CN101600470A - 具有支架状锚的神经刺激导线 - Google Patents
具有支架状锚的神经刺激导线 Download PDFInfo
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Abstract
描述了具有支架状锚的神经刺激导线。所述导线的远侧部安装至导线锚外部。所述支架状的导线锚由超弹性材料形成,并且适于在血管中展开时从收缩形态转换至膨胀形态。膨胀形态中,所述导线锚将所述导线按压抵靠在其中展开的血管的至少一个血管壁,从而固定及稳定所述血管内的所述导线的远侧部。
Description
技术领域
本发明涉及用于神经或肌肉刺激的医用电导线及其结构。本发明尤其涉及使得导线稳定在邻近待刺激神经的血管内位置的医用电导线结构。
背景技术
现今已对包括左右迷走神经、交感神经和副交感神经、膈神经、骶神经及海绵体神经在内的多种神经的直接或非直接刺激有了相当多的研究,以治疗多种医学、精神病学及神经学上的失调或病症。最近,已提出将迷走神经的刺激作为对多种包括心衰在内的多种心脏疾病的治疗方法。
过去,神经刺激电极一般套在待刺激神经上与之直接接触。很少采用创伤法来使用血管内导线经由邻近的静脉来刺激神经。包括一或多个电极的导线插入患者的脉管系统并且被传递至邻近待刺激神经的血管内的位置。然而,在静脉内没有用于稳定导线的其他装置的情况下,导线会移动及/或旋转,导致电极离开刺激位置。
由此,需要开发一种使导线移动和旋转最小化,并且能够可靠进行长期治疗机构。
发明内容
根据本发明的一实施例,一种用于刺激神经的医用电导线,所述导线包括:导电的导线体,其具有适于连接至脉冲生成器的近侧端;包括至少一个电极的远侧部,所述电极适于穿过血管壁传递电脉冲;及导线锚。所述导线锚适于从收缩形态膨胀至预形成的膨胀形态,其中,在所述膨胀形态中,所述远侧部的有效长度基本等于收缩的所述导线锚的有效长度。所述远侧部这样连接至所述导线锚的外部,即在所述膨胀形态中所述导线锚将所述导线的所述远侧部按压抵靠在所述导线在其中展开的血管的至少一个管壁,从而固定及稳定所述血管内的所述导线的远侧部。
根据本发明的另一实施例,一种从相邻血管内部刺激神经的医用电导线包括:适于连接至脉冲生成器的近侧端;包括至少一个电极的远侧部,所述电极适于穿过血管壁传递电脉冲;及适于从收缩形态膨胀至预形成的膨胀形态的导线锚。所述远侧部连接至所述导线锚的外部。
根据本发明的另一实施例,一种用于固定及稳定血管内导线的导线锚组件,所述导线锚组件包括导线锚,所述导线锚包括固定至导线体的第一端以及多个从所述固定于导线体的第一端延伸至第二端的、一体形成的支撑柱。所述导线锚可以由超弹性材料的激光切割管制成。
还描述了一种在相邻血管内部刺激神经的方法。根据本发明的一实施例,该方法包括设置包括导线锚组件的医用电导线。所述导线的远侧部安装至所述锚的外部。所述导线锚包括至少一个固定至导线的第一端以及多个从所述第一端延伸至第二端的柱杆,并且所述导线锚适于从收缩形态膨胀至预形成的膨胀形态,从而将所述导线的远侧部向上按压抵靠着所述血管的壁。此外,所述方法包括使得所述导线通过患者的脉管系统前进至所述血管内的刺激位置;部分地展开所述导线锚组件以使所述至少一个电极暴露;使用所述部分展开的导线锚组件暂时刺激所述神经;并且判定最优刺激阈值。所述方法还包括完全展开所述导线锚组件并且从所述血管内的刺激位置对相邻的神经进行长期刺激。
尽管业已揭露了多个实施例,本技术领域的技术人员通过下文描述本发明示范实施例的详细描述可清楚本发明的其它实施例。因此,这些附图和详述应认为是说明性的而非用于限制。
附图说明
图1和2为根据本发明一实施例的、展开在患者的颈内静脉中靠近迷走神经的位置的导线的示意图;
图3A~3D为根据本发明多个实施例的、包括导线锚的导线的远侧部的示意图,所述导线锚包括布置在血管中的锥形近侧端和远侧端;
图4A~4C为根据本发明多个实施例的、包括导线锚的导线的远侧部的示意图,所述导线锚包括布置在血管中的单个锥形端;
图5A~5C为根据本发明实施例的、在血管内传递和展开期间的包括导线锚的导线的局部剖视图。
尽管可将本发明修改为多种变化和代替形式,下文通过附图中的例子示出并且详细描述了具体实施方式。然而,本发明并不限于所描述的具体实施方式。相反,本发明意欲覆盖所有落入所附权利要求范围内的修改、等同物及替换。
具体实施方式
尽管本文描述的实施例主要涉及通过左或右锁骨下静脉将导线放入右颈内静脉,下文所述的本发明的多种实施例可在患者脉管系统内的多个位置进行。任何有可能从刺激获益的神经、肌肉或脑组织附近的血管内位置为刺激的可能位置。术语“血管”包括循环系统的所有静脉和动脉。此外,该术语“血管”包括淋巴系统的多种结构,包括淋巴结、淋巴管、毛细淋巴管、淋巴道。类似地,如文中所用的,该术语“血管”还包括肠胃系统的多种管状结构。在此使用的表述“神经”或“神经纤维”包括单神经元、神经、神经末梢,或神经束。术语“血管内”表示在静脉或动脉循环系统之内,包括各种类型和种类的血管。当在本发明实施例的描述中称为“血管内刺激”时,系指来自循环系统内部的、导致受益神经、肌肉或组织的(经血管的)刺激的刺激。术语“经血管的”系指穿过血管或血管壁。“刺激”系指通常为电的刺激,这一刺激导致例如通过流入细胞的钙和钠、或者细胞两端膜电位变化测得的一个细胞或多个细胞或一个细胞的一部分的去极化、收缩、激励。
已知其相邻处或附近有神经延伸的、直径足够让导管进入的血管可作为合适的候选可能刺激位置。位置的例子包括但不限于:左右颈内静脉、奇静脉、头臂(无名)静脉、锁骨下静脉、上腔静脉、肺动脉、心脏支血管。其它可能的刺激位置包括但不限于:胸导管、胆管、沿上胃肠道及下胃肠道的位置。待刺激神经的例子包括但不限于左右迷走神经、膈神经、副交感神经、交感神经及骶神经。
图1示出了患者的脉管系统2的立体图,导线6展开在系统2中。图2为展开在系统2中的导线6的放大示意图。一般地,如图所示,脉管系统2包括右颈外静脉10和左颈外静脉14、右颈内静脉18和左颈内静脉22、右锁骨下静脉26和左锁骨下静脉30,这些血管的一部分与右迷走神经34和左迷走神经38大致对齐。如图1和2所示,导线6通过左锁骨下静脉30插入患者的脉管系统,并且插入右颈内静脉18。导线6定位在靠近右迷走神经34的右颈内静脉18中。或者,导线6可经由右锁骨下静脉26插入并前进至右颈内静脉18中的刺激位置。
导线6包括具有近侧端和远侧部50的导线体42。一个或多个电极56沿导线体42设置,具体地,电极56位于导线6的远侧部50。该导线的近侧端适于与脉冲生成器或其它可植入医疗装置连接。导线体42为挠性,且其截面形状一般为圆形。
根据本发明的一实施例,导线体42包括多个传导件,所述传导件包括线、线圈、线缆。这些传导件可经绝缘处理与诸如硅、聚氨酯、乙烯四氟乙烯之类的绝缘体或其它生物相容绝缘聚合物在适当位置成型在一起。在本发明的一实施例中,导线体42为共径(co-radial)的设计。这一实施例中,各单独的传导件单独进行绝缘处理,然后将这些绝缘线圈平行卷绕在一起以形成单个的线圈。在另一实施例中,导线体42为共轴。根据本发明的再一实施例,各传导件适于以“一对一(one-to-one)”的方式连接至单个电极56,以使得可对各电极56进行独立的编址。本方面的另一实施例中,导线体42包括适于容纳导丝、或通管丝之类导向件的内腔。
导线6还包括远侧部50。远侧部50的构造可与导线体42相同或不同。根据本发明的一实施例,导线6的远侧部50的刚性大于导线体42。名称为“具有近侧张力减缓的经血管导线”的、经共同转让的第11/669,039号美国共同未决专利申请揭露了这一结构的示范实施例,通过引用将其合并在此。根据本发明的另一实施例,远侧部50包括这样的材料,即使得该远侧部50具有可将导线6的远侧部50锚定或固定在血管中。该材料的例子包括镍钛诺和其它本领域公知的材料。
远侧部50包括导线锚60。如图3A~4C所示,导线6的远侧部50安装至导线锚60的外部64。远侧部50使用包括粘合、焊接、缝合等多种方法将远侧部50结合至导线锚60。
远侧部50这样安装至导线锚60,即其随着形成锚60的柱杆的曲率延伸,如图3A、3C、4A和4B所示。或者,远侧部50可这样安装,即其沿着锚60的长度基本笔直地延伸,如图3B和4C所示。根据本发明的另一实施例,导线6的远侧部50这样安装至导线锚60的外部64,即导线6的远侧部50的第一端68与第二端72大致对齐(如图3A~3C所示)。更具体地,这些实施例中,导线的远侧部50这样安装至导线锚60的外部64,即第一端68与第二端72径向对齐。或者,导线6的远侧部50这样安装至导线锚60的外部64,即导线6的远侧部50的第一端68径向偏离第二端72,如图3D所示。
根据另一示范实施例,远侧部50分叉。分叉的远侧部50包括第一细长部件和第二细长部件。分叉远侧部的各细长部件安装至导线锚60的外部。各细长部件可随着形成锚60的柱杆的曲率延伸。或者,可这样安装细长部件,即这些细长部件沿着锚的长度大致笔直地延伸。根据再一实施例,其中一个细长部件随着柱杆延伸而另一个细长部件安装为沿锚60的长度大致笔直地延伸。
根据本发明的另一实施例,远侧部50可包括一个或多个在导线体42的外层中的凹陷。这些凹陷适于容纳导线锚60的一部分或全部。这些凹陷使得远侧部50在导线锚60上保持不突出的形态,并且提供更稳固的安装。
远侧部50还包括一个或多个电极56。电极56的结构可为业界中公知的结构。名称为“经血管神经刺激的电极结构”的、共同转让的第11/668,957号美国共同未决专利申请揭露了这种类型电极的例子,通过引用将其合并在此。本发明的多种实施例中,电极56可为环形电极或部分环形电极,并且可包括靠近电极56的药物洗脱环58。至少一个电极56适于将电脉冲经血管地传递至待刺激的神经或肌肉。根据本发明的一实施例,远侧部50包括多个沿远侧部50互相等距地设置的电极56。电极56可具有相同或不同的极性。此外,可通过导线体42将电极56连接至多个单独的传导件以使所述电极可单独编址。单独编址的电极使得可灵活选择电极,以对刺激的电流场和方向进行更佳的控制并且容许刺激和感测可有多种选择。根据本发明的一实施例,导线锚60可由超弹性材料制成。超弹性材料的例子包括镍钛诺、MP35N和本领域其它公知的材料。根据本发明的一实施例,使用本领域中公知的技术从激光切割镍钛诺管形成导线锚60。用激光来切割镍钛诺管以去除材料,从而留下至少一个直径与原始管径相同的套环、和一个或多个一体形成的可膨胀柱杆。可连接柱杆以形成一或多个网格。此外,柱杆可为编织或非编织结构。根据本发明的代替实施例,导线锚60可由一或多个超弹性线形成。与一体形成的柱杆类似,可连接这些线以形成一或多个网格。随着网格数量的增加,该锚的外观可类似于笼状或篮状。此外,这些线可为麻花状或非麻花状结构。此外,可使这些线为螺旋形、倾斜、弧形,并且这些线可为适于使得这些线上的张力为最小的多种结构。
根据本发明的一实施例,导线锚60包括至少一个固定在导线6的远侧部的一端的套环76。如图3A~3D所示,导线锚60包括固定至导线6的远侧部50的第一端68的近侧套环76和固定至第二端72的远侧套环80。至少一个可膨胀柱杆84从近侧套环76延伸至远侧套环80。可膨胀柱杆84这样形成,即其适于抵靠着远侧部50展开其中的血管的血管壁偏压包括电极的远侧部。根据本发明的另一实施例,导线锚60包括多个从近侧套环76延伸至远侧套环80的可膨胀柱杆84。根据本发明的另一实施例,如图3A~3D所示,形成导线锚60的可膨胀柱杆84包括连接至近侧套环76的近侧锥形区88和连接至远侧套环80的远侧锥形区92。锥形区88和92有助于导线6的远侧部50的传递和回缩。
根据本发明的代替实施例,如图4A~4C所示,导线锚60包括附接至远侧部50的第一端68的单个近侧套环76。如图4A~4C所示,导线锚60包括多个从近侧套环76朝向远侧部50的远侧端72延伸的可膨胀柱杆84。可膨胀柱杆84包括在一端连接至套环76的锥形近侧区域88。导线锚60的远侧端95不包括套环,锚60的远侧端95由此保持在末端开口。
根据本发明的另一实施例,导线锚60包括生物相容性涂覆物。根据多种实施例,该涂层包括聚氨酯、硅胶、EFTE、PTFE或者其它本领域公知的生物相容性材料。根据本发明的另一实施例,可使用生物相容性涂覆物单独地对多个柱杆84进行涂布。根据本发明的再一实施例,也可采用覆盖支架状的锚60的聚合物套(polymer sleeve)。
根据本发明的另一实施例,如图3A~4C所示,导线锚60适于从收缩形态膨胀至膨胀形态。该膨胀形态中,导线锚60将导线6的远侧部及其电极56向上按压抵靠着远侧部50展开在其中的血管100的血管壁。导线锚60以足够的径向力而膨胀,以有效地使得包括其电极56在内的远侧部50旋转及偏移离开目标刺激位置的程度为最小,由此固定及稳定血管100中的导线6的远侧部50。力沿着锚60膨胀后的长度分布,从而提供了更有效且更稳定的锚定机构。根据本发明的一个实施例,导线锚60将足够的径向膨胀力施加在该血管壁上,以使远侧部50偏出血管壁96的原始边界并且移向待刺激神经34,但不对血管壁96造成损害。从而,任何远侧部50上的电极56更靠近神经34。根据本发明的一实施例,电极56与待刺激神经34之间的距离约小于2mm。
远侧部50偏出血管壁96的原始边界不会造成血管壁96的损坏,也不会使得螺旋蚀穿血管壁96。经过一段较长时间后,远侧部50上形成组织鞘,这样其变得被封在血管壁96之内。血管100的外几何形状改变,使得位于血管100内部的导线6的远侧部50的外轮廓可见。
