CN103454364A - Chromatographic column device for generator - Google Patents
Chromatographic column device for generator Download PDFInfo
- Publication number
- CN103454364A CN103454364A CN201210166875XA CN201210166875A CN103454364A CN 103454364 A CN103454364 A CN 103454364A CN 201210166875X A CN201210166875X A CN 201210166875XA CN 201210166875 A CN201210166875 A CN 201210166875A CN 103454364 A CN103454364 A CN 103454364A
- Authority
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- China
- Prior art keywords
- plug
- glass
- generator
- chromatographic column
- silicone tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000011521 glass Substances 0.000 claims abstract description 42
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 22
- 239000003463 adsorbent Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 6
- 238000005245 sintering Methods 0.000 claims description 3
- 238000010828 elution Methods 0.000 description 10
- 229910001220 stainless steel Inorganic materials 0.000 description 8
- 239000010935 stainless steel Substances 0.000 description 8
- 239000004568 cement Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000012217 radiopharmaceutical Substances 0.000 description 3
- 229940121896 radiopharmaceutical Drugs 0.000 description 3
- 230000002799 radiopharmaceutical effect Effects 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 229960001866 silicon dioxide Drugs 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical group O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
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Abstract
The invention discloses a chromatographic column device for a generator, which mainly comprises a glass column, a rubber plug and a silicone tube, wherein the rubber plug and the silicone tube are of an integrated structure. The chromatographic column device for the generator has a simple structure, reduces air leakage points and dead angles of the device, and improves the product quality.
Description
Technical field
The present invention relates to the radiological measuring technical field, particularly a kind of device of the chromatographic column for generator.
Background technology
Generator is radiopharmaceutic loading attachment, is also the main source of Radionuclide imaging medicine, at medical detection field, occupies critical role.At present both at home and abroad generator is mainly by external packing body, protective device and inner chromatographic column installation composition, the chromatographic column device be its most core be also of paramount importance part.The generator interior arrangement roughly is comprised of cylinder and the various coupling arrangement of adsorbent, carrying adsorbent.The selection of adsorbent is generally according to the type of generator and the adsorptive power of radiopharmaceutical parent is chosen to suitable adsorbent; The cylinder of carrying adsorbent generally adopts glass column, also has the part generator to select the cylinder of other materials, and its shape, size have difference according to the mode of production separately and the difference of technological process; In the selection of coupling arrangement parts, external generator generally selects stainless steel as connecting material.
The original chromatographic column device of applicant (as shown in Figure 2) by glass column, 2 plug plugs, 2 stainless steel elbows, two silicone tubes totally 7 parts form, complex structure and find to have following major defect in the application of more than 10 years: 1 building block is many, manufacture craft is loaded down with trivial details, the problem that simultaneously also may cause device gas leakage that generator can't normally be used; 2 tie points are more many more easily to be formed and cleans dead angle, brings the probability of bacteria breed hidden danger just larger; 3 are unfavorable for sterilization: what original device was used is the medical stainless steel that model is 0 chromium 18 nickel 11 titaniums, and it is disinfected and need in ultrasonic cleaner, use HNO
3impurity is removed in washing, then with dish detergent, carries out oil removal treatment, and finally under 180 ℃ of high temperature, sterilization just can reach sterilization effect in 2 hours.
The external stainless steel that adopts as main coupling arrangement more, there is defect on the apparatus system impermeability, and we once tested trial use stainless steel as main coupling arrangement, but because the stainless steel quality is uneven, cross section is cast aside some stainless steel inside of rear discovery and be there will be dark oil to fail to understand material, be difficult to clean, can not arrive medical standard, and after using, generator elution efficiency abnormal occurrence appears in occasional; And there is nitric acid drip washing step in the chromatographic column manufacture craft, if adopt stainless steel for connecting main body, have high volence metal ion to enter in adsorbent, affect the elution efficiency of generator.
Summary of the invention
The present invention has overcome deficiency of the prior art, provides a kind of simple in structure, reduces device gas leakage point and dead angle, the device of the chromatographic column for generator improved the quality of products.
In order to solve the problems of the technologies described above, the present invention is achieved by the following technical solutions:
A kind of device of the chromatographic column for generator, mainly be comprised of glass column, plug plug, silicone tube, and key is, described plug plug and silicone tube are the integral type structure.
The present invention is all right:
Described plug plug and silicone tube are pressed into integral structure through press mold technique.
Described press mold technique is carried out under the condition of 160 ℃～180 ℃.
Described glass column is cylindrical, the built-in glass core in middle and lower part, and glass core and cylinder sintering form, and on the glass core, arrange adsorbent, cover layer of glass on adsorbent.
