CN101467910B - In vivo ultrasound lithotripter - Google Patents

In vivo ultrasound lithotripter Download PDF

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Publication number
CN101467910B
CN101467910B CN2008100851639A CN200810085163A CN101467910B CN 101467910 B CN101467910 B CN 101467910B CN 2008100851639 A CN2008100851639 A CN 2008100851639A CN 200810085163 A CN200810085163 A CN 200810085163A CN 101467910 B CN101467910 B CN 101467910B
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frequency
needle
direct digital
signal
ultrasonic transducer
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CN101467910A (en
Inventor
李平
李春
梁希庭
熊六林
汪东
李小雪
王君琳
雒自清
崔杰
石长亮
于晋生
费兴波
肖灵
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BEIJING ANHEJIABAOER TECHNOLOGY Co.,Ltd.
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Beijing Aomaite Science & Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement

Abstract

The invention relates to an intracorporal ultrasonic lithotripter consisting of an ultrasonic transducer and an automatic frequency tracking system, wherein, the ultrasonic transducer comprises more than two groups of piezoelectric ceramic pieces, a counterweight, the piezoelectric ceramic pieces and an amplitude transformer are connected together through hollow bolts, and the ultrasonic transducer is installed in the housing handle made of fire-resistant resin materials. A broken stone probe is connected with the front end of the amplitude transformer, a back cover is connected with the back end of the housing handle by screw threads, a pneumatic stone breaking device or a laser stone breaking device can be connected after the back cover is took down, an air regulation device which can regulate the adsorptive pressure in the operation process conveniently is installed on the side of the back end of the housing handle. The whole transducer can be fumigated in 125 DEG C. The automatic frequency tracking system adopts DDS and large-scale programmable devices, a direct digital frequency synthesizer to generate driving signals of the ultrasonic transducer and a strategy of autotracking after scanning search, thus, the automatic frequency tracking system adapts to the discreteness of the transducer and overcomes effects of a variety of causes on the resonance points.

