CN101065077A - 一种带纤毛的类支架系统 - Google Patents

一种带纤毛的类支架系统 Download PDF

Info

Publication number
CN101065077A
CN101065077A CNA2005800401468A CN200580040146A CN101065077A CN 101065077 A CN101065077 A CN 101065077A CN A2005800401468 A CNA2005800401468 A CN A2005800401468A CN 200580040146 A CN200580040146 A CN 200580040146A CN 101065077 A CN101065077 A CN 101065077A
Authority
CN
China
Prior art keywords
method further
polymer
tract
movable parts
pliable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800401468A
Other languages
English (en)
Inventor
W·丹尼尔·希尔利斯
穆里尔·Y·伊什克瓦
克拉伦斯·T·特格林
理察·威尔逊
小洛厄尔·L·伍德
维多利亚·Y·H·伍德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Searete LLC
Original Assignee
Searete LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searete LLC filed Critical Searete LLC
Publication of CN101065077A publication Critical patent/CN101065077A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958Inflatable balloons for placing stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/043Bronchi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/046Tracheae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2002/065Y-shaped blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy

Abstract

一种带纤毛的类支架系统及其操作方法。

Description

一种带纤毛的类支架系统
相关申请的交叉引用
本申请涉及下列申请的所有主题,从中要求最早的可获得的有效的申请日(例如,要求不同于临时专利申请的最早的优先权日;要求35USCξ119(e)下的关于临时专利申请的权益),并将下列申请的所有主题以引用方式整体并入本申请;本申请也要求下列申请的任一及全部在先申请(parent、grandparent、great-grandparent,etc.applications)的所有主题的最早的可获得的有效的申请日,并也将这些申请的所有主题以引用方式整体并入本申请:
1.2004年4月19日提交并确定美国申请号USAN 10/827,576的题为一种灌注操作系统的美国专利申请,发明人名为Lowell L.Wood Jr.。
2.2004年4月19日提交并确定美国申请号USAN 10/827,578的题为一种具有传感器的灌注操作系统的美国专利申请,发明人名为Lowell L.WoodJr.。
3.2004年4月19日提交并确定美国申请号USAN 10/827,572的题为一种具有容器的灌注操作系统的美国专利申请,发明人名为Lowell L.WoodJr.。
4.2004年4月19日提交并确定美国申请号USAN 10/827,390的题为一种伸缩灌注操作系统的美国专利申请,发明人名为Lowell L.Wood Jr.。
技术领域
本申请大体涉及用于治疗和/或管理疾病、病症或疾患的内置人工(endoprosthetic)装置。
发明概述
一方面,一种装置,包括但不限于:具有外表面和内表面的柔韧中空部分,其中所述柔韧中空部分被裁定大小以放入接受者体内的一个部位中;和连接至所述柔韧中空部分内表面的多个可活动部件,这些可活动部件可作为一个组进行操作来移动颗粒。除了前述的之外,其它的方法方面在组成本申请一部分的权利要求、附图、和正文中描述。
一方面,一种方法,包括但不局限于:组成可植入动物中的支撑通道;将多个可活动部件连接至所述的支撑通道;并裁定所述支撑通道和所述多个可活动部件的大小以放入动物体内的一个部位。除了前述的之外,其它的方法方面在组成本申请一部分的权利要求、附图、和正文中描述。
一方面,一种方法,包括但不局限于:将中空可膨胀部件放入接受者的腔道部分中,其中所述的中空可膨胀部件内部与多个活动条相连;将所述的中空可膨胀部件置于器官的管腔中;并监控所述的中空可膨胀部件。除了前述的之外,其它的方法方面在组成本申请一部分的权利要求、附图、和正文中描述。
在一个或多个不同的方面,相关的系统,包括但不局限于用于实现此处参考的方法方面的电路和/或程序设计;所述的电路和/或程序设计实际上可以是根据系统设计者的设计选择而配置以实现此处参考方法方面的任何硬件、软件、和/或固件的组合。
在一个或多个不同的方面,相关的系统,包括但不局限于用于实现此处参考的方法方面的能量和动力(power)管理回路和/或程序设计;所述的回路和/或程序设计实际上可以是根据系统设计者的设计选择而被配置来实现此处参考方法方面的任何硬件、软件、和/或固件的组合。
除了前述的之外,提出了不同的其它方法和或系统方面并在本申请的正文(例如,权利要求和/或发明详述)和/或附图中描述。
前述的是概述并因此由于需要而包含对细节的简化、概括和省略;所以,本领域技术人员会理解,这种概述仅用于说明而非意欲以任何方式进行限制。正如权利要求书所单独限定的,此处描述的装置和/或方法的其它方面、发明特征、和优点将在本文的非限制性的发明详述中变得明显。
附图简述
图1是带有纤毛的类支架系统100的一个实施方案的平面图。
图2是带有纤毛的类支架系统100的不同实施方案的平面图。
图3是一个方面的带有纤毛的类支架系统100的截面图。
图4是一个方面的带有纤毛的类支架系统100的截面图。
图5是一个方面的带有纤毛的类支架系统100内部纤毛运动的简图。
图6是一个方面的带有纤毛的类支架系统100内部纤毛运动的简图。
图7是植入气管或支气管树部分701的带有纤毛的类支架系统100的示图。
在不同的附图中使用的相同的符号一般表示类似或相同的部件。
发明详述
本申请使用提纲标题的形式清楚陈述。然而,应该理解提纲标题是出于陈述的目的,并且可以在整个申请中讨论不同类型的主题(例如,装置/结构可在方法/操作标题下讨论,和/或方法/操作可在结构/方法标题下讨论)。因此,提纲标题形式的使用非意欲以任何方式进行限制。
1.纤毛类支架系统和/或方法。
当前参考图1,表示的是各种示例性纤毛类支架系统和/或方法的侧平面示图。相应地,本申请首先描述图1的某些具体的示例性结构;其后,本申请举例说明了某些具体的示例性方法。本领域技术人员将理解此处描述的具体装置、系统和方法仅意欲作为其一般装置、系统和方法的举例说明。
本领域技术人员还将理解,在一个实施方案中,本发明的纤毛类支架系统包括一种带动力的纤毛类支架系统。此外,当结构作为纤毛类支架系统被提及时,非意欲限制该术语。术语类支架系统可指,例如可包括为管通气口提供支撑的任何结构或装置的支架或类似装置,例如细长棒、螺纹、或导管。
A.结构和或装置
参考附图,并且当前参考附图1,表示的是带有纤毛的类支架系统100的平面图。所述的带有纤毛的类支架系统100是可用于受体、接受者或宿主(例如动物)中的内置人工装置。一方面,带有纤毛的类支架系统100可插入穿过组织或器官或其部分的管道的管腔中。所述的带有纤毛的类支架系统100的表面可包括藉以与动物管壁连接或与动物管壁定位接触的表面改性。例如,所述的表面改性可包括凸起101、环、沟、脊或回路,其中一个或多个可以是动力驱动的。一方面,带有纤毛的类支架系统100是具有实际上中空内部的纵向或长的装置。带有纤毛的类支架系统100可作为管腔内的人工装置来修复、打开、排空、代替、药物治疗或支撑接受者体内的管腔。例如,穿过组织或器官的管道的管腔可以是脉管系统的一部分、神经脉管系统、泌尿生殖管道、肺部管道、胃肠道、或任何其它有管腔穿过的组织或器官或其部分。
参考附图,并且当前参考附图2,描述的是各种带有纤毛的类支架系统100的平面图。一方面,带有纤毛的类支架系统100可具有开放的结构。另一方面,带有纤毛的类支架系统100可具有柔韧的、可压缩的或易膨胀的结构。带有纤毛的类支架系统100可以自膨胀、球囊膨胀、在包埋式控制器控制下膨胀或收缩。膨胀的实现可通过例如加入膨胀性材料或特定的结构,或其组合。例如,所述的膨胀性材料包括但不局限于镍-钴-铬合金或钛。此外,膨胀性的获得也可通过使用线圈或类弹簧结构,或经由多种类型动力部件或机械部件中的任一种。
继续参考附图2,另一方面,带有纤毛的类支架系统100可具有开放的柔韧结构。此类结构将允许带有纤毛的类支架系统100的最小化以便插入。带有纤毛的类支架系统100被插入某部位后可膨胀来提供支撑。带有纤毛的类支架系统100的形状或类型可取决于其使用的部位。例如,带有纤毛的类支架系统100可具有螺旋线圈形状(附图2A和2B)、管网形状(附图2C)、分两叉的形状(附图2D)、不规则的Y形或包括锥形(taper)在内的长分段形状(附图2E)。一方面,带有纤毛的类支架系统100可由单线形成,或具有开放的格或网结构。其它的信息可在例如美国专利第5,395,390和5,234,457号中找到,特此将两者以引用方式整体并入本文。一方面,带有纤毛的类支架系统100可包括,例如,用于提升弹性并更紧密粘附至管腔的分段结构。另一方面,带有纤毛的类支架系统100可包括,例如,用于增强支撑和/或清除阻塞物质的一个或多个可膨胀的分叉或分枝。另外,带有纤毛的类支架系统100可包括附属部件,包括但不局限于排空部件、虹吸管、传感器、驱动器、储物部件、释放存储物的部件、控制器或提供遥测解决方案的部件。
带有纤毛的类支架系统100的某些或全部部件(例如组织接触部件)可由生物相容性材料、形状记忆材料或金属制成,如镍钛合金、金属、硅、塑料或聚合物。聚合物的实例包括但不局限于聚乙烯、聚丙烯、聚乙醇酸、聚乳酸、醋酸纤维素或硝酸纤维素。一方面,带有纤毛的类支架系统100的某些或全部部件可由可生物降解的材料制成。另一方面,带有纤毛的类支架系统100可以一种或多种例如生物相容的、有机的或可生物降解的聚合物或材料涂布。
此外,带有纤毛的类支架系统100可用于递送试剂,例如,包括但不局限于,通过被动递送或在所述的带有纤毛的类支架系统100内部或外部的控制器控制下递送。一方面,当通过被动递送来递送试剂时,带有纤毛的类支架系统100可以一种或多种试剂涂布,例如,包括但不局限于药物、药剂、治疗剂、生物活性剂、化学品、化合物、表面活性剂、类固醇、腔道膨胀剂、腔道收缩剂、抗生素或抗真菌或抗病毒剂、蛋白质、核酸或由一种或多种核酸组成的聚合物、大分子或肽。
一方面,将带有纤毛的类支架系统100裁定大小放入接受者中,例如,包括但不局限于放入成年人体的血管管腔中。另一方面,将带有纤毛的类支架系统100裁定大小放入例如小儿体内器官的管腔中。在一个实施例中,支架的直径大小可大约是1-2cm。在另一个实施例中,带有纤毛的类支架系统100的外部和内部直径都可以是固定的或可以变动以适应插入部位的尺寸、功能赋予部件的放置或所述的纤毛类支架系统100的功能。在另一个实施例中,可将带有纤毛的类支架系统100裁定大小以安装至支气管树的一个部位内,其中所述的支气管树部位的内部直径大约是0.1-10mm。本发明的范围还包括,带有纤毛的类支架系统100可用于全部或部分地代替所述的支气管树的段部分的功能。在此实施例中,所述的带有纤毛的类支架系统100的外部直径具有相应于所述支气管树部分的外部直径左右的直径。
当前参考附图3,以及参考附图4,描述的是一个方面的带有纤毛的类支架系统100的横截面图。一方面,带有纤毛的类支架系统100可具有由金属制成的并且使用聚合物涂布的外表面312。外表面312可具有比内表面311更低或更高的摩擦系数,促进了带有纤毛的类支架系统100的外表面312与例如管腔结合壁的粘连。外表面312也可包括表面突起物101以例如将带有纤毛的类支架系统100定位或粘附至例如管腔的结合壁。内表面311可具有低摩擦系数以促进空气、流体、碎片、流化态粒子、渗出液、颗粒、粘液或碎片的流动。内表面311可以是光滑的以减少物质的附着或粘连,从而减少阻塞。外表面312的总摩擦系数仅需要是足以使本发明装置合理地固定和/或定位于一个区域内且使不期望的迁移最小化的数值。因此,对于带有纤毛的类支架系统100,摩擦系数的值将会改变并在一个实施例中取决于其应用或意欲应用的部位。本领域已知例如聚四氟乙烯(teflon)涂布的表面的摩擦系数大约是0.05,皮肤的摩擦系数大约是0.8,以及钢的摩擦系数大约是0.58。在一个示例性的方面,内表面311的摩擦系数在0.0001至大约0.58之间,而外表面312的摩擦系数至少大约是0.0001。在其它的申请或其它的方面,内表面311的摩擦系数和外表面312的摩擦系数可不同于这些范围,并且这些范围不应该被认为是限制性的。
一方面,带有纤毛的类支架系统100具有多个排列在带有纤毛的类支架系统100内表面311的纤毛320和321。多个纤毛可包括一个或多个联接于带有纤毛的类支架系统100的可活动部件。一方面,多个纤毛320和321可以例如以行、列或类似顺序的分组进行排列。多个纤毛320和321可完全或部分覆盖内表面311。一方面,纤毛的长度、尺寸或其它的结构方面将取决于纤毛预期的功能。例如,当与肺部有关的带有纤毛的支架应用于气管或支气管中时,纤毛的活动可帮助降解阻塞物或减少阻塞物的形成。在此实施例中,纤毛可以是长的,纤毛的波状运动可负责移动、排出(expelling)或推进(propelling)例如液体、凝块、阻塞物质或流体、颗粒、流化态粒子、粘液、渗出液或生物碎片。另一方面,多个纤毛320和321可以是适于操作波状推进机械装置的不同长度纤毛的组合。本领域技术人员会理解,所述的多个纤毛320和321包括但不局限于类似纤毛功能的结构和/或类似纤毛表观的(appearing)结构。
一方面,多个纤毛320和321可在带有纤毛的类支架系统100的内表面311上排列。然而,在外表面312或两个表面上同时包括多个纤毛320和321也在本发明的范围之内。本发明的范围还包括在外表面312或内表面311上存在的多个纤毛320和321可以不同,例如,在纤毛类型、与纤毛相关的控制机械部件和/或由多个纤毛320和321执行的功能方面不同。例如,外表面311上存在的多个纤毛320和321可以是一个类型或具有帮助带有纤毛的类支架系统100放置入接受者特定部位的特征,而内表面312上存在的多个纤毛320和321可以是一个类型或具有执行其它功能的特征。
当前参考附图5,一方面,多个纤毛320和321可包括由自振荡聚合物凝胶制备的驱动器。其它的信息可在O.Tabata,H.Hirasawa,K,和S.Aoki第14届微机电系统国际年会上的论文″Ciliary Motion Actuator usingSelf-Oscillating gel.″(2001年,第405-408页)中找到,此处将其以引用方式并入本文。另一方面,多个纤毛320和321都可由自振荡聚合物凝胶制备。所述的自振荡聚合物凝胶表现出自发的膨胀520和退胀521并负责传送波动。纤毛运动包括但不局限于上下、波状、波样(wave like)、脉冲、矢量、振荡、循环、横向、垂直、节律或侧面运动等。纤毛运动不需局限于较大的运动,也可包括纳米水平的运动。
