurred. If switch 74 is not activated during the three second freeze period, module 158 returns to its normal mode of accumulating and averaging sampled counts per second and displaying the counts per second on display 160.
Control unit 100 is powered by a removable, rechargeable battery.
The preferred battery is a lead-acid rechargeable battery capable of four hours of continuous operation. When a predetermined set period of time of power battery life remains, such as, for example, fifteen minutes, a warning io indicator, such as a light, will flash or indicate the commencement of that set period. Accordingly, the user can simply insert a second battery in the control unit 100 to operate the control unit, and the first battery can simply be recharged when desired.
As shown in Fig. 2, switch assembly 70 is removably mounted on 1s handle 54 of probe 50. Switch assembly 70 preferably has two finger-operated push button switches 72, 74.
Referring to Fig. 3, probe 50 may have a removable protective cover 60 placed thereover. The protective cover 60 preferably is a sheath that substantially fully encompasses probe 50 to protect it from being soiled or 20 contaminated during storage and use. Sheath 60 permits probe 50 to be re-used without prior sterilization. Sheath 60 has a closed end 62 that covers detector 52, and an opposite open end 64 that can be at any desired location beyond handle 54. Preferably, sheath 60 is long enough to the entire length of cable 12, as shown in Fig. 2.
25 Sheath 60 can have any suitable size, shape and configuration.
Thus, it can fit loosely, tightly or form-fitted or even shrunk onto probe 50.
As shown in Fig. 4, sheath 60 preferably fits sufficiently tightly onto probe 50, especially about detector 52, to minimize interference with its function.
Sheath 60 preferably also fits tightly about the portion of handle 54 onto 30 which switch assembly 70 is to be mounted, to enable the switch assembly to remain tightly and securely mounted onto the handle. Sheath 60 can be made of any suitable material or materials, and can be single or multiple layered. Preferably, sheath 60 is made from a flexible film or sheet. The preferred material for sheath 60 is a single layer of polyurethane.
Although sheath 60 is the preferred cover, any suitable cover can be employed that permits switch assembly 70 to be effectively mounted onto probe 50. The sheath 60 is removable and preferably disposable and easily replaceable. Thus, as shown in Fig. 5, a drape 66 of flexible film can be placed over and secured to probe 50. As shown in Fig. 5, a continuous portion of drape 66 can be placed over detector 52, tied around shaft 56 by a tie 68, and gathered and secured about handle 54 or about cable 12 (not io shown) by any suitable member, such as by a clip 69. Switch assembly 70 (dashed line) can be mounted on probe 50 while the switch assembly is covered by drape 66.
Referring to Fig. 6, switch assembly 70 preferably has a saddle 76 formed by a curved undersurface 78 and a pair of spaced opposed js cooperative depending gripping members 80 that are adapted to releasably grip probe 50 (not shown) between them. Gripping members 80 are arcuately shaped and sized to fit tightly about handle 54 of probe 50.
Gripping members 80 are rigid enough to hold probe 50 between them, but resilient enough to allow the switch assembly 70 to be removed from the 20 probe.
As shown in Fig. 7, the preferred switch assembly 70 also has a cover 82, button switches 72, 74, a carrier in the form of a mounting member 84 having saddle 76, a recessed panel 86, and an insulating member 88 that fits into recessed panel 86 and insulates the switches and 25 any electrical wiring and connections (not shown) from probe 50 (not shown). In a preferred embodiment, there are two switches 72, 74.
However, it is possible that these switches may be combined into a single switch or that a third or more switches may be added to control remotely other functions of control unit 100. =
30 Referring to Fig 8, housing 212 of control unit 100 has a power button 102, a plurality of holes 104, preferably three, for operatively receiving a three prong plug of cable 12, a receiver 106 for operatively receiving a plug connected to probe 50, and a digital display 130. Housing 212 also has a button 108, which is preferably a push button, that initiates the ten second count time period, a light 110 that lights during the ten second period, a calibration indicator 112, and a battery charge indicator light 114. Housing 212 also has a volume control knob 116, a plurality of volume indicators 118, preferably light indicators, a knob to deactivate an internal threshold and window pre-set for technetium 99 to permit setting a wider window, a light indicator 122 for the internal threshold, and an audio range knob 124 to change the audio range from among the three values io indicated by lights 126, 128 and 130. Referring to Figs. 6 and 8, when switch 72 of switch assembly 70 is activated, button 108 is activated and, thus, light 110 is activated. When switch 74 is activated to download or record a count, an audible signal is provided.
Figs. 9 and 10 show a movable stand 200 suitable for use with radiation detection apparatus 10 of the present invention. Stand 200 has an upper vertical shaft 202 telescopically seated with a lower vertical shaft 204. Shaft 204 is mounted at its bottom end onto the hub of a plurality of radially outwardly extending legs 206 supported on rotatable wheels 208.
Shaft 202 is held at a desired height by an adjustable restrainer 205 on the top end of shaft 204. The upper end of shaft 202 has an adjustable fastener 210 mounted thereon. Fastener 210 has a horizontal shaft (not shown) onto which the lower end 211 of a bracket 214 is rotatably mounted. A housing 212 of control unit 100 is secured to bracket 214.
Bracket 214 and housing 212 can be tilted up and down to a desired angle about the shaft of fastener 210 and held at the desired angle by tightening threaded bolt 215.
Lower shaft 204 preferably has a pair of holders 220 mounted thereon. Each holder 220 has a pair of spaced, vertically disposed opposed holding members 222 adapted, e.g. shaped, to receive and releasably hold probe 50. Each holder 220 is positioned within a protective box 224 having a cover 226. Lower shaft 204 preferably has a support 228 for supporting cable 12 for probe 50. Onto the rear of lower shaft 204, ~o there is preferably fixedly mounted the lower end of an elongated bracket 230. Bracket 230 has a platform 232 welded or otherwise fixed thereto.
Platform 232 preferably is for supporting an auxiliary component such as a computer (not shown). The side of housing 212 has an angularly disposed rectangular cavity at 234 for holding and accessing the replaceable rechargeable battery (not shown) to supply power to control unit 100.
The present invention having been thus described with particular reference to the preferred forms thereof, it will be obvious that various changes and modifications may be made therein without departing from the io spirit and scope of the present invention as defined in the appended claims.

