CN1052919C - Three-dimensional irradiation tech. and equipment with charged particle having Bragg peak character - Google Patents
Three-dimensional irradiation tech. and equipment with charged particle having Bragg peak character Download PDFInfo
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- CN1052919C CN1052919C CN97101188A CN97101188A CN1052919C CN 1052919 C CN1052919 C CN 1052919C CN 97101188 A CN97101188 A CN 97101188A CN 97101188 A CN97101188 A CN 97101188A CN 1052919 C CN1052919 C CN 1052919C
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- bragg peak
- illumination unit
- treatment
- irradiation
- charged particle
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Abstract
The present invention provides a three-dimensional irradiation technology and a device by utilizing Bragg peaks of charged particles. Bragg peak areas of the charged particles are selected to be irradiation units which rotate around a definite rotating shaft to form rotary irradiation units. Through a treatment planning system, the rotary irradiation units are used to fit the shape of a target region. The device of the present invention comprises an accelerator, a beam transport line, a magnet system, a beam switching device, a treatment head, a treatment couch, a treatment planning system and an electric control system, wherein the magnet system amplifies and shrinks beam spots; the treatment couch has five degrees of freedom. The treatment head comprises an achromatic magnet system, a beam energy regulating system, a collimator system, a dose monitoring system, etc.; the treatment head can swing around a central axis which is parallel to the ground and can stay at any angle.
Description
The present invention relates to field of radiation therapy, especially relate to the 3-dimensional irradiation technology and the device thereof of charged particle with Bragg peak character.
Charged particle with Bragg peak character comprises proton, light ion, heavy ion and pi-meson etc.So-called bragg peak is meant that after charged particle entered human body, its energy was slow in the tissue surface losses, is lost near its final on trajectory and concentrate, and forms a high ionization absworption peak in human body.Have the conventional radiotherapy of charged particle treatment of Bragg peak character, have higher accuracy, can treat near the focus the sensitive organization of health as electronics line, X ray etc.Have in the middle of the charged particle of Bragg peak character, carrying out in the world at present is proton therapeutic comparatively widely.Proton therapeutic mainly is to utilize its bragg peak to carry out the three-dimensional conformal treatment.The three-dimensional conformal treatment of so-called proton is meant, makes the shape and the shape fit of focus of the cross section of line, simultaneously the bragg peak of proton is modulated, make bragg peak regional longitudinally shape also with the shape fit of focus.Hans Blattmann is in the article " Therapy withMedium Energy Protons " of " Advanced Techniques for Radiotherapy " book of publication in 1992, summed up existing proton three-dimensional conformal technology, mainly contained two kinds: passive diffuse transmission type and scan-type initiatively.Diffuse transmission type is to be extended to an equally distributed line by scattering object through the line that accelerator is drawn in its horizontal vertical plane, again through collimating device collimation; Vertically bragg peak is being carried out broadening, thereby reaching three-dimensional conformal treatment the target area by regulating accelerator energy or increasing absorber.Scan-type is in horizontal vertical plane, by two mutually perpendicular two extremely ferromagnetic, line to be scanned to the target area; Vertically, by regulating beam energy, change the degree of depth of bragg peak, so in layer irradiation in fact also is equivalent to bragg peak is carried out broadening, thereby reaches the three-dimensional conformal treatment to the target area.As shown in Figure 1, abscissa is represented proton in the intravital degree of depth of people, and vertical coordinate is represented the relative dosage of proton in tissue; One bragg peak is very sharp-pointed, and the bragg peak of a plurality of different depths is superposeed, and then can obtain the bragg peak of broadening.Though the dose distribution of single bragg peak is better, through behind the vertical broadening to bragg peak, the dosage that the normal structure in the exposure pathways is subjected to will repeatedly superpose, and its suffered dosage also improves greatly.Therefore, when this two kind of proton three-dimensional conformal technology of use,, have to adopt interval procedure for avoiding that normal structure is caused excessive dosage.As shown in Figure 2, all adopt the scheme of turntable at present in the world basically than advanced proton therapeutic appts.Turntable 1 centers on 360 ° of rotations of human body, 360 ° of rotations of therapeutic bed 2 levels, and both combinations just can be in 4 π spaces from any angle incident focus.Generally in treatment, adopt 3～4 inlets to shine.Utilize the turntable technology,, in the irradiation of each inlet, still need the target area is carried out the irradiation of long period though can carry out the irradiation of multiple entry to the target area.Because device required in the turntable is more, turntable often makes very greatly, very heavy, and cost is very high.
It is better to the purpose of this invention is to provide a kind of dose distribution, utilizes the bragg peak of charged particle the target area to be carried out the technology of 3-dimensional irradiation; Another object of the present invention provides a kind of device of realizing this 3-dimensional irradiation technology, and this device and existing turntable scheme structure compared are simpler.