纤毛运动可能是自传导或被诱导的。例如,对于肺部带纤毛的支架,当颗粒碰触到纤毛时或当患者咳嗽或其它活动或驱动他/她的胸腔时,可产生诱导。驱动可利用例如来自之前动作所储存的能量;在肺部案例中,例如,所述动作可以是与吸入和/或呼出相关的或与心肌运动相关的那些动作。带有纤毛的类支架系统100可以是部分一次性的支架,例如,其中支架的大部分是由可生物降解的或其它在体内被溶解或分解的材料组成。本领域技术人员应该理解,从自振荡聚合物凝胶制作此类纤毛的技术是众所周知的并在此处以引用方式并入本文。本领域技术人员还会理解,特别当可以获得动力来源时,帮助纤毛驱动的传送以相反方向沿着支架进行的技术是已知的并且在此处以引用方式并入本文。
另一方面,多个纤毛310和321包括一个或多个柔韧的聚合棒。其它的信息可在由R.L.Carroll,B.Wilde,R.M.Taylor,L.Vicci,S.Washburn和R.Superfine在2003年11月6-8日召开的美国物理学会东南分会的第70届年会上做的题为″Biomimetic Flexible Polymer Rods-Artificial Cilia.″的报告中找到。模仿纤毛结构的聚合棒是已知的结构。所述的聚合棒可具有大约10微米的长度和大约800nm的直径并且将能够推进流体、流化态粒子、粘液、渗出液或生物碎片。然而,不同尺寸的聚合棒在本发明的范围内。在一个实施例中,一个或多个柔韧的聚合棒包括磁性材料。例如,外部的振荡磁场可直接或通过与支架内能量储存和/或动力供应的诱导性偶合来操纵或驱动所述的柔韧聚合棒。本领域技术人员应该理解此类技术和类似技术是已知的,并且在此处以引用方式并入本文。
另一方面,多个纤毛320和321包括一个或多个MEMS微驱动器阵列。本领域技术人员应该理解,一个或多个MEMS微驱动器阵列可以被制造以运行各种方式的振荡运动并且能够被包含在带有纤毛的类支架系统100的内部以例如提供力量来移动流体、粒子、流化态粒子、粘液、渗出液或生物碎片穿过带有纤毛的类支架系统100的内部。本领域技术人员应该理解MEMS的制造和驱动技术是本领域已知的,并且在此处以引用方式并入本文。
当前参考附图6,一方面,多个纤毛320和321以例如集中组或阵列620的方式排列。每个纤毛可具有例如经改性的桨形结构,用于有效移动流体、流化态粒子、颗粒、粘液、渗出液或生物碎片。
一方面,多个纤毛310和321或阵列620包括一个或多个驱动器阵列,例如MEMS驱动器阵列。MEMS驱动器阵列可被涂布一薄层改善阵列物理、化学或电学特性的材料,例如包括但不局限于聚酰亚胺。MEMS驱动器阵列可使用热量和静电控制机制来提高小物体的无传感器操纵。一方面,MEMS驱动器阵列可以被排列在例如包括但不局限于带有纤毛的类支架系统100的内表面311上。驱动器阵列可以有能力提供多种动作,例如、平移、旋转、定心或定位。此外,它们可诱导多个纤毛320和321的低水平步态,例如导致流体、粒子、流化态粒子、粘液、渗出液或生物碎片被移动的上下运动、循环运动或鞭打运动。在此实施例中,移动流体、粒子、流化态粒子、粘液、渗出液或生物碎片的速度取决于驱动器每次循环的移位、每单位时间循环重复的次数、被移动颗粒的表面性能、被移动颗粒的重量、局部的表面张力、相对于重力方向或其它加速场的局部定向等。在另一个实施例中,一个或多个MEMS驱动器阵列可用于诱导高水平的控制或高水平的步态,例如定向并对准流体、粒子、流化态粒子、粘液、渗出液或生物碎片。在此实施例中,一个或多个MEMS驱动器阵列可用于定位或旋转阻塞或阻断的颗粒以使其从管腔中排除或清除。本领域技术人员应该理解此类技术是本领域已知的并且在此处以引用方式并入本文。其它的信息可在W.Suh,R.B.Darling,K.F.Bōhringer,B.R.Donald,H.Baltes,G.T.A.Kovacs的文章″Fully Programmable MEMS Ciliary Actuator Arrays forMicromanipulation Tasks.″(IEEE机器人和自动化国际大会(ICRA),第1101-1108页,San Francisco,CA,2000年4月)中找到,此处以引用方式并入本文。
继续参考附图6,在一个实施例中,多个纤毛320和321可例如按程序化的或其它方式控制的节律活动。多个纤毛320和321可从中部静止位置伸展至向上的伸展位置621,在返回中部静止位置前伸展至向下的位置623。在另一个实施例中,多个纤毛320和321的静止位置可以是向下的位置623。多个纤毛320和321的其它同步或不同步蠕动(beating)的组合属于本发明的范围之内,包括那些将纤毛动作的一个或多个波沿着相对于支架局部轴线的某些选定方向传送的组合。
另一方面,多个纤毛320和321可包括马达用以提供能量或产生移动流体、粒子、流化态粒子、粘液、渗出液或生物碎片或流体所需的力量。在一个实施例中,蛋白质分子马达,例如使用驱动蛋白或动力蛋白的那些分子马达,可用于提供纤毛旋转或定向运动的动力。例如,包括但不局限于,生物分子马达的运动方向受任何存在的微管蛋白的导向或可用作为马达轨道的基质的影响。一方面,ATP水解可提供驱动生物分子马达的能量,并且可通过例如将线粒体偶合至生物分子马达来提供ATP和ATP酶。在另一个实施例中,肌动蛋白-肌球蛋白系统可被包括在多个纤毛320和321中以提供用于移动流体、粒子、流化态粒子、粘液、渗出液或生物碎片的力量。本领域技术人员应该理解此类技术是本领域已知的并且以引用方式并入本文。这个主题在下述文献中有进一步的描述:N.Thomas和R.A.Thornhill,Journal of Physics D:Applied Physics 31,253-266页,1998年2月7日;Carlo Montemagno、George Bachand、Scott Stelick和Marlene Bachand,Nanotechnology 10:225-231,1999;两篇文献以引用方式并入本文。
另一方面,多个纤毛320和321包括具有电活性聚合物的电活性传感器,所述电活性聚合物感应电场而偏移。在一个实施例中,所述电活性聚合物的偏移可操作来移动流体。在另一个实施例中,所述电活性聚合物的偏移可操作以移动流体、粒子、流化态粒子、粘液、渗出液或生物碎片,例如,凝结或成块的流体。所述的传感器包括至少两个与电活性聚合物进行电子传递的电极。电活性聚合物的偏转可产生一系列的动作,包括但不局限于一次或多次的旋转、振动、线性、鞭动等运动。其它关于电活性聚合物的信息可美国专利申请第2004/0008853号中找到,以引用方式并入本文。
另一方面,多个纤毛320和321包括例如电致伸缩材料,如压电材料或磁致伸缩材料。这些材料可通过应用电场或磁场来驱动,分别由例如带有纤毛的类支架系统100的内部或外部的动力来源来提供。一方面,动力来源可以在带有纤毛的类支架系统100的外部但在接受者的内部。例如包括但不局限于,声能可以来源于带有纤毛的类支架系统100的内部或来源于接受者体内安置带有纤毛的类支架系统100的部位。另一方面,动力来源可以在接受者的外部,例如动力可从接受者外部提供给带有纤毛的类支架系统100,包括直接或间接地动力驱动多个纤毛320和321。另一方面,动力来源还可以在带有纤毛的类支架系统100的内部。
另一方面,纤毛动作的控制可通过控制器施行,例如包括但不局限于位于数字微处理器中心的全部或部分包埋在带有纤毛的类支架系统100或动力类支架系统内的控制器。此类包埋的控制器可被询问或编程,使用声、线或光回路或通过电。磁或电磁信号的无线传送。此类控制器可通过带有纤毛的类支架系统100或动力类支架系统内的一个或多个传感器获得信息。此类控制器也可以程序化的方式不时的指导从位于带有纤毛的类支架系统100或动力类支架系统内的一个或多个容器或储藏室释放一种或多种物质,或者可以指导、监测或控制部分或全部带有纤毛的类支架系统100或动力类支架系统的一种或多种大规模动作。
动力带有纤毛的类支架系统100的能量供应包括,但不局限于,包括一种或多种可能包埋的一次或二次电池,经由为此目的而应用的体外磁场、电场、声场、总机械动作场(gross-mechanical-motion field)或光场的电池再充电或直接的动力传递,可能包埋在所述系统内的产生化学能的系统。一方面,能量可再充或再生。例如,通过体外或体内来源,以及包埋或植入有带有纤毛的类支架系统100或动力类支架系统的机体内一种或多种肌肉的动作产生的动能的转导/转换,例如包括但不局限于惯性-机械-电转导。
所述的带有纤毛的类支架系统100或动力类支架系统可包括:附加部件;集成部件;或在直径方向膨胀和/或收缩以及沿着局部管腔轴向平移的性能;所述系统的任何部分,包括其全部。这些可包括但不局限于机械部件,例如线性马达、电或磁致伸缩驱动器、牵引部件、气体驱动器、蠕动部件等。
带有纤毛的类支架系统100或带有动力的类支架系统可包括:附加部件;集成部件;或检测和/或定量测定(达到规定的准确度)其环境的一种或多种特征或变量的性能,将这些信息处理、储存并发送至体外接受器的性能,以及从一个或多个体外点(points)接收控制信息或询问信息的性能。
可由带有纤毛的类支架系统100储存和/或释放的物质形式包括但不局限于所有类型的液体、气体、乳液、凝胶、雾(mists)、喷雾、粉尘、粉末、所有类型的雾化或碳化粒子物质,及其组合物可以是一种或多种药物、药剂、治疗剂、生物活性剂、化学品、化合物、表面活性剂、类固醇、腔道膨胀剂、腔道收缩剂、抗生素或抗真菌或抗病毒剂、蛋白质、核酸或由一种或多种核酸组成的聚合物、大分子、或肽、照影剂或药理剂。
B.操作和/或方法
参考附图,并且当前参考附图7,是被植入气管701的带有纤毛的类支架系统100的简图。在另一个实施方案中,带有纤毛的类支架系统100被植入细支气管703或支气管702或支气管树的任意部分中。在其它的实施方案中,带有纤毛的类支架系统100不受限于肺部系统并且可使用于接受者任何管或器官的管腔中,例如,动物体内的任何管。
在一个实施方案中,带有纤毛的类支架系统100包括但不局限于用来操作带有纤毛的类支架系统100和/或多个纤毛320和321的外部控制器。带有纤毛的类支架系统100的操作可包括例如排除、移动、引导、定位或再定位所述的带有纤毛的类支架系统100。在一个实施例中,带有纤毛的类支架系统100可由医疗人员从远处进行控制或操作。在另一个实施例中,带有纤毛的类支架系统100可在接受者外部进行控制或操作。在另一个实施方案中,外部控制器可包括监控系统和/或操作带有纤毛的类支架系统100和/或多个纤毛320和321的无线回路。
在一个实施方案中,带有纤毛的类支架系统100包括移动或转移各种类型生物废物的系统或装置,所述生物废物如流体、粒子、流化态粒子、粘液、渗出液或生物碎片。例如,所述的装置或系统可包括与用于显示碎片区域的监测器相连的虹吸管。然后可见的碎片通过定位并操作虹吸管而被虹吸。在一个实施例中,所述的虹吸管可与多个纤毛320和321协作使用。在此实施例中,所述的多个纤毛320和321可用于收集和/或排除任何碎片,而所述虹吸管被用来将所述收集的或排除的任何碎片从肺部管道的一个或多个部位收集和/或转移入食管。
在一个实施方案中,带有纤毛的类支架系统100的用途包括但不局限于肺部疾病的治疗,例如慢性障碍性肺部疾病(COPD)。COPD包括以呼吸困难为表征的疾病或以例如慢性支气管炎、哮喘或肺气肿为表征的病症。其它的信息可在以下两篇文章中找到:PJ.Barnes,″Small Airways inCOPD.″New England Journal of Medicine,350:256,2635-2637页,2004年7月4日;和E.R.Sutherland,R.M.Cherniack,″Management of ChronicObstructive Pulmonary Disease,2689-2697页,2004年6月24日,以引用方式并入本文。在另一个实施方案中,带有纤毛的类支架系统100可以被配置来解决例如囊性纤维化疾病,在所述疾病中,粘膜纤毛系统的性能障碍导致粘液、渗出液和病原体在肺中的累积,引起延长的、有时致命的感染。在此实施例中,带有纤毛的类支架系统100可通过积极地排除例如流体、粒子、流化态粒子、粘液、渗出液或生物碎片来帮助清理气体通道,包括结合使用从所述带有纤毛的类支架系统100或其它来源所释放和/或分散的表面活性剂或粘度调节剂。
在一个实施方案中,多个纤毛320和321被设计来间歇地活动。在另一个实施方案中,多个纤毛320和321被设计来持续地活动。本领域技术人员应该理解多个纤毛320和321的运动可以根据许多标准来进行调节,所述标准例如使用区域或所要求执行任务的特点。
C.变化和/或实施方案
本领域技术人员应该理解,本申请教导了在本发明构思之内的装置、结构和/或方法的改进。例如,带有纤毛的类支架系统100不必局限于圆筒或管的形状。例如,带有纤毛的类支架系统100可具有复合的或多段的可变形状以提供最适合动物体内使用部位的形状。在另一个实施例中,带有纤毛的类支架系统100可具有基本上平面或圆锥的形状,或可随着其装入或横切入动物管道内腔而显著改变其形状。按照此处教导的,本领域技术人员应该理解对本发明主题的其他改进。
本领域技术人员应该理解带有纤毛的类支架系统100可由赋予其全部或部分可处理性的材料所制备。在一个实施例中,带有纤毛的类支架系统100的外表面312被设计来递送试剂或执行移动阻塞物和随后分解的功能。例如,带有纤毛的类支架系统100的外表面312可使用与管腔壁接触的试剂涂布。带有纤毛的类支架系统100的主体可被设计成在一定间隔的时间内分解或溶解,使试剂留在管腔上或管腔内。或者,带有纤毛的类支架系统100本身可以持续或在程序控制下释放一种或多种试剂于管腔中。任何的此类药剂可被再次装入带有纤毛的类支架系统100内的隔室或容器而得到补充。按照此处教导的,本领域技术人员将理解对本发明主题的其他改进。
本领域技术人员将理解带有纤毛的类支架系统100可包括从放置所述支架的接受者或动物外部控制其无线或机器人(robotic)附属部件。按照此处教导的,本领域技术人员将理解对本发明主题的其它改进。
先前描述的方面描述了包含在不同的其它组件内或与不同的其它组件相连的不同组件。应该理解此类描述的结构仅仅示例性的,并且事实上可以实施获得同样功能的许多其它结构。在概念意义上,任何获得同样功能的组件排列是有效“联合的”,以便获得所需的功能。因此,此处被组合以获得特定功能的任何两种组件可以被视为彼此“联合的”,以便在不考虑结构或中间组件时获得所需的功能。同样,如此联合的任何两种组件也可看作为彼此“操作连接的”或“操作偶合的”以获得所需的功能。
虽然本文描述的本发明主题的具体方面已被展示和描述,但对于本领域技术人员显而易见的是,基于本文的教导,可以在不脱离本文描述的本发明主题及其更广的方面下做出改变和改进,因此,权利要求书将属于本发明主题构思和范围之内的所有这类改变或改进包括在权利要求的范围之内。此外,应该理解本发明由权利要求书单独限定。本领域技术人员应该理解,通常,本文使用的术语以及特别是权利要求书中使用的术语(例如,权利要求书的主体)一般意欲作为“开放性”术语(例如,术语“包括(including)”应解释为“包括但不局限于”,术语“具有”应解释为“至少具有”,术语“包括(includes)”应解释为“包括但不局限于”,等)。本领域技术人员还将理解,如果引出的权利要求中叙述的特定数目是有意的,则此意图将在权利要求中明确地叙述,并且在此类叙述不存在时则不存在此意图。例如,作为理解的帮助,权利要求书可包含引导短语“至少一种”和“一种或多种”的使用以引出权利要求的叙述。然而,即使当相同的权利要求包括引导短语“一种或多种”或“至少一种”以及不定冠词例如“一”或“一”(例如,“一”和/或“一”一般应解释为“至少一种”或“一种或多种”的含义)时,对于仅含有这样一种叙述的发明,此类短语的使用不应理解为包含通过不定冠词“一”或“一”限定任何特定包含此类引入权利要求叙述的权利要求。其也适用于引入的权利要求叙述中定冠词的使用。此外,即使引入的权利要求叙述的特定数目明确地叙述,本领域技术人员将理解此类叙述应一般解释为表示至少叙述的数目(例如,“两种叙述”的无限定叙述,无其它修饰语时,一般表示至少两种叙述,或两种或多种叙述),等。

