CA2784937A1 - Ccr9 inhibitors and methods of use thereof - Google Patents

Ccr9 inhibitors and methods of use thereof Download PDF

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Publication number
CA2784937A1
CA2784937A1 CA2784937A CA2784937A CA2784937A1 CA 2784937 A1 CA2784937 A1 CA 2784937A1 CA 2784937 A CA2784937 A CA 2784937A CA 2784937 A CA2784937 A CA 2784937A CA 2784937 A1 CA2784937 A1 CA 2784937A1
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Prior art keywords
compound
pharmaceutically acceptable
disease
acceptable salt
formula
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CA2784937A
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French (fr)
Inventor
Paul Fleming
Geraldine C. B. Harriman
Zhan Shi
Shaowu Chen
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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Publication of CA2784937A1 publication Critical patent/CA2784937A1/en
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Abstract

The invention relates to compounds represented by Structural Formula I, (see formula I) which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.

Description

BACKGROUND OF THE INVENTION
[0002] Chemokines are a large and growing family of nearly forty 6-14 kD (non-glycosylated) heparin binding proteins that mediate a wide range of biological functions (Taub, D.D. and Openheim, J.J., Ther. Immunol., 1:229-246 (1994)). The chemokines can be divided into families based on the position of four cysteine residues that form two disulfide bonds (Kelner, G.S., et al., Science, 266:12395-1399 (1994); Bazan, J.F., et al., Nature, 385:640-644 (1997); Pin, Y., et al., Nature, 385:611-617 (1997)). Chemokine receptors can also be divided into families based on the type of chemokine they bind, although, no clear structural differences have been identified that distinguish the receptor sub-families (Mackay, C.R., J. Exp.Med., 184:799-802 (1996)).
[0003] Chemokines play a vital role in leukocyte adhesion and extravasation.
For example, in various in vitro assays, chemokines can induce the chemotaxis or transendothelial migration of leukocytes (Taub, D.D. and Openheim, J.J., Ther. Ininiunol., 1:229-246 (1994)), while in vivo injection (Taub, D.D., et al., J. Clin. Invest., 97:1931-1941 (1996)) or over-expression of chemokines (Fuentes, M.E., et al., J. Immunol., 155:5769-5776 (1995)) can result in leukocyte accumulation at the site of chemokine injection or expression.
Antagonists of chemokines can prevent leukocyte trafficking (Bargatze, R.F.
and Butcher, E.C., J. Exp. Med., 178:367-372 (1993)) and may have beneficial effects on acute and chronic inflammation (Sekido, N., et al., Nature, 365:654-657 (1993); Karpus, W.J., et al., J.
Immunol., 155:5003-5010 (1995)). Chemokines have also been reported to modulate angiogenesis (Gupta, S.K., et al., Proc. Natl. Acad. Sci. USA, 92:7799-7803 (1995)), hematopoiesis (Taub, D.D. and Openheim, J.J., Ther. Immunol., 1:229-246 (1994)) as well as T lymphocyte activation (Zhou, Z., et al., J. In7inunol. 151:4333-4341 (1993);
Taub, D.D., et al., J. Immunol., 156:2095-2103 (1996)). In addition, several chemokine receptors act as co-receptors, along with CD4, for entry of M tropic and T tropic HIV-1 (Choe, H., et al., Cell, 85:1135-1148 (1996); Feng, Y., et al., Science, 272:872-877 (1996)).
[0004] Several subsets of CD4 lymphocytes can be defined based on their expression of various adhesion molecules that are known to effect trafficking to different physiologic sites (Mackay, C.R., Curr. Opin. Ininunol., 5:423-427 (1993)). For example, CLA+ve memory CD4 lymphocytes traffic to the skin (Berg, E.L., et al., Nature, 174(6):1461-1466 (1991)), while CLA" a4(37{"' memory CD4 lymphocytes traffic to mucosal sites (Hainman, A., et al., J. linniunol., 152:3282-3292 (1994)). Leukocyte adhesion to endothelium is thought to involve several overlapping steps including rolling, activation and arrest. Rolling leukocytes are exposed to factors expressed at the adhesion site resulting in activation of the leukocyte and up-regulation of integrin-mediated adhesion. As a consequence of such integrin-mediated interactions, leukocytes arrest on the endothelium (Bargatze, R.F. and Butcher, E.C., J. Exp. Med., 178:367-372 (1993); Bargatze, R.F., et al., Immunity, 3:99-108 (1995)). Leukocyte activation and up-regulation of integrin molecules occurs via a pertussis toxin sensitive mechanism that is thought to involve chemokine receptors (Bargatze, R.F. and Butcher, E.C., J. Exp. M1ed., 178:367-372 (1993); Campbell, J.J., et at., Science, 279:381-383 (1998)).
[0005] Memory CD4+ lymphocytes can be grouped based upon the expression of certain chemokine receptors. For example, CXCR3, CCR2 and CCR5 (Qin, S., et al., Eur. J.
Inmunol., 26:640-647 (1996); Qin, S., et al., J. Clin. Invest., 101:746-754 (1998); Liao, F., et al., J. Innnunol., 162:186-194 (1999)) are all expressed on subsets of memory lymphocytes, and certain chemokines act selectively on naive T cells (Adema, G.J., et at., Nature, 387:713-717 (1997)). Furthermore, several chemokines which are ligands for such receptors have been shown to be expressed in inflammatory sites (Gonzalo, J.A., et al., J.
Clin. Invest., 98:2332-2345 (1996)) and in some cases in lymph nodes draining a challenged site (Tedla, N., et al., J. Imnunol., 161:5663-5672 (1998)). In vitro derived THl/TH2 lymphocyte lines have also been shown to differentially express chemokine receptors.
Specifically, TH1 lymphocytes have been shown to selectively express CXCR3 and CCR5, while TH2 lymphocytes selectively express CCR4, CCR8 and CCR3 (Bonecchi, R.G., et al., J.Exp. Med., 187:129-134 (1998); Sallusto, F.D.,.et al., J. Exp. Med., 187:875-883 (1998);
Sallusto, F., Science, 277:2005-2007 (1997); Andrew, D.P., et al., J. In.munol 161:5027-5038 (1998); Zingoni, A., et al., J. hnununol., 161:547-555 (1998)). Interestingly, in some cases th, chemokines for these respective chemokine receptors, such as MDC for CCR4 and IP-10 for CXCR3, are induced by cytokines associated with a TH1/TH2 environment (Andrew, D.P., et al., J. Iinniunol 161:5027-5038(1998); Luster, A.D., et al., Nature, 315:672-676 (1985)).
SUMMARY OF THE INVENTION
[0006] The present invention relates to compounds represented by Structural Formula I, and pharmaceutically acceptable salts, solvates, and hydrates of such compounds:

Rs Ar N

Y
XhI \Ar1 t~ A
X2' I.

[00071 In Structural Formula I, Y is C(O), 0, S, S(O) or S(O)2; X1, X2, and X3 are each, independently, N or CR, provided that at least one of X1, X2, or X3 is CR; R, for each occurrence, and R1 are each, independently, H or a substituent. In preferred embodiments, the substituents at positions R and R, are each, independently, an aliphatic group, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, sulonamido, sulfone, sulfoxide, hydroxy, NR11CO2R12, C(O)N(R11)2, C(O)R12, C02R12, OC(O)N(R11)2, OC(O)R12, N(R11)2, or NR11C(O)R12. R11 and R12 are defined further herein; R6 is H, an aliphatic carbonyl group, or an aliphatic ester; and Art and Are are each, independently, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group. Preferably, Arl is a substituted or unsubstituted phenyl, a substituted or unsubstituted pyridyl, a substituted or unsubstituted pyrimidinyl, or a substituted or unsubstituted pyrazinyl. Preferably, Are is a substituted or unsubstituted phenyl, or a substituted or unsubstituted pyridyl. More preferably, Arl is a substituted phenyl and Are is substituted pyridyl. Ring A is substituted or unsubstituted.

[00081 In a preferred embodiment, compounds of the invention are represented by Structural Formula H:

0 . \S 0 NH O
C

I A I B

II.

[0009] In Structural Formula II, X4 is N, N}-O-, or CR; and ring A, ring B, and ring C
are each, independently, substituted or unsubstituted. R is H or a substituent. Examples of substituents for R are defined as in Structural Formula I.

[00010] In a more preferred embodiment, compounds of the invention are represented by Structural Formula W.

o S

I C

N
A I B

Ra III.

[00011] In Structural Formula III, X4 is N, N+-O" or CR; ring A, ring B, and ring C are each, independently, substituted or unsubstituted, and R is H or a substituent. Examples of substituents for R are defined as in Structural Formula I; and R8 is H or an electron withdrawing group. Preferably, R8 is a halo, nitro, alkylcarbonyl or trihaloalkyl. More preferably, R3 is Cl, Br or NO2.
[00012] In another preferred embodiment, compounds of the invention are represented by Structural Formula IV.

Ar 2 N O

N '----Arl IA

N.

[00013] In Structural Formula N, Art, Are, RI and R6 are defined as in Structural Formula I; and R19 and R20 are each, independently, H or a substituent.
Examples of substituents in the R19 and R20 positions include an aliphatic group, a haloalkyl group, an ester, an amide, alkylcarbonyl, a halogen, COOH, NO2, alkoxy, haloalkoxy, CN, amino, and aminoalkyl.
[00014] In another preferred embodiment, compounds of the invention are represented by Structural Formula V.

0 Ar N 0 R2 Rs x2~ / / x4 V.

[00015] In Structural Formula V, X4 is CR, N or N+-O-; X1, X2, X3, R, and Are are defined as in Structural Formula I; R1, R2, R3, R4, R5, are, independently, H, an aliphatic group, a haloalkyl group, a halo, COOH, NO2, or an alkoxy, a haloalkoxy.

[00016] In a more preferred embodiment, compounds of the invention are represented by Structural Formula VI.

S

(R9)n (R1o)m RB

VI.
[00017] In Structural Formula VI, X1 is defined as in Structural Formula I; X4 is defined as in Structural Formula V; R$ is H or an electron withdrawing group;
m and n are each, independently, 0 or an integer from 1 to 3; each R9 is, independently, aliphatic group, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, hydroxy, NRIIC02R12, C(O)N(R11)2, C(O)R12, C02R12, OC(O)N(R11)2, OC(O)RI2, N(RII)2, or NR11C(O)R12; or two adjacent R9 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1, or 2 heteroatoms selected from N, 0, and S; each R10 is, independently, halo, aliphatic group, alkoxy, or haloalkyl; or two adjacent Rio groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1 or 2 heteroatoms selected from N, 0, and S; each R11 is, independently, selected from H or an aliphatic group; and R12 is an aliphatic group.

[00018] In another preferred embodiment, compounds of the invention are represented by Structural Formula VII.

\o s-jS NH 0 / X
(ROP
B
Ha VII.

[00019] In Structural Formula VII, ring B is substituted or unsubstituted; X1 is defined as in Structural Formula I; R8 is defined as in Structural Formula VI; p is 0 or an integer from 1-3; and each R13 is, independently, a halo or a substituted or unsubstituted heteroaryl.

[00020] In another preferred embodiment, compounds of the invention are represented by Structural Formula VIII.

Ar S\N/Rs X
A

VIII.

[00021] In Structural Formula VIII, ring A, Art, Are, X1, R1, R6 are defined as in Structural Formula I; R19 and R20 are defined as in Structural Formula IV; and Y1 is S, 0, S(O), or S(O)2.
[00022] The present invention provides a method of inhibiting a CCR9 receptor by contacting the receptor with an effective amount of a compound of the present invention, and/or pharmaceutically acceptable salts, solvates and hydrates thereof.

[00023] In one embodiment, the invention provides a method of inhibiting CCR9-mediated homing of leukocytes in a subject by administering to the subject an effective amount of a compound of the present invention, and/or pharmaceutically acceptable salts, solvates and hydrates thereof. In a preferred embodiment, the method inhibits homing of leukocytes to mucosal tissue.
[00024] In another embodiment, the invention provides a method of treating a subject having a disease that is mediated by a CCR9 receptor, such as an inflammatory disease, for example Celiac's disease or an inflammatory bowel disease, by administering to the subject an effective amount of a compound of the present invention, and/or pharmaceutically acceptable salts, solvates and hydrates thereof.
[00025] The present invention provides a pharmaceutical composition having a pharmaceutically acceptable carrier and at least one compound of the present invention.
[00026] Chemokines and their associated receptors (e.g., TECK and CCR9, respectively) are proinflammatory mediators that promote recruitment and activation of multiple lineages of leukocytes and lymphocytes. Continuous release of chemokines at sites of inflammation mediates the ongoing migration of effector cells in chronic inflammation. CCR9 and its associated chemokine TECK, have been implicated in chronic inflammatory diseases, such as inflammatory bowel diseases. Small molecule inhibitors of the interaction between CCR9 and its ligands (e.g., TECK), such as the compounds of the invention, are useful for inhibiting harmful inflammatory processes triggered by receptor-ligand interactions and thus are useful for treating diseases mediated by CCR9, such as chronic inflammatory diseases.
In one aspect, there is provided a compound having the following structural formula:

NH
n(R9) I
/ Y
-(RI I)m or a pharmaceutically acceptable salt thereof, wherein: Y is C=O; R8 is halo, nitro, alkylcarbonyl, or trihaloalkyl; in and n are each, independently, 0 or an integer from 1 to 3; each R9 is, independently, aliphatic, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, hydroxy, NR11CO2R12, C(O)N(R11)2, C(O)R12, CO2R12, OC(O)N(R11)2, OC(O)R12, N(RI)2, or NR11C(O)R12;
or two adjacent R9 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1, or 8a 2 heteroatoms selected from N, 0, and S; wherein each RI I is, independently, selected from H or an aliphatic group; and R12 is an aliphatic group; and each Rio is, independently, halo, aliphatic group, alkoxy, or haloalkyl.
In another aspect, there is provided a pharmaceutical composition comprising a compound having the following structural formula:

Are 'NH

Y--,Ar1 or a pharmaceutically acceptable salt thereof, wherein: Y is C=O, S(O), or S(O)2; R8 is halo, nitro, alkylcarbonyl, or trihaloalkyl; Arl is substituted or unsubstituted phenyl; and Are is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, and a pharmaceutically acceptable carrier.
In another aspect, there is provided the pharmaceutical composition as described herein, wherein the compound is represented by the following structural formula:

"NH
n(R9) / I Y

(R10)m wherein: Y is C=O; R8 is halo, nitro, alkylcarbonyl, or trihaloalkyl; in and n are each, independently, 0 or an integer from 1 to 3; each R9 is, independently, aliphatic, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, hydroxy, NRIICO2R12, C(O)N(R11)2, C(O)R12, C02R12, OC(0)N(R11)2, OC(O)R12, N(R11)2, or NR11C(O)R12; or two adjacent R9 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 8b membered ring having 0, 1, or 2 heteroatoms selected from N, 0, and S; wherein each R11 is, independently, selected from H or an aliphatic group; and R12 is an aliphatic group; and each R10 is, independently, halo, aliphatic group, alkoxy, or haloalkyl; or two adjacent R10 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1 or 2 heteroatoms selected from N, 0, and S.
In another aspect, there is provided a method of treating an inflammatory bowel disease in a subject in need thereof, comprising administering to the subject an effective amount of a compound represented by the following structural formula:

0 Ar2 ~S 0 Y
Xi -A r1 II A
X2~ X3 Ri or a pharmaceutically acceptable salt thereof, wherein:Y is C=O, S(O), or S(0)2; X1, X2, and X3 are each independently CR; R, for each occurrence, and R1 are each independently H, an aliphatic group, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, hydroxy, NR11CO2R12, C(0)N(R11)2, C(0)R12, CO2R12, OC(O)N(R11)2, OC(O)R12, N(R11)2, or NR11C(O)R12; wherein R11, for each occurrence is, independently, H or an aliphatic group, and R12 is an aliphatic group;
R6 is H, an aliphatic carbonyl group, or an aliphatic ester;Ar1 is substituted or unsubstituted phenyl; and Are is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group.
In another aspect, there is provided the method as described herein, wherein the compound is represented by the following structural formula:

~NH
n~R9~ I

-(R10)m wherein: Y is C=O; Rg is halo, nitro, alkylcarbonyl, or trihaloalkyl; in and n are each, independently, 0 or an integer from I to 3; each R9 is, independently, aliphatic, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, hydroxy, NR11CO2R1Z, C(O)N(R11)2, C(O)R12, C02R 12, OC(O)N(R11)2, OC(O)R12, N(R11)2, or NR11C(O)R12; or two adjacent R9 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1, or 2 heteroatoms selected from N, 0, and S; wherein each R11 is, independently, selected from H or an aliphatic group; and R12 is an aliphatic group; and each Rio is, independently, halo, aliphatic group, alkoxy, or haloalkyl; or two adjacent Rio groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1 or 2 heteroatoms selected from N, 0, and S.
In another aspect, there are also provided pharmaceutical compositions, uses and commercial packages comprising the compounds described herein.
DETAILED DESCRIPTION OF THE INVENTION
[00027] The term "aliphatic" as used herein means straight-chain, branched or cyclic CI-C12 hydrocarbons which are completely saturated or which contain one or more units of unsaturation but which are not aromatic. For example, suitable aliphatic groups include substituted or unsubstituted linear, branched or cyclic alkyl, alkenyl, alkynyl groups and hybrids thereof such as (cycloalkyl)alkyl, (cycloalkenyl)alkyl or (cycloalkyl)alkenyl. The terms "alkyl", "alkoxy", and "alkylthio", used alone or as part of a larger moiety includes both straight and branched chains containing one to twelve carbon atoms. The terms "alkenyl" and alkynyl" used alone or as part of a larger moiety shall include both straight and branched chains containing two to twelve carbon atoms. The term "cycloalkyl" used alone or as part of a larger moiety shall include cyclic C3-C12 hydrocarbons which are completely saturated or which contain one or more units of unsaturation, but which are not aromatic.
[00028] As used herein, aryl groups are carbocyclic aromatic ring systems (e.g.
phenyl), fused polycyclic aromatic ring systems (e.g. naphthyl and anthracenyl) and aromatic ring systems fused to carbocyclic non-aromatic ring systems (e.g., 1,2,3,4-tetrahydronaphthyl) having six to about fourteen carbon atoms.
[00029] The terms "haloalkyl", "haloalkenyl" and "haloalkoxy" means alkyl, alkenyl or alkoxy, as the case may be, substituted with one or more halogen atoms. The term "halogen"
means F, Cl, Br or I.

[00030] The term "aryl" used alone or as part of a larger moiety as in "aralkyl", "aralkoxy", or "aryloxyalkyl", refers to aromatic ring groups having five to fourteen members, such as phenyl, benzyl, phenethyl, 1-napthyl, 2-naphthyl, 1-anthracyl and 2-anthracyl. The term "aryl" also refers to rings that are optionally substituted. The term "aryl"
may be used interchangeably with the term "aryl ring". "Aryl" also includes fused polycyclic aromatic ring systems in which an aromatic ring is fused to one or more rings.
Examples include 1-naphthyl, 2-naphthyl, 1-anthracyl and 2-anthracyl. Also included within the scope of the term "aryl", as it is used herein, is a group in which an aromatic ring is fused to one or more non-aromatic rings, such as in an indanyl, phenantriidinyl, or tetrahydronaphthyl, where the radical or point of attachment is on the aromatic ring.

[00031] The term "heteroatom" means nitrogen, oxygen, or sulfur and includes any oxidized form of nitrogen and sulfur, and the quaternized form of any basic nitrogen. Also the term "nitrogen" includes a substitutable nitrogen of a heterocyclic ring.
As an example, in a saturated or partially unsaturated ring having 0-3 heteroatoms selected from oxygen, sulfur or nitrogen, the nitrogen may be N (as in 3,4-dihydro-2H-pyrrolyl), NH (as in pyrrolidinyl) or NR18 (as in N-substituted pyrrolidinyl).