当膨胀时,导线锚60的长度范围为约6mm~约120mm。此外,根据本发明的一实施例,膨胀后的导线锚60的有效外径的范围为约3mm~约40mm。根据本发明的另一实施例,膨胀后的导线锚60的有效外径的范围为约10mm~约25mm。导线锚60的外径选择为,当处于膨胀形态时,导线锚60的外径稍大于其展开在其中的血管100的内径。根据一实施例,导线锚60的外径范围为大于远侧部50展开在其中的血管100的内径约5%~40%。根据另一实施例,导线锚60的尺寸为,其可与适于传递至左侧心脏以及患者脉管系统中其它位置的导线一起使用。
图5A~5C示出了在血管100内传递及展开过程中的导线6的远侧部50。收缩形态中,如图5A所示,远侧部50的有效长度与导线锚60的有效长度基本相等。根据本发明的一实施例,包括安装至其上的远侧部50的收缩导线锚60的外径范围为约1mm~约4mm。根据本发明的一实施例,收缩的导线锚60的总长度的范围为约6mm~约200mm。根据本发明的另一实施例,该收缩的导线锚的总长度的范围为约10mm~约80mm。
根据本发明的一实施例,如图5A~5C所示,导线锚60适于容纳在导管110或者其它能够容纳处于收缩形态、用于插入及在患者脉管系统(包括邻近待刺激神经的任何合适血管)中传递的导线锚60的合适部件中。根据本发明的另一实施例,导线体42包括内腔,所述内腔适于容纳通管丝或导丝之类有助于将包括导线锚60的远侧部50传递至血管内的刺激位置的导向件。根据这些实施例,使用单独或者互相组合的通管丝、导丝或导管110将包括导线锚60的远侧部50从膨胀形态收缩(完全地或部分地)至收缩形态(完全的或部分的),并且将导线6的远侧部50导向通过患者的脉管系统直至位于血管100内的刺激位置。处于收缩形态时,如图5A所示,包括安装至其上的远侧部50的导线锚60可插入患者的脉管系统并且被导向至血管100内的刺激位置。
根据本发明的另一实施例,如图5A~5C所示,导管110用于将包括安装至其上的远侧部50的导线锚60传递至血管内的刺激位置。一旦位于目标血管内部,如图5B所示,包括远侧部50的导线锚60从导管110部分展开并且旋转,或者进行其它操控。位于远侧部50的电极56可用于短暂刺激,并且由此测试可能的刺激位置。一旦使用由短暂刺激获得的信息而选定刺激位置,导管110可以回缩并且导线锚60完全展开,如图5C所示,以将导线6的远侧部50固定及稳定在该血管内的刺激位置,这样可在该目标刺激位置对相邻神经或肌肉产生经血管刺激。
根据本发明的再一实施例,导线锚60为可变地膨胀。即导线锚60适于在与管壁96卡合并保持摩擦力的同时根据血管100的尺寸和直径的自然变化而膨胀。例如,当位于颈内静脉18和22中,颈内静脉18和22的内部几何形状(直径和内部形状)可随着血流和血压变化。类似地,当患者处于直立位置时,血管100的直径会小于患者处于仰卧或俯卧位置时的直径。导线锚60通过膨胀解决管径不同的问题,以保持管壁96上的摩擦力,从而将远侧部50保持和稳定在血管中。
可使用常规技术将根据本发明多种实施例的导线6的远侧部50传送至靠近待刺激神经、肌肉或组织的血管内的刺激位置。根据本发明的一实施例,导线6可通过直接进入患者颈内静脉的经皮棒插入患者的脉管系统,以对迷走神经进行治疗。根据本发明的另一实施例,其上安装有远侧部50的导线锚60转换至收缩形态且前进通过患者的脉管系统,并且利用导管之类的导向件转递至刺激位置。一旦到达刺激位置并且该导管回缩,允许导线锚60从其收缩形态转换至与导线锚在其中展开的血管的管壁接触并摩擦卡合的膨胀形态。类似地,可将通管丝或一或多个导丝插入导线体42的内腔以将导线锚60从其预定的膨胀形状转换至收缩形态。然后将远侧部50通过脉管系统导向至血管内的刺激位置。一旦到达刺激位置,取出导丝或通管丝以使得导线锚60回复至其预定形状。亦可使用牵拉丝来进一步膨胀血管内的导线锚60,以使形成锚60的可膨胀柱杆84在管壁上施加附加的径向力,从而固定及稳定血管内的导线6。
无论使用何种传递方法,一旦包括安装至其上的远侧部50的导线锚60到达邻近待刺激神经34的血管100中的刺激位置时,导线锚60膨胀,从而推动安装至导线锚60外部的远侧部50与包括安装至其上的远侧部50的导线锚60在其中展开之血管100的血管壁96接触且摩擦卡合。导线体42并且导线锚60由此可在血管100内旋转以使得电极56朝向刺激目标定向。此外,可进一步旋转导线体42或对其定位直至通过管壁96到邻近待刺激神经或肌肉的、由电极56进行的电刺激阈值达到最大或最优。然后可对经电极56传递的刺激脉冲进行测量以判定是否已达到最优刺激阈值。
可通过在血管内旋转导线体42或者将导管110或导丝之类的导向部件重新导入以使导线锚60收缩(部分或完全),来重新定位远侧部50。然后,可重新定位以及/或者从血管100中取出安装到导线锚60外部的远侧部50。根据本发明的另一实施例,远侧部50可从导管110部分地展并以对神经进行短暂刺激。一旦使用短暂刺激辨识了合适的刺激位置,导管110可退回并且包括安装至其上的远侧部50的导线锚60在该刺激位置处可在该血管内完全展开。
可对所描述的示范实施例作出多种修改和附加而不脱离本发明的范围。例如,尽管上述实施例提及具体的特征,然而本发明的范围还包括具有不同特征组合的实施例和不包括所述特征的实施例。因此,本发明的范围意欲涵盖所有落入权利要求及其等价物范围之内的这种代替、修改及变化。
Claims (26)
1、一种用于刺激神经的医用电导线,其中所述导线适于传递至靠近待刺激神经的血管中的刺激位置,所述导线包括:
导电的导线体,其具有适于连接至脉冲生成器的近侧端;
包括至少一个电极的远侧部,所述电极适于穿过血管壁传递电脉冲;及
适于从收缩形态膨胀至预形成的膨胀形态的导线锚,其中,在所述收缩形态中,所述远侧部的有效长度基本等于收缩的所述导线锚的有效长度,并且其中所述远侧部这样连接至所述导线锚的外部,即在所述膨胀形态中所述导线锚将所述导线的所述远侧部按压抵靠在所述导线在其中展开的血管的至少一个管壁,从而固定及稳定所述血管内的所述导线的远侧部。
2、如权利要求1所述的医用电导线,其中所述血管选自颈内静脉、上腔静脉和头臂静脉,并且所述神经为迷走神经。
3、如权利要求1所述的医用电导线,其中所述导线锚包括超弹性材料。
4、如权利要求1所述的医用电导线,其中所述导线锚包括至少一个固定至所述导线的所述远侧部的套环。
5、如权利要求1所述的医用电导线,其中所述导线锚由超弹性材料的激光切割管形成,并且至少包括固定至所述导线体的第一端以及多个从所述第一端延伸至第二端的一体形成的柱杆。
6、如权利要求5所述的医用电导线,其中所述柱杆包括第一锥形区和第二锥形区,所述第一锥形区向下逐渐变细并且与固定至所述导线体的所述锚的第一端连接,所述第二锥形区向下逐渐变细并且与固定至所述导线体的所述锚的第二端连接。
7、如权利要求5所述的医用电导线,其中所述柱杆包括至少一个向下减小且与固定至所述导线体的一端连接的锥形区。
8、如权利要求1所述的医用电导线,其中所述导线锚包括与第二端径向偏离的第一端。
9、如权利要求1所述的医用电导线,其中所述导线锚包括与第二端径向对齐的第一端。
10、如权利要求1所述的医用电导线,其中所述导线锚包括生物相容性涂层。
11、如权利要求1所述的医用电导线,其中所述导线锚包括聚合物套。
12、如权利要求1所述的医用电导线,其中在所述膨胀形态中,所述导线锚的有效外径的范围为约3mm~约40mm。
13、如权利要求1所述的医用电导线,其中在所述膨胀形态中,所述导线锚的有效外径大于所述导线的远侧部在其中展开的所述血管的内径约5%~40%。
14、一种从相邻血管内部刺激神经的医用电导线,所述导线包括:
适于连接至脉冲生成器的近侧端;
包括至少一个电极的远侧部,所述电极适于穿过血管壁传递电脉冲;及
适于从收缩形态膨胀至预形成的膨胀形态的导线锚,其中所述远侧部连接至所述导线锚的外部。
15、如权利要求15所述的医用电导线,其中当所述导线锚处于所述收缩形态时,所述远侧部的有效长度基本等于所述导线锚的有效长度。
16、如权利要求15所述的医用电导线,其中所述导线锚包括超弹性材料。
17、如权利要求15所述的医用电导线,其中所述导线锚包括一个或多个柱杆,所述柱杆包括第一锥形区和第二锥形区,所述第一锥形区向下逐渐变细并且与固定至所述导线体的所述锚的第一端连接,所述第二锥形区向下逐渐变细并且与固定至所述导线体的所述锚的第二端连接。
18、如权利要求15所述的医用电导线,其中所述导线锚包括一个或多个柱杆,所述柱杆包括向下变细且与固定至所述导线体的所述锚的一端连接的第一锥形区。
19、如权利要求15所述的医用电导线,其中所述导线锚包括与第二端径向偏离的第一端。
20、如权利要求15所述的医用电导线,其中所述导线锚包括与第二端径向对齐的第一端。
21、如权利要求15所述的医用电导线,其中所述导线锚包括生物相容性涂层。
22、如权利要求15所述的医用电导线,其中所述导线锚包括聚合物套。
23、如权利要求15所述的医用电导线,其中在所述膨胀形态中,所述导线锚的有效外径的范围为约3mm~约40mm。
24、如权利要求15所述的医用电导线,其中在所述膨胀形态中,所述导线锚的有效外径大于所述导线的远侧部在其中展开的所述血管的内径约5%~40%。
25、如权利要求15所述的医用电导线,其中所述血管包括选自颈内静脉、上腔静脉和头臂静脉,并且所述神经为迷走神经。
26、一种用于固定及稳定血管内导线的导线锚组件,所述导线锚组件包括导线锚,所述导线锚至少包括连接至导线体的远侧部的第一端以及从所述第一端延伸至第二端的一体形成的多个柱杆,其中所述远侧部连接至所述导线锚的外部。
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103796713A (zh) * | 2011-06-27 | 2014-05-14 | 电子运动医疗有限公司 | 食管刺激装置及方法 |
CN106455985A (zh) * | 2014-05-16 | 2017-02-22 | 阿莱瓦神经治疗股份有限公司 | 与神经组织相互作用的装置及其制造和使用方法 |
US10695556B2 (en) | 2010-04-01 | 2020-06-30 | Ecole Polytechnique Federale De Lausanne | Device for interacting with neurological tissue and methods of making and using the same |
US10702692B2 (en) | 2018-03-02 | 2020-07-07 | Aleva Neurotherapeutics | Neurostimulation device |
US10952627B2 (en) | 2008-07-30 | 2021-03-23 | Ecole Polytechnique Federale De Lausanne | Apparatus and method for optimized stimulation of a neurological target |
US11123548B2 (en) | 2008-11-12 | 2021-09-21 | Ecole Polytechnique Federale De Lausanne | Microfabricated neurostimulation device |
US11167126B2 (en) | 2014-08-27 | 2021-11-09 | Aleva Neurotherapeutics | Deep brain stimulation lead |
US11311718B2 (en) | 2014-05-16 | 2022-04-26 | Aleva Neurotherapeutics Sa | Device for interacting with neurological tissue and methods of making and using the same |
Families Citing this family (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2676119C (en) * | 2007-01-29 | 2021-01-19 | Simon Fraser University | Transvascular nerve stimulation apparatus and methods |
US20080183255A1 (en) * | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Side port lead delivery system |
US7917230B2 (en) | 2007-01-30 | 2011-03-29 | Cardiac Pacemakers, Inc. | Neurostimulating lead having a stent-like anchor |
US20080183264A1 (en) * | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Electrode configurations for transvascular nerve stimulation |
