CN104382676A - In-vivo wireless communication device based on vascular stent and wireless communication system - Google Patents
In-vivo wireless communication device based on vascular stent and wireless communication system Download PDFInfo
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- CN104382676A CN104382676A CN201410677515.5A CN201410677515A CN104382676A CN 104382676 A CN104382676 A CN 104382676A CN 201410677515 A CN201410677515 A CN 201410677515A CN 104382676 A CN104382676 A CN 104382676A
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Abstract
The invention discloses an in-vivo wireless communication device based on a vascular stent and a wireless communication system. The in-vivo wireless communication device comprises the vascular stent and a trigger circuit mounted on the vascular stent, the trigger circuit is used for acquiring health condition data related to vascular diseases and/or providing in-vivo therapy related to the vascular diseases, an output of the trigger circuit is fed to the vascular stent, the vascular stent serves as an antenna to transmit wireless signals outwards, and the vascular stent further serves as the antenna to receive wireless signals in vitro and transmit the wireless signals to the trigger circuit. A special antenna structure does not need to be arranged in a blood vessel, the in-vivo wireless communication device is small in size, and the blood vessel can be monitored and treated in real time at low cost.
Description
Technical field
The present invention relates to a kind of based on radio communication device and wireless communication system in the body of intravascular stent.
Background technology
Intravascular stent refers on the basis of tube chamber balloon expandable molding, implant in lesion locations, stenosis occlusion section blood vessel is supported in order to reach, minimizing blood vessel elasticity retraction and again plasticity, keep the supporting structure of the object that tube chamber blood flow is unobstructed, be mainly divided into coronary stent, cerebrovascular support, renal artery stent, aortic stent etc.The material being usually used in making support at present comprises metal tantalum, medical stainless steel, Nitinol etc.
By 2013, China's cardiovascular patient reached 2.5 hundred million people, every year because patient's number of cardiovascular death reaches 3,000,000 people.In cardiovascular disease, the M & M of coronary heart disease is high, increases very fast.Since 2005, the overall fashion trend of China's cardiovascular disease is unanimously in rising situation, and town and country situation is similar.In patients with coronary heart disease, have an appointment 20% patient be applicable to support intervene operation.Intervention support is performed the operation relative conventional medicament, the advantages such as surgical operation therapy method, has wound little, and anesthesia scope is little, and medical effect is remarkable.China in 2013 annual cardiovascular thromboembolism intervention support operation reaches 600,000 examples, and remains the growth rate of annual more than 35%.
But individual month of 6-8 after intervention support treatment, may there is cardiovascular restenosis in patient's implant frame position, situation about blocking even again.Use in the patient of metal rack, 20% may there is restenosis, and uses in the patient of drug stent, and the patient of 9% may occur restenosis.Restenosis with block and will seriously undermine operative effect again, even threat patient vitals safety.
In order to monitoring patients Vascular Restenosis after Balloom situation, check method main is at present thermal imaging, ultrasoundcardiogram, visualization, CT etc.But these method relative costs are higher, and apparatus is complicated, need patient to check in hospital.Nearly one or two years, research worker proposes to utilize for this type of situation installs velocity of blood flow in cardiovascular, and the methods such as pressure transducer are real-time, the method for cardiovascular examination easily.The miniature therapeutic equipment of implantation even can be utilized to clear up in time for the thrombosis occurred.But power supply, the communication means of this type of miniature vascular device effectively solve not yet, especially need Ink vessel transfusing be micromodule equipment, sensor arranges special antenna and power supply unit.
Summary of the invention
Main purpose of the present invention is for the deficiencies in the prior art, provides a kind of based on radio communication device and wireless communication system in the body of intravascular stent.
For this reason, the present invention is by the following technical solutions:
A kind of based on radio communication device in the body of intravascular stent, comprise intravascular stent and be arranged on the circuits for triggering on described intravascular stent, described circuits for triggering are for gathering the health status data relevant with angiopathy and/or providing the interior therapeutic relevant with angiopathy, the output of described circuits for triggering is fed to described intravascular stent and outwards sends wireless signal using described intravascular stent as antenna, and described intravascular stent also receives exogenic wireless signal as antenna and is supplied to described circuits for triggering.