Claims (83)

1.一种装置,其包含:
一柔韧中空部分,其具有外表面和内表面,其中所述柔韧中空部分被裁定大小以放置在接受者体内的一个部位中;和
多个可活动部件,其连接至所述的柔韧中空部分内表面,所述的可活动部件可作为一组进行操作来移动颗粒。
2.如权利要求2所述的装置,其中所述的柔韧中空部分进一步包含:
基本上是管状或圆筒状的结构。
3.如权利要求2所述的装置,其中所述的基本上可膨胀的管状或圆筒状的结构进一步包含:
至少一个基本上可膨胀或收缩的结构。
4.如权利要求2所述的装置,其中所述的基本上可膨胀的管状或圆筒状的柔韧结构进一步包含:
可膨胀的网。
5.如权利要求2所述的装置,其中所述的基本上是管状或圆筒状的结构进一步包含:
连接至多个可活动部件的多个可膨胀的段。
6.如权利要求2所述的装置,其中所述的基本上是管状或圆筒状的结构包含:
一种或多种金属、硅、聚合物、塑料、有机物或可生物降解材料。
7.如权利要求2所述的装置,其中所述的基本上是管状或圆筒状的结构进一步包含:
一种或多种药物、药剂、治疗剂、生物活性剂、化学品、化合物、表面活性剂、类固醇、腔道膨胀剂、腔道收缩剂、抗生素或抗真菌或抗病毒剂、蛋白质、核酸或由一种或多种核酸组成的聚合物、大分子、肽、聚合物或可生物降解材料的涂层。
8.如权利要求1所述的装置,其中所述的柔韧中空部分进一步包含:
用于放置在特定部位的形状或结构。
9.如权利要求8所述的装置,其中所述的柔韧中空部分进一步包含:
用于放置在气管、支气管、支气管树、生殖泌尿道、胃肠道、肺部管道、神经脉管系统或脉管系统的形状或结构。
10.如权利要求8所述的装置,其中所述的柔韧中空部分进一步包含:
用于放置在接受者的器官或组织或其部分中穿过的管腔的形状或结构。
11.如权利要求1所述的装置,其中所述的柔韧中空部分进一步包含:
一个或多个柔韧中空部分,所述一个或多个柔韧中空部分连接组成可操作的条,所述可操作的条形成针对一个部位的结构。
12.如权利要求1所述的装置,其中所述的柔韧中空部分进一步包含:
一个或多个分叉或分枝。
13.如权利要求1所述的装置,其中所述的柔韧中空部分进一步包含:
基本上光滑的内表面。
14.如权利要求1所述的装置,其中所述的柔韧中空部分包含:
具有低摩擦系数的、可操作用于空气或流体低阻力流动的内表面。
15.如权利要求1所述的装置,其中所述的柔韧中空部分包含:
具有表面改性的、可操作用于粘附、粘着或定位于接受者特定部位的外表面。
16.如权利要求1所述的装置,其中所述的接受者包括:
动物或植物。
17.如权利要求13所述的装置,其中所述的表面改性包含:
一个或多个沟、凸起、脊、环或回路。
18.如权利要求1所述的装置,其中所述的多个可活动部件进一步包含:
一个或多个凝胶、水凝胶、胶质、聚合物、振荡聚合物、电活性聚合物、聚合物、电或磁致伸缩材料、线性马达部件或使用生物相容性材料涂布的物质。
19.如权利要求1所述的装置,其中所述的多个可活动部件进一步包含:
用于移动流体、颗粒、流化态粒子、粘液、渗出液或碎片的低水平步态或动作。
20.如权利要求1所述的装置,其中所述的多个可活动部件进一步包含:
用于移动流体、颗粒、流化态粒子、粘液、渗出液、或碎片的高水平步态或动作。
21.如权利要求1所述的装置,其中所述的装置进一步包含:
驱动器、马达、生物分子马达或可操作用于提供与所述多个可活动部件连接的动作的部件。
22.如权利要求1所述的装置,其中所述的装置进一步包含:
用于控制所述多个可活动部件或所述柔韧中空部分的电场、磁场、声场、光场或电磁场。
23.如权利要求1所述的装置,其中所述的装置进一步包含:
用于控制所述装置的外部或内部的电场、磁场、声场、光场或电磁场。
24.如权利要求1所述的装置,其中所述的装置包含:
用于代替或功能性补充至少一部分气管、支气管、支气管树、生殖泌尿道、胃肠道、肺部管道、神经脉管系统或脉管系统的定制的大小、形状或尺寸。
25.如权利要求1所述的装置,其中所述的装置进一步包含:
用于监测、操作或控制所述装置的与所述装置连接的外部控制器。
26.如权利要求1所述的装置,其中所述的装置进一步包含:
连接至所述外部控制器的监测器。
27.如权利要求1所述的装置,其中所述的装置进一步包含:
连接至所述装置用以操作所述装置的遥控系统。
28.如权利要求1所述的装置,其中所述的装置进一步包含:
连接至所述装置的排泄部件。
29.如权利要求1所述的装置,其中所述的装置进一步包含:
用于分散至少一种药物、药剂、治疗剂、生物活性剂、化学品、化合物、表面活性剂、类固醇、腔道膨胀剂、腔道收缩剂、抗生素或抗真菌或抗病毒剂、蛋白质、核酸或由一种或多种核酸组成的聚合物、大分子、肽、聚合物或可生物降解材料的机械部件。
30.如权利要求1所述的装置,其中所述的装置进一步包含:
用于储存一种或多种药物、药剂、治疗剂、生物活性剂、化学品、化合物、表面活性剂、类固醇、腔道膨胀剂、腔道收缩剂、抗生素或抗真菌或抗病毒剂、蛋白质、核酸或由一种或多种核酸组成的聚合物、大分子、肽、聚合物或可生物降解材料的容器。
31.如权利要求1所述的装置,其中所述的柔韧中空部分进一步包含:
一个或多个连接至所述柔韧中空部分外表面的可活动部件。
32.如权利要求1所述的装置,其中所述的装置进一步包含:
为所述装置提供动力的机械部件。
33.如权利要求32所述的装置,其中所述为所述装置提供动力的机械装置进一步包含:
用于获得或储存能量的机械部件。
34.一种制备装置的方法,其包含:
制成可植入接受者体内的支撑通道;
将多个可活动部件连接至所述支撑通道;并
裁定所述支撑通道和与所述支撑通道相连的多个可活动部件的大小以放入所述接受者的一个部位中。
35.如权利要求34所述的方法,其中所述的方法进一步包含:
将所述多个可活动部件连接至所述支撑通道以移动一种或多种流体、颗粒、流化态粒子、物体、碎片、粘液、渗出液或碎片。
36.如权利要求34所述的方法,其中所述的方法进一步包含:
形成所述支撑通道,其中至少有一部分支撑通道是至少基本上柔韧、可压缩或膨胀的。
37.如权利要求34所述的方法,其中所述的方法进一步包含:
形成所述支撑通道,其包括与所述多个可活动部件连接的基本上可膨胀的管状或圆筒状部件。
38.如权利要求34所述的方法,其中所述的方法进一步包含:
形成所述支撑通道,其包括与所述多个可活动部件连接的可膨胀网。
39.如权利要求34所述的方法,其中所述的方法进一步包含:
形成所述支撑通道,其连接于形成用于放入接受者体内特定部位的结构的所述多个可活动部件。
40.如权利要求34所述的方法,其中所述的方法进一步包含:
形成分两叉的支撑通道。
41.如权利要求34所述的方法,其中所述的方法进一步包含:
形成所述支撑通道或多个可活动部件,其是使用一种或多种金属、硅、聚合物、塑料、无机物、有机物或可生物降解材料制成的。
42.如权利要求34所述的方法,其中所述的方法进一步包含:
所述支撑通道或所述多个可活动部件的至少一部分使用生物相容性材料、聚合物、可生物降解材料、药物、药剂或治疗剂进行涂布。
43.如权利要求34所述的方法,其中所述的方法进一步包含:
在所述支撑通道的至少一部分的内部制成光滑表面。
44.如权利要求34所述的方法,其中所述的方法进一步包含:
在所述支撑通道的外部制成可操作用以粘附或定位于动物体内大致的特定部位的表面改性。
45.如权利要求44所述的方法,其中所述的方法进一步包含:
形成表面改性,其包括在支撑通道外的沟、回路、脊、环或突起。
46.如权利要求34所述的方法,其中所述的方法进一步包含:
形成所述支撑通道或所述多个可活动部件,其包括一种或多种凝胶、水凝胶、胶质、聚合物、振荡聚合物、电活性聚合物、聚合物或使用生物相容材料涂布的材料。
47.如权利要求34所述的方法,其中所述的方法进一步包含:
定向所述多个可活动部件为向外放射状。
48.如权利要求34所述的方法,其中所述的方法进一步包含:
设定所述多个可活动部件的结构来限定低水平的步态或动作。
49.如权利要求34所述的方法,其中所述的方法进一步包含:
设定所述多个可活动部件的结构来限定高水平的步态或动作。
50.如权利要求34所述的方法,其中所述的方法进一步包含:
将所述多个可活动部件中包括至少一个能实现向上、向下、循环、旋转、直线、平移、或水平运动的部件。
51.如权利要求34所述的方法,其中所述的方法进一步包含:
包括具有独立的、相继的、或同步的动作的多个可活动部件。
52.如权利要求34所述的方法,其中所述的方法进一步包含:
将驱动器、马达、生物分子马达或可操作用以提供动作的部件操作连接至所述的多个可活动部件。
53.如权利要求34所述的方法,其中所述的方法进一步包含:
在所述的多个部件或可操作来控制所述一个或多个可活动部件的动作或方向的驱动器中包括内部的电场、磁场或机械应力场。
54.如权利要求34所述的方法,其中所述的方法进一步包含:
包括用于控制或指导所述多个可活动部件的电场、磁场、声场、光场或电磁场。
55.如权利要求34所述的方法,其中所述的方法进一步包含:
用于控制或指导所述多个可活动部件的外部或内部的电场、磁场、声场、光场或电磁场。
56.如权利要求34所述的方法,其中所述的方法包含:
形成所述支撑通道,其具有用于放入气管、支气管、支气管树、生殖泌尿道、胃肠道、肺部管道、神经脉管系统或脉管系统中的定制的大小、形状、结构或尺寸。
57.如权利要求34所述的方法,其中所述的方法包含:
形成所述支撑通道,其具有用于代替或功能性补充至少一部分气管、支气管、支气管树、生殖泌尿道、胃肠道、肺部管道、神经脉管系统或脉管系统的定制的大小、形状、结构或尺寸。
58.如权利要求34所述的方法,其中所述的方法进一步包含:
将外部控制系统连接至所述的多个可活动部件或所述的支撑通道。
59.如权利要求34所述的方法,其中所述的方法进一步包含:
包括用于远程操作或操纵所述装置的外部控制系统。
60.如权利要求34所述的方法,其中所述的方法进一步包含:
将监测器连接至所述的支撑通道。
61.如权利要求34所述的方法,其中所述的方法进一步包含:
将碎片清除、碎片替换或碎片转移系统连接至所述的支撑通道。
62.如权利要求34所述的方法,其中所述的方法进一步包含:
提供用于储存至少一种药物、药剂、治疗剂、生物活性剂、化学品、化合物、表面活性剂、类固醇、腔道膨胀剂、腔道收缩剂、抗生素或抗真菌或抗病毒剂、蛋白质、核酸或由一种或多种核酸组成的聚合物、大分子、肽、聚合物或可生物降解材料的储存系统。
63.如权利要求34所述的方法,其中所述的方法进一步包含:
使用至少一种药物、药剂、治疗剂、生物活性剂、化学品、化合物、表面活性剂、类固醇、腔道膨胀剂、腔道收缩剂、抗生素或抗真菌或抗病毒剂、蛋白质、核酸或由一种或多种核酸组成的聚合物、大分子、肽、聚合物或可生物降解材料将所述装置的至少一部分进行涂布。
64.如权利要求34所述的方法,其中所述的方法进一步包含:
包括用于释放一种或多种药物、药剂、治疗剂、生物活性剂、化学品、化合物、表面活性剂、类固醇、腔道膨胀剂、腔道收缩剂、抗生素或抗真菌或抗病毒剂、蛋白质、核酸或由一种或多种核酸组成的聚合物、大分子、肽、聚合物或可生物降解材料的机械部件。
65.如权利要求34所述的方法,其中所述的方法进一步包含:
在所述装置的内部或外部储存能量。
66.如权利要求34所述的方法,其中所述的方法进一步包含:
提供一种用于获得动力的机械部件。
67.如权利要求34所述的方法,其中所述的方法进一步包含:
将所述的多个可活动部件连接至所述的支撑通道的至少一个内壁或外壁。
68.一种方法,其包含:
将中空可膨胀部件放入接受者的腔内部分,其中所述的中空可膨胀部件的内部与一个或多个活动条相连;将所述的中空可膨胀部件定位在器官的管腔中;并监控所述的中空可膨胀部件。
69.如权利要求68所述的方法,其中所述的方法进一步包含:
调节、指导、定位、引导或驱动所述的中空可膨胀部件。
70.如权利要求68所述的方法,其中所述的方法进一步包含:
移去所述的中空可膨胀部件。
71.如权利要求68所述的方法,其中所述的方法进一步包含:
驱动所述的一个或多个连接至所述中空可膨胀部件的活动条以移动流体、颗粒、流化态粒子、粘液、渗出液或碎片。
72.如权利要求68所述的方法,其中所述的方法包含:
提供用于形成所述中空可膨胀部件的大小、尺寸、或定制的改性。
73.如权利要求68所述的方法,其中所述的方法进一步包含:
应用至少一种外部的电场、磁场、声场、光场或电磁场以清除流体、颗粒、流化态粒子、粘液、渗出液或碎片。
74.如权利要求68所述的方法,其中所述的方法进一步包含:
将所述的中空可膨胀部件放入气管、支气管、支气管树、生殖泌尿道、胃肠道、肺部管道、神经脉管系统或脉管系统中。
75.如权利要求68所述的方法,其中所述的方法进一步包含:控制所述多个活动条的动作或方向。
76.如权利要求68所述的方法,其中所述的方法进一步包含:调节所述多个活动条的定向。
77.如权利要求68所述的方法,其中所述的方法进一步包含:
放置所述的中空可膨胀部件,其中所述的中空可膨胀部件具有至少一个分叉。
78.如权利要求68所述的方法,其中所述的方法进一步包含:定位所述至少一个分叉。
79.如权利要求68所述的方法,其中所述的方法进一步包含:清除任何碎片。
80.如权利要求68所述的方法,其中所述的方法进一步包含:远程监控所述的中空可膨胀部件。
81.如权利要求68所述的方法,其中所述的方法进一步包含:远程定位所述的中空可膨胀部件和多个可活动部件。
82.如权利要求68所述的方法,其中所述的方法进一步包含:将所述的中空可膨胀部件装料。
83.如权利要求68所述的方法,其中所述的方法进一步包含:
递送药物、药剂、治疗剂、生物活性剂、化学品、化合物、表面活性剂、类固醇、腔道膨胀剂、腔道收缩剂、抗生素或抗真菌或抗病毒剂、蛋白质、核酸或由一种或多种核酸组成的聚合物、大分子、肽、聚合物或可生物降解材料。
CNA2005800401468A 2004-09-24 2005-09-19 一种带纤毛的类支架系统 Pending CN101065077A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/949,186 US8092549B2 (en) 2004-09-24 2004-09-24 Ciliated stent-like-system
US10/949,186 2004-09-24

