CN100518684C - Cold circulation microwave tumor therapeutic apparatus - Google Patents
Cold circulation microwave tumor therapeutic apparatus Download PDFInfo
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- CN100518684C CN100518684C CNB2006100857833A CN200610085783A CN100518684C CN 100518684 C CN100518684 C CN 100518684C CN B2006100857833 A CNB2006100857833 A CN B2006100857833A CN 200610085783 A CN200610085783 A CN 200610085783A CN 100518684 C CN100518684 C CN 100518684C
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- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 34
- 230000001225 therapeutic effect Effects 0.000 title claims description 19
- 238000001816 cooling Methods 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims description 26
- 230000008569 process Effects 0.000 claims description 24
- 230000001105 regulatory effect Effects 0.000 claims description 13
- 230000001276 controlling effect Effects 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 239000000523 sample Substances 0.000 claims description 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000002826 coolant Substances 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
- 239000010703 silicon Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 238000009529 body temperature measurement Methods 0.000 description 7
- 230000009849 deactivation Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- CFQGDIWRTHFZMQ-UHFFFAOYSA-N argon helium Chemical compound [He].[Ar] CFQGDIWRTHFZMQ-UHFFFAOYSA-N 0.000 description 2
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- 238000002679 ablation Methods 0.000 description 1
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- 201000008275 breast carcinoma Diseases 0.000 description 1
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- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
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Abstract
A cold-circulation microwave apparatus for treating tumor is composed of a main body with microprocessor chip, microwave generator and voltage regulator, puncture needle connected to microwave generator, cooling system with flow controller, and temp measuring unit with two thermo-sensitive resistors.
Description
Technical field
The present invention relates to a kind of therapeutic instrument, especially a kind of improvement of microwave tumor therapeutic apparatus belongs to the armarium technical field.
Background technology
Malignant tumor is to threaten human health and cause one of main causes of death.In recent years, wound is little, complication is low because of having for the minimally-invasive treatment tumor, the painful characteristics such as few of patient, and obtains extensive concern.This Therapeutic Method is compared with methods such as traditional thermotherapy, radiotherapies, can directly produce the destruction effect to tumor tumor body, easilier reaches similar operating radical cure effect.
At present, the tumor micro-wound therapeutic equipment mainly contains radio frequency, microwave, argon helium knife, focus ultrasonic knife etc.Its treatment mechanism all is under B ultrasonic, CT or MRI guiding, and energy accumulating at tumor tumor body, is made tumor tissues degeneration, necrosis with fixed attention hot or refrigerated method.
Wherein, there are shortcomings such as puncture is inconvenient, damage is big in radio frequency boundling pin in operation process.Argon helium knife, focus ultrasonic knife can not pass the defective of bone treatment except existing, and all the price costliness is difficult to be used widely clinical.Comparatively speaking, the cold circulation microwave cutter is safe, and relapse rate is low, and patient bears gently, therefore has popularizing application prospect preferably.
Understand according to the applicant, mainly by formations such as main frame, the puncture needle (claiming microwave coagulation treatment again) that contains microwave generator spare and temperature measuring equipments, main frame mainly is made of control circuit, power circuit and keyboard/display board circuit existing microwave tumor therapeutic apparatus.Contain little process chip and voltage regulating and controlling circuit in the control circuit, be placed on the focus as the signal output part of the thermocouple of temperature measuring equipment and connect the input of little process chip through A/D converter spare, the control output end of little process chip connects the microwave generator spare of puncture needle through voltage regulating and controlling circuit.
The clinical treatment practice shows, with thermocouple as the thermometric device, temperature signal is sent into little processing (89c51) chip by the A/D conversion, not only accuracy is relatively poor, a little less than the capacity of resisting disturbance, be difficult to satisfy the application demand that temperature is accurately controlled in the microwave therapy apparatus requirement, and because neoplastic lesion tissue and normal structure close relation, only monitor the temperature of affected area, in treatment, can't form ideal abrupt temp field, often damage normal structure unavoidably, phenomenons such as puncture needle skin ambustion often take place, both brought extra misery, be unfavorable for treatment again to patient.
Summary of the invention
The objective of the invention is: at the shortcoming of above prior art existence, a kind of cold circulation microwave tumor therapeutic apparatus that can accurately control temperature is proposed, thereby both guaranteed heat tumor tissues with fixed attention, avoided normal structures such as skin ambustion again, in the hope of reaching best therapeutic effect.