Compared with prior art, the invention has the beneficial effects as follows:
Plug plug and silicone tube adopt the structure of integral type, tie point and the dead angle of device are reduced, reduced the hidden danger that bacteria breed brings, make device safer, the product quality of producing is guaranteed, and, in the radiopharmaceutical production technology, safety is priority for the technician always, therefore the invention solves those of ordinary skill and thirst for the high safety reliability problem solved always.Simultaneously, the present invention has overcome the abnormal problem of elution efficiency, guarantees product percent of pass, has reduced unnecessary loss, has also greatly reduced the problem that it can't be used due to device gas leakage.
The accompanying drawing explanation
Fig. 1 chromatographic column device schematic diagram
The original chromatographic column device of Fig. 2 schematic diagram
Fig. 3 elution efficiency curve map
Silicone tube, 2 top cement plug plugs, 3 glass columns, 4 glass cores, 5 adsorbents, 6 bottom plug plugs, 7 times silicone tubes on 1.
Embodiment
Below in conjunction with accompanying drawing and embodiment, the present invention is described in further detail:
A kind of device of the chromatographic column for generator as shown in Figure 1, mainly by glass column 3, plug plug, silicone tube, formed, glass column 3 is cylindrical, glass core 4 is placed in middle and lower part, integral body is seamless ring body, arrange adsorbent 5 on glass core 4, on adsorbent 5, cover layer of glass, glass fibre has prevented that adsorbent 5 from disorderly flying in lessivation everywhere.Wherein the plug plug is divided into upper and lower two, is used for being arranged on glass column 3 two ends; Silicone tube also is divided into upper and lower two, and plug plug and silicone tube are the integral type structure, that is to say, top cement plug plug 2 and upper silicone tube 1 are the integral type structure, and bottom plug plug 6 and lower silicone tube 7 are the integral type structure.The structure of described plug plug and silicone tube integral type can be pressed into one through press mold technique at 160 ℃～180 ℃ by medical silica-gel and medical silica-gel plug and form.
Glass column 3 is cylindrical, and glass core 4 is placed in middle and lower part, and the cylinder sizes of the more existing device of cylinder design is smaller, and glass column 3 thickness do not become, and has improved the firm degree of glass column 3 devices, is that outward appearance is more exquisite, attractive in appearance.Glass column 3 can be made by glass core 4 and glass tube sintering.Silica gel pipe close mouth has certain shrink tension, it is filled in to 3 mouthfuls of glass columns and can make it smooth all the time, and seamless is combined with glass column 3 inwalls.Top cement plug plug 2 is connected to the top (away from glass core 4) of glass column 3, and bottom plug plug 6 is connected to the below of glass column 3.
When in production work, use is of the present invention, radiopharmaceutical
99mo is entered in glass column 3 by upper silicone tube 1 and top cement plug plug 2 by the system negative pressure, is adsorbed in the Al of carrying in glass column 3
2o
3on adsorbent 5, glass column 3 is selected wall thickness 1.5mm, internal diameter 6mm, and in glass column 3, glass core 4 is for intercepting the Al of carrying
2o
3 adsorbent 5 leaked, and the liquid after absorption flows out through bottom plug plug 6 and lower silicone tube 7, enters refuse and takes up system.
User (hospital) uses when of the present invention, and leacheate enters glass column 3 by upper silicone tube 1 and top cement plug plug 2, and the medicine drip washing generated in glass column 3 is got off, and flows out to enter in negative pressure bottle through bottom plug plug 6 and lower silicone tube 7 and collects, for patient.
Be illustrated in figure 3 the elution efficiency curve map of generator, obvious peak value should appear in normal elution efficiency curve before certain elution volume, abnormal elution efficiency curve does not have rule to follow, the leacheate measured value is lower and fluid, can cause reaching medicine video picture concentration, can't the bio-occlusion patient use.Adopt generator elution efficiency curve of the present invention to be the normal elution efficiency curve shown in Fig. 3.
Claims (4)
1. the device of the chromatographic column for generator, mainly be comprised of glass column, plug plug, silicone tube, it is characterized in that, described plug plug and silicone tube are the integral type structure.
2. a kind of device of the chromatographic column for generator according to claim 1, is characterized in that, described plug plug and silicone tube are pressed into integral structure through press mold technique.
3. a kind of device of the chromatographic column for generator according to claim 2, is characterized in that, described press mold technique is carried out under the condition of 160 ℃～180 ℃.
