CN1076205C - 用于核磁共振成像的颗粒及其制备方法 - Google Patents
用于核磁共振成像的颗粒及其制备方法 Download PDFInfo
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- CN1076205C CN1076205C CN93116505A CN93116505A CN1076205C CN 1076205 C CN1076205 C CN 1076205C CN 93116505 A CN93116505 A CN 93116505A CN 93116505 A CN93116505 A CN 93116505A CN 1076205 C CN1076205 C CN 1076205C
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- surfactant
- phospholipid
- granule
- amphipathic compound
- core
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
- A61K49/1839—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
- Y10S977/838—Magnetic property of nanomaterial
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/905—Specially adapted for travel through blood circulatory system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
- Y10S977/953—Detector using nanostructure
- Y10S977/96—Of magnetic property
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2998—Coated including synthetic resin or polymer
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Abstract
Description
样品时间(分) | 1A*0:10 | 1B*100:0 | 1C*9:1 | 1D*7.5:2.5 | 1E*5:5 | 1F*2.5:7.5 | 1V1 | 1V2 |
10 | 80.5 | 12.3 | 52.7 | 72.5 | 76.1 | 79.9 | 1.2 | 1.5 |
30 | 72.7 | 1.4 | 22.2 | 63.8 | 72.4 | 72.8 | 0.8 | 0.7 |
60 | 59.3 | 1.0 | 10.3 | 53.4 | 63.5 | 66.1 | 0.8 | 0.7 |
90 | 54.0 | - | 5.7 | 48.7 | 58.3 | 57.3 | - | - |
120 | 41.4 | - | 4.0 | 41.3 | 52.2 | 48.0 | - | - |
AUC%分 | 7545 | 747 | 2386 | 6865 | 7889 | 7941 | 562 | 561 |
分 | 1D2(7.5:2.5) | 1E2(5:5) | 1F2(2.5:7.5) |
10 | 23.3 | 26.9 | 24.4 |
30 | 10.3 | 8.9 | 7.2 |
60 | 6.6 | 4.3 | 3.0 |
90 | 4.9 | 2.8 | 1.8 |
120 | 3.8 | 2.0 | 1.4 |
AUC%分 | 1509 | 1369 | 1211 |
样品时间(分) | 1G | 1H | 1J |
0 | 100 | 100 | 100 |
5 | 15.6 | 16.5 | 15.1 |
10 | 3.1 | 3.4 | — |
15 | 0.8 | 1.5 | 8.3 |
30 | 0.4 | 0.8 | 3.6 |
45 | — | — | 2.9 |
60 | — | — | — |
AUC%分 | 355 | 371 | 543 |
组 | 制 剂 | AUC(%分) |
a) | MAG/F108 | 924 |
MAG/BRIJ56 | 763 | |
b) | MAC/脂质体/F108 | 1039 |
脂质体/MAG(V) | 610 | |
脂质体/MAG(V)/F108 | 596 | |
c) | MAG/DAPC | 1053 |
MAG/DAPC/F108 | 875 | |
MAG/DPPC | 725 | |
MAG/DPPC/F108 | 860 | |
MAG/DMPC | 774 | |
MAG/DMPC/F108 | 1011 | |
d) | MAG/DPPG | 728 |
MAG/DPPG/F108 | 791 | |
MAG/DMPG | 600 | |
MAG/DMPG/F108 | 798 | |
e) | MAG/DPPA | 1428 |
MAG/DMPA | 1736 | |
f) | AMI 25(S)-葡聚糖 | 2866 |
组 | 制 剂 | AUC(%分) |
g) | MAG/DMPA/F108 | 9984 |
MAG/DPPA/F108 | 7813 | |
MAG/DPPA.2Na/F108 | 7767 | |
MAG/DPPA/F108+灭菌 | 7855 | |
MAG/DPPA/F108+冻干 | 7804 | |
MAG/DSPA/F108 | 7557 | |
MAG/SPA-3/F108 | 7639 | |
MAG/CETYL PHOSPHATE/F108 | 6657 | |
MAG/(DPPC/DPPA):(7.5/2.5)2/F108 | 6865 | |
MAG/(DPPC/DPPA):(5.0/5.0)3/F108 | 7889 | |
MAG/(DPPC/DPPA):(2.5/7.5)4/F108 | 7941 | |
MAG/(DPPA/CHOL):(1/1)/F108 | 8352 | |
MAG/DPPA/BRIJ56 | 6051 | |
MAG/DPPA/TWEEN80 | 4035 | |
MAG/DPPA/BRIJ58 | 3278 |
Fe3O4(mg/ml) | DPPA(mg/ml) | Synperonic F108(mg/ml) | AUC(%分) |
0.5 | 0.1 | 1.0 | >8000 |
0.5 | 0.3 | 3.0 | 7000 |
0.5 | 0.3 | 10.0 | >8000 |
0.5 | 3.5 | 3.5 | 6500 |
0.5 | 5.0 | 5.0 | 7500 |
0.5 | 10.0 | 10.0 | 8000 |
0.5 | 0.1 | 10.0 | ≈4000 |
0.5 | 1.0 | 10.0 | 6500 |
Claims (22)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92810618 | 1992-08-13 | ||
EP92810618.6 | 1992-08-13 | ||
EP9281618.6 | 1992-08-13 | ||
EP93810380 | 1993-05-25 | ||
EP93810380.1 | 1993-05-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1089470A CN1089470A (zh) | 1994-07-20 |
CN1076205C true CN1076205C (zh) | 2001-12-19 |
Family
ID=26132520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN93116505A Expired - Fee Related CN1076205C (zh) | 1992-08-13 | 1993-08-12 | 用于核磁共振成像的颗粒及其制备方法 |
