CN101792415A - 低吸湿性阿立哌唑药物及其制备方法 - Google Patents
低吸湿性阿立哌唑药物及其制备方法 Download PDFInfo
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- CN101792415A CN101792415A CN200910266341A CN200910266341A CN101792415A CN 101792415 A CN101792415 A CN 101792415A CN 200910266341 A CN200910266341 A CN 200910266341A CN 200910266341 A CN200910266341 A CN 200910266341A CN 101792415 A CN101792415 A CN 101792415A
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- aripiprazole
- crystallization
- acid anhydride
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Abstract
Description
样品 | 最初湿含量(%) | 24小时后的湿含量(%) |
参比实施例1 | 0.04 | 3.28 |
参比实施例2 | 0.04 | 1.78 |
实施例2 | 0.04 | 0.04 |
实施例3 | 0.02 | 0.02 |
实施例4 | 0.02 | 0.02 |
实施例5 | 0.04 | 0.04 |
实施例6 | 0.04 | 0.04 |
实施例7 | 0.04 | 0.03 |
实施例8 | 0.04 | 0.03 |
实施例9 | 0.03 | 0.01 |
实施例10 | 0.05 | 0.05 |
实施例11 | 0.03 | 0.03 |
实施例12 | 0.04 | 0.03 |
实施例13 | 0.04 | 0.03 |
实施例14 | 0.06 | 0.09 |
实施例15 | 0.04 | 0.04 |
所用样品 | 最初 | 2周后 |
实施例19-a)的片剂(30mg) | 89.8% | 66.9% |
实施例19-b)的片剂(30mg) | - | 79.8% |
实施例19-c)的片剂(30mg) | - | 85.9% |
所用样品 | 最初 | 2周后 |
实施例18-a)的片剂(30mg) | 94.8% | 94.7% |
实施例20的片剂(30mg) | 93.7% | 93.1% |
所用样品 | 最初 | 2周后 |
实施例21的片剂(30mg) | 94.8% | 90.9% |
所用样品 | 最初 | 1周后 |
实施例22-d)的片剂(30mg) | 96.5% | 84.5% |
实施例22-e)的片剂(30mg)(干燥2小时) | 92.5% | 74.4% |
实施例22-e)的片剂(30mg)(干燥6小时) | 96.2% | 83.4% |
Claims (24)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001-290645 | 2001-09-25 | ||
JP2001290645 | 2001-09-25 | ||
JP2001348276 | 2001-11-14 | ||
JP2001-348276 | 2001-11-14 | ||
CA2379005 | 2002-03-27 | ||
CA 2379005 CA2379005A1 (en) | 2001-09-25 | 2002-03-27 | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN02801754A Division CN1463191A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101792415A true CN101792415A (zh) | 2010-08-04 |
Family
ID=27171631
Family Applications (16)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008101254103A Expired - Fee Related CN101434574B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2008101254090A Expired - Fee Related CN101434573B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2009101474930A Expired - Fee Related CN101579344B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2009101474907A Expired - Fee Related CN101574347B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN201610811822.7A Pending CN106420627A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN200910266341A Pending CN101792415A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2009101474926A Expired - Fee Related CN101579343B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN02801754A Pending CN1463191A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CNA2008101254118A Pending CN101434575A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CNA2008101254086A Pending CN101423493A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2009101474911A Expired - Fee Related CN101574348B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2008101254071A Expired - Fee Related CN101423492B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN201710019464.0A Pending CN106692151A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CNA2005100785991A Pending CN1699346A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN201610811281.8A Pending CN106420640A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN200610006215XA Expired - Lifetime CN1817882B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
Family Applications Before (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008101254103A Expired - Fee Related CN101434574B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2008101254090A Expired - Fee Related CN101434573B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2009101474930A Expired - Fee Related CN101579344B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2009101474907A Expired - Fee Related CN101574347B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN201610811822.7A Pending CN106420627A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
Family Applications After (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009101474926A Expired - Fee Related CN101579343B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN02801754A Pending CN1463191A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CNA2008101254118A Pending CN101434575A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CNA2008101254086A Pending CN101423493A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2009101474911A Expired - Fee Related CN101574348B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN2008101254071A Expired - Fee Related CN101423492B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN201710019464.0A Pending CN106692151A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CNA2005100785991A Pending CN1699346A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN201610811281.8A Pending CN106420640A (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
