CN1100046C - 喹唑啉衍生物 - Google Patents
喹唑啉衍生物 Download PDFInfo
- Publication number
- CN1100046C CN1100046C CN96193526A CN96193526A CN1100046C CN 1100046 C CN1100046 C CN 1100046C CN 96193526 A CN96193526 A CN 96193526A CN 96193526 A CN96193526 A CN 96193526A CN 1100046 C CN1100046 C CN 1100046C
- Authority
- CN
- China
- Prior art keywords
- quinazoline
- formula
- propoxy
- methoxyl group
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Abstract
Description
Claims (13)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9508538.7 | 1995-04-27 | ||
GBGB9508538.7A GB9508538D0 (en) | 1995-04-27 | 1995-04-27 | Quinazoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1182421A CN1182421A (zh) | 1998-05-20 |
CN1100046C true CN1100046C (zh) | 2003-01-29 |
Family
ID=10773597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96193526A Expired - Lifetime CN1100046C (zh) | 1995-04-27 | 1996-04-23 | 喹唑啉衍生物 |
Country Status (39)
Country | Link |
---|---|
US (1) | US5770599A (zh) |
EP (1) | EP0823900B1 (zh) |
JP (1) | JP3040486B2 (zh) |
KR (1) | KR100296656B1 (zh) |
CN (1) | CN1100046C (zh) |
AR (1) | AR003944A1 (zh) |
AT (1) | ATE198329T1 (zh) |
AU (1) | AU699163B2 (zh) |
BG (1) | BG62730B1 (zh) |
BR (1) | BRPI9608082B8 (zh) |
CA (1) | CA2215732C (zh) |
CZ (1) | CZ288489B6 (zh) |
DE (2) | DE69611361T2 (zh) |
DK (1) | DK0823900T3 (zh) |
EE (1) | EE03482B1 (zh) |
EG (1) | EG24134A (zh) |
ES (1) | ES2153098T3 (zh) |
FR (1) | FR09C0065I2 (zh) |
GB (1) | GB9508538D0 (zh) |
GR (1) | GR3035211T3 (zh) |
HK (1) | HK1005371A1 (zh) |
HR (1) | HRP960204B1 (zh) |
HU (1) | HU223313B1 (zh) |
IL (1) | IL118045A (zh) |
LU (1) | LU91631I2 (zh) |
MY (1) | MY114425A (zh) |
NL (1) | NL300429I1 (zh) |
NO (2) | NO309472B1 (zh) |
NZ (1) | NZ305444A (zh) |
PL (1) | PL189182B1 (zh) |
PT (1) | PT823900E (zh) |
RO (1) | RO117849B1 (zh) |
RU (1) | RU2153495C2 (zh) |
SI (1) | SI0823900T1 (zh) |
SK (1) | SK282236B6 (zh) |
TW (1) | TW436486B (zh) |
UA (1) | UA52602C2 (zh) |
WO (1) | WO1996033980A1 (zh) |
ZA (1) | ZA963358B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007082434A1 (fr) * | 2006-01-20 | 2007-07-26 | Shanghai Allist Pharmaceutical., Inc. | Dérivés de quinazoline, leurs procédés de fabrication et utilisations |
CN112321814A (zh) * | 2020-12-30 | 2021-02-05 | 广州初曲科技有限公司 | 一种吉非替尼艾地苯醌轭合物的制备及用途 |
Families Citing this family (696)
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GB9508535D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivative |
GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
GB9508565D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
WO1996033977A1 (en) * | 1995-04-27 | 1996-10-31 | Zeneca Limited | Quinazoline derivatives |
US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
EP0880508B1 (en) | 1996-02-13 | 2003-04-16 | AstraZeneca AB | Quinazoline derivatives as vegf inhibitors |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
GB9603097D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline compounds |
WO1997032856A1 (en) | 1996-03-05 | 1997-09-12 | Zeneca Limited | 4-anilinoquinazoline derivatives |
CA2249446C (en) | 1996-04-12 | 2008-06-17 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
GB9607729D0 (en) * | 1996-04-13 | 1996-06-19 | Zeneca Ltd | Quinazoline derivatives |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