Description

Ultrasound lithotripter in a kind of body
Technical field
The present invention relates to be used for the Medical Instruments of minimally-invasive treatment urinary system calculus, ultrasound lithotripter in particularly a kind of body.
Background technology
For general renal calculus, ureteral calculus and vesical calculus, can adopt the extracorporeal shock-wave lithotripsy (ESWL) method to carry out rubble, or adopt method rubbles such as medical holmium laser, medical neodymium laser, pneumatic ballistic lithotripsy.Extracorporeal shock-wave lithotripsy (ESWL), ultrasonic rubble are only effective to about 15% frangible microlith.Medical holmium laser, medical neodymium laser and pneumatic ballistic lithotripsy can solve about 80% calculus patient's a treatment difficult problem.These Therapeutic Method are undertaken by cystoscope, ureter soft lens, and the treatment end of laser fiber or equipment arrives at stone location by urethra, by laser energy or pneumatic ballistic lithotripsy energy, calculus are smashed then.More than this several method all need not to operate on, to the human zero damage or damage minimumly, be that most calculus such as renal calculus, ureteral calculus and vesical calculus patient are ready the Therapeutic Method accepted.Shortcoming be above-mentioned Therapeutic Method to part renal calculus, especially obstinate hard kidney inferior calyx calculus and vesical calculus are usually powerless, and when treatment can only rubble, can not clear then and there stone, stay the hidden danger that recurrence of hepatolithiasis and rubble stop up urinary tract.Rubble is a kind of technology of the calculus of minimally-invasive treatment preferably in the Ultrasonographic, the general rubble probe that adopts hollow, cooperate negative pressure of vacuum to attract equipment, when calculus being smashed with ultrasound wave, utilize negative pressure that the calculus sucking-off is external, realize the therapeutic purposes of the clear stone of rubble, the benefit of this method is that stone is thorough, general two days of treatment back just can rehabilitation, and is not easy to recur.The company that produces this ultrasonic rock crushing plant at present is few, mainly contains the R-Wolf company of Germany and the EMS company of Switzerland, and the rock crushing plant of this two company all has weak point again.
Wherein, the structure of the equipment of Wolf roughly as shown in Figure 1, ultrasonic rubble transducer in this body comprises: rustless steel needle tubing 1, union joint 2, union joint O type sealing ring 3, elastic tube 4, horn 5, horn O type sealing ring 6, piezoelectric ceramic piece 7, counterweight 9, hold-down bolt 10, shell 11, sleeve O type sealing ring 12, gas-tpe fitting O type sealing ring 16, gas-tpe fitting 17, hold-down bolt O type sealing ring 19, suction stone conduit 20, insulated sleeve 21, electrode slice 22, cone medicated cap 23, lead 24, conductor interface medicated cap 25, conductor interface seat 26.Because between shell and counterweight, the horn etc. is the crimping of simple O type ring, horn also is the general copper alloy material of performance, so its mechanical quality factor is lower, the amplitude amplification is also less, and ultrasonic rubble ability is significantly weakened; Add the interface that is not equipped with air pressure trajectory and rock crushing plants such as holmium laser, neodymium laser, volume is big when running into, the harder calculus of quality just seems powerless.
Though the equipment of EMS has passed through the improvement of several generations, realized ultrasonic and the ballistic combination of air pressure, but operation is not very convenient in its art, negative pressure intensity can only be in vacuum suction equipment adjusted, the patient can't arbitrary control suction size, and when probe contacts soft tissue because of carelessness, release in time, both can cause needle tubing obstruction, transducer heating, easily bodily tissue damaged again.
On the other hand, the performance of ultrasonic transducer is the key factor of decision ultrasound lithotripter rubble ability, typical ultrasonic transducer has very high quality factor (Q-value), have precipitous resonance curve, only be operated in its resonant frequency point and just have big mechanical activation amplitude and high motor conversion efficiency.Therefore, the drive circuit of ultrasonic transducer should encourage with its resonant frequency signal.
Yet, the resonant frequency of actual transducer discrete often with change.This be because: the difference of (1) transducer piezoceramic material, manufacturing process in manufacture process; (2) variation of the load characteristic that transducer mated; (3) in use self parameter in time, temperature etc. changes for transducer.So the drive circuit of transducer should have to change and remain with instant resonant frequency signal from its resonant frequency of motion tracking and carries out driving capability.
Typical in the past automatic frequency tracking scheme adopts phase-locked loop circuit to realize, generally comprise: phase comparator (analog or digital) and voltage controlled oscillator (simulation) or digital controlled oscillator (numeral) are formed.This traditional scheme develops into simulation, digital hybrid circuit from early stage full analog circuit, and nowadays totally digitilized implementation has been arranged.List of references has: the patentee number is the phase-locking type frequency-tracking ultrasonic polishing machine of CN2248118Y for great, the patent announcement of a surname; With the patentee be Wen Youkui, patent announcement number transducer for the band automatic frequency tracking of CN2160473Y.Wherein, patent CN2248118Y adopts voltage controlled oscillator to produce the pumping signal of transducer, and the current feedback signal of transducer sampled, produce pumping signal with voltage controlled oscillator and do bit comparison mutually, detect both phase contrasts, then, feed back to voltage controlled oscillator to realize the purpose of frequency-tracking by control circuit.
This scheme has four remarkable shortcomings: the one, and the voltage-frequency curve of voltage controlled oscillator is not to be linear change fully, the frequency of sinusoidal signal is then pressed linear relationship calculating fully, and there is error in this with regard to the resonant frequency that causes voltage controlled oscillator output sinusoidal signal frequency and transducer; The 2nd, what its phase comparator adopted is XOR gate, this phase comparator requires than higher the dutycycle of two input signals, must guarantee to equate just can realize accurate frequency-tracking, and this is difficult to accomplish usually as the current feedback signal of phase bit comparison and the dutycycle strictness of voltage controlled oscillator pumping signal; The 3rd, because phaselocked loop is analog quantity control, be unfavorable for that phase signal is carried out digitized processing is beneficial to automatic frequency tracking; The 4th, when the transducer individual variation is bigger, be difficult to realize the automatic frequency tracking of the different transducers that individual variation is bigger with the phaselocked loop of same electrical quantity, this is unfavorable for large-scale industrial production very much.