US20080183187A1 (en) * | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Direct delivery system for transvascular lead |
US8244378B2 (en) | 2007-01-30 | 2012-08-14 | Cardiac Pacemakers, Inc. | Spiral configurations for intravascular lead stability |
US7949409B2 (en) | 2007-01-30 | 2011-05-24 | Cardiac Pacemakers, Inc. | Dual spiral lead configurations |
US20080183265A1 (en) * | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Transvascular lead with proximal force relief |
US11679262B2 (en) | 2007-03-09 | 2023-06-20 | Mainstay Medical Limited | Systems and methods for restoring muscle function to the lumbar spine |
US9072897B2 (en) | 2007-03-09 | 2015-07-07 | Mainstay Medical Limited | Systems and methods for restoring muscle function to the lumbar spine |
US11679261B2 (en) | 2007-03-09 | 2023-06-20 | Mainstay Medical Limited | Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention |
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US11331488B2 (en) | 2007-03-09 | 2022-05-17 | Mainstay Medical Limited | Systems and methods for enhancing function of spine stabilization muscles associated with a spine surgery intervention |
US10925637B2 (en) * | 2010-03-11 | 2021-02-23 | Mainstay Medical Limited | Methods of implanting electrode leads for use with implantable neuromuscular electrical stimulator |
US7925352B2 (en) * | 2008-03-27 | 2011-04-12 | Synecor Llc | System and method for transvascularly stimulating contents of the carotid sheath |
US8019443B2 (en) | 2008-04-01 | 2011-09-13 | Boston Scientific Neuromodulation Corporation | Anchoring units for leads of implantable electric stimulation systems and methods of making and using |
US9320891B2 (en) * | 2008-04-02 | 2016-04-26 | Boston Scientific Neuromodulation Corporation | Lead anchor for implantable devices and methods of manufacture and use |
US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
WO2010027630A1 (en) | 2008-09-05 | 2010-03-11 | Cardiac Pacemakers, Inc. | Conformal electrodes for shaped medical device lead body segments |
AU2009298554B2 (en) | 2008-10-01 | 2016-03-31 | Sherwin Hua | System and method for wire-guided pedicle screw stabilization of spinal vertebrae |
EP3714771A1 (en) | 2008-10-01 | 2020-09-30 | Inspire Medical Systems, Inc. | System for treating sleep apnea transvenously |
US8359107B2 (en) | 2008-10-09 | 2013-01-22 | Boston Scientific Neuromodulation Corporation | Electrode design for leads of implantable electric stimulation systems and methods of making and using |
JP5575789B2 (ja) | 2008-11-19 | 2014-08-20 | インスパイア・メディカル・システムズ・インコーポレイテッド | 睡眠呼吸障害の治療方法 |
US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
US20100185249A1 (en) * | 2009-01-22 | 2010-07-22 | Wingeier Brett M | Method and Devices for Adrenal Stimulation |
JP2012521864A (ja) | 2009-03-31 | 2012-09-20 | インスパイア・メディカル・システムズ・インコーポレイテッド | 睡眠に関連する異常呼吸を処置するシステムにおける経皮的アクセス方法 |
US20100256696A1 (en) * | 2009-04-07 | 2010-10-07 | Boston Scientific Neuromodulation Corporation | Anchoring Units For Implantable Electrical Stimulation Systems And Methods Of Making And Using |
US9887470B2 (en) | 2009-04-27 | 2018-02-06 | Boston Scienific Neuromodulation Corporation | Torque lock anchor and methods and devices using the anchor |
US9352147B2 (en) | 2009-04-27 | 2016-05-31 | Boston Scientific Neuromodulation Corporation | Torque lock anchor and methods and devices using the anchor |
WO2010141481A1 (en) * | 2009-06-01 | 2010-12-09 | Autonomic Technologies, Inc. | Methods and devices for adrenal stimulation |
US8412349B2 (en) * | 2009-06-04 | 2013-04-02 | Boston Scientific Neuromodulation Corporation | Three-piece button anchor and methods and devices using the anchor |
US11786725B2 (en) | 2012-06-13 | 2023-10-17 | Mainstay Medical Limited | Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same |
US9999763B2 (en) | 2012-06-13 | 2018-06-19 | Mainstay Medical Limited | Apparatus and methods for anchoring electrode leads adjacent to nervous tissue |
WO2011112773A2 (en) | 2010-03-11 | 2011-09-15 | Mainstay Medical, Inc. | Modular stimulator for treatment of back pain, implantable rf ablation system and methods of use |
US11684774B2 (en) | 2010-03-11 | 2023-06-27 | Mainstay Medical Limited | Electrical stimulator for treatment of back pain and methods of use |
US9950159B2 (en) | 2013-10-23 | 2018-04-24 | Mainstay Medical Limited | Systems and methods for restoring muscle function to the lumbar spine and kits for implanting the same |
JP5537213B2 (ja) * | 2010-03-26 | 2014-07-02 | オリンパス株式会社 | 電気刺激電極組立体 |
JP2011194053A (ja) * | 2010-03-19 | 2011-10-06 | Olympus Corp | 生体植え込み電極 |
US9050453B2 (en) | 2010-03-19 | 2015-06-09 | National Cerebral And Cardiovascular Center | Electrostimulation system, and electrostimulation electrode assembly and biological implantable electrode therefore |
EP2563255B1 (en) * | 2010-04-26 | 2017-03-22 | Medtronic Ardian Luxembourg S.à.r.l. | Catheter apparatuses and systems for renal neuromodulation |
AU2011282294B9 (en) * | 2010-07-19 | 2014-09-25 | Cardiac Pacemakers, Inc. | Minimally invasive lead system for vagus nerve stimulation |
WO2012019034A1 (en) * | 2010-08-05 | 2012-02-09 | Cardiac Pacemakers, Inc. | System and method for securing a lead in a vessel |
WO2012025245A1 (de) | 2010-08-26 | 2012-03-01 | Acandis Gmbh & Co. Kg | Elektrode für medizinische anwendungen, system mit einer derartigen elektrode und verfahren zur herstellung einer derartigen elektrode |
US9220899B2 (en) | 2010-08-26 | 2015-12-29 | Acandis Gmbh & Co. Kg | Electrode for medical applications, system having an electrode, and method for producing an electrode |
DE102010035543A1 (de) | 2010-08-26 | 2012-03-01 | Acandis Gmbh & Co. Kg | Medizinische Vorrichtung und System mit einer derartigen Vorrichtung |
US8934956B2 (en) * | 2010-08-31 | 2015-01-13 | Interventional Autonomics Corporation | Intravascular electrodes and anchoring devices for transvascular stimulation |
