CN1173361A - Medicines contg. red coloring agent for food for bringing down blood pressure and reducing blood sugar and its prepn. method - Google Patents
Medicines contg. red coloring agent for food for bringing down blood pressure and reducing blood sugar and its prepn. method Download PDFInfo
- Publication number
- CN1173361A CN1173361A CN 97112548 CN97112548A CN1173361A CN 1173361 A CN1173361 A CN 1173361A CN 97112548 CN97112548 CN 97112548 CN 97112548 A CN97112548 A CN 97112548A CN 1173361 A CN1173361 A CN 1173361A
- Authority
- CN
- China
- Prior art keywords
- monas cuspurpureus
- cuspurpureus went
- strain
- powder
- blood sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
A biologic medicine for reducing blood pressure, blood fat and blood sugar is prepared from malt extract, maltase syrup, monascus purpureus, long-grained or round-grained nonglutinous rice, and soybean cake power or soybean powder through microbe fermentation, and features simple preparing process, reliable curative effect and no by-effect.
Description
The present invention relates to a kind of hypertension and hyperlipemia blood sugar lowering Monas cuspurpureus Went medicine and preparation method thereof.Be the hypoglycemic biological medicine of a kind of hypertension and hyperlipemia that raw material adopts microbial fermentation to make with beerwort, maltose slurry, Monascus anka Nakazawa et sato and Semen Oryzae or Semen oryzae sativae, soybean cake powder or analysis for soybean powder etc. specifically, the invention still further relates to the preparation method of this medicine.
At present, China's urban population has surpassed cancer because of cardiovascular and cerebrovascular disease causes dead number, occupies first of the various causes of the death, and this has caused China medical science and technology worker's great attention, for many years, they have just carried out many-sided researchs such as Monas cuspurpureus Went and preparation method thereof, treatment mechanism, and the medicine that has can play the effect of blood fat reducing, but the effect of its blood fat reducing is very little, it is exactly external similar fat-reducing medicament, not only cost an arm and a leg, also have side effect, only have indivedual large hospitals that clinic trial is arranged.
The object of the present invention is to provide a kind of significant hypertension and hyperlipemia blood sugar lowering that has, improve high blood coagulation state, mediation microcirculation, enhancing human body immunity function, a kind of Monas cuspurpureus Went medicine that has no side effect and preparation method thereof.
The object of the present invention is achieved like this:
It mainly by Monas cuspurpureus Went strain, wheat tooth juice, maltose slurry, magnesium sulfate powder, Semen Oryzae or Semen oryzae sativae, soybean cake powder or analysis for soybean powder, etc., form through strain cultivation, solid fermentation, mixing, high temperature sterilize, oven dry, pulverizing, packing, it is characterized in that raw material is:
Wheat tooth juice 500-900 milliliter maltose slurry 100-500 milliliter
Magnesium sulfate powder 0.001-0.02 kilogram Semen Oryzae or Semen oryzae sativae 100-2000 kilogram
Soybean cake powder or analysis for soybean powder 5-600 kilogram Monas cuspurpureus Went strain 1-5 prop up the test tube slant culture.