Country Status (20)
Country | Link |
---|---|
US (3) | US5464696A (zh) |
EP (1) | EP0607401B1 (zh) |
JP (1) | JP2968588B2 (zh) |
KR (1) | KR100307773B1 (zh) |
CN (1) | CN1076205C (zh) |
AT (1) | ATE144714T1 (zh) |
AU (1) | AU660108B2 (zh) |
CA (1) | CA2119654C (zh) |
DE (1) | DE69305730T2 (zh) |
DK (1) | DK0607401T3 (zh) |
ES (1) | ES2094558T3 (zh) |
FI (1) | FI941677A0 (zh) |
GR (1) | GR3022288T3 (zh) |
HU (1) | HU221805B1 (zh) |
IL (1) | IL106493A (zh) |
IS (1) | IS1648B (zh) |
MX (1) | MX9304924A (zh) |
NO (1) | NO307244B1 (zh) |
NZ (1) | NZ254791A (zh) |
WO (1) | WO1994004197A1 (zh) |
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- 1993-07-27 IL IL10649393A patent/IL106493A/xx not_active IP Right Cessation
- 1993-07-27 IS IS4058A patent/IS1648B/is unknown
- 1993-07-30 AT AT93917714T patent/ATE144714T1/de not_active IP Right Cessation
- 1993-07-30 AU AU47054/93A patent/AU660108B2/en not_active Ceased
- 1993-07-30 EP EP93917714A patent/EP0607401B1/en not_active Expired - Lifetime
- 1993-07-30 NZ NZ254791A patent/NZ254791A/en unknown
- 1993-07-30 ES ES93917714T patent/ES2094558T3/es not_active Expired - Lifetime
- 1993-07-30 HU HU9401038A patent/HU221805B1/hu not_active IP Right Cessation
- 1993-07-30 DE DE69305730T patent/DE69305730T2/de not_active Expired - Lifetime
- 1993-07-30 DK DK93917714.3T patent/DK0607401T3/da active
- 1993-07-30 KR KR1019940701200A patent/KR100307773B1/ko not_active IP Right Cessation
- 1993-07-30 JP JP6505830A patent/JP2968588B2/ja not_active Expired - Fee Related
- 1993-07-30 WO PCT/EP1993/002046 patent/WO1994004197A1/en active IP Right Grant
- 1993-07-30 CA CA002119654A patent/CA2119654C/en not_active Expired - Fee Related
- 1993-08-12 CN CN93116505A patent/CN1076205C/zh not_active Expired - Fee Related
- 1993-08-13 MX MX9304924A patent/MX9304924A/es unknown
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1994
- 1994-04-12 FI FI941677A patent/FI941677A0/fi unknown
- 1994-04-12 NO NO941311A patent/NO307244B1/no not_active IP Right Cessation
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- 1995-04-13 US US08/421,329 patent/US5587199A/en not_active Expired - Lifetime
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- 1997-01-16 GR GR960403292T patent/GR3022288T3/el unknown
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CN100347562C (zh) * | 1998-01-05 | 2007-11-07 | Ge健康公司 | 磁共振研究方法 |
Also Published As
Publication number | Publication date |
---|---|
EP0607401A1 (en) | 1994-07-27 |
EP0607401B1 (en) | 1996-10-30 |
FI941677A (fi) | 1994-04-12 |
FI941677A0 (fi) | 1994-04-12 |
GR3022288T3 (en) | 1997-04-30 |
HU9401038D0 (en) | 1994-07-28 |
NZ254791A (en) | 1996-11-26 |
IL106493A (en) | 1997-02-18 |
DK0607401T3 (da) | 1996-11-25 |
JP2968588B2 (ja) | 1999-10-25 |
NO941311D0 (no) | 1994-04-12 |
AU660108B2 (en) | 1995-06-08 |
ES2094558T3 (es) | 1997-01-16 |
IL106493A0 (en) | 1993-11-15 |
JPH07503976A (ja) | 1995-04-27 |
US5464696A (en) | 1995-11-07 |
DE69305730T2 (de) | 1997-05-28 |
US5545395A (en) | 1996-08-13 |
US5587199A (en) | 1996-12-24 |
MX9304924A (es) | 1994-08-31 |
HUT75149A (en) | 1997-04-28 |
CA2119654C (en) | 2001-02-06 |
AU4705493A (en) | 1994-03-15 |
DE69305730D1 (de) | 1996-12-05 |
KR100307773B1 (ko) | 2001-12-28 |
HU221805B1 (hu) | 2003-01-28 |
IS1648B (is) | 1997-03-25 |
CA2119654A1 (en) | 1994-03-03 |
ATE144714T1 (de) | 1996-11-15 |
NO307244B1 (no) | 2000-03-06 |
CN1089470A (zh) | 1994-07-20 |
IS4058A (is) | 1994-02-14 |
WO1994004197A1 (en) | 1994-03-03 |
NO941311L (no) | 1994-04-12 |
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