In addition, control to DDS (Direct Digital synthesizer, Dirrect Digital Synthesizer) in the past mainly realizes by microcontroller serial port, because the microcontroller serial port speed ratio is lower, do automatic frequency tracking and have communication performance bottleneck, poor effect with its control DDS.
Summary of the invention
The objective of the invention is to: for overcoming singlehanded difficulty of operating adjust blood pressure needle-valve and air bleeding valve simultaneously, the ultrasonic lithotrite rubble ability of ultrasonic rubble transducer in the existing body, big or small calculus attraction smashes and is not easy operation to difference, and owing to be drawn onto the needle tubing blocking problem that soft tissue causes, simultaneously, for solve with the not high transducer that causes of precision of the frequency-tracking that adopts phase-locked loop circuit to realize to exist in the automatic frequency tracking scheme fully delivered power and phase comparator to the dutycycle requirement of two input signals than problem of higher, thereby provide a kind of body interior ultrasound lithotripter.
For achieving the above object, ultrasound lithotripter in a kind of body provided by the invention comprises it is characterized in that the automatic frequency tracking system of ultrasonic transducer and ultrasonic transducer,
Described transducer comprises: rustless steel needle tubing 1, union joint 2, union joint O type sealing ring 3, elastic tube 4, horn 5, horn O type sealing ring 6, piezoelectric ceramic piece 7, counterweight 9, hold-down bolt 10, shell 11, gas-tpe fitting O type sealing ring 16, gas-tpe fitting 17, hold-down bolt O type sealing ring 19, suction stone conduit 20, insulated sleeve 21, electrode slice 22, cone medicated cap 23, lead 24, conductor interface medicated cap 25 and conductor interface seat 26; It is characterized in that, the conductor interface seat 26 on described shell 11 tops and on conductor interface medicated cap 25, be located at the position of departing from shell 11 axis; The top that is positioned at hold-down bolt 10 in the described shell 11 also includes adapter 18, described adapter 18 corresponding to conductor interface seat 26 and on conductor interface medicated cap 25, be axially arranged with peripheral through hole in the position of departing from shell 11 axis along being parallel to shell 11, its upper end is communicated with conductor interface seat 26, is used to hold lead; Described adapter 18 is the four-way structure, and the front end of the central through hole that it is axial is communicated with inhales stone conduit 20, and the rear end of this central through hole is fixedly connected on the top of shell 11; Described adapter 18 departs from peripheral through hole and radially offers two radial direction through hole, is respectively applied for to be communicated with Pressure Regulation Exhaust valve 13 and gas-tpe fitting 17, and the junction of gas-tpe fitting 17 and adapter 18 is pressed with gas-tpe fitting O type sealing ring 16;
The automatic frequency tracking system of described ultrasonic transducer as signal source, adopts frequency sweep-tracking strategy with Direct Digital Frequency Synthesizers, realizes the automatic frequency tracking of total digitalization, comprising:
One direct digital synthesizer is used to produce the sine wave signal of frequency adjustable, and after power amplifier amplifies, drives ultrasonic transducer with matching network;
One sampling loop is used for obtaining from the power take-off of ultrasonic transducer one group of voltage and current feedback signal of ultrasonic transducer, and this group signal is delivered to phase-comparison circuit, delivered to main control singlechip through amplitude adjusting circuit through filtering shaping circuit respectively;
One main control singlechip, main control singlechip is according to the triggering signal and the frequency word of the operating frequency range control DDS controller of predetermined transducer itself, and the DDS controller sent the cline frequency scan instruction, make DDS controller output frequency continually varying sine wave; Simultaneously, described main control singlechip is the amplitude of the sampling current feedback signal of real time monitoring transducer also, half when the amplitude of the current feedback signal current amplitude during greater than ultrasonic transducer resonance, the frequency word that shows main control singlechip is basically near the resonant frequency point of transducer the time, main control singlechip will allow the DDS controller stop frequency sweep, sends automatic trace command; Ultrasonic transducer when resonance point is worked, does not have current signal, and current amplitude is zero, has only ultrasonic transducer current feedback signal just to be arranged near being operated in resonance point, and current amplitude is non-vanishing, and operating frequency is near more apart from resonance point, and current amplitude is big more;
One phase-comparison circuit, be used for the voltage and current feedback signal after handling through filtering shaping circuit is carried out the phase bit comparison, and phase difference signal inputed to differ summation circuit to produce the frequency word of DDS chip, by the DDS controller this frequency word is passed to the DDS chip to change its output signal frequency automatically, thereby, make ultrasonic transducer always work near the resonance point, realize automatic frequency tracking.
As a kind of improvement of the present invention, the rear end of described central through hole can connect corresponding air pressure trajectory or laser lithotripsy device; Or the bonnet 15 that has been threaded, and between rear end and bonnet, be pressed with sealing gasket 14.
As another kind of improvement the of the present invention, described Pressure Regulation Exhaust valve 13 comprises needle valve body, needle-valve spool, exhasut valve stem, aerofluxus bonnet, compression spring and the O type rubber ring of coaxial setting; Described needle valve body is cylindrical, and its outer surface is provided with and is used for the screw thread that is connected with tee T on the extraneous gas piping; The lower end of this needle valve body is arranged with O type rubber ring, by compressing the sealing between this O type rubber ring assurance needle valve body and the tee T; Described needle-valve spool is roughly T-shaped, from top to bottom is sheathed in the described needle valve body; The outer surface on described needle-valve spool top and the upper inside surface of described needle valve body are threaded, leave the gap between the outer surface of described needle-valve spool bottom and the lower inner surface of described needle valve body, described needle-valve spool and described needle valve body lower port cooperation place are taper seat; Described needle-valve spool is a hollow, and the inner surface of needle-valve spool bottom is provided with flange, is used for being slidingly matched with exhasut valve stem; Described needle-valve spool bottom also offers two radial holes, and these two radial holes lay respectively at the upside and the downside of flange; Described exhasut valve stem is inverted T-shaped, is sheathed on from the bottom to top in the described needle-valve spool, and the gap location between needle-valve spool and exhasut valve stem top is arranged with the compression spring, and the lower end of this compression spring is butted on the formed shoulder hole of flange; Be provided with O type rubber ring between the spacing end face of the following end in contact of the flange of this exhasut valve stem lower end and needle-valve spool; Described aerofluxus bonnet is by being threaded in the top of exhasut valve stem, and the centre of the lower surface of this aerofluxus bonnet offers the circular groove that is used to be nested with the compression spring, and the lower surface of this aerofluxus bonnet radially is provided with groove and is communicated with circular groove.