Further:
Also comprise feeder line, described circuits for triggering connect described intravascular stent by described feeder line.
Described feeder line is welded on described intravascular stent by solder joint.
Described circuits for triggering being coated with biology can compatible shell.
Preferably, described shell is polydimethyl siloxane material.
Described feeder line is that biology can compatible metal material, and wrapping biological is gone back in preferred outside can compatible film.
Described feeder line and described intravascular stent weld are coated with biology can compatible film.
Preferably, solder joint is the solder soldering formation of 80 % by weight gold medals and 20 % by weight stannum.
Described intravascular stent is that biology can the cylindrical shape network structure of compatible metal material.
Described circuits for triggering are integrated on single silicon chip.
The wireless signal that described intravascular stent receives is driving electric energy and/or the control signal of sensor and/or miniature therapeutic equipment in described circuits for triggering internal conversion.
Based on a radio communication device in the body of intravascular stent, to comprise in described body radio communication device and carry out the external communicator of radio communication with radio communication device in described body.
Beneficial effect of the present invention:
Circuits for triggering as the antenna that can use at people's et al. Ke, are arranged on blood stent, can reaching the wireless data transmission of carrying out with outside by the present invention by blood stent, for circuits for triggering provide the object of control signal and energy supply.The present invention is without the need to special antenna structure, volume is little, can easily with Wicresoft's intervene operation implant into body, and low cost, the monitoring of real-time blood vessel and treatment can be realized, be conducive to patient and healthcare givers finds in time fast, treats the symptoms such as vascular restenosis.
Accompanying drawing explanation
Fig. 1 is the structural representation of the wireless communication system that the present invention is based on intravascular stent;
Fig. 2 is the side-looking structural representation based on radio communication device in the body of intravascular stent of the embodiment of the present invention.
Detailed description of the invention
Below embodiments of the present invention are elaborated.It is emphasized that following explanation is only exemplary, instead of in order to limit the scope of the invention and apply.
Consult Fig. 1 and Fig. 2, according to embodiments of the invention, the wireless communication system based on intravascular stent comprises communicator 1001 and external communicator 1002 in body, and both carry out radio communication by the intravascular stent of the antenna as communicator in body 1001.
In body, communicator 1001 comprises circuits for triggering 2001 and intravascular stent 2004, those skilled in the art can understand, wherein intravascular stent 2004 is as structural metallic materials (tubular network structure as shown in Figure 2), may be used for transmitting and receiving the wireless signal with certain frequency range of its shape, matching size, for realizing radio communication, it is consistent with the frequency range of intravascular stent antenna with the communications band of external communicator that communicator in body can be set.Circuits for triggering 2001 can be connected with feeder line 2002, and feeder line 2002 can be welded with intravascular stent 2004 by solder joint 2003, to realize radiofrequency signal to send to human body from intravascular stent 2004.Circuits for triggering 2001 can comprise radio transceiver circuitry, rectification circuit, electric power management circuit, sensor interface circuitry and various sensor, as micro-electromechanical pressure transducer etc.These circuit design often occur in low-power consumption RFID designs, and belong to mature technology, therefore repeat no more.Circuits for triggering 2001 can utilize 130nm CMOS technology to be integrated on a rectangular silicon substrate.Preferably, circuits for triggering 2001 can have biology can compatible shell.Such as, it is 1mm that the rectangular silicon substrate made can be positioned over the degree of depth, and the length of side is greater than the mould central authorities of silicon chip 0.1mm, and utilizing polydimethylsiloxane to wrap up and add thermosetting biology can compatible shell.The radio transceiver circuitry of circuits for triggering 2001 connects feeder line 2002, and feeder line 2002 can be made up by compatible metal material of the biology such as medical stainless steel, Nitinol, outside also alternative wrapping biological can compatible film to improve biological compatibility further.Feeder line 2002 is connected on intravascular stent 2004 by solder joint.Solder joint 2003 can be formed by the solder soldering of 80% gold medal and 20% stannum.Preferably, weld sprays one deck biology can compatible film, reaches better bio-compatibility.
