CA2649999A1 - Contact free absolute position determination of a moving element in a medication delivery device - Google Patents

Contact free absolute position determination of a moving element in a medication delivery device Download PDF

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Publication number
CA2649999A1
CA2649999A1 CA002649999A CA2649999A CA2649999A1 CA 2649999 A1 CA2649999 A1 CA 2649999A1 CA 002649999 A CA002649999 A CA 002649999A CA 2649999 A CA2649999 A CA 2649999A CA 2649999 A1 CA2649999 A1 CA 2649999A1
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CA
Canada
Prior art keywords
transmitter
electrodes
delivery device
medication delivery
receiver electrodes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002649999A
Other languages
French (fr)
Inventor
Preben Nielsen
Bodo Von Munchow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Preben Nielsen
Bodo Von Munchow
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Preben Nielsen, Bodo Von Munchow, Novo Nordisk A/S filed Critical Preben Nielsen
Publication of CA2649999A1 publication Critical patent/CA2649999A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D5/00—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable
    • G01D5/12—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means
    • G01D5/14—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage
    • G01D5/24—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance
    • G01D5/241—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance by relative movement of capacitor electrodes
    • G01D5/2412—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance by relative movement of capacitor electrodes by varying overlap
    • G01D5/2415—Mechanical means for transferring the output of a sensing member; Means for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for converting; Transducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying capacitance by relative movement of capacitor electrodes by varying overlap adapted for encoders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/31581—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle

Abstract

The present invention relates to a medication delivery device for expelling set doses of medicament, the medication delivery device comprising a position determining assembly for detecting absolute positions of a rotatably mounted member arranged within the device, the position determining assembly comprising a plurality of transmitter electrodes arranged on a first exterior surface part of the rotatably mounted member, a plurality of receiver electrodes arranged on a second exterior surface part of the rotatably mounted member. A number of transmitter electrodes form pairs of interconnected electrodes with a number of receiver electrodes. A reading assembly fixedly arranged relative to for example the housing of the medication delivery device is also provided. The reading assembly comprises a plurality of transmitters arranged to electrically couple to one or more receiver electrodes, the reading assembly further comprising a plurality of receivers arranged to electrically couple to one or more transmitter electrodes.

Description

CONTACT FREE ABSOLUTE POSITION DETERMINATION OF A MOVING ELEMENT IN A
MEDICATION DELIVERY DEVICE

FIELD OF THE INVENTION

The present invention relates to an assembly and a method for determining an absolute position of a first member, such as a rotatably mounted dose indication barrel, in a medication delivery device. In particular, the present invention relates to an assembly which takes up a minimum amount of space.

BACKGROUND OF THE INVENTION

US 4,420,754 discloses a system for measuring the relative movement between two elements, such as the scale and slide of a hand-held measuring instrument. The system includes the provision of a number of groups of supply electrodes on the slide, each of the electrodes in each group being supplied from a respective one of a multiple number of output signals from a signal generator so that all of the supply electrodes are furnished with voltages according to a cyclic pattern, the slide also having at least one receiving electrode which feeds a signal processing unit. The scale is provided with an electronic pattern comprising internally galvanically connected parts, one being a detecting part, located close to the area where the supply electrodes of the slide are moved, the other of the two parts being a transferring part which is located close to the area where the receiving electrode of the slide is moved. The movement of the slide along the scale generates a signal from the receiving electrode which is derived from the signals from at least two adjacent supply electrodes and the position of the slide is determined by a signal processing unit which identifies the amplitude ratio of the received signals.

US 6,329,813 discloses an inductive absolute position sensor applying at least one magnetic field generator that generates a first changing magnetic flux in a first flux region. A plurality of coupling loops have a first plurality of coupling loop portions spaced at an interval related to a first wavelength along a measuring axis and a second plurality of coupling loop portions spaced at an interval related to a second wavelength along a measuring axis.
One of the first plurality of coupling loop portions and the second plurality of coupling loop portions are inductively coupled to a first changing magnetic flux from a transmitter winding in a first flux region to generate a second changing magnetic flux outside the first flux region in the other of the first plurality of coupling loop portions and the second plurality of coupling loop portions. A magnetic flux sensor is positioned outside the first flux region and is responsive to the second changing magnetic flux to generate a position-dependent output signal. The output signal varies at the first or second wavelength of the corresponding other of the first plurality of coupling loop portions and the second plurality of coupling loop portions that generates the second changing magnetic flux.