Publications (1)

Publication Number Publication Date
CN101065077A true CN101065077A (zh) 2007-10-31

Family

ID=36100283

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800401468A Pending CN101065077A (zh) 2004-09-24 2005-09-19 一种带纤毛的类支架系统

Country Status (7)

Country Link
US (1) US8092549B2 (zh)
JP (1) JP2008514284A (zh)
KR (1) KR101255377B1 (zh)
CN (1) CN101065077A (zh)
DE (1) DE112005002338T5 (zh)
GB (1) GB2432537B (zh)
WO (1) WO2006036633A2 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101133246B (zh) * 2005-02-21 2012-01-11 皇家飞利浦电子股份有限公司 基于致动器元件的微流体系统
CN102370476A (zh) * 2011-09-28 2012-03-14 上海交通大学 心血管血液流速传感器
CN103826694A (zh) * 2011-09-30 2014-05-28 柯惠有限合伙公司 能量传递装置以及使用方法

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7998060B2 (en) * 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US8361013B2 (en) * 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US8337482B2 (en) * 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US8353896B2 (en) * 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
CN101247758B (zh) * 2005-05-11 2014-07-02 明尼苏达大学评议会 利用磁感应进行成像的方法和设备
US8764697B2 (en) 2006-02-01 2014-07-01 Agathos Holdings Llc Systems and methods for an advanced medical device
US8096967B2 (en) * 2006-02-02 2012-01-17 Milan Radojicic Tissue engineered cerebrospinal fluid shunt
US20090165877A1 (en) * 2006-02-07 2009-07-02 Koninklijke Philips Electronics N.V. Actuator elements for microfluidics, responsive to multiple stimuli
US20080058785A1 (en) * 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US20080058786A1 (en) * 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
EP2052154A2 (en) * 2006-07-17 2009-04-29 Koninklijke Philips Electronics N.V. Micro-fluidic system
CN100428919C (zh) * 2006-07-31 2008-10-29 中南大学湘雅二医院 一种人工气管
US20080033522A1 (en) * 2006-08-03 2008-02-07 Med Institute, Inc. Implantable Medical Device with Particulate Coating
JP2010500182A (ja) * 2006-08-09 2010-01-07 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マイクロ流体システム
US9242073B2 (en) * 2006-08-18 2016-01-26 Boston Scientific Scimed, Inc. Electrically actuated annelid
EP2114628A2 (en) * 2006-11-28 2009-11-11 University of Tartu A shape changing manipulator comprising self-sensing actuators made of an electroactive polymer material
WO2008125927A2 (en) * 2006-12-19 2008-10-23 Koninklijke Philips Electronics N.V. Microfluidic system with actuators
US7655004B2 (en) 2007-02-15 2010-02-02 Ethicon Endo-Surgery, Inc. Electroporation ablation apparatus, system, and method
EP1970122A1 (en) * 2007-03-12 2008-09-17 Koninklijke Philips Electronics N.V. Microfluidic system based on magnetic actuator elements
EP1992410A1 (en) * 2007-03-12 2008-11-19 Stichting Dutch Polymer Institute Microfluidic system based on actuator elements
WO2008132651A1 (en) * 2007-04-26 2008-11-06 Koninklijke Philips Electronics N.V. Micromixer and/or microreactor with active flow controlling means
WO2008139378A1 (en) * 2007-05-11 2008-11-20 Koninklijke Philips Electronics N.V. Pulse driving of actuator elements for fluid actuation
US8262655B2 (en) 2007-11-21 2012-09-11 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8579897B2 (en) * 2007-11-21 2013-11-12 Ethicon Endo-Surgery, Inc. Bipolar forceps
US8568410B2 (en) 2007-08-31 2013-10-29 Ethicon Endo-Surgery, Inc. Electrical ablation surgical instruments
US20090112059A1 (en) 2007-10-31 2009-04-30 Nobis Rudolph H Apparatus and methods for closing a gastrotomy
US8480657B2 (en) * 2007-10-31 2013-07-09 Ethicon Endo-Surgery, Inc. Detachable distal overtube section and methods for forming a sealable opening in the wall of an organ
US20090163856A1 (en) * 2007-12-19 2009-06-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Treatment indications informed by a prior implant information
US9717896B2 (en) * 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US8636670B2 (en) * 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US20090292214A1 (en) * 2008-05-22 2009-11-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20100036263A1 (en) * 2008-08-07 2010-02-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US20090292213A1 (en) * 2008-05-21 2009-11-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
US8262680B2 (en) * 2008-03-10 2012-09-11 Ethicon Endo-Surgery, Inc. Anastomotic device
US8771260B2 (en) 2008-05-30 2014-07-08 Ethicon Endo-Surgery, Inc. Actuating and articulating surgical device
US8679003B2 (en) 2008-05-30 2014-03-25 Ethicon Endo-Surgery, Inc. Surgical device and endoscope including same
US8403926B2 (en) 2008-06-05 2013-03-26 Ethicon Endo-Surgery, Inc. Manually articulating devices
US8361112B2 (en) 2008-06-27 2013-01-29 Ethicon Endo-Surgery, Inc. Surgical suture arrangement
US20100010294A1 (en) * 2008-07-10 2010-01-14 Ethicon Endo-Surgery, Inc. Temporarily positionable medical devices
US8888792B2 (en) 2008-07-14 2014-11-18 Ethicon Endo-Surgery, Inc. Tissue apposition clip application devices and methods
US8262563B2 (en) 2008-07-14 2012-09-11 Ethicon Endo-Surgery, Inc. Endoscopic translumenal articulatable steerable overtube
US8211125B2 (en) * 2008-08-15 2012-07-03 Ethicon Endo-Surgery, Inc. Sterile appliance delivery device for endoscopic procedures
US20100145511A1 (en) * 2008-08-18 2010-06-10 Popa Dan O Microcrawler and conveyor robots, controllers, systems, and methods
US8529563B2 (en) * 2008-08-25 2013-09-10 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8241204B2 (en) 2008-08-29 2012-08-14 Ethicon Endo-Surgery, Inc. Articulating end cap
US8480689B2 (en) * 2008-09-02 2013-07-09 Ethicon Endo-Surgery, Inc. Suturing device
US8409200B2 (en) 2008-09-03 2013-04-02 Ethicon Endo-Surgery, Inc. Surgical grasping device
US8337394B2 (en) 2008-10-01 2012-12-25 Ethicon Endo-Surgery, Inc. Overtube with expandable tip
US8778666B1 (en) * 2008-10-27 2014-07-15 University Of Washington Devices, apparatus, and methods employing biomimetic cilia for microfluidic manipulation
KR101003149B1 (ko) * 2008-10-31 2010-12-22 전남대학교산학협력단 병변 치료용 박테리아 기반의 마이크로로봇
US8157834B2 (en) 2008-11-25 2012-04-17 Ethicon Endo-Surgery, Inc. Rotational coupling device for surgical instrument with flexible actuators
JP2010145649A (ja) * 2008-12-17 2010-07-01 Olympus Corp ガイドチューブ、ガイドチューブ装置および内視鏡システム
JP5389429B2 (ja) * 2008-12-17 2014-01-15 オリンパス株式会社 ガイドチューブ、ガイドチューブ装置および内視鏡システム
US8361066B2 (en) 2009-01-12 2013-01-29 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US9226772B2 (en) * 2009-01-30 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical device
US8252057B2 (en) 2009-01-30 2012-08-28 Ethicon Endo-Surgery, Inc. Surgical access device
FR2944201B1 (fr) * 2009-04-14 2011-06-10 Novatech Sa Obturateur bronchique a valve
US20110098704A1 (en) 2009-10-28 2011-04-28 Ethicon Endo-Surgery, Inc. Electrical ablation devices
US8608652B2 (en) * 2009-11-05 2013-12-17 Ethicon Endo-Surgery, Inc. Vaginal entry surgical devices, kit, system, and method
US8353487B2 (en) * 2009-12-17 2013-01-15 Ethicon Endo-Surgery, Inc. User interface support devices for endoscopic surgical instruments
US8496574B2 (en) 2009-12-17 2013-07-30 Ethicon Endo-Surgery, Inc. Selectively positionable camera for surgical guide tube assembly
US9028483B2 (en) 2009-12-18 2015-05-12 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US8506564B2 (en) 2009-12-18 2013-08-13 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US9005198B2 (en) * 2010-01-29 2015-04-14 Ethicon Endo-Surgery, Inc. Surgical instrument comprising an electrode
US8709093B2 (en) * 2010-08-09 2014-04-29 Boston Scientific Scimed, Inc. Tracheal stent with longitudinal ribs to minimize stent movement, coughing and halitosis
US10092291B2 (en) 2011-01-25 2018-10-09 Ethicon Endo-Surgery, Inc. Surgical instrument with selectively rigidizable features
US9254169B2 (en) 2011-02-28 2016-02-09 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9314620B2 (en) 2011-02-28 2016-04-19 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9233241B2 (en) 2011-02-28 2016-01-12 Ethicon Endo-Surgery, Inc. Electrical ablation devices and methods
US9049987B2 (en) 2011-03-17 2015-06-09 Ethicon Endo-Surgery, Inc. Hand held surgical device for manipulating an internal magnet assembly within a patient
WO2014023997A2 (en) * 2012-05-11 2014-02-13 Weber Eric Robert Biomimetic artificial secured airway
US20130142835A1 (en) * 2011-07-06 2013-06-06 Alexander M. Seifalian Synthetic scaffolds and organ and tissue transplantation
US11389638B2 (en) * 2012-02-07 2022-07-19 Hridaya, Inc. Hemodynamic assist device
CN104185481B (zh) 2012-02-07 2017-02-22 赫莱达雅公司 血液动力学辅助设备
US8986199B2 (en) 2012-02-17 2015-03-24 Ethicon Endo-Surgery, Inc. Apparatus and methods for cleaning the lens of an endoscope
EP4052680A1 (en) 2012-04-06 2022-09-07 Boston Scientific Scimed, Inc. Anti-migration micropatterned stent coating
US9526640B2 (en) 2013-08-18 2016-12-27 Boston Scientific Scimed, Inc. Anti-migration micropatterned stent coating
US9427255B2 (en) 2012-05-14 2016-08-30 Ethicon Endo-Surgery, Inc. Apparatus for introducing a steerable camera assembly into a patient
US9078662B2 (en) 2012-07-03 2015-07-14 Ethicon Endo-Surgery, Inc. Endoscopic cap electrode and method for using the same
US9545290B2 (en) 2012-07-30 2017-01-17 Ethicon Endo-Surgery, Inc. Needle probe guide
US9572623B2 (en) 2012-08-02 2017-02-21 Ethicon Endo-Surgery, Inc. Reusable electrode and disposable sheath
US10314649B2 (en) 2012-08-02 2019-06-11 Ethicon Endo-Surgery, Inc. Flexible expandable electrode and method of intraluminal delivery of pulsed power
US9353313B2 (en) 2012-08-09 2016-05-31 Auburn University Microdevices and methods of manufacture
US9277957B2 (en) 2012-08-15 2016-03-08 Ethicon Endo-Surgery, Inc. Electrosurgical devices and methods
ES2654189T3 (es) 2012-09-12 2018-02-12 Boston Scientific Scimed, Inc. Revestimiento adhesivo anti-migración para stent
US10098527B2 (en) 2013-02-27 2018-10-16 Ethidcon Endo-Surgery, Inc. System for performing a minimally invasive surgical procedure
CA2882364C (en) 2013-03-15 2017-01-03 Boston Scientific Scimed, Inc. Anti-migration micropatterned stent coating
EP3427766B1 (en) 2013-08-08 2020-09-23 Boston Scientific Scimed, Inc. Dissolvable or degradable adhesive polymer to prevent stent migration
US9642944B2 (en) 2014-03-17 2017-05-09 Boston Scientific Scimed, Inc. Platelet-activated bioadhesive stent coating as an antimigration mechanism
US20150273156A1 (en) * 2014-03-26 2015-10-01 Boston Scientific Scimed, Inc. Devices for systemic drug delivery and related methods of use
CN106456344B (zh) 2014-04-02 2018-12-04 波士顿科学国际有限公司 使用粘附元件覆盖的内镜支架
KR101530828B1 (ko) * 2014-09-23 2015-06-24 윤성원 혈전제거 및 혈류 재개통용 혈관내 기구
WO2016073597A1 (en) 2014-11-06 2016-05-12 Boston Scientific Scimed, Inc. Tracheal stent
WO2016081709A1 (en) * 2014-11-20 2016-05-26 Boston Scientific Scimed, Inc. Tracheal implant
US20170014247A1 (en) * 2015-07-15 2017-01-19 Cook Medical Technologies Llc Stent Anti-Migration Mechanism
US9592138B1 (en) 2015-09-13 2017-03-14 Martin Mayse Pulmonary airflow
JP7145757B2 (ja) * 2015-10-12 2022-10-03 リフロー メディカル インコーポレイテッド 突出する薬剤送達フィーチャーを有するステント、ならびに、関連のシステムおよび方法
IT201700033787A1 (it) * 2017-03-28 2018-09-28 Alessandra Stracuzzi Dispositivo impiantabile in corrispondenza di un condotto biologico
JP7053799B2 (ja) * 2017-08-29 2022-04-12 シー・アール・バード・インコーポレーテッド 再構成可能なステントならびにシステムおよびその使用方法
US11723579B2 (en) 2017-09-19 2023-08-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US11273283B2 (en) 2017-12-31 2022-03-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
WO2020013209A1 (ja) * 2018-07-13 2020-01-16 隆夫 糸井 ステント
WO2020056418A1 (en) 2018-09-14 2020-03-19 Neuroenhancement Lab, LLC System and method of improving sleep