[00032] The term "heterocycle", as used herein includes non-aromatic ring systems having five to fourteen members, preferably five to ten, in which one or more ring carbons, preferably one to four, are each replaced by a heteroatom such as N, 0, or S.
Examples of heterocyclic rings include 3-1H-benzimidazol-2-one, 3-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 4-tetrahydropyranyl, [1,3]-dioxalanyl, [1,3]-dithiolanyl, [1,3]-dioxanyl, 2-tetrahydrothiophenyl, 3-tetrahydrothiophenyl, 2-morpholinyl, 3-morpholinyl, 4-morpholinyl, 2-thiomorpholinyl, 3-thiomorpholinyl, 4-thiomorpholinyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrorolidinyl, 1-piperazinyl, 2-piperazinyl, 1-piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, 4-thiazolidinyl, diazolonyl, N-substituted diazolonyl, 1-pthalimidinyl, benzoxanyl, benzopyrrolidinyl, benzopiperidinyl, benzoxolanyl, benzothiolanyl, and benzothianyl. Also included within the scope of the term "heterocycle", as it is used herein, is a group in which a non-aromatic heteroatom-containing ring is fused to one or more aromatic or non-aromatic rings, such as in an indolinyl, chromanyl, phenantrhidinyl, or tetrahydroquinolinyl, where the radical or point of attachment is on the non-aromatic heteroatom-containing ring. The term "heterocycle", whether saturated or partially unsaturated, also refers to rings that are optionally substituted.

[00033] The term "heteroaryl", used alone or as part of a larger moiety as in "heteroaralkyl" or "heteroarylalkoxy", refers to heteroaromatic ring groups having five to fourteen members. Examples of heteroaryl rings include 2-furanyl, 3-furanyl, N-imidazolyl, 2 imidazolyl, 4-imidazolyl, 5-imidazolyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, 2-oxadiazolyl, 5-oxadiazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 3-pyridazinyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 2-triazoly], 5-triazolyl, 2-thienyl, 3-thienyl, thianaphthenyl, carbazolyl, benzimidazolyl, benzothienyl, benzofuranyl, indolyl, quinolinyl, benzotriazolyl, benzothiazolyl, benzooxazolyl, benzimidazolyl, isoquinolinyl, indolyl, isoindolyl, acridinyl, or benzoiriazolyl. Also included within the scope of the term "heteroaryl", as it is used herein, is a group in which a heteroatomic ring is fused to one or more aromatic or nonaromatic rings where the radical or point of attachment is on the heteroaromatic ring. Examples include tetrahydroquinolinyl, tetrahydroisoquinolinyl, and pyrido [3, 4-d] pyrimidinyl. The term "heteroaryl" also refers to rings that are optionally substituted. Preferred heteroaryl groups are thienyl, benzo(b)thienyl, pyrrolyl, indolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, furanyl, and benzo(b)furanyl.
More preferred heteroaryl groups are pyridyl and thienyl.

[000341 An arylalkyl group, as used herein, is an aryl substituent that is linked to a compound by an alkyl group having from one to twelve carbon atoms.

[00035) An alkoxy group, as used herein, is a CI-Ct2 alkyl group that is connected to a compound via an oxygen atom. Examples of alkoxy groups include but are not limited to methoxy, ethoxy, propoxy, isopropoxy, and t-butoxy.

[00036] A cycloalkoxy group, as used herein, is a a cyclic C3-C12 hydrocarbon which is attached to a compound via an oxygen. Cycloalkoxy groups include but are not limited to cyclopropoxy and cyclobutoxy.

[00037] A haloalkoxy, as used herein, is a haloalkyl group that is attached to a compound via an oxygen. A preferred haloalkoxy is trifluoromethoxy.

[00038] An aryloxy, as used herein, is an aryl group that is attached to a compound via an oxygen. A preferred aryloxy is phenoxy.

[00039] A arylalkoxy group, as used herein, is a arylalkyl group that is attached to a compound via an oxygen on the C1-C12 alkyl portion of the arylalkyl. A
preferred arylalkoxy is phenylmethoxy.

[00040] An alklythio group, as used herein, is a C1-C12 alkyl group that is connected to a compound via a sulfur atom.

[00041] A aliphatic carbonyl group, as used herein, is an aliphatic group that is connected to a compound via a carbonyl group. A preferred aliphatic carbonyl is acetyl.
[00042]. A aliphatic ester group, as used herein, an aliphatic group that is connected to a compound via an ester linkage (i.e., -C(O)O-aliphatic group).

[00043] An electron withdrawing group is a group which causes a dipole moment in the direction of the group. Suitable electron withdrawing groups include but are not limited to halo (preferably chloro), haloalkyl (preferably trifluoromethyl), nitro, cyano, sulfonamido, sulfone, and sulfoxide.

[00044] An aryl (including aralkyl, aralkoxy, aryloxyalkyl and the like) or heteroaryl (including heteroaralkyl and heteroarylalkoxy and the like) may contain one or more substituents. Examples of suitable substituents include aliphatic groups, aryl groups, haloalkoxy groups, heteroaryl groups, halo, hydroxy, OR14, COR14, COOR14, NHCOR14, OCOR14i benzyl, haloalkyl (e.g., trifluoromethyl and trichloromethyl), cyano, nitro, S(O),S(O)2, SO3-, SH, SR14, NH2, NHR14, NR14R15, NR6S(O)2-R7, and COOH, wherein R14 and R15 are each, independently, an aliphatic group, a cycloalkyl, an aryl group, or an arylalky group. Other substituents for an aryl or heteroaryl group include -R16, -OR16, -SR16, 1,2-methylene-dioxy, 1, 2-ethylenedioxy; protected OH (such as acyloxy), phenyl (Ph), substituted Ph, -O(Ph), substituted -O(Ph), -CH2(Ph), substituted -CI2CH2(Ph), substituted -CH2CH2(Ph), -N(R16)2, -NR16CO2R16, -NR16NR16C(O)R16, -NR16R16C(O)N(R16)2, -NR16NR16C02R16, -C(O)C(O)R16/,p-C(O)CH2C(O)R16, -C02R16, -C(O)R16, -C(O)N(R16)2, -OC(O)N(R16)2, -S(O)2R16, -SO2N(R16)2, -S(O)R16, -NR16SO2N(R16)2, -NR16S02R16, -C(=S)N(R16)2, -C(=NH)-N(R16)2, -(CH2)yNHC(O)R16, -(CH, )yNHC(O)CH(V-R16)(R16); wherein R16 is hydrogen, a substituted or unsubstituted heteroaryl or heterocyclic ring, phenyl (Ph), substituted Ph, -O(Ph), substituted -O(Ph), -CH2 (Ph), or substituted -CH2 (Ph); y is 0-6; and V is a linker group. Preferred substituents on the aryl or heteroaryl group include halo, haloalkyl, sulfone, sulfoxide, nitro, cyano, alkyl group, alkoxy group, and alkylamino group. Examples of substituents on the aliphatic group or the phenyl ring include amino, alkylamino, dialkylamino, aminocarbonyl, halogen, alkyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminocarbonyloxy, dialkylaminocarbonyloxy, alkoxy, nitro, cyano, carboxy, alkoxycarbonyl, alkylcarbonyl, hydroxy, haloalkoxy, or haloalkyl. Substituents for an aryl or a heteroaryl group include aryl groups (including a carbocyclic aryl group or a heteroaryl group), aliphatic groups, cycloalkyl groups, haloalkoxy groups, heteroaryl groups, hydroxy, OR14, aldehyde, COR14, COOR14, NHCOR14, OCOR14, benzyl, haloalkyl (e.g., trifluoromethyl and trichioromethyl), halo, cyano, nitro, S03-, SH, SR14, NH2, NHR14, NR14R15, NR6S(O)2-R7, or COOH, wherein R14 and R15 are each, independently, an aliphatic group, a cycloalkyl, an aryl group, or an arylalky group.

[00045] An aliphatic group or a heterocycle may contain one or more substituents.
Examples of suitable substituents on the saturated carbon of an aliphatic group of a heterocycle include those listed above for an aryl or heteroaryl group and the following: =0, =S, =NNHR17, =NN(R17)2, =NNHC(O)R17, =NNHCO2(alkyl), =NNHSO2(alkyl), or =NR17, where each R17 is independently selected from hydrogen, an unsubstituted aliphatic group or a substituted, aliphatic group. Examples of substituents on the aliphatic group include amino, alkylamino, dialkylamino, aminocarbonyl, halogen;, alkyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminocarbonyloxy, dialkylaminocarbonyloxy, alkoxy, thioalkyl, nitro, cyano, carboxy, alkoxycarbonyl, alkylcarbonyl, hydroxy, haloalkoxy,; or haloalkyh [00046] Suitable substitutents on the nitrogen of a non-aromatic heterocycle or on an unsaturated nitrogen of a heteroaryl include -R18, -N(R1S)2, -C(O)R18, -C02R18, -C(O)C(0)R18, -C(O)CH2C(O)R1s, -S02R18, -SO2N(R18)2, -C(=S)N(RIs)2, -C(=NH)-N(R18)2, and -NR15S02R18i wherein R18 is hydrogen, an aliphatic group, a substituted aliphatic group, phenyl (Ph), substituted Ph, -O(Ph), substituted -O(Ph), -CH2(Ph), or an unsubstituted heteroaryl or heterocyclic ring. Examples of substituents on the aliphatic group or the phenyl ring include amino, alkylamino, dialkylamino, aminocarbonyl, halogen, alkyl, alkylaminocarbonyl, dialkylaminocarbonyloxy, alkoxy, nitro, cyano, carboxy, alkoxycarbonyl, alkylcarbonyl, hydroxy, haloalkoxy, or haloalkyl.

[00047] The term "linker group" or "linker" means an organic moiety that connects two parts of a compound. Linkers are typically comprised of an atom, such as oxygen or sulfur, a unit, such as -NH-, -CH2-, -C(O)-, or -C(O)NH-, or a chain of atoms, such as an alkylene chain. The molecular mass of a linker is typically in the range of about 14 to 200, preferably in the range of 14 to 96 with a length of up to about six atoms.
Examples of linkers include a saturated or unsaturated C1-C6 alkylene chain which is substituted or unsubstituted, and wherein one or two saturated carbons of the chain are optionally replaced by -C(O)-, -C(O)C(O)-, -CONH-, -CONHNH-, -CO2-, -OC(O)-, -NHCO2-, -0-, -NHCONH-, -OC(O)NH-, -NHNH-, -NHCO-, -S-, -SO-, -SO2-, -NH-, -SO2NH-, or-NHSO2-.

[00048] It will be apparent to one skilled in the art that certain compounds of this invention may exist in tautomeric forms, all such tautomeric forms of the compounds being within the scope of the invention. Unless otherwise stated, structures depicted herein are also meant to include all stereochemical forms of the structure; i.e., the R and S
configurations for each asymmetric center. Therefore, single stereochemical isomers as well as enantiomeric and diastereomeric mixtures of the present compounds are within the scope of the invention.
Unless otherwise stated, structures depicted herein are also meant to include compounds which differ only in the presence of one or more isotopically enriched atoms.
For example, compounds having the present structure except for the replacement of a hydrogen by a deuterium or tritium, or the replacement of a carbon by a 13C- or 14C-enriched carbon are within the scope of this invention.

[00049] The compounds of the present invention have IC50s of less than 1 gm;
less than 750 nm; preferably less than 500 nm; more preferably less than 250 nm;
even more preferably less than 100 nm, most preferably less than 50 nm; and the most preferable less than 10 nm, e.g., less than 5 nm.

[00050] As used herein "mammalian CCR9" refers to naturally occurring or endogenous mammalian CCR9 proteins and to proteins having an amino acid sequence which is the same as that of a naturally occurring or endogenous corresponding mammalian CCR9 protein (e.g., recombinant proteins, synthetic proteins (i.e., produced using the methods of synthetic organic chemistry)). Accordingly, as defined herein, the term includes mature receptor protein, polymorphic or allelic variants, and other isoforms of a mammalian CCR9 (e.g., produced by alternative splicing or other cellular processes), and modified or unmodified forms of the foregoing (e.g., lipidated, glycosylated, unglycosylated). Naturally occurring or endogenous mammalian CCR9 proteins (see e.g., GenBank Accession Numbers NM_031200 and U45982 and Yu et at. (2000) J. Innmurzol. 164:1293-1305 which describe various forms of naturally occurring mammalian CCR9) include wild type proteins such as mature CCR9, polymorphic or allelic variants and other isoforms which occur naturally in mammals (e.g., humans, non-human primates). Such proteins can be recovered or isolated from a source which naturally produces mammalian CCR9, for example.
Polymorphic, allelic, splice and other naturally occurring variants of mammalian CCR9 can be expressed in particular organs, tissues or cells and have altered properties (e.g., altered affinity for ligand (e.g. TECK)) and specialized biological function (e.g., T cell development, T
cell recruitment). Naturally occurring or endogenous mammalian CCR9 proteins and proteins having the same amino acid sequence as a naturally occurring or endogenous corresponding mammalian CCR9, are referred to by the name of the corresponding mammal. For example, where the corresponding mammal is a human, the protein is designated as a human CCR9 protein (e.g., a recombinant human CCR9 produced in a suitable host cell).

[00051] As used herein "mammalian TECK" refers to naturally occurring or endogenous mammalian TECK proteins and to proteins having an amino acid sequence which is the same as that of a naturally occurring or endogenous corresponding mammalian TECK protein (e.g., recombinant proteins, synthetic proteins (i.e., produced using the methods of synthetic organic chemistry)). Accordingly, as defined herein, the term includes mature receptor protein, polymorphic or allelic variants, and other isoforms of a mammalian TECK (e.g., produced by alternative splicing or other cellular processes), and modified or unmodified forms of the foregoing (e.g., lipidated, glycosylated, unglycosylated). Naturally occurring or endogenous mammalian TECK proteins (see e.g., GenBank Accession Number U86358 and Vicari et al. (1997) Immunity 7:291-301 which describe naturally occurring mammalian TECK) include wild type proteins such as mature TECK, polymorphic or allelic variants and other isoforms which occur naturally in mammals (e.g., humans, non-human primates). Such proteins can be recovered or isolated from a source which naturally produces mammalian TECK, for example.
[00052] The term "pharmaceutically acceptable" means that the carrier, diluent, excipients and salt must be compatible with the other ingredients of the formulation, and not deleterious to the recipient thereof. Pharmaceutical formulations of the present invention are prepared by procedures known in the art using well known and readily available ingredients.

[00053] "Preventing" refers to reducing the likelihood that the recipient will incur or develop any of the pathological conditions described herein, for example inhibiting the onset of these symptoms.

[00054] "Treating" refers to eliminating or reducing the severity of a pathological condition described herein and/or eliminating, alleviating and/or reducing the symptoms of a pathological condition described herein.

[00055] Compounds of the invention can be used to treat a subject having an inflammatory disease. In one embodiment, the method is a method of inhibiting a CCR9 function in a subject. In particular embodiments, the method is a method of treating a subject having an inflammatory disease associated with mucosal tissue, such as Crohn's disease, colitis, or Celiac disease. In another embodiment, the method is a method of inhibiting CCR9-mediated homing of leukocytes in a subject. See Papadakis, et al., Gastroenterology (2001),121:246-254 for a discussion of the relationship of CCR9 receptors to the above diseases or conditions.

[00056] In one embodiment, the compounds of the invention are represented by any one of Structural Formulas IX-XXIV:

Are NH Ar NH

A B B
Y N r'y IX. X.
O`` O

Ar2 NH Ar'r NH

Y Y
A B NA B N
XI. X11.

\`~o \\~o 2 / NH Ar 2 NH
Ar Y Y. N
N
I A I B I A I B

XIII. XIV.

\`Zo \\/o Are NH Ar2 NH
N N N

N
XV. XVI.

o \`/o Ar / NH Ar2 S\NH

Y Y N
rBj A IA N

N
XVII XVIII.

\\~o \\io Ar2 / NH Ar2 NH

Y N
N N

IN / N
M. XX.

``/o. ``moo Are NH Ar j NH

Y N Y
N N ~ ~N
A $ I A B
N N
XXI. XXII.

\ '~"O \`''O
Are NH Are NH

N YyN N Y
A B A B
I N 11 ~~

XXIII= XXIV.

Are NH
\
A
/ Z B
N
N
XXV.

[00057] In Structural Formulas IX-XXV, Are and Y are defined as in Structural Formula I; and rings A and B are substituted or unsubstituted.
[00058] In another embodiment of the invention, compounds used in the method of the invention and in pharmaceutical compositions of the invention are represented by Structural Formula XXVI or XXVII:

I NH. O

XXVI.

S
NH O
S

(R13)P

XXVII.
[00059] In Structural Formulas XXVI and XXVII, R8 is defined as in Structural Formula V, and R13 and p are defined as in Structural Formula VII.

[00060] In a first preferred embodiment of the invention, Y in Structural Formula I, or IX-XXIV is C=O. -[00061] In a second preferred embodiment, ring C in Structural Formula II or III or Are in Structural Formula I, IV, V or in any one of Structural Formulas IX-XXV is unsubstituted or substituted with one or more substituents selected from aliphatic group (including substituted aliphatic groups such as haloalkyl) aryl, arylalkyl, alkoxy (including cycloalkoxy and substituted alkoxy groups such as haloalkoxy), aryloxy, arylalkoxy, alkyithio-, halo, nitro, cyano, S(O)-(aliphatic), S(0)2-(aliphatic), NR11S(O)2-(aliphatic), C(O)N(RI1)2, C(O)R12, N(RI1)2, NRIIC(O)2R12 and NRIIC(O)R12, wherein R11 for each occurrence is, independently, H or an aliphatic group, and R12 is an aliphatic group. More preferred substitutents for ring C
or R7 are selected from an aliphatic group, an alkoxy, and a haloalkoxy.

[00062] In a third preferred embodiment, ring A in Structural Formula I or IV, or one or both rings A and B in Structural Formula II or III or in any one of Structural Formulas IX-XXV are, independently, substituted with a stubstituent selected from halo, aliphatic group, alkoxy, and haloalkyl.
[00063] In a fourth preferred embodiment, ring A in Structural Formula 1,1I, III, IV, V, VI, VII, VIII, or in any one of Structural Formulas IX-XXV is substituted with an electron withdrawing substituent para to the sulfonamide group.

[00064] In a fifth preferred embodiment of the invention, X3 in Structural Formula V is CR21, wherein R21 is an electron withdrawing group. More preferably, R21 is halo, nitro, aliphatic carbonyl, or trihalomethyl. Most preferably, R21 is Cl, Br, or nitro.

[00065] In a sixth preferred embodiment of the invention, Are in Structural Formula I, IV, V, VIII or in any one of Structural Formulas IX-XXV is a substituted or unsubstituted phenyl, a substituted or unsubstituted naphthyl, a substituted or unsubstituted thienyl, or a substituted or unsubstituted thianaphthenyl. More preferably, Are is a substituted or unsubstituted phenyl or a substituted or unsubstituted thienyl.

[00066] In a seventh preferred embodiment of the invention, R9 for each occurrence in Structural Formula VI is, independently, an aliphatic group, an alkoxy, or a haloalkoxy.
[00067] In an eighth preferred embodiment of the invention, Rs in Structural Formula I, VI, VII, VIII, XXV and XXVI is a halo, nitro, alkylcarbonyl or trihaloalkyl.
More preferably, R8 is Cl, Br or NO2.
[00068] In an ninth preferred embodiment of the invention, Y and Ar2 in Structural Formula I and VIII or in any one of Structural Formulas IX-XXV are defined as in the first and the sixth preferred embodiments, respectively.
[00069] In a tenth preferred embodiment of the invention, Ar2 Structural Formula V is defined as in the sixth preferred embodiments, and X3 is defined as in the fifth preferred embodiment.
[00070] In an eleventh preferred embodiment, X4 in Structural Formulas V or VI
is an nitrogen oxide (N}-O-).
[00071] In a twelfth preferred embodiment, n is one in Structural Formula VI
and R9 is para to the sulfonamide substituent. More preferably, R9 is as defined in seventh preferred embodiment.

[00072] In a thirteen preferred embodiment, in is one in Structural Formula VI
and Rio is meta to the carbonyl substituent.

[00073] In a fourteenth preferred embodiment, R6 in Structural Formula 1, IV, or VIII
is H.

[00074] Specific examples of compounds used in the method of the invention and in pharmaceutical compositions of the invention include but are not limited to the compounds listed in Table 1. Pharmaceutically acceptable salts, solvates and hydrates of the compounds listed in Table 1 are also useful in the method of the invention and in pharmaceutical compositions of the invention.