The arrangements suggested in both US 4,420,754 and US 6,329,813 are adapted for determining linear translations between two objects.

US 2004/0207385 relates to a device for detecting the position of a rotor relative to a stator, wherein at least one electrode is arranged on the rotor and at least one electrode is arranged on the stator, such that the electrodes at least partially overlap in at least one rotational position of the rotor relative to the stator. US 2004/0207385 further relates to a method for measuring the rotational position of a rotor comprising at least one rotor electrode relative to a stator comprising at least one stator electrode, wherein the rotational position is detected using a capacitive coupling between the rotor electrode and the stator electrode.

US 2004/0207385 relates to the determining of angular positions between two objects such as between a rotatably mounted rotor and a stationary stator. It is a disadvantage of the arrangement suggested in US 2004/0207385 that the emitters and receivers are position in a manner where they take up an unnecessary amount of space. For compact systems the solution suggested by US 2004/0207385 is not applicable.

Furthermore, the arrangement suggested in US 2004/0207385 is not adapted for contact free and absolute position determination. As depicted in figures 8 and 9 of US
2004/0207385 and the corresponding text in paragraphs 0053 and 0054 additional components such as force sensors or electrical resistors are required if absolute measurements are to be performed.
Thus, it is a disadvantage of the arrangement suggested in 2004/0207385 that absolute measurements cannot be performed without the adding of contact requiring elements, such as force sensors and electrical resistors - the latter being implemented as a voltage divider.
It is an object of the present invention to provide a space saving assembly for measuring an absolute position, such as an absolute angular position, of a rotatably mounted member, such as a dose indicator barrel, in a medication delivery device.

SYMMARY OF THE INVENTION

The above-mentioned object is complied with by providing, in a first aspect, a medication delivery device comprising a position determining assembly for detecting absolute positions of a first member relative to a second member of the medication delivery device, the position determining assembly comprising - a plurality of transmitter electrodes arranged on the first member, the plurality of transmitter electrodes being arranged along a substantially helical path, - a plurality of receiver electrodes arranged on the first member, the plurality of receiver electrodes being arranged along a substantially helical path, wherein a number of transmitter electrodes form pairs of interconnected electrode elements with a number of receiver electrodes, and - a reading assembly fixedly arranged relative to the second member, the reading assembly comprising a plurality of transmitters arranged to electrically couple to one or more receiver electrodes of the first member, and a plurality of receivers arranged to electrically couple to one or more transmitter electrodes of the first member.

The first member may comprise a rotatably mounted member, such as a rotatably mounted dose indication barrel, whereas the second member may form part of a housing of the medication delivery device. The rotatably mounted dose indicator barrel may be arranged to rotate about, and displace along, a centre axis of the medication delivery device, said centre axis also defining a centre axis of the housing of the medication delivery device.
Interconnected pairs of transmitter and receiver electrodes of the first member may be galvanically isolated from other interconnected pairs of transmitter and receiver electrodes.
Thus, according to the present invention electrode elements of interconnected pairs of transmitter and receiver electrodes are provided along a substantially helical-shaped path.

Along the above-mentioned substantially helical-shaped path the transmitter electrodes may form a first periodic pattern. Similarly, the receiver electrodes may form a second periodic pattern along the substantially helical-shaped path. According to the present invention a periodicity of the first periodic pattern may be different from a periodicity of the second periodic pattern. Thus, according to the present invention the transmitter and receiver electrodes are spatially shifted along the substantially helical-shaped path.
The total lengths of the first and second periodic patterns may be essentially the same and within the range 100-150 mm.

To ease access to the plurality of transmitter and receiver electrodes, said plurality of transmitter and receiver electrodes may be arranged on first and second exterior surface parts of the first member, respectively.

The first member may be adapted to perform a combined rotational and translational movement relative to the second member.
The electrical coupling between transmitters of the reading assembly and one or more receiver electrodes of the first member may comprise a capacitive coupling. In this situation, the electrodes forming the transmitters of the reading assembly and the one or more receiver electrodes of the first member may be implemented as capacitor plates. Also, the electrical coupling between receivers of the reading assembly and one or more transmitter electrodes of the first member may comprise a capacitive coupling between electrodes being formed as capacitor plates.