As another kind of improvement the of the present invention, the longitudinal section of the upper end of described needle-valve spool is H shape, and its upper surface is spacing as the step of aerofluxus bonnet.The radial groove in the lower surface of described aerofluxus bonnet is cross.
As another kind of improvement the of the present invention, the diameter of described counterweight 9 is than the big 1~3mm of diameter of piezoelectric ceramics sheet.The length of described rustless steel needle tubing 1 is 380~440mm.
As another kind of improvement the of the present invention, described piezoelectric ceramic piece 7 is more than two, accompanies electrode slice 22 between every adjacent two piezoelectric ceramic pieces.
As another kind of improvement the of the present invention, also be arranged with sleeve 8 between described shell 11 and the counterweight 9, this sleeve is the polyflon material, its two ends are connected with O type sealing ring.
As another kind of improvement the of the present invention, described horn adopts titanium alloy material; The external form of described horn is an exponential type curve, y=a * e Bx, wherein, 0≤x≤20.
As another improvement of the present invention, described Direct Digital synthesizer can be an integrated chip independently; Also can be integrated in the numerical portion of DDS and add the digital to analog converter realization in the field programmable logic device FPGA then.Wherein, the purpose of DDS controller mainly is the signal frequency of traffic rate change DDS output that can be very high, in the past to DDS (Direct Digital synthesizer, Dirrect Digital Synthesizer) control mainly realizes by microcontroller serial port, because the microcontroller serial port speed ratio is lower, do automatic frequency tracking and have communication performance bottleneck, poor effect with its control DDS.
As another improvement of the present invention, described phase-comparison circuit, utilize trigger the sensitivity characteristic of rising edge signal to be provided the time difference of the rising edge signal arrival of I_ph and two input signals of V_ph, and provide the sequencing that the rising edge of I_ph and two input signals of V_ph arrives by the Dirrect pin, as shown in Figure 5.
As another improvement of the present invention, the input signal of the controller of described Direct Digital synthesizer is 1 and triggers enabling signal, 32 frequency word signal, control word signal with 16, the content of serial communication mainly is that branch sends for three times, first 16 control words that send the Direct Digital synthesizer, second 16 and the 3rd 16 frequency words that send DDS are written into the Direct Digital synthesizer to 48 bit frequency words to change its output frequency automatically; The output signal of the controller of described Direct Digital synthesizer is adopted high speed three-wire type serial communication, and its serial ports is made up of data wire, clock line and line synchro, and when idle, data wire, line synchro, clock line are high level; During communication, line synchro is put low level, and valid data align with the clock trailing edge of clock line, sends line synchro after 16 bit data, data wire and clock line and all puts high level.
The Starting mode of described serial communication is the trailing edge triggering but can not heavily triggers, when system is idle, the triggering input of DDS controller just starts serial communication to the trailing edge of pulse whenever, when system is idle after serial communication is finished, run into the pulse trailing edge again and just can restart serial communication once more, and can not restart serial communication when during serial communication, running into the pulse trailing edge.
The phase difference signal of described phase-comparison circuit output is used to control the triggering enabling signal of DDS controller, and the error integrator of described phase comparator (being that module is accumulated in shown in Figure 3 differing) is used to export the frequency word signal of control DDS controller.
Ultrasonic transducer provided by the invention, owing to adopted high performance piezoceramic material, rational assembly technology, effectively reduced the impedance of ultrasonic transducer, the caloric value of ultrasonic transducer is significantly reduced, the inner suction stone conduit that adopts metal can more be taken away the heat that piezoelectric ceramics produces, and guarantees the isoparametric concordance of ultrasonic transducer frequency impedance in the use.Wherein,
Horn of the present invention adopts titanium alloy material, and it is to ultransonic conduction with to the amplification of amplitude, far above as other metal materials such as copper alloys.Horn among the present invention is to use the horn of the exponential curve profile of precise numerical control machine processing, and the existing good anti-mechanical fatigue performance of the horn of this profile can effectively raise the amplification of amplitude again.
The present invention is between shell and the core body be made up of counterweight, pottery, horn, the sleeve that has added poly-PTFE, the sleeve two ends are pressed with O type ring, and this structure can effectively reduce ultrasonic conduction to shell, and can significantly reduce the low-frequency vibration that inner vibrations are supervened.All the other core bodys and surgery and coupling part touch the O type ring that the silicone rubber material is also all adopted at the position, make whole energy transducer have higher mechanical quality factor, can smash harder calculus effectively.
Simultaneously, this ultrasonic transducer also has been equipped with trajectory rubble interface, can use mode ultrasonic and that trajectory combines to treat to the superhard calculus of super large, and this interface also is applicable to laser lithotripsy equipment such as holmium laser and neodymium laser.
In addition, another innovative point of the present invention is that the ultrasonic transducer handle rear end has been installed the Pressure Regulation Exhaust valve, solve the adjusting of adsorptive pressure in the art and be drawn onto the problem that soft tissue stops up needle tubing, injury human organ easily, make the rubble operation technique more convenient easily, also more safe and reliable.
Ultrasonic transducer automatic frequency tracking provided by the invention system adopts Direct Digital synthesizer (DDS) and field programmable gate function, it is characterized in that the pumping signal of ultrasonic transducer is produced by the Direct Digital synthesizer; The Direct Digital synthesizer can be an integrated chip independently, also can the numerical portion of DDS integrated with field programmable logic device FPGA in add digital to analog converter then and realize.With field programmable gate function design specialized phase comparator, this phase comparator forward position sensitivity to signal, and with the independent of duty cycle of signal, after there was the signal of time-delay in but forward position identical to two frequencies of phase comparator input, this phase comparator can produce output signal indication respective phase difference and direction thereof.