DE102011009020B4 (de) | 2011-01-20 | 2022-03-17 | Acandis Gmbh | Hörprothese und Verfahren zur Herstellung einer derartigen Hörprothese |
EP2701795B1 (en) | 2011-04-28 | 2020-12-09 | Interventional Autonomics Corporation | Neuromodulation systems for treating acute heart failure syndromes |
US9446240B2 (en) | 2011-07-11 | 2016-09-20 | Interventional Autonomics Corporation | System and method for neuromodulation |
US20130072995A1 (en) | 2011-07-11 | 2013-03-21 | Terrance Ransbury | Catheter system for acute neuromodulation |
AU2012299373A1 (en) | 2011-07-11 | 2014-02-27 | Interventional Autonomics Corporation | System and method for neuromodulation |
AU2012290152B2 (en) | 2011-08-02 | 2016-08-11 | Mainstay Medical Limited | Apparatus for anchoring electrode leads for use with implantable neuromuscular electrical stimulator |
JP2013034535A (ja) * | 2011-08-04 | 2013-02-21 | Olympus Corp | 電気刺激電極組立体 |
WO2013023218A1 (en) | 2011-08-11 | 2013-02-14 | Inspire Medical Systems, Inc. | System for selecting a stimulation protocol based on sensed respiratory effort |
US20140288667A1 (en) | 2011-10-04 | 2014-09-25 | Thomas James Oxley | Sensing or Stimulating Activity of Tissue |
SG11201402610QA (en) | 2011-12-09 | 2014-10-30 | Metavention Inc | Therapeutic neuromodulation of the hepatic system |
CN107126622A (zh) | 2012-03-05 | 2017-09-05 | 西蒙·弗雷瑟大学 | 神经刺激系统 |
US9186501B2 (en) | 2012-06-13 | 2015-11-17 | Mainstay Medical Limited | Systems and methods for implanting electrode leads for use with implantable neuromuscular electrical stimulator |
US10195419B2 (en) | 2012-06-13 | 2019-02-05 | Mainstay Medical Limited | Electrode leads for use with implantable neuromuscular electrical stimulator |
BR112014032002A2 (pt) | 2012-06-21 | 2017-06-27 | Univ Fraser Simon | sistemas de estimulação de diafragma transvascular e métodos de utilização |
US20140067000A1 (en) * | 2012-09-06 | 2014-03-06 | Ticona Llc | Implantable Medical Device Containing Fibers Formed from a Liquid Crystalline Polymer |
WO2014043235A1 (en) | 2012-09-12 | 2014-03-20 | Boston Scientific Scimed, Inc. | Sensing cardiac conduction system during valve deployment |
US10265122B2 (en) | 2013-03-15 | 2019-04-23 | Boston Scientific Scimed, Inc. | Nerve ablation devices and related methods of use |
EP2789364A1 (en) * | 2013-04-08 | 2014-10-15 | Sapiens Steering Brain Stimulation B.V. | A lead, especially a lead for neural applications |
US9919146B2 (en) | 2013-05-01 | 2018-03-20 | Sherwin Hua | Methods and systems for intraventricular brain stimulation |
US10406353B2 (en) | 2013-05-14 | 2019-09-10 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads with anchoring unit and electrode arrangement and methods of making and using |
US9839777B2 (en) | 2013-08-14 | 2017-12-12 | Syntilla Medical LLC | Implantable neurostimulation lead for head pain |
US9042991B2 (en) | 2013-08-14 | 2015-05-26 | Syntilla Medical LLC | Implantable head mounted neurostimulation system for head pain |
US9427566B2 (en) | 2013-08-14 | 2016-08-30 | Syntilla Medical LLC | Implantable neurostimulation lead for head pain |
US9517334B2 (en) | 2013-08-19 | 2016-12-13 | Boston Scientific Neuromodulation Corporation | Lead anchors and systems and methods employing the lead anchors |
US9216563B2 (en) | 2013-08-19 | 2015-12-22 | Boston Scientific Neuromodulation Corporation | Lead anchor with adhesive and systems and methods using the lead anchor |
US9498635B2 (en) | 2013-10-16 | 2016-11-22 | Syntilla Medical LLC | Implantable head located radiofrequency coupled neurostimulation system for head pain |
US10960215B2 (en) | 2013-10-23 | 2021-03-30 | Nuxcel, Inc. | Low profile head-located neurostimulator and method of fabrication |
US10258805B2 (en) | 2013-10-23 | 2019-04-16 | Syntilla Medical, Llc | Surgical method for implantable head mounted neurostimulation system for head pain |
AU2014351473B2 (en) | 2013-11-22 | 2019-11-07 | Lungpacer Medical Inc. | Apparatus and methods for assisted breathing by transvascular nerve stimulation |
EP3824949B1 (en) | 2014-01-21 | 2023-12-20 | Lungpacer Medical Inc. | Systems for optimization of multi-electrode nerve pacing |
US9415212B2 (en) | 2014-02-28 | 2016-08-16 | Boston Scientific Neuromodulation Corporation | Side loading lead anchor and methods of making and using thereof |
US9364658B2 (en) | 2014-03-03 | 2016-06-14 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads with multiple anchoring units and methods of making and using |
US9669210B2 (en) | 2014-04-22 | 2017-06-06 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with folding anchoring units and methods of making and using |
US9987482B2 (en) | 2014-05-27 | 2018-06-05 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using reversible mechanical lead anchors for electrical stimulation systems |
JP6335025B2 (ja) * | 2014-05-28 | 2018-05-30 | オリンパス株式会社 | 医療用電気刺激電極 |
JP6274972B2 (ja) * | 2014-05-29 | 2018-02-07 | オリンパス株式会社 | 医療用電気刺激電極及び医療用電気刺激装置 |
US9649489B2 (en) * | 2014-06-02 | 2017-05-16 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with anchoring units having struts and methods of making and using |
US10130809B2 (en) | 2014-06-13 | 2018-11-20 | Nervana, LLC | Transcutaneous electrostimulator and methods for electric stimulation |
US9782584B2 (en) | 2014-06-13 | 2017-10-10 | Nervana, LLC | Transcutaneous electrostimulator and methods for electric stimulation |
US9533141B2 (en) | 2014-07-07 | 2017-01-03 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with elongate anchoring elements |
WO2016020846A1 (en) | 2014-08-06 | 2016-02-11 | Mainstay Medical Limited | Electrode leads for use with implantable neuromuscular electrical stimulator |