4. a kind of device of the chromatographic column for generator according to claim 1, is characterized in that, described glass column is cylindrical, the built-in glass core in middle and lower part, glass core and cylinder sintering form, and on the glass core, arrange adsorbent, cover layer of glass on adsorbent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210166875.XA CN103454364B (en) | 2012-05-28 | 2012-05-28 | Chromatographic column device for generator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210166875.XA CN103454364B (en) | 2012-05-28 | 2012-05-28 | Chromatographic column device for generator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103454364A true CN103454364A (en) | 2013-12-18 |
| CN103454364B CN103454364B (en) | 2015-12-09 |
Family
ID=49736968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210166875.XA Active CN103454364B (en) | 2012-05-28 | 2012-05-28 | Chromatographic column device for generator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103454364B (en) |
Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0102121A1 (en) * | 1982-08-26 | 1984-03-07 | Mallinckrodt Diagnostica (Holland) B.V. | Shielding device for a reservoir comprising a radioactive material |
| US5109160A (en) * | 1990-10-12 | 1992-04-28 | E. I. Du Pont De Nemours And Company | Sterilizable radionuclide generator and method for sterilizing the same |
| US5186913A (en) * | 1991-04-26 | 1993-02-16 | Martin Marietta Energy Systems, Inc. | Tungsten-188/carrier-free rhenium-188 perrhenic acid generator system |
| CN1085517A (en) * | 1992-10-14 | 1994-04-20 | 中国核动力研究设计院 | Automatic loading apparatus for gel type Tc-99 m generator |
| EP0624795A2 (en) * | 1993-05-14 | 1994-11-17 | Upchurch Scientific, Inc. | Column for liquid chromatography |
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| US20080035542A1 (en) * | 2006-08-14 | 2008-02-14 | Board Of Regents, The University Of Texas System | Automated system for formulating radiopharmaceuticals |
| EP1933331A2 (en) * | 2006-12-12 | 2008-06-18 | Isotopen Technologien München AG | Column system for creating a solution with high specific activity |
| CN101329312A (en) * | 2008-07-31 | 2008-12-24 | 浙江大学 | Chromatographic column |
| CN101716429A (en) * | 2008-10-09 | 2010-06-02 | 天津博纳艾杰尔科技有限公司 | Medium pressure chromatogram purification column |
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| WO2011106847A1 (en) * | 2010-03-03 | 2011-09-09 | Australian Nuclear Science And Technology Organisation | Sorbent material |
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| US20120011965A1 (en) * | 2010-07-14 | 2012-01-19 | Ming-Hsin Li | Gallium-68 radioisotope generator and generating method thereof |
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-
2012
- 2012-05-28 CN CN201210166875.XA patent/CN103454364B/en active Active
Patent Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0102121A1 (en) * | 1982-08-26 | 1984-03-07 | Mallinckrodt Diagnostica (Holland) B.V. | Shielding device for a reservoir comprising a radioactive material |
| US5109160A (en) * | 1990-10-12 | 1992-04-28 | E. I. Du Pont De Nemours And Company | Sterilizable radionuclide generator and method for sterilizing the same |
| US5186913A (en) * | 1991-04-26 | 1993-02-16 | Martin Marietta Energy Systems, Inc. | Tungsten-188/carrier-free rhenium-188 perrhenic acid generator system |
| CN1085517A (en) * | 1992-10-14 | 1994-04-20 | 中国核动力研究设计院 | Automatic loading apparatus for gel type Tc-99 m generator |
| EP0624795A2 (en) * | 1993-05-14 | 1994-11-17 | Upchurch Scientific, Inc. | Column for liquid chromatography |
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| CN1658938A (en) * | 2002-04-12 | 2005-08-24 | Pg研究基金会公司 | Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine |
| CN101013116A (en) * | 2006-01-31 | 2007-08-08 | 科诺华公司 | Reusable liquid chromatographic columns |
| US20080035542A1 (en) * | 2006-08-14 | 2008-02-14 | Board Of Regents, The University Of Texas System | Automated system for formulating radiopharmaceuticals |
| EP1933331A2 (en) * | 2006-12-12 | 2008-06-18 | Isotopen Technologien München AG | Column system for creating a solution with high specific activity |
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| US20110049030A1 (en) * | 2009-09-02 | 2011-03-03 | Agilent Technologies, Inc. | Chromatography Column With Large Diameter End Fitting Openings |
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| US20120011965A1 (en) * | 2010-07-14 | 2012-01-19 | Ming-Hsin Li | Gallium-68 radioisotope generator and generating method thereof |
| CN201993349U (en) * | 2011-03-17 | 2011-09-28 | 中华人民共和国绍兴出入境检验检疫局 | Semi-automatic gel permeation purification device |
| CN202583145U (en) * | 2012-05-28 | 2012-12-05 | 原子高科股份有限公司 | Chromatographic column device for generator |
Non-Patent Citations (4)
| Title |
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| CN103454364B (en) | 2015-12-09 |
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