The reading assembly may comprise eight transmitters arranged in a row. The eight transmitters may be driven in pairs so that the same transmitter signal is provided to two parallel coupled transmitters. In a row of eight transmitters a first transmitter signal may be applied to the first and the fifth transmitter in the row, whereas a second transmitter signal may be applied to the second and the sixth transmitter in the row. Similarly, a third transmitter signal may be applied to the third and the seventh transmitter in the row, and a fourth transmitter signal may be applied to the fourth and the eighth transmitter in the row.
The first, second, third and fourth transmitter signals may be phase shifted relative to each other - for example by an angle of around 90 degrees. The reading assembly may further comprise two receivers. Each receiver may be arranged as a number of triangular-shaped electrodes.

The transmitters and the receivers of the reading assembly may be arranged on a flexible carrier, such as on a flex print. By arranging the reading assembly on a flexible carrier the shape of the reading assembly can be adjusted to fit the shape of the housing of the medication delivery device and the shape of the first member.

The medication delivery device according to the first aspect of the present invention may further comprise an electronic control circuit for generating and handling electrical signals to and from the transmitters and the receivers of the reading assembly, respectively.

As already mentioned, the first member may be a movably mounted member, such as a rotatably mounted dose indicator barrel positioned within the medication delivery device.
In a second aspect, the present invention relates to a method for determining absolute positions of a first member relative to a second member of a medication delivery device, the method comprising the steps of - providing a plurality of transmitter electrodes arranged on the first member, the plurality of transmitter electrodes being arranged along a substantially helical path, - providing a plurality of receiver electrodes arranged on the first member, the plurality of receiver electrodes being arranged along a substantially helical path, wherein a number of transmitter electrodes form pairs of interconnected electrode elements with a number of receiver electrodes, 5 - providing a reading assembly fixedly arranged relative to the second member, the reading assembly comprising a plurality of transmitters arranged to electrically couple to one or more receiver electrodes of the first member, and a plurality of receivers arranged to electrically couple to one or more transmitter electrodes of the first member, and - providing first, second, third and fourth transmitter signals to respective ones of first, second, third and fourth transmitters of the reading assembly, the first, second, third and fourth transmitter signals being mutually shifted in phase.

According to the method of the second aspect of the present invention, the first member may comprise a rotatably mounted member, such as a rotatably mounted dose indicator barrel, whereas the second member forms part of a housing of the medication delivery device. The rotatably mounted dose indicator barrel may be arranged to rotate about, and displace along, a centre axis of the medication delivery device, said centre axis also defining a centre axis of the housing of the medication delivery device.

A previously mentioned, the first, second, third and fourth transmitter signals may be approximately 90 degrees out of phase. The transmitter signals may be sinusoidal or PWM-generated signals having a fundamental frequency in the 1-100 kHz range.
However, transmitter signals having a fundamental frequency of around 10 kHz are preferable, especially if the transmitter signals are generated by PWM. The reason for this being that a 10 MHz signal is required in order to generate a suitable 10 kHz signal. In addition, the frequency of the transmitter signals is kept in the low end in order to reduce the influence of parasitic capacitances. Amplitude levels in the 1-5 V range, such as 1.5-3 V, may be applicable.

The first, second, third and fourth transmitter signals may be provided to respective pairs of transmitters. Thus, of a row comprising eight transmitters the first transmitter signal may be applied to a first and a fifth transmitter, whereas the second transmitter signal may be applied to a second and a sixth transmitter. Similarly, the third transmitter signal may be applied to a third and a seventh transmitter, whereas the fourth transmitter signal may be applied to a fourth and an eighth transmitter in the row.
The electrical coupling between transmitters of the reading assembly and one or more receiver electrodes of the first member may comprise a capacitive coupling.
Similarly, the electrical coupling between receivers of the reading assembly and one or more transmitter electrodes of the first member may comprise a capacitive coupling.

As previously mentioned, interconnected pairs of transmitter and receiver electrodes of the first member may be galvanically isolated from other interconnected pairs of transmitter and receiver electrodes. Thus, electrode elements of interconnected pairs of transmitter and receiver electrodes are provided along a substantially helical-shaped path.