US10471268B2 (en) | 2014-10-16 | 2019-11-12 | Mainstay Medical Limited | Systems and methods for monitoring muscle rehabilitation |
JP2016077801A (ja) * | 2014-10-22 | 2016-05-16 | オリンパス株式会社 | 電極ユニットおよび神経刺激システム |
EP3242709A4 (en) * | 2015-01-08 | 2018-10-17 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | Cardiac stimulation of atrial-ventricle pathways and/or associated tissue |
JP6576367B2 (ja) * | 2015-01-13 | 2019-09-18 | アドリアカイム株式会社 | 神経刺激電極 |
WO2016125250A1 (ja) * | 2015-02-03 | 2016-08-11 | オリンパス株式会社 | 医療用電気刺激電極 |
CN107864617B (zh) | 2015-03-19 | 2021-08-20 | 启迪医疗仪器公司 | 用于治疗睡眠障碍性呼吸的刺激 |
JP6491939B2 (ja) * | 2015-04-22 | 2019-03-27 | オリンパス株式会社 | 神経刺激システム |
US9636498B2 (en) | 2015-08-03 | 2017-05-02 | Boston Scientific Neuromodulation Corporation | Lead anchor with a wedge and systems using the lead anchor |
WO2017070252A1 (en) | 2015-10-20 | 2017-04-27 | The University Of Melbourne | Medical device for sensing and or stimulating tissue |
US9717917B2 (en) | 2016-01-06 | 2017-08-01 | Syntilla Medical LLC | Charging system incorporating independent charging and communication with multiple implanted devices |
US10071242B2 (en) | 2016-02-29 | 2018-09-11 | Boston Scientific Neuromodulation Corporation | Lead anchor for an electrical stimulation system |
EP3436140B1 (en) | 2016-04-01 | 2021-01-06 | Cyberonics, Inc. | Vagus nerve stimulation patient selection |
WO2017201058A1 (en) | 2016-05-17 | 2017-11-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for anchoring a lead for neurostimulation of a target anatomy |
US10524859B2 (en) | 2016-06-07 | 2020-01-07 | Metavention, Inc. | Therapeutic tissue modulation devices and methods |
US10327810B2 (en) | 2016-07-05 | 2019-06-25 | Mainstay Medical Limited | Systems and methods for enhanced implantation of electrode leads between tissue layers |
US10987514B2 (en) | 2016-07-15 | 2021-04-27 | Kenneth M. Peters | System and method for minimally invasive lead implantation for cavernosal nerve stimulation controlled and powered wirelessly from an external source |
US10709886B2 (en) | 2017-02-28 | 2020-07-14 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with elongate anchoring elements and methods of making and using |
US10835739B2 (en) | 2017-03-24 | 2020-11-17 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with elongate anchoring elements and methods of making and using |
WO2018195083A1 (en) | 2017-04-18 | 2018-10-25 | The University Of Melbourne | Endovascular device for sensing and or stimulating tissue |
US10857351B2 (en) | 2017-04-28 | 2020-12-08 | Boston Scientific Neuromodulation Corporation | Lead anchors for electrical stimulation leads and systems and methods of making and using |
US10293164B2 (en) | 2017-05-26 | 2019-05-21 | Lungpacer Medical Inc. | Apparatus and methods for assisted breathing by transvascular nerve stimulation |
CN111163834A (zh) | 2017-06-30 | 2020-05-15 | 隆佩瑟尔医疗公司 | 用于预防、减轻和/或治疗认知损伤的装置 |
US10195429B1 (en) | 2017-08-02 | 2019-02-05 | Lungpacer Medical Inc. | Systems and methods for intravascular catheter positioning and/or nerve stimulation |
US10940308B2 (en) | 2017-08-04 | 2021-03-09 | Lungpacer Medical Inc. | Systems and methods for trans-esophageal sympathetic ganglion recruitment |
AU2018354250A1 (en) | 2017-10-25 | 2020-06-11 | Epineuron Technologies Inc. | Systems and methods for delivering neuroregenerative therapy |
US10589089B2 (en) | 2017-10-25 | 2020-03-17 | Epineuron Technologies Inc. | Systems and methods for delivering neuroregenerative therapy |
WO2020097331A1 (en) | 2018-11-08 | 2020-05-14 | Lungpacer Medical Inc. | Stimulation systems and related user interfaces |
EP3968932A4 (en) | 2019-05-16 | 2023-01-18 | Lungpacer Medical Inc. | SYSTEMS AND METHODS FOR DETECTION AND STIMULATION |
US11771900B2 (en) | 2019-06-12 | 2023-10-03 | Lungpacer Medical Inc. | Circuitry for medical stimulation systems |
US11247043B2 (en) * | 2019-10-01 | 2022-02-15 | Epineuron Technologies Inc. | Electrode interface devices for delivery of neuroregenerative therapy |
PL4056135T3 (pl) | 2021-03-09 | 2023-10-02 | Circle Safe | Stymulacja nerwu przeponowego |
WO2023014725A1 (en) * | 2021-08-03 | 2023-02-09 | Texas Medical Center | Phrenic nerve pacing device |
Family Cites Families (139)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US38654A (en) * | 1863-05-26 | Improvement in lifting-jacks | ||
US38705A (en) * | 1863-05-26 | Improvement in sewing-machine guides | ||
US656690A (en) * | 1900-03-20 | 1900-08-28 | Henry Brackebush | Harvesting-machine. |
US4365634A (en) * | 1979-12-06 | 1982-12-28 | C. R. Bard, Inc. | Medical electrode construction |
US4414986A (en) | 1982-01-29 | 1983-11-15 | Medtronic, Inc. | Biomedical stimulation lead |
EP0108752A1 (en) | 1982-05-24 | 1984-05-23 | McCORKLE, Charles E. Jr. | Intravenous channel cardiac electrode and lead assembly and method |
US4774949A (en) * | 1983-06-14 | 1988-10-04 | Fogarty Thomas J | Deflector guiding catheter |
DE8717643U1 (zh) | 1987-05-12 | 1989-09-21 | Foerster, Ernst, Dr.Med. Dr.Rer.Nat. | |
US4944088A (en) * | 1988-05-25 | 1990-07-31 | Medtronic, Inc. | Ring electrode for multiconductor pacing leads |
US4920979A (en) * | 1988-10-12 | 1990-05-01 | Huntington Medical Research Institute | Bidirectional helical electrode for nerve stimulation |
US5074313A (en) | 1989-03-20 | 1991-12-24 | Cardiac Pacemakers, Inc. | Porous electrode with enhanced reactive surface |
US5016808A (en) * | 1989-09-14 | 1991-05-21 | Cardiac Pacemakers, Inc. | Implantable tapered spiral endocardial lead for use in internal defibrillation |
US5117828A (en) * | 1989-09-25 | 1992-06-02 | Arzco Medical Electronics, Inc. | Expandable esophageal catheter |
US5265608A (en) * | 1990-02-22 | 1993-11-30 | Medtronic, Inc. | Steroid eluting electrode for peripheral nerve stimulation |