Table 1: Specific compounds of the invention Example Compound Name 7 N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-4-nitro-benzenesulfonamide 8 Thiophene-2-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 9 N-(2-Benzoyl-4-chloro-phenyl)-4-iodo-benzenesulfonarnide 10 T-(2-Benzoyl-4-chloro-phenyl)-4-chloro-benzenesulfonamide 11 N-(2-Benzoyl-4-chloro-phenyl)-4-tert-butyl-benzenesulfonamide 12 N-(2-Benzoyl-4-chloro-phenyl)-4-propyl-benzenesulfonamide 13 N-(2-Benzoyl-4-chloro-phenyl)-4-ethyl-benzenesulfonamide 14 N-(2-Benzoyl-4-nitro-phenyl)-4-ethyl-benzenesulfonamide 15 N-(2-Benzoyl-4-chloro-phenyl)-4-isopropyl=benzenesulfonamide 16 N-(2-Benzoyl-4-bromo-phenyl)-4-ethyl-benzenesulfonamide 17 T-(2-Benzoyl-4-bromo-phenyl)-4-methoxy-benzenesulfonamide 18 N-(2-Benzoyl-4-bromo-phenyl)-4-isopropyl-benzenesulfonamide 19 4-Ethyl-N-[4-nitro-2-(3-trifluoromethyl-benzoyl)-phenyl]-benzenesulfonamide 20 N-[4-Chloro-2-(3-methyl-benzoyl)-phenyl]-4-ethyl-benzenesulfonamide 21 N-(2-Benzoyl-4-bromo-phenyl)-4-chloro-benzenesulfonamide 22 N-(2-Benzoyl-4-chloro-phenyl)-4-ethoxy-benzenesulfonamide 23 N-(2-Benzoyl-4-chloro-phenyl)-4-propoxy-benzenesulfonamide 24 N-(2-Benzoyl-4-chloro-phenyl)-4-isopropoxy-benzenesulfonamide N-(2-Benzoyl-4-chloro-phenyl)-4-butoxy-benzenesulfonanide 26 N-(2-Benzoyl-4-chloro-phenyl)-4-benzyloxy-benzenesulfonamide 27 N-(2-Benzoyl-4-chloro-phenyl)-4-phenoxy-benzenesulfonamide 31 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-isopropoxy-benzenesulfonamide 32 N-[4-Chloro-2-(pyridine-4-carbonyI)-phenyl]-4-ethoxy-benzenesulfonamide 33 N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isopropyl-benzenesulfonamide 34 N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isobutyl-benzenesulfonamide 35 N-[5-Chloro-3-(pyridine-4-carbonyl)-pyridin-2-yl]-4-ethoxy-benzenesulfonamide 36 N-[5-Chloro-3-(pyridine-4-carbonyl)-pyridin-2-yl]-4-isopropoxy-benzenesulfonamide 45 N-(3-Benzoyl-5-trifluoromethyl-pyridin-2-yl)--4-isopropoxy-benzenesulfonamide 46 N-(2-Benzoyl-4-nitro-phenyl)-4-chloro-benzenesulfonamide 47 5-Benzoyl-6-(4-isopropoxy-benzenesulfonylamino)-nicotinic acid 48 N-(2-Benzoyl-4-chloro-phenyl)-2-nitro-benzenesulfona ide 49 -(3-Benzoyl-5-nitro-pyridin-2-yl)-4-isopropoxy-benzenesulfonamide 50 N-(5-Benzoyl-pyrimidin-4-yl)-4-isopropoxy-benzenesulfonamide N-(3-13enzoyl-5-trifluoromethoxy-pyridin-2-yl)-4 isopropoxy-benzenesulfonamide 52 N-(5-Benzoyl-2-trifluoromethyl-pyrimidin-4-yl)-4-i sopropoxy-benzenesulfonamide 53 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-cyclopropoxy-benzenesulfonamide 54 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-cyelobutyl-benzenesulfonamide 55 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-tert-butoxy-benzenesulfonamide 56 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-cyclopentyl-benzenesulfonamide 57 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-isopropylsulfanyl-benzenesulfonamide 58 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-isopropylamino-benzenesulfonamide 59 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-cyclopropyl-benzenesulfonamide 60 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-cyclohexyl-benzenesulfonamide 61 -(3-Benzenesulfinyl-5-chloro-pyridin-2-yl)-4-isopropoxy-benzenesulfonamide 62 N-(3-Benzenesulfonyl-5-chloro-pyridin-2-yl)-4-isopropoxy-benzenesulfonamide 63 N-[4-Chloro-2-(pyrimidine-5-carbonyI)-phenyI]-4-isopropoxy-benzenesulfonamide 64 N-[4-Chloro-2-(pyridazine-4-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide 65 N-[4-Chloro-2-(2-trifluoromethyl-pyrimidine-5-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide 66 N-[4-Chloro-2-(6-trifluoromethyl-pyridazine-4-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide 67 N-[4-Chloro-2-(2-trifluoromethyl-pyrimidine-5-carbonyl)-phenyI]-4-i sopropoxy-benzenesulfonamide 68 -[4-Chloro-2-(6-trifluoromethyl-pyridazine-4-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide 69 -(2-Benzoyl-4-nitro-phenyl)-4-isopropyl-benzenesulfonamide 70 N-(2-Benzoyl-4-nitro-phenyl)-4-isopropoxy-benzenesulfonamide 71 N-(2-Benzoyl-4-nitro-phenyl)-4-methoxy-benzenesulfonamide 72 N-(2-Benzoyl-4-chloro-phenyl)-4-trifluoromethoxy-benzenesulfonamide 73 5-Oxazol-5-yl-thiophene-2-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 74 T-[4-Chloro-2-(3-chloro-benzoyl)-phenyl]-4-methoxy-benzenesulfonamide 75 N-(2-Benzoyl-4-chloro-phenyl)-4-methoxy-benzenesulfonamide 76 N-[4-Chloro-2-(3-chloro-benzoyl)-phenyl]-4-ethyl-benzenesulfonamide 77 N-(2-Benzoyl-4-chloro-phenyl)-4-ethylamino-benzenesulfonamide 78 5-(1-Methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-thiophene-2-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 79 N-(2-Benzoyl-4-iodo-phenyl)-4-isopropoxy-benzenesulfonamide 80 N-[4-Chloro-2-(3-fluoro-benzoyl)-phenyl]-4-methyl-benzenesulfonaride .
81 N-[4-Chloro-2-(3-chloro-benzoyl)-phenyl]-4-isopropyl-benzenesulfonamide 82 N-(2-Benzoyl-4-chloro-phenyl)-4-nitro-benzenesulfonamide 83 N-(2-Benzoyl-4-chloro-phenyl)-4-diethylamino-benzenesulfonamide 84 N-(2-Benzoyl-4-fluoro-phenyl)-4-methoxy-benzenesulfonamide 85 4-Chloro-N-[4-chloro-2-(pyridine-3-carbonyl)-phenyl]-benzenesulfonamide 86 N-(2-Benzoyl-4-bromo-phenyl)-4-methyl-benzenesulfonamide 87 N-(2-Benzoyl-4-chloro-phenyl)-4-bromo-benzenesulfonamide 88 -[4-Chloro-2-(pyridine-3-carbonyl)-phenyl]-4-methoxy-benzenesulfonamide 89 N-(2-Benzoyl-4-chloro-phenyl)-4-dimethylamino-benzenesulfonamide 90 N-(2-Benzoyl-4-chloro-phenyl)-4-fluoro-benzenesulfonamide 91 4-Chloro-N-[4-chloro-2-(2-fluoro-benzoyl)-phenyl]-benzenesulfonamide 92 N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-4-methoxy-benzenesulfonamide 93 Thiophene-3-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 94 5-Bromo-thiophene-2-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 95 5-Chloro-thiophene-2-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 96 N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-4-nitro-benzenesulfonamide 97 N-[4-Chloro-2-(2-fluoro-benzoyl)-phenyl]-4-methyl-benzenesulfonamide 98 4-Chloro-N-[4-chloro-2-(pyridine-2-carbonyl)-phenyl]-benzenesulfonamide 99 N-(2-Benzoyl-4-chloro-phenyl)-benzenesulfonamide 100 N-[4-(2-Benzoyl-4-chloro-phenylsulfamoyl)-phenyl]-acetamide 101 N-[4-Chloro-2-(pyridine-2-carbonyl)-phenyl]-4-methoxy-benzenesulfonamide 102 N-[4-Chloro-2-(pyridine-2-carbonyl)-phenyl]-4-methyl-benzenesulfonamide 103 N-(2-Benzoyl-4-chloro-phenyl)-4-cyano-benzenesulfonamide 104 4,5-Dibromo-thiophene-2-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 105 N-[4-Chloro-2-(pyridine-3-sulfonyl)-phenyl]-4-nitro-benzenesulfonamide 106 Naphthalene-2-sulfonic acid [4-chloro-2-(pyridine-3-carbonyl)-phenyl]-amide 107 N-(2-Benzoyl-4-chloro-phenyl)-3-bromo-benzenesulfonamide 108 N-(2-Benzoyl-4-chloro-phenyl)-4-methyl-3-nitro-benzenesulfonamide 109 N-[4-Chloro-2-(2-methoxy-benzoyl)-phenyl]-4-nitro-benzenesulfonamide 110 N-(2-Benzoyl-4-chloro-phenyl)-2-trifluoromethyl-benzenesulfonamide 111 5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 112 N-(2-Benzoyl-phenyl)-4-nitro-benzenesulfonamide 113 5-Isoxazol-3-yl-thiophene-2-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 114 N-(2-Benzoyl-phenyl)-4-methyl-benzenesulfonamide 115 Benzo[b]thiophene-3-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 116 N-(4-Chloro-2-phenylsulfanyl-phenyl)-4-isopropoxy-benzenesulfonamide 117 N-(2-Benzenesulfonyl-4-chloro-phenyl)-4-isopropoxy-benzenesulfonamide 118 N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide 119 -[4-Chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide 120 -Isopropoxy-N-[2-(pyridine-4-carbonyl)-4-trifluoromethyl-phenyl] -benzenesulfonamide 121 4-Ethoxy-N-[2-(pyridine-4-carbonyl)-4-trifluoromethyl-phenyl]-benzenesulfonamide N- [5-Chloro-3-(3-fluoro-benzoyl)-pyridin-2-yl] -4-isopropyl-benzenesulfonamide 123 N-[5-Chloro-3-(3-fluoro-benzoyl)-pyridin-2-yl]-4-isopropoxy-benzenesulfonamide N-[5-Chloro-3-(thiophene-2-carbonyl)-pyridi n-2-yl]-4-isopropoxy-benzenesulfonamide 125 5-Oxazol-5-yl-thiophene-2-sulfonic acid [5-chloro-3-(3-fluoro-benzoyl)-pyridin-2-yl]-amide 126 N-[3-(Benzofuran-2-carbonyl)-5-chloro-pyridin-2-yl]-4-isopropoxy-benzenesulfonamide 127 N-(2-Benzoyl-4-trifluoromethyl-phenyl)-4-isopropoxy-benzenesulfonamide 128 N-(3-Benzoyl-pyridin-4-yl)-4-isopropoxy-benzenesulfonamide 129 N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-isopropyl-benzenesulfonamide 130 N-(3-Benzoyl-5-nitro-pyridin-2-yl)-4-isopropoxy-benzenesulfonamide 5-Oxazol-5-yl-thiophene-2-sulfonic acid (3-benzoyl-5-chloro-pyridin-2-yl)-amide 132 N-(2-Benzoyl-4-chloro-phenyl)-4-isopropylami.no-benzenesuIfonamide 133 N-(4-Benzoyl-pyridin-3-yl)-4-isopropyl-benzenesulfonamide 134 N-(4-Benzoyl-pyridin-3-yl)-4-isopropoxy-benzenesulfonamide 135 sT-[4-Chloro-2-(pyridin-3-yloxy)-phenyl]-4-isopropyl-benzenesulfonamide 136 N-(2-Benzoyl-pyridin-3-yl)-4-isopropoxy-benzenesulfonamide 137 N-[3-(3-Fluoro-benzoyl)-pyridin-2-yl]-4-isopropoxy-benzenesulfonamide 138 -[4-Chloro-2-(pyridin-3-yloxy)-phenyl]-4-isopropoxy-benzenesulfonamide 139 4-Isopropoxy-N-[3-(pyridine-4-carbonyl)-pyridin-4-yl]-benzenesulfonamide 140 6-Isopropoxy-pyridine-3-sulfonic acid (3-benzoyl-5-chloro-pyridin-2-yl)-amide 141 6-Isopropoxy-pyridine-3-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide 142 N-[4-Chloro-2-(pyridin-2-ylsulfanyl)-phenyl]-4-isopropyl-benzenesulfonamide 143 N-(2-Benzoyl-phenyl)-4-isopropoxy-benzenesulfonamide [00075] The structural formulas of Examples 7-27, 31-36, and 116-119 of Table 1 are shown in the Examples section. Examples 45-143 (Examples 116-119 are also included below) of Table 1 have the following structural formulas:

O HN~S O HN'S
N 0j" CI
CF3 OrN ~O

45. 46.

O O N+~O
OSO 0 HN"S
O HN
\ J

CI
J
COON
47. 48.

O~ O
H OSO 0 HN~S

N \
I/ OK { \ { ~N / O
N

49. 50.
~SO oS 0 0 HNC \ 0 HN" ( \

{NCF3 51. 52.

0 H OSO 0 HN~S
NlaOA

Cl Cl 53. 54.

\S0 O HN-' (QOk 0 HNC

S-o l:lo cl ct 55. 56.
OSO s 0 HNI 0 HN' N I / SJ N N't-"
Ci CI
57. 58.

OI \S,O 0 HNS

I N /
0 HN "N

cl CI
59. , 60.
O O
OSO HNS
0 HN ( OSO /
I N O
S N / O-l CI CI
61. 62.

OSLO O HNC

0 HN I F3C )1-S O~ I I O
cl N cl 63. 64.
0 0 O HN-' 0 HN' S

la N O
J N /
N cl cl 65. 66.

\\/j 0 HN"
0 HN"
N \ I o 11 N'' N /
I

CI

67. 68.

\0 0 HNC-S I \ I \ S", NH 0 0 N ~O
O- O

69. 70-p F
S S OJT$:c ONTO CI
71. 72.
i\S/ S 0 S/
O HN ' \ IN 0 HN

CI Cl 73. 74.
s ~s O HNC 0 HN \

\ \ O/ Cl CI CI

76.
75.

~~NH

0 O\Sj N
S
O HN \O 0 HN F
I I \ \ I \ F F

CI CI
78.
77.

O HNC O HN
I CI

79. 80.

\\ //
0 HN Cl Cl \ \ / / \
p Cl it IS 1 NH 0 O

81. 82.
\SO

NH O
S/O

\ 1 I / F
Cl 83. 84.

I S

I CI I I

Cl Br 85. 86.
\ 0 0,8 ~S \

\ \ / Br N \ I \ / I
CI
Cl 87. 88.
N

S/O \\S
0 HNC \\ 0 HNC
CI CI

90.
89.

O O \\//
O HNS
F O HN F I L

CI
Cl 91. 92.
S/ \S/ s O HN \- Cs O HN/ ' / Br CI CI

93. 94.
\\// \\//
O HN/s s ' / Cl F O HN IaN+~o CI CI
95. 96.

\\// II
F 0 HN/ O HN-' \ / CI
N

CI
Cl 97. 98.

cI

s O HNC

laNH
II-NH
II \ / i Cl 99 100.

0zJ1 i~ -0 HNC 0 HN-i~ \ /
\ I \ / ~ I N\

Cl Cl 101. 102.
O HN O HN Br N Br CI Cl 103. - 104.

\\// 0 11 s / HNC IaN O H NC 0 \ S +/O N
N
CI Cl 105. 106.

\\// s/ N \
O HNs Br 0 HNC I \ O

Cl Cl 107. 108.

F F
F
\\~~
O
0\\ / s ~NH 0 0 HN/s O
NIl O
Cl CI

109. 110.
%// s \s~
0 HN~s O HN

/ CI
CI -111. 112.
s s _ O HN O O HN/s Cl 114.
113.

O~ 0 0/O
0 HN7S HN"IS
S S \ / ~\
cI cI
115. 116.

NA
\S HN 0 HN o Q I y N\ I \ I

CI CI
117. 118.

Y ~s \\ 0 HN ,O
S O
0 HN/ \

N
N\ \ I F
F F
c' 120.
119.

o\s / S

0 HN/ \ o 0 HNC lay F N N~ \ ( I

F
CI
F F
122.
121.

O HNS O HN
F \ I S
N O \ ! I N
CI CI
123. 124.

~ S j S O HNC

0 HN \ `N O \N

ZI-I ~ I

CI
cI
125. 126.

O HN \\

O

/
F N
F F
127. 128.

129. 130.

\/ 0 iS S O- O ~S
0 HN ` \ \
N
\ \ ` / N 0 HN H
cI
CI
131. 132.

N N
133. 134.

\
/
HN \
O HN
ay %
CNT N
CI
135. 136.

\S/ HN~S

N CNf C!
137. 138.

O\ /0 S
0 HN/ 0 HN' O
N CI
139. 140.

O HN I N \ S \ I/

l, I

CI
CI
141. 142.

/ O
143.

[00076] The following compounds are preferred compounds for use in the method of the invention:

N-(2-Benzoyl-4-chlorophenyl)-4-ethyl-benzenesulfonam-ide;-N-(2-Benzoyl-4-nitrophenyl)-4-ethyl-benzenesulfonamide;
N-(2-Benzoyl-4-bromophenyl)-4-isopropyl-benzenesulfonamide;
N-(2-Benzoyl-4-chlorophenyl)-4-ethoxy-benzenesulfonamide;
N-(2-Benzoyl-4-chlorophenyl)-4-isopropoxy-benzenesulfonamide;
N-(3-Benzoyl-5-chloro-pyri din-2-yl)-4-isopropoxy-benzenesulfonamide;

N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-ethoxy-benzenesulfonamide;
N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isopropyl-benzenesulfonamide;

N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isobutyl-benzenesulfonamide;
N-(3-Benzoyl-5-nitro-pyridin-2-yl)-4-isopropoxy-benzenesulfonamide ;
N- [4-Chloro-2-(pyrimidine-5-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide;
N-(2-Benzoyl-4-nitrophenyl)-4-isopropyl-benzenesulfonamide;
N-(2-Benzoyl-4-nitrophenyl)-4-isopropoxy-benzenesulfonamide;
N-(4-Chloro-2-phenylsulfanyl-phenyl)-4-isopropoxy-benzenesulfonamide;
N-(2-Benzenesulfonyl-4-chloro-phenyl)-4-i sopropoxy-benzenesulfonamide;
N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide;
N-[4-Chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide;
4-Ethoxy-N-[2-(pyridine-4-carbonyl)-4-trifluoromethyl-phenyl]-benzenesulfonamide;
N-[5-Chloro-3-(3-fluoro-benzoyl)-pyridin-2-yl]-4-isopropoxy-benzenesulfonamide;
N-(2-B enzoyl-4-trifluoromethyl-phenyl)-4-i sopropoxy-benzenesulfonamide;
N-(3-Benzoyl-pyridin-4-yl)-4-i sopropoxy-benzenesulfonamide;
N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-isopropyl-benzenesulfonamide;
5-Oxazol-5-yl-thiophene-2-sulfonie acid (3-benzoyl-5-chloro-pyridin-2-yl)-amide;
6-lsopropoxy-pyridine-3-sulfonie acid (3-benzoyl-5-chloro-pyridin-2-yl)-amide;

6-Isopropoxy-pyridine-3-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide;
N-[4-Chl oro-2-(pyridin-2-ylsulfanyl)-phenyl]-4-i sopropyl-benzenesulfonamide; and pharmaceutically acceptable salts, solvates, or hydrates thereof.

Models of Inflammation [00077] In vivo models of inflammation are available which can be used to assess the efficacy of compounds of the invention. For example, leukocyte infiltration upon intradermal injection of a chemokine and compound of the invention into a suitable animal, such as rabbit, mouse, rat, guinea pig or primate (e.g., rhesus macaque) can be monitored (see e.g., Van Damme, J. et al., J. Exp. Med., 176: 59-65 (1992); Zachariae, C.O.C. et al., J. Exp. Med.
171: 2177-2182 (1990); Jose, P.J. et al., J. Exp. Med. 179: 881-887 (1994)).
In one embodiment, skin biopsies are assessed histologically for infiltration of leukocytes (e.g., CCR9' T cells). In another embodiment, labeled cells (e.g., stably transfected cells expressing a mammalian CCR9, labeled with "'In for example) capable of chemotaxis and extravasation are administered to the animal. For example, compound of the invention to be assessed which binds a mammalian CCR9 can be administered, either before, simultaneously with or after a CCR9 ligand or agonist (e.g., TECK) is administered to the test animal. A
decrease of the extent of infiltration in the presence of the compound of the invention as compared with the extent of infiltration in the absence of said compound is indicative of inhibition.