The present invention adopts the strategy of searching for earlier the automatic frequency tracking of afterwards following the tracks of, and first scanning search is then from motion tracking.Before ultrasonic transducer started excitation at every turn, the main control single-chip microcomputer carried out frequency sweep by DDS controller instruction DDS in preset range, and the amplitude of real time monitoring transducer current feedback is searched for resonance point simultaneously.In the time of near searching resonance point, stop frequency search also changes automatic tracking mode over to, at this moment adjusts the DDS output signal frequency by the DDS controller automatically according to the output result of phase comparator and follows the tracks of to realize automatic dynamic.
Compare with prior art, there are following characteristics in totally digitilized automatic frequency tracking method and the system thereof that is used to drive the novelty of ultrasonic transducer of the present invention:
1. adopt the automatic frequency tracking system design of DDS and field programmable gate function.
(1) pumping signal of ultrasonic transducer is produced by the Direct Digital synthesizer among the present invention, adopts the traditional phaselocked loop and the scheme of voltage controlled oscillator in the design different from the past; Direct Digital synthesizer (DDS) can be a chip independently among the present invention, also can be integrated in the numerical portion of DDS in the field programmable logic device FPGA, adds digital to analog converter then and constitutes Direct Digital synthesizer (DDS) on the function.This implementation can be with reference to figure 4.
(2) make digitized processing with field programmable gate function design specialized phase comparator, and to phase signal.Phase-comparison circuit only is characterised in that the forward position sensitivity to signal, and with the independent of duty cycle of signal, after there was the signal of time-delay in but forward position identical to two frequencies of phase comparator input, this phase-comparison circuit can produce output signal indication respective phase difference and direction thereof.
(3) with field programmable gate function design specialized high-speed DDS controller, thereby this controller is controlled the real-time automatic tracking of the output frequency realization transducer resonance point of DDS at any time according to the output result of phase comparator.
2. search for earlier the automatic frequency tracking system design of afterwards following the tracks of.
Because the difference of manufacturing process and the influence of various inside and outside factors, the initial resonance point of transducer has certain discreteness.For guarantee in the start-up course reliable, follow the tracks of fast, the native system design adopts first scanning search then from the strategy of motion tracking.
(1) before ultrasonic transducer starts excitation at every turn, master controller carries out frequency sweep by DDS controller instruction DDS in preset range, and the amplitude of real time monitoring transducer current feedback is searched for resonance point simultaneously;
(2) in the time of near searching resonance point, stop frequency search also changes automatic tracking mode over to, realizes that automatic dynamic follows the tracks of thereby at this moment adjust the DDS output signal frequency by the DDS controller automatically according to the output result of phase-comparison circuit.
The invention has the advantages that:
Ultrasonic transducer provided by the invention, owing to adopted high performance piezoceramic material, rational assembly technology, effectively reduced the impedance of transducer, the caloric value of transducer is significantly reduced, the inner suction stone conduit that adopts metal can more be taken away the heat that piezoelectric ceramics produces, and guarantees the isoparametric concordance of transducer frequency impedance in the use.Simultaneously, adopt the horn of the exponential curve profile of precise numerical control machine processing, effectively raise the amplification of amplitude, the O type ring of silicone rubber material is all adopted in the connection of node and contact site, make whole energy transducer have higher mechanical quality factor, can smash harder calculus effectively.
Simultaneously, this ultrasonic transducer also has been equipped with trajectory rubble interface, can use mode ultrasonic and that trajectory combines to treat to the superhard calculus of super large, and this interface also is applicable to laser lithotripsy equipment such as holmium laser and neodymium laser.In addition, the Pressure Regulation Exhaust valve has been installed in the transducer handle rear end, has solved the calculus of the different sizes of absorption and has been drawn onto the problem that soft tissue stops up needle tubing easily, makes the rubble operation technique more convenient easily, also more safe and reliable.
Ultrasonic transducer automatic frequency tracking provided by the invention system as signal source, has replaced common analog vco with Direct Digital Frequency Synthesizers, has realized digital control.The dedicated phase comparator and the DDS controller that adopt the field programmable gate function design to realize, Highgrade integration, operating rate is fast, and is reliable and stable.System's control accuracy height, tracking velocity are fast, under the certain situation of the dynamic characteristic of the resolution of DDS and the programming device that adopted, can adjust the frequency resolution and the control accuracy of change system by programming.Follow the tracks of response speed and depend on the system works clock, its upper limit depends on the high operation speed (clock) of DDS and programming device.Simultaneously, owing to adopted frequency sweep-tracking strategy, can adapt to the bigger situations of condition difference such as transducer and load thereof, and in case can recover automatically when finding miss tracking, make the whole system adaptability good, follow the tracks of reliable.
In a word, the automatic frequency tracking solution of total digitalization of the present invention, its output frequency and frequency word strictness are the linear changing relation, and tracking accuracy can be set fully according to actual needs, and has designed special-purpose high-speed DDS controller and brand-new phase comparator.Control to DDS in the past mainly realizes by microcontroller serial port, because the microcontroller serial port speed ratio is lower, do automatic frequency tracking and have communication performance bottleneck with its control DDS, poor effect, and the serial communication speed of the high-speed DDS controller that we design reaches as high as 40M, solve the communication performance bottleneck problem for a full due, be enough to satisfy the requirement of automatic frequency tracking.In addition, the brand-new phase comparator of our design only to the rising edge of two input signals responsive and and independent of duty cycle.We have also done digitized processing to the phase signal of phase comparator output in addition, and this has just fundamentally improved the precision of frequency-tracking greatly, thereby the motor conversion efficiency of transducer is improved greatly.Make the bigger different transducers of individual variation to realize automatic frequency tracking with the control circuit of same electrical quantity by searching for earlier the processing policy of afterwards following the tracks of in addition, this is very beneficial for large-scale industrial production.