In order to reach above purpose, cold circulation microwave tumor therapeutic apparatus of the present invention by main frame, contain the puncture needle (claiming microwave coagulation treatment again) of microwave generation circuit, the cooling system that connects the puncture needle inlet and temperature measuring equipment and constitute; Described main frame mainly is made of control circuit, power circuit and keyboard/display board circuit, contains little process chip in the described control circuit; Described microwave generation circuit contains voltage regulating and controlling circuit; Described temperature measuring equipment contains the critesistor of two independent distribution at least, and one of them is used to be placed near the focus, and another is placed on the shank of puncture needle; Described cooling system contains flow control device; The signal output part of described critesistor connects the corresponding input of little process chip respectively, first control output end of described little process chip connects the voltage regulating and controlling circuit of the microwave generation circuit of described puncture needle, and second control output end connects the flow control device of cooling system.
After adopting cold circulation microwave tumor therapeutic apparatus of the present invention, not only temperature measurement accuracy improves greatly, capacity of resisting disturbance is strong, and can monitor the temperature at focus and skin place, by respectively to the accurate control of output voltage and coolant rate, form ideal temperature field, increase cold circulatory function, effectively reduced the bar temperature of puncture needle, when heat is coagulated tumor tissues, reliably avoid normal structures such as skin ambustion, thereby reach best therapeutic effect.
Description of drawings
The present invention is further illustrated below in conjunction with accompanying drawing.
Fig. 1 is the entire block diagram figure of one embodiment of the invention.
Fig. 2 is the circuit theory diagrams of control circuit among Fig. 1 embodiment.
Fig. 3 is the microwave generation circuit theory diagrams that Fig. 1 embodiment contains regulating circuit.
Fig. 4 is the display circuit schematic diagram of Fig. 1 embodiment.
Fig. 5 is the puncture needle structural representation of Fig. 1 embodiment.
The specific embodiment
Embodiment one
The microwave therapy apparatus of present embodiment is made of main frame, puncture needle, cooling system and temperature measuring equipment as shown in Figure 1.Main frame connects the puncture needle that contains microwave generator spare by coaxial cable, and cooling system connects the inlet and the liquid outlet of puncture needle, forms cool cycles, and temperature measuring equipment, is placed in respectively on focus tumor tissues and the puncture needle as sensor probe with critesistor.
Main frame mainly is made of control circuit, power circuit and keyboard/display board circuit.Wherein, control circuit contains two and the little process chip U1 of 89C4051 and the U9 that connect as shown in Figure 2.Temperature measuring equipment adopt measuring range at-50 ℃～150 ℃, precision at the critesistor of ± 0.1 ℃ of NTC as temperature element, be placed in respectively on focus and the shank, the temperature measurement signal of one of these two independent distribution critesistor output is by the 1 foot input of plug receptacle JP3, through the input of 2 feet, the output of 6 feet of amplifier U5, be exaggerated the 6 feet input of back by TLC25431 modulus conversion chip U2; The temperature measurement signal of another critesistor output is input to 7 feet of TLC25431 modulus conversion chip U2 through 7 feet of plug receptacle JP3.This two temperature measurement signal from the output of 16,18 feet, is input to 17 feet of little process chip U1 and 14 feet of U9 respectively, and by its 7 foot and 8 feet control signal is outputed to 4 feet and 5 feet of plug receptacle JP1 respectively with low level through diode D7, D8 after the U2 analog digital conversion.By JP1 this two control signal is outputed to the microwave generation regulating circuit (referring to Fig. 3) of puncture needle and the flow control device of cooling system respectively.
In addition, also contain following auxiliary circuit among Fig. 2:
1, power circuit---D1, U7, U8 regulator rectifier circuit by Fig. 2 upper left corner constitute, and provide power supply to each device.
2, discharge circuit---2904 four high guaily unit chip U6 by Fig. 1 upper right corner constitute.Amplifier outfan 5 feet of modulus conversion chip U2 are connected with 5 feet with input 3 feet of amplifier chip U6 through capacitance resistance ware respectively, and outfan 1 foot of U6 chip and 7 feet are 5 feet and 6 feet of tieback modulus conversion chip U2 respectively.Like this, can improve signal accuracy, help accurately controlling temperature.
