CN1132845C - 获得具有正确键合的胱氨酸键的胰岛素前体的改进的方法 - Google Patents
获得具有正确键合的胱氨酸键的胰岛素前体的改进的方法 Download PDFInfo
- Publication number
- CN1132845C CN1132845C CN98117909A CN98117909A CN1132845C CN 1132845 C CN1132845 C CN 1132845C CN 98117909 A CN98117909 A CN 98117909A CN 98117909 A CN98117909 A CN 98117909A CN 1132845 C CN1132845 C CN 1132845C
- Authority
- CN
- China
- Prior art keywords
- amino
- insulin
- acid residue
- peptide
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Description
Claims (16)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19735711.3 | 1997-08-18 | ||
DE19735711A DE19735711C2 (de) | 1997-08-18 | 1997-08-18 | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN031523307A Division CN1483831B (zh) | 1997-08-18 | 1998-08-17 | 获得具有正确键合的胱氨酸键的胰岛素或胰岛素衍生物的方法 |
CN2006101000625A Division CN101186940B (zh) | 1997-08-18 | 1998-08-17 | 获得具有正确键合的胱氨酸键的胰岛素或胰岛素衍生物的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1209437A CN1209437A (zh) | 1999-03-03 |
CN1132845C true CN1132845C (zh) | 2003-12-31 |
Family
ID=7839275
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN98117909A Expired - Lifetime CN1132845C (zh) | 1997-08-18 | 1998-08-17 | 获得具有正确键合的胱氨酸键的胰岛素前体的改进的方法 |
CN031523307A Expired - Lifetime CN1483831B (zh) | 1997-08-18 | 1998-08-17 | 获得具有正确键合的胱氨酸键的胰岛素或胰岛素衍生物的方法 |
CN2006101000625A Expired - Lifetime CN101186940B (zh) | 1997-08-18 | 1998-08-17 | 获得具有正确键合的胱氨酸键的胰岛素或胰岛素衍生物的方法 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN031523307A Expired - Lifetime CN1483831B (zh) | 1997-08-18 | 1998-08-17 | 获得具有正确键合的胱氨酸键的胰岛素或胰岛素衍生物的方法 |
CN2006101000625A Expired - Lifetime CN101186940B (zh) | 1997-08-18 | 1998-08-17 | 获得具有正确键合的胱氨酸键的胰岛素或胰岛素衍生物的方法 |
Country Status (21)
Country | Link |
---|---|
US (3) | US5986048A (zh) |
EP (2) | EP0980874B1 (zh) |
JP (1) | JP4291900B2 (zh) |
KR (2) | KR100537842B1 (zh) |
CN (3) | CN1132845C (zh) |
AR (1) | AR016821A1 (zh) |
AT (2) | ATE217636T1 (zh) |
AU (1) | AU744824B2 (zh) |
BR (2) | BR9803755A (zh) |
CA (1) | CA2245151C (zh) |
CZ (1) | CZ295679B6 (zh) |
DE (3) | DE19735711C2 (zh) |
DK (2) | DK0980874T3 (zh) |
ES (2) | ES2177178T3 (zh) |
HK (3) | HK1018464A1 (zh) |
HU (2) | HU228203B1 (zh) |
ID (1) | ID20717A (zh) |
PL (1) | PL191901B1 (zh) |
PT (2) | PT906918E (zh) |
RU (2) | RU2205836C2 (zh) |
TR (1) | TR199801587A3 (zh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19735711C2 (de) | 1997-08-18 | 2001-04-26 | Aventis Pharma Gmbh | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
DE19930676B4 (de) * | 1999-07-02 | 2006-01-19 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln |
JP2003530316A (ja) | 1999-12-22 | 2003-10-14 | ノボ ノルディスク アクティーゼルスカブ | スクランブルした一本鎖ポリペプチドの抽出的再生法 |
AU2001280436A1 (en) * | 2000-07-12 | 2002-01-21 | Eli Lilly And Company | Process to increase protein stability |
DE10235168A1 (de) * | 2002-08-01 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Verfahren zur Reinigung von Preproinsulin |
DE102004015965A1 (de) * | 2004-04-01 | 2005-10-20 | Aventis Pharma Gmbh | Verfahren zur Gewinnung von Insulinen durch verbesserte Luftbegasung der Faltung |
EP2336164A1 (en) | 2005-12-22 | 2011-06-22 | Genentech, Inc. | Recombinant production of heparin binding proteins |
RU2439076C2 (ru) | 2006-07-14 | 2012-01-10 | Дженентек, Инк. | Способ выделения повторно свернутого рекомбинантного белка из культуры прокариотических клеток (варианты) |
EP2544008A1 (en) * | 2007-07-03 | 2013-01-09 | Amgen Inc. | Measurement of protein using inclusion body dry weight |
