CA2638781A1 - Sealed containers and methods of making and filling same - Google Patents

Sealed containers and methods of making and filling same Download PDF

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Publication number
CA2638781A1
CA2638781A1 CA002638781A CA2638781A CA2638781A1 CA 2638781 A1 CA2638781 A1 CA 2638781A1 CA 002638781 A CA002638781 A CA 002638781A CA 2638781 A CA2638781 A CA 2638781A CA 2638781 A1 CA2638781 A1 CA 2638781A1
Authority
CA
Canada
Prior art keywords
injection member
thermally resealable
container
resealable portion
recited
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002638781A
Other languages
French (fr)
Other versions
CA2638781C (en
Inventor
Daniel Py
Norbert M. Assion
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medinstill Development LLC
Original Assignee
Medical Instill Technologies, Inc.
Daniel Py
Norbert M. Assion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Instill Technologies, Inc., Daniel Py, Norbert M. Assion filed Critical Medical Instill Technologies, Inc.
Publication of CA2638781A1 publication Critical patent/CA2638781A1/en
Application granted granted Critical
Publication of CA2638781C publication Critical patent/CA2638781C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1431—Permanent type, e.g. welded or glued
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/04—Methods of, or means for, filling the material into the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/02—Machines characterised by the incorporation of means for making the containers or receptacles
    • B65B3/027—Making containers from separate body and end-parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B51/00—Devices for, or methods of, sealing or securing package folds or closures; Devices for gathering or twisting wrappers, or necks of bags
    • B65B51/10—Applying or generating heat or pressure or combinations thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/08—Sterilising wrappers or receptacles prior to, or during, packaging by irradiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B7/00—Closing containers or receptacles after filling
    • B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
    • B65B7/161—Sealing filled ampoules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2055—Connecting means having gripping means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus
    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B39/00—Nozzles, funnels or guides for introducing articles or materials into containers or wrappers
    • B65B2039/009—Multiple outlets

Landscapes

  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Basic Packing Technique (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)

Abstract

A medicament vial assembly includes a storage vial (310), a stopper member (330) and a securing ring (350, 370). The storage vial has a body portion (312) which defines an interior chamber (318) for storing a predetermined medicament and a neck portion through which medicament is received into and withdrawn from the interior chamber. The stopper member (330) is inserted into the mouth of the vial and establishes a first seal. The securing ring (350, 370) is engaged with the mouth of the vial and adapted and configured for retaining the stopper member (330) within the vial mouth and effectuating a second seal.

Claims (27)