To achieve these goals, the present invention has adopted following technical scheme: the effective bragg peak zone of charged particle is chosen to be illumination unit, makes illumination unit around certain gyroaxis rotation, thereby form a rotary irradiation unit.By treatment planning systems, remove the match target region shape with rotary irradiation unit, thereby realize 3-dimensional irradiation the target area.
The inventive system comprises the accelerator that can produce charged particle with Bragg peak character, beam-flow transmission line, the halved tie speckle amplifies the magnet system of dwindling, line switching device, treatment head, therapeutic bed, treatment planning systems and electric control system.Wherein treatment head comprises magnet system, beam energy regulating system, the collimator system of regulating light spot shape and the dose monitoring system etc. that colour killing is loose, and the treatment head can be around the central shaft swing that is parallel to ground, and can rest on unspecified angle.Therapeutic bed comprises base, bed axle and bed body.Wherein, base comprises the guiding mechanism of directions X, can move along directions X; Bed axle comprises Z to elevating mechanism and rotating mechanism, can be along Z to lifting, and rotate around the Z axle; The bed body comprises the guiding mechanism of X and Y direction, can move along X and Y direction, and the bed body plane is parallel to the ground.
The advantage of technology of the present invention is, owing to utilize the bragg peak of charged particle that the target area is rotated irradiation, improved the dose distribution in target area and normal structure, in ideal conditions, can be heavy dose of, kill lesion tissue once.Owing to do not need suitable required diaphragm system or the sweeping magnet system of shape technology in the device of the present invention, and need the device of rotation to reduce, thereby the volume of treatment head reduces, and simple in structure, in light weight, cost reduces.
The present invention is described in further detail below in conjunction with drawings and Examples.
Fig. 1 is the sketch map that bragg peak is carried out vertical broadening;
Fig. 2 is the sketch map of existing proton therapeutic appts;
Fig. 3 is the sketch map of an embodiment of the illumination unit of 3-dimensional irradiation technology of the present invention;
Fig. 4 is the sketch map of the formed a kind of rotary irradiation of illumination unit shown in Figure 3 unit;
Fig. 5 is the sketch map of the formed another kind of rotary irradiation of illumination unit shown in Figure 3 unit;
Fig. 6 is the sketch map of another embodiment of the illumination unit of 3-dimensional irradiation technology of the present invention;
Fig. 7 is the sketch map of the formed a kind of rotary irradiation of illumination unit shown in Figure 6 unit;
Fig. 8 is the sketch map of the formed another kind of rotary irradiation of illumination unit shown in Figure 6 unit;
Fig. 9 a, Fig. 9 b～Figure 13 a, Figure 13 b are the schematic perspective views of five kinds of difform rotary irradiation units and corresponding illumination unit thereof;
Figure 14 is the sketch map to the exposure pathways of normal structure of 3-dimensional irradiation technology of the present invention;
Figure 15 is the sketch map of an embodiment of 3-dimensional irradiation device of the present invention;
Figure 16 is the generalized section of 3-dimensional irradiation device shown in Figure 15.
With reference to Fig. 3, Fig. 4, Fig. 5 as can be known, in the present embodiment, line is a proton beam, and illumination unit 3 is that a cross section is A
1B
1C
1D
1, A wherein
1B
1=x
1, B
1C
1=y
1, thickness is z
1Cube.x
1y
1Generally get 30 * 30mm
2～3 * 3mm
2
With reference to Fig. 6, Fig. 7, Fig. 8 as can be known, in the present embodiment, line is the proton beam that becomes the θ angle with the therapeutic bed plane, illumination unit 3 ' and be that a cross section is A
2B
2C
2D
2, A wherein
2B
2=x
2, A
2D
2=y
2, thickness is z
2Cube, and z
2=x
2Tg θ.x
2y
2Generally get 30 * 30mm
2～3 * 3mm
2Illumination unit 3 ' can be the bragg peak zone without broadening, then z
2Generally get 2.5mm; Also can be the bragg peak zone through broadening, then z
2Greater than 2.5mm.Gyroaxis O
2Vertical with the therapeutic bed plane, and cross D
2C
2', make therapeutic bed around O
2Rotation, then can obtain a cross-sectional area is y
2 2π, thickness are z
2The proximate cylinder irradiation unit 4 of sin θ '.If with O
2Move to O
2', make O
2' apart from limit D
2C
2' distance be R
2, apart from another limit A
2B
2' distance be (R
2+ y
2), make therapeutic bed around O
2' rotation, then can obtain a cross-sectional area is π (y
2 2+ 2y
2R
2), thickness is z
2The ring-type irradiation unit of sin θ.