Family Cites Families (398)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391697A (en) * 1965-09-20 1968-07-09 Medtronic Inc Runaway inhibited pacemaker
US3837339A (en) 1972-02-03 1974-09-24 Whittaker Corp Blood glucose level monitoring-alarm system and method therefor
US3821469A (en) 1972-05-15 1974-06-28 Amperex Electronic Corp Graphical data device
US4119900A (en) 1973-12-21 1978-10-10 Ito Patent-Ag Method and system for the automatic orientation and control of a robot
US3941127A (en) 1974-10-03 1976-03-02 Froning Edward C Apparatus and method for stereotaxic lateral extradural disc puncture
US3983474A (en) 1975-02-21 1976-09-28 Polhemus Navigation Sciences, Inc. Tracking and determining orientation of object using coordinate transformation means, system and process
US4054881A (en) 1976-04-26 1977-10-18 The Austin Company Remote object position locater
DE2718804C3 (de) 1977-04-27 1979-10-31 Karlheinz Prof. Dr. 3000 Hannover Renner Vorrichtung zur PositionierungskontroUe von Patienten und/oder Bestrahlungsquellen
DE7805301U1 (de) 1978-02-22 1978-07-06 Howmedica International, Inc. Zweigniederlassung Kiel, 2300 Kiel Distales Zielgerät für die Verriegeliingsnagelung
US4202349A (en) 1978-04-24 1980-05-13 Jones James W Radiopaque vessel markers
FR2458838A1 (fr) 1979-06-06 1981-01-02 Thomson Csf Dispositif de mesure de l'orientation relative de deux corps et systeme de reperage de direction correspondant
US4314251A (en) 1979-07-30 1982-02-02 The Austin Company Remote object position and orientation locater
US4267831A (en) * 1979-09-24 1981-05-19 Aguilar Rogelio M Nasal air filter and medicament dispenser device
US4317078A (en) 1979-10-15 1982-02-23 Ohio State University Research Foundation Remote position and orientation detection employing magnetic flux linkage
DE3022497A1 (de) 1980-06-14 1981-12-24 Philips Patentverwaltung Gmbh, 2000 Hamburg Koppelfeld
US4339953A (en) 1980-08-29 1982-07-20 Aisin Seiki Company, Ltd. Position sensor
US4638798A (en) 1980-09-10 1987-01-27 Shelden C Hunter Stereotactic method and apparatus for locating and treating or removing lesions
US4367741A (en) 1980-12-22 1983-01-11 Alza Corporation Dispenser powered by cross-linked hydrophilic polymer grafted to hydrophilic polymer
US4431005A (en) 1981-05-07 1984-02-14 Mccormick Laboratories, Inc. Method of and apparatus for determining very accurately the position of a device inside biological tissue
US4583190A (en) * 1982-04-21 1986-04-15 Neuroscience, Inc. Microcomputer based system for performing fast Fourier transforms
US4628928A (en) 1982-08-09 1986-12-16 Medtronic, Inc. Robotic implantable medical device and/or component restoration system
US4771772A (en) 1982-08-09 1988-09-20 Medtronic, Inc. Robotic implantable medical device and/or component restoration system
US4658214A (en) 1982-12-28 1987-04-14 Polaroid Corporation Magnetic position indicator using multiple probes
US4651732A (en) 1983-03-17 1987-03-24 Frederick Philip R Three-dimensional light guidance system for invasive procedures
US4714460A (en) 1983-07-29 1987-12-22 Reynaldo Calderon Methods and systems for retrograde perfusion in the body for curing it of the disease or immume deficiency
US4800898A (en) * 1983-10-07 1989-01-31 Cordis Corporation Neural stimulator electrode element and lead
US6221102B1 (en) * 1983-12-09 2001-04-24 Endovascular Technologies, Inc. Intraluminal grafting system
US4642786A (en) 1984-05-25 1987-02-10 Position Orientation Systems, Ltd. Method and apparatus for position and orientation measurement using a magnetic field and retransmission
US4889526A (en) 1984-08-27 1989-12-26 Magtech Laboratories, Inc. Non-invasive method and apparatus for modulating brain signals through an external magnetic or electric field to reduce pain
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4585652A (en) * 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US4817601A (en) * 1985-03-06 1989-04-04 C. R. Bard, Inc. Catheter system for controlled removal by radiant energy of biological obstructions
US4769006A (en) 1985-05-13 1988-09-06 Kos Medical Technologies, Ltd. Hydrodynamically propelled pacing catheter
GR851148B (zh) * 1985-05-13 1985-05-22 Papantonakos Apostolos
US4805615A (en) 1985-07-02 1989-02-21 Carol Mark P Method and apparatus for performing stereotactic surgery
EP0239409A1 (en) 1986-03-28 1987-09-30 Life Technology Research Foundation Robot for surgical operation
US5078140A (en) 1986-05-08 1992-01-07 Kwoh Yik S Imaging device - aided robotic stereotaxis system
US5019372A (en) 1986-06-27 1991-05-28 The Children's Medical Center Corporation Magnetically modulated polymeric drug release system
US4763667A (en) 1986-09-19 1988-08-16 Microvasive, Inc. Tissue-penetrating catheter device
GB8701731D0 (en) 1987-01-27 1987-03-04 Patcentre Benelux Nv Sa Pumps
US4733661A (en) 1987-04-27 1988-03-29 Palestrant Aubrey M Guidance device for C.T. guided drainage and biopsy procedures
US4854315A (en) * 1987-06-25 1989-08-08 Stack Richard S Laser catheter
FR2624633B1 (fr) 1987-12-14 1992-09-11 Sgs Thomson Microelectronics Systeme de programmation d'un robot
US4962453A (en) 1989-02-07 1990-10-09 Transitions Research Corporation Autonomous vehicle for working on a surface and method of controlling same
US5153827A (en) 1989-01-30 1992-10-06 Omni-Flow, Inc. An infusion management and pumping system having an alarm handling system
US4994071A (en) * 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
US5051906A (en) 1989-06-07 1991-09-24 Transitions Research Corporation Mobile robot navigation employing retroreflective ceiling features
US5176638A (en) * 1990-01-12 1993-01-05 Don Michael T Anthony Regional perfusion catheter with improved drug delivery control
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5086401A (en) 1990-05-11 1992-02-04 International Business Machines Corporation Image-directed robotic system for precise robotic surgery including redundant consistency checking
US5204814A (en) 1990-11-13 1993-04-20 Mobot, Inc. Autonomous lawn mower
US5188111A (en) * 1991-01-18 1993-02-23 Catheter Research, Inc. Device for seeking an area of interest within a body
US5269303A (en) 1991-02-22 1993-12-14 Cyberonics, Inc. Treatment of dementia by nerve stimulation
US5165064A (en) 1991-03-22 1992-11-17 Cyberotics, Inc. Mobile robot guidance and navigation system
US5335657A (en) 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation
CA2042075C (en) 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5321614A (en) 1991-06-06 1994-06-14 Ashworth Guy T D Navigational control apparatus and method for autonomus vehicles
US5688269A (en) 1991-07-10 1997-11-18 Electroscope, Inc. Electrosurgical apparatus for laparoscopic and like procedures
US5234457A (en) 1991-10-09 1993-08-10 Boston Scientific Corporation Impregnated stent
US5366504A (en) * 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
WO1993009018A1 (en) 1991-11-05 1993-05-13 Seiko Epson Corporation Micro-robot
US5339051A (en) 1991-12-09 1994-08-16 Sandia Corporation Micro-machined resonator oscillator
US5313835A (en) 1991-12-19 1994-05-24 Motorola, Inc. Integrated monolithic gyroscopes/accelerometers with logic circuits
US5437660A (en) 1991-12-30 1995-08-01 Trimedyne, Inc. Tissue ablation and a lateral-lasing fiber optic device therefor
US6296638B1 (en) 1993-05-10 2001-10-02 Arthrocare Corporation Systems for tissue ablation and aspiration
US6963792B1 (en) 1992-01-21 2005-11-08 Sri International Surgical method
CA2087132A1 (en) * 1992-01-31 1993-08-01 Michael S. Williams Stent capable of attachment within a body lumen
US5502638A (en) 1992-02-10 1996-03-26 Honda Giken Kogyo Kabushiki Kaisha System for obstacle avoidance path planning for multiple-degree-of-freedom mechanism
US5599352A (en) 1992-03-19 1997-02-04 Medtronic, Inc. Method of making a drug eluting stent
WO1995014500A1 (en) * 1992-05-01 1995-06-01 Beth Israel Hospital A stent
US5310404A (en) * 1992-06-01 1994-05-10 Alza Corporation Iontophoretic delivery device and method of hydrating same
US5338625A (en) 1992-07-29 1994-08-16 Martin Marietta Energy Systems, Inc. Thin film battery and method for making same
EP0580928A1 (en) 1992-07-31 1994-02-02 ARIES S.r.l. A spinal electrode catheter
US5306294A (en) * 1992-08-05 1994-04-26 Ultrasonic Sensing And Monitoring Systems, Inc. Stent construction of rolled configuration
US5662587A (en) 1992-09-16 1997-09-02 Cedars Sinai Medical Center Robotic endoscopy
US5337732A (en) 1992-09-16 1994-08-16 Cedars-Sinai Medical Center Robotic endoscopy
DE4239987C2 (de) 1992-11-27 1996-07-11 Siemens Ag Selbstbewegliche Einheit zur Fortbewegung zwischen einander sich gegenüberliegenden Wandflächen
US5353807A (en) 1992-12-07 1994-10-11 Demarco Thomas J Magnetically guidable intubation device
US5314451A (en) 1993-01-15 1994-05-24 Medtronic, Inc. Replaceable battery for implantable medical device
US5381786A (en) 1993-02-11 1995-01-17 Wayne State University Method and apparatus for measurement of luminal dimensions
US5403311A (en) * 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
US5873835A (en) 1993-04-29 1999-02-23 Scimed Life Systems, Inc. Intravascular pressure and flow sensor
US5670329A (en) 1993-05-28 1997-09-23 Cardiovascular Diagnostics, Inc. Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field
US5728089A (en) 1993-06-04 1998-03-17 The Regents Of The University Of California Microfabricated structure to be used in surgery
AU6953994A (en) 1993-06-04 1995-01-03 Regents Of The University Of California, The Microfabricated acoustic source and receiver
US5386741A (en) 1993-06-07 1995-02-07 Rennex; Brian G. Robotic snake
DE4319812C1 (de) * 1993-06-15 1995-02-09 Zurbruegg Heinz R Implantierbare Ultraschallsonde zum Messen der Fließgeschwindigkeit des Blutes bei Menschen und Tieren
US5497147A (en) 1993-06-21 1996-03-05 Microstrain, Company Differential variable reluctance transducer
DE69432148T2 (de) 1993-07-01 2003-10-16 Boston Scient Ltd Katheter zur bilddarstellung, zur anzeige elektrischer signale und zur ablation
US5921982A (en) 1993-07-30 1999-07-13 Lesh; Michael D. Systems and methods for ablating body tissue
US5807395A (en) 1993-08-27 1998-09-15 Medtronic, Inc. Method and apparatus for RF ablation and hyperthermia
US5398670A (en) * 1993-08-31 1995-03-21 Ethicon, Inc. Lumen traversing device
US5476450A (en) 1993-11-04 1995-12-19 Ruggio; Joseph M. Apparatus and method for aspirating intravascular, pulmonary and cardiac obstructions
CA2180844A1 (en) 1994-01-13 1995-07-20 W. Clark Still Synthetic receptors, libraries and uses thereof
US6797522B1 (en) 1994-01-13 2004-09-28 The Trustees Of Columbia University In The City Of New York Synthetic receptors
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
DE4408982C1 (de) 1994-03-16 1995-05-18 Deutsche Forsch Luft Raumfahrt Autonomes Navigationssystem für einen mobilen Roboter oder Manipulator
CA2145232A1 (en) 1994-03-24 1995-09-25 Arie Avny Viewing method and apparatus particularly useful for viewing the interior of the large intestine
US5590660A (en) 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
DE69536046D1 (de) 1994-07-08 2010-04-01 Ev3 Inc System zum Durchführen eines intravaskulären Verfahrens
US5695457A (en) 1994-07-28 1997-12-09 Heartport, Inc. Cardioplegia catheter system
US5908027A (en) * 1994-08-22 1999-06-01 Alaris Medical Systems, Inc. Tonometry system for monitoring blood pressure
DE69533227T2 (de) 1994-10-28 2005-07-07 Advanced Medical Solutions Ltd., Winsford Rehydrierte hydrogele
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
US5835684A (en) 1994-11-09 1998-11-10 Amada Company, Ltd. Method for planning/controlling robot motion
US5643296A (en) 1994-12-16 1997-07-01 Devices For Vasclar Intervention Intravascular catheter with guiding structure
US5632754A (en) * 1994-12-23 1997-05-27 Devices For Vascular Intervention Universal catheter with interchangeable work element
US7027134B1 (en) 1995-02-08 2006-04-11 University Of South Florida Spectrophotometric system and method for the identification and characterization of a particle in a bodily fluid
US5589932A (en) 1995-02-08 1996-12-31 University Of South Florida Spectrophotometric method and apparatus for the characterization of blood and blood types
US5964773A (en) 1995-02-15 1999-10-12 Automated Medical Products, Inc. Laparascopic suturing device and suture needles
US5643246A (en) 1995-02-24 1997-07-01 Gel Sciences, Inc. Electromagnetically triggered, responsive gel based drug delivery device
US5735276A (en) * 1995-03-21 1998-04-07 Lemelson; Jerome Method and apparatus for scanning and evaluating matter
US6575969B1 (en) * 1995-05-04 2003-06-10 Sherwood Services Ag Cool-tip radiofrequency thermosurgery electrode system for tumor ablation
US5599324A (en) * 1995-05-04 1997-02-04 Boston Scientific Corporation Catheter for administering a liquid agent
IL113913A (en) 1995-05-30 2000-02-29 Friendly Machines Ltd Navigation method and system
US6255361B1 (en) 1995-11-21 2001-07-03 Acushnet Company Golf ball compositions and method of making same
JP3819032B2 (ja) * 1995-08-24 2006-09-06 ザ・テキサス・エイ・アンド・エム・ユニバーシティ・システム 組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析
DK2111876T3 (da) * 1995-12-18 2011-12-12 Angiodevice Internat Gmbh Tværbundne polymerpræparater og fremgangsmåder til anvendelse deraf
US5683432A (en) 1996-01-11 1997-11-04 Medtronic, Inc. Adaptive, performance-optimizing communication system for communicating with an implanted medical device
US6475639B2 (en) 1996-01-18 2002-11-05 Mohsen Shahinpoor Ionic polymer sensors and actuators
US6638293B1 (en) * 1996-02-02 2003-10-28 Transvascular, Inc. Methods and apparatus for blocking flow through blood vessels
US5624398A (en) 1996-02-08 1997-04-29 Symbiosis Corporation Endoscopic robotic surgical tools and methods
US6152899A (en) 1996-03-05 2000-11-28 Vnus Medical Technologies, Inc. Expandable catheter having improved electrode design, and method for applying energy
ATE185006T1 (de) 1996-03-06 1999-10-15 Gmd Gmbh Autonomes mobiles robotersystem für sensor- und kartengestützte navigation in einem leitungsnetzwerk
US5833603A (en) 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
US6453199B1 (en) 1996-04-01 2002-09-17 Valery Ivanovich Kobozev Electrical gastro-intestinal tract stimulator
US5830179A (en) 1996-04-09 1998-11-03 Endocare, Inc. Urological stent therapy system and method
US5782798A (en) 1996-06-26 1998-07-21 Medtronic, Inc. Techniques for treating eating disorders by brain stimulation and drug infusion
US5737279A (en) * 1996-08-07 1998-04-07 The United States Of America As Represented By The Secretary Of The Navy Retractable sensor array system
WO1998009582A1 (en) 1996-09-05 1998-03-12 Children's Medical Center Corporation Prosthetic kidney and its use for treating kidney disease