[00078] As described herein, CCR9 is selectively expressed on memory lymphocytes which home to mucosal sites (e.g., CLA" e a4P7h' CD4{ lymphocytes). Thus, animal models of inflammatory diseases of the mucosa (e.g., respiratory tract, urogenital tract, alimentary canal and associated organs and tissues (e.g., pancreas, liver, gall bladder)) can be used to assess the therapeutic efficacy of CCR9 inhibiting compounds. For example, the therapeutic efficacy of a compound of the invention can be studied in the cotton-top tamarin model of inflammatory bowel disease (Podolsky, D.K., et al., J. Clin. Invest. 92:372-380 (1993)). The CD45RBH'/SCID model provides a mouse model with similarity to both Crohn's disease and ulcerative colitis (Powrie, F. et al., Inamutinity, 1: 553-562 (1994)).
Therapeutic efficacy in this model can be assessed, for example, by using parameters such as inhibition of recruitment of'11In-labeled cells to the colon and reduction in the number of CD4} T
lymphocytes in the lamina propria of the large intestine after administration (e.g., intravenous (i.v.), intraperitoneally (i.p.) and per oral (p.o.)) of a compound.

Methods of Therapy [00079] Inhibition of at least one function characteristic of a mammalian CCR9 protein according to the present invention provides an effective and selective way of inhibiting receptor-mediated functions. Once lymphocytes are recruited to a site, other leukocyte types, such as monocytes, may be recruited by secondary signals. Thus, compounds which can inhibit CCR9 function (e.g., compounds of the invention) can be used to inhibit leukocyte function (e.g., leukocyte infiltration including recruitment and/or accumulation).

[00080] In one aspect, the present invention provides a method of inhibiting an inflammatory response in a subject, comprising administering an effective amount of a compound of the invention which inhibits mammalian CCR9 function to a subject in need of such therapy. In one embodiment, an effective amount of a compound which inhibits one or more functions of a mammalian CCR9 protein (e.g., a human CCR9) is administered to a subject to inhibit (i.e., reduce or prevent) inflammation. Preferred compounds of the invention, inhibit an inflammatory response in a subject by inhibiting (i.e., reduce or prevent) binding of ligand (e.g. TECK) to CCR9. As a result, one or more inflammatory processes, such as leukocyte emigration, chemotaxis, exocytosis (e.g., of enzymes) or inflammatory mediator release, is inhibited. For example, leukocytic infiltration of inflammatory sites (e.g., in a inflamed mucus membrane (e.g., colon, small intestine)) can be inhibited according to the present method. In another embodiment, an effective amount of a compound of the invention which inhibits one or more functions of a mammalian CCR9 protein (e.g., a human CCR9) is administered to a subject to inhibit (i.e., reduce or prevent) CCR9-mediated homing of leukocytes. In particular embodiments, an effective amount of a compound which binds to human CCR9 and/or an effective amount of a compound which binds to human TECK
is administered to a subject in need thereof.

[00081] Thus, the invention relates to a method of treating a subject having an inflammatory disease, comprising administering an effective amount of a compound of the invention that antagonizes CCR9 function. In a particular embodiment, the subject has an inflammatory bowel disease, such as Crohn's disease or colitis. Treatment includes therapeutic or prophylactic treatment. Treatment, in accordance with the method, can prevent disease or reduce the severity of disease in whole or in part.

[00082) The invention also relates to a method of inhibiting CCR9-mediated homing of leukocytes in a subject, comprising administering an effective amount of a compound of the invention that antagonizes CCR9 function, for example, the homing of leukocytes to mucosal sites can be inhibited. Immigration of circulating leukocytes into organs or tissue (e.g., intestine) and/or local recruitment of lymphocytes within an organ or tissue (e.g., IEL, LPL) can be inhibited in accordance with the method.

[00083] The term "subject" is defined herein to include animals such as mammals, including, but not limited to, primates (e.g., humans), cows, sheep, goats, horses, dogs, cats, rabbits, guinea pigs, rats, mice or other bovine, ovine, equine, canine, feline, rodent or murine species. A "subject in need of treatment to inhibit CCR9 function" is a subject in whom a beneficial therapeutic or prophylactic effect can be achieved by inhibiting CCR9 function.
Examples include subjects with one of the diseases or conditions described herein.

[00084] Diseases and conditions associated with inflammation and/or infection can be treated using the methods described herein. In a preferred embodiment, the disease or condition is one in which the actions of lymphocytes, particularly lymphocytes which home to mucosal tissues, are to be inhibited or promoted for therapeutic (including prophylactic) purposes. In a particularly preferred embodiment, the inflammatory disease or condition is a T cell-mediated disease or condition.
[00085] Examples of inflammatory diseases associated with mucosal tissues which can be treated according to the present method include mastitis (mammary gland), vaginitis, cholecystitis, cholangitis or pericholangitis (bile duct and surrounding tissue of the liver), chronic bronchitis, chronic sinusitis, asthma, and graft versus host disease (e.g., in the gastrointestinal tract). As seen in Crohn's disease, inflammation often extends beyond the mucosal surface, accordingly chronic inflammatory diseases of the lung which result in interstitial fibrosis, such as interstitial lung diseases (ILD) (e.g., idiopathic pulmonary fibrosis, or ILD associated with rheumatoid arthritis, or other autoimmune conditions), hypersensitivity pneumonitis, collagen diseases, sarcoidosis, and other idiopathic conditions can be amenable to treatment. Pancreatitis and insulin-dependent diabetes mellitus are other diseases which can be treated using the present method.

[00086] In a particularly preferred embodiment, diseases which can be treated accordingly include inflammatory bowel disease (IBD), such as ulcerative colitis, Crohn's disease, ileitis, Celiac disease, nontropical Sprue, enteritis, enteropathy associated with seronegative arthropathies, microscopic or collagenous colitis, eosinophilic gastroenteritis, or pouchitis resulting after proctocolectomy, and ileoanal anastomosis.

[00087] Additional diseases or conditions, including chronic diseases, of humans or other species which can be treated with compounds of the invention that inhibit of CCR9 function, include, but are not limited to:

[00088] = inflammatory or allergic diseases and conditions, including systemic anaphylaxis or hypersensitivity responses, drug allergies (e.g., to penicillin, cephalosporins), insect sting allergies; psoriasis and inflammatory dermatoses such as dermatitis, eczema, atopic dermatitis, allergic contact dermatitis, urticaria; vasculitis (e.g., necrotizing, cutaneous, and hypersensitivity vasculitis); spondyloarthropathies; scleroderma;
respiratory allergic diseases such as asthma, allergic rhinitis;

[00089] = autoimmune diseases, such as arthritis (e.g., rheumatoid arthritis, psoriatic arthritis), multiple sclerosis, systemic lupus erythematosus, myasthenia gravis, juvenile onset diabetes, glomerulonephritis and other nephritides, autoimmune thyroiditis, Behcet's disease;
[00090] = graft rejection (e.g., in transplantation), including allograft rejection or graft-versus-host disease; -[00091] = other diseases or conditions in which undesirable inflammatory responses are to be inhibited can be treated, including, but not limited to, atherosclerosis, restenosis, myositis (including polymyositis, dermatomyositis).

Modes of Administration [00092] The compound can be administered as a neutral compound or as a salt.
Salts of compounds containing an amine or other basic group can be obtained, for example, by contacting the compound with a suitable organic or inorganic acid, such as hydrogen chloride, hydrogen bromide, acetic acid, perchloric acid and the ]ike. Compounds with a quaternary ammonium group also contain a counteranion such as chloride, bromide, iodide, acetate, perchlorate and the like. Other examples of such salts include hydrochlorides, hydrobromides, sulfates, methanesulfonates, nitrates, maleates, acetates, citrates, fumarates, tartrates [e.g. (+)-tartrates, (-)-tartrates or mixtures thereof including racemic mixtures], succinates, benzoates and salts with amino acids such as glutamic acid.

[00093] Salts of compounds containing a carboxylic acid or other acidic functional group can be prepared by reacting with a suitable base. Such a pharmaceutically acceptable salt may be made with a base which affords a pharmaceutically acceptable cation, which includes alkali metal salts (especially sodium and potassium), alkaline earth metal salts (especially calcium and magnesium), aluminum salts and ammonium salts, as well as salts made from physiologically acceptable organic bases such as trimethylamine, triethylamine, morpholine, pyridine, piperidine, picoline, dicyclohexylamine, N,N'-dibenzylethylenediamine, 2-hydroxyethylamine, bis-(2-hydroxyethyl)amine, tri-(2-hydroxyethyl)amine, procaine, dibenzylpiperidine, N-benzyl-P-phenethylamine, dehydroabietylamine, N,N'-bisdehydroabietylamine, glucamine, N-methylglucamine, collidine, quinine, quinoline, and basic amino acid such as lysine and arginine. These salts may be prepared by methods known to those skilled in the art.

[00094] Salts of acidic functional groups contain a countercation such as sodium, potassium and the like.

[00095] Certain compounds described herein and their salts may also exist in the form of solvates, for example hydrates, and the present invention includes each solvate and mixtures thereof.

[00096] Certain compounds described herein may exist in different stable conformational forms which may be separable. Torsional asymmetry due to restricted rotation about an asymmetric single bond, for example because of steric hindrance or ring strain, may permit separation of different conformers. The present invention includes each conformational isomer of these compounds and mixtures thereof.

[00097] Certain compounds described herein may exist in zwitterionic form. The present invention includes each zwitterionic form of these compounds and mixtures thereof.
[00098] Certain compounds described herein and their salts may exist in more than one crystal form. Polymorphs of these compounds form part of this invention and may be prepared by crystallization of the compound under different conditions, for example, by using different solvents or different solvent mixtures for recrystallization; by crystallization at different temperatures; or by various modes of cooling, ranging from very fast to very slow cooling during crystallization. Polymorphs may also be obtained by heating or melting the compound followed by gradual or fast cooling. The presence of polymorphs may be determined by solid probe nmr spectroscopy, it spectroscopy, differential scanning calorimetry, powder X-ray diffraction or such other techniques.

[00099] The language an "effective amount" or "pharmaceutically effective amount" is intended to include an amount which is sufficient to ameliorate a disease or condition and prevent its further progression or ameliorate the symptoms associated with the disease or condition. Such an amount can be administered prophylactically to a patient thought to be susceptible to development of a disease or condition. Such amount when administered prophylactically to a patient can also be effective to prevent or lessen the severity of the mediated condition. Such an amount is intended to include an amount which is sufficient to modulate a CCR9 receptor-mediated disease or condition. Conditions mediated by receptors include all of the diseases or conditions described herein. Although the amount to be administered to a subject will, of course, be determined by a physician, in the light of all the relevant circumstances, an "effective amount" typically ranges between about 0.01 mg/kg/day to about 100 mg/kg/day, preferably between about 0.5 mg/kg/day to about 50 mg/kg/day.
[000100] The compounds described herein, and the pharmaceutically acceptable salts, solvates and hydrates thereof, have valuable pharmacological properties and can be used in pharmaceutical preparations containing the compound or pharmaceutically acceptable salts thereof, in combination with a pharmaceutically acceptable carrier or diluent.
They are useful as therapeutic substances in preventing or treating diseases mediated by CCR9 receptors, such as inflammatory diseases, in human or non-human animals. Suitable pharmaceutically acceptable carriers include inert solid fillers or diluents and sterile aqueous or organic solutions. The active compound will be present in such pharmaceutical compositions in amounts sufficient to provide the desired dosage amount in the range described herein.
Techniques for formulation and administration of the compounds of the instant invention can be found in Remingtonn: the Science and Practice of Pharmacy, 19`h edition, Mack Publishing Co., Easton, PA (1995).

[000101] For oral administration, the compound or salts thereof can be combined with a suitable solid or liquid carrier or diluent to form capsules, tablets, pills, powders, syrups, solutions, suspensions and the like.

[000102] The tablets, pills, capsules, and the like may also contain a binder such as gum tragacanth, acacias, corn starch or gelatin; excipients such as dicalcium phosphate; a disintegrating agent such as corn starch, potato starch, alginic acid, a lubricant such as magnesium stearate; and a sweetening agent such as sucrose lactose or saccharin. When a dosage unit form is a capsule, it may contain, in addition to materials of the above type, a liquid carrier such as a fatty oil.

[000103] Various other materials may be present as coatings or to modify the physical form of the dosage unit. For instance, tablets may be coated with shellac, sugar or both. A
syrup or elixir may contain, in addition to the active ingredient, sucrose as a sweetening agent, methyl and propylparabens as preservatives, a dye and a flavoring such as cherry or orange flavor.

[000104] The active compounds can also be administered intranasally as, for example, liquid drops or spray. For oral or nasal inhalation, the compounds for use according to the present invention are conveniently delivered in the form of a dry powder inhaler, or an aerosol spray presentation from pressurized packs or a nebuliser, with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas. In the case of pressurized aerosol the dosage unit may be determined by providing a valve to deliver a metered amount. Capsules and cartridges of gelatin for use in an inhaler or insufflator may be formulated containing a powder mix of the compound and a suitable powder base such as lactose or starch.
[000105] For parental administration the compounds of the present invention, or salts thereof can be combined with sterile aqueous or organic media to form injectable solutions or suspensions. For example, solutions in sesame or peanut oil, aqueous propylene glycol and the like can be used, as well as aqueous solutions of water-soluble pharmaceutically-acceptable salts of the compounds. Dispersions can also be prepared in glycerol, liquid polyethylene glycols and mixtures thereof in oils. Under ordinary conditions of storage and use, these preparations contain a preservative to prevent the growth of microorganisms.
[000106] The pharmaceutical forms suitable for injectable use include sterile aqueous solutions or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersions. In all cases, the form must be sterile and must be fluid to the extent that each syringability exists. It must be stable under the conditions of manufacture and storage and must be preserved against any contamination. The carrier can be solvent or dispersion medium containing, for example, water, ethanol, polyol (e.g.
glycerol, propylene glycol and liquid polyethylene glycol), propylene glycol and liquid polyethylene glycol), suitable mixtures thereof, and vegetable oils. The injectable solutions prepared in this manner can then be administered intravenously, intraperitoneally, subcutaneously, or intramuscularly, with intramuscular administration being preferred in humans.
[000107] The compounds may also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter or other glycerides.

[000108] In addition, to the formulations described previously, the compounds may also be formulated as a depot preparation. Such long acting formulations may be administered by implantation, for example, subcutaneously or intramuscularly or by intramuscular injection.
Thus, for example, as an emulsion in an acceptable oil, or ion exchange resins, or as sparingly soluble derivatives, for example, as sparingly soluble salts.

[000109] The effective dosage of active ingredient employed may vary depending on the particular compound employed, the mode of administration, the condition being treated and the severity of the condition being treated.

[000110] The compositions are formulated and administered in the same general manner as detailed herein. The compounds of the instant invention may be used effectively alone or in combination with one or more additional active agents depending on the desired target therapy. Combination therapy includes administration of a single pharmaceutical dosage formulation which contains a compound described herein and one or more additional active agents, as well as administration of the compound and each active agent in its own separate pharmaceutical dosage formulation. For example, a compound described herein or salt thereof can be administered to the patient together in a single oral dosage composition such as a tablet or capsule, or each agent administered in separate oral dosage formulations. Where separate dosage formulations are used, a compound of the invention and one or more additional active agents can be administered at essentially the same time, i.e., concurrently, or at separately staggered times, i.e., sequentially; combination therapy is understood to include all these regimens.

[000111] An effective amount of the compounds described herein can be used for the preparation of a medicament useful for treating a disease mediated by CCR9 receptors, such as an inflammatory disease, and for treating, preventing or reducing the risk of developing a disease mediated by CCR9 receptors, such as an inflammatory disease, in mammals, particularly in humans.

[000112] Preferably compounds of the invention or pharmaceutical formulations containing these compounds are in unit dosage form for administration to a mammal. The unit dosage form can be any unit dosage form known in the art including, for example, a capsule, an IV bag, a tablet, or a via]. The quantity of active ingredient (viz., a compound of Structural Formula I or salts thereof) in a unit dose of composition is an effective amount and may be varied according to the particular treatment involved. It may be appreciated that it may be necessary to make routine variations to the dosage depending on the age and condition of the patient. The dosage will also depend on the route of administration which may be by a variety of routes including oral, aerosol, rectal, transdermal, subcutaneous, intravenous, intramuscular, intraperitoneal and intranasal.

[000113] Pharmaceutical formulations of the invention are prepared by combining (e.g., mixing) an effective amount of a compound of the invention together with a pharmaceutically acceptable carrier or diluent. The present pharmaceutical formulations are prepared by known procedures using well known and readily available ingredients.
[000114] In making the compositions of the present invention, the active ingredient will usually be admixed with a carrier, or diluted by a carrier, or enclosed within a carrier which may be in the form of a capsule, sachet, paper or other container. When the carrier serves as a diluent, it may be a solid, lyophilized solid or paste, semi-solid, or liquid material which acts as a vehicle, or can be in the form of tablets, pills, powders, lozenges, elixirs, suspensions, emulsions, solutions, syrups, aerosols (as a solid or in a liquid medium), or ointment, containing, for example, up to 10% by weight of the active compound. The compounds of the present invention are preferably formulated prior to administration.

[000115] For the pharmaceutical formulations any suitable carrier known in the art can be used. In such a formulation, the carrier may be a solid, liquid, or mixture of a solid and a liquid.

[000116] Advantageously, compositions containing the compounds of the invention or the salts thereof may be provided in dosage unit form, each dosage unit containing from about 5% to about 95%, preferably about 20% to about 80%, of a compound of the invention, although it will, of course, readily be understood that the amount of the compound or compounds actually to be administered will be determined by a physician, in the light of all the relevant circumstances.

[000117] Powders and tablets preferably contain from about 1 to about 99 weight percent of the active ingredient which is the novel compound of this invention. Suitable solid carriers are magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatin, tragacanth, methyl cellulose, sodium carboxymethyl cellulose, low melting waxes, and cocoa butter.
[000118] The following pharmaceutical formulations 1 through 8 are illustrative only and are not intended to limit the scope of the invention in any way. "Active Ingredient", refers to a compound according to Structural Formula I or salts thereof.

Formulation 1 Hard gelatin capsules are prepared using the following ingredients:
Quantity (mg/capsule) Active Ingredient 250 Starch, dried 200 Magnesium stearate 10 Total 460 mg Formulation 2 A tablet is prepared using the ingredients below:
Quantity m tablet Active Ingredient 250 Cellulose, microcrystalline 400 Silicon dioxide, fumed 10 Stearic acid 5 Total 665 mg [000119] The components are blended and compressed to form tablets each weighing 665 mg Formulation 3 An aerosol solution is prepared containing the following components:
Weight Active Ingredient 0.25 Ethanol 25.75 Propellant 22 (Chlorodifluoromethane) 74.00 Total 100.00 [000120] The Active Ingredient is mixed with ethanol and the mixture added to a portion of the propellant 22, cooled to 30 C and transferred to a filling device. The required amount is then fed to a stainless steel container and diluted with the remainder of the propellant. The valve units are then fitted to the container.

Formulation 4 Tablets, each containing 60 mg of Active ingredient, are made as follows:

Active Ingredient 60 mg Starch 45 mg Microcrystalline cellulose 35 mg Polyvinylpyrrolidone (as 10% solution in water) 4 mg Sodium carboxymethyl starch 4.5 mg Magnesium stearate 0.5 mg Talc 111119 Total 150 mg [000121] The Active Ingredient, starch and cellulose are passed through a No.
45 mesh U.S. sieve and mixed thoroughly. The aqueous solution containing polyvinylpyrrolidone is mixed with the resultant powder, and the mixture then is passed through a No.
14 mesh U.S.
sieve. The granules so produced are dried at 50 C and passed through a No. 18 mesh U.S.
sieve. The sodium carboxymethyl starch, magnesium stearate and talc, previously passed through a No. 60 mesh U.S. sieve, are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 150 mg.

Formulation 5 Capsules, each containing 80 mg of Active Ingredient, are made as follows:
Active Ingredient 80 mg Starch 59 mg Microcrystalline cellulose 59 mg Magnesium stearate 2 mg Total 200 mg [000122] The Active Ingredient, cellulose, starch, and magnesium stearate are blended, passed through a No. 45 mesh U.S. sieve, and filled into hard gelatin capsules in 200 mg quantities.

Formulation 6 Suppositories, each containing 225 mg of Active Ingredient, are made as follows:
Active Ingredient 225 mg Saturated fatty acid glycerides 2,000 mg Total 2,225 mg [000123] The Active Ingredient is passed through a No. 60 mesh U.S. sieve and suspended in the saturated fatty acid glycerides previously melted using the minimum heat necessary. The mixture is then poured into a suppository mold of nominal 2g capacity and allowed to cool.

