CA2679143A1 - Method and apparatus for measurement and control of temperature for infused liquids - Google Patents

Method and apparatus for measurement and control of temperature for infused liquids Download PDF

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Publication number
CA2679143A1
CA2679143A1 CA002679143A CA2679143A CA2679143A1 CA 2679143 A1 CA2679143 A1 CA 2679143A1 CA 002679143 A CA002679143 A CA 002679143A CA 2679143 A CA2679143 A CA 2679143A CA 2679143 A1 CA2679143 A1 CA 2679143A1
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Canada
Prior art keywords
temperature
fitting
fluid
medical fluid
sensing device
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Granted
Application number
CA002679143A
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French (fr)
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CA2679143C (en
Inventor
Durward I. Faries, Jr.
Bruce R. Heymann
Calvin Blankenship
David Hendrix
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Medical Solutions Inc
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Medical Solutions, Inc.
Durward I. Faries, Jr.
Bruce R. Heymann
Calvin Blankenship
David Hendrix
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Publication of CA2679143A1 publication Critical patent/CA2679143A1/en
Application granted granted Critical
Publication of CA2679143C publication Critical patent/CA2679143C/en
Active legal-status Critical Current
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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01KMEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K1/00Details of thermometers not specially adapted for particular types of thermometer
    • G01K1/14Supports; Fastening devices; Arrangements for mounting thermometers in particular locations
    • G01K1/146Supports; Fastening devices; Arrangements for mounting thermometers in particular locations arrangements for moving thermometers to or from a measuring position
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A61M5/445Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media the media being heated in the reservoir, e.g. warming bloodbags
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01KMEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K13/00Thermometers specially adapted for specific purposes
    • G01K13/02Thermometers specially adapted for specific purposes for measuring temperature of moving fluids or granular materials capable of flow
    • G01K13/026Thermometers specially adapted for specific purposes for measuring temperature of moving fluids or granular materials capable of flow of moving liquids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3368Temperature

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  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)
  • Measuring Temperature Or Quantity Of Heat (AREA)

Abstract

A device according to present invention embodiments measures the temperature of fluid within an IV line at selected locations. The device may be in the form of a fitting including a projection in fluid communication with a fluid channel to receive a temperature sensor. A thermally conductive receptacle may be disposed in the projection to receive the temperature sensor and partially extends into the fluid channel for contact with the fluid. The temperature sensor may be coupled to a temperature display device and/or controller to display the measured temperature and/or control a thermal element to regulate fluid temperature. The fitting may further include a looped configuration and/or a control valve that controls the flow of fluid through the fluid channel. In addition, the device may further be connected to, or be in the form of, a needle hub to measure fluid temperature proximate the entry site on a patient.

Claims (83)

1. A temperature sensing device for measuring temperature of a sterile medical fluid within a fluid line comprising:
a fitting securable to said fluid line and including:
a first open end and a second open end, each end being securable to selected portions of said fluid line;
a passage disposed within said fitting to permit said sterile medical fluid flowing within said fluid line to flow through said fitting;
a connection port in fluid communication with said passage to receive a temperature sensor for measuring temperature of said medical fluid;
wherein said fitting further includes at least one of a looped configuration to direct said medical fluid in a flow path about said temperature sensor, a needle hub assembly to direct said medical fluid into a patient and a flow controller to selectively control flow of said medical fluid through said fitting.
2. The temperature sensing device of claim 1 further including:
a thermally conductive receptacle secured within said connection port and extending partially within said passage to enable a distal end of said receptacle to contact said medical fluid flowing within said passage;
wherein said temperature sensor is removably received within said receptacle to measure temperature of said medical fluid flowing through said fitting.
3. The temperature sensing device of claim 2, wherein said connection port extends from an outer surface of said fitting, and said temperature sensing device further includes:

a securing member to secure said temperature sensor to said connection port, wherein said securing member includes a recess defined therein and said temperature sensor is disposed within said recess and extends to contact said receptacle when said securing member is secured to said connection port.
4. The temperature sensing device of claim 3, wherein said securing member and said connection port include a locking mechanism to releasably secure said securing member to said connection port and to facilitate contact between said temperature sensor and said receptacle.
5. The temperature sensing device of claim 4, wherein said locking mechanism includes:
at least one projection removably attached to an outer surface of said connection port; and at least one engagement member disposed on said securing member to engage a corresponding projection;
wherein said at least one engagement member is configured to remove said corresponding projection from said connection port in response to disengagement of said securing member with said engagement port to thereby prevent re-engagement of said connection port with said securing member and re-use of said fitting.
6. The temperature sensing device of claim 1, wherein said fitting includes said flow controller.
7. The temperature sensing device of claim 6, wherein said flow controller includes a locking mechanism to maintain said flow controller in a state enabling flow of said medical fluid through said fitting.
8. The temperature sensing device of claim 7, wherein said flow controller includes a housing and a piston slidably disposed therein, wherein said piston includes an aperture and is selectively manipulated linearly to align said aperture with said passage to control flow of said medical fluid within said fitting.
9. The temperature sensing device of claim 8, wherein said locking mechanism includes a projection disposed on a distal portion of said piston and a recess defined within a distal portion of said housing to engage said projection in response to said piston being urged distally within said housing.
10. The temperature sensing device of claim 7, wherein said flow controller includes a housing and a valve member rotatably disposed therein, wherein said valve member includes an aperture and is selectively rotated to align said aperture with said passage to control flow of said medical fluid within said fitting.
11. The temperature sensing device of claim 10, wherein said flow controller includes a rotatable gripping member to rotate said valve member, and said locking mechanism includes:
a plurality of grooves defined within a distal surface of said gripping member, wherein each said groove includes first and second ends and a shoulder disposed between those ends; and a plurality of projections extending from a proximal portion of said housing;
wherein said projections are received within corresponding grooves and traverse those grooves in response to rotation of said gripping member to enable said projections to be maintained within said grooves between a corresponding groove shoulder and groove end and prevent further rotation of said gripping member.
12. The temperature sensing device of claim 6, wherein said flow controller is controlled by a controller based on said measured fluid temperature.
13. The temperature sensing device of claim 1, wherein said fitting includes said looped configuration with at least one winding to direct said medical fluid about said temperature sensor.
14. The temperature sensing device of claim 1, wherein said fitting includes said needle hub assembly.
15. The temperature sensing device of claim 14, wherein said fitting and needle hub assembly are formed as an integral unit.
16. The temperature sensing device of claim 14, wherein said fitting is in the form of a valve.
17. The temperature sensing device of claim 1 further including a display to display said measured fluid temperature.
18. A method of measuring temperature of a sterile medical fluid flowing within a medical fluid line via a temperature sensing device including a fitting and a temperature sensor to measure temperature of fluid flowing through said fitting, wherein said fitting includes first and second open ends, a passage disposed within said fitting and extending between said first and second open ends to permit fluid flowing within said fluid line to flow through said fitting and a connection port in fluid communication with said passage, and wherein said fitting further includes at least one of a looped configuration, a needle hub assembly and a flow controller, said method comprising:
(a) securing said first and second ends of said fitting to selected portions of said fluid line;
(b) measuring a temperature of fluid flowing through said fitting via said temperature sensor disposed within said connection port and generating a temperature signal indicating said measured fluid temperature;
(c) in accordance with said fitting including said looped configuration, directing said medical fluid through said looped configuration and in a flow path about said temperature sensor to measure said fluid temperature;
(d) in accordance with said fitting including said flow controller, selectively controlling flow of said medical fluid through said fitting via said flow controller; and (e) in accordance with said fitting including said needle hub assembly, directing said medical fluid from said passage into a patient via said needle hub assembly.
19. The method of claim 18, wherein said fitting further includes a receptacle disposed within said connection port and in direct contact with fluid flowing within said passage, and step (b) further includes:
(b.1) inserting said temperature sensor within said connection port to contact said receptacle; and (b.2) measuring the temperature of said receptacle to indirectly determine the temperature of fluid flowing within said fitting.
20. The method of claim 19, wherein said connection port extends from an outer surface of said fitting and said temperature sensing device further includes a securing member to secure said temperature sensor to said connection port, wherein said securing member includes a recess defined therein and said temperature sensor is disposed within said recess, and step (b.1) further includes:
(b.1.1) securing said temperature sensor to said connection port via said securing member, wherein said temperature sensor is positioned in contact with said receptacle.
21. The method of claim 20, wherein said securing member and said connection port include a locking mechanism to releasably secure said securing member to said connection port, and step (b.1.1) further includes:
(b.1.1.1) locking said securing member to said connection port by disposing said connection port within said recess to enable said temperature sensor to contact said receptacle.
22. The method of claim 18, wherein said fitting includes said flow controller.
23. The method of claim 22, wherein said flow controller includes a housing and a piston slidably disposed therein, wherein said piston includes an aperture and step (d) further includes:

(d.1) selectively manipulating said piston linearly to align said aperture with said passage to control flow of said medical fluid within said fitting.
24. The method of claim 23, wherein said flow controller includes a locking mechanism, and step (d) further includes:
(d.2) maintaining said flow controller in a state enabling flow of said medical fluid through said fitting.
25. The method of claim 24, wherein said locking mechanism includes a projection disposed on a distal portion of said piston and a recess defined within a distal portion of said housing, and step (d.2) further includes:
(d.2.1) engaging said projection with said recess in response to said piston being urged distally within said housing.
26. The method of claim 22, wherein said flow controller includes a housing and a valve member rotatably disposed therein, wherein said valve member includes an aperture and step (d) further includes:
(d.1) selectively rotating said valve member to align said aperture with said passage to control flow of said medical fluid within said fitting.
27. The method of claim 26, wherein said flow controller includes a locking mechanism, and step (d) further includes:
(d.2) maintaining said flow controller in a state enabling flow of said medical fluid through said fitting.
28. The method of claim 27, wherein said flow controller includes a rotatable gripping member to rotate said valve member, and said locking mechanism includes a plurality of grooves defined within a distal surface of said gripping member, wherein each said groove includes first and second ends and a shoulder disposed between those ends, and a plurality of projections extending from a proximal portion of said housing, and wherein step (d.2) further includes:
(d.2.1) receiving said projections within corresponding grooves and traversing those grooves with said projections in response to rotation of said gripping member and maintaining said projections within said grooves between a corresponding groove shoulder and groove end to prevent further rotation of said gripping member.
29. The method of claim 22, wherein step (d) further includes:
(d.1) controlling said flow controller based on said measured fluid temperature.
30. The method of claim 18, wherein said fitting includes said looped configuration.
31. The method of claim 18, wherein said fitting includes said needle hub assembly.
32. The method of claim 31, wherein said fitting and needle hub assembly are formed as an integral unit.
33. The method of claim 31, wherein said fitting is in the form of a valve.
34. The method of claim 18, wherein step (b) further includes:
(b.1) displaying said measured fluid temperature.
35. A temperature sensing device for measuring temperature of a sterile medical fluid comprising:
a medical fluid container to house a sterile medical fluid;
a fluid line coupled to said medical fluid container to receive said sterile medical fluid therefrom and direct said medical fluid toward a patient;
at least one thermal treatment device securable to at least one of said medical fluid container and said fluid line and operable to thermally treat said sterile medical fluid;
a fitting disposed at a selected location along said fluid line and including:
a first open end and a second open end, each end being securable to selected portions of said fluid line;

a passage disposed within said fitting to permit said sterile medical fluid flowing within said fluid line to flow through said fitting; and a connection port in fluid communication with said passage;
a temperature sensor for placement within said connection port to measure temperature of said sterile medical fluid flowing through said fitting and to generate an electrical temperature signal indicating said measured fluid temperature; and a controller coupled to said temperature sensor and said at least one thermal treatment device to control said at least one thermal treatment device to thermally treat said medical fluid to a desired temperature based on said measured fluid temperature.
36. The temperature sensing device of claim 35, wherein said desired temperature is entered by a user.
37. The temperature sensing device of claim 35, wherein said thermal treatment device thermally treats said medical fluid in the form of at least one of heating and cooling.
38. The temperature sensing device of claim 35, wherein said controller displays said measured fluid temperature.
39. The temperature sensing device of claim 35 further including:
a thermally conductive receptacle secured within said connection port and extending partially within said passage to enable a distal end of said receptacle to contact said medical fluid flowing within said passage;
wherein said temperature sensor is removably received within said receptacle to measure temperature of said medical fluid flowing through said fitting.
40. The temperature sensing device of claim 39, wherein said connection port extends from an outer surface of said fitting, and said temperature sensing device further includes:

a securing member to secure said temperature sensor to said connection port, wherein said securing member includes a recess defined therein and said temperature sensor is disposed within said recess and extends to contact said receptacle when said securing member is secured to said connection port.
41. The temperature sensing device of claim 40, wherein said securing member and said connection port include a locking mechanism to releasably secure said securing member to said connection port and to facilitate contact between said temperature sensor and said receptacle.
42. The temperature sensing device of claim 35, wherein said fitting further includes a flow controller to selectively control flow of said medical fluid through said fitting.
43. The temperature sensing device of claim 42, wherein said flow controller includes a locking mechanism to maintain said flow controller in a state enabling flow of said medical fluid through said fitting.
44. The temperature sensing device of claim 42, wherein said flow controller includes a housing and a piston slidably disposed therein, wherein said piston includes an aperture and is selectively manipulated linearly to align said aperture with said passage to control flow of said medical fluid within said fitting.
45. The temperature sensing device of claim 42, wherein said flow controller includes a housing and a valve member rotatably disposed therein, wherein said valve member includes an aperture and is selectively rotated to align said aperture with said passage to control flow of said medical fluid within said fitting.
46. The temperature sensing device of claim 42, wherein said controller is coupled to said flow controller and manipulates said flow controller to control flow of said medical fluid based on said measured fluid temperature.
47. The temperature sensing device of claim 35, wherein said fitting includes a looped configuration to direct said medical fluid in a flow path about said temperature sensor.
48. The temperature sensing device of claim 35, further including a needle hub assembly coupled to said fitting to direct said medical fluid into a patient.
49. The temperature sensing device of claim 35, wherein said controller records said measured fluid temperature to generate a report.
50. The temperature sensing device of claim 49, further including a printer to print at least one of said measured fluid temperature and said report.
51. The temperature sensing device of claim 49, wherein said controller includes a communication module to transmit said report to another device.
52. A method of measuring temperature of a sterile medical fluid flowing within a medical fluid line via a temperature sensing device including a fitting and a temperature sensor to measure temperature of fluid flowing through said fitting, wherein said fitting includes first and second open ends, a passage disposed within said fitting and extending between said first and second open ends to permit fluid flowing within said fluid line to flow through said fitting and a connection port in fluid communication with said passage, said method comprising:

(a) securing said first and second ends of said fitting to selected portions of said fluid line;

(b) measuring a temperature of fluid flowing through said fitting via said temperature sensor disposed within said connection port and generating a temperature signal indicating said measured fluid temperature; and (c) controlling, via a controller, at least one thermal treatment device disposed proximate at least one of said fluid line and a fluid source to thermally treat said medical fluid to a desired temperature based on said measured fluid temperature.
53. The method of claim 52, wherein step (c) further includes:
(c.1) facilitating entry of said desired temperature into said controller by a user.
54. The method of claim 52 wherein each thermal treatment device thermally treats said medical fluid in the form of at least one of heating and cooling.
55. The method of claim 52, wherein step (b) further includes:
(b.1) displaying said measured fluid temperature.
56. The method of claim 52, wherein said fitting further includes a receptacle disposed within said connection port and in direct contact with fluid flowing within said passage, and step (b) further includes:
(b.1) inserting said temperature sensor within said connection port to contact said receptacle; and (b.2) measuring the temperature of said receptacle to indirectly determine the temperature of fluid flowing within said fitting.
57. The method of claim 52, wherein said fitting further includes a flow controller, and step (b) further includes:
(b.1) selectively controlling flow of said medical fluid through said fitting.
58. The method of claim 57, wherein step (c) further includes:
(c.1) controlling said flow controller based on said measured fluid temperature.
59. The method of claim 52, wherein said fitting includes a looped configuration, and step (b) further includes:
(b.1) directing said medical fluid in a flow path about said temperature sensor.
60. The method of claim 52, wherein said fitting includes a needle hub assembly coupled to said fitting, and step (c) further includes:
(c.1) directing said medical fluid into a patient.
61. The method of claim 52, further including:
(d) recording, via said controller, said measured fluid temperature to generate a report.
62. The method of claim 61, further including:
(e) printing at least one of said measured fluid temperature and said report via a printer.
63. The method of claim 61, further including:
(e) transmitting said report to another device via a communication module.
64. A temperature sensing device for measuring temperature of a sterile medical fluid within a fluid line comprising:
a fitting securable to said fluid line and including:
a first open end and a second open end, each end being securable to selected portions of said fluid line;

a passage disposed within said fitting to permit said sterile medical fluid flowing within said fluid line to flow through said fitting;
a connection port in fluid communication with said passage; and a thermally conductive receptacle secured within said connection port and partially extending within said passage a maximum of one half of the passage transverse dimension to enable a distal end of said receptacle to contact said medical fluid flowing within said passage, wherein said receptacle receives a temperature sensor for measuring temperature of said medical fluid.
65. The temperature sensing device of claim 64, wherein said receptacle partially extends within said passage a maximum of one quarter of the passage transverse dimension.
66. A method of measuring temperature of a sterile medical fluid flowing within a medical fluid line via a temperature sensing device including a fitting and a temperature sensor to measure temperature of fluid flowing through said fitting, wherein said fitting includes first and second open ends, a passage disposed within said fitting and extending between said first and second open ends to permit fluid flowing within said fluid line to flow through said fitting, a connection port in fluid communication with said passage and a receptacle disposed within said connection port and in direct contact with fluid flowing within said passage, said method comprising:
(a) securing said first and second ends of said fitting to selected portions of said fluid line;

(b) inserting said temperature sensor within said connection port to contact said receptacle, wherein said receptacle partially extends within said passage a maximum of one half of the passage transverse dimension to enable a distal end of said receptacle to contact said medical fluid flowing within said passage; and (c) measuring temperature of fluid flowing through said fitting by measuring the temperature of said receptacle and generating a temperature signal indicating said measured fluid temperature.
67. The method of claim 66, wherein said receptacle partially extends within said passage a maximum of one quarter of the passage transverse dimension.
68. A temperature sensing device for measuring temperature of a sterile medical fluid comprising:

a medical fluid container to house a sterile medical fluid;

a fluid line coupled to said medical fluid container to receive said sterile medical fluid therefrom and direct said medical fluid toward a patient;

at least one thermal treatment device securable to at least one of said medical fluid container and said fluid line and operable to thermally treat said sterile medical fluid;

a sensing assembly securable to selected locations along said fluid line and including:
a passage disposed within said sensing assembly to permit said sterile medical fluid flowing within said fluid line to flow through said sensing assembly;
and a temperature sensor to measure temperature of said sterile medical fluid flowing through said passage and to generate an electrical temperature signal indicating said measured fluid temperature; and a controller coupled to said temperature sensor and said at least one thermal treatment device to control said at least one thermal treatment device to thermally treat said medical fluid to a desired temperature based on said measured fluid temperature.
69. The temperature sensing device of claim 68, wherein said desired temperature is entered by a user.
70. The temperature sensing device of claim 68, wherein said thermal treatment device thermally treats said medical fluid in the form of at least one of heating and cooling.
71. The temperature sensing device of claim 68, wherein said controller displays said measured fluid temperature.
72. The temperature sensing device of claim 68, wherein said sensing assembly further includes a flow controller to selectively control flow of said medical fluid through said passage.
73. The temperature sensing device of claim 72, wherein said controller is coupled to said flow controller and manipulates said flow controller to control flow of said medical fluid based on said measured fluid temperature.
74. The temperature sensing device of claim 68, wherein said sensing assembly includes a fitting with a looped configuration to direct said medical fluid in a flow path about said temperature sensor.
75. The temperature sensing device of claim 68, further including a needle hub assembly coupled to said sensing assembly to direct said medical fluid into a patient.
76. A method of measuring temperature of a sterile medical fluid flowing within a medical fluid line via a temperature sensing device including a sensing assembly with a temperature sensor to measure temperature of fluid flowing through said sensing assembly, wherein said sensing assembly further includes a passage disposed within said sensing assembly to permit fluid flowing within said fluid line to flow through said passage, said method comprising:

(a) receiving said sensing assembly at selected portions of said fluid line;
(b) measuring a temperature of fluid flowing through said passage via said temperature sensor and generating a temperature signal indicating said measured fluid temperature; and (c) controlling, via a controller, at least one thermal treatment device disposed proximate at least one of said fluid line and a fluid source to thermally treat said medical fluid to a desired temperature based on said measured fluid temperature.
77. The method of claim 76, wherein step (c) further includes:

(c.1) facilitating entry of said desired temperature into said controller by a user.
78. The method of claim 76, wherein each thermal treatment device thermally treats said medical fluid in the form of at least one of heating and cooling.
79. The method of claim 76, wherein step (b) further includes:
(b.1) displaying said measured fluid temperature.
80. The method of claim 76, wherein said sensing assembly further includes a flow controller, and step (b) further includes:

(b.1) selectively controlling flow of said medical fluid through said sensing assembly.
81. The method of claim 80, wherein step (c) further includes:

(c.1) controlling said flow controller based on said measured fluid temperature.
82. The method of claim 76, wherein said sensing assembly includes a fitting with a looped configuration, and step (b) further includes:

(b.l) directing said medical fluid in a flow path about said temperature sensor.
83. The method of claim 76, wherein said temperature sensing device includes a needle hub assembly coupled to said sensing assembly, and step (c) further includes:

(c.1) directing said medical fluid into a patient.
CA2679143A 2007-02-22 2008-02-21 Method and apparatus for measurement and control of temperature for infused liquids Active CA2679143C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/677,673 2007-02-22
US11/677,673 US8226293B2 (en) 2007-02-22 2007-02-22 Method and apparatus for measurement and control of temperature for infused liquids
PCT/US2008/054551 WO2008103809A2 (en) 2007-02-22 2008-02-21 Method and apparatus for measurement and control of temperature for infused liquids

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CA2679143A1 true CA2679143A1 (en) 2008-08-28
CA2679143C CA2679143C (en) 2012-12-04

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US (1) US8226293B2 (en)
EP (1) EP2117487A2 (en)
JP (2) JP2010518986A (en)
AU (1) AU2008218324B2 (en)
CA (1) CA2679143C (en)
WO (1) WO2008103809A2 (en)

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