US5221261A (en) * | 1990-04-12 | 1993-06-22 | Schneider (Usa) Inc. | Radially expandable fixation member |
US5170802A (en) | 1991-01-07 | 1992-12-15 | Medtronic, Inc. | Implantable electrode for location within a blood vessel |
US5251634A (en) | 1991-05-03 | 1993-10-12 | Cyberonics, Inc. | Helical nerve electrode |
JPH066170B2 (ja) | 1991-08-28 | 1994-01-26 | 中島 博 | ペースメーカのペーシング・リード |
US5330515A (en) * | 1992-06-17 | 1994-07-19 | Cyberonics, Inc. | Treatment of pain by vagal afferent stimulation |
DE69315704T3 (de) * | 1992-10-01 | 2002-08-01 | Cardiac Pacemakers Inc | Stentartige struktur für entflimmerungselektroden |
SE9203732D0 (sv) * | 1992-12-11 | 1992-12-11 | Siemens Elema Ab | Elektrodsystem foer defibrillator |
SE9203733D0 (sv) * | 1992-12-11 | 1992-12-11 | Siemens Elema Ab | Defibrilleringselektrod |
US5387233A (en) * | 1993-01-11 | 1995-02-07 | Incontrol, Inc. | Intravenous cardiac lead with improved fixation and method |
US5792187A (en) * | 1993-02-22 | 1998-08-11 | Angeion Corporation | Neuro-stimulation to control pain during cardioversion defibrillation |
US5383922A (en) * | 1993-03-15 | 1995-01-24 | Medtronic, Inc. | RF lead fixation and implantable lead |
US5354318A (en) | 1993-04-30 | 1994-10-11 | Medtronic, Inc. | Method and apparatus for monitoring brain hemodynamics |
US6277107B1 (en) * | 1993-08-13 | 2001-08-21 | Daig Corporation | Guiding introducer for introducing medical devices into the coronary sinus and process for using same |
AU685161B2 (en) | 1993-09-17 | 1998-01-15 | Edwards Lifesciences Ag | Endovascular system for arresting the heart |
US5476498A (en) * | 1994-08-15 | 1995-12-19 | Incontrol, Inc. | Coronary sinus channel lead and method |
US5639276A (en) * | 1994-09-23 | 1997-06-17 | Rapid Development Systems, Inc. | Device for use in right ventricular placement and method for using same |
US5540730A (en) * | 1995-06-06 | 1996-07-30 | Cyberonics, Inc. | Treatment of motility disorders by nerve stimulation |
US5766203A (en) * | 1995-07-20 | 1998-06-16 | Intelliwire, Inc. | Sheath with expandable distal extremity and balloon catheters and stents for use therewith and method |
SE9504675D0 (sv) | 1995-12-28 | 1995-12-28 | Pacesetter Ab | Implanterbar elektrodkabelanordning med flera elektrodkontaktelement |
US5772693A (en) * | 1996-02-09 | 1998-06-30 | Cardiac Control Systems, Inc. | Single preformed catheter configuration for a dual-chamber pacemaker system |
US5776178A (en) | 1996-02-21 | 1998-07-07 | Medtronic, Inc. | Medical electrical lead with surface treatment for enhanced fixation |
US5755761A (en) * | 1996-04-26 | 1998-05-26 | Pharmatarget, Inc. | Atrial pacing catheter and method having multiple electrodes in the right atrium and coronary sinus |
US7225019B2 (en) * | 1996-04-30 | 2007-05-29 | Medtronic, Inc. | Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure |
US6006134A (en) * | 1998-04-30 | 1999-12-21 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers |
US6449507B1 (en) * | 1996-04-30 | 2002-09-10 | Medtronic, Inc. | Method and system for nerve stimulation prior to and during a medical procedure |
US7269457B2 (en) * | 1996-04-30 | 2007-09-11 | Medtronic, Inc. | Method and system for vagal nerve stimulation with multi-site cardiac pacing |
USRE38705E1 (en) * | 1996-04-30 | 2005-02-22 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers |
US5755714A (en) * | 1996-09-17 | 1998-05-26 | Eclipse Surgical Technologies, Inc. | Shaped catheter for transmyocardial revascularization |
EP0842640A1 (de) * | 1996-11-13 | 1998-05-20 | Sulzer Osypka GmbH | Herzkatheter mit Elektrode auf aufspannbarer Einrichtung |
US5803928A (en) * | 1997-01-24 | 1998-09-08 | Cardiac Pacemakers, Inc. | Side access "over the wire" pacing lead |
US5954761A (en) * | 1997-03-25 | 1999-09-21 | Intermedics Inc. | Implantable endocardial lead assembly having a stent |
US6479523B1 (en) * | 1997-08-26 | 2002-11-12 | Emory University | Pharmacologic drug combination in vagal-induced asystole |
US5922014A (en) * | 1997-09-02 | 1999-07-13 | Medtronic, Inc. | Single pass lead and method of use |
US5871531A (en) | 1997-09-25 | 1999-02-16 | Medtronic, Inc. | Medical electrical lead having tapered spiral fixation |
AU3672399A (en) | 1998-04-29 | 1999-11-16 | Emory University | Cardiac pacing lead and delivery system |
US6066165A (en) | 1998-04-30 | 2000-05-23 | Racz; Gabor B | Medical lead with sigma feature |
WO1999065561A1 (en) * | 1998-06-19 | 1999-12-23 | Cordis Webster, Inc. | Method and apparatus for transvascular treatment of tachycardia and fibrillation |
FR2784300B1 (fr) * | 1998-10-13 | 2000-12-08 | Ela Medical Sa | Sonde de stimulation du ventricule gauche implantable dans le reseau veineux coronarien pour dispositif medical implantable actif, notamment stimulateur de type "multisite" |
IT1305062B1 (it) * | 1998-12-23 | 2001-04-10 | Leonardo Cammilli | Catetere ad introduzione singola per la stimolazione multisite dellequattro camere cardiache per il trattamento di patologie quali la |
US6321123B1 (en) * | 1999-03-08 | 2001-11-20 | Medtronic Inc. | J-shaped coronary sinus lead |
US6325797B1 (en) * | 1999-04-05 | 2001-12-04 | Medtronic, Inc. | Ablation catheter and method for isolating a pulmonary vein |
US6055456A (en) * | 1999-04-29 | 2000-04-25 | Medtronic, Inc. | Single and multi-polar implantable lead for sacral nerve electrical stimulation |
US7840278B1 (en) * | 1999-06-25 | 2010-11-23 | Puskas John D | Devices and methods for vagus nerve stimulation |
US6263250B1 (en) * | 1999-07-13 | 2001-07-17 | Cardiac Pacemakers, Inc. | Ring electrode with porous member |
US6363288B1 (en) * | 1999-08-20 | 2002-03-26 | Pacesetter, Inc. | CS lead with single site sensing and dual site pacing |
US6363286B1 (en) * | 1999-09-24 | 2002-03-26 | Cardiac Pacemakers, Inc. | High impedance electrode assembly |