3, anti-voltage-multiplying circuit---mainly 7660 anti-multiplication of voltage chip U4 by Fig. 1 lower right corner constitute, and its effect provides negative voltage and gives U5 and U10 chip.After the positive voltage signal that is provided by circuit enters into U4,, output to the 4th foot of U5 and U10, supply its negative voltage signal through amplifying oppositely.
4, voltage stabilizing reference circuit---audion TL431 adjustable potential meter and the capacitor element extremely on every side by the U4 right side combines, and can adjust supply voltage by regulating the adjustable potential meter, and make the stable output of voltage.
5, watchdog circuit---the X5045 storage chip U3 by the U1 lower left constitutes, and is used for the locking storage.
Microwave generation circuit as shown in Figure 3, the power supply in the upper left corner is coupled through the former limit of the transformator T3 magnetron M1 with this transformator secondary.The upper right corner is inserted voltage regulating and controlling circuit from the Regulation Control signal of control circuit by plug receptacle J5, J6, connect the control utmost point of controllable silicon U1 through photoelectrical coupler U2, described silicon controlled output is connect the former limit of transformator T3 by plug receptacle, thereby regulate the microwave emission voltage that magnetron M1 outputs to antenna J7 according to the control signal of little process chip output, reach the purpose of control affected area temperature.
Charactron in the display circuit among Fig. 4 connects the display prot of little process chip through display driver chip by plug receptacle, and is same as the prior art, so do not describe in detail.
As seen from Figure 5, microwave antenna 4 is housed in the needle point of puncture needle, the rear end of this microwave antenna is connected with coaxial cable 9.Be shaped on ring cavity 7 in the shank.Pin is the external coolant circulation pump of last inlet, and liquid outlet is communicated with cavity 7, external discharging tube.Ring cavity 7 internal fixation in shank around the microwave antenna 4 have the capillary tube 8 that is communicated with inlet.Be fixed on the front end of ring cavity 7 in the shank as the critesistor 10 of temperature probe, the holding wire of the signal output part of this temperature probe in being placed in coaxial cable 9 is connected to the plug receptacle JP3 of Fig. 2, and the precision of measuring temperature can reach ± and 0.1 ℃.
During work, concrete measuring and controlling temp process is as follows: be positioned at 1,2 two that two temperature-measuring thermistor lines on focus and the shank meet plug receptacle JP3, because critesistor has the characteristic with temperature rising resistance decreasing, the voltage that therefore is added in two ends can reduce along with the increase of temperature.The thermometric voltage signal enters 2,3 feet that the OP07 signal amplifies chip U5 through resistance, is exported by the 6th foot through amplifying the back.5,6 feet that then enter into TLC2543I chip U2 carry out the A/D conversion, receive 17 feet of the 89C4051 chip of little process chip U1 of main control or U9 again.
Through this transfer of data, temperature measurement data enters into mastery routine, after the analysis of program to data, outputs to display circuit, thereby demonstrates the measured temperature value of temperature probe.Little process chip compares and measures temperature and preset temperature simultaneously, and according to comparative result output control signal corresponding, the microwave emission voltage of control puncture needle, the temperature of regulating affected area; And control the pump discharge that connects cooling system, regulate the temperature of puncture needle to normal structures such as skins.
Owing to adopted responsive critesistor, and by two groups of little process chip the temperature of focus and normal structure is rationally controlled respectively, therefore temperature measurement accuracy can form the abrupt temp field of normal structure to tumor tissues up to ± 0.1 ℃, thereby obtains optimum therapeuticing effect.
Clinical treatment proves that the microwave therapy apparatus of present embodiment has the following advantages:
1, except that the deactivation effect, suppress effect in addition---under B ultrasonic, CT, MRI or X-ray guiding, behind puncture needle (claiming microwave coagulation treatment again) implantation tumour tumor body, can make polar molecule high-speed motion friction under the effect of microwave field wherein produce heat, because temperature precise control, therefore the protein denaturation of tumor cell is solidified, contrary downright bad, and the tumor tissues of deactivation can be produced heat shock protein, stimulate the immune system of body, improve body's immunological function, play the effect that suppresses the tumor cell diffusion.