US5702432A (en) 1996-10-03 1997-12-30 Light Sciences Limited Partnership Intracorporeal light treatment of blood
US6197013B1 (en) * 1996-11-06 2001-03-06 Setagon, Inc. Method and apparatus for drug and gene delivery
US5854078A (en) 1996-11-06 1998-12-29 University Of Pittsburgh Polymerized crystalline colloidal array sensor methods
US6019729A (en) * 1996-11-15 2000-02-01 Kabushiki Kaisha Tokai-Rika-Denki-Seisakusho Sensor mechanism-equipped catheter
US6410046B1 (en) * 1996-11-19 2002-06-25 Intrabrain International Nv Administering pharmaceuticals to the mammalian central nervous system
WO1998029030A1 (en) * 1997-01-03 1998-07-09 Biosense Inc. Pressure-sensing stent
US5705293A (en) 1997-01-09 1998-01-06 Lockheed Martin Energy Research Corporation Solid state thin film battery having a high temperature lithium alloy anode
US6164284A (en) 1997-02-26 2000-12-26 Schulman; Joseph H. System of implantable devices for monitoring and/or affecting body parameters
JP2001513679A (ja) 1997-02-26 2001-09-04 アルフレッド イー マン ファウンデーション フォア サイエンティフィック リサーチ バッテリ給電式の患者の皮下挿入器具
US6695885B2 (en) 1997-02-26 2004-02-24 Alfred E. Mann Foundation For Scientific Research Method and apparatus for coupling an implantable stimulator/sensor to a prosthetic device
US6111520A (en) 1997-04-18 2000-08-29 Georgia Tech Research Corp. System and method for the wireless sensing of physical properties
IL129951A0 (en) * 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
US5954675A (en) 1997-07-07 1999-09-21 Dellagatta; Enrico Michael Method of ultrasonic therapy
US6500174B1 (en) 1997-07-08 2002-12-31 Atrionix, Inc. Circumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US6086528A (en) 1997-09-11 2000-07-11 Adair; Edwin L. Surgical devices with removable imaging capability and methods of employing same
US6226548B1 (en) 1997-09-24 2001-05-01 Surgical Navigation Technologies, Inc. Percutaneous registration apparatus and method for use in computer-assisted surgical navigation
US6585763B1 (en) 1997-10-14 2003-07-01 Vascusense, Inc. Implantable therapeutic device and method
US6409674B1 (en) 1998-09-24 2002-06-25 Data Sciences International, Inc. Implantable sensor with wireless communication
US5908435A (en) 1997-10-23 1999-06-01 Samuels; Shaun L. W. Expandable lumen device and method of use
US6240312B1 (en) * 1997-10-23 2001-05-29 Robert R. Alfano Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment
US6597954B1 (en) 1997-10-27 2003-07-22 Neuropace, Inc. System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes
US6016449A (en) 1997-10-27 2000-01-18 Neuropace, Inc. System for treatment of neurological disorders
US5947119A (en) 1997-10-31 1999-09-07 Reznick; Jerald M. Therapeutic process and apparatus for nasal passages
KR100557261B1 (ko) 1997-12-11 2006-03-07 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
US6186986B1 (en) * 1998-01-21 2001-02-13 St. Jude Medical Cardiovascular Group, Inc. Micro-catheters and methods of their manufacture
US6843800B1 (en) 1998-01-23 2005-01-18 Innercool Therapies, Inc. Patient temperature regulation method and apparatus
US6261312B1 (en) 1998-06-23 2001-07-17 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6175757B1 (en) 1998-02-02 2001-01-16 General Electric Company Luminal mapping
US6295990B1 (en) 1998-02-03 2001-10-02 Salient Interventional Systems, Inc. Methods and systems for treating ischemia
US6045551A (en) 1998-02-06 2000-04-04 Bonutti; Peter M. Bone suture
US6676637B1 (en) 1998-02-06 2004-01-13 Possis Medical, Inc. Single operator exchange fluid jet thrombectomy method
US6022316A (en) 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
US6278379B1 (en) 1998-04-02 2001-08-21 Georgia Tech Research Corporation System, method, and sensors for sensing physical properties
US6249076B1 (en) * 1998-04-14 2001-06-19 Massachusetts Institute Of Technology Conducting polymer actuator
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US7647237B2 (en) 1998-04-29 2010-01-12 Minimed, Inc. Communication station and software for interfacing with an infusion pump, analyte monitor, analyte meter, or the like
US6206914B1 (en) 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US6018682A (en) 1998-04-30 2000-01-25 Medtronic, Inc. Implantable seizure warning system
DE19822508A1 (de) 1998-05-19 1999-12-02 Daimler Chrysler Ag Verfahren zur Generierung von Ankopplungsbahnen, verwendbar zur Führung eines Fahrzeugs zu einer vorgegebenen Zielbahn
US6294281B1 (en) 1998-06-17 2001-09-25 Therasense, Inc. Biological fuel cell and method
US6322532B1 (en) 1998-06-24 2001-11-27 3M Innovative Properties Company Sonophoresis method and apparatus
US6735474B1 (en) * 1998-07-06 2004-05-11 Advanced Bionics Corporation Implantable stimulator system and method for treatment of incontinence and pain
US6497714B1 (en) 1998-07-16 2002-12-24 Olympus Optical Co., Ltd. Ultrasonic trocar
US6240316B1 (en) * 1998-08-14 2001-05-29 Advanced Bionics Corporation Implantable microstimulation system for treatment of sleep apnea
US6554798B1 (en) * 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US7235096B1 (en) 1998-08-25 2007-06-26 Tricardia, Llc Implantable device for promoting repair of a body lumen
ATE394662T1 (de) * 1998-08-26 2008-05-15 Sensors For Med & Science Inc Optisch basierte sensor-vorrichtungen
US6385472B1 (en) * 1999-09-10 2002-05-07 Stereotaxis, Inc. Magnetically navigable telescoping catheter and method of navigating telescoping catheter
US6358276B1 (en) 1998-09-30 2002-03-19 Impra, Inc. Fluid containing endoluminal stent
US6530950B1 (en) * 1999-01-12 2003-03-11 Quanam Medical Corporation Intraluminal stent having coaxial polymer member
US6314317B1 (en) 1999-02-18 2001-11-06 Biovalve Technologies, Inc. Electroactive pore
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US6464687B1 (en) 1999-03-09 2002-10-15 Ball Semiconductor, Inc. Implantable drug delivery system
US6197714B1 (en) * 1999-03-23 2001-03-06 Cryovac, Inc. Supported catalysts and olefin polymerization processes utilizing same
US6170488B1 (en) 1999-03-24 2001-01-09 The B. F. Goodrich Company Acoustic-based remotely interrogated diagnostic implant device and system
US6436120B1 (en) 1999-04-20 2002-08-20 Allen J. Meglin Vena cava filter
US20050113460A1 (en) 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US6179789B1 (en) * 1999-05-03 2001-01-30 Lily Chen Tu Enhanced radioactive stent for reduction of restenosis
US6149603A (en) 1999-05-14 2000-11-21 Ventrex, Inc. Method and apparatus for determining whether an intubated patient has been properly intubated
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
JP3490933B2 (ja) 1999-06-07 2004-01-26 ペンタックス株式会社 飲み込み型内視鏡装置
JP3793368B2 (ja) 1999-06-07 2006-07-05 ペンタックス株式会社 飲み込み型内視鏡装置
US6512949B1 (en) * 1999-07-12 2003-01-28 Medtronic, Inc. Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto
GB2352636B (en) 1999-08-03 2003-05-14 Univ College London Hospitals Improved passage-travelling device
US6263245B1 (en) 1999-08-12 2001-07-17 Pacesetter, Inc. System and method for portable implantable device interogation
CA2381951A1 (en) 1999-08-18 2001-02-22 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US6666860B1 (en) 1999-08-24 2003-12-23 Olympus Optical Co., Ltd. Electric treatment system
US6802811B1 (en) 1999-09-17 2004-10-12 Endoluminal Therapeutics, Inc. Sensing, interrogating, storing, telemetering and responding medical implants
US6440082B1 (en) * 1999-09-30 2002-08-27 Medtronic Physio-Control Manufacturing Corp. Method and apparatus for using heart sounds to determine the presence of a pulse
US6547825B1 (en) * 1999-10-04 2003-04-15 Yasuhiko Shimizu Artificial trachea
US6882881B1 (en) * 1999-10-19 2005-04-19 The Johns Hopkins University Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders
US6383162B1 (en) * 1999-11-12 2002-05-07 Paul H. Sugarbaker Apparatus and method for abdomino-pelvic chemotherapy perfusion and lavage
WO2001035928A1 (en) 1999-11-17 2001-05-25 Microchips, Inc. Microfabricated devices for the delivery of molecules into a carrier fluid
US6548982B1 (en) * 1999-11-19 2003-04-15 Regents Of The University Of Minnesota Miniature robotic vehicles and methods of controlling same
US6673042B1 (en) * 1999-11-22 2004-01-06 Wilfred J. Samson Expandable venous cannula and method of use
US6861001B2 (en) 1999-12-02 2005-03-01 The General Hospital Corporation Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon
US6592567B1 (en) 1999-12-07 2003-07-15 Chf Solutions, Inc. Kidney perfusion catheter
US6673363B2 (en) 1999-12-16 2004-01-06 Dermatrends, Inc. Transdermal and topical administration of local anesthetic agents using basic enhancers
US6450937B1 (en) 1999-12-17 2002-09-17 C. R. Bard, Inc. Needle for implanting brachytherapy seeds
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US7483743B2 (en) * 2000-01-11 2009-01-27 Cedars-Sinai Medical Center System for detecting, diagnosing, and treating cardiovascular disease
US6733446B2 (en) 2000-01-21 2004-05-11 Medtronic Minimed, Inc. Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periods
US7039453B2 (en) 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
US6920359B2 (en) 2000-02-15 2005-07-19 Advanced Bionics Corporation Deep brain stimulation system for the treatment of Parkinson's Disease or other disorders
US6816632B1 (en) 2000-02-17 2004-11-09 Wake Forest University Health Sciences Geometric motion analysis
EP1259285A1 (en) 2000-02-18 2002-11-27 University of Utah Methods for delivering agents using alternating current
NZ522128A (en) * 2000-03-31 2003-08-29 Rita Medical Systems Inc Tissue biopsy and treatment apparatus and method
US6398280B1 (en) 2000-05-11 2002-06-04 Zyvex Corporation Gripper and complementary handle for use with microcomponents
US6442413B1 (en) 2000-05-15 2002-08-27 James H. Silver Implantable sensor
US7181261B2 (en) * 2000-05-15 2007-02-20 Silver James H Implantable, retrievable, thrombus minimizing sensors
KR20020010257A (ko) 2000-07-28 2002-02-04 김인광 로봇 시스템에서의 자기위치 인식 장치 및 방법
US6402678B1 (en) 2000-07-31 2002-06-11 Neuralieve, Inc. Means and method for the treatment of migraine headaches
US6921413B2 (en) 2000-08-16 2005-07-26 Vanderbilt University Methods and devices for optical stimulation of neural tissues
US7840271B2 (en) 2000-09-27 2010-11-23 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US6898464B2 (en) * 2000-10-05 2005-05-24 Innersea Technology Optical telemetry of data and power for wireless biomedical sensors and actuators
WO2002030401A2 (en) 2000-10-11 2002-04-18 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
US6514237B1 (en) * 2000-11-06 2003-02-04 Cordis Corporation Controllable intralumen medical device
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6591137B1 (en) 2000-11-09 2003-07-08 Neuropace, Inc. Implantable neuromuscular stimulator for the treatment of gastrointestinal disorders
US6679893B1 (en) 2000-11-16 2004-01-20 Chestnut Medical Technologies, Inc. Grasping device and method of use
US6607553B1 (en) 2000-11-17 2003-08-19 B. Braun Medical, Inc. Method for deploying a thermo-mechanically expandable stent
US8372139B2 (en) 2001-02-14 2013-02-12 Advanced Bio Prosthetic Surfaces, Ltd. In vivo sensor and method of making same
JP2002153569A (ja) 2000-11-20 2002-05-28 Motokuni Mori 鼻 栓
US6950707B2 (en) 2000-11-21 2005-09-27 Advanced Bionics Corporation Systems and methods for treatment of obesity and eating disorders by electrical brain stimulation and/or drug infusion
EP1341476A2 (en) 2000-12-01 2003-09-10 Nephros Therapeutics, Inc. Intrasvascular drug delivery device and use therefor
US6384741B1 (en) 2001-01-16 2002-05-07 O'leary, Sr. Jerry P. Apparatus and method for providing high mounted view of traffic
US7553276B2 (en) 2001-01-16 2009-06-30 Given Imaging Ltd. Method and device for imaging body lumens
US6735475B1 (en) 2001-01-30 2004-05-11 Advanced Bionics Corporation Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain
US6754536B2 (en) * 2001-01-31 2004-06-22 Medtronic, Inc Implantable medical device affixed internally within the gastrointestinal tract
US20020116029A1 (en) 2001-02-20 2002-08-22 Victor Miller MRI-compatible pacemaker with power carrying photonic catheter and isolated pulse generating electronics providing VOO functionality
US20020116034A1 (en) 2001-02-20 2002-08-22 Victor Miller Controllable, wearable MRI-compatible pacemaker with power carrying photonic catheter and VOO functionality
US6592549B2 (en) 2001-03-14 2003-07-15 Scimed Life Systems, Inc. Rapid exchange stent delivery system and associated components
US20020188323A1 (en) 2001-03-19 2002-12-12 Remon Medical Technologies Ltd. Methods, systems and devices for in vivo electrochemical production of therapeutic agents
EP1418845A4 (en) 2001-04-04 2006-06-07 Given Imaging Ltd IMAGING DEVICE IN VIVO WITH INDUCTION DRIVE
US20020147480A1 (en) 2001-04-04 2002-10-10 Mamayek Donald S. Treatment of lipid pool
US6616676B2 (en) 2001-04-10 2003-09-09 Scimed Life Systems, Inc. Devices and methods for removing occlusions in vessels
US7083593B2 (en) 2001-04-18 2006-08-01 Advanced Bionics Corporation Programmable implantable pump with accessory reservoirs and multiple independent lumen catheter
US6676692B2 (en) 2001-04-27 2004-01-13 Intek Technology L.L.C. Apparatus for delivering, repositioning and/or retrieving self-expanding stents
US20040225326A1 (en) 2001-05-07 2004-11-11 Weiner Mike L. Apparatus for the detection of restenosis
US20020169436A1 (en) 2001-05-08 2002-11-14 Hitinder Gurm Percutaneous method of preventing distal embolisation while maintaining adequate distal perfusion in percutaneous interventional procedures
KR100402920B1 (ko) 2001-05-19 2003-10-22 한국과학기술연구원 마이크로 로봇
KR100426613B1 (ko) 2001-05-19 2004-04-08 한국과학기술연구원 마이크로 로봇 구동시스템
US6733485B1 (en) * 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
US6890303B2 (en) 2001-05-31 2005-05-10 Matthew Joseph Fitz Implantable device for monitoring aneurysm sac parameters
US6626940B2 (en) 2001-06-15 2003-09-30 Scimed Life Systems, Inc. Medical device activation system
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
US7013177B1 (en) 2001-07-05 2006-03-14 Advanced Bionics Corporation Treatment of pain by brain stimulation
AU2002317466B2 (en) 2001-07-12 2008-02-28 Given Imaging Ltd Device and method for examining a body lumen
US7547321B2 (en) * 2001-07-26 2009-06-16 Alveolus Inc. Removable stent and method of using the same
US6951536B2 (en) * 2001-07-30 2005-10-04 Olympus Corporation Capsule-type medical device and medical system
WO2003013374A1 (en) 2001-08-06 2003-02-20 Penn State Research Foundation Multifunctional tool and method for minimally invasive surgery
US7063714B2 (en) * 2001-08-22 2006-06-20 Gore Enterprise Holdings, Inc. Apparatus and methods for treating stroke and controlling cerebral flow characteristics