JP4558251B2 (ja) | 1999-11-22 | 2010-10-06 | ボストン サイエンティフィック リミテッド | 身体組織と接触させて診断要素および治療要素を支持するためのループ構造体 |
EP1106202A3 (de) * | 1999-11-30 | 2004-03-31 | BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin | Elektrode zu intravaskuläran Stimulation, Kardioversion und/oder Defibrillation |
US6442413B1 (en) * | 2000-05-15 | 2002-08-27 | James H. Silver | Implantable sensor |
US6584362B1 (en) * | 2000-08-30 | 2003-06-24 | Cardiac Pacemakers, Inc. | Leads for pacing and/or sensing the heart from within the coronary veins |
SE0003341D0 (sv) * | 2000-09-18 | 2000-09-18 | St Jude Medical | A coating method |
US6522926B1 (en) | 2000-09-27 | 2003-02-18 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
US7212867B2 (en) | 2000-12-07 | 2007-05-01 | Medtronic, Inc. | Directional brain stimulation and recording leads |
US6697676B2 (en) * | 2000-12-21 | 2004-02-24 | Medtronic, Inc. | Medical electrical lead having an expandable electrode assembly |
US6704604B2 (en) * | 2000-12-28 | 2004-03-09 | Medtronic, Inc. | System and method for promoting selective tissue in-growth for an implantable medical device |
US6934589B2 (en) * | 2000-12-29 | 2005-08-23 | Medtronic, Inc. | System and method for placing endocardial leads |
US6609025B2 (en) * | 2001-01-02 | 2003-08-19 | Cyberonics, Inc. | Treatment of obesity by bilateral sub-diaphragmatic nerve stimulation |
DE10103288A1 (de) | 2001-01-25 | 2002-08-01 | Patrick Schauerte | Gefäßschleuse zur intravaskulären Nervenstimulation und Flüssigkeitsinfusion |
US6564096B2 (en) * | 2001-02-28 | 2003-05-13 | Robert A. Mest | Method and system for treatment of tachycardia and fibrillation |
US6766203B2 (en) | 2001-04-05 | 2004-07-20 | Pacesetter, Inc. | Body implantable lead with improved tip electrode assembly |
EP1392391A4 (en) | 2001-05-07 | 2009-12-09 | Cochlear Ltd | PROCESS FOR PRODUCING ELECTROCONDUCTIVE COMPONENTS |
US6600956B2 (en) * | 2001-08-21 | 2003-07-29 | Cyberonics, Inc. | Circumneural electrode assembly |
US6760626B1 (en) * | 2001-08-29 | 2004-07-06 | Birinder R. Boveja | Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system |
US7778711B2 (en) * | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Reduction of heart rate variability by parasympathetic stimulation |
US6999819B2 (en) | 2001-08-31 | 2006-02-14 | Medtronic, Inc. | Implantable medical electrical stimulation lead fixation method and apparatus |
US6934583B2 (en) | 2001-10-22 | 2005-08-23 | Pacesetter, Inc. | Implantable lead and method for stimulating the vagus nerve |
US7052487B2 (en) * | 2001-10-26 | 2006-05-30 | Cohn William E | Method and apparatus for reducing mitral regurgitation |
US6671562B2 (en) * | 2001-11-09 | 2003-12-30 | Oscor Inc. | High impedance drug eluting cardiac lead |
US6961621B2 (en) * | 2001-12-04 | 2005-11-01 | Cardiac Pacemakers, Inc. | Apparatus and method for stabilizing an implantable lead |
US6741878B2 (en) * | 2001-12-14 | 2004-05-25 | Biosense Webster, Inc. | Basket catheter with improved expansion mechanism |
US20030199961A1 (en) * | 2002-04-03 | 2003-10-23 | Bjorklund Vicki L. | Method and apparatus for fixating a pacing lead of an implantable medical device |
US20050065553A1 (en) * | 2003-06-13 | 2005-03-24 | Omry Ben Ezra | Applications of vagal stimulation |
US20040015205A1 (en) * | 2002-06-20 | 2004-01-22 | Whitehurst Todd K. | Implantable microstimulators with programmable multielectrode configuration and uses thereof |
US7860570B2 (en) * | 2002-06-20 | 2010-12-28 | Boston Scientific Neuromodulation Corporation | Implantable microstimulators and methods for unidirectional propagation of action potentials |
US7115134B2 (en) * | 2002-07-22 | 2006-10-03 | Chambers Technology, Llc. | Catheter with flexible tip and shape retention |
US7993351B2 (en) | 2002-07-24 | 2011-08-09 | Pressure Products Medical Supplies, Inc. | Telescopic introducer with a compound curvature for inducing alignment and method of using the same |
US7058454B1 (en) * | 2002-08-30 | 2006-06-06 | Pacesetter, Inc. | Stimulation/sensing electrodes for use with implantable cardiac leads in coronary vein locations |
US7107105B2 (en) * | 2002-09-24 | 2006-09-12 | Medtronic, Inc. | Deployable medical lead fixation system and method |
US7282213B2 (en) * | 2002-09-30 | 2007-10-16 | Medtronic, Inc. | Method for applying a drug coating to a medical device |
US20030229380A1 (en) * | 2002-10-31 | 2003-12-11 | Adams John M. | Heart failure therapy device and method |
EP1421972A3 (de) * | 2002-11-20 | 2004-10-13 | W. C. Heraeus GmbH & Co. KG | Stimulationselektrode und deren Verwendung |
US7047084B2 (en) * | 2002-11-20 | 2006-05-16 | Advanced Neuromodulation Systems, Inc. | Apparatus for directionally stimulating nerve tissue |
US6882887B1 (en) | 2002-12-16 | 2005-04-19 | Pacesetter, Inc. | Implantable lead and electrode portion |
US20040260374A1 (en) * | 2002-12-19 | 2004-12-23 | Cardiac Pacemakers, Inc. | Implantable lead with fixation mechanism in the pulmonary artery |
US20040133240A1 (en) * | 2003-01-07 | 2004-07-08 | Cardiac Dimensions, Inc. | Electrotherapy system, device, and method for treatment of cardiac valve dysfunction |
US7158838B2 (en) | 2003-01-31 | 2007-01-02 | Medtronic, Inc. | Arrangement for implanting a miniaturized cardiac lead having a fixation helix |
US7167750B2 (en) * | 2003-02-03 | 2007-01-23 | Enteromedics, Inc. | Obesity treatment with electrically induced vagal down regulation |
US7343206B2 (en) * | 2003-04-25 | 2008-03-11 | Medtronic, Inc. | Implantable medical lead and system, and method of use thereof |
JP4430899B2 (ja) * | 2003-07-30 | 2010-03-10 | 株式会社リコー | 画像形成装置および反射濃度センサの検出特性検出方法 |
JP4387724B2 (ja) * | 2003-08-12 | 2009-12-24 | テルモ株式会社 | 生体植込み用電極リード |