1. A method comprising the following steps:
providing a container including a container body, a thermally resealable portion fusible in response to the application of thermal energy thereto, wherein the body defines an empty chamber sealed with respect to ambient atmosphere, and in fluid communication with the thermally resealable portion for receiving therein a predetermined substance, a base, a mid-portion, and an upper portion axially spaced from the base on an opposite side of the mid-portion relative to the base, wherein each of the base and upper portion define a laterally-extending dimension greater than a maximum laterally-extending dimension of the mid-portion;
penetrating the thermally resealable portion with an injection member coupled in fluid communication with a source of predetermined substance;
introducing the predetermined substance through the injection member and into the chamber of the container, withdrawing the injection member from the thermally resealable portion;
engaging the base of the body with a support during the step of withdrawing the injection member and substantially preventing axial movement of the body relative thereto, and applying sufficient energy to the thermally resealable portion to thermally fuse the penetrated region and form a substantially gas-tight seal between the penetrated region and the chamber.
2. A method as recited in claim 1, further comprising the step of engaging the support and the upper portion of the vial during withdrawal of the injection member to further prevent axial movement of the body.
3. A method as recited in claim 1, further comprising the step of sterilizing the empty assembled container prior to introducing the predetermined substance therein.
4. A method as recited in claim 3, wherein the step of sterilizing the empty container prior to introducing the predetermined substance includes at least one of applying gamma radiation, e-beam radiation or laser radiation thereto.
5. A method as recited in claim 1, further comprising the step of fusing a tamper-resistant portion between the thermally resealable portion and the container body.
6. A method as recited in claim 1, further comprising the step of over-molding a tamper-resistant portion to the thermally resealable portion and container body.
7. A method as recited in claim 1, further comprising the step of forming a tamper-resistant portion integral with the thermally resealable portion and over molding the integral thermally resealable portion and tamper-resistant portion to the container body.
8. A method as recited in claim 1, further comprising the steps of assembling the thermally resealable portion and container body robotically and over-molding a tamper-resistant portion to the thermally resealable portion and container body.
9. A method as recited in claim 8, wherein the assembly of the container body and thermally resealable portion occurs prior to installing the container body/thermally resealable portion assembly in a molding apparatus.
10. A method as recited in claim 8, wherein the container body and thermally resealable portion are assembled in an over-molding apparatus.
11. A method as recited in claim 1, further comprising the step of orienting at least one of an axis of the container and an axis of the injection member at an acute angle relative to the other defining an injection member penetration axis through the thermally resealable portion oriented at an acute angle relative to the axis of the container.
12. A method as recited in claim 11, further comprising the step of introducing the substance through the injection member at said acute angle and against a lateral wall of the body to facilitate substantially. laminar floe of the substance into the chamber.
13. A method comprising the following steps forming a container body defining a chamber in a first mold in a clean room environment;

forming a stopper in a second mold in the same clean room environment as the first mold, wherein the stopper is a thermoplastic stopper defining a needle penetration region that is pierceable with a needle to form a needle aperture therethrough, and is heat resealable to hermetically seal the needle aperture by applying laser radiation at a predetermined wavelength and power thereto; and assembling the stopper and container body in the clean room environment to form a sealed empty container.
14. A method as defined in claim 13, wherein the first and second molds are located side-by-side within the clean room environment
15. A method as defined in claim 13, further comprising the following steps.

penetrating the needle penetration region of the stopper with a filling needle such that the filling needle is in fluid communication with the chamber of the container;

introducing the substance through the needle and into the chamber of the container;
withdrawing the filling needle from the stopper, and transmitting laser radiation at the predetermined wavelength and power onto an aperture formed in the needle penetration region of the stopper, and hermetically sealing the aperture.
16. A method as defined in claim 13, further comprising the step of sterilizing, the sealed empty container between the assembling and penetrating steps
17. A method comprising the following steps:

forming a body defining a chamber in a first mold in a clean room environment;

forming a penetrable and thermally resealable portion in a second mold in the same clean room environment as the first mold, wherein the penetrable and thermally resealable portion is formed of thermoplastic and defines a penetration region that is pierceable with an injection member to form a penetration aperture therethrough. and is heat resealable to hermetically seal the penetration aperture by applying, laser radiation at a predetermined wavelength and power thereto; and assembling the penetrable and thermally resealable portion and body in the clean room environment to form a sealed empty assembly.
18. A method as defined in claim 17, wherein the first and second molds are located side-by-side within the clean room environment.
19. A method as defined in claim 17. further comprising the following steps:

penetrating the penetration region of the penetrable and thermally resealable portion with an injection member such that the injection member is in fluid communication with the chamber of the assembly;

introducing the substance through the injection member and into the chamber of the assembly;

withdrawing the injection member from the penetrable and thermally resealable portion;
and transmitting laser radiation at the predetermined wavelength and power onto an aperture formed in the penetrable and thermally resealable portion. and hermetically sealing the aperture.
20. A method as defined in claim 17. further comprising the following steps:

forming a body defining a base. a mid-portion. and an upper portion axially spaced from the base on an opposite side of the mid-portion relative to the base. wherein each of the base and upper portion define a laterally-extending dimension greater than a maximum laterally-extending dimension of the mid-portion; and engaging the base of the body with a support during the step of withdrawing the injection member and substantially preventing axial movement of the body relative thereto.
21. A method as defined in claim 20. further comprising the step of engaging the support and the upper portion of the body during withdrawal of the injection member to further prevent axial movement or the body.
24. A method as defined in claim 20, further comprising the step of sterilizing the empty assembly prior to introducing the substance therein.
23. A method as defined in claim 24, wherein the step the empty assembly prior to introducing the substance includes at least one of applying gamma radiation, e-beam radiation and laser radiation thereto.
24. A method as defined in claim 17. further comprising the step of fusing a tamper-resistant portion between the penetrable and thermally resealable portion and body.
25. A method as defined in claim 17. further comprising the step of over-molding a tamper-resistant portion to the penetrable and thermally resealable portion and body.
26. A method as defined in claim 19. further comprising the step of orienting at least one of an axis of the body and an axis of the injection member at an acute angle relative to the other defining an injection member penetration axis through the penetrable and thermally resealable portion oriented at an acute angle relative to the axis of the body.
27. A method as defined in claim 26, further comprising the step of introducing the substance through the injection member at said acute angle and against a lateral wall of the body to facilitate substantially laminar flow of the substance into the chamber.
CA 2638781 2002-09-03 2003-09-03 Sealed containers and methods of making and filling same Expired - Fee Related CA2638781C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40806802P 2002-09-03 2002-09-03
US60/408,068 2002-09-03
CA002497664A CA2497664C (en) 2002-09-03 2003-09-03 Sealed containers and methods of making and filling same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002497664A Division CA2497664C (en) 2002-09-03 2003-09-03 Sealed containers and methods of making and filling same

Publications (2)

Publication Number Publication Date
CA2638781A1 true CA2638781A1 (en) 2004-04-01
CA2638781C CA2638781C (en) 2010-02-02

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA002497664A Expired - Fee Related CA2497664C (en) 2002-09-03 2003-09-03 Sealed containers and methods of making and filling same
CA 2638781 Expired - Fee Related CA2638781C (en) 2002-09-03 2003-09-03 Sealed containers and methods of making and filling same

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Application Number Title Priority Date Filing Date
CA002497664A Expired - Fee Related CA2497664C (en) 2002-09-03 2003-09-03 Sealed containers and methods of making and filling same

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US (8) US7100646B2 (en)
EP (2) EP2546152A3 (en)
JP (5) JP4425140B2 (en)
KR (1) KR100644331B1 (en)
CN (2) CN101001782A (en)
AU (2) AU2003299041B2 (en)
BR (1) BRPI0313992B1 (en)
CA (2) CA2497664C (en)
CO (1) CO5720985A2 (en)
IL (4) IL167224A (en)
MX (1) MXPA05002458A (en)
NO (1) NO20051624L (en)
NZ (1) NZ538754A (en)
PL (1) PL375626A1 (en)
RU (2) RU2379217C2 (en)
WO (1) WO2004026695A2 (en)
ZA (1) ZA200502121B (en)

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US7669390B2 (en) * 2004-03-08 2010-03-02 Medical Instill Technologies, Inc. Method for molding and assembling containers with stoppers and filling same
US7707807B2 (en) * 2004-03-08 2010-05-04 Medical Instill Technologies, Inc. Apparatus for molding and assembling containers with stoppers and filling same
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CA2489804C (en) 2002-06-19 2008-03-25 Medical Instill Technologies, Inc. Sterile filling machine having needle filling station within e-beam chamber
MXPA05002458A (en) 2002-09-03 2005-09-30 Medical Instill Tech Inc Sealed containers and methods of making and filling same.
CN102145774B (en) * 2003-01-28 2013-08-21 因斯蒂尔医学技术有限公司 Method for filling the vial
WO2004096113A2 (en) 2003-04-28 2004-11-11 Medical Instill Technologies, Inc. Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
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