PT1291034E (pt) * 2001-09-10 2006-09-29 Thermocore Medical Systems Nv Dispositivo de posicionamento de cateter
US6764441B2 (en) 2001-09-17 2004-07-20 Case Western Reserve University Peristaltically self-propelled endoscopic device
US6860867B2 (en) * 2001-09-20 2005-03-01 The Regents Of The University Of California Method of interventional surgery
JP2005503241A (ja) * 2001-09-27 2005-02-03 ガリル メディカル リミテッド クライオプラスティ装置および方法
US6770027B2 (en) * 2001-10-05 2004-08-03 Scimed Life Systems, Inc. Robotic endoscope with wireless interface
US6849183B2 (en) 2002-08-13 2005-02-01 Transvivo, Inc. Method and apparatus for therapeutic apheresis
US6939376B2 (en) 2001-11-05 2005-09-06 Sun Biomedical, Ltd. Drug-delivery endovascular stent and method for treating restenosis
US20030153866A1 (en) 2001-11-09 2003-08-14 Long Gary L. Self-propelled, intraluminal device with hollow, cylindrical head and method of use
US6866626B2 (en) 2001-11-09 2005-03-15 Ethicon-Endo Surgery, Inc. Self-propelled, intraluminal device with working channel and method of use
US20030093031A1 (en) 2001-11-09 2003-05-15 Long Gary L. Self-propelled, intraluminal device with medical agent applicator and method of use
KR100417163B1 (ko) * 2001-11-12 2004-02-05 한국과학기술연구원 마이크로 캡슐형 로봇
US7498714B2 (en) 2003-09-24 2009-03-03 Microfabrica Inc. Multi-layer three-dimensional structures having features smaller than a minimum feature size associated with the formation of individual layers
US20050121411A1 (en) 2002-10-29 2005-06-09 Microfabrica Inc. Medical devices and EFAB methods and apparatus for producing them
US7372616B2 (en) 2001-12-06 2008-05-13 Microfabrica, Inc. Complex microdevices and apparatus and methods for fabricating such devices
DE10162054C2 (de) * 2001-12-17 2003-11-27 Dorma Gmbh & Co Kg Verbindungselement für eine gläserne Stützen-Riegel-Konstruktion
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
WO2003062758A1 (en) 2002-01-18 2003-07-31 The Board Of Trustees Of The University Of Illinois Microscale out-of-plane anemometer
US20030163177A1 (en) 2002-01-18 2003-08-28 Eggers Philip E. System method and apparatus for localized heating of tissue
US6855115B2 (en) 2002-01-22 2005-02-15 Cardiomems, Inc. Implantable wireless sensor for pressure measurement within the heart
US6828908B2 (en) 2002-02-06 2004-12-07 Ronald Scott Clark Locator system with an implanted transponder having an organically-rechargeable battery
US6939290B2 (en) 2002-02-11 2005-09-06 Given Imaging Ltd Self propelled device having a magnetohydrodynamic propulsion system
US6958034B2 (en) 2002-02-11 2005-10-25 Given Imaging Ltd. Self propelled device
US7236821B2 (en) * 2002-02-19 2007-06-26 Cardiac Pacemakers, Inc. Chronically-implanted device for sensing and therapy
CA2476764A1 (en) 2002-02-19 2003-08-28 Syntherica Corporation Compositions and methods for surrogate antibody modulation of an immune response and transport
AU2003215330B2 (en) 2002-02-21 2008-03-13 Encelle, Inc. Immobilized bioactive hydrogel matrices as surface coatings
US6889091B2 (en) * 2002-03-06 2005-05-03 Medtronic, Inc. Method and apparatus for placing a coronary sinus/cardiac vein pacing lead using a multi-purpose side lumen
JP2005522162A (ja) * 2002-03-18 2005-07-21 エスアールアイ インターナショナル 流体を移動させる電気活性ポリマーデバイス
US7797033B2 (en) 2002-04-08 2010-09-14 Smart Pill Corporation Method of using, and determining location of, an ingestible capsule
US20030216622A1 (en) 2002-04-25 2003-11-20 Gavriel Meron Device and method for orienting a device in vivo
GB2389791B (en) * 2002-04-30 2006-12-13 Steven Gill Implantable drug delivery pump
US7368190B2 (en) 2002-05-02 2008-05-06 Abbott Diabetes Care Inc. Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods
US6755802B2 (en) * 2002-05-06 2004-06-29 Beckman Coulter, Inc. Whole blood sampling device
EP1507492A1 (en) * 2002-05-10 2005-02-23 Cordis Corporation Method of making a medical device having a thin wall tubular membrane over a structural frame
EP2275157A3 (en) * 2002-05-16 2012-02-15 Scott Laboratories, Inc. Kits of medical supplies for sedation and analgesia
EP1505912A4 (en) 2002-05-17 2011-04-20 Dvl Acquisition Sub Inc SURGICAL METHOD AND METHOD OF USE
US20030220556A1 (en) 2002-05-20 2003-11-27 Vespro Ltd. Method, system and device for tissue characterization
US7003352B1 (en) 2002-05-24 2006-02-21 Advanced Bionics Corporation Treatment of epilepsy by brain stimulation
US6833003B2 (en) 2002-06-24 2004-12-21 Cordis Neurovascular Expandable stent and delivery system
US7314484B2 (en) 2002-07-02 2008-01-01 The Foundry, Inc. Methods and devices for treating aneurysms
US6925357B2 (en) 2002-07-25 2005-08-02 Intouch Health, Inc. Medical tele-robotic system
US7515953B2 (en) * 2002-08-01 2009-04-07 The Johns Hopkins University Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence
KR100482275B1 (ko) * 2002-08-09 2005-04-13 한국과학기술연구원 마이크로 캡슐형 로봇
WO2004014227A1 (en) * 2002-08-13 2004-02-19 Given Imaging Ltd. System for in vivo sampling and analysis
US6991617B2 (en) 2002-08-21 2006-01-31 Hektner Thomas R Vascular treatment method and device
US6776165B2 (en) 2002-09-12 2004-08-17 The Regents Of The University Of California Magnetic navigation system for diagnosis, biopsy and drug delivery vehicles
AU2003263859A1 (en) 2002-09-20 2004-04-08 Enventure Global Technology Protective sleeve for expandable tubulars
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
US8449452B2 (en) 2002-09-30 2013-05-28 Given Imaging Ltd. In-vivo sensing system
US7794494B2 (en) 2002-10-11 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices
AU2003301370A1 (en) 2002-10-15 2004-05-04 Medtronic Inc. Multi-modal operation of a medical device system
US6936003B2 (en) 2002-10-29 2005-08-30 Given Imaging Ltd In-vivo extendable element device and system, and method of use
US7037344B2 (en) 2002-11-01 2006-05-02 Valentx, Inc. Apparatus and methods for treatment of morbid obesity
US20040133147A1 (en) * 2002-11-06 2004-07-08 Woo Sang Hoon Intestinal bypass device to treat obesity
US7039450B2 (en) * 2002-11-15 2006-05-02 Biosense Webster, Inc. Telescoping catheter
US7697972B2 (en) * 2002-11-19 2010-04-13 Medtronic Navigation, Inc. Navigation system for cardiac therapies
US7226410B2 (en) 2002-12-05 2007-06-05 Ethicon-Endo Surgery, Inc. Locally-propelled, intraluminal device with cable loop track and method of use
US6959215B2 (en) 2002-12-09 2005-10-25 Northstar Neuroscience, Inc. Methods for treating essential tremor
US7037343B2 (en) * 2002-12-23 2006-05-02 Python, Inc. Stomach prosthesis
EP1587407B1 (en) 2002-12-26 2012-03-07 Given Imaging Ltd. Immobilizable in vivo sensing device
US7628753B2 (en) 2002-12-30 2009-12-08 Given Imaging, Ltd. Method for in vivo sensing
US7228162B2 (en) * 2003-01-13 2007-06-05 Isense Corporation Analyte sensor
US20040267240A1 (en) 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20040152988A1 (en) 2003-01-31 2004-08-05 Weirich John Paul Capsule imaging system
IL161096A (en) 2003-03-27 2008-08-07 Given Imaging Ltd An instrument, system, and method for measuring a cascade of intracorporeal concentrations
JP2004298241A (ja) 2003-03-28 2004-10-28 Olympus Corp カプセル内視鏡
US20040199246A1 (en) 2003-04-02 2004-10-07 Scimed Life Systems, Inc. Expandable stent
KR20040086940A (ko) 2003-04-03 2004-10-13 엘지전자 주식회사 이미지센서를 채용한 이동로봇 및 그의 이동거리 측정방법
US20040199054A1 (en) 2003-04-03 2004-10-07 Wakefield Glenn Mark Magnetically propelled capsule endoscopy
US20050278020A1 (en) 2003-04-08 2005-12-15 Xingwu Wang Medical device
US20050079132A1 (en) 2003-04-08 2005-04-14 Xingwu Wang Medical device with low magnetic susceptibility
US20050182482A1 (en) 2003-04-08 2005-08-18 Xingwu Wang MRI imageable medical device
US20050107870A1 (en) * 2003-04-08 2005-05-19 Xingwu Wang Medical device with multiple coating layers
US7736300B2 (en) * 2003-04-14 2010-06-15 Softscope Medical Technologies, Inc. Self-propellable apparatus and method
US7383071B1 (en) * 2003-04-25 2008-06-03 United States Of America As Represented By The Secretary Of The Navy Microsensor system and method for measuring data
US7297113B1 (en) 2003-04-25 2007-11-20 United States Of America As Represented By The Secretary Of The Navy Microsensor system and method for measuring data
US7214182B2 (en) 2003-04-25 2007-05-08 Olympus Corporation Wireless in-vivo information acquiring system, body-insertable device, and external device
DE10323216B3 (de) 2003-05-22 2004-12-23 Siemens Ag Endoskopieeinrichtung
ATE364348T1 (de) 2003-06-17 2007-07-15 Raymond Moser Implantierbare und wiederherausziehbare sensorvorrichtung
US20050004553A1 (en) * 2003-07-02 2005-01-06 Medtronic Ave, Inc. Sheath catheter having variable over-the-wire length and methods of use
US7042184B2 (en) 2003-07-08 2006-05-09 Board Of Regents Of The University Of Nebraska Microrobot for surgical applications
US7126303B2 (en) 2003-07-08 2006-10-24 Board Of Regents Of The University Of Nebraska Robot for surgical applications
US7066180B2 (en) * 2003-07-09 2006-06-27 Airmatrix Technologies, Inc. Method and system for measuring airflow of nares
US20050021023A1 (en) 2003-07-23 2005-01-27 Scimed Life Systems, Inc. System and method for electrically determining position and detachment of an implantable device
US20050027236A1 (en) * 2003-07-30 2005-02-03 Medtronic Ave, Inc. Aspiration catheter having a variable over-the-wire length and methods of use
WO2005018443A1 (en) 2003-08-15 2005-03-03 Animas Technologies Llc Microprocessors, devices, and methods for use in monitoring of physiological analytes
EP1677714A4 (en) 2003-09-18 2008-01-16 Advanced Bio Prothestic Surfac MEDICAL DEVICE INTEGRATING FUNCTIONALITIES OF MICROELECTROMECHANICAL SYSTEMS, AND METHODS OF MANUFACTURING THE SAME
DE10343494B4 (de) 2003-09-19 2006-06-14 Siemens Ag Magnetisch navigierbare Einrichtung für den Einsatz auf dem Gebiet der medizinischen Endoskopie
US20050065592A1 (en) 2003-09-23 2005-03-24 Asher Holzer System and method of aneurism monitoring and treatment
US20050153309A1 (en) 2003-12-22 2005-07-14 David Hoon Method and apparatus for in vivo surveillance of circulating biological components
US7625338B2 (en) 2003-12-31 2009-12-01 Given Imaging, Ltd. In-vivo sensing device with alterable fields of view
US20050171418A1 (en) 2004-01-08 2005-08-04 Tah-Yeong Lin Capsule endoscopy system
US7572228B2 (en) 2004-01-13 2009-08-11 Remon Medical Technologies Ltd Devices for fixing a sensor in a lumen
US7002331B2 (en) 2004-01-13 2006-02-21 Delta Electronics, Inc. Modular power supply system including a power status signal generator to perform fast sag detection to input peak voltage
JP4455067B2 (ja) 2004-01-14 2010-04-21 オリンパス株式会社 カプセル型内視鏡装置
US8082024B2 (en) 2004-01-16 2011-12-20 Alfano Robert R Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy
ITPI20040008A1 (it) 2004-02-17 2004-05-17 Dino Accoto Capsula robotica per applicazioni biomediche intracorporee
US7369509B2 (en) * 2004-03-04 2008-05-06 Acterna Llc System and method for facilitating network troubleshooting
US8915957B2 (en) 2004-03-11 2014-12-23 Alcatel Lucent Drug delivery stent
US7365614B2 (en) 2004-03-22 2008-04-29 Mobius Microsystems, Inc. Integrated clock generator and timing/frequency reference
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US8163269B2 (en) 2004-04-05 2012-04-24 Carpenter Kenneth W Bioactive stents for type II diabetics and methods for use thereof
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US7212110B1 (en) 2004-04-19 2007-05-01 Advanced Neuromodulation Systems, Inc. Implantable device and system and method for wireless communication
US8361013B2 (en) 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
WO2005102458A2 (en) * 2004-04-19 2005-11-03 The Board Of Trustees, The Leland Stanford Junior University Airway implant devices and methods of use
US20050234440A1 (en) 2004-04-19 2005-10-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System with a sensor for perfusion management
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US20070010868A1 (en) * 2004-04-19 2007-01-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Lumenally-active device
US7857767B2 (en) 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
US8512219B2 (en) * 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
US7125382B2 (en) 2004-05-20 2006-10-24 Digital Angel Corporation Embedded bio-sensor system
US20050277839A1 (en) 2004-06-10 2005-12-15 Honeywell International, Inc. Wireless flow measurement in arterial stent
EP1618831A3 (en) 2004-06-29 2006-04-19 Nippon Cable System Inc. A moving device in pipe lines
US7596403B2 (en) 2004-06-30 2009-09-29 Given Imaging Ltd. System and method for determining path lengths through a body lumen
US7857369B2 (en) 2004-06-30 2010-12-28 Case Western Reserve University Biologically inspired gripping device
US7729761B2 (en) * 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
US8146591B2 (en) * 2004-08-31 2012-04-03 Ethicon Endo-Surgery, Inc. Capnometry system for use with a medical effector system
US7020231B1 (en) 2004-10-21 2006-03-28 Delphi Technologies, Inc. Technique for creating extended bit timer on a time processing unit
US7486967B2 (en) 2005-04-13 2009-02-03 Lemko Corporation System, method, and device for providing communications using a distributed mobile architecture
US20060169294A1 (en) 2004-12-15 2006-08-03 Kaler Karan V Inertial navigation method and apparatus for wireless bolus transit monitoring in gastrointestinal tract
US8235055B2 (en) 2005-01-11 2012-08-07 Uti Limited Partnership Magnetic levitation of intraluminal microelectronic capsule
KR100702155B1 (ko) 2005-05-12 2007-04-02 한국과학기술연구원 캡슐형 마이크로 로봇 구동 시스템
US9314222B2 (en) 2005-07-07 2016-04-19 Stereotaxis, Inc. Operation of a remote medical navigation system using ultrasound image
US7398734B1 (en) 2006-03-09 2008-07-15 The United States Of America As Represented By The Secretary Of The Navy MEMS resettable timer
US7744542B2 (en) * 2006-04-20 2010-06-29 Cardiac Pacemakers, Inc. Implanted air passage sensors
CA3068216C (en) 2006-06-22 2023-03-07 Board Of Regents Of The University Of Nebraska Magnetically coupleable robotic devices and related methods
US7669475B2 (en) 2006-09-28 2010-03-02 Rosemount Aerospace Inc. System and method for measuring rotational movement about an axis
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
KR100859093B1 (ko) 2007-04-30 2008-09-17 광주과학기술원 Rfid를 이용한 내비게이션 장치 및 그 방법
US8192360B2 (en) 2007-09-25 2012-06-05 Pacesetter, Inc. Implantable body fluid analyzer
US8401659B2 (en) 2008-01-15 2013-03-19 Cardiac Pacemakers, Inc. Implantable medical device with wireless communications
ES2401166T3 (es) 2008-09-16 2013-04-17 Scuola Superiore Di Studi Universitari E Di Perfezionamento Sant'anna Cápsula sin hilos que libera una pinza quirúrgica