Description of drawings
Fig. 1 is the interior ultrasonic rubble transducer architecture sketch map of the body of R-Wolf company in the prior art;
Fig. 2 is a ultrasonic transducer structural representation of the present invention;
Fig. 3 is the cut-away view of Fig. 2 along the transducer cable lead portion of B-B line;
Fig. 4 is the cut-away view of Fig. 2 along the transducer radial direction through hole of A-A line;
Fig. 5 is the structure cut-away view of Pressure Regulation Exhaust valve of the present invention;
Fig. 6 is the three-dimensional exploded view of the structure of Pressure Regulation Exhaust valve of the present invention;
The structural representation of the needle-valve spool of Fig. 7 a~d Pressure Regulation Exhaust valve of the present invention;
The structural representation of the aerofluxus bonnet of Fig. 8 a~d Pressure Regulation Exhaust valve of the present invention;
Fig. 9 is the solution based on the CPLD device of the present invention;
Figure 10 is a DDS controller flow chart of the present invention;
Figure 11 is the accumulation module diagram that differs of the present invention;
Figure 12 is the solution based on the FPGA device of the present invention;
Figure 13 is the logic chart of phase comparator of the present invention.
The accompanying drawing sign
1, rustless steel needle tubing 2, union joint 3, union joint O type ring
4, elastic tube 5, horn 6, horn O type ring
7, piezoelectric ceramic piece 8, sleeve 9, counterweight
10, hold-down bolt 11, shell 12, sleeve O type ring
13, Pressure Regulation Exhaust valve 14, sealing gasket 15, bonnet
16, gas-tpe fitting O type ring 17, gas-tpe fitting 18, adapter
19, hold-down bolt O type ring 20, suction stone conduit 21, insulated sleeve
22, electrode slice 23, cone medicated cap
24, lead 25, conductor interface medicated cap 26, conductor interface seat
131, needle-valve spool 132, needle valve body 133, tee pipe coupling
134, aerofluxus bonnet 135, compression spring 136, exhasut valve stem
137, exhaust valve 138, sealing O type circle
The specific embodiment
Ultrasonic transducer of the present invention, shown in Fig. 2~4, constitute by rustless steel needle tubing 1, union joint 2, union joint O type ring 3, elastic tube 4, horn 5, horn O type ring 6, piezoelectric ceramic piece 7, sleeve 8, counterweight 9, hold-down bolt 10, shell 11, sleeve O type ring 12, Pressure Regulation Exhaust valve 13, sealing gasket 14, bonnet 15, gas-tpe fitting O type ring 16, gas-tpe fitting 17, adapter 18, hold-down bolt O type ring 19, suction stone conduit 20, insulated sleeve 21, electrode slice 22, cone medicated cap 23, lead 24, conductor interface medicated cap 25 and conductor interface seat 26.
Wherein, described rustless steel needle tubing 1 is the elongated stainless steel tube of hollow, union joint 2 is that an end is that conical, the other end is that cylindrical, cylinder has screw thread, integral shaft to the structure that a manhole is arranged, in conical end and rustless steel needle tubing 1 coaxial welding together, be connected by the external screw thread of cylindrical end and the female thread of horn 5 awl ends, elastic tube 4 is in the inside of horn 5, be clipped between union joint 2 and the suction stone conduit 20, wherein elastic tube 4 is the polytetrafluoroethylplastic plastic pipe, and inhaling stone conduit 20 is thin-wall stainless steel; Described piezoelectric ceramic piece 7 can be more than two or two, accompany electrode slice 22 between per two, horn 5 and counterweight 9 are clipped in the middle piezoelectric ceramic piece 7, hold-down bolt 10 passes counterweight 9, piezoelectric ceramic piece 7 and electrode slice 22, be connected with horn 5, hold-down bolt 10 axially is a through hole, inhaling stone conduit 20 passes wherein, insert the axial through hole of adapter 18, be pressed with hold-down bolt O type ring 19 between hold-down bolt 10 and the adapter 18, the part that hold-down bolt 10 passes piezoelectric ceramic piece 7 and electrode slice 22 is with insulated sleeve 21; Described adapter 18 is the four-way structure, radial two holes connect Pressure Regulation Exhaust valve 13 and gas-tpe fitting 17 respectively, wherein the junction with gas-tpe fitting 17 is pressed with gas-tpe fitting O type ring 16, axial forward end connects inhales stone conduit 20, the rear end bonnet 15 that has been threaded is pressed with sealing gasket 14 between the two; Shell 11 and cone medicated cap 23 are for being threaded, be lined with union joint O type ring 3 between cone medicated cap 23 awl end inside and the horn 5 awl end outsides, cone medicated cap 23 is the inner and bigger end of horn 5 diameters outside than larger diameter end, the position at whole energy transducer node place just, between be pressed with horn O type ring 6, sleeve 8 is enclosed between shell 11 and the counterweight 9, and is pressed with sleeve O type ring 12 between the adapter 18, and the other end contacts with horn O type ring 6 pressure.
In above-mentioned technical scheme, the operating frequency of described transducer is 23~28kHz; The amplification of described horn is about 10~16 times; The terminal amplitude of described rustless steel needle tubing is 40~100um; Shell is the fire resistant resin material, and sleeve is the polyflon material, and the O type ring at two ends is a silastic material, and the three guarantees the piezoelectric ceramics that it is inner and the insulation and the sealing of electrode slice and external shell; Whole device promptly can fumigation under 125 degrees celsius, also can be in disinfectant solution under the normal pressure soaking disinfection.
In this example, piezoelectric ceramic piece 7 is two, accompany electrode slice 22 between two, horn 5 and counterweight 9 are clipped in the middle piezoelectric ceramic piece 7 and electrode slice 22, hold-down bolt 10 passes counterweight 9, piezoelectric ceramic piece 7 and electrode slice 22, is connected with horn 5, and on the contact surface of horn 5, counterweight 9, piezoelectric ceramic piece 7 and electrode slice 22 etc., all scribble coupling glue, after hold-down bolt 10 compresses, can obtain lower impedance and suitable frequency.Hold-down bolt 10 axially is a through hole, inhales stone conduit 20 and passes wherein, inserts the axial through hole of adapter 18, and the part that hold-down bolt 10 passes piezoelectric ceramic piece 7 and electrode slice 22 is with insulated sleeve 21.Adapter 18 is the four-way structure, and radial two holes connect Pressure Regulation Exhaust valve 13 and gas-tpe fitting 17 respectively, and wherein the junction with gas-tpe fitting 17 is pressed with gas-tpe fitting O type ring 16, and the rear end bonnet 15 that has been threaded is pressed with sealing gasket 14 between the two; After bonnet 15 and sealing gasket 14 took off, adapter 18 can connect corresponding air pressure trajectory or laser lithotripsy device.Rustless steel needle tubing 1 is in the same place with union joint 2 coaxial welding, be connected by the female thread of the external screw thread on the union joint 2 with horn 5 awl ends, elastic tube 4 is in the inside of horn 5, be clipped between union joint 2 and the suction stone conduit 20, shell 11 and cone medicated cap 23 are for being threaded, be lined with union joint O type ring 3 between cone medicated cap 23 awl end inside and the horn 5 awl end outsides, cone medicated cap 23 is the inner and bigger end of horn 5 diameters outside than larger diameter end, the position at whole energy transducer node place just, between be pressed with horn O type ring 6, sleeve 8 is enclosed between shell 11 and the counterweight 9, and is pressed with sleeve O type ring 12 between the adapter 18, and the other end contacts with horn O type ring 6 pressure.