RU2451750C2 (ru) * | 2007-09-24 | 2012-05-27 | Общество С Ограниченной Ответственностью "Герофарм" | Способ получения рекомбинантного с-пептида проинсулина человека |
PL2229407T3 (pl) | 2008-01-09 | 2017-06-30 | Sanofi-Aventis Deutschland Gmbh | Nowe pochodne insuliny o ekstremalnie spowolnionym profilu czasu działania |
WO2009133529A2 (en) * | 2008-04-30 | 2009-11-05 | Wockhardt Research Centre | Processes for refolding of insulin |
WO2010043566A2 (de) | 2008-10-17 | 2010-04-22 | Sanofi-Aventis Deutschland Gmbh | Kombination von einem insulin und einem glp-1-agonisten |
AU2010317994B2 (en) | 2009-11-13 | 2014-03-06 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
PL2498802T3 (pl) | 2009-11-13 | 2015-06-30 | Sanofi Aventis Deutschland | Kompozycja farmaceutyczna zawierająca agonistę GLP-1, insulinę i metioninę |
AU2010360116B2 (en) | 2010-08-30 | 2014-06-26 | Sanofi-Aventis Deutschland Gmbh | Use of AVE0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
US20180282405A1 (en) * | 2012-08-05 | 2018-10-04 | Absci, Llc | Cytoplasmic expression system |
US10421795B2 (en) | 2012-12-17 | 2019-09-24 | Merck Sharp & Dohme Corp. | Process for purifying insulin and analogues thereof |
SG11201506095TA (en) * | 2013-02-26 | 2015-09-29 | Hanmi Pharm Ind Co Ltd | Novel insulin analog and use thereof |
CN103694339B (zh) * | 2013-12-04 | 2017-10-13 | 珠海联邦制药股份有限公司 | 一种甘精胰岛素前体的复性方法 |
EP3116531B1 (en) | 2014-03-14 | 2021-10-20 | Merck Sharp & Dohme Corp. | Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature |
HUE062573T2 (hu) | 2014-12-12 | 2023-11-28 | Sanofi Aventis Deutschland | Glargin inzulin/lixiszenatid rögzített arányú készítmény |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
CN104911203A (zh) * | 2015-06-30 | 2015-09-16 | 成都易胜科生物科技有限公司 | 一种重组人胰岛素的工业制备方法 |
EP3344651B1 (en) | 2015-09-02 | 2022-03-02 | Merck Sharp & Dohme Corp. | A process for obtaining insulin with correctly formed disulfide bonds |
US10689430B2 (en) | 2016-05-25 | 2020-06-23 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
WO2018018613A1 (zh) | 2016-07-29 | 2018-02-01 | 广东东阳光药业有限公司 | 一种提高抗体纯度的细胞培养基和培养方法 |
CN113773400B (zh) * | 2020-06-09 | 2023-08-18 | 宁波鲲鹏生物科技有限公司 | 一种门冬胰岛素衍生物及其应用 |
CN113773391B (zh) * | 2020-06-09 | 2023-10-20 | 宁波鲲鹏生物科技有限公司 | 一种门冬胰岛素的制备方法 |
CN113773396A (zh) * | 2020-06-10 | 2021-12-10 | 宁波鲲鹏生物科技有限公司 | 一种地特胰岛素衍生物及其应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ199391A (en) * | 1981-01-02 | 1985-12-13 | Genentech Inc | Chimeric polypeptides comprising a proinsulin sequence,and preparation by recombinant dna technique;production of human insulin |
DE3501641A1 (de) * | 1985-01-19 | 1986-07-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen |
IL95495A (en) * | 1989-08-29 | 1996-10-16 | Hoechst Ag | Fusion proteins their preparation and use |
DE59305396D1 (de) * | 1992-12-02 | 1997-03-20 | Hoechst Ag | Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken |
DE4405179A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
HU223718B1 (hu) * | 1994-12-29 | 2004-12-28 | Savient Pharmaceuticals, Inc. | Eljárás humán inzulin előállítására, proinzulin-tartalmú hibridpolipeptid expressziójából kiindulva |
DE19735711C2 (de) * | 1997-08-18 | 2001-04-26 | Aventis Pharma Gmbh | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
-
1997
- 1997-08-18 DE DE19735711A patent/DE19735711C2/de not_active Expired - Lifetime
-
1998
- 1998-08-11 EP EP99115386A patent/EP0980874B1/de not_active Expired - Lifetime
- 1998-08-11 PT PT98115048T patent/PT906918E/pt unknown