Its feature also is to prepare the raw material that Monas cuspurpureus Went strain 5-30 props up the test tube slant culture:
100 milliliters in wheat tooth juice
Agar 0.8-3 gram
Naoh concentration is 10%
The preparation method of hypertension and hyperlipemia blood sugar lowering Monas cuspurpureus Went medicine of the present invention is:
1. Monas cuspurpureus Went strain preparation:
With 100 milliliters in 3-5 ° of Be wheat tooth juice, agar 0.8-3 gram is mixed well with 10% sodium hydroxide, and the control pH value is between 5.0-8.0, and packing 5-30 props up test tube then, and sterilization is 30 minutes under 121 ℃ condition, bevel,
5-30 is propped up the test tube slant streak inoculation, under 20-40 ℃ condition, cultivated 3-5 days, the Monas cuspurpureus Went strain, under 2-10 ℃ condition, preserve standby,
2. strain cultivation, culture medium:
1-10 ° of Be (mother-in-law U.S. degree) wheat tooth juice 500-900 milliliter, 1-10 ° of Be maltose slurry 100-500 milliliter adds magnesium sulfate powder 1 gram-20 grams, after inoculation Monascus anka Nakazawa et sato 1-5 props up slant culture, uses shaking table or air compressor machine, feeds pressure and be 0.2-0.6 kilogram/(cm)
2Filtrated air, cultivated 5-10 days,
3. solid fermentation: get 100-2000 kilogram Semen Oryzae or Semen oryzae sativae and soaked at ambient temperature 2-5 hour with tap water, drench and do that soybean cake powder is sneaked into by the 5-30% that does Mi Chongliang in the back or analysis for soybean powder stirs, at 110-130 ℃ high temperature sterilize, sterilization time is 0.5-4 hour,
4. inoculate the liquid spawn mixing by the 5-50% that does Mi Chongliang,
5. cultivation temperature 20-35 ℃,
6. incubation time is 15-60 days,
7. the afterproduct that will ferment is sterilized in autoclave sterilizer at 110-130 ℃, and sterilization time is 0.5-3 hour, with dehydrator or drying room oven dry, makes water content reach 1-10%, will dry thing and pulverize, and smashing fineness is the 80-120 order,
8. the fine powder after pulverizing is made tablet with tablet machine, or is processed into powder, or uses capsule filling machine to make capsule, and every tablet is the 0.1-0.5 gram, and every capsules is the 0.2-0.5 gram.
The wheat tooth juice that its feature also is to be used for the Monas cuspurpureus Went strain preparation is 3-5 ° of Be wheat tooth juice
The wheat tooth juice that its feature also is to be used for strain cultivation, culture medium is 1-10 ° of Be wheat tooth juice.
The maltose slurry that its feature also is to be used for strain cultivation, culture medium is a 1-10 ° of Be maltose slurry.
Clinical drug of the present invention uses the result to show that compared with prior art its cost is low, and production technology is simple, and treatment is convenient, and curative effect is reliable, has no side effect, and clinical scope is wide, and short treating period is a kind of ideal hypertension and hyperlipemia blood sugar lowering Monas cuspurpureus Went medicine.
Below in conjunction with embodiment the present invention is described, the scheme of embodiment described here, do not limit the present invention, one of skill in the art can make improvements and change according to spirit of the present invention, described these improvement and variation all should be considered as within the scope of the invention, and scope and spirit of the present invention are limited by claim.
Embodiment
Choose raw material by following proportioning:
100 milliliters in 500 milliliters of maltose slurries of wheat tooth juice
0.001 kilogram of Semen Oryzae of magnesium sulfate powder or Semen oryzae sativae double centner
1 slant culture of 5 kilograms of Monas cuspurpureus Went strains of soybean cake powder or analysis for soybean powder
1. strain cultivation, culture medium:
After wheat tooth juice and maltose slurry mixed, add the magnesium sulfate powder, behind the inoculation Monas cuspurpureus Went strain, use air compressor machine, feed pressure and be 0.3 kilogram/(cm)
2Filtrated air, cultivated 6 days, liquid spawn
3. solid fermentation: get Semen Oryzae and soaked at ambient temperature 2.5 hours with tap water, drench and sneak into analysis for soybean powder after doing and stir, at 120 ℃ of high temperature sterilizes, sterilization time is about 1 hour,
4. inoculate 5 kilograms of liquid spawn mixings,
5. cultivation temperature is about 25 ℃,
6. incubation time is 25 days,
7. will ferment and sterilize in the autoclave sterilizer of afterproduct about 120 ℃, sterilization time is about 1 hour, Tumblies Dry, and water content is reached about 5%, will dry thing and pulverize, and smashing fineness is 100 orders,
8. the fine powder after pulverizing is made tablet with tablet machine, and every tablet is 0.3 gram.Promptly get hypertension and hyperlipemia blood sugar lowering Monas cuspurpureus Went medicinal tablet of the present invention.