The present invention also provides a kind of barometric control unit-Pressure Regulation Exhaust valve that is used on the gas piping, combinative structure by a kind of adjust blood pressure needle-valve and rapid escape valve, overcome singlehanded difficulty of operating adjust blood pressure needle-valve and air bleeding valve simultaneously, be used for the adjust blood pressure and the aerofluxus fast of vacuum suction pipeline.
Shown in Fig. 5~8, described Pressure Regulation Exhaust valve is by O type rubber ring 138, exhasut valve stem 136, needle-valve spool 131, needle valve body 132, aerofluxus bonnet 134 and compression spring 135 are formed, exhasut valve stem 136 and aerofluxus bonnet 134 are by being threaded, compression spring 135 is enclosed within on the exhasut valve stem 136, pass the endoporus of needle-valve spool 131, O type rubber ring is arranged between exhasut valve stem 136 and the needle-valve spool 131, needle-valve spool 131 and needle valve body 132 are directly by being threaded, the cooperation place, lower end is a taper seat, needle valve body 132 outer surfaces are useful on and the extraneous screw thread of installing, and an end of needle valve body 132 is with O type rubber ring 138.An axial shoulder hole is arranged, two radial holes on the needle-valve spool 131.And have a following characteristics: 1, keep sealing with O type rubber ring between exhasut valve stem 136 and the needle-valve spool 131, needle valve body 132 and extraneous pipeline guarantee to seal by compressing O type rubber ring 138 by being threaded.Keep sealing by O type rubber ring 138 between needle-valve spool 131 and spacing end face that exhasut valve stem 136 contacts.2, all parts are assemblied on the same axis.3, needle-valve spool 1 axially has a shoulder hole, and exhasut valve stem 136 is by this shoulder hole, in the aperture less place both radially slide cooperation, and have step spacing at end face.4, needle-valve spool 131 has two radial holes, gas was from the gap between needle-valve spool 131 and the needle valve body 132 when system's malleation was regulated, radial hole on needle-valve spool 131 flows out by shoulder hole axial on the needle-valve spool 131 again, and is opposite when gas flow was with malleation when system's negative pressure was regulated.
The top of needle valve body of the present invention and needle-valve spool is to be threaded, counterclockwise turn needle-valve spool when using, can separate relatively in the axial direction between the two, the conical surface place of lower end forms annular gap, the distance decision that the size in gap is axially separated by both, the so just adjusting of the pressure of realizing; The needle-valve spool serves as the effect of rapid escape valve body simultaneously.Its advantage is that the total of barometric control unit is installed on the vacuum suction pipeline by the screw thread on the needle valve body, guarantees sealing with O type rubber ring.When needs are regulated pipeline air pressure, turn needle-valve spool, needle-valve is opened, and ambient atmos enters pipeline via two radial holes on the needle-valve spool; When the quick aerofluxus of needs, press the aerofluxus bonnet, drive exhasut valve stem, make O type rubber ring leave the lower surface of needle-valve spool, realize quick aerofluxus, unclamp the aerofluxus bonnet, under the effect of compression spring, the moving exhasut valve stem of air bleeding valve hatband resets; And the present invention is simple in structure, compact, is easy to processing, cleaning for convenience detach, and the Pressure Regulation Exhaust action is singlehanded just can be realized.
Design of the present invention has the principle of same phase based on the driving voltage and the electric current of ultrasonic transducer at its resonant frequency point, adopt contemporary state-of-the-art Direct Digital to synthesize (DDS) and field programmable gate function, realized a kind of totally digitilized automatic frequency tracking scheme of novelty.
Concrete totally digitilized characteristic mainly shows:
1. the DDS as the transducer excitation source adopts digital serial communication mode control.
The phase difference signal that phase comparator provides is done to have fed back to DDS to realize frequency-tracking, as shown in figure 11 after the digitized calculation process.
Core technology of the present invention mainly is DDS controller F and only to the design of the phase comparator E of signal edge sensitive.The program flow diagram of DDS controller F, as shown in figure 10.
The general frame of the present invention, as shown in Figure 9, concrete work process is as follows:
(1) Direct Digital synthesizer (DDS) A produces the sine wave signal of a certain frequency, power amplifier B with its amplification after matching network drives ultrasonic transducer I;
(2) sampling loop C obtains one group of voltage and current feedback signal of transducer I from power take-off, and this group signal is delivered to phase-comparison circuit E and delivered to main control singlechip G through amplitude adjusting circuit H through filtering shaping circuit D respectively;
(3) main control singlechip G sends the cline frequency scan instruction to DDS controller F, make the sine wave of DDS A output different frequency in predetermined frequency range scan, main control singlechip G monitors the sampling current feedback signal simultaneously, is close to the resonant frequency point of transducer up to search;
(4) after search rate is close to the resonance point of transducer, stop search, main control singlechip G sends automatic trace command to DDS controller F, and DDS controller F begins resonant frequency from the motion tracking transducer from this Frequency point;
(5) phase-comparison circuit E is to carrying out the phase bit comparison from transducer I and the voltage and current feedback signal after filtering shaping circuit D handles, then phase difference signal is inputed to and differ summation circuit L to produce the frequency word of DDS, DDS controller F can pass to DDS chip A to frequency word changing straight its output signal frequency with the speed of 40M, thereby makes ultrasonic transducer I always work near the resonance point.
As shown in figure 12, a kind of form of distortion of the present invention promptly adopts the FPGA device to realize automatic frequency tracking.The main distinction of it and method noted earlier is as follows:
(1) numerical portion of DDS is integrated in the fpga chip, and the simulation part realizes by a digital to analog converter that adds.
(2) the said DDS controller in DDS control logic F and front also is distinguishing, and the DDS control logic is here mainly determined by the DDS control interface of programmer design.

Claims (16)

1. ultrasound lithotripter in the body comprises it is characterized in that the automatic frequency tracking system of ultrasonic transducer and ultrasonic transducer,
Described ultrasonic transducer comprises: rustless steel needle tubing (1), union joint (2), union joint O type sealing ring (3), elastic tube (4), horn (5), horn O type sealing ring (6), piezoelectric ceramic piece (7), counterweight (9), hold-down bolt (10), shell (11), gas-tpe fitting O type sealing ring (16), gas-tpe fitting (17), hold-down bolt O type sealing ring (19), inhale stone conduit (20), insulated sleeve (21), electrode slice (22), cone medicated cap (23), lead (24), conductor interface medicated cap (25) and conductor interface seat (26);
The conductor interface seat (26) on described shell (11) top and on conductor interface medicated cap (25), be located at the position of departing from shell (11) axis;
The top that is positioned at hold-down bolt (10) in the described shell (11) also includes adapter (18), this adapter (18) corresponding to conductor interface seat (26) and on conductor interface medicated cap (25), be axially arranged with peripheral through hole in the position of departing from shell (11) axis along being parallel to shell (11), its upper end is communicated with conductor interface seat (26), is used to hold lead; Described adapter (18) is the four-way structure, and the front end of the central through hole that it is axial is communicated with inhales stone conduit (20), and the rear end of this central through hole is fixedly connected on the top of shell (11); Described adapter (18) departs from peripheral through hole and radially offers two radial direction through hole, is respectively applied for to be communicated with Pressure Regulation Exhaust valve (13) and gas-tpe fitting (17), and the junction of gas-tpe fitting (17) and adapter (18) is pressed with gas-tpe fitting O type sealing ring (16);
The automatic frequency tracking system of described ultrasonic transducer as signal source, adopts frequency sweep one tracking strategy with the Direct Digital synthesizer, realizes the automatic frequency tracking of total digitalization, comprising:
One direct digital synthesizer is used to produce the sine wave signal of frequency adjustable, and after power amplifier amplifies, drives ultrasonic transducer with matching network;
One sampling loop is used for obtaining from the power take-off of ultrasonic transducer one group of voltage and current feedback signal of ultrasonic transducer, and this group signal is delivered to phase-comparison circuit, delivered to main control singlechip through amplitude adjusting circuit through filtering shaping circuit respectively;
One main control singlechip, main control singlechip is according to the triggering signal and the frequency word of the controller of the operating frequency range control Direct Digital synthesizer of predetermined ultrasonic transducer itself, and the controller of Direct Digital synthesizer sent the cline frequency scan instruction, make the controller output frequency continually varying sine wave of Direct Digital synthesizer; Simultaneously, described main control singlechip is the amplitude of the sampling current feedback signal of real time monitoring ultrasonic transducer also, half when the amplitude of the current feedback signal current amplitude during greater than ultrasonic transducer resonance, the frequency word that shows main control singlechip is basically near the resonant frequency point of ultrasonic transducer the time, main control singlechip will allow the controller of Direct Digital synthesizer stop frequency sweep, sends automatic trace command;
One phase-comparison circuit, be used for the voltage and current feedback signal after handling through filtering shaping circuit is carried out the phase bit comparison, and phase difference signal inputed to differ summation circuit to produce the frequency word of Direct Digital chip combiner, by Direct Digital synthesizer controller this frequency word is passed to the Direct Digital chip combiner to change its output signal frequency automatically, thereby make ultrasonic transducer always work near the resonance point, realize automatic frequency tracking.
2. ultrasound lithotripter in the body according to claim 1 is characterized in that the rear end of described central through hole connects corresponding air pressure trajectory or laser lithotripsy device; Or the bonnet that has been threaded (15), and between rear end and bonnet, be pressed with sealing gasket (14).
3. ultrasound lithotripter in the body according to claim 1 is characterized in that, described Pressure Regulation Exhaust valve (13) comprises needle valve body, needle-valve spool, exhasut valve stem, aerofluxus bonnet, compression spring and the O type rubber ring of coaxial setting;
Described needle valve body is cylindrical, and its outer surface is provided with and is used for the screw thread that is connected with tee T on the extraneous gas piping; The lower end of this needle valve body is arranged with O type rubber ring, by compressing the sealing between this O type rubber ring assurance needle valve body and the tee T;
Described needle-valve spool is roughly T-shaped, from top to bottom is sheathed in the described needle valve body; The outer surface on described needle-valve spool top and the upper inside surface of described needle valve body are threaded, leave the gap between the outer surface of described needle-valve spool bottom and the lower inner surface of described needle valve body, described needle-valve spool and described needle valve body lower port cooperation place are taper seat; Described needle-valve spool is a hollow, and the inner surface of needle-valve spool bottom is provided with flange, is used for being slidingly matched with exhasut valve stem; Described needle-valve spool bottom also offers two radial holes, and these two radial holes lay respectively at the upside and the downside of flange;
Described exhasut valve stem is inverted T-shaped, is sheathed on from the bottom to top in the described needle-valve spool, and the gap location between needle-valve spool and exhasut valve stem top is arranged with the compression spring, and the lower end of this compression spring is butted on the formed shoulder hole of flange; Be provided with O type rubber ring between the spacing end face of the following end in contact of the flange of this exhasut valve stem lower end and needle-valve spool;
Described aerofluxus bonnet is by being threaded in the top of exhasut valve stem, and the centre of the lower surface of this aerofluxus bonnet offers the circular groove that is used to be nested with the compression spring, and the lower surface of this aerofluxus bonnet radially is provided with groove and is communicated with circular groove.
4. ultrasound lithotripter in the body according to claim 3 is characterized in that the longitudinal section of the upper end of described needle-valve spool is H shape, and its upper surface is spacing as the step of aerofluxus bonnet.
5. according to ultrasound lithotripter in claim 3 or the 4 described bodies, it is characterized in that the radial groove in the lower surface of described aerofluxus bonnet is cross.
6. ultrasound lithotripter in the body according to claim 1 is characterized in that the diameter of described counterweight (9) is than the big 1~3mm of diameter of piezoelectric ceramics sheet.
7. ultrasound lithotripter in the body according to claim 1 is characterized in that the length of described rustless steel needle tubing (1) is 380~440mm.
8. ultrasound lithotripter in the body according to claim 1 is characterized in that described piezoelectric ceramic piece (7) is more than two, accompanies electrode slice (22) between every adjacent two piezoelectric ceramic pieces.
9. ultrasound lithotripter in the body according to claim 1 is characterized in that also be arranged with sleeve (8) between described shell (11) and the counterweight (9), this sleeve is the polyflon material, and its two ends are connected with O type sealing ring.
10. ultrasound lithotripter in the body according to claim 1 is characterized in that, described horn adopts titanium alloy material.
11. ultrasound lithotripter in the body according to claim 1 is characterized in that the external form of described horn is an exponential type curve, y=a * e Bx, 0≤x≤20 wherein.
12. ultrasound lithotripter in the body according to claim 1 is characterized in that, described Direct Digital synthesizer is an integrated chip independently; Perhaps the numerical portion of Direct Digital synthesizer is integrated in and adds the digital to analog converter realization in the field programmable logic device then.
13. ultrasound lithotripter in the body according to claim 1, it is characterized in that, described phase-comparison circuit utilizes trigger that the sensitivity characteristic of rising edge signal is provided the time difference of the rising edge signal arrival of I_ph and two input signals of V_ph, and is provided the sequencing of the rising edge arrival of I_ph and two input signals of V_ph by the Dirrect pin.
14. ultrasound lithotripter in the body according to claim 1, it is characterized in that, the input signal of described Direct Digital synthesizer controller is 1 and triggers enabling signal, 32 frequency word signal, control word signal with 16, the content of serial communication mainly is that branch sends for three times, first 16 control words that send the Direct Digital synthesizer, second 16 and the 3rd 16 frequency words that send the Direct Digital synthesizer are written into the Direct Digital synthesizer to 48 bit frequency words to change its output frequency automatically;
The output signal of described Direct Digital synthesizer controller adopts high speed three-wire type serial communication, and its serial ports is made up of data wire, clock line and line synchro, and when idle, data wire, line synchro, clock line are high level; During communication, line synchro is put low level, and valid data align with the clock trailing edge of clock line, sends line synchro after 16 bit data, data wire and clock line and all puts high level.
15. ultrasound lithotripter in the body according to claim 14, it is characterized in that, the Starting mode of described serial communication is the trailing edge triggering but can not heavily triggers, when system is idle, the triggering input of Direct Digital synthesizer controller just starts serial communication to the trailing edge of pulse whenever, when system is idle after serial communication is finished, run into the pulse trailing edge again and just can restart serial communication once more, and can not restart serial communication when during serial communication, running into the pulse trailing edge.
16. ultrasound lithotripter in the body according to claim 1, it is characterized in that, the phase difference signal of described phase-comparison circuit output is used to control the triggering enabling signal of Direct Digital synthesizer controller, and the error integrator of described phase-comparison circuit is used to export the frequency word signal of control Direct Digital synthesizer controller.
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Address before: 100176 Daxing District Beijing economic and Technological Development Zone, Kangding street, No. 11, building No. 20

Patentee before: Beijing 3H Medical Technology Co., Ltd.

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Address after: Two street 100176 Beijing economic and Technological Development Zone in 8 Hospital No. 18 building 3 layer 4 layer 5 layer 504-520 room

Patentee after: Beijing 3H Medical Technology Co., Ltd.

Address before: 100176 Daxing District Beijing economic and Technological Development Zone, Kangding street, No. 11, building No. 20

Patentee before: Beijing 3H Medical Technology Co., Ltd.

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Effective date of registration: 20210610

Address after: 100176 2nd floor, building 18, yard 8, Liangshuihe 2nd Street, Beijing Economic and Technological Development Zone, Daxing District, Beijing

Patentee after: BEIJING ANHEJIABAOER TECHNOLOGY Co.,Ltd.

Address before: 100176 room 504-520, 3 / F, 4 / F, 5 / F, building 18, yard 8, Liangshuihe Second Street, Beijing Economic and Technological Development Zone

Patentee before: BEIJING 3H MEDICAL TECHNOLOGY Co.,Ltd.