Along the above-mentioned substantially helical-shaped path the transmitter electrodes may form a first periodic pattern. Similarly, the receiver electrodes may form a second periodic pattern along the substantially helical-shaped path. According to the present invention a periodicity of the first periodic pattern may be different from a periodicity of the second periodic pattern. Thus, according to the present invention the transmitter and receiver electrodes are spatially shifted along the substantially helical-shaped path.
The total lengths of the first and second periodic patterns may be essentially the same and within the range 100-150 mm.

To ease access to the plurality of transmitter and receiver electrodes, said plurality of transmitter and receiver electrodes may be arranged on first and second exterior surface parts of the first member, respectively.

In a third aspect, the present invention relates to a medication delivery device comprising a position determining assembly for detecting absolute positions of a first member relative to a second member of the medication delivery device, the position determining assembly comprising - coupling means adapted to receive and re-transmit an electrical signal coupled to said coupling means, said coupling means forming a substantially helical path on the first member, - transmitting means adapted to electrically couple one or more transmitter signals to the coupling means of the first member, said transmitting means being fixedly arranged relative to the second member, - receiving means adapted to receive re-transmitted electrical signals from the coupling means of the first member, said receiving means being fixedly arranged relative to the second member, and - electronic control means adapted to generate suitable transmitter signals, and to process receiver signals from the receiving means in order to determine an absolute position of the first member relative to the second member.

The coupling means of the first member may comprise a plurality of transmitter electrodes arranged on said first member, the plurality of transmitter electrodes being arranged along a substantially helical path. Furthermore, the coupling means may comprise a plurality of receiver electrodes arranged on said first member, the plurality of receiver electrodes being arranged along a substantially helical path. A number of transmitter electrodes may form pairs of interconnected electrode elements with a number of receiver electrodes.

The transmitting and receiving means may be incorporated into a reading assembly fixedly arranged relative to the second member. The reading assembly may comprise a plurality of transmitters arranged to electrically couple to one or more receiver electrodes of the first member, and a plurality of receivers arranged to electrically couple to one or more transmitter electrodes of the first member.

The first member may comprise a rotatably mounted member, such as a rotatably mounted dose indication barrel, whereas the second member may form part of a housing of the medication delivery device. The rotatably mounted dose indicator barrel may be arranged to rotate about, and displace along, a centre axis of the medication delivery device, said centre axis also defining a centre axis of the housing of the medication delivery device.

Further implementations of the reading assembly, the transmitter and receiver electrodes, the transmitter signals etc. may be as described in connection with the first and second aspects of the present invention.

BRIEF DESCRIPTION OF THE DRAWINGS

The present invention will now be explained with reference to the accompanying drawings, wherein Fig. 1 shows a reading assembly comprising two receivers and eight transmitters, and an associated scale comprising transmitter and receiver electrodes, Fig. 2 shows a reading assembly comprising two receivers and eight transmitters, and an associated scale comprising transmitter and receiver electrodes, where the transmitter electrodes are aligned with the receivers of the reading assembly and where the receiver electrodes are aligned with the transmitters of the reading assembly, Fig. 3 shows a print layout, Fig. 4 shows a scale comprising spatially displaced transmitter and receiver electrodes, Fig. 5 shows a control circuit capable of generating four transmitter signals and handling signals from two receivers, and Fig. 6 shows the positioning determining assembly according to the present invention mounted in a medication delivery device.

While the invention is susceptible to various modifications and alternative forms, specific embodiments have been shown by way of example in the drawings and will be described in detail herein. It should be understood, however, that the invention is not intended to be limited to the particular forms disclosed. Rather, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.

DETAILED DESCRIPTION OF THE INVENTION

In its broadest aspect the present invention relates to a medication delivery device comprising an assembly for determining the absolute position of a first member, such as a rotatably mounted dose indicator barrel, relative to a second member, such as a housing part of the medication delivery device. The assembly is implemented with the aim to take up minimum space within the medication delivery device.

The above-mentioned requirements are provided for by providing, in one embodiment of the present invention, an assembly comprising a reading assembly having eight transmitters arranged in a row. The eight transmitters are operated in pairs so that two transmitters are provided with the same transmitter signal. The transmitter signals provided to the four pairs of transmitters are phase shifted 90 degrees.