Formulation 7 Suspensions, each containing 50 mg of Active Ingredient per 5 mL dose, are made as follows:
Active Ingredient 50 mg Sodium carboxymethyl cellulose 50 mg Syrup 1.25 mL
Benzoic acid solution 0.10 mL
Flavor q.v.
Color q.v.
Purified water to total 5 mL

[000124] The Active Ingredient is passed through a No. 45 mesh U.S. sieve and mixed with the sodium carboxymethyl cellulose and syrup to form a smooth paste. The benzoic acid solution, flavor and color are diluted with a portion of the water and added, with stirring.
Sufficient water is then added to produce the required volume.

Formulation 8 An intravenous formulation may be prepared as follows:

Active Ingredient 100 mg Isotonic saline 1,000 mL

[000125] The solution of the above materials generally is administered intravenously to a subject at a rate of 1 mL per minute.

i3 EXAMPLES

1. General Synthesis Pr Pr\
HNC NH O

Xt alkyl lithium Xi Art 11 A + N Ary I~1 A
X2 X2, x3 Ay ~0 X3 At XXVI. XXVII. XXVIII.

amine deprotection Xy Art A +
X1 CYO --Ar2 \X3 Ay XXIX. m.
% 0 0 ll Are/ NH 0 method I or method 2 xy Art X3 At XXXI.
Scheme I: General synthesis of diaryl methanones.

[000126] The sulfonamides of the invention can be synthesized by treating a protected aromatic amine (XXVI) or a protected heteroaromatic amine (XXVI), such as an aminobenzene, an aminopyradine, an aminopyrimidine, an aminopyridazine, an aminopyrazine, an aminotriazine or an aminotetrazine, with an alkyl lithium.
Typically, the amino group of the aromatic amine or heteroaromatie amine is protected with protecting group which is stable under basic condition, such as a tert-butoxycarbonyl (BOC) group. The aromatic amine or heteroaromatic amine is dissolved in an aprotic solvent, preferably an ether. The solution is then cooled to about -50 C to about -100 C and about 1 equ. to about 2.5 equ. of alkyl lithium (e.g., n-butyl lithium, s-butyl lithium or t-butyl lithium) is added slowly to the reaction mixture. The temperature of the reaction mixture is allowed to increase to about -25 C to about 25 C. After about 5 min. to abou 45 min., about 1 equ.
to about 1.5 equ. of a Weinreb amide (XXVII), such as a N-methoxy-N-methyl-benzamide or a N-methoxy-N-methyl-isonicotinainide, dissolved in an aprotic solvent is added to the reaction mixture. The reaction is allowed to continue stirring until the protected aromatic amine (XXVI) or protected heteroaromatic amine (XXVI) is consumed (typically, for about 0.5 hr to about 3 hr at about 15 C to about 35 C). The reaction is monitored by thin layer chromatography (tlc) to determine when the aromatic amine (XXVI) or heteroaromatic amine (XXVI) has been consumed. When the reaction is complete, it is quenched with an acidic aqueous solution to yield compound XXVIII.

[000127] After the amino group of compound XXVIII has been deprotected to yield compound XXIX, compound XXIX is converted to a sulfonamide by using one of two alternative methods. In method 1, compound XXIX is dissolved in an aprotic solvent and the solution is cooled to about -25 C to about 10 C and about 1 equ. to about 1.5 equ. of NaH is added to the mixture. After about 1 min. to about 15 min., about I equ. to about 1.5 equ. of sulfonyl chloride (XXX) dissolved in an aprotic solvent is added to the reaction mixture. An additional, amount of up to about 0.5 equ. NaH may be added to the reaction mixture. The reaction is stirred at about 15 C to about 30 C until the reaction is complete as indicated by tlc (typically, about 1 hr to about 3 hr). The reaction is quench by addition of water to yield sulfonamide (XXXI).
[000128] In the second method of forming sulfonamide (XXXI), compound XXIX is dissolved in an aprotic solvent and the mixture is cooled to about -10 C to about 10 C. An excess amount of sodium bis(trimethylsilyl)amide (typically, about 1.5 equ. to about 3 equ.) in an aprotic solvent is added to the solution, and the reaction is allowed to stir for about 10 min. to about 45 min. A solution of about 1 equ. to about 2 equ. of sulfonyl chloride (XXX) in an aprotic solvent is added to the reaction mixture and the reaction is allowed to warm up to about 15 C to about 30 C and is stirred for about 6 hr to about 24 hr. The reaction is quenched with an acidic water solution to yield sulfamide (XXXI).

H. General Synthesis of N-(2-Benzoyl-Phenyl)-Arylsulfonamides and N-(2-Benzoyl-Phenyl)-Heteroarylsulfonamides O NHZ O NHZ Br HO A + (H HCl Procedure A N A +

O O
Procedure B j \ + A 1 \s IB
Cl/ R7 O

Procedure C
orD Y J \
I B A

Scheme II: Synthesis of N-(2-Benzoyl-Phenyl)-Benzenesulfonamides and N-(2-Benzoyl-Phenyl)-Heteroarylsulfonamides.

Procedure A (Synthesis of Weinreb amides):

[000129] A substituted anthranilic acid (24 mmol) was dissolved in acetonitrile (200 mL)..1.05 equivalents of N,O dimethylhydroxylamine hydrochloride, 1.05 equivalents of EDC, 0.05 equivalents of dimethylaminopyridine, and 1.0 equivalent of triethylamine were added and the reaction was stirred at room temperature overnight. The acetonitrile was removed by rotary evaporation and the residue was partitioned between ethyl acetate and water. The organic layer was washed with brine then concentrated to a residue.
The residue was chrornatographed on silica gel (ethyl acetate as eluent) to give the product. Typical yields are 70-90%.

The following compounds were prepared using Procedure A:

Example 1: 2-Amino-5-bromo-N-methoxy-N-methyl-benzaniide [000130] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 259 (M+H+). 'H NMR (Bruker 300 MHz, CDC13, shifts relative to the solvent peak at 7.24 ppm) 6 7.5 (s, 1H) 6 7.23 (d, 1H) 8 6.58 (d, 1H) 6 4.68 (br s, 2H) 8 3.55 (s, 3H) 6 3.41 (s, 3H).

Example 2: 2-Amino-N-methoxy-N-methyl-5-nitro-benzamide [000131] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 226 (M+H+). 'H NMR (CDC13, shifts relative to the solvent peak at 7.24 ppm) fi 8.5 (s, 11-1), 58.1(d,1H)56.7(d,11-1)S3.6(s,3H)53.4(s,3H).

Example 3: . 2-Amino-5-chloro-N-methoxy-N-methyl-benzamide [000132] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 215. (M+H{). IH NMR (Bruker 300 MM, CDC13, shifts relative to the solvent peak at 7.24 ppm) S 7.4 (s, I H) S 7.15 (m, 1H) 8 6.65 (d, I H) 8 3.6 (s, 3H) 8 3.28 (s, 311).
Procedure B (General synthesis of substituted 2-aminobenzophenones):

[000133] A substituted Weinreb amide (10 mmol) and a substituted bromobenzene (10 mmol) were dissolved in THE under nitrogen. The reaction mixture was cooled to using a liquid nitrogen/diethyl ether bath. n-BuLi (21 mmol, 1.6 M in cyclohexanes) was introduced via syringe over a period of twenty minutes. The reaction mixture was allowed to warm to -70 C and then quenched by adding of 21 mL of 1 N HCl. The reaction mixture was partitioned between ethyl acetate and saturated sodium bicarbonate. The organic layer was washed with saturated sodium chloride, then concentrated to a residue. The residue was chromatographed on silica gel using 1:1 ethyl acetate:hexanes to give the product. Typical yields are 30-60%.

The following compounds were prepared using Procedure B:

Example 4: (2-Amino-5-bromo-phenyl)-phenyl-methanone [000134] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 276 (M+H+). IH NN/M (Bruker 300 MI-1z , CDC13, shifts relative to the solvent peak at 7.24 ppm) S 7.2-7.8 (m, 614) S 6.85 (d, 2H) S 6.2 (br s, 2H).

Example 5: (2-Amino-5-nitro-phenyl)-(3-trifluoromethyl-phenyl)-methanone [000135] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 311 (M+H').'H NAIR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm) S 7.6-8.4 (m, 5 H) S 6.75 (d, 2 H) b 7.0 (br s, 2H).

Example 6: (2-Amino-5-chloro-phenyl)-mm-tolyl-methanone [000136] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 246. (M+H+). 'H NMR (Bruker 300 MHz, CDC13, shifts relative to the solvent peak at 7.24 ppm) S 7.25-7.5 (m, 5H) 6 6.8 (d, 2H) b 2.4 (s, 3H).

Procedure C (General synthesis of N-(2-benzoyl-phenyl)-benzenesulfonamides):
[000137] A substituted 2-aminobenzophenone (1 mmol) was dissolved in 5 mL of pyridine. A substituted sulfonyl chloride (1.3 mmol) and dimethlarninopyri dine (10 mg) were added to the 2-aminobenzophenone solution. The reaction mixture was heated to 110 C for 2 hours. The solvent was evaporated under a stream of nitrogen and the product was isolated by reverse phase HPLC using the method given below. Typical yields are 60-80%.
General Method for HPLC Purification of N-(2- ben zo-yl-plienyl)-benzenesulfonamides:
[000138] A crude N-(2-benzoyl-phenyl)-benzenesulfonamides wars dissolved in 1 mL
of MeOH (or MeOHIDCM) and filtered through a 0.45 micron filter. The solution was then *
injected (50-75 mg/injection) to a HPLC/MS system equipped with Waters 2700.
Sample Manager auto-injector. Waters 600 Controller and Pumps, Waters 996 Diode Array detector, * *
Micro Mass Platform LCZ mass spectrometer and Gilson FC-204 fraction collector. Solvents *
A and B were used for gradient elution of the purified compound using Phenomenex Luna 15 micron, C18(2) 100A, 100 X 21.2 mm column at 20 mUmin flow rate.
Solvent A: 99% Water/1% CH.CN/0.1 % Formic Acid Solvent B: 95% CH3CN/5% Water/0.1% Formic Acid *Trademark The gradients were programmed according to their analytical scale HPLC
retention time (to,,,,) which was obtained by running a linear gradient of 0%B to 100%B in A in 3.5 min on a Phenomenex Luna 5 micron C18(2) 50X4.6 mm column at 3.5 mIJmin.

[000139] Linear mixing of 0% of B to X% of B in A was used according to the following formula with some adjustments for some compounds.
X=t,~nx95/3.5+15 [000140] About 15 mL to 25 mL size fractions were collected based on mass triggered collection. They were combined according to their purities based on mass spectral pattern of the fractions.

The following examples were prepared using Procedure C:

Example 7: N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-4-nitro-benzenesulfonamide NH O

)::
OzN /

CI
[000141] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 451 (M+H{). 1H NMR (Broker 300 MHz ,CDC13, shifts relative to the solvent peak at 7.24 ppm) 810.0 (s, 1H) 8 8.0-8.4 (dd, 4H) 6 7.8 (d, I H) 8 7.38-7.58 (m, 6H).

Example 8: Thiophene-2-sulfonic acid (2-benzoyl-4-chloro-phenyl)-amide S~ /I/
s NH O
J
J

Ci [000142] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 378 (M+H+). 1H NMR (Bruker 300 MHz ,CDC13, shifts relative to the solvent peak at 7.24 ppm) 8 10.0 (s, lil) 6 7.85 (d, 1H) 8 7.4-7.7 (m, 9 H) 8 6.85 (d, 1H).

Example 9: N-(2-BenzoyI-4-chloro-phenyl)-4-iodo-benzenesulfonamide NH o CI
[000143] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 498 (M+H+).'H NMR (Bruker 300 MHz ,CDC13, shifts relative to the solvent peak at 7.24 ppm) S 9.7 (s, 111) S 7.3-7.8 (m, 12H).

Example 10: N-(2-Benzoyl-4-chloro-phenyl)-4-chloro-benzenesulfonamide o NH O
CI J \ I

CI
[000144) LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 406 (M+W).'H NMR (Bruker 300 MHz ,CDC13, shifts relative to the solvent peak at 7.24 ppm) S 9.65 (s, 1H) 8 7.2-7.8 (m, 12H).

Example 11: N-(2-Benzoyl-4-chloro-phenyl)-4-tert-butyl-benzenesulfonamide NH O

I I
CI

[000145] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 428 (M+H}). 1H NMR (CDC13, shifts relative to the solvent peak at 7.24 ppm) 8 9.9 (s, 11-1) 8 7.2-7.8 (m, 12H), 81.18 (s, 9H).

Example 12: N-(2-Benzoyl-4-chloro-phenyl)-4-propyl-benzenesulfonamide \S 0 NH O
CI
[000146] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 414 (M+lr). 111 NMR (Broker 300 NH-1z, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 8 9.9 (s, 1H) 8 7.0-7.8 (m, 121-1), 8 2.42 (m, 2H) 81.5 (m, 2H) 6 0.92 (m, 311).

Example 13: N-(2-Benzoyl-4-chloro-phenyl)-4-ethyl-benzenesulfonamide s~o NH O

CI
[000147] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 400 (M+H}). 1H NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm) 6 9.9 (s, 11-1) 8 7.0-7.8 (m, 12H), 8 2.42 (t, 211) 8 0.92 (d, 3H).

Example 14: N-(2-Benzoyl-4-nitro-phenyl)-4-ethyl-benzenesulfonamide s o \ \N" O

[000148] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 411 (M+H+). 1H NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm) 810.6 (s, 1H) 8 8.2-8.45 (m, 2H) 6 7.2-7.9 (m, 10H), 8 2.6 (q, 2H) 8 1.05 (t, 31-1).
Example 15: N-(2-Benzoyl-4-chloro-phenyl)-4-isopropyl-benzenesulfonamide NH O

[000149] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 414 (M+W). 1H NMR (Broker 300 MHz , CDCl3, hifts relative to the solvent peak at 7.24 ppm) 8 9.85 (s, 1H) 8 7.0-7.8 (.m, 12H), S 2.8 (m, 1H) 8 1.03 (d, 6H).

Example 16: N-(2-Benzoyl-4-bromo-phenyl)-4-ethyl-benzenesulfonamide 0o \NH O
S

M f Br [000150] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 444 (M+W). 'H NMR (Broker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm) b 9.8 (s, 11-1), S 7.38-7.8 (m, IOH) i 7.08 (d, 2H) b 2.47 (q, 2H) S 1,1 (t, 3H).

Example 17: N-(2-Benzoyl-4-bromo-phenyl)-4-methoxy-benzenesulfonamide \

Br [000151] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 446 (M+H' ). 'H NMR Broker 300 MHz , (CDC13, shifts relative to the solvent peak at 7.24 ppm) S 9.61 (s, 111) 6 7.2-7.8 (m, 10 H), 6 6.64 (d, 2H) S 3.78 (s, 311).

Example 18: N-(2-Benzoyl-4-bromo-phenyl)-4-isopropyl-benzenesulfonamide NH O

Br [000152] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 459 (M+l-1+). 1H NMR (Broker 300 MHz, CDC13, shifts relative to the solvent peak at 7.24 ppm) 6 9.9 (s, 111), 6 7.28-7.8 (m, 1011) 6 7.16 (d, 2H), 6 2.8 (m, 111) 61.08 (d, Ili).
Example 19: 4-Ethyl-N-[4-nitro-2-(3-trifluoromethyl-benzoyl)-phenyl]-benzenesulfonamide \o \NH 0 I I

[000153] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 479 (M+H+). 111 NMR (Broker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm) 610.9 (s, 1H), 6 8.4 (m, 2H) 6 7.6-8.0 (m, 6 H) 6 7.28 (m, 2 H) S
2.62 (q, 2H) 1.09 (t, 3H).

Example 20: N-[4-Chloro-2-(3-methyl-benzoyl)-phenyl]-4-ethyl-benzenesulfonamide \NH O
CI

[000154] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 414 (M+H'). 'H NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm) S 9.8 (s, 1H) S 7.0-7.9 (m, 11H) 6 2.48 (q, 2H) 6 2.39 (s, 31-1) S
1.13 (t, 3H).
Example 21: N-(2-Benzoyl-4-bromo-phenyl)-4-chloro-benzenesulfonamide NH O

CI ( ~ I \
Br [000155] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 450 (M+H+). 'H NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm) 6 9.7 (s, 1 H), S 7.2-8.0 (m, 12H).

Procedure D : (Alternate synthesis of N-(2-benzoyl-phenyl)-benzenesulfonamides):

[000156] A solution of substituted 2-aminobenzophenone (0.5 mmol), sulfonyl chloride (0.7 mmol), and N-methylmorpholine (0.9 mmol) in dichloromethane (5 mL) was stirred at 40 C for 20 hours. The mixture was cooled to room temperature, washed with water (2 X 5 mL), brine (5 mL) dried over Na2SO4, filtered, and purified by silica gel chromatography using dichloromethane:hexanes (1:1) to afford the desired N-(2-benzoyl-phenyl)-benzenesulfonami des.

The following examples were prepared using Procedure D:

Example 22: N-(2-Benzoyl-4-chloro-phenyl)-4-ethoxy-benzenesulfonaznide ;S 0 NH O
I t Cl [000157] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 416 (M+H{).'H-NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak.at 7.24 ppm): S 1.30-1.40 (t, 3H), 8 3.85-3.95 (m, 2H), S 6.68-6.70 (d, 2H), 8 7.30-7.65 (m, 9H), 8 7.75-7.77 (d, H), 6 9.65 (s, H).

Example 23: N-(2-Benzoyl-4-chloro-phenyl)-4-propoxy-benzenesulfonamide \S 0 NH O
CI
[000158] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 430 (M+H+). 'H-NMR (Bruker 300 MHz, CDC13, shifts relative to the solvent peak at 7.24 ppm): 8 0.99-1.10 (t, 3H), 8 1.70-1.80 (m, 2H), S 3.70-3.75 (t, 2H), 8 6.68-6.70 (d, 2H), 8 7.30-7.65 (m, 9H), 8 7.75-7.77 (d, H), 8 9.65 (s, H).

Example 24: N-(2-Benzoyl-4-chloro-phenyl)-4-isopropoxy-benzenesulfonamide \ 0 NH j0JX1J1111 CI
[000159] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 430 (M+H+). 'H-NMR (CDC13, Bruker 300 MHz): 61.25-1.26 (d, 6H), 6 4.30-4.48 (m, H), 6 6.68-6.70 (d, 2H), 6 7.30-7.65 (m, 9H), 6 7.75-7.77 (d, H), S 9.70 (s, H).

Example 25: N-(2-Benzoyl-4-chloro-phenyl)-4-butoxy-benzenesulfonamide NH O
1 / .
O \ \
ci [000160] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 444 (M+1). 'H-NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm): S 0.95-1.00 (t, 3H), -S 1.40-1.60 (m, 2H), S 1.70-1.80 (rn, 2H), 6 3.75-3.80 (t, 2H), 6 6.68-6.70 (d, 2H), S 7.30-7.65 (m, 9H), b 7.75-7.77 (d, H), S 9.70 (s, H).

Example 26: N-(2-Benzoyl-4-chloro-phenyl)-4-benzyloxy-benzenesulfonamide \ o NH p CI

[000161] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 478 (M+H+). 'H-NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm): S 4.93 (s, 2H), 56.75-6.80 (d, 2H), S 7.335-7.55 (m, I1H), S 7.60-7.70 (m, 3H), 8 7.78-7.80 (d, H), S 9.70 (s, H).

Example 27: N-(2-Benzoyl-4-chloro-phenyl)-4-phenoxy-benzenesulfonamide O
I I

p I ~ I

[000162] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 464 (M+1{). 1H-NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm): 8 (ppm) = 6.78-6.80 (d, 2H), 6.90-6.93 (d, 2H), 7.20-7.24 (t, H), 7.33-7.45 (m, 3H), 7.45-7.53 (m, 5H), 7.60-7.70 (m, 3H), 7.75-7.77 (d, H), 9.78 (s, H).