External communicator 1002 can comprise radio transceiver circuitry, wireless charging signal transmission circuit, data processing circuit, display circuit and some buttons.
In the process of a data communication, external communicator 1002 is launched radio frequency signal and is penetrated human body 1000, and intravascular stent 2004 forms the signal of telecommunication.In body, communicator 1001 receives the signal of telecommunication that intravascular stent 2004 is formed, and produces firm power export to supply intravascular sensors (as velocity of blood flow sensor, pressure transducer), miniature therapeutic equipment etc. by rectification circuit.After equipment obtains the control data in the signal of telecommunication in body, perform corresponding operating, such as, the micro-electro-mechanical sensors that in body, communicator 1001 is built-in and miniature therapeutic equipment can the interior data relevant with human health status of acquisition volume.Micro-electromechanical pressure transducer can communicator 1001 extracts intravascular stent in vivo signal energy start when being not less than 1mW.The data that sensor produces, can be generated as radiofrequency signal by modulation in communicator 1001 in vivo.Such as, sensor exports variable voltage value, and magnitude of voltage is after the analog to digital conversion of sensor interface circuitry, radiofrequency signal is become through two-way phase shift keying modulation, be antenna transmission radiofrequency signal with intravascular stent 2004, radiation penetrates human body 1000, arrives external communicator 1002.
External communicator 1002 demodulation radiofrequency signal, through Data correction, shows after process.Modulation system includes but not limited to: two-way frequency shift keying, two-way phase-shift keying etc.Such as, external communicator 1002 receives and is taken out by pressure value after restituted signal, by the restenosis situation of related algorithm monitoring blood vessel.
In an exemplary embodiment, radio frequency signal used is in the ISM band comprising international endorsement, the medical implant device frequency range etc. that ACA specifies.Concrete frequency range determines according to intravascular stent 2004 size.External communication module is with the power meeting international human body 1000 microwave illumination and specify and distance, and such as distance human body 10cm, power 3.5W, launch 433MHz radiofrequency signal.
In body, communicator 1001 is fixed on intravascular stent 2004 by solder joint 2003.To the intravascular stent 2004 of communicator 1001 in body be welded with normal intervene operation patients with implantation Ink vessel transfusing.Such as, in Wicresoft's intervene operation, together implant precalculated position as abdominal aorta otch with tubule and intravascular stent 2004 from human body 1000 blood vessel somewhere.
The sensor implanted includes but not limited to: utilize the piezoelectric pressure indicator that micro-electromechanical technology is processed, capacitance pressure transducer, heat diffusion formula flow sensor, temperature sensor, blood oxygen transducer etc.Sensor is installed in circuits for triggering 2001, is installed in also to comprise sensor interface circuitry, electric power management circuit etc. in circuits for triggering 2001 simultaneously.Sensor operation energy obtains by signal of telecommunication rectification, thus saves special power supply unit.
Above content combines concrete/preferred embodiment further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention; without departing from the inventive concept of the premise; its embodiment that can also describe these makes some substituting or modification, and these substitute or variant all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. one kind based on radio communication device in the body of intravascular stent, it is characterized in that, comprise intravascular stent and be arranged on the circuits for triggering on described intravascular stent, described circuits for triggering are for gathering the health status data relevant with angiopathy and/or providing the interior therapeutic relevant with angiopathy, the output of described circuits for triggering is fed to described intravascular stent and outwards sends wireless signal using described intravascular stent as antenna, and described intravascular stent also receives exogenic wireless signal to be transported to described circuits for triggering as antenna.
2. radio communication device in body as claimed in claim 1, it is characterized in that, also comprise feeder line, described circuits for triggering connect described intravascular stent by described feeder line.
3. radio communication device in body as claimed in claim 2, it is characterized in that, described feeder line is welded on described intravascular stent by solder joint.
4. radio communication device in the body as described in any one of claims 1 to 3, is characterized in that, described circuits for triggering being coated with biology can compatible shell, and preferably, described shell is polydimethyl siloxane material.