Claims (6)
1, a kind of hypertension and hyperlipemia blood sugar lowering Monas cuspurpureus Went medicine, it is mainly by Monas cuspurpureus Went strain, wheat tooth juice, maltose slurry, magnesium sulfate powder, Semen Oryzae or Semen oryzae sativae, soybean cake powder or analysis for soybean powder etc., form through strain cultivation, solid fermentation, mixing, high temperature sterilize, oven dry, pulverizing, packing, it is characterized in that raw material is:
Wheat tooth juice 500-900 milliliter maltose slurry 100-500 milliliter
Magnesium sulfate powder 0.001-0.02 kilogram Semen Oryzae or Semen oryzae sativae 100-2000 kilogram
Soybean cake powder or analysis for soybean powder 5-600 kilogram Monas cuspurpureus Went strain 1-5 prop up the test tube slant culture.
2, hypertension and hyperlipemia blood sugar lowering Monas cuspurpureus Went medicine according to claim 1 is characterized in that preparing the raw material that Monas cuspurpureus Went strain 5-30 props up the test tube slant culture and is:
100 milliliters in wheat tooth juice
Agar 0.8-3 gram
Naoh concentration is 10%.
3, the preparation method of hypertension and hyperlipemia blood sugar lowering Monas cuspurpureus Went medicine according to claim 1 is characterized in that:
1. Monas cuspurpureus Went strain preparation:
With 100 milliliters in 3-5 ° of Be wheat tooth juice, agar 0.8-3 gram is mixed well with the sodium hydroxide of 10% concentration, and the control pH value is between 5.0-8.0, and packing 5-30 props up test tube then, and sterilization is 30 minutes under 121 ℃ condition, bevel,
5-30 is propped up the test tube slant streak inoculation, under 20-40 ℃ condition, cultivated 3-5 days, the Monas cuspurpureus Went strain, under 2-10 ℃ condition, preserve standby,
2. strain cultivation, culture medium:
1-10 ° of Be (mother-in-law U.S. degree) wheat tooth juice 500-900 milliliter, 1-10 ° of Be maltose slurry 100-500 milliliter adds magnesium sulfate powder 1 gram-20 grams, after inoculation Monascus anka Nakazawa et sato 1-5 props up slant culture, uses shaking table or air compressor machine, feeds pressure and be 0.2-0.6 kilogram/(cm)
2Filtrated air, cultivated 5-10 days,
3. solid fermentation: get 100-2000 kilogram Semen Oryzae or Semen oryzae sativae and soaked at ambient temperature 2-5 hour with tap water, drench and do that soybean cake powder is sneaked into by the 5-30% that does Mi Chongliang in the back or analysis for soybean powder stirs, at 110-130 ℃ high temperature sterilize, sterilization time is 0.5-4 hour,
4. inoculate the liquid spawn mixing by the 5-50% that does Mi Chongliang,
5. cultivation temperature 20-35 ℃,
6. incubation time is 15-60 days,
7. the afterproduct that will ferment is sterilized in autoclave sterilizer at 110-130 ℃, and sterilization time is 0.5-3 hour, with dehydrator or drying room oven dry, makes water content reach 1-10%, will dry thing and pulverize, and smashing fineness is the 80-120 order,
8. the fine powder after pulverizing is made tablet with tablet machine, or is processed into powder, or uses capsule filling machine to make capsule, and every tablet is the 0.1-0.5 gram, and every capsules is the 0.2-0.5 gram.
4, according to the preparation method of the described hypertension and hyperlipemia blood sugar lowering of claim 1-3 Monas cuspurpureus Went medicine, the wheat tooth juice that its feature also is to be used for the Monas cuspurpureus Went strain preparation is 3-5 ° of Be wheat tooth juice
5, according to the preparation method of the described hypertension and hyperlipemia blood sugar lowering of claim 1-3 Monas cuspurpureus Went medicine, the wheat tooth juice that its feature also is to be used for strain cultivation, culture medium is 1-10 ° of Be wheat tooth juice.
