CA2721172A1 - Microfabricated elastomeric valve and pump systems - Google Patents
Microfabricated elastomeric valve and pump systems Download PDFInfo
- Publication number
- CA2721172A1 CA2721172A1 CA 2721172 CA2721172A CA2721172A1 CA 2721172 A1 CA2721172 A1 CA 2721172A1 CA 2721172 CA2721172 CA 2721172 CA 2721172 A CA2721172 A CA 2721172A CA 2721172 A1 CA2721172 A1 CA 2721172A1
- Authority
- CA
- Canada
- Prior art keywords
- microfabricated
- channel
- elastomeric structure
- elastomeric
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012528 membrane Substances 0.000 claims 17
- -1 poly(styrene-butadiene-styrene) Polymers 0.000 claims 10
- 239000000463 material Substances 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims 2
- 229920002449 FKM Polymers 0.000 claims 1
- 229920004459 Kel-F® PCTFE Polymers 0.000 claims 1
- 229920000459 Nitrile rubber Polymers 0.000 claims 1
- 239000005062 Polybutadiene Substances 0.000 claims 1
- 229920002367 Polyisobutene Polymers 0.000 claims 1
- 229920003237 carborane-containing polymer Polymers 0.000 claims 1
- UUAGAQFQZIEFAH-UHFFFAOYSA-N chlorotrifluoroethylene Chemical compound FC(F)=C(F)Cl UUAGAQFQZIEFAH-UHFFFAOYSA-N 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 claims 1
- 239000000806 elastomer Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- GKTNLYAAZKKMTQ-UHFFFAOYSA-N n-[bis(dimethylamino)phosphinimyl]-n-methylmethanamine Chemical compound CN(C)P(=N)(N(C)C)N(C)C GKTNLYAAZKKMTQ-UHFFFAOYSA-N 0.000 claims 1
- 229920001084 poly(chloroprene) Polymers 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920002857 polybutadiene Polymers 0.000 claims 1
- 229920001748 polybutylene Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 229920001195 polyisoprene Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C51/00—Shaping by thermoforming, i.e. shaping sheets or sheet like preforms after heating, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B5/00—Devices comprising elements which are movable in relation to each other, e.g. comprising slidable or rotatable elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
- B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
- F15C1/00—Circuit elements having no moving parts
- F15C1/02—Details, e.g. special constructional devices for circuits with fluid elements, such as resistances, capacitive circuit elements; devices preventing reaction coupling in composite elements ; Switch boards; Programme devices
- F15C1/06—Constructional details; Selection of specified materials ; Constructional realisation of one single element; Canal shapes; Jet nozzles; Assembling an element with other devices, only if the element forms the main part
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
- F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K1/00—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces
- F16K1/16—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members
- F16K1/18—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps
- F16K1/20—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps with axis of rotation arranged externally of valve member
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
- F16K11/10—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit
- F16K11/20—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit operated by separate actuating members
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K13/00—Other constructional types of cut-off apparatus; Arrangements for cutting-off
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K31/00—Actuating devices; Operating means; Releasing devices
- F16K31/12—Actuating devices; Operating means; Releasing devices actuated by fluid
- F16K31/126—Actuating devices; Operating means; Releasing devices actuated by fluid the fluid acting on a diaphragm, bellows, or the like
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0015—Diaphragm or membrane valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
- F16K99/0046—Electric operating means therefor using magnets
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
- F16K99/0048—Electric operating means therefor using piezoelectric means
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0042—Electric operating means therefor
- F16K99/0051—Electric operating means therefor using electrostatic means
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
- F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
- F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/046—Chemical or electrochemical formation of bubbles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/03—Microengines and actuators
- B81B2201/036—Micropumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/05—Microfluidics
- B81B2201/054—Microvalves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C2201/00—Manufacture or treatment of microstructural devices or systems
- B81C2201/01—Manufacture or treatment of microstructural devices or systems in or on a substrate
- B81C2201/0174—Manufacture or treatment of microstructural devices or systems in or on a substrate for making multi-layered devices, film deposition or growing
- B81C2201/019—Bonding or gluing multiple substrate layers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C2201/00—Manufacture or treatment of microstructural devices or systems
- B81C2201/03—Processes for manufacturing substrate-free structures
- B81C2201/034—Moulding
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/0078—Fabrication methods specifically adapted for microvalves using moulding or stamping
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0073—Fabrication methods specifically adapted for microvalves
- F16K2099/008—Multi-layer fabrications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K2099/0082—Microvalves adapted for a particular use
- F16K2099/0094—Micropumps
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
- Y10T137/0402—Cleaning, repairing, or assembling
- Y10T137/0491—Valve or valve element assembling, disassembling, or replacing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
- Y10T137/0402—Cleaning, repairing, or assembling
- Y10T137/0491—Valve or valve element assembling, disassembling, or replacing
- Y10T137/0497—Fluid actuated or retarded
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
- Y10T137/2224—Structure of body of device
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87249—Multiple inlet with multiple outlet
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/8593—Systems
- Y10T137/87917—Flow path with serial valves and/or closures
- Y10T137/87981—Common actuator
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24744—Longitudinal or transverse tubular cavity or cell
Abstract
A microfabricated elastomeric structure comprises an elastomeric block formed with microfabricated recesses having a width less than 1000 µm therein. A portion of the elastomeric block is deflectable into one of the recesses when the portion is actuated.
Claims (23)
1. A microfabricated elastomeric structure, comprising:
an elastomeric block formed with microfabricated recesses having a width less than 1000 µm therein, a portion of the elastomeric block is deflectable into one of the recesses when the portion is actuated.
an elastomeric block formed with microfabricated recesses having a width less than 1000 µm therein, a portion of the elastomeric block is deflectable into one of the recesses when the portion is actuated.
2. A microfabricated elastomeric structure of claim 1 wherein;
the recesses comprise a first microfabricated channel and a first microfabricated recess; and the portion comprises an elastomeric membrane deflectable into the first microfabricated channel when the membrane is actuated.
the recesses comprise a first microfabricated channel and a first microfabricated recess; and the portion comprises an elastomeric membrane deflectable into the first microfabricated channel when the membrane is actuated.
3. A microfabricated elastomeric structure of claim 2 wherein the first microfabricated recess comprises a second microfabricated channel.
4. The microfabricated elastomeric structure of claim 3, wherein the first and second microfabricated channels cross over one another, but do not intersect.
5. The microfabricated elastomeric structure of claim 2 wherein the membrane is deflectable into the first channel when the first microfabricated recess is pressurized.
6. The microfabricated elastomeric structure of claim 2 wherein the membrane is deflectable into the first channel when the membrane is electrostatically actuated.
7. The microfabricated elastomeric structure of claim 6 wherein:
a first conductive portion is provided in the membrane; and a second conductive portion is disposed on an opposite side of the first channel from the first conductive portion.
a first conductive portion is provided in the membrane; and a second conductive portion is disposed on an opposite side of the first channel from the first conductive portion.
8. The microfabricated elastomeric structure of claim 3 wherein the first and second microfabricated channels both pass through the elastomeric structure.
9. The microfabricated elastomeric structure of claim 3 wherein the second microfabricated channel passes through the elastomeric structure and the first microfabricated channel passes along a surface of the elastomeric structure.
10. The microfabricated elastomeric structure of claim 9, further comprising:
a planar substrate positioned adjacent the surface of the elastomeric structure along which the first microfabricated channel passes.
a planar substrate positioned adjacent the surface of the elastomeric structure along which the first microfabricated channel passes.
11. The microfabricated elastomeric structure of claim 3 further comprising a third microfabricated channel parallel to the first channel, the second channel having both wide and narrow portions disposed along its length, with a wide portion being disposed adjacent the first channel and a narrow portion being disposed adjacent the third channel.
12. The microfabricated elastomeric structure of claim 11, wherein pressurizing the second channel causes the membrane separating the second channel from the first channel to be deflected into the first channel but does not cause the membrane separating the third channel from the second channel to be deflected into the third channel.
13. A microfabricated elastomeric structure of claim 3 wherein;
the first microfabricated channel is T-shaped and includes a stem in fluid communication with a first branch and a second branch;
the elastomeric membrane overlies and is deflectable into the first branch;
and the elastomeric structure further comprises a second recess overlying the second branch such that a second elastomeric membrane is deflectable into the second branch when the membrane is actuated, such that a flow of fluid into the stem may be directed into one of the first branch and the second branch by actuating the second elastomeric membrane and the first elastomeric membrane, respectively.
the first microfabricated channel is T-shaped and includes a stem in fluid communication with a first branch and a second branch;
the elastomeric membrane overlies and is deflectable into the first branch;
and the elastomeric structure further comprises a second recess overlying the second branch such that a second elastomeric membrane is deflectable into the second branch when the membrane is actuated, such that a flow of fluid into the stem may be directed into one of the first branch and the second branch by actuating the second elastomeric membrane and the first elastomeric membrane, respectively.
14. The microfabricated elastomeric structure of claim 3, further comprising:
third and fourth channels disposed parallel to the second channel, wherein the second, third and fourth channels are separated from the first channel by first, second and third membranes respectively, deflectable into the first channel.
third and fourth channels disposed parallel to the second channel, wherein the second, third and fourth channels are separated from the first channel by first, second and third membranes respectively, deflectable into the first channel.
15. The microfabricated elastomeric structure of claim 14, wherein the first, second, and third membranes are deflectable into the first channel when the second, third and fourth channels, respectively, are pressurized.
16. The microfabricated elastomeric structure of claim 14 wherein the first, second, and third membranes are deflectable into the first channel when the membranes are electrostatically actuated.
17. The microfabricated elastomeric structure of claim 1 wherein the elastomeric structure comprises a material selected from the group consisting of.
polyisoprene, polybutadiene, polychloroprene, polyisobutylene, poly(styrene-butadiene-styrene), the polyurethanes, and silicones.
polyisoprene, polybutadiene, polychloroprene, polyisobutylene, poly(styrene-butadiene-styrene), the polyurethanes, and silicones.
18. The microfabricated elastomeric structure of claim 1 wherein the elastomeric structure comprises a material selected from the group consisting of:
poly(bis(fluoroalkoxy)phosphazene) (PNF, Eypel-F), poly(carboranesiloxanes) (Dexsil), poly(acrylonitrile-butadiene) (nitrile rubber), poly(1-butene), poly(chlorotrifluoroethylene-vinylidene fluoride) copolymers (Kel-F), poly(ethyl vinyl ether), poly(vinylidene fluoride), poly(vinylidene fluoride-hexafluoropropylene) copolymer (Viton).
poly(bis(fluoroalkoxy)phosphazene) (PNF, Eypel-F), poly(carboranesiloxanes) (Dexsil), poly(acrylonitrile-butadiene) (nitrile rubber), poly(1-butene), poly(chlorotrifluoroethylene-vinylidene fluoride) copolymers (Kel-F), poly(ethyl vinyl ether), poly(vinylidene fluoride), poly(vinylidene fluoride-hexafluoropropylene) copolymer (Viton).
19. The microfabricated elastomeric structure of claim 1 wherein the elastomeric structure comprises a material selected from the group consisting of:
elastomer compositions of polyvinylchloride (PVC), polysulfone, polycarbonate, polymethylmethacrylate (PMMA), or polytetrafluoroethylene (Teflon).
elastomer compositions of polyvinylchloride (PVC), polysulfone, polycarbonate, polymethylmethacrylate (PMMA), or polytetrafluoroethylene (Teflon).
20. A microfabricated elastomeric structure comprising:
an elastomeric block;
a first channel and a second channel separated by a separating portion of the elastomeric structure; and a microfabricated recess in the elastomeric block adjacent to the separating portion such that the separating portion may be actuated to deflect into the microfabricated recess.
an elastomeric block;
a first channel and a second channel separated by a separating portion of the elastomeric structure; and a microfabricated recess in the elastomeric block adjacent to the separating portion such that the separating portion may be actuated to deflect into the microfabricated recess.
21. The microfabricated elastomeric structure of claim 20 wherein the microfabricated recess experiences a reduced pressure which causes the separating portion to deflect into the microfabricated recess.
22. The microfabricated elastomeric structure of claim 20 wherein the separating portion is deflectable into the microfabricated recess when the separating portion is electrostatically actuated.
23. The microfabricated elastomeric structure of claim 20 wherein the separating portion is deflectable into the first channel when the separating portion is magnetically actuated.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2767084A CA2767084C (en) | 1999-06-28 | 2000-06-27 | Microfabricated elastomeric valve and pump systems |
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14150399P | 1999-06-28 | 1999-06-28 | |
US60/141,503 | 1999-06-28 | ||
US14719999P | 1999-08-03 | 1999-08-03 | |
US60/147,199 | 1999-08-03 | ||
US18685600P | 2000-03-03 | 2000-03-03 | |
US60/186,856 | 2000-03-03 | ||
CA2378190A CA2378190C (en) | 1999-06-28 | 2000-06-27 | Microfabricated elastomeric valve and pump systems |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2378190A Division CA2378190C (en) | 1999-06-28 | 2000-06-27 | Microfabricated elastomeric valve and pump systems |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2767084A Division CA2767084C (en) | 1999-06-28 | 2000-06-27 | Microfabricated elastomeric valve and pump systems |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2721172A1 true CA2721172A1 (en) | 2001-01-04 |
CA2721172C CA2721172C (en) | 2012-04-10 |
Family
ID=27385668
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2378190A Expired - Lifetime CA2378190C (en) | 1999-06-28 | 2000-06-27 | Microfabricated elastomeric valve and pump systems |
CA 2721172 Expired - Lifetime CA2721172C (en) | 1999-06-28 | 2000-06-27 | Microfabricated elastomeric valve and pump systems |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2378190A Expired - Lifetime CA2378190C (en) | 1999-06-28 | 2000-06-27 | Microfabricated elastomeric valve and pump systems |
Country Status (18)
Country | Link |
---|---|
US (15) | US7601270B1 (en) |
EP (3) | EP2309130B1 (en) |
JP (5) | JP2003524738A (en) |
KR (1) | KR100865105B1 (en) |
CN (1) | CN100402850C (en) |
AT (3) | ATE343724T1 (en) |
AU (1) | AU779988B2 (en) |
BR (1) | BR0011982B1 (en) |
CA (2) | CA2378190C (en) |
DE (3) | DE60018425T2 (en) |
DK (1) | DK1065378T3 (en) |
ES (1) | ES2174798T3 (en) |
GB (1) | GB2352283A (en) |
IL (2) | IL147302A0 (en) |
MX (1) | MXPA01012959A (en) |
NO (1) | NO330662B1 (en) |
NZ (1) | NZ533466A (en) |
WO (1) | WO2001001025A2 (en) |
Families Citing this family (722)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US7052594B2 (en) | 2002-01-31 | 2006-05-30 | Sri International | Devices and methods for controlling fluid flow using elastic sheet deflection |
US6833242B2 (en) * | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
DE60025715T2 (en) | 1999-04-26 | 2006-07-27 | GMP Vision Solutions, Inc., Ft. Lauderdale | STENT DEVICE FOR GLUCKOM TREATMENT |
US6929030B2 (en) * | 1999-06-28 | 2005-08-16 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US8052792B2 (en) | 2001-04-06 | 2011-11-08 | California Institute Of Technology | Microfluidic protein crystallography techniques |
US8550119B2 (en) * | 1999-06-28 | 2013-10-08 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7459022B2 (en) * | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
US7052545B2 (en) * | 2001-04-06 | 2006-05-30 | California Institute Of Technology | High throughput screening of crystallization of materials |
US7144616B1 (en) * | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
EP2309130B1 (en) | 1999-06-28 | 2016-08-10 | California Institute of Technology | Microfabricated elastomeric valve and pump systems |
US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US7217321B2 (en) | 2001-04-06 | 2007-05-15 | California Institute Of Technology | Microfluidic protein crystallography techniques |
US6899137B2 (en) * | 1999-06-28 | 2005-05-31 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
US7195670B2 (en) * | 2000-06-27 | 2007-03-27 | California Institute Of Technology | High throughput screening of crystallization of materials |
US20080277007A1 (en) * | 1999-06-28 | 2008-11-13 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US6432290B1 (en) | 1999-11-26 | 2002-08-13 | The Governors Of The University Of Alberta | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
CA2290731A1 (en) | 1999-11-26 | 2001-05-26 | D. Jed Harrison | Apparatus and method for trapping bead based reagents within microfluidic analysis system |
IL151122A0 (en) * | 2000-02-23 | 2003-04-10 | Caliper Techn Corp | Multi-reservoir pressure control system |
US20020012926A1 (en) * | 2000-03-03 | 2002-01-31 | Mycometrix, Inc. | Combinatorial array for nucleic acid analysis |
US7867763B2 (en) * | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
US20050118073A1 (en) * | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
US6627159B1 (en) | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
US7236831B2 (en) * | 2000-07-13 | 2007-06-26 | Northstar Neuroscience, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
US6669669B2 (en) * | 2001-10-12 | 2003-12-30 | Insulet Corporation | Laminated patient infusion device |
AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
EP1322936A2 (en) * | 2000-10-03 | 2003-07-02 | California Institute Of Technology | Microfluidic devices and methods of use |
US7097809B2 (en) * | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
US6508988B1 (en) * | 2000-10-03 | 2003-01-21 | California Institute Of Technology | Combinatorial synthesis system |
EP1336097A4 (en) * | 2000-10-13 | 2006-02-01 | Fluidigm Corp | Microfluidic device based sample injection system for analytical devices |
WO2002065005A1 (en) | 2000-11-06 | 2002-08-22 | California Institute Of Technology | Electrostatic valves for microfluidic devices |
DE60103924T2 (en) * | 2000-11-06 | 2005-07-14 | Nanostream, Inc., Pasadena | MICROFLUID FLOW RATE DEVICE |
US8097471B2 (en) | 2000-11-10 | 2012-01-17 | 3M Innovative Properties Company | Sample processing devices |
US20020123112A1 (en) * | 2000-11-13 | 2002-09-05 | Genoptix | Methods for increasing detection sensitivity in optical dielectric sorting systems |
US20020160470A1 (en) * | 2000-11-13 | 2002-10-31 | Genoptix | Methods and apparatus for generating and utilizing linear moving optical gradients |
US6936811B2 (en) * | 2000-11-13 | 2005-08-30 | Genoptix, Inc. | Method for separating micro-particles |
US20030007894A1 (en) * | 2001-04-27 | 2003-01-09 | Genoptix | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
US20020121443A1 (en) * | 2000-11-13 | 2002-09-05 | Genoptix | Methods for the combined electrical and optical identification, characterization and/or sorting of particles |
US7378280B2 (en) | 2000-11-16 | 2008-05-27 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
AU2002248149A1 (en) * | 2000-11-16 | 2002-08-12 | Fluidigm Corporation | Microfluidic devices for introducing and dispensing fluids from microfluidic systems |
CA2364132C (en) * | 2000-12-12 | 2010-06-01 | Bayer Corporation | Method of making a capillary channel |
FR2817974B1 (en) * | 2000-12-12 | 2003-09-12 | Commissariat Energie Atomique | OPTICAL MICRO-ACTUATOR, OPTICAL COMPONENT USING THE MICRO-ACTUATOR, AND METHOD FOR PRODUCING AN OPTICAL MICRO-ACTUATOR |
JP4248238B2 (en) * | 2001-01-08 | 2009-04-02 | プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | Valves and pumps for microfluidic systems and methods for making microfluidic systems |
US20020098122A1 (en) * | 2001-01-22 | 2002-07-25 | Angad Singh | Active disposable microfluidic system with externally actuated micropump |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US6904784B2 (en) * | 2001-02-27 | 2005-06-14 | Teledyne Isco, Inc. | Liquid chromatographic method and system |
US20050196785A1 (en) * | 2001-03-05 | 2005-09-08 | California Institute Of Technology | Combinational array for nucleic acid analysis |
WO2002075312A1 (en) | 2001-03-19 | 2002-09-26 | Gyros Ab | Characterization of reaction variables |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
US6752922B2 (en) | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
EP1384022A4 (en) | 2001-04-06 | 2004-08-04 | California Inst Of Techn | Nucleic acid amplification utilizing microfluidic devices |
US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
US20020164816A1 (en) * | 2001-04-06 | 2002-11-07 | California Institute Of Technology | Microfluidic sample separation device |
ATE500051T1 (en) | 2001-04-06 | 2011-03-15 | Fluidigm Corp | POLYMER SURFACE MODIFICATION |
EP1679121A3 (en) * | 2001-04-06 | 2006-07-26 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
EP1661623A3 (en) * | 2001-04-06 | 2006-06-07 | Fluidigm Corporation | Microfluidic delivery system |
AU2002258754B2 (en) | 2001-04-07 | 2006-08-17 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
US20030194755A1 (en) * | 2001-04-27 | 2003-10-16 | Genoptix, Inc. | Early detection of apoptotic events and apoptosis using optophoretic analysis |
US20030124516A1 (en) * | 2001-04-27 | 2003-07-03 | Genoptix, Inc. | Method of using optical interrogation to determine a biological property of a cell or population of cells |
US20040023310A1 (en) * | 2001-04-27 | 2004-02-05 | Genoptix, Inc | Quantitative determination of protein kinase C activation using optophoretic analysis |
US20020186263A1 (en) * | 2001-06-07 | 2002-12-12 | Nanostream, Inc. | Microfluidic fraction collectors |
US6729352B2 (en) | 2001-06-07 | 2004-05-04 | Nanostream, Inc. | Microfluidic synthesis devices and methods |
US7318912B2 (en) * | 2001-06-07 | 2008-01-15 | Nanostream, Inc. | Microfluidic systems and methods for combining discrete fluid volumes |
GB0116384D0 (en) * | 2001-07-04 | 2001-08-29 | Diagnoswiss Sa | Microfluidic chemical assay apparatus and method |
KR100421359B1 (en) * | 2001-07-24 | 2004-03-06 | 엘지전자 주식회사 | Method for delivering fluid in elastic substrate and device for it |
US6734436B2 (en) | 2001-08-07 | 2004-05-11 | Sri International | Optical microfluidic devices and methods |
US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
US7075162B2 (en) | 2001-08-30 | 2006-07-11 | Fluidigm Corporation | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes |
SG106631A1 (en) * | 2001-08-31 | 2004-10-29 | Agency Science Tech & Res | Liquid delivering device |
DE20115733U1 (en) * | 2001-09-25 | 2001-12-20 | Festo Ag & Co | Valve device |
US20030073961A1 (en) * | 2001-09-28 | 2003-04-17 | Happ Dorrie M. | Medical device containing light-protected therapeutic agent and a method for fabricating thereof |
US20030108664A1 (en) * | 2001-10-05 | 2003-06-12 | Kodas Toivo T. | Methods and compositions for the formation of recessed electrical features on a substrate |
US8440093B1 (en) | 2001-10-26 | 2013-05-14 | Fuidigm Corporation | Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels |
WO2003037514A2 (en) * | 2001-10-30 | 2003-05-08 | The Texas A & M University System | Method and apparatus for temperature gradient microfluidics |
US20030087455A1 (en) * | 2001-11-07 | 2003-05-08 | Eggers Mitchell D | Sample carrier system |
GB0128350D0 (en) * | 2001-11-27 | 2002-01-16 | Lab901 Ltd | Non-rigid apparatus for microfluidic applications |
US7691333B2 (en) * | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
AU2002351187A1 (en) | 2001-11-30 | 2003-06-17 | Fluidigm Corporation | Microfluidic device and methods of using same |
AU2002351291A1 (en) | 2001-12-06 | 2003-06-23 | Nanostream, Inc. | Adhesiveless microfluidic device fabrication |
US6622746B2 (en) | 2001-12-12 | 2003-09-23 | Eastman Kodak Company | Microfluidic system for controlled fluid mixing and delivery |
US6739576B2 (en) | 2001-12-20 | 2004-05-25 | Nanostream, Inc. | Microfluidic flow control device with floating element |
GB2383546B (en) * | 2001-12-28 | 2006-03-01 | Norchip As | Fluid manipulation in a microfabricated reaction chamber system |
EP1458473A2 (en) * | 2001-12-28 | 2004-09-22 | Norchip A/S | Fluid manipulation in a microfabricated reaction chamber system |
US7289132B1 (en) * | 2003-12-19 | 2007-10-30 | Apple Inc. | Method and apparatus for image acquisition, organization, manipulation, and publication |
US6568799B1 (en) | 2002-01-23 | 2003-05-27 | Eastman Kodak Company | Drop-on-demand ink jet printer with controlled fluid flow to effect drop ejection |
US7524459B2 (en) * | 2002-01-24 | 2009-04-28 | California Institute Of Technology In Pasadena | Optoelectronic and microfluidic integration for miniaturized spectroscopic devices |
US6814859B2 (en) | 2002-02-13 | 2004-11-09 | Nanostream, Inc. | Frit material and bonding method for microfluidic separation devices |
US6561224B1 (en) * | 2002-02-14 | 2003-05-13 | Abbott Laboratories | Microfluidic valve and system therefor |
GB0204009D0 (en) * | 2002-02-20 | 2002-04-03 | Xaar Technology Ltd | Actuation device and use thereof in droplet deposition |
US20030180711A1 (en) * | 2002-02-21 | 2003-09-25 | Turner Stephen W. | Three dimensional microfluidic device having porous membrane |
US6958119B2 (en) * | 2002-02-26 | 2005-10-25 | Agilent Technologies, Inc. | Mobile phase gradient generation microfluidic device |
CN1646682A (en) * | 2002-02-27 | 2005-07-27 | 密执安大学评议会 | Process for sorting motile particles from lesser-motile particles and apparatus suitable therefor |
CA2480728A1 (en) | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US6637476B2 (en) | 2002-04-01 | 2003-10-28 | Protedyne Corporation | Robotically manipulable sample handling tool |
US6872645B2 (en) * | 2002-04-02 | 2005-03-29 | Nanosys, Inc. | Methods of positioning and/or orienting nanostructures |
US6877528B2 (en) * | 2002-04-17 | 2005-04-12 | Cytonome, Inc. | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
US9943847B2 (en) | 2002-04-17 | 2018-04-17 | Cytonome/St, Llc | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
US6808075B2 (en) | 2002-04-17 | 2004-10-26 | Cytonome, Inc. | Method and apparatus for sorting particles |
US6976590B2 (en) | 2002-06-24 | 2005-12-20 | Cytonome, Inc. | Method and apparatus for sorting particles |
US20030211461A1 (en) * | 2002-05-01 | 2003-11-13 | Genoptix, Inc | Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells |
US20040033539A1 (en) * | 2002-05-01 | 2004-02-19 | Genoptix, Inc | Method of using optical interrogation to determine a biological property of a cell or population of cells |
DE10220371A1 (en) * | 2002-05-07 | 2003-11-27 | Fraunhofer Ges Forschung | Free jet metering module and method for its production |
US20030208936A1 (en) * | 2002-05-09 | 2003-11-13 | Lee Charles Hee | Method for manufacturing embroidery decorated cards and envelopes |
US7059348B2 (en) * | 2002-05-13 | 2006-06-13 | Fluidigm Corporation | Drug delivery system |
US7125510B2 (en) * | 2002-05-15 | 2006-10-24 | Zhili Huang | Microstructure fabrication and microsystem integration |
US20030217923A1 (en) * | 2002-05-24 | 2003-11-27 | Harrison D. Jed | Apparatus and method for trapping bead based reagents within microfluidic analysis systems |
US7217426B1 (en) | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
US20060086309A1 (en) * | 2002-06-24 | 2006-04-27 | Fluiding Corporation | Recirculating fluidic network and methods for using the same |
US20040124085A1 (en) * | 2002-06-26 | 2004-07-01 | California Institute Of Technology | Microfluidic devices and methods with electrochemically actuated sample processing |
JP2006507921A (en) * | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | Method and apparatus for fluid dispersion |
US7201881B2 (en) * | 2002-07-26 | 2007-04-10 | Applera Corporation | Actuator for deformable valves in a microfluidic device, and method |
US7452509B2 (en) * | 2002-07-26 | 2008-11-18 | Applied Biosystems Inc. | Microfluidic device including displaceable material trap, and system |
US7135147B2 (en) * | 2002-07-26 | 2006-11-14 | Applera Corporation | Closing blade for deformable valve in a microfluidic device and method |
US7198759B2 (en) * | 2002-07-26 | 2007-04-03 | Applera Corporation | Microfluidic devices, methods, and systems |
DE10241294A1 (en) * | 2002-09-04 | 2004-03-18 | Basf Ag | Hybrid dispersion of polyaddition products and radical polymerisates obtainable by emulsification useful as a coating or impregnation binder or binder for adhesives, paints, paper coatings or as binder for nonwoven fibers |
US20060099135A1 (en) * | 2002-09-10 | 2006-05-11 | Yodh Arjun G | Carbon nanotubes: high solids dispersions and nematic gels thereof |
EP1403209A1 (en) * | 2002-09-24 | 2004-03-31 | The Technology Partnership Limited | Fluid routing device |
JP2006501056A (en) | 2002-09-25 | 2006-01-12 | カリフォルニア インスティテュート オブ テクノロジー | Micro fluid large scale integration |
US8220494B2 (en) | 2002-09-25 | 2012-07-17 | California Institute Of Technology | Microfluidic large scale integration |
TW590982B (en) * | 2002-09-27 | 2004-06-11 | Agnitio Science & Technology I | Micro-fluid driving device |
AU2003271657A1 (en) * | 2002-09-30 | 2004-04-23 | Siemens Aktiengesellschaft | Substrate with a planar surface section, method for the production of a material film on the surface section of the substrate and use of said substrate |
EP1546412B1 (en) | 2002-10-02 | 2014-05-21 | California Institute Of Technology | Microfluidic nucleic acid analysis |
GB0224121D0 (en) * | 2002-10-16 | 2002-11-27 | Microemissive Displays Ltd | Method of patterning a functional material on to a substrate |
DE10254312B4 (en) * | 2002-11-21 | 2005-04-21 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Variable flow resistance |
AU2003213756A1 (en) * | 2002-11-21 | 2004-06-18 | California Institue Of Technology | Hydroimpedance pump |
WO2004052046A2 (en) * | 2002-11-27 | 2004-06-17 | Northwestern University | Thin membrane transducer |
US6920203B2 (en) * | 2002-12-02 | 2005-07-19 | General Electric Company | Method and apparatus for selectively attenuating a radiation source |
CN101158447B (en) | 2002-12-04 | 2012-12-26 | 斯宾克斯公司 | Devices and methods for programmable microscale manipulation of fluids |
US20040121474A1 (en) * | 2002-12-19 | 2004-06-24 | Genoptix, Inc | Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis |
US20040121307A1 (en) * | 2002-12-19 | 2004-06-24 | Genoptix, Inc | Early detection of cellular differentiation using optophoresis |
KR20050088476A (en) | 2002-12-30 | 2005-09-06 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | Methods and apparatus for pathogen detection and analysis |
US6866233B2 (en) * | 2003-01-03 | 2005-03-15 | Orbital Research Inc. | Reconfigurable porous technology for fluid flow control and method of controlling flow |
US7090471B2 (en) * | 2003-01-15 | 2006-08-15 | California Institute Of Technology | Integrated electrostatic peristaltic pump method and apparatus |
ATE432420T1 (en) * | 2003-03-10 | 2009-06-15 | Univ Michigan | INTEGRATED MICROFLUIDIC CONTROL DEVICE WITH PROGRAMMABLE TACTILE ACTUATORS |
US6844953B2 (en) * | 2003-03-12 | 2005-01-18 | Hewlett-Packard Development Company, L.P. | Micro-mirror device including dielectrophoretic liquid |
US20040179972A1 (en) * | 2003-03-14 | 2004-09-16 | Nanostream, Inc. | Systems and methods for detecting manufacturing defects in microfluidic devices |
US7279027B2 (en) * | 2003-03-21 | 2007-10-09 | Air Products And Chemicals, Inc. | Planar ceramic membrane assembly and oxidation reactor system |
US7249529B2 (en) | 2003-03-28 | 2007-07-31 | Protedyne Corporation | Robotically manipulable sample handling tool |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
EP2340890B1 (en) * | 2003-04-03 | 2016-10-19 | Fluidigm Corporation | Method of performimg digital PCR |
US7476363B2 (en) | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
EP1610888A2 (en) * | 2003-04-10 | 2006-01-04 | President And Fellows Of Harvard College | Formation and control of fluidic species |
US6929969B2 (en) * | 2003-04-23 | 2005-08-16 | Taiwan Semiconductor Manufacturing Company | Reflective spatial light modulator mirror device manufacturing process and layout method |
US8791171B2 (en) * | 2003-05-01 | 2014-07-29 | Abbott Cardiovascular Systems Inc. | Biodegradable coatings for implantable medical devices |
WO2004101151A1 (en) * | 2003-05-08 | 2004-11-25 | Nanostream, Inc. | Sample preparation for parallel chromatography |
US20050002025A1 (en) * | 2003-05-15 | 2005-01-06 | Toshiba Ceramics Co., Ltd. | Channel structure and process for production thereof |
US6962658B2 (en) * | 2003-05-20 | 2005-11-08 | Eksigent Technologies, Llc | Variable flow rate injector |
EP1636017A2 (en) | 2003-05-20 | 2006-03-22 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
FR2855076B1 (en) * | 2003-05-21 | 2006-09-08 | Inst Curie | MICROFLUIDIC DEVICE |
US7115230B2 (en) * | 2003-06-26 | 2006-10-03 | Intel Corporation | Hydrodynamic focusing devices |
US7381361B2 (en) | 2003-06-26 | 2008-06-03 | Intel Corporation | Fabricating structures in micro-fluidic channels based on hydrodynamic focusing |
ATE514791T1 (en) * | 2003-07-09 | 2011-07-15 | Genvault Corp | ROOM TEMPERATURE ELUTION OF NUCLEIC ACIDS |
WO2005007223A2 (en) * | 2003-07-16 | 2005-01-27 | Sasha John | Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations |
EP3718635A1 (en) | 2003-07-31 | 2020-10-07 | Handylab, Inc. | Processing particle-containing samples |
US7413712B2 (en) * | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
CN1867795B (en) * | 2003-08-11 | 2010-12-08 | 加州理工学院 | Microfluidic large scale integration |
US20050051489A1 (en) | 2003-08-20 | 2005-03-10 | California Institute Of Technology | IC-processed polymer nano-liquid chromatography system on-a-chip and method of making it |
CN104069784B (en) | 2003-08-27 | 2017-01-11 | 哈佛大学 | electronic control of fluidic species |
CN1860363B (en) * | 2003-08-28 | 2011-12-28 | 赛路拉公司 | Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network |
US7247778B2 (en) * | 2003-08-29 | 2007-07-24 | Spencer Chase | Addressable pneumatic valve system |
US7296592B2 (en) | 2003-09-16 | 2007-11-20 | Eksigent Technologies, Llc | Composite polymer microfluidic control device |
US7407630B2 (en) * | 2003-09-19 | 2008-08-05 | Applera Corporation | High density plate filler |
US20050226782A1 (en) * | 2003-09-19 | 2005-10-13 | Reed Mark T | High density plate filler |
US20060233673A1 (en) * | 2003-09-19 | 2006-10-19 | Beard Nigel P | High density plate filler |
US7998435B2 (en) * | 2003-09-19 | 2011-08-16 | Life Technologies Corporation | High density plate filler |
US20050220675A1 (en) * | 2003-09-19 | 2005-10-06 | Reed Mark T | High density plate filler |
US8277760B2 (en) * | 2003-09-19 | 2012-10-02 | Applied Biosystems, Llc | High density plate filler |
US7695688B2 (en) * | 2003-09-19 | 2010-04-13 | Applied Biosystems, Llc | High density plate filler |
US9492820B2 (en) | 2003-09-19 | 2016-11-15 | Applied Biosystems, Llc | High density plate filler |
US20060233671A1 (en) * | 2003-09-19 | 2006-10-19 | Beard Nigel P | High density plate filler |
US20060272738A1 (en) * | 2003-09-19 | 2006-12-07 | Gary Lim | High density plate filler |
CA2540035C (en) * | 2003-09-23 | 2012-11-20 | University Of North Carolina At Chapel Hill | Photocurable perfluoropolyethers for use as novel materials in microfluidic devices |
US20050232817A1 (en) * | 2003-09-26 | 2005-10-20 | The University Of Cincinnati | Functional on-chip pressure generator using solid chemical propellant |
US7284966B2 (en) * | 2003-10-01 | 2007-10-23 | Agency For Science, Technology & Research | Micro-pump |
US20050100712A1 (en) * | 2003-11-12 | 2005-05-12 | Simmons Blake A. | Polymerization welding and application to microfluidics |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
EP1542074A1 (en) * | 2003-12-11 | 2005-06-15 | Heptagon OY | Manufacturing a replication tool, sub-master or replica |
US7351380B2 (en) * | 2004-01-08 | 2008-04-01 | Sandia Corporation | Microfluidic structures and methods for integrating a functional component into a microfluidic device |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
US20050164373A1 (en) * | 2004-01-22 | 2005-07-28 | Oldham Mark F. | Diffusion-aided loading system for microfluidic devices |
SG10202107927VA (en) | 2004-01-25 | 2021-08-30 | Fluidigm Corp | Crystal forming devices and systems and methods for making and using the same |
US20050182312A1 (en) * | 2004-02-12 | 2005-08-18 | Medtronic Xomed, Inc. | Contact tonometer using MEMS technology |
US8158728B2 (en) | 2004-02-13 | 2012-04-17 | The University Of North Carolina At Chapel Hill | Methods and materials for fabricating microfluidic devices |
CA2555912A1 (en) * | 2004-02-13 | 2005-09-15 | The University Of North Carolina At Chapel Hill | Functional materials and novel methods for the fabrication of microfluidic devices |
EP1716254B1 (en) | 2004-02-19 | 2010-04-07 | Helicos Biosciences Corporation | Methods for analyzing polynucleotide sequences |
US20050196321A1 (en) * | 2004-03-03 | 2005-09-08 | Zhili Huang | Fluidic programmable array devices and methods |
WO2005087314A1 (en) * | 2004-03-11 | 2005-09-22 | Advanced Neuromodulation Systems, Inc. | Brain stimulation system and method |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
CN102778432A (en) * | 2004-05-02 | 2012-11-14 | 弗卢丁公司 | Thermal reaction device and using method thereof |
CN101811074B (en) * | 2004-05-02 | 2012-09-12 | 弗卢丁公司 | Thermal reaction equipment and using method thereof |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
ES2553097T3 (en) | 2004-05-03 | 2015-12-04 | Handylab, Inc. | Processing of samples containing polynucleotides |
US7694694B2 (en) * | 2004-05-10 | 2010-04-13 | The Aerospace Corporation | Phase-change valve apparatuses |
US8642353B2 (en) * | 2004-05-10 | 2014-02-04 | The Aerospace Corporation | Microfluidic device for inducing separations by freezing and associated method |
US7419639B2 (en) * | 2004-05-12 | 2008-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Multilayer microfluidic device |
BR122016013290B1 (en) | 2004-05-13 | 2021-04-20 | Anita Goel | nucleic acid molecule amplification device, microfluidic device for applying tension to nucleic acid molecules and kits for nucleic acid molecule processing |
DE602005016402D1 (en) * | 2004-05-24 | 2009-10-15 | Genvault Corp | STABLE STORAGE OF PROTEIN AND STABLE STORAGE OF NUCLEIC ACID IN RECYCLABLE FORM |
US8197234B2 (en) * | 2004-05-25 | 2012-06-12 | California Institute Of Technology | In-line actuator for electromagnetic operation |
US7799553B2 (en) | 2004-06-01 | 2010-09-21 | The Regents Of The University Of California | Microfabricated integrated DNA analysis system |
US7307802B2 (en) * | 2004-06-07 | 2007-12-11 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
US7686040B2 (en) * | 2004-06-24 | 2010-03-30 | The Aerospace Corporation | Electro-hydraulic devices |
US7721762B2 (en) * | 2004-06-24 | 2010-05-25 | The Aerospace Corporation | Fast acting valve apparatuses |
US7650910B2 (en) * | 2004-06-24 | 2010-01-26 | The Aerospace Corporation | Electro-hydraulic valve apparatuses |
US9477233B2 (en) | 2004-07-02 | 2016-10-25 | The University Of Chicago | Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets |
JP4412081B2 (en) * | 2004-07-07 | 2010-02-10 | 株式会社日立製作所 | Gas turbine and gas turbine cooling method |
US20060018795A1 (en) * | 2004-07-23 | 2006-01-26 | General Electric Company | Fabrication methods and multifunctional substrate materials for chemical and biological analysis in microfluidic systems |
US7244443B2 (en) | 2004-08-31 | 2007-07-17 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrophilic monomers |
DE102004042578A1 (en) * | 2004-09-02 | 2006-03-23 | Roche Diagnostics Gmbh | Micropump for pumping liquids with low flow rates in pressure / suction operation |
DE102004042987A1 (en) * | 2004-09-06 | 2006-03-23 | Roche Diagnostics Gmbh | Push-pull operated pump for a microfluidic system |
US7745207B2 (en) | 2006-02-03 | 2010-06-29 | IntegenX, Inc. | Microfluidic devices |
EP2261650A3 (en) | 2004-09-15 | 2011-07-06 | IntegenX Inc. | Microfluidic devices |
US20070243627A1 (en) * | 2004-09-30 | 2007-10-18 | Shuichi Takayama | Computerized control method and system for microfluidics and computer program product for use therein |
JP3922280B2 (en) * | 2004-09-30 | 2007-05-30 | セイコーエプソン株式会社 | Wiring pattern forming method and device manufacturing method |
US20060073035A1 (en) * | 2004-09-30 | 2006-04-06 | Narayan Sundararajan | Deformable polymer membranes |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US7832429B2 (en) * | 2004-10-13 | 2010-11-16 | Rheonix, Inc. | Microfluidic pump and valve structures and fabrication methods |
DE102004051394B4 (en) * | 2004-10-21 | 2006-08-17 | Advalytix Ag | Method for moving small amounts of liquid in microchannels and microchannel system |
US20060088449A1 (en) * | 2004-10-26 | 2006-04-27 | Massachusetts Institute Of Technology | Systems and methods for transferring a fluid sample |
KR100661347B1 (en) * | 2004-10-27 | 2006-12-27 | 삼성전자주식회사 | Micro thin film structure, micro electro mechanical system switch using the same and manufacturing method of them |
US20080264863A1 (en) * | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
US9260693B2 (en) | 2004-12-03 | 2016-02-16 | Cytonome/St, Llc | Actuation of parallel microfluidic arrays |
JP2008522795A (en) * | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | Microfluidic device with chemical reaction circuit |
DE502005005660D1 (en) | 2005-01-05 | 2008-11-20 | Olympus Life Science Res Europ | METHOD AND DEVICE FOR DOSING AND MIXING SMALL FLUID QUANTITIES |
DE102005000835B3 (en) * | 2005-01-05 | 2006-09-07 | Advalytix Ag | Method and device for dosing small quantities of liquid |
US7328882B2 (en) * | 2005-01-06 | 2008-02-12 | Honeywell International Inc. | Microfluidic modulating valve |
CA2591951C (en) * | 2005-01-10 | 2011-10-11 | Silverbrook Research Pty Ltd | Inkjet printhead production method |
US7465545B2 (en) * | 2005-01-29 | 2008-12-16 | Samsung Electronics Co., Ltd. | Microfluidic chip and manipulating apparatus having the same |
US7601554B1 (en) | 2005-01-31 | 2009-10-13 | The United States Of America As Represented By The Secretary Of The Air Force | Shaped MEMS contact |
US7235750B1 (en) | 2005-01-31 | 2007-06-26 | United States Of America As Represented By The Secretary Of The Air Force | Radio frequency MEMS switch contact metal selection |
DE102005005121A1 (en) * | 2005-02-04 | 2006-08-17 | Forschungszentrum Jülich GmbH | Process for the preparation of an elastomer and elastomer |
US20080009835A1 (en) * | 2005-02-17 | 2008-01-10 | Kriesel Marshall S | Fluid dispensing apparatus with flow rate control |
US20070054119A1 (en) * | 2005-03-04 | 2007-03-08 | Piotr Garstecki | Systems and methods of forming particles |
JP2008535644A (en) | 2005-03-04 | 2008-09-04 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | Method and apparatus for the formation of multiple emulsions |
EP2371453A1 (en) | 2005-03-18 | 2011-10-05 | Fluidigm Corporation | Microfluidic device |
US20060246493A1 (en) | 2005-04-04 | 2006-11-02 | Caliper Life Sciences, Inc. | Method and apparatus for use in temperature controlled processing of microfluidic samples |
KR20070120605A (en) * | 2005-04-14 | 2007-12-24 | 더 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Adjustable solubility in sacrificial layers for microfabrication |
US7883669B2 (en) | 2005-04-20 | 2011-02-08 | Fluidigm Corporation | Analysis engine and database for manipulating parameters for fluidic systems on a chip |
US7618391B2 (en) * | 2005-04-20 | 2009-11-17 | Children's Medical Center Corporation | Waveform sensing and regulating fluid flow valve |
US8140745B2 (en) | 2005-09-09 | 2012-03-20 | The Invention Science Fund I, Llc | Data retrieval methods |
US7512959B2 (en) * | 2005-05-09 | 2009-03-31 | Searete Llc | Rotation responsive disk activation and deactivation mechanisms |
US7668069B2 (en) * | 2005-05-09 | 2010-02-23 | Searete Llc | Limited use memory device with associated information |
US8462605B2 (en) * | 2005-05-09 | 2013-06-11 | The Invention Science Fund I, Llc | Method of manufacturing a limited use data storing device |
US7748012B2 (en) * | 2005-05-09 | 2010-06-29 | Searete Llc | Method of manufacturing a limited use data storing device |
US8159925B2 (en) | 2005-08-05 | 2012-04-17 | The Invention Science Fund I, Llc | Limited use memory device with associated information |
US7596073B2 (en) | 2005-05-09 | 2009-09-29 | Searete Llc | Method and system for fluid mediated disk activation and deactivation |
US8121016B2 (en) | 2005-05-09 | 2012-02-21 | The Invention Science Fund I, Llc | Rotation responsive disk activation and deactivation mechanisms |
US7907486B2 (en) | 2006-06-20 | 2011-03-15 | The Invention Science Fund I, Llc | Rotation responsive disk activation and deactivation mechanisms |
US8218262B2 (en) | 2005-05-09 | 2012-07-10 | The Invention Science Fund I, Llc | Method of manufacturing a limited use data storing device including structured data and primary and secondary read-support information |
US7668068B2 (en) * | 2005-06-09 | 2010-02-23 | Searete Llc | Rotation responsive disk activation and deactivation mechanisms |
US7565596B2 (en) * | 2005-09-09 | 2009-07-21 | Searete Llc | Data recovery systems |
US8099608B2 (en) | 2005-05-09 | 2012-01-17 | The Invention Science Fund I, Llc | Limited use data storing device |
US7770028B2 (en) * | 2005-09-09 | 2010-08-03 | Invention Science Fund 1, Llc | Limited use data storing device |
US7519980B2 (en) * | 2005-05-09 | 2009-04-14 | Searete Llc | Fluid mediated disk activation and deactivation mechanisms |
US7916592B2 (en) | 2005-05-09 | 2011-03-29 | The Invention Science Fund I, Llc | Fluid mediated disk activation and deactivation mechanisms |
US9396752B2 (en) | 2005-08-05 | 2016-07-19 | Searete Llc | Memory device activation and deactivation |
US8220014B2 (en) | 2005-05-09 | 2012-07-10 | The Invention Science Fund I, Llc | Modifiable memory devices having limited expected lifetime |
US7916615B2 (en) | 2005-06-09 | 2011-03-29 | The Invention Science Fund I, Llc | Method and system for rotational control of data storage devices |
US7694316B2 (en) * | 2005-05-09 | 2010-04-06 | The Invention Science Fund I, Llc | Fluid mediated disk activation and deactivation mechanisms |
US20090317798A1 (en) | 2005-06-02 | 2009-12-24 | Heid Christian A | Analysis using microfluidic partitioning devices |
CN101262948B (en) | 2005-06-06 | 2011-07-06 | 决策生物标志股份有限公司 | Assays based on liquid flow over arrays |
TWI288116B (en) * | 2005-06-07 | 2007-10-11 | Chien-Chung Fu | Method of manufacturing a LIGA mold by backside exposure |
US8309057B2 (en) * | 2005-06-10 | 2012-11-13 | The Invention Science Fund I, Llc | Methods for elevating neurotrophic agents |
KR101264673B1 (en) * | 2005-06-24 | 2013-05-20 | 엘지디스플레이 주식회사 | method for fabricating detail pattern by using soft mold |
TWI256905B (en) * | 2005-06-29 | 2006-06-21 | Univ Nat Cheng Kung | Method of forming micro-droplets and chips thereof |
US8628055B2 (en) | 2005-07-27 | 2014-01-14 | The Board Of Trustees Of The University Of Illinois | Bi-direction rapid action electrostatically actuated microvalve |
US20070048192A1 (en) * | 2005-08-10 | 2007-03-01 | Emil Kartalov | Integrated microfluidic vias, overpasses, underpasses, septums, microfuses, nested bioarrays and methods for fabricating the same |
US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
US20070054293A1 (en) * | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
EP1928603A1 (en) * | 2005-09-02 | 2008-06-11 | California Institute Of Technology | Method and apparatus for the mechanical actuation of valves in fluidic devices |
EP1938097A4 (en) * | 2005-09-09 | 2009-12-09 | Eksigent Technologies Llc | Variable flow rate system for column chromatography |
EP1938101A2 (en) * | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Microfluidic assay devices and methods |
US7390377B1 (en) * | 2005-09-22 | 2008-06-24 | Sandia Corporation | Bonding thermoplastic polymers |
US7611673B2 (en) * | 2005-09-28 | 2009-11-03 | California Institute Of Technology | PMDS microfluidic components and methods of operation of the same |
WO2007041486A2 (en) * | 2005-09-29 | 2007-04-12 | Siemens Medical Solutions Usa, Inc. | Microfluidic chip for synthesizing radioactively labeled molecules suitable for human imaging with positron emission tomography |
US8123834B2 (en) * | 2005-10-06 | 2012-02-28 | The Board Of Trustees Of The University Of Illinois | High gain selective metal organic framework preconcentrators |
WO2007044888A2 (en) * | 2005-10-11 | 2007-04-19 | The Johns Hopkins Univerisity | Microfluidic device and method for high-throughput cellular gradient and dose response studies |
US8822206B2 (en) * | 2005-10-11 | 2014-09-02 | The Johns Hopkins University | Device for high-throughput stimulation, immunostaining, and visualization of single cells |
US7727473B2 (en) | 2005-10-19 | 2010-06-01 | Progentech Limited | Cassette for sample preparation |
US8206975B2 (en) * | 2005-10-28 | 2012-06-26 | California Institute Of Technology | Method and device for regulating fluid flow in microfluidic devices |
US7913928B2 (en) | 2005-11-04 | 2011-03-29 | Alliant Techsystems Inc. | Adaptive structures, systems incorporating same and related methods |
US20070106200A1 (en) * | 2005-11-08 | 2007-05-10 | Brian Levy | Intraocular shunt device and method |
US9474712B2 (en) | 2005-11-09 | 2016-10-25 | Gearbox, Llc | In situ reaction device |
US8936590B2 (en) | 2005-11-09 | 2015-01-20 | The Invention Science Fund I, Llc | Acoustically controlled reaction device |
US20070106271A1 (en) * | 2005-11-09 | 2007-05-10 | Searete Llc, A Limited Liability Corporation | Remote control of substance delivery system |
US8083710B2 (en) | 2006-03-09 | 2011-12-27 | The Invention Science Fund I, Llc | Acoustically controlled substance delivery device |
US9028467B2 (en) * | 2005-11-09 | 2015-05-12 | The Invention Science Fund I, Llc | Osmotic pump with remotely controlled osmotic pressure generation |
US20070178133A1 (en) * | 2005-11-09 | 2007-08-02 | Liquidia Technologies, Inc. | Medical device, materials, and methods |
US8273071B2 (en) | 2006-01-18 | 2012-09-25 | The Invention Science Fund I, Llc | Remote controller for substance delivery system |
US20070106277A1 (en) * | 2005-11-09 | 2007-05-10 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Remote controller for substance delivery system |
US8992511B2 (en) | 2005-11-09 | 2015-03-31 | The Invention Science Fund I, Llc | Acoustically controlled substance delivery device |
EP1790861A1 (en) * | 2005-11-25 | 2007-05-30 | Bonsens AB | Microfluidic system |
US7986686B2 (en) | 2005-11-25 | 2011-07-26 | Cisco Technology, Inc. | Techniques for distributing network provider digital content to customer premises nodes |
CA2636855C (en) | 2006-01-11 | 2016-09-27 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
DE102006002924B3 (en) * | 2006-01-20 | 2007-09-13 | Albert-Ludwigs-Universität Freiburg | Fluid handling device and method of handling a fluid |
US8021582B2 (en) * | 2006-01-23 | 2011-09-20 | National Cheng Kung University | Method for producing microparticles in a continuous phase liquid |
US20070248971A1 (en) * | 2006-01-26 | 2007-10-25 | California Institute Of Technology | Programming microfluidic devices with molecular information |
DE602007009811D1 (en) * | 2006-01-27 | 2010-11-25 | Harvard College | COALESCENCE FLUIDER DROPLET |
US7749365B2 (en) | 2006-02-01 | 2010-07-06 | IntegenX, Inc. | Optimized sample injection structures in microfluidic separations |
US8124015B2 (en) | 2006-02-03 | 2012-02-28 | Institute For Systems Biology | Multiplexed, microfluidic molecular assay device and assay method |
US7862000B2 (en) * | 2006-02-03 | 2011-01-04 | California Institute Of Technology | Microfluidic method and structure with an elastomeric gas-permeable gasket |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
EP1998829B1 (en) | 2006-03-14 | 2011-02-09 | University Of Southern California | Mems device for delivery of therapeutic agents |
US7766033B2 (en) | 2006-03-22 | 2010-08-03 | The Regents Of The University Of California | Multiplexed latching valves for microfluidic devices and processors |
WO2007112114A2 (en) | 2006-03-24 | 2007-10-04 | Handylab, Inc. | Integrated system for processing microfluidic samples, and method of using same |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
CN101479605A (en) * | 2006-04-21 | 2009-07-08 | 纳诺拜希姆公司 | Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviralagents |
US8828661B2 (en) | 2006-04-24 | 2014-09-09 | Fluidigm Corporation | Methods for detection and quantification of nucleic acid or protein targets in a sample |
BRPI0711047A2 (en) * | 2006-05-01 | 2011-08-23 | Konink Philips Eletronics N V | fluid sample conveying device and use thereof |
US20070260174A1 (en) * | 2006-05-05 | 2007-11-08 | Searete Llc | Detecting a failure to maintain a regimen |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
EP4190448A3 (en) | 2006-05-11 | 2023-09-20 | Bio-Rad Laboratories, Inc. | Microfluidic devices |
JP4721227B2 (en) * | 2006-05-22 | 2011-07-13 | アイダエンジニアリング株式会社 | Microchannel chip and manufacturing method thereof |
US8679741B2 (en) * | 2006-05-31 | 2014-03-25 | Sequenom, Inc. | Methods and compositions for the extraction and amplification of nucleic acid from a sample |
CA2653557A1 (en) * | 2006-06-02 | 2008-03-13 | The Board Of Trustees Of The University Of Illinois | Soft mems |
US20090016333A1 (en) * | 2006-06-14 | 2009-01-15 | Derek Wang | Content-based adaptive jitter handling |
US8432777B2 (en) | 2006-06-19 | 2013-04-30 | The Invention Science Fund I, Llc | Method and system for fluid mediated disk activation and deactivation |
US8264928B2 (en) | 2006-06-19 | 2012-09-11 | The Invention Science Fund I, Llc | Method and system for fluid mediated disk activation and deactivation |
DE102006030068A1 (en) | 2006-06-28 | 2008-01-03 | M2P-Labs Gmbh | Apparatus and method for the supply and removal of fluids in shaken microreactors arrays |
US9028859B2 (en) | 2006-07-07 | 2015-05-12 | Advanced Cardiovascular Systems, Inc. | Phase-separated block copolymer coatings for implantable medical devices |
WO2008079440A2 (en) | 2006-07-10 | 2008-07-03 | Medipacs, Inc. | Super elastic epoxy hydrogel |
US7959876B2 (en) * | 2006-07-17 | 2011-06-14 | Industrial Technology Research Institute | Fluidic device |
US7794665B2 (en) * | 2006-07-17 | 2010-09-14 | Industrial Technology Research Institute | Fluidic device |
US20080021364A1 (en) * | 2006-07-17 | 2008-01-24 | Industrial Technology Research Institute | Fluidic device |
CN101109761B (en) * | 2006-07-17 | 2012-05-30 | 财团法人工业技术研究院 | Fluidic device and control method thereof |
WO2008091294A2 (en) * | 2006-07-28 | 2008-07-31 | California Institute Of Technology | Polymer nems for cell physiology and microfabricated cell positioning system for micro-biocalorimeter |
EP2047157A1 (en) * | 2006-08-02 | 2009-04-15 | The Regents of the University of Michigan | Multiplexed microfluidic valve activator |
US9012390B2 (en) | 2006-08-07 | 2015-04-21 | Raindance Technologies, Inc. | Fluorocarbon emulsion stabilizing surfactants |
US7817698B2 (en) * | 2006-08-11 | 2010-10-19 | California Institute Of Technology | Mechanically tunable elastomeric optofluidic distributed feedback dye lasers |
TW200808957A (en) * | 2006-08-15 | 2008-02-16 | Univ Nat Cheng Kung | Chip for cell culture |
US8050516B2 (en) | 2006-09-13 | 2011-11-01 | Fluidigm Corporation | Methods and systems for determining a baseline during image processing |
US8055034B2 (en) | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
US20080131327A1 (en) * | 2006-09-28 | 2008-06-05 | California Institute Of Technology | System and method for interfacing with a microfluidic chip |
US8936932B2 (en) * | 2006-10-12 | 2015-01-20 | Koninklijke Philips N.V. | Magnetic and/or electric label assisted detection system and method |
US8123192B2 (en) * | 2006-10-18 | 2012-02-28 | California Institute Of Technology | Control arrangement for microfluidic devices and related methods and systems |
US7790118B2 (en) * | 2006-10-18 | 2010-09-07 | California Institute Of Technology | Microfluidic devices and related methods and systems |
US8841116B2 (en) | 2006-10-25 | 2014-09-23 | The Regents Of The University Of California | Inline-injection microdevice and microfabricated integrated DNA analysis system using same |
DE602006009405D1 (en) | 2006-10-28 | 2009-11-05 | Sensirion Holding Ag | More cell pump |
US8540677B2 (en) * | 2006-11-02 | 2013-09-24 | Becton, Dickinson And Company | Vascular access device chamber venting |
WO2008061043A2 (en) | 2006-11-10 | 2008-05-22 | Glaukos Corporation | Uveoscleral shunt and methods for implanting same |
US8765076B2 (en) | 2006-11-14 | 2014-07-01 | Handylab, Inc. | Microfluidic valve and method of making same |
US20100171054A1 (en) * | 2006-11-28 | 2010-07-08 | Astc Aerospace Ab | Micromechanical slow acting valve system |
WO2008067552A2 (en) | 2006-11-30 | 2008-06-05 | Fluidigm Corporation | Method and apparatus for biological sample analysis |
US8128393B2 (en) | 2006-12-04 | 2012-03-06 | Liquidia Technologies, Inc. | Methods and materials for fabricating laminate nanomolds and nanoparticles therefrom |
US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
EP1931158B1 (en) * | 2006-12-08 | 2013-04-10 | Samsung Electronics Co., Ltd. | Apparatus and method for selecting frame structure in multihop relay broadband wireless access communication system |
US7932034B2 (en) | 2006-12-20 | 2011-04-26 | The Board Of Trustees Of The Leland Stanford Junior University | Heat and pH measurement for sequencing of DNA |
US20080160603A1 (en) * | 2006-12-28 | 2008-07-03 | Narayan Sundararajan | Flow stabilization in micro-and nanofluidic devices |
US20080163946A1 (en) * | 2006-12-28 | 2008-07-10 | The Trustees Of California State University | Magnetically controlled valve for flow manipulation in polymer microfluidic devices |
GB2445739A (en) * | 2007-01-16 | 2008-07-23 | Lab901 Ltd | Polymeric laminates containing heat seals |
EP2125219B1 (en) | 2007-01-19 | 2016-08-10 | Fluidigm Corporation | High precision microfluidic devices and methods |
US7829032B2 (en) * | 2007-01-23 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography |
KR20100028526A (en) | 2007-02-05 | 2010-03-12 | 마이크로칩 바이오테크놀로지스, 인크. | Microfluidic and nanofluidic devices, systems, and applications |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US7871570B2 (en) * | 2007-02-23 | 2011-01-18 | Joseph Zhili Huang | Fluidic array devices and systems, and related methods of use and manufacturing |
US20100112681A1 (en) * | 2007-03-05 | 2010-05-06 | Nec Corporation | Microchip fluid control mechanism |
CN102014871A (en) * | 2007-03-28 | 2011-04-13 | 哈佛大学 | Emulsions and techniques for formation |
US20080258036A1 (en) * | 2007-03-30 | 2008-10-23 | Labrador Research Llc | System for dimensional stability of elastomeric microdevices |
KR101448208B1 (en) | 2007-04-09 | 2014-10-10 | 한국생명공학연구원 | A microfluidic array system for biological, chemical, and biochemical assessments |
US8071035B2 (en) * | 2007-04-12 | 2011-12-06 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US7974380B2 (en) * | 2007-05-09 | 2011-07-05 | Fluidigm Corporation | Method and system for crystallization and X-ray diffraction screening |
US7952261B2 (en) | 2007-06-29 | 2011-05-31 | Bayer Materialscience Ag | Electroactive polymer transducers for sensory feedback applications |
WO2009009131A2 (en) | 2007-07-11 | 2009-01-15 | California Institute Of Technology | Cardiac assist system using helical arrangement of contractile bands and helically-twisting cardiac assist device |
JP5651011B2 (en) | 2007-07-13 | 2015-01-07 | ハンディーラブ インコーポレイテッド | Polynucleotide capture material and method of use thereof |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
AU2013205268B2 (en) * | 2007-07-13 | 2015-03-19 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
US8016260B2 (en) * | 2007-07-19 | 2011-09-13 | Formulatrix, Inc. | Metering assembly and method of dispensing fluid |
US8454906B2 (en) | 2007-07-24 | 2013-06-04 | The Regents Of The University Of California | Microfabricated droplet generator for single molecule/cell genetic analysis in engineered monodispersed emulsions |
US8206025B2 (en) * | 2007-08-07 | 2012-06-26 | International Business Machines Corporation | Microfluid mixer, methods of use and methods of manufacture thereof |
KR101321912B1 (en) * | 2007-08-28 | 2013-10-30 | 삼성전자주식회사 | Elastic valve and microfluidic device with the same |
EP2195452B1 (en) | 2007-08-29 | 2012-03-14 | Sequenom, Inc. | Methods and compositions for universal size-specific polymerase chain reaction |
CA2698545C (en) | 2007-09-07 | 2014-07-08 | Fluidigm Corporation | Copy number variation determination, methods and systems |
CA2700946A1 (en) * | 2007-09-28 | 2009-04-02 | University Of Toronto | A system, apparatus and method for applying mechanical force to a material |
EP2212437A4 (en) | 2007-11-07 | 2011-09-28 | Univ British Columbia | Microfluidic device and method of using same |
JP2009128037A (en) * | 2007-11-20 | 2009-06-11 | Canon Inc | Micro fluid device |
US8152136B2 (en) * | 2007-11-26 | 2012-04-10 | The Hong Kong Polytechnic University | Polymer microvalve with actuators and devices |
DE102007060352A1 (en) | 2007-12-12 | 2009-06-18 | Richter, Andreas, Dr. | Device for electronically compatible thermal controlling of integrated micro-systems on basis of active temperature sensitive hydraulic gels, has component, which produces temperature field |
US8561963B2 (en) * | 2007-12-19 | 2013-10-22 | Palo Alto Research Center Incorporated | Electrostatically addressable microvalves |
JP5542691B2 (en) | 2007-12-20 | 2014-07-09 | ユニバーシティ オブ サザン カリフォルニア | Devices and methods for delivering therapeutic agents |
US8152908B2 (en) | 2008-01-16 | 2012-04-10 | The Board Of Trustees Of The University Of Illinois | Micromachined gas chromatography columns for fast separation of Organophosphonate and Organosulfur compounds and methods for deactivating same |
EP2245191A1 (en) | 2008-01-17 | 2010-11-03 | Sequenom, Inc. | Single molecule nucleic acid sequence analysis processes and compositions |
US9138700B2 (en) * | 2008-01-18 | 2015-09-22 | The Regents Of The University Of California | Accurate and rapid micromixer for integrated microfluidic devices |
EP2234916A4 (en) | 2008-01-22 | 2016-08-10 | Integenx Inc | Universal sample preparation system and use in an integrated analysis system |
US9157116B2 (en) | 2008-02-08 | 2015-10-13 | Fluidigm Corporation | Combinatorial amplification and detection of nucleic acids |
KR100952056B1 (en) * | 2008-02-29 | 2010-04-07 | 아주대학교산학협력단 | Cell-chip and automatic controlled system capable of detecting conditions for optimizing differentiation of stem cell using mechanical stimuls |
CA2717320A1 (en) | 2008-03-11 | 2009-09-17 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
EP2259072A4 (en) | 2008-03-24 | 2016-03-30 | Nec Corp | Flow passage control mechanism for microchip |
US8269029B2 (en) | 2008-04-08 | 2012-09-18 | The Board Of Trustees Of The University Of Illinois | Water repellent metal-organic frameworks, process for making and uses regarding same |
CN102056838B (en) * | 2008-04-11 | 2013-07-03 | 弗卢丁公司 | Microfluidic device and methods |
US8096784B2 (en) * | 2008-04-16 | 2012-01-17 | National Taiwan Ocean University | Bi-directional continuous peristaltic micro-pump |
US8961902B2 (en) * | 2008-04-23 | 2015-02-24 | Bioscale, Inc. | Method and apparatus for analyte processing |
US8231609B2 (en) | 2008-05-08 | 2012-07-31 | Minipumps, Llc | Drug-delivery pumps and methods of manufacture |
EP2320989B1 (en) | 2008-05-08 | 2015-03-11 | MiniPumps, LLC | Implantable pumps and cannulas therefor |
US9199035B2 (en) | 2008-05-08 | 2015-12-01 | Minipumps, Llc. | Drug-delivery pumps with dynamic, adaptive control |
US9333297B2 (en) | 2008-05-08 | 2016-05-10 | Minipumps, Llc | Drug-delivery pump with intelligent control |
CN105344389B (en) | 2008-05-16 | 2018-01-02 | 哈佛大学 | Microfluid system, method and apparatus |
TWI350891B (en) * | 2008-05-27 | 2011-10-21 | Ying Chyi Chou | Omnibus quasi-hydrosystem |
US7999257B2 (en) | 2008-06-02 | 2011-08-16 | Taiwan Semiconductor Manufacturing Company, Ltd. | Process for eliminating delamination between amorphous silicon layers |
DE102008002336A1 (en) | 2008-06-10 | 2009-12-24 | Robert Bosch Gmbh | Pinch valve and method for its production |
JP2011525166A (en) * | 2008-06-13 | 2011-09-15 | エメラルド バイオストラクチャーズ, インコーポレイテッド | Nanovolume microcapillary crystallization system |
WO2009155612A2 (en) * | 2008-06-20 | 2009-12-23 | Genvault Corporation | Sample collection and storage devices and methods of use thereof |
US20090315126A1 (en) * | 2008-06-20 | 2009-12-24 | Silverbrook Research Pty Ltd | Bonded Microfluidic System Comprising Thermal Bend Actuated Valve |
US20090314368A1 (en) * | 2008-06-20 | 2009-12-24 | Silverbrook Research Pty Ltd | Microfluidic System Comprising Pinch Valve and On-Chip MEMS Pump |
GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
CN101960144A (en) * | 2008-07-08 | 2011-01-26 | 松下电器产业株式会社 | Fluid conveying device using electrically conductive polymer |
USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
EP2143492A1 (en) * | 2008-07-11 | 2010-01-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method and microfluidic device for combining reaction components contained in liquids |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
US7976789B2 (en) * | 2008-07-22 | 2011-07-12 | The Board Of Trustees Of The University Of Illinois | Microfluidic device for preparing mixtures |
CN102165076B (en) | 2008-07-25 | 2014-07-09 | 弗卢丁公司 | Method and system for manufacturing integrated fluidic chips |
WO2010017210A1 (en) | 2008-08-07 | 2010-02-11 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
DE102008038462B4 (en) | 2008-08-20 | 2010-06-17 | Advanced Display Technology Ag | Fluidic display device and method therefor |
US20100059120A1 (en) * | 2008-09-11 | 2010-03-11 | General Electric Company | Microfluidic device and methods for droplet generation and manipulation |
EP2334792B1 (en) | 2008-09-12 | 2020-09-09 | GenTegra LLC | Matrices and media for storage and stabilization of biomolecules |
US8962247B2 (en) * | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
WO2010033639A2 (en) | 2008-09-16 | 2010-03-25 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
US8082810B2 (en) * | 2008-09-29 | 2011-12-27 | Ysi Incorporated | Microfluidic elastic micro-aliquotter |
US20100093098A1 (en) * | 2008-10-14 | 2010-04-15 | Siemens Medical Solutions | Nonflow-through appratus and mehod using enhanced flow mechanisms |
US20100102261A1 (en) * | 2008-10-28 | 2010-04-29 | Microfluidic Systems, Inc. | Microfluidic valve mechanism |
DK2376226T3 (en) | 2008-12-18 | 2018-10-15 | Opko Diagnostics Llc | IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES |
JP4824743B2 (en) * | 2008-12-26 | 2011-11-30 | アイダエンジニアリング株式会社 | Microchannel chip |
KR20110111449A (en) | 2008-12-31 | 2011-10-11 | 인터젠엑스 인크. | Instrument with microfluidic chip |
US8058630B2 (en) * | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
US8100293B2 (en) | 2009-01-23 | 2012-01-24 | Formulatrix, Inc. | Microfluidic dispensing assembly |
CN104878086A (en) | 2009-02-11 | 2015-09-02 | 卡里斯Mpi公司 | Molecular Profiling For Personalized Medicine |
US8989230B2 (en) | 2009-02-20 | 2015-03-24 | Vixar | Method and apparatus including movable-mirror mems-tuned surface-emitting lasers |
US9700038B2 (en) | 2009-02-25 | 2017-07-11 | Genea Limited | Cryopreservation of biological cells and tissues |
CA2755615A1 (en) * | 2009-03-18 | 2010-09-23 | Sequenom, Inc. | Use of thermostable endonucleases for generating reporter molecules |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
US8691509B2 (en) | 2009-04-02 | 2014-04-08 | Fluidigm Corporation | Multi-primer amplification method for barcoding of target nucleic acids |
EP3211095B1 (en) | 2009-04-03 | 2019-01-02 | Sequenom, Inc. | Nucleic acid preparation compositions and methods |
EP2239793A1 (en) | 2009-04-11 | 2010-10-13 | Bayer MaterialScience AG | Electrically switchable polymer film structure and use thereof |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
DE102009023430B4 (en) * | 2009-05-29 | 2013-07-25 | Siemens Aktiengesellschaft | Apparatus and method for controlling fluid flows in lab-on-a-chip systems and method of manufacturing the apparatus |
DE102009023429B4 (en) | 2009-05-29 | 2013-08-14 | Siemens Aktiengesellschaft | Valve for lab-on-a-chip systems, method for actuating and producing the valve |
KR20120030130A (en) | 2009-06-02 | 2012-03-27 | 인터젠엑스 인크. | Fluidic devices with diaphragm valves |
CA2764678C (en) | 2009-06-04 | 2017-12-12 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for dna analysis |
AU2010256429B2 (en) | 2009-06-05 | 2015-09-17 | Integenx Inc. | Universal sample preparation system and use in an integrated analysis system |
US8623288B1 (en) | 2009-06-29 | 2014-01-07 | Nanosys, Inc. | Apparatus and methods for high density nanowire growth |
US8551787B2 (en) | 2009-07-23 | 2013-10-08 | Fluidigm Corporation | Microfluidic devices and methods for binary mixing |
KR101274113B1 (en) * | 2009-09-01 | 2013-06-13 | 한국전자통신연구원 | Magnetic microvalve using metal ball and manufacturing method thereof |
WO2011028764A2 (en) | 2009-09-02 | 2011-03-10 | President And Fellows Of Harvard College | Multiple emulsions created using jetting and other techniques |
SG169918A1 (en) | 2009-10-02 | 2011-04-29 | Fluidigm Corp | Microfluidic devices with removable cover and methods of fabrication and application |
KR101252829B1 (en) * | 2009-10-06 | 2013-04-11 | 한국전자통신연구원 | Array apparatus for separation of single cell |
WO2011042564A1 (en) | 2009-10-09 | 2011-04-14 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
EP2494077A4 (en) | 2009-10-27 | 2013-08-21 | Caris Mpi Inc | Molecular profiling for personalized medicine |
US8145114B2 (en) | 2009-10-29 | 2012-03-27 | Eastman Kodak Company | Digital manufacture of a microfluidic device |
US20110143378A1 (en) * | 2009-11-12 | 2011-06-16 | CyVek LLC. | Microfluidic method and apparatus for high performance biological assays |
CA2781556C (en) | 2009-11-23 | 2015-05-19 | Cyvek, Inc. | Method and apparatus for performing assays |
US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
US9216412B2 (en) | 2009-11-23 | 2015-12-22 | Cyvek, Inc. | Microfluidic devices and methods of manufacture and use |
US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
US10022696B2 (en) | 2009-11-23 | 2018-07-17 | Cyvek, Inc. | Microfluidic assay systems employing micro-particles and methods of manufacture |
WO2011066588A1 (en) | 2009-11-30 | 2011-06-03 | Fluidigm Corporation | Microfluidic device regeneration |
US8584703B2 (en) | 2009-12-01 | 2013-11-19 | Integenx Inc. | Device with diaphragm valve |
IT1397819B1 (en) * | 2009-12-17 | 2013-02-04 | Silicon Biosystems Spa | MICROFLUID SYSTEM |
ES2577017T3 (en) | 2009-12-22 | 2016-07-12 | Sequenom, Inc. | Procedures and kits to identify aneuploidy |
EP2517025B1 (en) | 2009-12-23 | 2019-11-27 | Bio-Rad Laboratories, Inc. | Methods for reducing the exchange of molecules between droplets |
EP2528687B1 (en) | 2010-01-29 | 2018-08-22 | Micronics, Inc. | System comprising a host instrument and a microfluidic cartridge for assays |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
CA2789425C (en) | 2010-02-12 | 2020-04-28 | Raindance Technologies, Inc. | Digital analyte analysis with polymerase error correction |
JP5808349B2 (en) | 2010-03-01 | 2015-11-10 | カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー | Biomarkers for theranosis |
KR101177981B1 (en) * | 2010-03-04 | 2012-08-28 | 전북대학교산학협력단 | Process for the Preparation of 3D Spiral and Helical Photonic Actuators |
IT1399361B1 (en) * | 2010-03-31 | 2013-04-16 | Milano Politecnico | METHOD FOR THE REALIZATION OF A MICROFLUIDIC DEVICE AND DEVICE DERIVING FROM THE SAME |
WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
WO2011134038A1 (en) | 2010-04-26 | 2011-11-03 | National Research Council Of Canada | Semipermanently closed microfluidic valve |
US9267618B2 (en) | 2010-05-18 | 2016-02-23 | Samsung Electronics Co., Ltd. | Microvalve device and method of manufacturing the same |
US8512538B2 (en) | 2010-05-28 | 2013-08-20 | Integenx Inc. | Capillary electrophoresis device |
ES2948493T3 (en) | 2010-05-28 | 2023-09-13 | Genea Ip Holdings Pty Ltd | Improved micromanipulation and storage devices and methods |
KR20110136629A (en) * | 2010-06-15 | 2011-12-21 | 삼성전자주식회사 | Microfluidic device comprising microvalve |
US8900763B2 (en) | 2010-06-18 | 2014-12-02 | Myfc Ab | Electrochemically actuated valve |
GB2481425A (en) | 2010-06-23 | 2011-12-28 | Iti Scotland Ltd | Method and device for assembling polynucleic acid sequences |
US9125655B2 (en) | 2010-07-16 | 2015-09-08 | California Institute Of Technology | Correction and optimization of wave reflection in blood vessels |
WO2012024657A1 (en) | 2010-08-20 | 2012-02-23 | IntegenX, Inc. | Microfluidic devices with mechanically-sealed diaphragm valves |
EP2606154B1 (en) | 2010-08-20 | 2019-09-25 | Integenx Inc. | Integrated analysis system |
WO2012045012A2 (en) | 2010-09-30 | 2012-04-05 | Raindance Technologies, Inc. | Sandwich assays in droplets |
MX2013004184A (en) | 2010-10-15 | 2013-07-29 | Lockheed Corp | Micro fluidic optic design. |
WO2012054933A2 (en) | 2010-10-22 | 2012-04-26 | Fluidigm Corporation | Universal probe assay methods |
DE102010051743B4 (en) | 2010-11-19 | 2022-09-01 | C. Miethke Gmbh & Co. Kg | Programmable hydrocephalus valve |
US9364803B2 (en) | 2011-02-11 | 2016-06-14 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
KR20120096175A (en) * | 2011-02-22 | 2012-08-30 | 엘지전자 주식회사 | Frame system for solar cell module |
SG193003A1 (en) | 2011-03-01 | 2013-10-30 | Bayer Ip Gmbh | Automated manufacturing processes for producing deformable polymer devices and films |
EP2689284A4 (en) | 2011-03-22 | 2014-08-20 | Bayer Ip Gmbh | Electroactive polymer actuator lenticular system |
US9168531B2 (en) | 2011-03-24 | 2015-10-27 | Fluidigm Corporation | Method for thermal cycling of microfluidic samples |
ES2617599T3 (en) | 2011-04-15 | 2017-06-19 | Becton, Dickinson And Company | Real-time scanning microfluidic thermocycler and methods for synchronized thermocycling and optical scanning detection |
US8574513B2 (en) * | 2011-04-20 | 2013-11-05 | California Institute Of Technology | Single-layer PCB microfluidics |
US8460872B2 (en) | 2011-04-29 | 2013-06-11 | Sequenom, Inc. | Quantification of a minority nucleic acid species |
US8857275B2 (en) | 2011-05-02 | 2014-10-14 | California Institute Of Technology | NEMS sensors for cell force application and measurement |
CN104023834B (en) | 2011-05-04 | 2016-09-28 | 卢米耐克斯公司 | The apparatus and method for prepared for integrated sample, react and detect |
WO2012154876A1 (en) | 2011-05-09 | 2012-11-15 | Fluidigm Corporation | Probe based nucleic acid detection |
US9644231B2 (en) | 2011-05-09 | 2017-05-09 | Fluidigm Corporation | Nucleic acid detection using probes |
EP2714254B1 (en) | 2011-05-23 | 2017-09-06 | President and Fellows of Harvard College | Control of emulsions, including multiple emulsions |
JP4934750B1 (en) * | 2011-05-31 | 2012-05-16 | 株式会社メトラン | Pump unit, breathing assistance device |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
US9556470B2 (en) | 2011-06-02 | 2017-01-31 | Raindance Technologies, Inc. | Enzyme quantification |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
EP3120923A3 (en) | 2011-07-06 | 2017-03-01 | President and Fellows of Harvard College | Article comprising a particle having a shell and a fluid |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
US9088134B2 (en) | 2011-07-27 | 2015-07-21 | Vixar Inc. | Method and apparatus including improved vertical-cavity surface-emitting lasers |
WO2013049706A1 (en) | 2011-09-30 | 2013-04-04 | Becton, Dickinson And Company | Unitized reagent strip |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
US8894946B2 (en) | 2011-10-21 | 2014-11-25 | Integenx Inc. | Sample preparation, processing and analysis systems |
US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
EP2773892B1 (en) | 2011-11-04 | 2020-10-07 | Handylab, Inc. | Polynucleotide sample preparation device |
WO2013072790A1 (en) | 2011-11-16 | 2013-05-23 | International Business Machines Corporation | Microfluidic device with deformable valve |
CN104204812B (en) | 2012-02-03 | 2018-01-05 | 贝克顿·迪金森公司 | The external file that compatibility determines between distributing and test for molecule diagnostic test |
WO2013126483A1 (en) * | 2012-02-21 | 2013-08-29 | Fluidigm Corporation | Method and systems for microfluidic logic devices |
US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
FR2987282B1 (en) | 2012-02-24 | 2017-12-29 | Fonds De L'espci Georges Charpak | MICROCANAL WITH OPENING AND / OR CLOSING AND / OR PUMPING DEVICE |
US9506845B2 (en) | 2012-02-29 | 2016-11-29 | Fluidigm Corporation | Methods, systems and devices for multiple single-cell capturing and processing using microfluidics |
EP3401399B1 (en) | 2012-03-02 | 2020-04-22 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
WO2013133792A1 (en) | 2012-03-05 | 2013-09-12 | Empire Technology Development Llc | Flexible circuits |
EP2822689B1 (en) | 2012-03-08 | 2023-07-26 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
US10000605B2 (en) | 2012-03-14 | 2018-06-19 | Medipacs, Inc. | Smart polymer materials with excess reactive molecules |
US9876160B2 (en) | 2012-03-21 | 2018-01-23 | Parker-Hannifin Corporation | Roll-to-roll manufacturing processes for producing self-healing electroactive polymer devices |
JP6465490B2 (en) | 2012-03-26 | 2019-02-06 | グローコス コーポレーション | Implant delivery device |
US20150050172A1 (en) * | 2012-03-26 | 2015-02-19 | Alere San Diego, Inc. | Microfluidic pump |
EP4201327A1 (en) | 2012-03-30 | 2023-06-28 | Insulet Corporation | Fluid delivery device with transcutaneous access tool, insertion mechanism and blood glucose monitoring for use therewith |
AU2013204332B2 (en) | 2012-04-16 | 2015-07-16 | Commonwealth Scientific And Industrial Research Organisation | Methods and systems for detecting an analyte or classifying a sample |
US9238833B2 (en) | 2012-04-17 | 2016-01-19 | California Institute Of Technology | Thermally controlled chamber with optical access for high-performance PCR |
US9080941B2 (en) | 2012-04-27 | 2015-07-14 | General Electric Company | Microfluidic flow cell assemblies for imaging and method of use |
US9150907B2 (en) | 2012-04-27 | 2015-10-06 | General Electric Company | Microfluidic flow cell assemblies and method of use |
WO2013177206A2 (en) | 2012-05-21 | 2013-11-28 | Fluidigm Corporation | Single-particle analysis of particle populations |
US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
WO2013192143A1 (en) | 2012-06-18 | 2013-12-27 | Bayer Intellectual Property Gmbh | Stretch frame for stretching process |
US20140004105A1 (en) | 2012-06-29 | 2014-01-02 | Sequenom, Inc. | Age-related macular degeneration diagnostics |
CA2878979C (en) | 2012-07-13 | 2021-09-14 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
US8519644B1 (en) * | 2012-08-15 | 2013-08-27 | Transmute, Inc. | Accelerator having acceleration channels formed between covalently bonded chips |
WO2014043635A1 (en) * | 2012-09-14 | 2014-03-20 | President And Fellows Of Harvard College | Microfluidic assisted cell screening |
GB2506630A (en) * | 2012-10-04 | 2014-04-09 | Univ Leiden | Method and apparatus for processing a liquid |
CA2887094C (en) | 2012-10-04 | 2021-09-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
JP6396911B2 (en) | 2012-10-15 | 2018-09-26 | ナノセレクト バイオメディカル, インコーポレイテッド | System, apparatus and method for sorting particles |
EP4170031A1 (en) | 2012-10-23 | 2023-04-26 | Caris Science, Inc. | Aptamers and uses thereof |
US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
WO2014066576A1 (en) | 2012-10-24 | 2014-05-01 | Bayer Intellectual Property Gmbh | Polymer diode |
US9857333B2 (en) | 2012-10-31 | 2018-01-02 | Berkeley Lights, Inc. | Pens for biological micro-objects |
US9549666B2 (en) | 2012-11-10 | 2017-01-24 | Curvo Medical, Inc. | Coaxial micro-endoscope |
US9233225B2 (en) | 2012-11-10 | 2016-01-12 | Curvo Medical, Inc. | Coaxial bi-directional catheter |
US20140142438A1 (en) * | 2012-11-19 | 2014-05-22 | Biosense Webster (Israel), Ltd. | Using location and force measurements to estimate tissue thickness |
AU2013361323B2 (en) | 2012-12-19 | 2018-09-06 | Caris Science, Inc. | Compositions and methods for aptamer screening |
WO2014100732A1 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Fluidic circuits and related manufacturing methods |
CN107824233B (en) | 2012-12-21 | 2020-06-30 | 珀金埃尔默健康科学有限公司 | Low elasticity membranes for microfluidic applications |
US20150346097A1 (en) | 2012-12-21 | 2015-12-03 | Micronics, Inc. | Portable fluorescence detection system and microassay cartridge |
AU2014204411B2 (en) | 2013-01-07 | 2017-11-02 | Genea Ip Holdings Pty Limited | Method, system and apparatus for improved micromanipulation and storage |
US20150352752A1 (en) * | 2013-01-16 | 2015-12-10 | General Electric Company | An aqueous -solvent based process for continuous manufacturing of supported ion selective membranes |
KR102207127B1 (en) | 2013-02-01 | 2021-01-22 | 스와겔로크 컴패니 | Diaphragm valve with welded diaphragm seat carrier |
DE102013202623A1 (en) * | 2013-02-19 | 2014-08-21 | Robert Bosch Gmbh | Valve with improved cold start capability |
WO2014168711A1 (en) | 2013-03-13 | 2014-10-16 | Sequenom, Inc. | Primers for dna methylation analysis |
US9163277B2 (en) | 2013-03-14 | 2015-10-20 | Formulatrix, Inc. | Microfluidic device |
US9039993B2 (en) | 2013-03-14 | 2015-05-26 | Formulatrix, Inc. | Microfluidic device |
EP2970849B1 (en) | 2013-03-15 | 2019-08-21 | Fluidigm Corporation | Methods and devices for analysis of defined multicellular combinations |
US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
US9592151B2 (en) | 2013-03-15 | 2017-03-14 | Glaukos Corporation | Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye |
US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
CA2911308C (en) | 2013-05-07 | 2021-10-19 | Micronics, Inc. | Device for preparation and analysis of nucleic acids |
EP2994750B1 (en) | 2013-05-07 | 2020-08-12 | PerkinElmer Health Sciences, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
CN105189750B (en) | 2013-05-07 | 2020-07-28 | 珀金埃尔默健康科学有限公司 | Method for preparing nucleic acid-containing sample using clay mineral and alkaline solution |
ITTO20130447A1 (en) * | 2013-05-31 | 2014-12-01 | St Microelectronics Srl | MICROFLUID MEMBRANE VALVE AND PROCEDURE FOR MANUFACTURING A MEMBRANE MICROFLUID VALVE |
EP3039174B1 (en) | 2013-08-28 | 2019-10-16 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
WO2015050998A2 (en) | 2013-10-01 | 2015-04-09 | The Broad Institute, Inc. | Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US10136636B2 (en) | 2013-10-15 | 2018-11-27 | The Regents Of The University Of Michigan | Vitrification of biological material |
SG10202006525PA (en) | 2013-10-22 | 2020-08-28 | Berkeley Lights Inc | Microfluidic devices having isolation pens and methods of testing biological micro-objects with same |
US9889445B2 (en) | 2013-10-22 | 2018-02-13 | Berkeley Lights, Inc. | Micro-fluidic devices for assaying biological activity |
US9617145B2 (en) | 2013-10-22 | 2017-04-11 | Berkeley Lights, Inc. | Exporting a selected group of micro-objects from a micro-fluidic device |
CN105873681B (en) | 2013-11-18 | 2019-10-11 | 尹特根埃克斯有限公司 | Cartridge and instrument for sample analysis |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
US10344753B2 (en) | 2014-02-28 | 2019-07-09 | Encite Llc | Micro pump systems |
US11365447B2 (en) | 2014-03-13 | 2022-06-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10300484B2 (en) | 2014-03-26 | 2019-05-28 | The George Washington University | Handheld fluid handling systems and methods |
WO2015179098A1 (en) | 2014-05-21 | 2015-11-26 | Integenx Inc. | Fluidic cartridge with valve mechanism |
AU2015266850B2 (en) | 2014-05-29 | 2019-12-05 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
US10081816B1 (en) | 2014-07-03 | 2018-09-25 | Nant Holdings Ip, Llc | Mechanical transfection devices and methods |
US10760040B1 (en) * | 2014-07-03 | 2020-09-01 | NanoCav, LLC | Mechanical transfection devices and methods |
EP3209410A4 (en) | 2014-10-22 | 2018-05-02 | IntegenX Inc. | Systems and methods for sample preparation, processing and analysis |
US10330095B2 (en) * | 2014-10-31 | 2019-06-25 | Encite Llc | Microelectromechanical systems fabricated with roll to roll processing |
WO2016094333A1 (en) * | 2014-12-08 | 2016-06-16 | Berkeley Lights, Inc. | Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof |
US10578630B2 (en) * | 2014-12-09 | 2020-03-03 | Berkeley Lights, Inc. | Automated identification of assay areas in a microfluidic device and detection of assay positive areas based on rate of change of image light intensity |
US20180066262A1 (en) | 2015-03-09 | 2018-03-08 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
US10101250B2 (en) | 2015-04-22 | 2018-10-16 | Berkeley Lights, Inc. | Manipulation of cell nuclei in a micro-fluidic device |
US10723988B2 (en) | 2015-04-22 | 2020-07-28 | Berkeley Lights, Inc. | Microfluidic cell culture |
NL2014801B1 (en) * | 2015-05-13 | 2017-01-27 | Berkin Bv | Fluid flow device, comprising a valve unit, as well as method of manufacturing the same. |
US10136563B2 (en) | 2015-06-25 | 2018-11-20 | International Business Machines Corporation | Active perforation for advanced server cooling |
US9907210B2 (en) * | 2015-06-25 | 2018-02-27 | International Business Machines Corporation | Active perforation for advanced server cooling |
WO2017004243A1 (en) | 2015-06-29 | 2017-01-05 | Caris Science, Inc. | Therapeutic oligonucleotides |
US9733239B2 (en) | 2015-07-24 | 2017-08-15 | HJ Science & Technology, Inc. | Reconfigurable microfluidic systems: scalable, multiplexed immunoassays |
US9956558B2 (en) | 2015-07-24 | 2018-05-01 | HJ Science & Technology, Inc. | Reconfigurable microfluidic systems: homogeneous assays |
US9956557B2 (en) | 2015-07-24 | 2018-05-01 | HJ Science & Technology, Inc. | Reconfigurable microfluidic systems: microwell plate interface |
EP3328873A4 (en) | 2015-07-28 | 2019-04-10 | Caris Science, Inc. | Targeted oligonucleotides |
WO2017040856A1 (en) * | 2015-09-01 | 2017-03-09 | The Regents Of The Univesity Of California | Reconfigurable microvalve optical waveguide |
WO2017040853A1 (en) | 2015-09-02 | 2017-03-09 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
US10598166B2 (en) | 2015-09-09 | 2020-03-24 | Massachusetts Institute Of Technology | Atherofluidics-on-chip |
US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
US10799865B2 (en) | 2015-10-27 | 2020-10-13 | Berkeley Lights, Inc. | Microfluidic apparatus having an optimized electrowetting surface and related systems and methods |
EP3380238A1 (en) | 2015-11-23 | 2018-10-03 | Berkeley Lights, Inc. | In situ-generated microfluidic isolation structures, kits and methods of use thereof |
CN105258738B (en) * | 2015-11-26 | 2018-01-30 | 黑龙江大学 | A kind of pressure/two-dimensional magnetic field monolithic integrated sensor |
US10203604B2 (en) * | 2015-11-30 | 2019-02-12 | Applied Materials, Inc. | Method and apparatus for post exposure processing of photoresist wafers |
US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
CN114878807A (en) | 2015-12-08 | 2022-08-09 | 伯克利之光生命科技公司 | Microfluidic devices and kits and methods of use thereof |
CN108698814A (en) | 2015-12-30 | 2018-10-23 | 伯克利之光生命科技公司 | Microfluidic device, kit and its method of convection current and displacement for optical drive |
EP3313978B1 (en) | 2016-01-08 | 2024-02-28 | Hewlett-Packard Development Company, L.P. | Polymerase chain reaction device |
CN105510101B (en) * | 2016-01-28 | 2018-02-13 | 哈尔滨理工大学 | A kind of preparation method and sheet specimens for being used to study the sample of dry-type air-core reactor turn-to-turn insulation ageing process |
WO2017160991A1 (en) | 2016-03-16 | 2017-09-21 | Lavieu Gregory G | Methods, systems and devices for selection and generation of genome edited clones |
SG11201808022WA (en) | 2016-03-17 | 2018-10-30 | Berkeley Lights Inc | Selection and cloning of t lymphocytes in a microfluidic device |
CA3018066A1 (en) | 2016-03-18 | 2017-09-21 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
KR102038116B1 (en) * | 2016-03-21 | 2019-12-02 | 주식회사 엘지화학 | Protection film for flexible display |
AU2017248822B2 (en) | 2016-04-15 | 2022-09-15 | Berkeley Lights, Inc. | Methods, systems and kits for in-pen assays |
AU2017252294B2 (en) | 2016-04-20 | 2021-12-02 | Dose Medical Corporation | Bioresorbable ocular drug delivery device |
US11293017B2 (en) | 2016-05-25 | 2022-04-05 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
SG10202008265XA (en) | 2016-05-26 | 2020-09-29 | Berkeley Lights Inc | Covalently modified surfaces, kits, and methods of preparation and use |
EP3494376B1 (en) * | 2016-08-05 | 2021-06-09 | Marsh, Stephen Alan | Micro pressure sensor |
EP3496787B1 (en) | 2016-08-14 | 2020-07-08 | Insulet Corporation | Drug delivery device with detection of position of the plunger |
US11872559B2 (en) | 2016-09-14 | 2024-01-16 | Ecole Polytechnique Federale De Lausanne (Epfl) | Device for high throughput single-cell studies |
EP3522951A1 (en) | 2016-10-07 | 2019-08-14 | Insulet Corporation | Multi-stage delivery system |
US10780217B2 (en) | 2016-11-10 | 2020-09-22 | Insulet Corporation | Ratchet drive for on body delivery system |
CN106767551A (en) * | 2016-11-18 | 2017-05-31 | 合肥工业大学 | The preparation method that a kind of micro-nano measuring apparatus use the highly sensitive elastic spring of high accuracy |
AT15707U1 (en) | 2016-11-18 | 2018-04-15 | Secop Gmbh | REFRIGERANT COMPRESSOR |
US10767742B2 (en) * | 2016-12-08 | 2020-09-08 | Ford Global Technologies, Llc | Transaxle having chain final drive |
US10732712B2 (en) | 2016-12-27 | 2020-08-04 | Facebook Technologies, Llc | Large scale integration of haptic devices |
TWI621794B (en) * | 2017-01-05 | 2018-04-21 | 研能科技股份有限公司 | Fluid control device |
WO2018136699A1 (en) | 2017-01-19 | 2018-07-26 | Insulet Corporation | Cartridge hold-up volume reduction |
US10695485B2 (en) | 2017-03-07 | 2020-06-30 | Insulet Corporation | Very high volume user filled drug delivery device |
US11325125B2 (en) | 2017-04-23 | 2022-05-10 | Hewlett-Packard Development Company, L.P. | Particle separation |
WO2018213357A1 (en) * | 2017-05-16 | 2018-11-22 | Cairn Biosciences, Inc. | Microfluidic-enabled multiwell cell culture devices and systems for precision culture, control and monitoring of living cells |
EP3635412A4 (en) | 2017-06-06 | 2021-03-10 | The Regents of The University of California | Systems and methods for rapid generation of droplet libraries |
US10973978B2 (en) | 2017-08-03 | 2021-04-13 | Insulet Corporation | Fluid flow regulation arrangements for drug delivery devices |
WO2019028342A1 (en) | 2017-08-03 | 2019-02-07 | Insulet Corporation | Micro piston pump |
PL3665481T3 (en) | 2017-08-08 | 2024-02-05 | PPB Technology Pty Ltd | Carbohydrate sensors |
AU2018325527B2 (en) * | 2017-09-01 | 2021-09-16 | Mgi Tech Co., Ltd. | An injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor |
US11786668B2 (en) | 2017-09-25 | 2023-10-17 | Insulet Corporation | Drug delivery devices, systems, and methods with force transfer elements |
US11116625B2 (en) | 2017-09-28 | 2021-09-14 | Glaukos Corporation | Apparatus and method for controlling placement of intraocular implants |
EP3721209B1 (en) | 2017-10-15 | 2024-02-07 | Berkeley Lights, Inc. | Methods for in-pen assays |
US11046575B2 (en) | 2017-10-31 | 2021-06-29 | Encite Llc | Broad range micro pressure sensor |
US20190142111A1 (en) * | 2017-11-10 | 2019-05-16 | Head Technology Gmbh | Liner for sports shoes |
US11478790B2 (en) * | 2017-11-10 | 2022-10-25 | Nok Corporation | Microfluidic chip and microfluidic device |
WO2019103729A1 (en) * | 2017-11-22 | 2019-05-31 | Hewlett-Packard Development Company, L.P. | Microfluidic devices with lid for loading fluid |
WO2019116306A1 (en) | 2017-12-13 | 2019-06-20 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for capture or immunoprecipitation of a protein-dna complex |
US11154864B2 (en) | 2018-01-17 | 2021-10-26 | Qiagen Sciences, Llc | Microfluidic device with vented microchambers |
WO2019169060A1 (en) * | 2018-03-02 | 2019-09-06 | President And Fellows Of Harvard College | Layered microfluidic devices and techniques |
CA3091580A1 (en) * | 2018-03-02 | 2019-09-06 | National Research Council Of Canada | Polymeric microfluidic valve |
WO2019186569A1 (en) | 2018-03-29 | 2019-10-03 | Yeda Research And Development Co. Ltd. | Use of electric field gradients to control gene expression |
DE102018107585B3 (en) * | 2018-03-29 | 2019-03-28 | Universität Rostock | Device for producing 3D printed drug delivery systems with drug depots, and methods for manufacturing 3D printed drug delivery systems |
DE102018109314A1 (en) * | 2018-04-19 | 2019-10-24 | Eisenhuth Gmbh & Co. Kg | Electrochemical precipitation reactor with moving electrode |
EP3787795A4 (en) | 2018-04-30 | 2022-01-26 | Protein Fluidics, Inc. | Valveless fluidic switching flowchip and uses thereof |
US10874803B2 (en) | 2018-05-31 | 2020-12-29 | Insulet Corporation | Drug cartridge with drive system |
SG11202011180UA (en) | 2018-05-31 | 2020-12-30 | Berkeley Lights Inc | Automated detection and characterization of micro-objects in microfluidic devices |
US11229736B2 (en) | 2018-06-06 | 2022-01-25 | Insulet Corporation | Linear shuttle pump for drug delivery |
US11660389B2 (en) | 2018-07-17 | 2023-05-30 | Insulet Corporation | Semi-rigid and flexible elements for wearable drug delivery device reservoir |
US11815507B2 (en) | 2018-08-15 | 2023-11-14 | Deepcell, Inc. | Systems and methods for particle analysis |
US10611995B2 (en) | 2018-08-15 | 2020-04-07 | Deepcell, Inc. | Systems and methods for particle analysis |
CN108843855B (en) * | 2018-08-31 | 2024-03-12 | 湖南乐准智芯生物科技有限公司 | Microfluidic system, normally-closed micro valve and control method |
WO2020051529A1 (en) | 2018-09-07 | 2020-03-12 | Sequenom, Inc. | Methods, and systems to detect transplant rejection |
MX2020014071A (en) | 2018-11-16 | 2021-05-27 | Illumina Inc | Laminate fluidic circuit for a fluid cartridge. |
AU2019390474B2 (en) | 2018-11-28 | 2023-03-30 | Insulet Corporation | Drug delivery shuttle pump system and valve assembly |
MX2021006234A (en) | 2018-11-30 | 2021-09-10 | Caris Mpi Inc | Next-generation molecular profiling. |
CN109718875B (en) * | 2018-12-24 | 2021-08-24 | 东南大学 | Method for structurally integrating polyurethane film based on PDMS (polydimethylsiloxane) micro-fluid |
CA3128894A1 (en) | 2019-02-19 | 2020-08-27 | Sequenom, Inc. | Compositions, methods, and systems to detect hematopoietic stem cell transplantation status |
DE102019105191A1 (en) * | 2019-02-28 | 2020-09-03 | Prominent Gmbh | Positive displacement pump with surfaces that promote flow |
USD919833S1 (en) | 2019-03-06 | 2021-05-18 | Princeton Biochemicals, Inc | Micro valve for controlling path of fluids in miniaturized capillary connections |
CN114126762B (en) | 2019-04-30 | 2023-01-03 | 伯克利之光生命科技公司 | Methods for encapsulating and assaying cells |
JP2022535922A (en) | 2019-06-25 | 2022-08-10 | ヒューレット-パッカード デベロップメント カンパニー エル.ピー. | Molded structure with channels |
BR112022002365A2 (en) | 2019-08-09 | 2022-04-26 | Nutcracker Therapeutics Inc | Methods and apparatus for making and removing material from a therapeutic composition |
IL269674B (en) | 2019-09-25 | 2020-08-31 | Roy Bar Ziv | Assembly of protein complexes on a chip |
JP2022552194A (en) | 2019-10-10 | 2022-12-15 | 1859,インク. | Methods and systems for microfluidic screening |
CN110586216A (en) * | 2019-10-16 | 2019-12-20 | 陕西优博特生物科技有限公司 | Sample sampling system for micro-current control chip experiment |
US11369735B2 (en) | 2019-11-05 | 2022-06-28 | Insulet Corporation | Component positioning of a linear shuttle pump |
US11744561B2 (en) | 2019-11-07 | 2023-09-05 | Smylio Inc. | Saliva collection and testing system |
JP2023503253A (en) | 2019-11-17 | 2023-01-27 | バークレー ライツ,インコーポレイテッド | Systems and methods for analyzing biological samples |
JP2023504270A (en) | 2019-12-02 | 2023-02-02 | カリス エムピーアイ インコーポレイテッド | A pan-cancer platinum response predictor |
EP3845790A1 (en) * | 2019-12-30 | 2021-07-07 | Imec VZW | Microfluidic device for controlling pneumatic microvalves |
EP4090464A1 (en) | 2020-01-17 | 2022-11-23 | F. Hoffmann-La Roche AG | Microfluidic device and method for automated split-pool synthesis |
WO2021148488A2 (en) | 2020-01-22 | 2021-07-29 | F. Hoffmann-La Roche Ag | Microfluidic bead trapping devices and methods for next generation sequencing library preparation |
US20230120825A1 (en) | 2020-02-28 | 2023-04-20 | Laboratory Corporation Of America Holdings | Compositions, Methods, and Systems for Paternity Determination |
JP2022000611A (en) * | 2020-06-19 | 2022-01-04 | シスメックス株式会社 | Particle sorter, particle sorting method and micro flow passage cartridge |
US11872357B2 (en) | 2020-11-09 | 2024-01-16 | Agile Devices, Inc. | Devices for steering catheters |
CN112452365B (en) * | 2020-11-23 | 2021-12-07 | 无锡市夸克微智造科技有限责任公司 | Micro-machining fluid device |
WO2023035003A1 (en) | 2021-09-03 | 2023-03-09 | Elegen Corp. | Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources |
DE102022107894A1 (en) * | 2022-04-01 | 2023-10-05 | Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts | Method of manufacturing a reactor, reactors and assemblies |
WO2023196802A1 (en) | 2022-04-04 | 2023-10-12 | The Broad Institute, Inc. | Cas9 variants having non-canonical pam specificities and uses thereof |
WO2023238132A1 (en) | 2022-06-07 | 2023-12-14 | Yeda Research And Development Co. Ltd. | Microfluidic device for analyzing steady state biological reactions |
ES2958141A1 (en) * | 2022-07-07 | 2024-02-02 | Univ Madrid Carlos Iii | SELF-HEALING CONDUCTIVE MATERIAL |
CN115445678B (en) * | 2022-08-23 | 2023-08-01 | 电子科技大学 | Method, device and application for driving magnetic fluid to horizontally move |
Family Cites Families (220)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US141503A (en) | 1873-08-05 | Improvement in treating cotton-seed oil to render it drying | ||
US409832A (en) * | 1889-08-27 | Compound fire-proof column | ||
US147199A (en) | 1874-02-03 | Improvement in revolving horse hay-rakes | ||
US186856A (en) | 1877-01-30 | Improvement in sheet-metal cans | ||
US499312A (en) * | 1893-06-13 | Alonzo g | ||
US2260938A (en) * | 1940-06-24 | 1941-10-28 | Standard Railway Equipment Mfg | Hatch construction |
US2620938A (en) | 1949-09-02 | 1952-12-09 | Package Devices Inc | Container closure |
US3495608A (en) | 1967-05-04 | 1970-02-17 | Pitney Bowes Inc | Fluidic elements and devices thereof |
US3570515A (en) | 1969-06-19 | 1971-03-16 | Foxboro Co | Aminar stream cross-flow fluid diffusion logic gate |
GB1362952A (en) | 1970-07-21 | 1974-08-07 | Rasmussen O B | Conjugate fibre and method of manufacturing same |
NL7102074A (en) | 1971-02-17 | 1972-08-21 | ||
DE2138491B1 (en) * | 1971-07-31 | 1973-02-15 | Hoffman-Rheem Maschinen Gmbh, 5000 Koeln | Hand steam and ironing plate |
GB1520402A (en) * | 1974-07-30 | 1978-08-09 | Mitsubishi Electric Corp | Combustion apparatus |
FR2287606A1 (en) | 1974-10-08 | 1976-05-07 | Pegourie Jean Pierre | PNEUMATIC LOGIC CIRCUITS AND THEIR INTEGRATED CIRCUITS |
JPS5941169B2 (en) * | 1975-12-25 | 1984-10-05 | シチズン時計株式会社 | Elastomer |
US4153655A (en) * | 1976-07-23 | 1979-05-08 | Minnick Leonard J | Products from molten fly ash and scrubber sludge including fly ash |
US4153855A (en) | 1977-12-16 | 1979-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method of making a plate having a pattern of microchannels |
US4245673A (en) | 1978-03-01 | 1981-01-20 | La Telemechanique Electrique | Pneumatic logic circuit |
US4434704A (en) | 1980-04-14 | 1984-03-06 | Halliburton Company | Hydraulic digital stepper actuator |
US4581624A (en) * | 1984-03-01 | 1986-04-08 | Allied Corporation | Microminiature semiconductor valve |
US5088515A (en) | 1989-05-01 | 1992-02-18 | Kamen Dean L | Valve system with removable fluid interface |
DE3882011T2 (en) | 1987-10-27 | 1993-09-30 | Fujitsu Ltd | Method and device for producing biopolymer single crystal. |
US4848722A (en) | 1987-12-11 | 1989-07-18 | Integrated Fluidics, Inc. | Valve with flexible sheet member |
US4852851A (en) * | 1987-12-11 | 1989-08-01 | Integrated Fluidics, Inc. | Valve with flexible sheet member |
US4898582A (en) | 1988-08-09 | 1990-02-06 | Pharmetrix Corporation | Portable infusion device assembly |
DE3889119T3 (en) | 1988-12-20 | 1998-01-15 | Du Pont | Polyester resin filled with low adhesion glass fibers. |
US4992312A (en) | 1989-03-13 | 1991-02-12 | Dow Corning Wright Corporation | Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby |
CH679555A5 (en) | 1989-04-11 | 1992-03-13 | Westonbridge Int Ltd | |
DE3917396A1 (en) | 1989-05-29 | 1990-12-06 | Buerkert Gmbh | MICRO VALVE |
CA2033181C (en) | 1989-06-14 | 2000-10-24 | Harald T. G. Van Lintel | Two valve micropump with improved outlet |
US5238223A (en) * | 1989-08-11 | 1993-08-24 | Robert Bosch Gmbh | Method of making a microvalve |
JP2555193B2 (en) | 1989-08-22 | 1996-11-20 | ファナック株式会社 | Oldham fittings |
US5171132A (en) | 1989-12-27 | 1992-12-15 | Seiko Epson Corporation | Two-valve thin plate micropump |
DE4006152A1 (en) | 1990-02-27 | 1991-08-29 | Fraunhofer Ges Forschung | MICROMINIATURIZED PUMP |
US6054034A (en) * | 1990-02-28 | 2000-04-25 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
US5096388A (en) | 1990-03-22 | 1992-03-17 | The Charles Stark Draper Laboratory, Inc. | Microfabricated pump |
US5429856A (en) | 1990-03-30 | 1995-07-04 | Minnesota Mining And Manufacturing Company | Composite materials and process |
SE470347B (en) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Microstructure for fluid flow systems and process for manufacturing such a system |
EP0465229B1 (en) | 1990-07-02 | 1994-12-28 | Seiko Epson Corporation | Micropump and process for manufacturing a micropump |
US5108682A (en) | 1990-07-24 | 1992-04-28 | Bridgestone/Firestone, Inc. | Coextrusion apparatus and method using an elastic die for varying the outer profile of a tubular extrudate |
US5164558A (en) | 1991-07-05 | 1992-11-17 | Massachusetts Institute Of Technology | Micromachined threshold pressure switch and method of manufacture |
JP3328300B2 (en) | 1991-07-18 | 2002-09-24 | アイシン精機株式会社 | Fluid control device |
DE4135655A1 (en) | 1991-09-11 | 1993-03-18 | Fraunhofer Ges Forschung | MICROMINIATURIZED, ELECTROSTATICALLY OPERATED DIAPHRAGM PUMP |
US5265327A (en) | 1991-09-13 | 1993-11-30 | Faris Sadeg M | Microchannel plate technology |
US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5637469A (en) | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
DE4220077A1 (en) | 1992-06-19 | 1993-12-23 | Bosch Gmbh Robert | Micro-pump for delivery of gases - uses working chamber warmed by heating element and controlled by silicon wafer valves. |
US5364742A (en) * | 1992-09-21 | 1994-11-15 | International Business Machines Corporation | Micro-miniature structures and method of fabrication thereof |
JP2812629B2 (en) | 1992-11-25 | 1998-10-22 | 宇宙開発事業団 | Crystal growth cell |
US5290240A (en) | 1993-02-03 | 1994-03-01 | Pharmetrix Corporation | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid |
US5670102A (en) | 1993-02-11 | 1997-09-23 | Minnesota Mining And Manufacturing Company | Method of making thermoplastic foamed articles using supercritical fluid |
US5387329A (en) | 1993-04-09 | 1995-02-07 | Ciba Corning Diagnostics Corp. | Extended use planar sensors |
WO1994028318A1 (en) | 1993-05-27 | 1994-12-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Microvalve |
US5400741A (en) | 1993-05-21 | 1995-03-28 | Medical Foundation Of Buffalo, Inc. | Device for growing crystals |
SE501713C2 (en) * | 1993-09-06 | 1995-05-02 | Pharmacia Biosensor Ab | Diaphragm-type valve, especially for liquid handling blocks with micro-flow channels |
US5642015A (en) * | 1993-07-14 | 1997-06-24 | The University Of British Columbia | Elastomeric micro electro mechanical systems |
US5417235A (en) * | 1993-07-28 | 1995-05-23 | Regents Of The University Of Michigan | Integrated microvalve structures with monolithic microflow controller |
US5659171A (en) | 1993-09-22 | 1997-08-19 | Northrop Grumman Corporation | Micro-miniature diaphragm pump for the low pressure pumping of gases |
DE4332720C2 (en) | 1993-09-25 | 1997-02-13 | Karlsruhe Forschzent | Micro diaphragm pump |
US5423267A (en) * | 1993-12-30 | 1995-06-13 | Eklund; Byron G. | Pocket rerailer |
CH689836A5 (en) | 1994-01-14 | 1999-12-15 | Westonbridge Int Ltd | Micropump. |
US5538223A (en) * | 1994-04-21 | 1996-07-23 | Scace; Gregory | Single line multiple purchase block and tackle system |
US5472053A (en) * | 1994-09-14 | 1995-12-05 | Halliburton Company | Leakproof floating apparatus and method for fabricating said apparatus |
DE4433894A1 (en) * | 1994-09-22 | 1996-03-28 | Fraunhofer Ges Forschung | Method and device for controlling a micropump |
EP0706004B1 (en) * | 1994-10-07 | 2003-08-06 | Bayer Corporation | Relief valve |
US5571410A (en) * | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
US5788468A (en) | 1994-11-03 | 1998-08-04 | Memstek Products, Llc | Microfabricated fluidic devices |
EP0791238B1 (en) | 1994-11-10 | 2004-09-22 | Orchid BioSciences, Inc. | Liquid distribution system |
JP3094880B2 (en) | 1995-03-01 | 2000-10-03 | 住友金属工業株式会社 | Method for controlling crystallization of organic compound and solid state element for controlling crystallization used therein |
US5775371A (en) | 1995-03-08 | 1998-07-07 | Abbott Laboratories | Valve control |
US5876187A (en) | 1995-03-09 | 1999-03-02 | University Of Washington | Micropumps with fixed valves |
US6168948B1 (en) * | 1995-06-29 | 2001-01-02 | Affymetrix, Inc. | Miniaturized genetic analysis systems and methods |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
CA2183478C (en) | 1995-08-17 | 2004-02-24 | Stephen A. Carter | Digital gas metering system using tri-stable and bi-stable solenoids |
US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
US5598033A (en) | 1995-10-16 | 1997-01-28 | Advanced Micro Devices, Inc. | Micro BGA stacking scheme |
US5958344A (en) | 1995-11-09 | 1999-09-28 | Sarnoff Corporation | System for liquid distribution |
US5705018A (en) | 1995-12-13 | 1998-01-06 | Hartley; Frank T. | Micromachined peristaltic pump |
KR100207410B1 (en) * | 1995-12-19 | 1999-07-15 | 전주범 | Fabrication method for lightpath modulation device |
US5660370A (en) * | 1996-03-07 | 1997-08-26 | Integrated Fludics, Inc. | Valve with flexible sheet member and two port non-flexing backer member |
US5724677A (en) | 1996-03-08 | 1998-03-10 | Minnesota Mining And Manufacturing Company | Multi-part headband and respirator mask assembly and process for making same |
US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
US5810325A (en) | 1996-06-25 | 1998-09-22 | Bcam International, Inc. | Microvalve |
US5779868A (en) | 1996-06-28 | 1998-07-14 | Caliper Technologies Corporation | Electropipettor and compensation means for electrophoretic bias |
CA2259395C (en) | 1996-07-15 | 2002-03-05 | Sumitomo Metal Industries, Ltd. | Equipment for crystal growth and crystal-growing method using the same |
US5876157A (en) * | 1996-07-17 | 1999-03-02 | Wethered; William | Drill centering jig and forming tool guide |
US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
US5738799A (en) * | 1996-09-12 | 1998-04-14 | Xerox Corporation | Method and materials for fabricating an ink-jet printhead |
US5788488A (en) * | 1996-09-23 | 1998-08-04 | Precision Dental International, Inc. | Dental reamer stop dispenser |
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US5865417A (en) | 1996-09-27 | 1999-02-02 | Redwood Microsystems, Inc. | Integrated electrically operable normally closed valve |
US5839722A (en) * | 1996-11-26 | 1998-11-24 | Xerox Corporation | Paper handling system having embedded control structures |
US6123316A (en) * | 1996-11-27 | 2000-09-26 | Xerox Corporation | Conduit system for a valve array |
US5971355A (en) | 1996-11-27 | 1999-10-26 | Xerox Corporation | Microdevice valve structures to fluid control |
FR2757906A1 (en) * | 1996-12-31 | 1998-07-03 | Westonbridge Int Ltd | MICROPUMP WITH INTEGRATED INTERMEDIATE PART |
US6436529B1 (en) | 1997-01-21 | 2002-08-20 | 3M Innovative Properties Company | Elatomeric laminates and composites |
US6376971B1 (en) * | 1997-02-07 | 2002-04-23 | Sri International | Electroactive polymer electrodes |
US5882496A (en) * | 1997-02-27 | 1999-03-16 | The Regents Of The University Of California | Porous silicon structures with high surface area/specific pore size |
US6069392A (en) | 1997-04-11 | 2000-05-30 | California Institute Of Technology | Microbellows actuator |
US6116863A (en) * | 1997-05-30 | 2000-09-12 | University Of Cincinnati | Electromagnetically driven microactuated device and method of making the same |
US5922604A (en) | 1997-06-05 | 1999-07-13 | Gene Tec Corporation | Thin reaction chambers for containing and handling liquid microvolumes |
US6304364B1 (en) | 1997-06-11 | 2001-10-16 | President & Fellows Of Harvard College | Elastomeric light valves |
EP0991928A2 (en) | 1997-06-27 | 2000-04-12 | Immunetics | Rapid flow-through binding assay apparatus and method |
WO1999004361A1 (en) | 1997-07-16 | 1999-01-28 | Diversified Scientific, Inc. | Method for acquiring, storing and analyzing crystal images |
US6073482A (en) | 1997-07-21 | 2000-06-13 | Ysi Incorporated | Fluid flow module |
US5932799A (en) * | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
US5876675A (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
US5965410A (en) | 1997-09-02 | 1999-10-12 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
US5999307A (en) | 1997-09-04 | 1999-12-07 | The University Of British Columbia | Method and apparatus for controllable frustration of total internal reflection |
US20020092767A1 (en) * | 1997-09-19 | 2002-07-18 | Aclara Biosciences, Inc. | Multiple array microfluidic device units |
US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
US7214298B2 (en) | 1997-09-23 | 2007-05-08 | California Institute Of Technology | Microfabricated cell sorter |
US6833242B2 (en) | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
US5836750A (en) | 1997-10-09 | 1998-11-17 | Honeywell Inc. | Electrostatically actuated mesopump having a plurality of elementary cells |
US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US5958694A (en) | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
AU1522299A (en) * | 1997-11-12 | 1999-05-31 | California Institute Of Technology | Micromachined parylene membrane valve and pump |
US6174675B1 (en) | 1997-11-25 | 2001-01-16 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
US6155282A (en) | 1998-01-20 | 2000-12-05 | Triconex, Incorporated | Two out of three voting solenoid arrangement |
US6790526B2 (en) * | 1998-01-30 | 2004-09-14 | Integument Technologies, Inc. | Oxyhalopolymer protective multifunctional appliqués and paint replacement films |
US6451674B1 (en) * | 1998-02-18 | 2002-09-17 | Matsushita Electronics Corporation | Method for introducing impurity into a semiconductor substrate without negative charge buildup phenomenon |
US6376619B1 (en) | 1998-04-13 | 2002-04-23 | 3M Innovative Properties Company | High density, miniaturized arrays and methods of manufacturing same |
AU3491299A (en) | 1998-04-14 | 1999-11-01 | Lumenal Technologies, L.P. | Test cartridge with a single inlet port |
AU4719399A (en) | 1998-06-26 | 2000-01-17 | University Of Washington | Crystallization media |
US6225243B1 (en) | 1998-08-03 | 2001-05-01 | Bba Nonwovens Simpsonville, Inc. | Elastic nonwoven fabric prepared from bi-component filaments |
US6221483B1 (en) | 1998-09-10 | 2001-04-24 | Avery Dennison Corporation | Reversibly extensible film |
US6482306B1 (en) * | 1998-09-22 | 2002-11-19 | University Of Washington | Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer |
RU2143343C1 (en) | 1998-11-03 | 1999-12-27 | Самсунг Электроникс Ко., Лтд. | Microinjector and microinjector manufacture method |
US6958865B1 (en) | 1998-11-12 | 2005-10-25 | California Institute Of Technology | Microlicensing particles and applications |
CA2350595A1 (en) | 1998-11-16 | 2000-05-25 | California Institute Of Technology | Parylene micro check valve and fabrication method thereof |
AU3508600A (en) * | 1999-02-26 | 2000-09-14 | Orchid Biosciences, Inc. | Microstructures for use in biological assays and reactions |
JP2000314381A (en) * | 1999-03-03 | 2000-11-14 | Ngk Insulators Ltd | Pump |
ATE357656T1 (en) | 1999-04-06 | 2007-04-15 | Univ Alabama Res Found | DEVICE FOR SCREENING CRYSTALIZATION CONDITIONS IN CRYSTAL GROWING SOLUTIONS |
US20030129654A1 (en) * | 1999-04-15 | 2003-07-10 | Ilya Ravkin | Coded particles for multiplexed analysis of biological samples |
US6406605B1 (en) * | 1999-06-01 | 2002-06-18 | Ysi Incorporated | Electroosmotic flow controlled microfluidic devices |
US6296673B1 (en) | 1999-06-18 | 2001-10-02 | The Regents Of The University Of California | Methods and apparatus for performing array microcrystallizations |
EP2309130B1 (en) | 1999-06-28 | 2016-08-10 | California Institute of Technology | Microfabricated elastomeric valve and pump systems |
US7144616B1 (en) | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US6929030B2 (en) | 1999-06-28 | 2005-08-16 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
US6899137B2 (en) | 1999-06-28 | 2005-05-31 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
WO2001006575A1 (en) | 1999-07-20 | 2001-01-25 | Sri International | Improved electroactive polymers |
AU6396500A (en) | 1999-08-02 | 2001-02-19 | Emerald Biostructures, Inc. | Method and system for creating a crystallization results database |
US7255506B2 (en) * | 2000-06-02 | 2007-08-14 | The Procter & Gamble Company | Semi-enclosed applicator for distributing a substance onto a target surface |
US20020112961A1 (en) * | 1999-12-02 | 2002-08-22 | Nanostream, Inc. | Multi-layer microfluidic device fabrication |
US20020012926A1 (en) | 2000-03-03 | 2002-01-31 | Mycometrix, Inc. | Combinatorial array for nucleic acid analysis |
JP4927287B2 (en) | 2000-03-31 | 2012-05-09 | マイクロニックス、インコーポレーテッド | Microfluidic device for protein crystallization |
US20050118073A1 (en) | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
JP2003533682A (en) * | 2000-05-15 | 2003-11-11 | テカン・トレーディング・アクチェンゲゼルシャフト | Bidirectional flow centrifugal microfluidic device |
US6431212B1 (en) * | 2000-05-24 | 2002-08-13 | Jon W. Hayenga | Valve for use in microfluidic structures |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
AU2001273057A1 (en) | 2000-06-27 | 2002-01-08 | Fluidigm Corporation | A microfluidic design automation method and system |
US6885982B2 (en) | 2000-06-27 | 2005-04-26 | Fluidigm Corporation | Object oriented microfluidic design method and system |
US6301055B1 (en) | 2000-08-16 | 2001-10-09 | California Institute Of Technology | Solid immersion lens structures and methods for producing solid immersion lens structures |
AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
US7097809B2 (en) | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
EP1322936A2 (en) | 2000-10-03 | 2003-07-02 | California Institute Of Technology | Microfluidic devices and methods of use |
US7678547B2 (en) | 2000-10-03 | 2010-03-16 | California Institute Of Technology | Velocity independent analyte characterization |
US6508988B1 (en) | 2000-10-03 | 2003-01-21 | California Institute Of Technology | Combinatorial synthesis system |
EP1336097A4 (en) | 2000-10-13 | 2006-02-01 | Fluidigm Corp | Microfluidic device based sample injection system for analytical devices |
WO2002065005A1 (en) | 2000-11-06 | 2002-08-22 | California Institute Of Technology | Electrostatic valves for microfluidic devices |
AU2002248149A1 (en) | 2000-11-16 | 2002-08-12 | Fluidigm Corporation | Microfluidic devices for introducing and dispensing fluids from microfluidic systems |
US7378280B2 (en) | 2000-11-16 | 2008-05-27 | California Institute Of Technology | Apparatus and methods for conducting assays and high throughput screening |
US6752922B2 (en) | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
ATE500051T1 (en) | 2001-04-06 | 2011-03-15 | Fluidigm Corp | POLYMER SURFACE MODIFICATION |
EP1384022A4 (en) | 2001-04-06 | 2004-08-04 | California Inst Of Techn | Nucleic acid amplification utilizing microfluidic devices |
US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
US7075162B2 (en) | 2001-08-30 | 2006-07-11 | Fluidigm Corporation | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes |
EP1434685A1 (en) | 2001-10-08 | 2004-07-07 | California Institute Of Technology | Microfabricated lenses, methods of manufacture thereof, and applications therefor |
US7192629B2 (en) | 2001-10-11 | 2007-03-20 | California Institute Of Technology | Devices utilizing self-assembled gel and method of manufacture |
AU2002351187A1 (en) | 2001-11-30 | 2003-06-17 | Fluidigm Corporation | Microfluidic device and methods of using same |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
CA2480728A1 (en) | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US7059348B2 (en) | 2002-05-13 | 2006-06-13 | Fluidigm Corporation | Drug delivery system |
US20060086309A1 (en) | 2002-06-24 | 2006-04-27 | Fluiding Corporation | Recirculating fluidic network and methods for using the same |
JP2006501056A (en) | 2002-09-25 | 2006-01-12 | カリフォルニア インスティテュート オブ テクノロジー | Micro fluid large scale integration |
EP1546412B1 (en) | 2002-10-02 | 2014-05-21 | California Institute Of Technology | Microfluidic nucleic acid analysis |
GB0302302D0 (en) | 2003-01-31 | 2003-03-05 | Glaxo Group Ltd | Microfluidic apparatus and method |
US7476363B2 (en) | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
EP2340890B1 (en) | 2003-04-03 | 2016-10-19 | Fluidigm Corporation | Method of performimg digital PCR |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
WO2004094020A2 (en) | 2003-04-17 | 2004-11-04 | Fluidigm Corporation | Crystal growth devices and systems, and methods for using same |
EP1636017A2 (en) | 2003-05-20 | 2006-03-22 | Fluidigm Corporation | Method and system for microfluidic device and imaging thereof |
US7583853B2 (en) | 2003-07-28 | 2009-09-01 | Fluidigm Corporation | Image processing method and system for microfluidic devices |
US7042649B2 (en) | 2003-08-11 | 2006-05-09 | California Institute Of Technology | Microfabricated rubber microscope using soft solid immersion lenses |
US7413712B2 (en) | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
US20060172408A1 (en) | 2003-12-01 | 2006-08-03 | Quake Steven R | Device for immobilizing chemical and biochemical species and methods of using same |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
US7307802B2 (en) | 2004-06-07 | 2007-12-11 | Fluidigm Corporation | Optical lens system and method for microfluidic devices |
DE602005004410T2 (en) * | 2004-07-07 | 2009-01-08 | Philips Intellectual Property & Standards Gmbh | SYSTEM AND METHOD FOR CORRECTING TEMPORARY ARTEFACT IN TOMOGRAPHIC IMAGES |
US20080264863A1 (en) | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
JP2008522795A (en) | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | Microfluidic device with chemical reaction circuit |
US7883669B2 (en) | 2005-04-20 | 2011-02-08 | Fluidigm Corporation | Analysis engine and database for manipulating parameters for fluidic systems on a chip |
US20090317798A1 (en) | 2005-06-02 | 2009-12-24 | Heid Christian A | Analysis using microfluidic partitioning devices |
US20070048192A1 (en) * | 2005-08-10 | 2007-03-01 | Emil Kartalov | Integrated microfluidic vias, overpasses, underpasses, septums, microfuses, nested bioarrays and methods for fabricating the same |
US20070054293A1 (en) | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
EP1938101A2 (en) | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Microfluidic assay devices and methods |
US8206975B2 (en) | 2005-10-28 | 2012-06-26 | California Institute Of Technology | Method and device for regulating fluid flow in microfluidic devices |
WO2007089587A2 (en) | 2006-01-26 | 2007-08-09 | California Institute Of Technology | Mechanically induced trapping of molecular interactions |
US20070248971A1 (en) | 2006-01-26 | 2007-10-25 | California Institute Of Technology | Programming microfluidic devices with molecular information |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US8828661B2 (en) | 2006-04-24 | 2014-09-09 | Fluidigm Corporation | Methods for detection and quantification of nucleic acid or protein targets in a sample |
US8055034B2 (en) | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
WO2008043046A2 (en) | 2006-10-04 | 2008-04-10 | Fluidigm Corporation | Microfluidic check valves |
WO2008067552A2 (en) | 2006-11-30 | 2008-06-05 | Fluidigm Corporation | Method and apparatus for biological sample analysis |
EP2125219B1 (en) | 2007-01-19 | 2016-08-10 | Fluidigm Corporation | High precision microfluidic devices and methods |
US7974380B2 (en) | 2007-05-09 | 2011-07-05 | Fluidigm Corporation | Method and system for crystallization and X-ray diffraction screening |
CA2698545C (en) | 2007-09-07 | 2014-07-08 | Fluidigm Corporation | Copy number variation determination, methods and systems |
US9157116B2 (en) | 2008-02-08 | 2015-10-13 | Fluidigm Corporation | Combinatorial amplification and detection of nucleic acids |
US9487822B2 (en) | 2008-03-19 | 2016-11-08 | Fluidigm Corporation | Method and apparatus for determining copy number variation using digital PCR |
CN102165076B (en) | 2008-07-25 | 2014-07-09 | 弗卢丁公司 | Method and system for manufacturing integrated fluidic chips |
WO2010017210A1 (en) | 2008-08-07 | 2010-02-11 | Fluidigm Corporation | Microfluidic mixing and reaction systems for high efficiency screening |
EP2376227A4 (en) | 2008-12-08 | 2012-07-18 | Fluidigm Corp | Programmable microfluidic digital array |
US8058630B2 (en) | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
-
2000
- 2000-06-27 EP EP10180441.7A patent/EP2309130B1/en not_active Expired - Lifetime
- 2000-06-27 AT AT00943235T patent/ATE343724T1/en not_active IP Right Cessation
- 2000-06-27 CA CA2378190A patent/CA2378190C/en not_active Expired - Lifetime
- 2000-06-27 KR KR1020017016720A patent/KR100865105B1/en not_active IP Right Cessation
- 2000-06-27 EP EP00943235A patent/EP1194693B1/en not_active Expired - Lifetime
- 2000-06-27 AT AT00305389T patent/ATE215673T1/en active
- 2000-06-27 CN CNB008113009A patent/CN100402850C/en not_active Expired - Lifetime
- 2000-06-27 DK DK00305389T patent/DK1065378T3/en active
- 2000-06-27 CA CA 2721172 patent/CA2721172C/en not_active Expired - Lifetime
- 2000-06-27 US US09/605,520 patent/US7601270B1/en not_active Expired - Fee Related
- 2000-06-27 MX MXPA01012959A patent/MXPA01012959A/en active IP Right Grant
- 2000-06-27 ES ES00305389T patent/ES2174798T3/en not_active Expired - Lifetime
- 2000-06-27 DE DE2000618425 patent/DE60018425T2/en not_active Expired - Lifetime
- 2000-06-27 EP EP20000305389 patent/EP1065378B1/en not_active Expired - Lifetime
- 2000-06-27 AU AU57734/00A patent/AU779988B2/en not_active Expired
- 2000-06-27 DE DE2000600109 patent/DE60000109T2/en not_active Expired - Lifetime
- 2000-06-27 JP JP2001515901A patent/JP2003524738A/en active Pending
- 2000-06-27 NZ NZ533466A patent/NZ533466A/en not_active IP Right Cessation
- 2000-06-27 IL IL14730200A patent/IL147302A0/en active IP Right Grant
- 2000-06-27 AT AT01128819T patent/ATE290166T1/en not_active IP Right Cessation
- 2000-06-27 WO PCT/US2000/017740 patent/WO2001001025A2/en active IP Right Grant
- 2000-06-27 GB GB0015726A patent/GB2352283A/en not_active Withdrawn
- 2000-06-27 DE DE60031540T patent/DE60031540T2/en not_active Expired - Lifetime
- 2000-06-27 BR BRPI0011982-2A patent/BR0011982B1/en not_active IP Right Cessation
-
2001
- 2001-02-28 US US09/796,666 patent/US6408878B2/en not_active Expired - Lifetime
- 2001-02-28 US US09/796,871 patent/US7040338B2/en not_active Expired - Lifetime
- 2001-02-28 US US09/796,378 patent/US6793753B2/en not_active Expired - Lifetime
- 2001-12-20 NO NO20016268A patent/NO330662B1/en not_active IP Right Cessation
- 2001-12-25 IL IL147302A patent/IL147302A/en unknown
-
2002
- 2002-05-15 US US10/150,895 patent/US7169314B2/en not_active Expired - Fee Related
-
2004
- 2004-09-20 US US10/945,737 patent/US7494555B2/en not_active Expired - Fee Related
- 2004-09-24 JP JP2004278576A patent/JP2005096072A/en not_active Withdrawn
-
2005
- 2005-05-13 US US11/129,167 patent/US20050226742A1/en not_active Abandoned
- 2005-12-29 JP JP2005380631A patent/JP2006247830A/en active Pending
-
2006
- 2006-06-28 JP JP2006178847A patent/JP2006315174A/en not_active Withdrawn
-
2007
- 2007-11-01 US US11/933,998 patent/US8220487B2/en not_active Expired - Lifetime
- 2007-11-02 US US11/934,192 patent/US20080210320A1/en not_active Abandoned
- 2007-11-02 US US11/934,235 patent/US8002933B2/en not_active Expired - Fee Related
- 2007-11-02 US US11/934,212 patent/US20080210321A1/en not_active Abandoned
-
2008
- 2008-09-04 JP JP2008227637A patent/JP2009034814A/en active Pending
-
2009
- 2009-08-13 US US12/540,994 patent/US8104515B2/en not_active Expired - Fee Related
- 2009-09-24 US US12/566,392 patent/US20100200782A1/en not_active Abandoned
-
2012
- 2012-01-27 US US13/360,261 patent/US8695640B2/en not_active Expired - Fee Related
-
2014
- 2014-03-18 US US14/218,872 patent/US20140322489A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2721172A1 (en) | Microfabricated elastomeric valve and pump systems | |
US6644944B2 (en) | Uni-directional flow microfluidic components | |
EP1331997B1 (en) | Microfluidic flow control devices | |
US8202489B2 (en) | Disposable cassette | |
AU5980800A (en) | Polymer valves | |
JP2005096072A5 (en) | ||
CA2165425A1 (en) | Diaphragm valve | |
US6105610A (en) | Cartridge valve with triple sequential seal | |
WO2002070932A3 (en) | Microvalve | |
AU7587200A (en) | Dual diaphragm pump | |
WO2002022492A8 (en) | Microelectromechanical flexible membrane electrostatic valve device and related fabrication methods | |
WO2002097865A3 (en) | Fluidic valves, agitators, and pumps and methods thereof | |
WO2004058425A8 (en) | Micro electromechanical systems for delivering high purity fluids in a chemical delivery system | |
EP2069662B1 (en) | Valve seal member and valve | |
US6007046A (en) | Fluid transport circuit and valve structure therefor | |
US4478424A (en) | Ferrofluid seal apparatus and method | |
EP1531002A3 (en) | Device and method to electrostatically seal microfluidic devices | |
US6845965B2 (en) | Pressurized valve seal | |
US20020129857A1 (en) | Microvalve devices | |
EP1834098B1 (en) | Microfluidic modulating valve | |
WO1989001241A1 (en) | Sealing method and means for fluid control device | |
CA2421943A1 (en) | Pressure regulating buffer seal | |
US4931601A (en) | Pressure switch having internal vent chamber | |
RU2008129186A (en) | METHOD FOR FORMING A MICROFLUID REACTOR SEALED CHANNEL AND A MICROFLUID REACTOR CONTAINING SUCH CHANNEL | |
EP1861643B1 (en) | Valve seat |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20200629 |