5. radio communication device in the body as described in any one of claim 2 to 3, is characterized in that, described feeder line is that biology can compatible metal material, and wrapping biological is gone back in preferred outside can compatible film.
6. radio communication device in body as claimed in claim 3, is characterized in that, described feeder line and described intravascular stent weld are coated with biology can compatible film, and preferred solder joint is the solder soldering formation of 80 % by weight gold medals and 20 % by weight stannum.
7. radio communication device in the body as described in any one of claim 1 to 6, is characterized in that, described intravascular stent is that biology can the cylindrical shape network structure of compatible metal material.
8. radio communication device in the body as described in any one of claim 1 to 6, is characterized in that, described circuits for triggering are integrated on single silicon chip.
9. radio communication device in the body as described in any one of claim 1 to 6, is characterized in that, the wireless signal that described intravascular stent receives is driving electric energy and/or the control signal of sensor and/or miniature therapeutic equipment in described circuits for triggering internal conversion.
10. based on a radio communication device in the body of intravascular stent, it is characterized in that, to comprise in the body described in any one of claim 1 to 9 radio communication device and carry out the external communicator of radio communication with radio communication device in described body.
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| CN105832318A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Renal arterial stent based pressure difference monitoring device and renal arterial stent based pressure difference monitoring method |
| CN105832332A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Thoracic descending aorta stent based aneurysm impedance monitoring device and thoracic descending aorta stent based aneurysm impedance monitoring method |
| CN105832324A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Device and method for monitoring blood flow velocities on basis of abdominal aortic stent |
| CN105832312A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Device and method for monitoring blood rheology on basis of renal arterial stent |
| CN105832326A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Coronary stent based blood flow speed monitoring device and coronary stent based blood flow speed monitoring method |
| CN105832313A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Peripheral arterial stent based hemorheological monitoring device and peripheral arterial stent based hemorheological monitoring method |
| CN105832314A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Thoracic descending aorta stent based hemorheological monitoring device and thoracic descending aorta stent based hemorheological monitoring method |
| CN105832325A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Renal arterial stent based blood flow speed monitoring device and renal arterial stent based blood flow speed monitoring method |
| CN105832311A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Coronary stent based hemorheological monitoring device and coronary stent based hemorheological monitoring method |
| CN105868577A (en) * | 2016-06-06 | 2016-08-17 | 任勇 | Blood flow velocity monitoring device and method based on carotid artery stent |
| CN105852842A (en) * | 2016-06-06 | 2016-08-17 | 任勇 | Blood rheology monitoring device and method based on arteria femoralis stent |
| CN105902259A (en) * | 2016-06-06 | 2016-08-31 | 任勇 | Blood flow speed monitoring device and method based on femoral artery stent |
| CN105902260A (en) * | 2016-06-06 | 2016-08-31 | 任勇 | Hemorheology monitoring device and method based on abdominal aorta stent |
| CN105902261A (en) * | 2016-06-06 | 2016-08-31 | 任勇 | Blood flow speed monitoring device and method based on thoracic descending aorta stent |
| CN105919576A (en) * | 2016-06-06 | 2016-09-07 | 任勇 | Pressure difference monitoring device based on femoral artery stent and method based on pressure difference monitoring device |
| CN105919577A (en) * | 2016-06-06 | 2016-09-07 | 任勇 | Pressure difference monitoring device based on venous stent and method based on pressure difference monitoring device |
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| CN105919578A (en) * | 2016-06-06 | 2016-09-07 | 任勇 | Pressure difference monitoring device based on peripheral artery stent and method based on pressure difference monitoring device |
| CN105943007A (en) * | 2016-06-06 | 2016-09-21 | 任勇 | Pressure-difference monitoring device based on carotid artery stent and method thereof |
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| CN105832333A (en) * | 2016-06-06 | 2016-08-10 | 任勇 | Device and method for monitoring tumor impedance and blood flow rates on basis of abdominal aortic stent |
| CN108567511A (en) * | 2017-03-13 | 2018-09-25 | 上海微创医疗器械（集团）有限公司 | Stent system |
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