An assembly according to the above-mentioned embodiment of the present invention is depicted in Fig. 1 where the transmitters are denoted trl-tr4. In the assembly depicted in Fig. 1 a first transmitter signal is applied to both tr1-transmitters.
Similarly, a phase shifted second transmitter signal is applied to both tr2-transmitters. This second transmitter signal is phase shifted 90 degrees relative to the transmitter signal provided to the two tr1-transmitters. A phase shifted third transmitter signal is provided to the two tr3-transmitters, and finally, a phase shifted fourth transmitter signal is provided to the two tr4-transmitters.
In Fig. 1 S1 and S2 are two receivers.
The number of transmitters may differ from the above-mentioned eight. Thus, a number of twelve transmitters may be operated in pairs by applying six phase shifted transmitter signals. Such six phase shifted transmitters signals will be phase shifted 60 degrees..

The physical implementation of the transmitters tr1-tr4 and receivers S1, S2 are depicted in Fig. 3b where the transmitters and receivers are arranged a flexible PCB, such as on a flex print. As shown in Fig. 3a the transmitters and receivers are implemented on the same PCB
as the electronic control circuit capable of generating the required four phase shifted transmitter signals and handling/processing signals from the receivers. The electronic control circuit itself is shown in Fig. 5.
The detection principle associated with the assembly depicted in Fig. 1 is normally referred to as the displaced trace method. As seen, the reading assembly 1 consists of two main parts -a scale 2 (placed on an exterior surface part of for example a rotatably mounted dose indicator barrel or on another movable part) having two rows of rectangular electrodes (numbered n=-N, -N+1, .., -2,-1, 0, 1, 2,..,N), and the reading head (fixedly positioned relative to the housing of the medication delivery device) with generator/transmitter electrodes tr1-tr4 and the receiver electrodes S1 - S2.

Still referring to Fig. 1 the centre-to-centre distance between neighbouring electrodes of the upper row is larger than the centre-to-centre distance between neighbouring electrodes of the lower row, As seen in Fig. 1 each electrode of the upper row is electrically connected with an electrode of the lower row thereby forming an electrode element. As seen, the electrode elements are galvanically isolated from each other. When the scale of electrode elements is placed over or aligned with the reading assembly 1 (see Fig. 2), the signal from the transmitters tr1-tr4 is coupled to the receiver electrodes S1, S2 via the two rows of electrodes forming the scale. Thus, transmitter signals provided to transmitters tr1-tr4 are electrically coupled to electrodes of the lower row (receiver electrodes) of the scale 2, and re-transmitted from the upper electrodes (transmitter electrodes) of the scale 2 to be received by receivers S1, S2. Preferably, the electrical couplings between transmitters tr1-tr4 and receiver electrodes, and between the transmitter electrodes and receivers S1, S2 are capacitive.

The centre of the reading assembly (transmitters and receivers) and the scale is in Fig. 1 indicated by a dashed line. Thus, both the reading assembly and the scale are symmetric around this dashed line. Off-centre the two rows of electrodes forming the scale are displaced whereas in the centre of the scale (at the dashed line) the two rows of electrodes are aligned.
This arrangement of the electrodes influences the received signal in such a way that the phase of the signals from the two receiver electrodes S1, S2 are changing along the scale. In this way is it possible two perform an absolute measurement of the position of the reading assembly relative to the scale.

In the medication delivery device the space for the reading assembly is rather limited - the maximum length (along the scale direction) is 8.25 mm whereas the maximum allowable 5 height is 6 mm. With this limited space available a configuration comprising two groups of four transmitters tr1-tr4 are preferred. Each of the four transmitters tr1-tr4 transmits a sinusoidal-like transmitter signal and, as previously mentioned, the transmitters tr1-tr4 are driven out of phase. Thus, the transmitter signal provided to transmitter tr2 is phase shifted 90 degrees relative to tr1, the transmitter signal provided to transmitter tr3 is phase shifted 10 180 degrees relative to tr1 and, finally, the transmitter signal provided to transmitter tr3 is phase shifted 270 degrees relative to tr1.

By using two sets of transmitters tr1-tr4 two wavelengths of the transmitter signal are used along the scale length in the reading head. With two wavelengths of transmitters two wavelengths of receivers are available.

The maximum allowable displacement between the two electrode rows of the scale is given by the fact that the maximum phase difference between the signals from receivers S1 and S2 is t180 . This corresponds to a maximum displacement of t1/z wavelength of the transmitters. This maximum displacement of t1/z wavelength of the transmitters increases the length of the receiver from two to three wavelengths (two wavelengths +1/z wavelength at each end of the scale).