III. General Synthesis of 2-Amino-Pyridophenone-Sulfonamides A N Procedure E A [JN N
+ x4l j I

Procedure F B I A N
o a Procedure G
orH
B

Scheme III: General Synthesis of 2-Amino-Pyridophenone-Sulfonamides Procedure E: (BOC protection of substituted 2-aminopyridines) [000163] To a mixture of 2-amino-5-substituted-pyridine (0.10 mol), 4-dimethylaminopyri dine (DMAP, 1.22 g, 0.01 mol), and triethylamine (TEA, 20 mL, 0.15 mol) in dichloromethane (80 mL) and DMF (4 mL) at 0 C wass added a solution of di-t-butyl dicarbonate (28.4 g, 0.13 mol) in dichloromethane (20 mL). The mixture was stirred at room temperature overnight. The mixture was washed with water (3 x 100 mL), brine (100 mL), dried with anhydrous Na2SO4, and filtered. The filtrate was concentrated in vacuo to afford a solid which was collected by filtration and washed with small amount of DCM to give the expected product in 40-60% yield.

The following example was prepared using Procedure E:

Example 28: (5-Chloro-pyridin-2-yl)-carbamic acid tert-butyl ester [000164] 1H-NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm)1.54 (s, 9H), 7.59-7.64 (dd, H), 7.94-7.97 (d, H), 8.24-8.25 (dd, H), 8.39 (b, M. LC-MS
showed the product to be > 95% pure. The molecular ion was not observed but the fragment corresponding to loss of the t-butyl group was evident (M.W. of 173 / 175).

Procedure F: (Synthesis 2-aminopyridin 3- phenyl-methanones or 2-aminopyridin-3-yl)-pyridin-4-yl-methanones) [000165] A solution of BOC protected 5-substituted 2-aminopyridine (10 mmol) in anhydrous tetrahydrofuran (THF, 5 mL) was cooled to -78 C under nitrogen atmosphere with stirring. A solution of n-butyl lithium in hexane (2.5 M, 8.8 mL) was added dropwise, and the mixture was stirred at 00 C for 10 min. A Weinreb amide (12 mmol) was prepared as in Procedure A and was dissolved in anhydrous THE (5 mL) and added to the reaction mixture.
The reaction mixture was warmed to room temperature and stirred for 2 hours.
The reaction was added to an ice-0.18 M aqueous citric acid solution (1008 - 130 mL) mixture, then extracted with ethyl acetate (EtOAc, 150 mL and 50 mL). The combined organic layer was washed with water (2 x 100 mL), brine (100 mL), dried over anhydrous Na2SO4, and filtered.
The crude material concentrated from the filtrate was purified by flash chromatography to give a solid product. This compound was heated in 4 N HCI/dioxane (6 mL) at 100 C for 2 hours, then cooled to room temperature. The mixture was evaporated in vacuo and the residue was taken up into a saturated aqueous NaHCO3 solution (50 mL) and extracted with EtOAc (2 x 50 mL). The combined organic layer was washed with water (2 x 50 mL), then with brine (50 mL), dried over anhydrous Na2SO4, and filtered. The filtrate was evaporated and dried in vacuum to afford a pale yellow solid product in yields of 40-60%
for the two steps.

The following examples were prepared using Procedure F:

Example 29: (2-Amino-5-chloro-pyridin-3-yl)-pyridin-4-yI-methanone [000166] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 234 (M+W). 'H-NMR (Bruker 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 8 6.96 (b, 2H), 8 7.40-7.44 (m, 2H), 8 7.62-7.63 (d, H), 8 8.25-8.26 (d, H), S 8.81-8.84 (m, 2H).

Example 30: (2-Amino-5-chloro-pyridin-3-yl)-phenyl-methanone:

[000167] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 233 (M+H}). 'H-NMR (Broker 300 MHz, CDC13, shifts relative to the solvent peak at 7.24 ppm): 8 6.69-6.84 (br s, 2H), 7.48-7.54 (m, 211), 7.57-7.65 (m, 3H), 7.74-7.75 (d, H), 8.22-8.23 (d, H).

Procedure G: (Alternate synthesis of sulfonamides using NaH) [000168] To a solution of a 2-aminopyridophenone (0.5 mmol) in dry DMF (1 mL) at 0 C was added NaH (60%, 20 mg, 0.5 mmol). The mixture was stirred for 5 min.
The a sulfonyl chloride (0.55 mmol) in dry DMF (1 mL) was added, and the mixture stirred at 0 C
for 10 min. The second portion of NaH (0.25 mmol) was added, and the mixture stirred at room temperature for 2 hours. The mixture was quenched with ice water (20 mL) and extracted with EtOAc (3 x 10 mL). The combined organic layers were washed with water (2 x 10 mL), brine (10 mL), dried over anhydrous Na2SO4, filtered, and evaporated in vacuo to give crude product. The crude product was purified by chromatography using DCM:EtOAc (100:0 to 98:2) or hexane:EtOAc (9:1) as eluent to afford the purified product in 10-24%
yield.

The following examples were prepared using Procedure G:

Example 31: N-(3-Benzoyl-5-chloro-pyridin-2-yl)-4-isopropoxy-benzenesulfonamide o )j(NHO

O N+
I

C!
[0001691 LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 431 (M+H{)'H-NMR (Broker 300 MHz , CDCl3, shifts relative to the solvent peak at 7.24 ppm): S 1.34-1.36 (d, 6H), S 4.57-4.70 (m, H), 8 6.91-6.98 (d, 2H), S 7.50-7.70 (m, 5H), S 7.82-7.83 (d, H), 8 8.08-8.12 (d, 2H), 6 8.38-8.39 (d, H), 8 10.70 (s, H).
Elemental analysis: C = 58.26% / cal. 58.53%, H = 4.65% / cal. 4.44%, N = 6.26% / cal.
6.50%.
Example 32: N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyll-4-ethoxy-benzenesulfonamide o N

[0001701 LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 417 (M+H+); 1H NMR (CDCI3, shifts relative to the solvent peak at 7.24 ppm) S 9.90 (1H, s), S 8.80 (2H, s), 8 7.79 (1H, d), 8 6.76 (2H,d), 8 7.51 (1H, d), S 7.33-7.20 (3H, m), 6 6.75 (2H, d), 8 3.90 (2H, m), 8 1.5 (3H, m).

Example 33: N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isopropyl-benzenesulfonarnide \s 0 NH O

I / I N
CI
[000171] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 415 (M+ H}); 'H NMR (Broker 300 MHz, CDC13, shifts relative to the solvent peak at 7.24 ppm) S 10.06 (114, s), 8 8.77 (1H, s), 6 7.79 (1H, d), S 7.70-7.62 (3H,m), S
7.56-7.51 (1H, m), 8 7.33-7.16 (5H, m), S 1.19 (6H, m), 8 2.88 (1H, m).

Example 34: N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isobutyl-benzenesulfonamide N
CI
[000172] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 429 (M+ 11);1H NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm) 810.06 (1H, s), S 7.77 (114, s), 8 7.67-7.61 (3H, m), 6 7.58-7.47 (1H, m), S 7.33-7.24 (3H, m), 6 7.17-7.08 (3H, m), S 2.42 (2H, m), 8 0.86 (6H, m).

[000173] Another example of a compound prepared using Procedure G is N-[4-chloro-2-(pyridine-4-carbonyl)-phenyl]-4-ethyl-benzenesulfonamide. LC-MS showed the product to be > 95% pure and to have the expected M.W. of 401 (M+ H+).

Procedure H: (Alternate synthesis of sulfonamides using Na(TMS)2M

[000174] To a suspension of a 2-aminopyridophenone (1 mmol) in dry DMF (5 mL) at 0 C was added a solution of sodium bis(trimethylsilyl)amide in THE (1M, 2.2 mL). This mixture was stirred at 0 C for 20 min. A solution of a sulfonyl chloride (1.3 mmol) in dry DMF (2 mL) was added, and the reaction mixture was stirred at room temperature overnight.
The reaction was quenched with ice water (60 mL), neutralized with 0.18 M
aqueous citric acid solution (3 mL) to about pH 7.5, then extracted with EtOAc (60 mL, 2 x 20 mL). The combined organic layers were washed with water (2 x 50 mL), brine (50 mL), dried over anhydrous Na2SO4, filtered, and evaporated in vacua to give a crude product.
The crude product was purified by chromatography using DCM:EtOAc (6:4) as elute to afford a solid product in 20-25 % yield.

The following examples were prepared using Procedure H:

Example 35: N-[5-Chloro-3-(pyridine-4-carbonyl)-pyridin-2-yl]-4-ethoxy-benzenesulfonamide NH O
N I
N
CI
[000175] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 418 (M+H+). 1H-NMR (Broker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm): S 1.40-1.44 (t, 3H), 54.03-4.12 (m, 2H), 8 6.93-6.96 (d, 2H), 5 7.39-7.42 (d, 211), 5 7.70-7.72 (d, H), 5 8.08-8.11 (d, 2H), S 8.39-8.40 (d, H), 8 8.84-8.86 (d, 2H), 8 10.73 (s, IT).

Example 36: N-[5-Chloro-3-(pyridine-4-carbonyl)-pyridin-2-yl]-4-isopropoxy--benzenesulfonamide O
O N
N
I

CI
[000176) LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 432 (M+H+). 1H NMR (Bruker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm): S 1.35-1.36 (d, 6H), 6 4.57-4.67 (m, H), 6 6.92-6.95 (d, 2H), S 7.42-7.44 (d, 214), S 7.72-7.73 (d, H), b 8.08-8.11 (d, 21-1), 6 8.41-8.42 (d, H), S 8.84-8.87 (d, 2H), S 10.74 (s, H).

IV. Synthesis of (2-Amino-5-Chloro-Phenyl)-Pyridin-3-yl-Methanones 1 A + CIB ProcedureI B I A
NN
CI CI

Scheme IV: Synthesis of (2-amino-5-chloro-phenyl)-pyridin-3-yl-methanones.

Procedure I: (Alternate synthesis of (2-amino-5-choro-phenyl)-pyridin-3-yl-methanones using BC13) [000177] To a solution of 85 mL BC13 in 80 mL 1,1,2,2-tetrachloroethane, stirred in an ice bath, was added a solution of 4g of p-chloroaniline in 50 mL of tetrachloroethane. After 5 min, 3g of 3-cyanopyridine is added followed by 7g of aluminum chloride. The mixture was stirred at room temperature for 20 min and then heated at reflex for 6 hr.
After cooling, 25 mL of 3N HCl was added and refluxing continued for 1 hr. After cooling, the filtrate was concentrated, made basic with 6N NaOH, then extraction with dichloromethane.
The organic solution was dried over MgSO4 and concentrated. The residue was flash chromatographed on silica gel (Hexane/EtOAc = 2:1) to give a 10-20% yield of product.

The following Example was prepared using Procedure 1:

Example 37: (2-Amino-5-chloro-phenyl)-pyridin-3-yl-methanone N
CI
[000178] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 233. (M+H}). 'H NMR (Broker 300 MHz , CDC13, shifts relative to the solvent peak at 7.24 ppm) S 8.95(s, IM, S 8.80 (d, 11-1), S 8.18 (d, 1H), S 7.40-7.45 (m, 1H), S 7.20-7.30 (m, 2H) S 7.10 (s, IH), S 6.30 (br s, 2H).

[000179] (2-Amino-5-choro-phenyl)-pyridin-3-yl-methanones prepared using the method depicted in Scheme III can be converted to the corresponding aryl sulfonamide or heteroaryl sulfonamide using Procedure G or H. The following example was prepared using the method depicted in Scheme III followed by Procedure G or H:

[000180] Example 38: N-[4-Chloro-2-(pyridine-3-carbonyl)-phenyl]-4-methyl-benzenesulfonamide NH

CI
[000181] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 387 (M+ 1-1); 'H NMR (Broker 300 MHz , CDCl3, shifts relative to the solvent peak at 7.24 ppm) 8 9.66 (s, 1H), S 7.87-7.76 (m, 3H), 5 7.56-750 (m, 4H), S 7.43-7.40 (m, 111), 5 7.28 (s, 1H), 8 7.08 (d, 2H), 8 3.50 (s, 3H).

V. Synthesis of (2-amino-5-chloro-phenyl)-pyridin-4-yl-methanones Procedure] H
A I A + B Procedure K
r N

CI CI

O O

B I A Procedure L I B I A

N N
cl Ct O

O HN
Procedure M B I A
N / /

CI

Scheme V: Synthesis of (2-amino-5-chloro-phenyl)-pyridin-4-yl-methanones Procedure J: (Pivaloyl protection of 4-chloro aniline) [000182] To a mixture of 2.3 g of 4-chloroaniline and 3 mL of triethylamine in 20 mL of dichloromethane,was added 2.3 g of trimethylacetyl chloride. The reaction mixture was stirred overnight at room temperature, then washed with 1 N HCI. The organic layer was separated and dried over MgSO4. Removal of the solvent afforded 4.5 g of pure product.

The following examples were prepared using Procedure J:

Example 39: N-(5-Chloro-pyridin-2-yl)-2,2-dimethyl-propionamide O NH

N
CI
[000183] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 213 (M+W).

Example 40: N-(4-Chloro-phenyl)-2,2-dimethyl-propionamide HN
CI
[000184) LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 212. (M+Ht). 1H NMR (Bruker 300 MHz , CDCI3,'shifts relative to the solvent peak at 7.24 ppm) 510.51 (s, 1H), S 7.25 (d, 2H), 57.15 (d, 2H), 81.51 (s, 9H).

Procedure K:

[000185] A solution of 2 g of pivaloyl protected 4-chloroaniline in 50 mL of THE was cooled to -78'C under nitrogen. A solution of n-butyl lithium (14 mL of 2 N in hexane) was added dropwise. The mixture was allowed to warm 0 C and stirring continued at 00 C for one hour. A pyridine 4-carboxaldehyde was added to the solution and the reaction was stirred at 00 C for one hour. The reaction mixture was poured into ethyl acetate and washed with water. The organic layer was separated and dried over MgSO4. Removal of the solvent followed by chromatography on silica gel (hexane:ethyl acetate 2:1 as eluent) afforded 1 g of the desired product.

The following example was prepared using Procedure K:

Example 41: N-[4-Chloro-2-(hydroxy-pyridin-4-yl-methyl)-phenyl]-2,2-dimethyl-propionamide N
O r I
NH

OH
CI
[000186] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 319. (M+H+).

Procedure L:

[0001871 The alcohol from Procedure K (1 g) was dissolved in 25 mL of dichloromethane. Manganese dioxide (2 g) was added and the mixture was heated to reflux for 2 hours. After cooling and filtration, the solvent was evaporated to give 0.95 g of the desired ketone.

The following example was prepared using Procedure L:

Example 42: N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-2,2-dimethyl-propionamide N
O

NH
, ' O
CI
[000188] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 317 (M+H+). 1H NMR (Broker 300 MHz, CDC13, shifts relative to the solvent peak at 7.24 ppm) 510.06 (s, 1H), 6 8.87 (d, 2H), 6 8.8 (d, 1H), 6 7.61(d, 1H), 6 7.50 (d, 2H), 6 7.47 (s, 1H), 6 1.35 (s, 9H).

Procedure M:

[000189] A solution of the pivaloyl protected (2-amino-5-chloro-phenyl)-pyridin-4-yl-methanone from Procedure L (2 g) was dissolved in 25 mL of ethanol along with 8 mL of 6 N
HCl. The mixture was brought to reflux for 7 hours. The ethanol was removed by rotary evaporation and the solution neutralized with 6 N NaOH. The precipitated solid was collected by filtration, washed with water, and dried to yield (2-amino-5-chloro-phenyl)-pyridin-4-yl-methanone.

The following example was prepared using Procedure M:

Example 43: (2-Amino-5-chloro-phenyl)-pyridin-4-yl-methanone [000190] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 233. (M+W). 1H NMR (Broker 300 MHz , CDC13, shifts relative to the solvent peak at 724 ppm) S 8.80 (d, 2H), S 7.45 (d, 2H), 8 7.29 (m, 2H), S 6.70 (d, 1H), S
6.33 (br s, 2H).
[000191] (2-Amino-5-chloro-phenyl)-pyridin-4-yl-methanones prepared using the method depicted in Scheme IV-can be converted to the corresponding aryl sulfonamide or heteroaryl sulfonamide using Procedure G or H. The following example was prepared using the procedure depicted in Scheme IV followed by Procedure G or H:

Example 44: N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-ethyl-benzenesulfonamide N

K HN/ \0 CI

[000192] LC-MS showed the product to be > 95% pure and to have the expected M.W.
of 401 (M+ H+);1H NMR (Broker 300 MHz, CDC13, shifts relative to the solvent peak at 7.24 ppm) 8 10.0 (s, 1H), 8 7.78 (d, 1H), 8 7.64-7.58 (m, 3H), 8 7.52 (d, 1H) 8 7.34-7.21 (m, 3H), 8 7.17-7.21 (m, 3H), 6 2.58 (m, 2H), 8 1.15 (m, 3H).

VI. Synthesis of Sulfones and Sulfoxides SH F Procedure N \ Procedure O
CI CI

S HN
" Procedure C
+ CI'O i j R
CI
CI
Procedure P Procedure 0 R

CI CI

Procedure N: Production of 4-Chloro-l-nitro-2-phenylsulfanyl-benzene [000193] To a solution of 2 g of 2-fluoro-4-chloro-nitrobenzene in 50m1 DMF
and 1.25 ml of thiophenol was added 1.9 nil triethylamine at room temperature. The mixture was stirred for one hour. One hundred mL of water was added and a yellow solid crashed out of solution. The solid was collected by filtration and dried. Yield: 50-70%. LC-MS showed a single peak with the expected (M+H+) of 267.

Procedure 0: Production of 4-Chloro-2-phenylsulfanyl-phenylamine [000194] To a suspension of 1.8g of 2- benzylthio-4-chloro-nitrobenzene in IOOm"
ethanol was added 2g powdered iron and 20 mL of 0.33N NH4CI. The mixture was heated at 70 C for 6 hr. The mixture was cooled and filtered through a pad of Celite.
The filtrate was condensed and purified by flash chromatography (hexane/ethyl acetate 4:1 as eluent) to yield 1.25g of an oil. LC-MS showed a single peak with the expected (M+W) of 236.

The following example was prepared by Procedure C:

Example 116: (4-Chloro-2-phenylsulfanyl-phenyl)-4-isopropoxy-benzenesulfonamide Y
o \\
HNC \\
O

as [000195] The product showed a single peal: by LC-MS with the expected (M+H+) of 434.
Procedure P:

[000196] To a solution of the 0.5 g of the sulfide from procedure C in 20m1 DCM, was added one equivalent of m-chloro peroxybenzoic acid (mCPBA). The mixture was stirred at room temperature overnight. The mixture was concentrated and purified by flash chromatography (hexane / ethyl acetate =2:1 as eluent) to give 0. 12g of white solid as product.

The following example was prepared using Procedure P:

Example 63: N-(2-Benzenesulfinyl-4-chloro-phenyl)-4-isopropoxy-benzenesulfonamide = / o S
O I

CI
[000197] LC-MS showed a single peak with the expected (M+H}) 450.
Procedure Q:

[000198] To a solution of the 0.5 sulfide from procedure C in 20m1 DCM, added two equivalents of mCPBA. The mixture was stirred at room temperature overnight.
The mixture is concentrated and purified by flash chromatography (hexane / ethyl acetate =2:1 as eluent) to give 0.148 of white solid as product.

The following example was prepared using Procedure Q.

Example 117: N-(2-Benzenesulfonyl-4-chloro-phenyl)-4-isopropoxy-benzenesulfonamide Y
o p HN 0 CI
[000199] LC-MS showed a single peak with the expected (M+H}) 466.
The following example was prepared using Procedure G:

Example 118: N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonanude N

HN/
O

CI
[000200] LC-MS showed a single peak with the expected (M+H}) of 431.
00 /o q O HN~s O HN
mCPBA
O
CH C OA, CI CI
Procedure R

Procedure R:

[000201] N-[4-Chloro-2-(pyridine-4-carbonyl)-phenyl]-4-isopropoxy-benzensulfonamide (60 mg) was dissolved in 5mL of dichloromethane. 1.05eq. of mCPBA
was added and the mixture stirred at room temperature overnight . The solvent was removed by rotary evaporation and the residue chromatographed on silica gel (hexane /ethyl acetate =
1:1 as eluent ) to give the product. Yield: 95%.

The following example was prepared using Procedure R:

Example 119: N-[4-Chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-4-isopropoxy-benzenesulfonamide O HN/

Ci 119.

[000202] LC-MS showed a single peak with the expected (M+H4) of 447.

[000203] Other examples listed herein can be made by the general procedures outlined above.

BIOLOGICAL DATA

1. FMAT Assay: FMAT Assay determine inhibitors of TECK binding to human CCR9 receptors:

[000204] A CCR9 assay buffer was prepared by adding 5mL of 1M HEPES, 1.25 mL
of 1M CaC12,1.5 mL of 1M MgC12,14 mL of 5M NaCl, 0.5g fatty acid free bovine serum albumin, and 1 mL of 5% azide were added to 400 mL of distilled, deionized water (ddH2O).
The solution was mixed until all the fatty acid free bovine serum albumin was dissolved.
After pH was adjusted to 7.4, the final volume was adjusted to 500 mL, and the solution was filtered through a 0.2 m filter.