By controlling the number of degrees that illumination unit turns over; Adopt difform illumination unit to be rotated; In rotary course, change the shape of illumination unit; Or can obtain various difform rotary irradiation unit by gyroaxis being selected in the means such as relative position different with illumination unit.Be five kinds of difform rotary irradiation units and corresponding illumination unit thereof shown in Fig. 9 a, Fig. 9 b～Figure 13 a, Figure 13 b, wherein, in preceding two kinds of situations, illumination unit is a cube, and in back three kinds of situations, illumination unit is a cylinder.We can go to the target area of the various complicated shapes of match with these basic rotary irradiation units.Can also turn off line in certain anglec of rotation, to protect responsive organ.
As shown in figure 14, charged particle beam enters human body, forms exposure pathways 6 at body surface, and 5 form required rotary irradiation unit in the target area.By adopting technology of the present invention, make line to the folk prescription of normal structure to, irradiation becomes the changing instantaneous irradiation of direction for a long time, thereby has improved line greatly in the intravital dose distribution of people.
3-dimensional irradiation technology of the present invention can realize with the turntable scheme of prior art.But the present invention also will provide the 3-dimensional irradiation device that a kind of and existing turntable scheme structure compared is simpler, weight is lighter, cost is lower.
With reference to Figure 15, Figure 16 as can be known, in the present embodiment, proton beam is drawn by proton synchrotron, and energy is adjustable at 250MeV～70MeV.Proton beam is drawn after beam-flow transmission line 7, bundle speckle amplify and to dwindle magnet system 8 and regulate bundle speckle sizes, and is provided with the safety of line switching device 9 when guaranteeing treatment, enters treatment 10 then, and the central shaft of line that enters treatment 10 is parallel to the ground.Treatment 10 comprises the colour killing of being made up of two 45 ° of deflection magnets 12 and quadrupole electromagnet 13 joint that looses, beam energy regulating system 14, the collimator system 16 of adjusting light spot shape and dose monitoring system 15 etc.Treatment 10 an employing dual-gripper mechanism 17 support, and can reduce amount of deflection like this.Make from the central shaft of treatment 10 line of drawing with to enter the central shaft for the treatment of a line of 10 vertical, and intersect at the O point.Treatment 10 can do around the O point and be no more than ± 45 ° simple harmonic motion, and can rest on unspecified angle.Because the device of treatment 10 inside significantly reduces than turntable of the prior art, the control ratio of the swing of treatment 10 is wanted simple to the control of turntable, required counterweight reduces, thereby has reduced volume, simplifies the structure, and has alleviated weight, has reduced cost.
Also can equip required diaphragm system of diffuse transmission type three-dimensional conformal irradiation or the required sweeping magnet system of equipment scan-type three-dimensional conformal irradiation in the treatment 10, to take into account conform irradiation to focus.
Therapeutic bed 11 comprises base 18, bed axle and bed body 21.Wherein, base comprises the guiding mechanism of directions X, can move along directions X; Bed axle comprises Z to elevating mechanism 20 and rotating mechanism 19, can be along Z to lifting, and rotate around the Z axle; Bed body 21 comprises the guiding mechanism of X and Y direction, can move along X and Y direction, and the bed body plane is parallel to the ground.Therapeutic bed 11 can also increase one or two degree of freedom, promptly around X to axle or Y rotation to axle, regulate when helping shining.
In when treatment, according to the shape of target area the target area is decomposed into one by one irradiation unit earlier, make treatment plan.According to treatment plan, under the control of electrical system, make treatment 10 swing and rest on certain angle then, adjustment of treatment bed 11 makes the bragg peak of charged particle drop on target area 5.Make therapeutic bed around the rotation of Z axle, rotating speed is slower, as is slower than 1 cycle per minute clock, like this, is equivalent to illumination unit around the rotation of Z axle, thereby forms rotary irradiation unit.Can turn off line by the line switching device in certain anglec of rotation, to protect responsive organ.As required, make treatment 10 swing and rest on another angle, the X that regulates base 18 makes therapeutic bed 11 pursuit movements to guiding mechanism and elevating mechanism 20, and making target area 5 remain at the O point is on the same swing circumference in the center of circle.Make therapeutic bed 11 around the rotation of Z axle, thereby form another rotary irradiation unit.Like this, just can realize 3-dimensional irradiation to whole target area.
Claims (7)
1, a kind of 3-dimensional irradiation technology with charged particle of Bragg peak character is characterized in that: the bragg peak zone without broadening of charged particle is chosen to be illumination unit (3), makes illumination unit around certain gyroaxis O
1Rotation, thus a rotary irradiation unit (4) formed; By treatment planning systems, remove the match target region shape with rotary irradiation unit (4).