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101133246B (zh) * 2005-02-21 2012-01-11 皇家飞利浦电子股份有限公司 基于致动器元件的微流体系统
CN102370476A (zh) * 2011-09-28 2012-03-14 上海交通大学 心血管血液流速传感器
CN102370476B (zh) * 2011-09-28 2013-07-10 上海交通大学 心血管血液流速传感器
CN103826694A (zh) * 2011-09-30 2014-05-28 柯惠有限合伙公司 能量传递装置以及使用方法
CN103826694B (zh) * 2011-09-30 2017-03-22 柯惠有限合伙公司 能量传递装置以及使用方法
CN106823131A (zh) * 2011-09-30 2017-06-13 柯惠有限合伙公司 能量传递装置以及使用方法
CN106823131B (zh) * 2011-09-30 2019-12-20 柯惠有限合伙公司 能量传递装置以及使用方法

Also Published As

Publication number Publication date
US8092549B2 (en) 2012-01-10
US20060069425A1 (en) 2006-03-30
GB2432537B (en) 2010-01-06
DE112005002338T5 (de) 2009-02-05
KR101255377B1 (ko) 2013-04-17
GB2432537A (en) 2007-05-30
GB0706802D0 (en) 2007-05-16
JP2008514284A (ja) 2008-05-08
KR20070063559A (ko) 2007-06-19
WO2006036633A3 (en) 2006-11-02
WO2006036633A2 (en) 2006-04-06

Similar Documents

Publication Publication Date Title
CN101065077A (zh) 一种带纤毛的类支架系统
Zhalmuratova et al. Reinforced gels and elastomers for biomedical and soft robotics applications
Ricotti et al. Biohybrid actuators for robotics: A review of devices actuated by living cells
Palagi et al. Bioinspired microrobots
Seok et al. Peristaltic locomotion with antagonistic actuators in soft robotics
Ceylan et al. Mobile microrobots for bioengineering applications
Ng et al. Locomotion of miniature soft robots
Lin et al. The emerging technology of biohybrid micro-robots: a review
Tsang et al. Roads to smart artificial microswimmers
Chan et al. Utilization and control of bioactuators across multiple length scales
Carlsen et al. Bio‐hybrid cell‐based actuators for microsystems
CN105500380B (zh) 串并融合伪足软体机器人
Yu et al. Micro-/nanorobots propelled by oscillating magnetic fields
WO2008063473A2 (en) Nanorobotics system
Zhao et al. Magnetic actuated shape-memory helical microswimmers with programmable recovery behaviors
Wang et al. Magnetic soft robots: Design, actuation, and function
Paprotny et al. Small-scale robotics: An introduction
Garcia et al. The role of soft robotic micromachines in the future of medical devices and personalized medicine
Hawkes et al. Design of materials and mechanisms for responsive robots
Liu et al. Review of the research progress in soft robots
Shen et al. Magnetically driven microrobots: Recent progress and future development
Zhu et al. External Field‐Driven Untethered Microrobots for Targeted Cargo Delivery
Wang et al. Review of bionic crawling micro-robots
Whenish et al. Design and performance of additively manufactured lightweight bionic hand
Craddock et al. Biorobotics: an overview of recent innovations in artificial muscles

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20071031