A maximum allowable total length of 8.25 mm distributed over 3 wavelengths result in a receiver wavelength of 2.75 mm. The length of curvature along a typical dose indicator barrel scale is 114 mm. However, this measure only applies for the centre point of the reading assembly. To compensate for this the length of the scale has to be increased with a length that corresponds to the length of the receivers. This gives a total scale length of 122.25 mm.
Thus, the distance from the centre point of the scale to both ends of the scale is 61.13 mm.
At the ends of the scale the displacement is 1/2 wavelength. Thus, the displacement factor is given by 1/2 wavelength divided by the half scale length causing the distance between the electrodes aligned with the receiver electrodes in the reading head to be 2.2%
higher than the distance between the electrodes aligned with the transmitter electrodes in the reading head.
A maximum allowable length of 8.25 mm spilt over 3 wavelengths combined with a displacement factor of 2.2 % gives a transmitter wavelength of 2.68 mm. Thus, the centre-to-centre distance between the transmitters is 0.66 mm.

One half of the scale is shown in Fig. 4 - the centre of the scale is at the position of the arrow. As seen, the displacement of the electrodes in the two rows increases in the direction of the end of the scale. It should be noted that the scale depicted in Fig. 4, when arranged on a rotatably mounted dose indicator barrel, will take a substantially helical shape in that the scale is preferably arranged on a substantially cylindrically shaped outer surface of the rotatably mounted dose indicator barrel. Furthermore, since the rotatably mounted dose indicator barrel should be allowed to rotate more than one revolution the scale will unavoidable form a substantially helical shape.

In Fig. 6 the position determining assembly according to the present invention is depicted.
Fig. 6 shows a housing 3 of a medication delivery device and an assembly holder 4 for holding the reading assembly 1 according to the present invention. As previously mentioned, the reading assembly 1 comprises eight transmitters (not shown) and two receivers (not shown). The reading assembly is implemented as depicted in the upper part of Fig. 1.

The reading assembly 1 is positioned on assembly holder 4 which can be displaced along a radial direction of the medication delivery device. In this way the reading assembly 1 can be brought into the vicinity of the exterior surface of a dose indicator barrel 5 upon which the scale (see Fig. 4) is arranged. Thus, then the dose indicator barrel is rotated it performs a combined rotational/translational movement in relation to the housing of the medication delivery device. This combined rotational/translational movement of the dose indicator barrel 5 causes the scale (see Fig. 4) to pass through the transmitters and the receivers of the reading assembly. Via a capacitive coupling the transmitters and the receivers, via the electrodes on the dose indicator barrel, an absolute position of the dose indicator barrel is determinable.

Claims (25)