CN1147317C (zh) * | 1997-08-15 | 2004-04-28 | 赛福伦公司 | 含酪氨酸激酶抑制剂和化学阉割剂的组合物及其用于制药的用途 |
WO1999010349A1 (en) | 1997-08-22 | 1999-03-04 | Zeneca Limited | Oxindolylquinazoline derivatives as angiogenesis inhibitors |
US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
US6864227B1 (en) * | 1998-04-13 | 2005-03-08 | California Institute Of Technology | Artery-and vein-specific proteins and uses therefor |
US6887674B1 (en) | 1998-04-13 | 2005-05-03 | California Institute Of Technology | Artery- and vein-specific proteins and uses therefor |
ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
US7354894B2 (en) * | 1998-08-18 | 2008-04-08 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
SK287805B6 (sk) | 1998-08-18 | 2011-10-04 | The Regents Of The University Of California | Použitie antagonistu receptora epidermálneho rastového faktora (EGF-R) na výrobu lieku na liečenie nadmerného vylučovania hlienu v dýchacích cestách |
JP2002523403A (ja) | 1998-08-21 | 2002-07-30 | パーカー ヒューズ インスティテュート | キナゾリン誘導体 |
PL218769B1 (pl) | 1998-09-29 | 2015-01-30 | Wyeth Corp | Podstawione 3-cyjanochinoliny lub ich farmaceutycznie dopuszczalne sole jako inhibitory białkowych kinaz tyrozynowych |
US6288082B1 (en) | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
AU766077C (en) * | 1998-11-20 | 2004-10-07 | Genentech Inc. | Uses for Eph receptor antagonists and agonists to treat vascular disorders |
US6972288B1 (en) | 1999-02-27 | 2005-12-06 | Boehringer Ingelheim Pharma Kg | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases |
DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
BR0010524A (pt) * | 1999-05-14 | 2002-05-28 | Imclone Systems Inc | Tratamento de tumores humanos refratários com antagonistas de receptor de fator de crescimento epidérmico |
UA71976C2 (en) | 1999-06-21 | 2005-01-17 | Boehringer Ingelheim Pharma | Bicyclic heterocycles and a medicament based thereon |
US6432979B1 (en) | 1999-08-12 | 2002-08-13 | American Cyanamid Company | Method of treating or inhibiting colonic polyps and colorectal cancer |
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US20020002169A1 (en) | 1999-12-08 | 2002-01-03 | Griffin John H. | Protein kinase inhibitors |
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GB0008368D0 (en) * | 2000-04-06 | 2000-05-24 | Astrazeneca Ab | Combination product |
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DE10042058A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US6656946B2 (en) | 2000-08-26 | 2003-12-02 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
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Cited By (5)
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WO2007082434A1 (fr) * | 2006-01-20 | 2007-07-26 | Shanghai Allist Pharmaceutical., Inc. | Dérivés de quinazoline, leurs procédés de fabrication et utilisations |
US8044063B2 (en) | 2006-01-20 | 2011-10-25 | Shanghai Allist Pharmaceuticals, Inc. | Quinazoline derivatives useful as anti-tumor medicament |
US8309563B2 (en) | 2006-01-20 | 2012-11-13 | Shanghai Allist Pharmaceuticals, Inc. | Quinazoline derivatives useful as anti-tumor medicament |
CN112321814A (zh) * | 2020-12-30 | 2021-02-05 | 广州初曲科技有限公司 | 一种吉非替尼艾地苯醌轭合物的制备及用途 |
CN112321814B (zh) * | 2020-12-30 | 2021-03-23 | 广州初曲科技有限公司 | 一种吉非替尼艾地苯醌轭合物的制备及用途 |
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