6, according to the preparation method of the described hypertension and hyperlipemia blood sugar lowering of claim 1-3 Monas cuspurpureus Went medicine, the maltose slurry that its feature also is to be used for strain cultivation, culture medium is a 1-10 ° of Be maltose slurry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97112548 CN1173361A (en) | 1997-07-22 | 1997-07-22 | Medicines contg. red coloring agent for food for bringing down blood pressure and reducing blood sugar and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97112548 CN1173361A (en) | 1997-07-22 | 1997-07-22 | Medicines contg. red coloring agent for food for bringing down blood pressure and reducing blood sugar and its prepn. method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1173361A true CN1173361A (en) | 1998-02-18 |
Family
ID=5172341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97112548 Pending CN1173361A (en) | 1997-07-22 | 1997-07-22 | Medicines contg. red coloring agent for food for bringing down blood pressure and reducing blood sugar and its prepn. method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1173361A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999023996A2 (en) * | 1997-11-06 | 1999-05-20 | Peking University | Compositions containing red rice fermentation products, frementation processes and monascus strains therefor |
| CN1095376C (en) * | 1999-08-20 | 2002-12-04 | 焦柏忠 | Julongyin Beverage and making method thereof |
| US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
-
1997
- 1997-07-22 CN CN 97112548 patent/CN1173361A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6632428B1 (en) | 1996-09-30 | 2003-10-14 | Peking University | Methods and compositions employing red rice fermentation products |
| US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
| WO1999023996A2 (en) * | 1997-11-06 | 1999-05-20 | Peking University | Compositions containing red rice fermentation products, frementation processes and monascus strains therefor |
| WO1999023996A3 (en) * | 1997-11-06 | 1999-08-19 | Univ Beijing | Compositions containing red rice fermentation products, frementation processes and monascus strains therefor |
| CN1095376C (en) * | 1999-08-20 | 2002-12-04 | 焦柏忠 | Julongyin Beverage and making method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101760478B (en) | Preparation method of radix puerariae red yeast rice | |
| CN105559084B (en) | Tree peony ferment and preparation method and application | |
| CN106072491B (en) | A kind of fructus arctii base Ganoderma lucidum mycelium powder and preparation method thereof | |
| CN101401826A (en) | Method for solid-state fermentation processing process for traditional Chinese medicine | |
| CN113080324A (en) | Pig feed additive and production method thereof | |
| CN102296098A (en) | Method for producing high-purity coriolus versicolor polysaccharopeptide by using modern fermentation technology | |
| CN1057563C (en) | Bacterial stain of bacillus subtilis and application thereof | |
| CN1255036C (en) | Production process of medicinal saccharomycetes fermented tea | |
| CN104846017A (en) | Method for producing fleece-flower root red yeast rice | |
| CN100394928C (en) | Application of Antrodia camphorata mycelium fermented extract in preparation of anti-radiation damage medicine | |
| CN108523112B (en) | Silkworm chrysalis food base material and preparation method and application thereof | |
| CN1065432C (en) | Antilipemic monascus and its preparation | |
| CN1173361A (en) | Medicines contg. red coloring agent for food for bringing down blood pressure and reducing blood sugar and its prepn. method | |
| CN108159199A (en) | A kind of female preparation method for increasing egg and dissipating of the benefit of composite bacteria fermentation | |
| CN1061537C (en) | Monascus preparation for hyperlipemia and relevant cardiac and cerebral diseases | |
| JP5502449B2 (en) | Intestinal flora balance improving agent and method for producing the same | |
| CN1059235C (en) | Preparation of living bacillus subtilis and preparation method thereof | |
| CN1107737A (en) | Active northern cordyceps and its preparation | |
| CN113521262A (en) | Lysozyme preparation with anti-inflammatory effect | |
| CN107412253B (en) | Fomitopsis pinicola compound bacterium tablet | |
| CN1155421A (en) | Preparation of rice fermented with red yeast for curing hyperlipemia and cardio-cerebral diseases concerned | |
| CN1272336C (en) | Method of microeave radiation for preparing holoside in solid phase | |
| CN1327047A (en) | Method for cultivating variotin pecilocin with silkworm and medicinal use | |
| CN1698857A (en) | Medicine with chondriomere distortion preventing function | |
| CN115433703B (en) | Application of capsaicin in promoting proliferation of akkermansia muciniphila |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |