CA2724266A1 - Fluid dispense and liquid surface verification system and method - Google Patents

Fluid dispense and liquid surface verification system and method Download PDF

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Publication number
CA2724266A1
CA2724266A1 CA 2724266 CA2724266A CA2724266A1 CA 2724266 A1 CA2724266 A1 CA 2724266A1 CA 2724266 CA2724266 CA 2724266 CA 2724266 A CA2724266 A CA 2724266A CA 2724266 A1 CA2724266 A1 CA 2724266A1
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CA
Canada
Prior art keywords
signal
receiving device
fluid surface
received signal
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2724266
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French (fr)
Other versions
CA2724266C (en
Inventor
James Lipscomb
Larry Jurik
Bernard Katz
Michael Keating
Stone Klenger
John Kotlarik
Mike Wroblewski
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Gen Probe Inc
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Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Publication of CA2724266A1 publication Critical patent/CA2724266A1/en
Application granted granted Critical
Publication of CA2724266C publication Critical patent/CA2724266C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8158—With indicator, register, recorder, alarm or inspection means
    • Y10T137/8326—Fluid pressure responsive indicator, recorder or alarm

Abstract

Methods of detecting a fluid surface are provided which comprise transmitting a signal with a signal transmitting device, receiving at least a portion of the signal with a signal receiving device and detecting a change in at least one characteristic of the received signal as an indication that the signal receiving device has contacted the fluid surface. The signal may be an RF signal. The characteristic may be a change in amplitude and the method may also comprise minimizing the amplitude of the received signal prior to contacting the fluid surface. The characteristic may be a phase shift between transmitted and received signals. The method may involve tuning a receiver circuit operatively coupled to the signal receiving device to be near resonance prior to contact of the fluid surface. The tuning may comprise tuning the receiver circuit so as to be about 2-5% below resonance prior to such contacting.

Claims (19)

1. A method of detecting a fluid surface comprising:
transmitting a signal with a signal transmitting device;

receiving at least a portion of the signal with a signal receiving device;

detecting a change in amplitude of the received signal as an indication that the signal receiving device has contacted the fluid surface; and minimizing the amplitude of the received signal prior to contacting the fluid surface with the signal receiving device.
2. The method of claim 1, further comprising grounding the signal transmitting device when the signal receiving device is in a predetermined position not in contact with the fluid surface.
3. The method of claim 1 or 2, further comprising amplifying the received signal prior to detecting the changes in the amplitude of the received signal after contacting the fluid surface with the signal receiving device.
4. The method of claim 1 or 2, further comprising amplifying the received signal prior to detecting the changes in the amplitude of the received signal after contacting the fluid surface with the signal receiving device and comparing the minimized received signal to the amplified received signal.
5. The method of claim 1, 2, or 3, further comprising amplifying the received signal to either a high or low gain level to increase the measured amplitude of the received signal to a desired level.
6. The method of claim 5, wherein the low gain level amplification corresponds to contact of the signal receiving device with a conductive fluid.
7. The method of claim 5 or 6, wherein the high gain level amplification corresponds to contact of the signal receiving device with a non-conductive fluid.
8. The method of any one of claims 3 to 7, wherein the step of amplifying the received signal further comprises amplifying the amplitude of the received signal to substantially the same amplitude as the transmitted signal.
9. The method of any one of claims 3 to 7, wherein the step of amplifying the received signal further comprises dynamically adjusting the amplification level according to the measured amplitude of the received signal.
10. The method of any one of claims 1 to 9, further comprising tuning the received signal so that the relationship between changes caused by contacting the fluid surface and changes in an amplitude of the received signal is monotonic.
11. A method of detecting a fluid surface comprising:
transmitting an RF signal with a signal transmitting device;

receiving at least a portion of the signal with a signal receiving device; and detecting a change in at least one characteristic of the received signal as an indication that the signal receiving device has contacted the fluid surface.
12. The method of detecting a fluid surface of claim 11, wherein the signal receiving device is mobile.
13. The method of detecting a fluid surface of claim 11 or 12, further comprising moving the signal receiving device into contact with the fluid surface.
14. A method of detecting a fluid surface comprising:
transmitting a signal with a signal transmitting device;

receiving at least a portion of the signal with a signal receiving device; and detecting changes in a phase shift between the transmitted and received signals as an indication that the signal receiving device has contacted the fluid surface.
15. The method of claim 14, further comprising tuning the received signal so that the transmitted and received signals are near resonance prior to the signal receiving device contacting the fluid surface.
16. The method of claim 14, further comprising tuning the received signal so that the phase difference between the transmitted and received signals is small prior to the signal receiving device contacting the fluid surface.
17. The method of claim 16, further comprising tuning the received signal so that there is about a 2-5% phase difference between the transmitted and received signals prior to the signal receiving device contacting the fluid surface.
18. The method of claim 14, further comprising tuning the received signal so that the relationship between contacting the fluid surface and phase shift between the transmitted and received signals is monotonic.
19. A method of detecting a fluid surface comprising:
transmitting a signal with a signal transmitting device;

receiving at least a portion of the signal with a signal receiving device;
detecting a change in at least one characteristic of the received signal as an indication that the signal receiving device has contacted the fluid surface;
and tuning a receiver circuit operatively coupled to the signal receiving device to be near resonance prior to the signal receiving device contacting the fluid surface, wherein said tuning step comprises tuning the receiver circuit so as to be about 2-5%
below resonance prior to the signal receiving device contacting the fluid surface.
CA 2724266 2000-02-29 2001-02-28 Fluid dispense and liquid surface verification system and method Expired - Fee Related CA2724266C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18574100P 2000-02-29 2000-02-29
US60/185,741 2000-02-29
CA 2399181 CA2399181C (en) 2000-02-29 2001-02-28 Fluid dispense and liquid surface verification system and method

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA 2399181 Division CA2399181C (en) 2000-02-29 2001-02-28 Fluid dispense and liquid surface verification system and method

Publications (2)

Publication Number Publication Date
CA2724266A1 true CA2724266A1 (en) 2001-09-07
CA2724266C CA2724266C (en) 2012-12-04

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CA 2724266 Expired - Fee Related CA2724266C (en) 2000-02-29 2001-02-28 Fluid dispense and liquid surface verification system and method
CA 2658772 Expired - Lifetime CA2658772C (en) 2000-02-29 2001-02-28 Fluid dispense and liquid surface verification system and method
CA 2399181 Expired - Fee Related CA2399181C (en) 2000-02-29 2001-02-28 Fluid dispense and liquid surface verification system and method

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CA 2658772 Expired - Lifetime CA2658772C (en) 2000-02-29 2001-02-28 Fluid dispense and liquid surface verification system and method
CA 2399181 Expired - Fee Related CA2399181C (en) 2000-02-29 2001-02-28 Fluid dispense and liquid surface verification system and method

Country Status (6)

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US (5) US6604054B2 (en)
EP (2) EP2230521A3 (en)
JP (2) JP4717312B2 (en)
AU (2) AU4536501A (en)
CA (3) CA2724266C (en)
WO (1) WO2001065214A2 (en)

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