2, ablation range is big---and owing to the effective control to cooling system, needn't worry that normal structure is impaired, therefore can give full play to microwave usefulness, make the tumor solidification treatment faster, the deactivation scope is bigger, but the tumor of original position deactivation 5cm diameter.
3, patient bears gently in the art---and the high bar temperature of traditional microwave puncture needle stimulates tissues such as Glisson's capsule, patient's pain is strong in the art, often force operation to pause, sometimes have to solve with general anesthesia, and present embodiment can guarantee that the bar temperature of puncture needle is no more than body temperature, in the art patient bear gently, painful few, can scalded skin.
4, safe---the high precision measuring temperature system can realize the lip temperature of synchronizing detection and control tumor core under the state that does not cut off microwave output; obtain certain deactivation data; temperature measurement accuracy is up to ± 0.1 ℃; safety protection function is strong; the reliability height; the needle track wound is little, goes out insufficiency of blood, and healing is fast.
5, the scope of application is wide---and not only can be used for hepatocarcinoma, also can be used for pulmonary carcinoma, the treatment of solid tumors such as breast carcinoma, cancer of pancreas, carcinoma of prostate, osteocarcinoma, hysteromyoma.
In addition to the implementation, the present invention can also have other embodiments.For example, the flow control device of cooling system can be the buncher that drives coolant pump, also can be flow control valve in the cooling line or the like,
All employings are equal to the technical scheme of replacement or equivalent transformation formation, all drop on the protection domain of requirement of the present invention.
Claims (8)
1. a cold circulation microwave tumor therapeutic apparatus is made of main frame, the puncture needle that contains microwave generation circuit, the cooling system that connects the puncture needle inlet and temperature measuring equipment; Described main frame mainly is made of control circuit, power circuit and keyboard/display board circuit, contains little process chip in the described control circuit; Described microwave generation circuit contains voltage regulating and controlling circuit; It is characterized in that: described temperature measuring equipment contains the critesistor of two independent distribution at least, and one of them is used to be placed near the focus, and another is placed on the shank of puncture needle; Described cooling system contains flow control device; The signal output part of described critesistor connects the corresponding input of little process chip respectively, first control output end of described little process chip connects the voltage regulating and controlling circuit of the microwave generation circuit of described puncture needle, and second control output end connects the flow control device of cooling system.
2. according to the described cold circulation microwave tumor therapeutic apparatus of claim 1, it is characterized in that: also contain the discharge circuit that constitutes by the amplifier chip, the signal output of described critesistor connects the corresponding input of little process chip through modulus conversion chip, the amplifier outfan of described modulus conversion chip is connected through the input of capacitance resistance ware with the amplifier chip, the outfan tieback modulus conversion chip of described amplifier chip.
3. according to the described cold circulation microwave tumor therapeutic apparatus of claim 1, it is characterized in that: described control circuit contains two and little process chip of connecing, and its input connects respectively and is used to be placed near the focus and is placed in critesistor on the shank of puncture needle; Described input termination is placed near the control output end of little process chip of the critesistor focus as first control output end, connects the voltage regulating and controlling circuit of the microwave generation circuit of described puncture needle; Described input termination is placed in the control output end of little process chip of critesistor on the puncture needle shank as second control output end, connects the flow control device of cooling system.
4. according to claim 2 or 3 described cold circulation microwave tumor therapeutic apparatus, it is characterized in that: the power supply of described microwave generation circuit is through the former limit of transformator and the magnetron coupling of this transformator secondary, Regulation Control signal from control circuit connects the silicon controlled control utmost point in the voltage regulating and controlling circuit through photoelectrical coupler, and described silicon controlled output is by the former limit that connects described transformator.
5. according to the described cold circulation microwave tumor therapeutic apparatus of claim 4, it is characterized in that: in the needle point of described puncture needle microwave antenna is housed, the rear end of described microwave antenna is connected with coaxial cable.
6. according to the described cold circulation microwave tumor therapeutic apparatus of claim 5, it is characterized in that: be shaped on ring cavity in the shank of described puncture needle, pin is the external coolant circulation pump of last inlet, and liquid outlet is communicated with described cavity, external discharging tube.
7. according to the described cold circulation microwave tumor therapeutic apparatus of claim 6, it is characterized in that: the ring cavity in the shank of described puncture needle is fixed with the capillary tube that is communicated with inlet, is fixed on the front end of ring cavity in the shank as the critesistor of temperature probe.