[000205] A 1000 nM biotinylated human TECK in assay buffer was prepared. A 14 tM
solution of Cy5-a-Biotin working solution was prepared. Biotinylated TECK and Cy5-a-Biotin working solutions were mixed right before cells were ready to be added into wells. 13 mL of assay buffer was added to a 50 mL polyethylene tube. 5.6 tL of 1000 nM
biotinylated TECK working solution and 178 L of 14 g/mL Cy5-a-Biotin working solution were added to the tube and mixed. The final biotinylated TECK concentration was 0.4 nM
and the final Cy5-a-Biotin concentration 0.064 g/ML.

[000206] Cells were plated right before all other reagents are added to wells.
Cells were collected and centrifuged in a tabletop centrifuge at 1200 rpm for 5 minutes.
The supernatant was removed by vacuum without disturbing cell pellet. The cells were resuspended in 5 mL
of assay buffer. The cells were counted by adding 1 mL of a cell suspension to an eppendorf tube. Then 150 tL of this suspension was added to 150 L of Trypan Blue. Then 10 pL of Trypan Blue suspension was added to hemocytometer, and the cell number per mL
was calculated. The cells were resuspended with CCR9 assay buffer to final 0.2 x 106 cells/mL
for the assay. Approximately 2.6 x 106 cells for 1 384 well plate was needed.

[000207] 20 p.L of a test compound dissolved in DMSO was added to a well a polypropylene 384 well plate. Multiple compounds were tested simultaneously by adding a different test compound to each well. A control of 20 tL of DMSO in assay buffer was prepared.. 20 L of the Biotin-Teck and Cy5-a-Biotin mixed solution was added to each well of the polypropylene plate. 20 L of cells suspension at 0.2 x 106/mL was added to each well. The assay plate was incubated on a rotator at room temperature for 1.5 hour. FMAT
was read (PMT= 490/518 or 537/568, threshold set a t 1 standard deviation).

H. FLIPR Assay: FLIPR Assay determines inhibitors of TECK induced response in Chinese Hamster Ovary (CHO) cells that over express recombinant human CCR9 and the Gal6 protein.

[000208] The day before the assay was run, CHO, cells were diluted to give appropriately 10,000 cells/well.(in a volume of 50 mL). Each well of the 384 black/clear.
plate was then seeded with 50 mL of the diluted cell suspension. The cell plates were placed in a 37 C tissue culture incubator at 6% CO2 overnight.

[000209] A wash buffer and a dye loading solution were prepared on the day the assay was preformed. The wash buffer was prepared by mixing 880 mL of Nanopure water, 100 ml- of lOx HBSS and 20 mL of IM HEPES to give 1 L of a Ix HESS and 20mM HEPES
solution. 1g of BSA (bovine serum albumin) was added to the lx HBSS/20 mM
HEPES
solution. A 250 mM probenecid stock solution was prepared by dissolving 710 mg of probenecid in 5 mL of I N NaOH and 5 mL of previously prepared Ix HBSS/20 mM
HEPES/0.1% BSA buffer. 10 mL of 250 mM probenecid was added to thelx HBSS/20 mM
HEPES/O.l% BSA buffer to give a wash buffer having lx HBSS/20 mM HEPES/2.5 mM
probenecid/0.1% BSA.

8-t [000210] For each 384 well plate, I1 mL of 2x FLUO-3 dye loading solution was required. The 2x FLUO-3 dye loading solution prepared by adding 22 mL of DMSO
(100%) to each of 2 x 50 mg vials of FLUO-3. The vials were vortexed, then 22 mL of 20% pluronic acid was added to each 50 mg vial of FLUO-3 and vortex. 88 mL of reconstituted stock solution was added to 11 mL of Ix wash buffer.

[000211] Each cell plate was washed with the wash buffer. At the end of the wash, there was 25 mL residual volume per well. 25 mL of dye loading solution was added to each well of the 384 plate. The plates were placed in an incubator for at least 1 hour. A
yellowplate calibration plate was run on a FLIPR 384, and a standard deviation of less than 3.5 % was obtained.

[000212] 10 mM stock concentrations of compounds in 100% DMSO were prepared and stored at room temperature. Stock concentrations (100x final assay concentration) 9x 1:3 serial dilutions in 100% DMSO were prepared in order to carry out 10 point concentration response curves. 3x final assay concentration were prepared by making 1 in 33.3 dilutions of the 100x stocks in wash buffer and were plated into Greiner 384 well plates.
10 point concentration response curves started at 100 mM, 10mM or 1mM (final assay concentration).
The 1st compound was added to wells Al - AlO and other compounds were added down the plate to P1- PIO. Columns 11 and 12 were control wells, with FLPR buffer (with 3%
DMSO) added to wells Al 1-H12. The remaining compounds were added to A13 - A22 down through P13 - P22. Each compound was tested in triplicate.

[000213] Ligand (rhTECK) plate at 4x ligand EC50 (final assay concentration) in wash buffer was prepared and plated into a Greiner 384 well plate. Appropriate amount of 4x ligand was added to wells Al through P1O and A13 through P22. In columns 11 and 12, FLIPR wash buffer was added to wells All -D12 and 4x ligand solution was added to wells Ell - H12.

[000214] The cell plates were incubated at least a 1 hour with the dye solution, then washed with wash buffer. At the end of the wash, there was 25 mL residual volume per well.
The cell plate were loaded onto the stacker of FLIPR-384. Individual well activity (1WA) was measured, using the max-min function between timepoints 88-145. Data was expressed as % inhibition of rhTECK induced response, and IC50 values were calculated for compounds displaying antagonist activity.

[000215] Inhibition of binding of human TECK to human CCR9 receptors (FMAT
assay) and inhibition of human TECK induced response(FLIPR) [000216] Of the compounds tested in the FMAT assay described above, the following provided an IC50 value less than or equal to about 1.0 M: 17-21, 31-34,44, 70, 73, 74, and 115.

[000217] Of the compounds tested in the FLIPR assay described above, the following provided an IC50 value less than or equal to about 1.0 gM: 8-13, 14-15, 17-20, 22-24, 31-36, 44, 49, 63, and 69-89, 116-143.

Claims (57)

1. A compound having the following structural formula:
or a pharmaceutically acceptable salt thereof, wherein:
Y is C=O;
R8 is halo, nitro, alkylcarbonyl, or trihaloalkyl;
m and n are each, independently, 0 or an integer from 1 to 3;
each R9 is, independently, aliphatic, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, hydroxy, NR11CO2R12, C(O)N(R11)2, C(O)R12, CO2R12, OC(O)N(R11)2, OC(O)R12, N(R11)2, or NR11C(O)R12; or two adjacent R9 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1, or 2 heteroatoms selected from N, O, and S;
wherein each R11 is, independently, selected from H or an aliphatic group; and is an aliphatic group; and each R10 is, independently, halo, aliphatic group, alkoxy, or haloalkyl.
2. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
3. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
4. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
5. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
6. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
7. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
8. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
9. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
10. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
11. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
12. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
13. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
14. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
15. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
16. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
17. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
18. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
19. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
20. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
21. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
22. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
23. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
24. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
25. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
26. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
27. A compound having the formula:

or a pharmaceutically acceptable salt thereof.
28. A pharmaceutical composition comprising a compound having the following structural formula:

or a pharmaceutically acceptable salt thereof, wherein:
Y is C=O, S(O), or S(O)2;
R8 is halo, nitro, alkylcarbonyl, or trihaloalkyl;
Ar1 is substituted or unsubstituted phenyl; and Ar2 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, and a pharmaceutically acceptable carrier.
29. The pharmaceutical composition of claim 28, wherein Ar1 is optionally substituted phenyl, Ar-2 is optionally substituted phenyl or thienyl, Y is C=O, and R8 is halo.
30. The pharmaceutical composition of claim 29, wherein R8 is chloro.
31. The pharmaceutical composition of claim 28, wherein the compound is represented by the following structural formula:

wherein:
Y is C=O;
R8 is halo, nitro, alkylcarbonyl, or trihaloalkyl;
m and n are each, independently, 0 or an integer from 1 to 3;
each R9 is, independently, aliphatic, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, hydroxy, NR11CO2R12, C(O)N(R11)2, C(O)R12, CO2R12, OC(O)N(R11)2, OC(O)R12, N(R11)2, or NR11C(O)R12; or two adjacent R9 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1, or 2 heteroatoms selected from N, O, and S;
wherein each R11 is, independently, selected from H or an aliphatic group; and is an aliphatic group; and each R10 is, independently, halo, aliphatic group, alkoxy, or haloalkyl; or two adjacent R10 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1 or 2 heteroatoms selected from N, O, and S.
32. A pharmaceutical composition comprising the compound of any one of claims 1 to 27, and a pharmaceutically acceptable carrier.
33. Use of the compound of any of one of claims 1 to 27 for treating an inflammatory bowel disease.
34. Use of the composition of any one of claims 28 to 32 for treating an inflammatory bowel disease.
35. Use of the compound of any of one of claims 1 to 27 in the manufacture of a medicament for treating an inflammatory bowel disease.
36. The use of any one of claims 33 to 35, wherein the inflammatory bowel disease is selected from ulcerative colitis, Crohn's disease, ileitis, Celiac disease, nontropical Sprue, enteritis, enteropathy associated with seronegative arthropathies, microscopic or collagenous colitis, eosinophilic gastroenteritis, or pouchtis resulting after proctocolectomy, and ileoanal anastomosis.
37. The use of claim 36, wherein the inflammatory disease or condition is Crohn's disease or colitis.
38. The use claim 36, wherein the inflammatory disease or condition is Celiac's disease.
39. The compound of any one of claims 1 to 27 for use in treating an inflammatory bowel disease.
40. The compound of any one of claims 1 to 27 for use in the manufacture of a medicament for treating an inflammatory bowel disease.
41. The compound of claim 39 or 40, wherein the inflammatory bowel disease is selected from ulcerative colitis, Crohn's disease, ileitis, Celiac disease, nontropical Sprue, enteritis, enteropathy associated with seronegative arthropathies, microscopic or collagenous colitis, eosinophilic gastroenteritis, or pouchtis resulting after proctocolectomy, and ileoanal anastomosis.
42. The compound of claim 41, wherein the inflammatory disease or condition is Crohn's disease or colitis.
43. The compound of claim 41, wherein the inflammatory disease or condition is Celiac's disease.
44. A commercial package comprising the compound of any one of claims 1 to 27 together with instructions for use in the treatment of an inflammatory bowel disease.
45. A commercial package comprising the pharmaceutical composition of any one of claims 28 to 32 together with instructions for use in the treatment of an inflammatory bowel disease.
46. The commercial package of claim 44 or 45, wherein the inflammatory bowel disease is selected from ulcerative colitis, Crohn's disease, ileitis, Celiac disease, nontropical Sprue, enteritis, enteropathy associated with seronegative arthropathies, microscopic or collagenous colitis, eosinophilic gastroenteritis, or pouchtis resulting after proctocolectomy, and ileoanal anastomosis.
47. The commercial package of claim 46, wherein the inflammatory disease or condition is Crohn's disease or colitis.
48. The commercial package of claim 46, wherein the inflammatory disease or condition is Celiac's disease.
49. A method of treating an inflammatory bowel disease in a subject in need thereof, comprising administering to the subject an effective amount of a compound represented by the following structural formula:

or a pharmaceutically acceptable salt thereof, wherein:
Y is C=O, S(O), or S(O)2;
X1, X2, and X3 are each independently CR;
R, for each occurrence, and R1 are each independently H, an aliphatic group, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, hydroxy, NR11CO2R12, C(O)N(R11)2, C(O)R12, CO2R12, OC(O)N(R11)2, OC(O)R12, N(R11)2, or NR11C(O)R12; wherein R11, for each occurrence is, independently, H or an aliphatic group, and R12 is an aliphatic group;
R6 is H, an aliphatic carbonyl group, or an aliphatic ester;
Ar1 is substituted or unsubstituted phenyl; and Ar2 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group.
50. The method of claim 49, wherein the compound has the following structural formula:
or a pharmaceutically acceptable salt thereof, wherein:
Y is C=O, S(O), or S(O)2;
R8 is halo, nitro, alkylcarbonyl, or trihaloalkyl;
Ar1 is substituted or unsubstituted phenyl; and Ar2 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, and a pharmaceutically acceptable carrier.
51. The method of claim 50, wherein Ar' is optionally substituted phenyl, Ar2 is optionally substituted phenyl or thienyl, Y is C=O, and R8 is halo.
52. The method of claim 51, wherein R8 is chloro.
53. The method of claim 49, wherein the compound is represented by the following structural formula:

wherein:
Y is C=O;
R8 is halo, nitro, alkylcarbonyl, or trihaloalkyl;
m and n are each, independently, 0 or an integer from 1 to 3;
each R9 is, independently, aliphatic, haloalkyl, aryl, arylalkyl, alkoxy, cycloalkoxy, haloalkoxy, aryloxy, arylalkoxy, alkylthio, halo, nitro, cyano, hydroxy, NR11CO2R12, C(O)N(R11)2, C(O)R12, CO2R12, OC(O)N(R11)2, OC(O)R12, N(R11)2, or NR11C(O)R12; or two adjacent R9 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1, or 2 heteroatoms selected from N, O, and S;
wherein each R11 is, independently, selected from H or an aliphatic group; and is an aliphatic group; and each R10 is, independently, halo, aliphatic group, alkoxy, or haloalkyl; or two adjacent R10 groups taken together with the atoms to which they are attached form a fused, saturated, unsaturated or partially unsaturated 5 to 7 membered ring having 0, 1 or 2 heteroatoms selected from N, O, and S.
54. A method of treating an inflammatory bowel disease in a subject in need thereof, comprising administering to the subject an effective amount of a compound of any one of claims 1 to 27 or a composition of any one of claims 28 to 32.
55. The method of any one of claim 49 to 54, wherein the inflammatory bowel disease is selected from ulcerative colitis, Crohn's disease, ileitis, Celiac disease, nontropical Sprue, enteritis, enteropathy associated with seronegative arthropathies, microscopic or collagenous colitis, eosinophilic gastroenteritis, or pouchtis resulting after proctocolectomy, and ileoanal anastomosis.
56. The method of claim 55, wherein the inflammatory disease or condition is Crohn's disease or colitis.
57. The method of claim 55, wherein the inflammatory disease or condition is Celiac's disease.
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Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003095967A2 (en) * 2002-05-14 2003-11-20 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with chemokine receptor 9(ccr9)
WO2003099773A1 (en) * 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US7227035B2 (en) * 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US6939885B2 (en) * 2002-11-18 2005-09-06 Chemocentryx Aryl sulfonamides
JP5008025B2 (en) 2003-02-20 2012-08-22 エンサイシブ・ファーマシューティカルズ・インコーポレイテッド Phenylenediamineurotensin-II receptor antagonist and CCR-9 antagonist
US7288538B2 (en) 2003-02-20 2007-10-30 Encysive Pharmaceuticals, Inc. Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
US7320989B2 (en) 2003-02-28 2008-01-22 Encysive Pharmaceuticals, Inc. Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists
EP1603884A4 (en) 2003-02-28 2008-05-28 Encysive Pharmaceuticals Inc Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists.
DE102004027119A1 (en) 2003-06-06 2004-12-30 Schott Ag Production of a UV-absorbed glass used in the production of gas discharge lamps, fluorescent lamps, xenon lamps, LCD displays, computer monitors and telephone displays comprises melting a raw material and producing a melt
EP1643960A2 (en) * 2003-07-02 2006-04-12 Merck & Co., Inc. Arylsulfonamide derivatives
JP2007514731A (en) * 2003-12-19 2007-06-07 ファイザー インコーポレイテッド Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-β-hsd-1) for the treatment of diabetes and obesity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7230022B2 (en) 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
US7288563B2 (en) 2004-02-19 2007-10-30 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
CA2566387A1 (en) * 2004-05-12 2005-12-01 Chemocentryx, Inc. Aryl sulfonamides as chemokine receptor ccr9 antagonists
DK1763517T3 (en) 2004-06-28 2011-06-06 Hoffmann La Roche Pyrimidine derivatives as 11beta-HSD1 inhibitors
EP1797042B1 (en) 2004-09-29 2009-01-07 F.Hoffmann-La Roche Ag Indozolone derivatives as 11b-hsd1 inhibitors
SE0402635D0 (en) * 2004-10-29 2004-10-29 Astrazeneca Ab Chemical compounds
WO2008109782A2 (en) * 2007-03-06 2008-09-12 Cedars-Sinai Medical Center Diagnosis of inflammatory bowel disease in children
EP1819827B1 (en) * 2004-12-08 2010-08-11 Cedars-Sinai Medical Center Methods for diagnosis of crohn's disease
WO2010048415A1 (en) * 2008-10-22 2010-04-29 Cedars-Sinai Medical Center Methods of using jak3 genetic variants to diagnose and predict crohn's disease
WO2008101133A2 (en) * 2007-02-14 2008-08-21 Cedars-Sinai Medical Center Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease
US7622583B2 (en) 2005-01-14 2009-11-24 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
AU2006204750C1 (en) * 2005-01-14 2012-11-01 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
KR20080016649A (en) * 2005-06-16 2008-02-21 화이자 인코포레이티드 N-(pyridin-2-yl)-sulfonamide derivatives
FI20055498A0 (en) * 2005-09-16 2005-09-16 Biotie Therapies Corp Sulfonamides
GB0524786D0 (en) * 2005-12-05 2006-01-11 Glaxo Group Ltd Compounds
GB0526255D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0526252D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0526445D0 (en) * 2005-12-23 2006-02-08 Novartis Ag Organic compounds
US8519135B2 (en) 2006-07-14 2013-08-27 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2/CCR9
ATE498615T1 (en) 2006-07-14 2011-03-15 Chemocentryx Inc TRIAZOLYLPHENYLBENZENESULFONAMIDES
WO2008008374A2 (en) * 2006-07-14 2008-01-17 Chemocentryx, Inc. Ccr2 inhibitors and methods of use thereof
HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
TW200829578A (en) 2006-11-23 2008-07-16 Astrazeneca Ab Chemical compounds 537
JO2754B1 (en) 2006-12-21 2014-03-15 استرازينكا ايه بي Indazolyl amide derivatives for the treatment of glucocorticoid receptor mediated disorders
CA2677096A1 (en) 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated Kinase inhibitors
WO2008106451A2 (en) * 2007-02-26 2008-09-04 Cedars-Sinai Medical Center Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
WO2010039931A2 (en) * 2008-10-01 2010-04-08 Cedars-Sinai Medical Center Methods of using il17rd and il23-il17 pathway genes to diagnose crohn's disease
WO2008137762A2 (en) * 2007-05-04 2008-11-13 Cedars-Sinai Medical Center Methods of diagnosis and treatment of crohn's disease
US8486640B2 (en) 2007-03-21 2013-07-16 Cedars-Sinai Medical Center Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease
US20100184050A1 (en) * 2007-04-26 2010-07-22 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease in the puerto rican population
US7776877B2 (en) 2007-06-22 2010-08-17 Chemocentryx, Inc. N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides
JP5306344B2 (en) 2007-07-12 2013-10-02 ケモセントリックス, インコーポレイテッド Fused heteroarylpyridyl and phenylbenzenesulfonamides as CCR2 modulators for the treatment of inflammation
US20090028866A1 (en) * 2007-07-27 2009-01-29 John Wayne Cancer Institute USE OF CCR9, CCL25/TECK, AND NITEGRIN alpha4 IN DIAGNOSIS AND TREATMENT OF MELANOMA METASTASIS IN THE SMALL INTESTINE
US8211930B2 (en) 2008-05-20 2012-07-03 Astrazeneca Ab Phenyl and benzodioxinyl substituted indazoles derivatives
US8569337B2 (en) 2008-07-23 2013-10-29 Vertex Pharmaceuticals Incorporated Tri-cyclic pyrazolopyridine kinase inhibitors
CN102131809A (en) 2008-07-23 2011-07-20 沃泰克斯药物股份有限公司 Tri-cyclic pyrazolopyridine kinase inhibitors
CA2731451A1 (en) 2008-07-23 2010-01-28 Vertex Pharmaceuticals Incorporated Pyrazolopyridine kinase inhibitors
CN102159546A (en) 2008-08-06 2011-08-17 沃泰克斯药物股份有限公司 Aminopyridine kinase inhibitors
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
US9580752B2 (en) 2008-12-24 2017-02-28 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (MR-UC) requiring colectomy
EP2427464A1 (en) 2009-05-06 2012-03-14 Vertex Pharmaceuticals Incorporated Pyrazolopyridines
ES2547072T3 (en) * 2009-07-21 2015-10-01 The Board Of Trustees Of The Leland Stanford Junior University Heteroaryl benzamides, compositions and methods of use
WO2011017120A1 (en) * 2009-07-27 2011-02-10 Cedars-Sinai Medical Center Use of ccr9, ccl25, batf and il17/il23 pathway variants to diagnose and treat inflammatory bowel disease
CA2787079A1 (en) 2010-01-27 2011-08-04 Vertex Pharmaceuticals Incorporated Pyrazolopyrazine kinase inhibitors
EP2528917B1 (en) 2010-01-27 2016-10-19 Vertex Pharmaceuticals Incorporated Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
MX2012008643A (en) 2010-01-27 2013-02-26 Vertex Pharma Pyrazolopyrimidine kinase inhibitors.
CN108383828A (en) 2010-12-16 2018-08-10 阿勒根公司 1 new, 2- as chemokine receptor modulators is bis--sulfamide derivative
WO2012082568A1 (en) 2010-12-16 2012-06-21 Allergan, Inc. Phosphorous derivatives as chemokine receptor modulators
KR101303991B1 (en) 2011-03-18 2013-09-04 성균관대학교산학협력단 Pharmaceutical composition for preventing or treating anti-inflammatory disease or infectious disease comprising m-3M3FBS as an effective component
UA116189C2 (en) 2011-05-02 2018-02-26 Мілленніум Фармасьютікалз, Інк. FORMULATION FOR ANTI-α4β7 ANTIBODY
EP3311834A1 (en) 2011-05-02 2018-04-25 Millennium Pharmaceuticals, Inc. Formulation for anti-alpha4beta7 antibody
WO2013016156A1 (en) * 2011-07-22 2013-01-31 Glaxo Group Limited Polymorphic forms of the sodium salt of 4-tert- butyl -n-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzene sulfonamide
BR112014001530B1 (en) * 2011-07-22 2022-05-31 Chemocentryx, Inc POLYMORPHIC FORMS OF 4-TERT-BUTYLN-[4-CHLORINE-2-(1-OXY-PYRIDINE-4-CARBONYL)- PHENYL]-BENZENE SULFONAMIDE, PHARMACEUTICAL COMPOSITION AND PRODUCTION METHOD
RS56023B1 (en) * 2011-07-22 2017-09-29 Chemocentryx Inc A crystalline form of the sodium salt of 4-tert-butyl-n-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzene sulfonamide
KR102083693B1 (en) 2012-02-29 2020-03-02 케모센트릭스, 인크. Pyrazol-1-YL Benzene Sulfonamideas CCR9 Antagonists
WO2013130962A1 (en) 2012-03-01 2013-09-06 Allergan, Inc. Benzofuran- 2 - sulfonamide derivatives as chemokine receptor modulators
US9181190B2 (en) 2012-07-04 2015-11-10 Concert Pharmaceuticals, Inc. Deuterated vercirnon
AR093703A1 (en) 2012-12-04 2015-06-17 Takeda Pharmaceuticals Co PROFILACTIC OR THERAPEUTIC AGENT FOR SJOGREN SYNDROME
EP2970239B1 (en) 2013-03-12 2018-10-10 Allergan, Inc. Sulfonamide derivatives as chemokine receptor modulators
CN112870368A (en) 2013-03-27 2021-06-01 西达-赛奈医疗中心 Reduction and reversal of fibrosis and inflammation by inhibition of TL1A function and related signaling pathways
EP4105236A1 (en) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease
EP3087074A1 (en) 2013-12-23 2016-11-02 Norgine BV Benzene sulfonamides as ccr9 inhibitors
JP2017501145A (en) * 2013-12-23 2017-01-12 ノージン ビーブイ Compounds useful as CCR9 modulators
KR102642382B1 (en) 2014-10-06 2024-02-29 케모센트릭스, 인크. Combination therapy of inhibitors of c-c chemokine receptor type 9 (ccr9) and anti-alha4beta7 integrin blocking antibodies
US20170327584A1 (en) 2014-11-26 2017-11-16 Millennium Pharmaceuticals, Inc. Vedolizumab for the Treatment of Fistulizing Crohn's Disease
MA41636A (en) 2015-03-06 2018-01-09 Millennium Pharm Inc METHOD OF TREATMENT OF PRIMITIVE SCLEROSANT CHOLANGITIS
AU2017234009A1 (en) 2016-03-14 2018-09-27 Millennium Pharmaceuticals, Inc. Method of preventing graft versus host disease
BR112018068625A2 (en) 2016-03-14 2019-07-30 Millennium Pharm Inc methods of treating or preventing graft versus host disease
US11186872B2 (en) 2016-03-17 2021-11-30 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through RNASET2
IL266751B (en) 2016-11-23 2022-07-01 Chemocentryx Inc Method of treating focal segmental glomerulosclerosis
BR112019022268A2 (en) 2017-04-28 2020-05-19 Millennium Pharm Inc method for the treatment of pediatric disorders
JP2020536919A (en) 2017-10-11 2020-12-17 ケモセントリックス, インコーポレイテッド Treatment of focal segmental glomerulosclerosis with CCR2 antagonists
US10792360B1 (en) 2019-11-21 2020-10-06 Chemocentryx, Inc. Compositions and methods for treating inflammatory bowel disease using CCR9 inhibitor and anti-TNF-alpha blocking antibodies
US20210154292A1 (en) * 2019-11-21 2021-05-27 Chemocentryx, Inc. Compositions and Methods for Treating CCR9-Mediated Diseases using CCR9 Inhibitor and Anti-TNF-Alpha Blocking Antibodies