- 1998-08-11 EP EP98115048A patent/EP0906918B1/de not_active Expired - Lifetime
- 1998-08-11 DE DE59803985T patent/DE59803985D1/de not_active Expired - Lifetime
- 1998-08-11 AT AT98115048T patent/ATE217636T1/de active
- 1998-08-11 ES ES99115386T patent/ES2177178T3/es not_active Expired - Lifetime
- 1998-08-11 DE DE59804121T patent/DE59804121D1/de not_active Expired - Lifetime
- 1998-08-11 DK DK99115386T patent/DK0980874T3/da active
- 1998-08-11 PT PT99115386T patent/PT980874E/pt unknown
- 1998-08-11 AT AT99115386T patent/ATE217012T1/de active
- 1998-08-11 DK DK98115048T patent/DK0906918T3/da active
- 1998-08-11 ES ES98115048T patent/ES2176870T3/es not_active Expired - Lifetime
- 1998-08-14 ID IDP981136A patent/ID20717A/id unknown
- 1998-08-14 AR ARP980104052A patent/AR016821A1/es active IP Right Grant
- 1998-08-14 CA CA002245151A patent/CA2245151C/en not_active Expired - Lifetime
- 1998-08-17 AU AU80763/98A patent/AU744824B2/en not_active Expired
- 1998-08-17 TR TR1998/01587A patent/TR199801587A3/tr unknown
- 1998-08-17 BR BR9803755-2A patent/BR9803755A/pt not_active Application Discontinuation
- 1998-08-17 CN CN98117909A patent/CN1132845C/zh not_active Expired - Lifetime
- 1998-08-17 RU RU98116259/04A patent/RU2205836C2/ru active
- 1998-08-17 BR BRPI9816233A patent/BRPI9816233B8/pt not_active IP Right Cessation
- 1998-08-17 CZ CZ19982598A patent/CZ295679B6/cs not_active IP Right Cessation
- 1998-08-17 HU HU0600287A patent/HU228203B1/hu unknown
- 1998-08-17 HU HU9801886A patent/HU228161B1/hu unknown
- 1998-08-17 US US09/134,836 patent/US5986048A/en not_active Expired - Lifetime
- 1998-08-17 CN CN031523307A patent/CN1483831B/zh not_active Expired - Lifetime
- 1998-08-17 JP JP23036898A patent/JP4291900B2/ja not_active Expired - Lifetime
- 1998-08-17 CN CN2006101000625A patent/CN101186940B/zh not_active Expired - Lifetime
- 1998-08-18 PL PL328108A patent/PL191901B1/pl unknown
- 1998-08-18 KR KR1019980033384A patent/KR100537842B1/ko not_active IP Right Cessation
-
1999
- 1999-08-06 HK HK99103399A patent/HK1018464A1/xx not_active IP Right Cessation
- 1999-08-31 US US09/386,303 patent/US6380355B1/en not_active Expired - Lifetime
-
2001
- 2001-09-07 US US09/947,563 patent/US6727346B2/en not_active Expired - Lifetime
-
2002
- 2002-10-07 RU RU2002126598/15A patent/RU2302882C2/ru active
-
2004
- 2004-07-06 HK HK04104835.7A patent/HK1061870A1/xx not_active IP Right Cessation
-
2005
- 2005-05-27 KR KR1020050044974A patent/KR100574580B1/ko not_active IP Right Cessation
-
2008
- 2008-07-18 HK HK08107963.0A patent/HK1119449A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Applicant after: Awentis Medicines Deutschland GmbH Applicant before: German Beh Chester Marie Applicant before: Searl Oro Co. Ltd. |
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COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: HOECHST MARION GERMANY; MOSHIER LTD. TO: AVENTIS PHARMACY (GERMANY)INTERNATIONAL CO., LTD. |
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Owner name: SANOFI- AVENTIS GERMAN CO., LTD. Free format text: FORMER NAME OR ADDRESS: AVENTIS PHARMACY (GERMANY)INTERNATIONAL CO., LTD. |
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Address after: Frankfurt, Federal Republic of Germany Patentee after: Aventis Pharma GmbH Address before: Frankfurt, Federal Republic of Germany Patentee before: Awentis Medicines Deutschland GmbH |
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Granted publication date: 20031231 |