2, a kind of 3-dimensional irradiation technology with charged particle of Bragg peak character is characterized in that: the bragg peak of charged particle is carried out broadening, the bragg peak zone of broadening is chosen to be illumination unit (3); Make illumination unit (3) around certain gyroaxis O simultaneously
1Rotation, rotating speed are slower than the speed of regulating the bragg peak degree of depth, thereby form a rotary irradiation unit (4); By treatment planning systems, remove the match target region shape with rotary irradiation unit (4).
3,3-dimensional irradiation technology according to claim 1 and 2 is characterized in that: at illumination unit (3) wraparound rotating shaft O
1In the process of rotation, change the shape of illumination unit (3).
4,3-dimensional irradiation technology according to claim 1 and 2 is characterized in that: the gyroaxis O of described illumination unit (3)
1Be parallel to the therapeutic bed plane.
5, the 3-dimensional irradiation technology of proton according to claim 1 and 2 is characterized in that: the gyroaxis O of described illumination unit (3 ')
2Perpendicular to the therapeutic bed plane.
6,3-dimensional irradiation technology according to claim 3 is characterized in that: the gyroaxis O of described illumination unit (3)
1Be parallel to the therapeutic bed plane.
7,3-dimensional irradiation technology according to claim 3 is characterized in that: the gyroaxis O of described illumination unit (3 ')
2Perpendicular to the therapeutic bed plane.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97101188A CN1052919C (en) | 1997-03-15 | 1997-03-15 | Three-dimensional irradiation tech. and equipment with charged particle having Bragg peak character |
| EP98104311A EP0864337A3 (en) | 1997-03-15 | 1998-03-10 | Three-dimensional irradiation technique with charged particles of Bragg peak properties and its device |
| JP6353498A JPH10263097A (en) | 1997-03-15 | 1998-03-13 | Method and device for three-dimensional irradiation using charged particle having bragg peak characteristic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97101188A CN1052919C (en) | 1997-03-15 | 1997-03-15 | Three-dimensional irradiation tech. and equipment with charged particle having Bragg peak character |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1161240A CN1161240A (en) | 1997-10-08 |
| CN1052919C true CN1052919C (en) | 2000-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97101188A Expired - Fee Related CN1052919C (en) | 1997-03-15 | 1997-03-15 | Three-dimensional irradiation tech. and equipment with charged particle having Bragg peak character |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10010523C2 (en) * | 2000-03-07 | 2002-08-14 | Schwerionenforsch Gmbh | Ion beam system for the irradiation of tumor tissue |
| US10912953B2 (en) | 2016-03-31 | 2021-02-09 | Varian Medical Systems Particle Therapy Gmbh | Adaptive pencil beam scanning |
| US9855445B2 (en) * | 2016-04-01 | 2018-01-02 | Varian Medical Systems, Inc. | Radiation therapy systems and methods for delivering doses to a target volume |
| CN107158583B (en) * | 2017-06-15 | 2018-07-31 | 合肥中科离子医学技术装备有限公司 | The conformal intensity modulated treatment head system of pencil beam and implementation method |
| CN109771849A (en) * | 2019-01-30 | 2019-05-21 | 张文山 | The non-equal centers of one kind rotate intensity ajustable radiation therapy apparatus |
| CN110787376B (en) * | 2019-11-29 | 2021-04-06 | 合肥中科离子医学技术装备有限公司 | Tumor patient positioning system based on proton imaging |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0561533A2 (en) * | 1992-03-19 | 1993-09-22 | Wisconsin Alumni Research Foundation | Method and apparatus for radiation therapy |
| CN1090515A (en) * | 1992-08-21 | 1994-08-10 | 诺摩斯公司 | Conformal radiation Therapeutic Method and device thereof |
| CN1107374A (en) * | 1994-02-26 | 1995-08-30 | 宋世鹏 | Rotary focus type radioactive therapeutic apparatus |
| US5668371A (en) * | 1995-06-06 | 1997-09-16 | Wisconsin Alumni Research Foundation | Method and apparatus for proton therapy |
-
1997
- 1997-03-15 CN CN97101188A patent/CN1052919C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0561533A2 (en) * | 1992-03-19 | 1993-09-22 | Wisconsin Alumni Research Foundation | Method and apparatus for radiation therapy |
| CN1090515A (en) * | 1992-08-21 | 1994-08-10 | 诺摩斯公司 | Conformal radiation Therapeutic Method and device thereof |
| CN1107374A (en) * | 1994-02-26 | 1995-08-30 | 宋世鹏 | Rotary focus type radioactive therapeutic apparatus |
| US5668371A (en) * | 1995-06-06 | 1997-09-16 | Wisconsin Alumni Research Foundation | Method and apparatus for proton therapy |
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|---|---|
| CN1161240A (en) | 1997-10-08 |
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