.
t~

Claims (4)

1. A hand-held radiation detection probe for use in detecting radiation emitted from a radiation emitting substance in a patient's body, said probe having a removable protective cover thereover to protect said probe from contamination during storage or use; a handle; and a switch assembly; wherein the cover covers said handle, and the switch assembly is removably mounted onto said handle over said cover.
2. The probe of claim 1, wherein said cover permits said probe to be re-used without prior sterilization.
3. The probe of claim 1, wherein said probe is elongated, and has a detector at one end and the handle at the other end, and said cover is a flexible sheath closed at one end about said detector and said cover is open at its opposed end beyond said handle.
4. The probe of claim 1, wherein said cover is a drape.
CA2638740A 1998-10-23 1999-10-21 Radiation detection apparatus Expired - Fee Related CA2638740C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/177,636 US6242741B1 (en) 1998-10-23 1998-10-23 Radiation detection apparatus
US09/177,636 1998-10-23
CA002347622A CA2347622C (en) 1998-10-23 1999-10-21 Radiation detection apparatus

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002347622A Division CA2347622C (en) 1998-10-23 1999-10-21 Radiation detection apparatus

Publications (2)

Publication Number Publication Date
CA2638740A1 CA2638740A1 (en) 2000-05-04
CA2638740C true CA2638740C (en) 2010-06-01

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Family Applications (6)

Application Number Title Priority Date Filing Date
CA2638740A Expired - Fee Related CA2638740C (en) 1998-10-23 1999-10-21 Radiation detection apparatus
CA2682274A Expired - Fee Related CA2682274C (en) 1998-10-23 1999-10-21 Radiation detection apparatus
CA002347622A Expired - Fee Related CA2347622C (en) 1998-10-23 1999-10-21 Radiation detection apparatus
CA002638738A Expired - Fee Related CA2638738C (en) 1998-10-23 1999-10-21 Radiation detection apparatus
CA002638736A Abandoned CA2638736A1 (en) 1998-10-23 1999-10-21 Radiation detection apparatus
CA002647875A Expired - Fee Related CA2647875C (en) 1998-10-23 1999-10-21 Radiation detection apparatus

Family Applications After (5)

Application Number Title Priority Date Filing Date
CA2682274A Expired - Fee Related CA2682274C (en) 1998-10-23 1999-10-21 Radiation detection apparatus
CA002347622A Expired - Fee Related CA2347622C (en) 1998-10-23 1999-10-21 Radiation detection apparatus
CA002638738A Expired - Fee Related CA2638738C (en) 1998-10-23 1999-10-21 Radiation detection apparatus
CA002638736A Abandoned CA2638736A1 (en) 1998-10-23 1999-10-21 Radiation detection apparatus
CA002647875A Expired - Fee Related CA2647875C (en) 1998-10-23 1999-10-21 Radiation detection apparatus

Country Status (7)

Country Link
US (5) US6242741B1 (en)
EP (1) EP1131652B1 (en)
JP (2) JP4343444B2 (en)
AU (1) AU772608B2 (en)
CA (6) CA2638740C (en)
DE (1) DE69929237T2 (en)
WO (1) WO2000025150A1 (en)

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CA2647875C (en) 2010-01-05
US6242741B1 (en) 2001-06-05
AU772608B2 (en) 2004-05-06
US20060054826A1 (en) 2006-03-16
CA2638740A1 (en) 2000-05-04
EP1131652A1 (en) 2001-09-12
US20010013576A1 (en) 2001-08-16
CA2682274A1 (en) 2000-05-04
AU1226700A (en) 2000-05-15
JP4343444B2 (en) 2009-10-14
US7126125B2 (en) 2006-10-24
US6534770B2 (en) 2003-03-18
CA2638738C (en) 2009-06-09
DE69929237T2 (en) 2006-08-17
CA2638736A1 (en) 2000-05-04
US20030183768A1 (en) 2003-10-02
CA2347622C (en) 2009-05-19
US20040238748A1 (en) 2004-12-02
CA2638738A1 (en) 2000-05-04
US7049599B2 (en) 2006-05-23
JP4503683B2 (en) 2010-07-14
EP1131652A4 (en) 2002-07-03
CA2347622A1 (en) 2000-05-04
US6984826B2 (en) 2006-01-10
WO2000025150A1 (en) 2000-05-04
CA2647875A1 (en) 2000-05-04
EP1131652B1 (en) 2005-12-28
JP2009168828A (en) 2009-07-30
JP2002528729A (en) 2002-09-03
CA2682274C (en) 2012-05-22
DE69929237D1 (en) 2006-02-02

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