US20050038489A1 (en) * | 2003-08-14 | 2005-02-17 | Grill Warren M. | Electrode array for use in medical stimulation and methods thereof |
US20050080472A1 (en) * | 2003-10-10 | 2005-04-14 | Atkinson Robert Emmett | Lead stabilization devices and methods |
EP1684842B1 (en) * | 2003-10-27 | 2013-03-06 | Petrus Antonius Besselink | Self-activating endoluminal device |
US20050131467A1 (en) * | 2003-11-02 | 2005-06-16 | Boveja Birinder R. | Method and apparatus for electrical stimulation therapy for at least one of atrial fibrillation, congestive heart failure, inappropriate sinus tachycardia, and refractory hypertension |
US8126560B2 (en) * | 2003-12-24 | 2012-02-28 | Cardiac Pacemakers, Inc. | Stimulation lead for stimulating the baroreceptors in the pulmonary artery |
DE602004022713D1 (de) | 2003-12-24 | 2009-10-01 | Cardiac Pacemakers Inc | Leitung zur stimulierung der barorezeptoren in der pulmonalarterie |
US8024050B2 (en) | 2003-12-24 | 2011-09-20 | Cardiac Pacemakers, Inc. | Lead for stimulating the baroreceptors in the pulmonary artery |
US7460906B2 (en) * | 2003-12-24 | 2008-12-02 | Cardiac Pacemakers, Inc. | Baroreflex stimulation to treat acute myocardial infarction |
US8412348B2 (en) * | 2004-05-06 | 2013-04-02 | Boston Scientific Neuromodulation Corporation | Intravascular self-anchoring integrated tubular electrode body |
US8128680B2 (en) * | 2005-01-10 | 2012-03-06 | Taheri Laduca Llc | Apparatus and method for deploying an implantable device within the body |
US7840266B2 (en) * | 2005-03-11 | 2010-11-23 | Cardiac Pacemakers, Inc. | Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy |
WO2006098996A1 (en) | 2005-03-11 | 2006-09-21 | Cardiac Pacemakers, Inc. | Combined neural stimulation and cardiac resynchronization therapy |
US7499748B2 (en) * | 2005-04-11 | 2009-03-03 | Cardiac Pacemakers, Inc. | Transvascular neural stimulation device |
US7477946B2 (en) * | 2005-04-26 | 2009-01-13 | Cardiac Pacemakers, Inc. | Fixation device for coronary venous lead |
US7676275B1 (en) * | 2005-05-02 | 2010-03-09 | Pacesetter, Inc. | Endovascular lead for chronic nerve stimulation |
US7765000B2 (en) | 2005-05-10 | 2010-07-27 | Cardiac Pacemakers, Inc. | Neural stimulation system with pulmonary artery lead |
US7617003B2 (en) * | 2005-05-16 | 2009-11-10 | Cardiac Pacemakers, Inc. | System for selective activation of a nerve trunk using a transvascular reshaping lead |
US8019438B2 (en) | 2005-06-28 | 2011-09-13 | Cardiac Pacemakers, Inc. | Anchor for electrode delivery system |
EP1993658B1 (en) * | 2006-03-02 | 2009-10-07 | St Jude Medical AB | A medical implantable lead and a method for manufacturing of the same |
US20080051861A1 (en) * | 2006-04-28 | 2008-02-28 | Cross Thomas E | Implantable medical assemblies with improved flexibility, extensibility and positionability with branched structures |
US8311633B2 (en) | 2006-12-04 | 2012-11-13 | Synecor Llc | Intravascular implantable device having superior anchoring arrangement |
US20080147168A1 (en) | 2006-12-04 | 2008-06-19 | Terrance Ransbury | Intravascular implantable device having detachable tether arrangement |
US20080208305A1 (en) | 2007-01-17 | 2008-08-28 | The Cleveland Clinic Foundation | Apparatus and methods for treating pulmonary conditions |
US8244378B2 (en) | 2007-01-30 | 2012-08-14 | Cardiac Pacemakers, Inc. | Spiral configurations for intravascular lead stability |
US7949409B2 (en) | 2007-01-30 | 2011-05-24 | Cardiac Pacemakers, Inc. | Dual spiral lead configurations |
US20080183255A1 (en) | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Side port lead delivery system |
US20080183265A1 (en) | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Transvascular lead with proximal force relief |
US20080183187A1 (en) | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Direct delivery system for transvascular lead |
US20080183264A1 (en) | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Electrode configurations for transvascular nerve stimulation |
US20080183186A1 (en) | 2007-01-30 | 2008-07-31 | Cardiac Pacemakers, Inc. | Method and apparatus for delivering a transvascular lead |
US7917230B2 (en) * | 2007-01-30 | 2011-03-29 | Cardiac Pacemakers, Inc. | Neurostimulating lead having a stent-like anchor |
US20100049289A1 (en) | 2007-07-10 | 2010-02-25 | Ams Research Corporation | Tissue anchor |
US7925352B2 (en) | 2008-03-27 | 2011-04-12 | Synecor Llc | System and method for transvascularly stimulating contents of the carotid sheath |
WO2009135082A1 (en) | 2008-04-30 | 2009-11-05 | Medtronic, Inc. | Techniques for placing medical leads for electrical stimulation of nerve tissue |
WO2012019034A1 (en) | 2010-08-05 | 2012-02-09 | Cardiac Pacemakers, Inc. | System and method for securing a lead in a vessel |
-
2007
- 2007-01-30 US US11/668,834 patent/US7917230B2/en not_active Expired - Fee Related
-
2008
- 2008-01-22 EP EP08728075A patent/EP2114513A1/en not_active Withdrawn
- 2008-01-22 WO PCT/US2008/051700 patent/WO2008094789A1/en active Application Filing
- 2008-01-22 JP JP2009547380A patent/JP2010516405A/ja active Pending
- 2008-01-22 CN CNA2008800034797A patent/CN101600470A/zh active Pending
- 2008-01-22 AU AU2008210862A patent/AU2008210862B2/en not_active Ceased
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2011
- 2011-03-07 US US13/041,834 patent/US8412350B2/en active Active
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Also Published As
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AU2008210862B2 (en) | 2011-12-01 |
WO2008094789A1 (en) | 2008-08-07 |
EP2114513A1 (en) | 2009-11-11 |
US8412350B2 (en) | 2013-04-02 |
JP2010516405A (ja) | 2010-05-20 |
US7917230B2 (en) | 2011-03-29 |
US20110152877A1 (en) | 2011-06-23 |
AU2008210862A1 (en) | 2008-08-07 |
US20080183253A1 (en) | 2008-07-31 |
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