1. A medication delivery device comprising a position determining assembly for detecting absolute positions of a first member relative to a second member of the medication delivery device, the position determining assembly comprising - a plurality of transmitter electrodes arranged on the first member, the plurality of transmitter electrodes being arranged along a substantially helical path, - a plurality of receiver electrodes arranged on the first member, the plurality of receiver electrodes being arranged along a substantially helical path, wherein a number of transmitter electrodes form pairs of interconnected electrode elements with a number of receiver electrodes, and - a reading assembly fixedly arranged relative to the second member, the reading assembly comprising a plurality of transmitters arranged to electrically couple to one or more receiver electrodes of the first member, and a plurality of receivers arranged to electrically couple to one or more transmitter electrodes of the first member.
2. A medication delivery device according to claim 1, wherein the first member comprises a rotatably mounted member, and wherein second member forms part of a housing of the medication delivery device.
3. A medication delivery device according to claim 1 or 2, wherein interconnected pairs of transmitter and receiver electrodes are galvanically isolated from other interconnected pairs of transmitter and receiver electrodes.
4. A medication delivery device according to any of claims 1-3, wherein the transmitter electrodes form a first periodic pattern along the helical path.
5. A medication delivery device according to any of claims 1-4, wherein the receiver electrodes form a second periodic pattern along the helical path, wherein a periodicity of the first periodic pattern is different from a periodicity of the second periodic pattern.
6. A medication delivery device according to any of claims 1-5, wherein the plurality of transmitter and receiver electrodes are arranged on first and second exterior surface parts of the first member, respectively.
7. A medication delivery device according to any of claims 1-6, wherein the first member is adapted to perform a combined rotational and translational movement relative to the second member.
8. A medication delivery device according to any of the preceding claims, wherein the electrical coupling between transmitters of the reading assembly and receiver electrodes of the first member comprises a capacitive coupling.
9. A medication delivery device according to any of the preceding claims, wherein the electrical coupling between receivers of the reading assembly and transmitter electrodes of the first member comprises a capacitive coupling.
10. A medication delivery device according to any of the preceding claims, wherein the reading assembly comprises eight transmitters.
11. A medication delivery device according to any of the preceding claims, wherein the reading assembly comprises two receivers.
12. A medication delivery device according to any of the preceding claims, wherein the transmitters and the receivers of the reading assembly are arranged on a flexible carrier, such as a flex print.
13. A medication delivery device according to any of the preceding claims, further comprising an electronic control circuit for generating and handling electrical signals to and from the transmitters and the receivers of the reading assembly, respectively.
14. A medication delivery device according to any of the preceding claims, wherein the first member comprises a rotatably mounted dose indicator barrel.
15. A method for determining absolute positions of a first member relative to a second member of a medication delivery device, the method comprising the steps of - providing a plurality of transmitter electrodes arranged on the first member, the plurality of transmitter electrodes being arranged along a substantially helical path, - providing a plurality of receiver electrodes arranged on the first member, the plurality of receiver electrodes being arranged along a substantially helical path, wherein a number of transmitter electrodes form pairs of interconnected electrode elements with a number of receiver electrodes, - providing a reading assembly fixedly arranged relative to the second member, the reading assembly comprising a plurality of transmitters arranged to electrically couple to one or more receiver electrodes of the first member, and a plurality of receivers arranged to electrically couple to one or more transmitter electrodes of the first member, and - providing first, second, third and fourth transmitter signals to respective ones of first, second, third and fourth transmitters of the reading assembly, the first, second, third and fourth transmitter signals being mutually shifted in phase.
16. A method according to claim 15, wherein the first member comprises a rotatably mounted member, and wherein second member forms part of a housing of the medication delivery device.
17. A method according to claim 15 or 16, wherein the first, second, third and fourth transmitter signals are approximately 90 degrees out of phase.
18. A method according to any of claims 15-17, wherein the electrical coupling between transmitters of the reading assembly and one or more receiver electrodes of the first member comprises a capacitive coupling.
19. A method according to any of claim 15-18, wherein the electrical coupling between receivers of the reading assembly and one or more transmitter electrodes of the first member comprises a capacitive coupling.
20. A method according to any of claims 15-19, wherein interconnected pairs of transmitter and receiver electrodes are galvanically isolated from other interconnected pairs of transmitter and receiver electrodes.
21. A method according to any of claims 15-20, wherein the transmitter electrodes form a first periodic pattern along the helical path.
22. A method according to any of claims 15-21, wherein the receiver electrodes form a second periodic pattern along the helical path, wherein a periodicity of the first periodic pattern is different from a periodicity of the second periodic pattern.
23. A method according to any of claims 15-22, wherein the plurality of transmitter and receiver electrodes are arranged on first and second exterior surface parts of the first member, respectively.
24. A method according to any of claims 15-23, wherein the first member is adapted to perform a combined rotational and translational movement relative to the second member.
25. A method according to any of claims 15-24, wherein the first member comprises a rotatably mounted dose indicator barrel.
CA002649999A 2006-04-26 2007-04-25 Contact free absolute position determination of a moving element in a medication delivery device Abandoned CA2649999A1 (en)

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EP06008597.4 2006-04-26
PCT/EP2007/054069 WO2007122253A1 (en) 2006-04-26 2007-04-25 Contact free absolute position determination of a moving element in a medication delivery device

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US8049519B2 (en) 2011-11-01
EP2013587A1 (en) 2009-01-14
WO2007122253A1 (en) 2007-11-01
JP2009534147A (en) 2009-09-24
AU2007242758B2 (en) 2012-04-05
AU2007242758A1 (en) 2007-11-01
EP2013587B1 (en) 2018-04-04
RU2431805C2 (en) 2011-10-20
BRPI0710915A2 (en) 2011-09-27
CN101427107A (en) 2009-05-06
CN101427107B (en) 2011-08-31
US20090096467A1 (en) 2009-04-16

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