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997368A (en) * 1956-12-20 1961-08-22 Barent Mark Production of manganese hydroxide
GB884847A (en) * 1958-04-14 1961-12-20 Ciba Ltd Mercapto compounds
DE1145626B (en) * 1959-12-10 1963-03-21 Hoffmann La Roche Process for the preparation of 3H-1, 4-Benzodiazepin-2 (1H) -one derivatives
CH408940A (en) * 1959-12-10 1966-03-15 Hoffmann La Roche Process for the preparation of 1,4-benzodiazepine derivatives
US3121103A (en) * 1961-10-20 1964-02-11 Hoffmann La Roche Aminobenzophenones
US3442946A (en) * 1960-04-26 1969-05-06 Hoffmann La Roche 2-aminomercapto- and 2-aminoalkylcaptobenzophenone oximes
US3402171A (en) * 1960-12-02 1968-09-17 Hoffmann La Roche Process for preparing 5-aryl-3h-1, 4-benzodiazepin-2(1h)-ones
US3336295A (en) * 1960-12-02 1967-08-15 Hoffmann La Roche Hydroxy or alkoxy substituted 5-phenyl-3h-1, 4-benzodiazepin-2(1h)-ones
BE637329A (en) * 1962-11-13
US3534062A (en) * 1967-05-16 1970-10-13 Upjohn Co Dibenzothiadiazocines
US3551427A (en) 1969-05-09 1970-12-29 Sandoz Ag 4-thienyl-2-(1h)-quinazolones
CH561703A5 (en) 1970-12-11 1975-05-15 Hoffmann La Roche 7-Iodobenzodiazepin-2-ones - sedatives etc prepd by cyclising iodobenzophenones with glycine (esters)
GB1332697A (en) 1970-12-21 1973-10-03 Hoffmann La Roche Benzodiazepine derivatives
BE791902A (en) * 1971-11-26 1973-05-24 Wander Ag Dr A NEW DERIVATIVES OF THIENO (3,2-C) (1) BENZAZEPINE, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
US3846477A (en) * 1972-09-20 1974-11-05 Robins Co Inc A H 2-alkylamino benzophenones
CH585222A5 (en) 1973-02-14 1977-02-28 Wander Ag Dr A Prepn. of antipsychotic heterocyclic piperazine derivs. - by reaction of heterocyclic ketones with metal piperazine complexes
US4166452A (en) * 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) * 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
FR2403330A1 (en) * 1977-06-16 1979-04-13 Fabre Sa Pierre NEW DERIVATIVES OF BENZOYL-2-CHLORO-4-GLYCINANILIDES SUBSTITUTES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2449677B1 (en) 1979-02-26 1986-03-28 Fabre Sa Pierre NOVEL SUBSTITUTED BENZOYL-2 GLYCYLANILIDES DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS ANXIOLYTIC DRUGS
US4265874A (en) * 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4312996A (en) * 1980-12-29 1982-01-26 Schering Corporation Benzodiazepine intermediates
DD251126A1 (en) 1984-12-21 1987-11-04 Univ Berlin Humboldt METHOD FOR PRODUCING NEW 2-ARYLSULFONAMIDO-BENZO AND -ACETOPHENONE AND THEIR OXIMES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS
US5010195A (en) * 1988-05-25 1991-04-23 The Dow Chemical Company Herbicidal alkoxy-1,2,4-triazolo(1,5-c)primidine-2-sulfonamides
US4997940A (en) * 1986-07-11 1991-03-05 The Dow Chemical Company Pyrazolo[1,5-a]pyrimidine-2-sulfonyl chloride and -2-sulfide compounds
US4992091A (en) * 1986-07-11 1991-02-12 The Dow Chemical Company Substituted pyrazolo[1,5-a]pyrimidine-2-sulfonamides and compositions and methods of controlling undesired vegetation
US5021591A (en) * 1986-07-11 1991-06-04 The Dow Chemical Company Pyrazolo[1,5-a]pyrimidine-2-sulfide compounds
JPH01156953A (en) * 1987-09-01 1989-06-20 Hokko Chem Ind Co Ltd Benzenesulfonanilide derivative and germicide for agriculture and horticulture
JPH0753725B2 (en) * 1987-10-08 1995-06-07 富山化学工業株式会社 4H-1-benzopyran-4-one derivative and its salt, their production method and anti-inflammatory agent containing them
DE3825041A1 (en) 1988-07-20 1990-02-15 Schering Ag Pyrido[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine-2-sulphonamides, processes for their preparation, and their use as herbicides, plant growth regulators and fungicides
GB8820129D0 (en) * 1988-08-24 1988-09-28 Schering Agrochemicals Ltd Fungicides
GB8830182D0 (en) * 1988-12-23 1989-02-22 Shell Int Research Heterocyclic herbicides
US5217521A (en) * 1989-12-22 1993-06-08 Ciba-Geigy Corporation Triazolylsulfonamides
US5481005A (en) * 1990-07-31 1996-01-02 Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2679903B1 (en) 1991-08-02 1993-12-03 Elf Sanofi DERIVATIVES OF N-SULFONYL INDOLINE CARRYING AN AMIDIC FUNCTION, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.
FR2665441B1 (en) * 1990-07-31 1992-12-04 Sanofi Sa N-SULFONYL INDOLINE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME.
US5338755A (en) * 1990-07-31 1994-08-16 Elf Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
DE4025818A1 (en) * 1990-08-16 1992-02-20 Bayer Ag PHENYL SULPHONAMIDE SUBSTITUTED PYRIDINALKEN AND -AMINOOXYALKANCARBONE ACID DERIVATIVES
US5185348A (en) * 1990-08-16 1993-02-09 Bayer Aktiengesellschaft Phenylsulphonamide substituted pyridinealkene- and -aminooxyalkanecarboxylic acid derivatives
JPH04248984A (en) * 1991-02-05 1992-09-04 Kuraray Co Ltd Superoxide dismutase derivative and production thereof
IE920175A1 (en) * 1991-02-11 1992-08-12 Zeneca Ltd Nitrogen heterocycles
IL101860A0 (en) * 1991-05-31 1992-12-30 Ici Plc Heterocyclic derivatives
RU2086544C1 (en) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity
JPH06135934A (en) * 1991-12-27 1994-05-17 Ishihara Sangyo Kaisha Ltd Phospholipase a2 inhibitor, anti-inflammatory agent of anti-pancreatitic agent containing pyridine derivative or its salt
JPH06145145A (en) 1991-12-27 1994-05-24 Ishihara Sangyo Kaisha Ltd Aminotrifluoromethylpyridine derivative or its salt, production thereof and phospholipase a2 inhibitor, antiinflammatory agent and antipancreatitic agent comprising the same
EP0556673B1 (en) 1992-02-15 1997-09-17 Hoechst Aktiengesellschaft Ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as medicaments containing them
JP3229668B2 (en) 1992-09-25 2001-11-19 株式会社リコー Telelighting device
TW287160B (en) * 1992-12-10 1996-10-01 Hoffmann La Roche
NZ250916A (en) 1993-02-27 1995-08-28 Nihon Nohyaku Co Ltd N-heteroaryl-n'-phenylureas, their use as acat inhibitors
US5514555A (en) 1993-03-12 1996-05-07 Center For Blood Research, Inc. Assays and therapeutic methods based on lymphocyte chemoattractants
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
WO1995033462A1 (en) 1994-06-02 1995-12-14 Smithkline Beecham Corporation Anti-inflammatory compounds
JPH089412A (en) 1994-06-22 1996-01-12 Nec Eng Ltd Automatic chrominance signal correcting circuit
US5571775A (en) * 1994-07-11 1996-11-05 Dowelanco N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides
FR2724654B1 (en) 1994-09-16 1997-12-12 Roussel Uclaf NEW GALLIC ACID DERIVATIVES, THEIR PREPARATION PROCESS, THE NEW INTERMEDIATES OBTAINED, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5739333A (en) * 1995-05-16 1998-04-14 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
AU703892B2 (en) * 1995-09-06 1999-04-01 Kowa Co., Ltd. Pyrimidine derivatives
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
US5780488A (en) * 1996-04-03 1998-07-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
DE19629144A1 (en) * 1996-07-19 1998-01-22 Bayer Ag Substituted triazoloazine sulfonamides
ATE360689T1 (en) 1996-09-10 2007-05-15 Kocher Theodor Inst CXCR3 CHEMOKINE RECEPTOR, ANTIBODIES, NUCLIC ACIDS AND METHOD OF USE THEREOF
AR015104A1 (en) * 1996-11-13 2001-04-18 Dowelanco SUBSTITUTED N-ARILSULFYLIMINE COMPOUNDS, USED AS CATALYSTS IN THE PREPARATION OF N-ARYLARILSULFONAMIDE COMPOUNDS; PROCESS TO PREPARE SUCH COMPOUNDS AND ITS USE TO CATALIZE SUCH PREPARATION.
TW523506B (en) * 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
SE9604786D0 (en) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
US6696475B2 (en) * 1997-04-22 2004-02-24 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
WO1998050031A1 (en) 1997-05-07 1998-11-12 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
ES2244082T3 (en) * 1997-07-11 2005-12-01 Smithkline Beecham Plc SULFONAMIDE DERIVATIVES THAT ARE ANTAGONISTS OF THE 5-HT6 RECEIVER AND PROCEDURE FOR PREPARATION.
US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
CA2300197A1 (en) 1997-12-23 1999-07-01 Warner-Lambert Company Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis
ES2317688T3 (en) 1998-01-29 2009-04-16 Amgen Inc. PPAR-GAMMA MODULATORS.
GB9803411D0 (en) 1998-02-18 1998-04-15 Smithkline Beecham Plc Novel compounds
JP4327915B2 (en) * 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 Sulfonamide derivatives
CA2329777A1 (en) 1998-04-27 1999-11-04 Dashyant Dhanak Ccr-3 receptor antagonists
JP2002512997A (en) 1998-04-29 2002-05-08 バーテックス ファーマシューティカルズ インコーポレイテッド Inhibitor of IMPDH enzyme
US6136971A (en) * 1998-07-17 2000-10-24 Roche Colorado Corporation Preparation of sulfonamides
WO2000005214A2 (en) 1998-07-24 2000-02-03 Pfizer Inc. Isoquinolines as urokinase inhibitors
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
TR200102969T2 (en) 1999-04-15 2002-08-21 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors.
MXPA01013199A (en) 1999-06-30 2003-08-20 Tularik Inc COMPOUNDS FOR THE MODULATION OF PPARgamma ACTIVITY.
US7041691B1 (en) * 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
EP1202970A1 (en) 1999-07-30 2002-05-08 Vertex Pharmaceuticals Incorporated Cyclic amine derivatives for the treatment of neurological diseases
AU7080500A (en) * 1999-08-27 2001-03-26 Chemocentryx, Inc. Compounds and methods for modulating cxcr3 function
AU6870500A (en) 1999-09-06 2001-04-10 Takeda Chemical Industries Ltd. Process for the preparation of 2,3-dihydroazepine derivatives
KR100760434B1 (en) 1999-09-17 2007-10-04 밀레니엄 파머슈티컬스 인코퍼레이티드 Benzamides And Related Inhibitors Of Factor Xa
HUP0203954A2 (en) 1999-09-17 2003-03-28 Millennium Pharmaceuticals, Inc. Inhibitors of factor xa
JP2001089412A (en) 1999-09-22 2001-04-03 Otsuka Pharmaceut Co Ltd Benzene derivative or its pharmaceutically acceptable salt
GB9926302D0 (en) 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
AU2001234689A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. Bivalent phenylene inhibitors of factor xa
WO2001057020A1 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. INDOLE AND BENZIMIDAZOLE INHIBITORS OF FACTOR Xa
US20020013314A1 (en) * 2000-02-01 2002-01-31 Bing-Yan Zhu 3,4-dihydro-2H-benzo[1,4]oxazine inhibitors of factor Xa
HUP0300544A3 (en) 2000-02-03 2005-03-29 Eisai Co Ltd Pharmaceutical compositions containing integrin expression inhibitors
GB2359078A (en) * 2000-02-11 2001-08-15 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
AU2001243158A1 (en) * 2000-02-18 2001-08-27 Merck And Co., Inc. Inhibitors of prenyl-protein transferase
IL146010A0 (en) 2000-02-18 2002-07-25 Arch Dev Corp Polyhydroxylated benzene-containing compounds
CO5300399A1 (en) * 2000-02-25 2003-07-31 Astrazeneca Ab HETEROCICLIOCS CONTAINING NITROGEN, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP3842976B2 (en) * 2000-03-17 2006-11-08 富士通株式会社 Distributed feedback semiconductor laser and manufacturing method thereof
WO2001082916A2 (en) * 2000-05-03 2001-11-08 Tularik Inc. Combination therapeutic compositions and methods of use
JP2002031867A (en) * 2000-05-08 2002-01-31 Fuji Photo Film Co Ltd Processing method for silver halide color photographic sensitive material
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
EP1296977A1 (en) * 2000-06-23 2003-04-02 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
EA005976B1 (en) 2000-06-28 2005-08-25 Туларик Инк. Quinolinyl and benzothiazolyl ppar-gamma modulators
AU2001280167A1 (en) 2000-08-31 2002-03-13 Wakunaga Pharmaceutical Co.,Ltd Novel propenohydroxamic acid derivatives
EP1578341A2 (en) 2000-10-11 2005-09-28 Tularik Inc. Modulation of ccr4 function
US20020147198A1 (en) 2001-01-12 2002-10-10 Guoqing Chen Substituted arylamine derivatives and methods of use
AR032230A1 (en) 2001-01-16 2003-10-29 Sumitomo Chem Takeda Agro Co SULFONAMIDE DERIVATIVE CONTAINING AN AGRICULTURAL AND HORTICALLY COMPOSITION
CA2435829A1 (en) 2001-01-25 2002-08-01 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
WO2003099773A1 (en) * 2002-05-24 2003-12-04 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
US6939885B2 (en) 2002-11-18 2005-09-06 Chemocentryx Aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
WO2004058164A2 (en) 2002-12-20 2004-07-15 Tularik, Inc. Asthma and allergic inflammation modulators
US6993400B2 (en) * 2003-03-07 2006-01-31 Xerox Corporation System and method for real-time assignment of jobs to production cells
WO2004099127A1 (en) 2003-05-07 2004-11-18 Novo Nordisk A/S Novel compounds as kinase inhibitors
EP1643960A2 (en) 2003-07-02 2006-04-12 Merck & Co., Inc. Arylsulfonamide derivatives
AU2006204750C1 (en) 2005-01-14 2012-11-01 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
JP4364168B2 (en) 2005-07-11 2009-11-11 アルゼ株式会社 Game machine
WO2007014054A2 (en) 2005-07-22 2007-02-01 Glaxo Group Limted Benzenesulfonamide inhibitor of ccr2 chemokine receptor

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