CN200610006215XA Expired - Lifetime CN1817882B (zh) | 2001-09-25 | 2002-09-25 | 低吸湿性阿立哌唑药物及其制备方法 |
Country Status (23)
Country | Link |
---|---|
US (20) | US20040058935A1 (zh) |
EP (6) | EP1330249B1 (zh) |
JP (3) | JP3760264B2 (zh) |
CN (16) | CN101434574B (zh) |
AR (2) | AR033485A1 (zh) |
AT (5) | ATE464050T1 (zh) |
AU (1) | AU2002334413C1 (zh) |
BR (1) | BR0205391A (zh) |
CA (6) | CA2688915C (zh) |
CY (1) | CY1118195T1 (zh) |
DE (5) | DE60210409T2 (zh) |
DK (5) | DK1927356T3 (zh) |
ES (5) | ES2343602T3 (zh) |
HU (1) | HUP0600141A3 (zh) |
IL (3) | IL153838A0 (zh) |
MX (1) | MXPA03000440A (zh) |
NO (7) | NO328134B1 (zh) |
PE (1) | PE20090124A1 (zh) |
PL (1) | PL225415B1 (zh) |
PT (5) | PT1927355E (zh) |
SI (4) | SI1927356T1 (zh) |
UA (1) | UA84764C2 (zh) |
WO (1) | WO2003026659A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102060763A (zh) * | 2010-12-27 | 2011-05-18 | 齐鲁制药有限公司 | 微粉型阿立哌唑晶型ⅰ或ⅱ的制备方法 |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7053092B2 (en) | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
AR032641A1 (es) * | 2001-01-29 | 2003-11-19 | Otsuka Pharma Co Ltd | Agonista de subtipo de receptor 5-ht 1a. |
AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
ES2322953T3 (es) | 2002-08-20 | 2009-07-02 | Bristol-Myers Squibb Company | Formulacion del complejo de aripiprazol y procedimiento. |
US20040185110A1 (en) * | 2002-11-08 | 2004-09-23 | Ronald Harland | Formulations of low solubility bioactive agents and processes for making the same |
AR042806A1 (es) * | 2002-12-27 | 2005-07-06 | Otsuka Pharma Co Ltd | Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo |
ATE376419T1 (de) | 2002-12-27 | 2007-11-15 | Otsuka Pharma Co Ltd | Carbostyril-derivate mit selektiven serotonin- aufnahme inhibitoren, zur behandlung von gemütskrankheiten |
ATE308524T1 (de) † | 2003-01-09 | 2005-11-15 | Otsuka Pharma Co Ltd | Verfahren zur herstellung von aripiprazole |
US20060270683A1 (en) * | 2003-04-25 | 2006-11-30 | Lohray Braj B | Polymorphs of aripiprazole |
ES2609382T3 (es) | 2003-05-23 | 2017-04-20 | Otsuka Pharmaceutical Co., Ltd. | Derivados de carboestirilo y estabilizadores del estado de ánimo para tratar los trastornos del estado de ánimo |
AU2003259545A1 (en) * | 2003-07-25 | 2005-02-14 | Hetero Drugs Limited | Aripiprazole crystalline forms |
UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
UA82561C2 (uk) * | 2003-10-23 | 2008-04-25 | Оцука Фармасьютикалз Ко., Лтд. | Стерильна ін'єкційна композиція арипіпразолу з контрольованим вивільненням, спосіб її виготовлення та спосіб лікування шизофренії |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102060763A (zh) * | 2010-12-27 | 2011-05-18 | 齐鲁制药有限公司 | 微粉型阿立哌唑晶型ⅰ或ⅱ的制备方法 |
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Correction item: Inventor Correct: Tomikawa Kenji|Takahashi Masanori|Abe Kaoru|Shi Shangcheng|Shinhama Koichi|Cou Neigang|Teng Bensheng|Oi Yoshihiro|Yamada Shohei|Teng Cunqin|Kawasaki Junichi|A Buxun|Taniguchi Youichi|Yabuuchi Tsuyoshi|Fujimoto Kiyoshi|Nishioka Yoshihiro|Kobayashi Noriyuki|Fujimura Tsutomu|Bando Takuji False: Tomikawa Kenji|Takahashi Masanori|Abe Kaoru|Shi Shangcheng|Shinhama Koichi|Cou Neigang|Teng Bensheng|Oi Yoshihiro|Yamada Shohei|Kawasaki Junichi|A Buxun|Taniguchi Youichi|Yabuuchi Tsuyoshi|Fujimoto Kiyoshi|Nishioka Yoshihiro|Kobayashi Noriyuki|Fujimura Tsutomu|Bando Takuji Number: 31 Volume: 26 |
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Correction item: Inventor Correct: Tomikawa Kenji|Takahashi Masanori|Abe Kaoru|Shi Shangcheng|Shinhama Koichi|Cou Neigang|Teng Bensheng|Oi Yoshihiro|Yamada Shohei|Teng Cunqin|Kawasaki Junichi|A Buxun|Taniguchi Youichi|Yabuuchi Tsuyoshi|Fujimoto Kiyoshi|Nishioka Yoshihiro|Kobayashi Noriyuki|Fujimura Tsutomu|Bando Takuji False: Tomikawa Kenji|Takahashi Masanori|Abe Kaoru|Shi Shangcheng|Shinhama Koichi|Cou Neigang|Teng Bensheng|Oi Yoshihiro|Yamada Shohei|Kawasaki Junichi|A Buxun|Taniguchi Youichi|Yabuuchi Tsuyoshi|Fujimoto Kiyoshi|Nishioka Yoshihiro|Kobayashi Noriyuki|Fujimura Tsutomu|Bando Takuji Number: 31 Page: The title page Volume: 26 |
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