8. according to the described cold circulation microwave tumor therapeutic apparatus of claim 7, it is characterized in that: the holding wire of the signal output part of described temperature probe in being placed in coaxial cable is connected to little process chip.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100857833A CN100518684C (en) | 2006-06-30 | 2006-06-30 | Cold circulation microwave tumor therapeutic apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100857833A CN100518684C (en) | 2006-06-30 | 2006-06-30 | Cold circulation microwave tumor therapeutic apparatus |
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| CN1868415A CN1868415A (en) | 2006-11-29 |
| CN100518684C true CN100518684C (en) | 2009-07-29 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972188A (en) * | 2010-11-10 | 2011-02-16 | 韩俊江 | Precise temperature-controlling tumor therapeutic apparatus and control method thereof |
| CN104224434B (en) * | 2010-11-10 | 2016-09-14 | 余丽 | Accurate temperature control tumor therapy instrument |
| CN102551873A (en) * | 2010-12-10 | 2012-07-11 | 韩俊峰 | Accurate temperature control tumor therapeutic apparatus and control method thereof |
| CN106037929B (en) * | 2016-05-23 | 2019-07-26 | 方崇亮 | A kind of color ultrasound imaging microwave therapeutic system and microwave radiation probe recognition method |
| US20210361353A1 (en) * | 2017-08-31 | 2021-11-25 | Covidien Lp | Systems and methods for sensing temperature at different locations on a microwave antenna using ultiple fiber sensors |
| CN114191718B (en) * | 2022-02-16 | 2022-11-08 | 杭州维纳安可医疗科技有限责任公司 | Electric field generating electrode paste and tumor electric field treatment device |
| CN114886553A (en) * | 2022-05-23 | 2022-08-12 | 南京诺源医疗器械有限公司 | Temperature control method and device, electronic equipment and storage medium |
| CN115220488B (en) * | 2022-06-28 | 2023-11-21 | 广东花至美容科技有限公司 | Bionic skin temperature control method and device |
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|---|---|---|---|---|
| US4140130A (en) * | 1977-05-31 | 1979-02-20 | Storm Iii Frederick K | Electrode structure for radio frequency localized heating of tumor bearing tissue |
| US4204549A (en) * | 1977-12-12 | 1980-05-27 | Rca Corporation | Coaxial applicator for microwave hyperthermia |
| WO1981003616A1 (en) * | 1980-06-17 | 1981-12-24 | T Sandhu | Microwave antenna system for intracavitary insertion |
| CN1064623A (en) * | 1991-03-14 | 1992-09-23 | 天津大学 | Microwave heat therapeutic machine for internal cavity of human body |
| US5649973A (en) * | 1992-11-13 | 1997-07-22 | Dornier Medical Systems, Inc. | Thermotherapy method with tissue cooling |
| US6690976B2 (en) * | 2000-04-13 | 2004-02-10 | Celsion Corporation | Thermotherapy method for treatment and prevention of breast cancer and cancer in other organs |
| CN1658803A (en) * | 2002-03-20 | 2005-08-24 | 福加齐·迪·文图雷利·安德烈亚&C.Snc公司 | Catheter with flexible cooled electrode |
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2006
- 2006-06-30 CN CNB2006100857833A patent/CN100518684C/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140130A (en) * | 1977-05-31 | 1979-02-20 | Storm Iii Frederick K | Electrode structure for radio frequency localized heating of tumor bearing tissue |
| US4204549A (en) * | 1977-12-12 | 1980-05-27 | Rca Corporation | Coaxial applicator for microwave hyperthermia |
| WO1981003616A1 (en) * | 1980-06-17 | 1981-12-24 | T Sandhu | Microwave antenna system for intracavitary insertion |
| CN1064623A (en) * | 1991-03-14 | 1992-09-23 | 天津大学 | Microwave heat therapeutic machine for internal cavity of human body |
| US5649973A (en) * | 1992-11-13 | 1997-07-22 | Dornier Medical Systems, Inc. | Thermotherapy method with tissue cooling |
| US6690976B2 (en) * | 2000-04-13 | 2004-02-10 | Celsion Corporation | Thermotherapy method for treatment and prevention of breast cancer and cancer in other organs |
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