CN1231662A - 喹唑啉衍生物和含有喹唑啉衍生物的药用组合物 - Google Patents
喹唑啉衍生物和含有喹唑啉衍生物的药用组合物 Download PDFInfo
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- CN1231662A CN1231662A CN97198133A CN97198133A CN1231662A CN 1231662 A CN1231662 A CN 1231662A CN 97198133 A CN97198133 A CN 97198133A CN 97198133 A CN97198133 A CN 97198133A CN 1231662 A CN1231662 A CN 1231662A
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- Prior art keywords
- alkyl
- group
- base
- carbamyl
- quinazoline
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/023—Adhesive plasters or dressings wound covering film layers without a fluid handling layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00217—Wound bandages not adhering to the wound
- A61F2013/00221—Wound bandages not adhering to the wound biodegradable, non-irritating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
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- A61F13/84—Accessories, not otherwise provided for, for absorbent pads
- A61F13/8405—Additives, e.g. for odour, disinfectant or pH control
- A61F2013/8408—Additives, e.g. for odour, disinfectant or pH control with odour control
Abstract
Description
Claims (16)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96402033 | 1996-09-25 | ||
EP96402033.3 | 1996-09-25 | ||
EP97401042 | 1997-05-09 | ||
EP97401042.3 | 1997-05-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1231662A true CN1231662A (zh) | 1999-10-13 |
CN1142920C CN1142920C (zh) | 2004-03-24 |
Family
ID=26144073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB971981337A Expired - Lifetime CN1142920C (zh) | 1996-09-25 | 1997-09-23 | 喹唑啉衍生物和及其药用组合物与其制备方法和应用 |
Country Status (33)
Country | Link |
---|---|
US (6) | USRE42353E1 (zh) |
EP (1) | EP0929530B1 (zh) |
JP (3) | JP3438818B2 (zh) |
KR (1) | KR100618065B1 (zh) |
CN (1) | CN1142920C (zh) |
AT (1) | ATE228114T1 (zh) |
AU (1) | AU729968C (zh) |
BR (1) | BR9711302B1 (zh) |
CA (1) | CA2263319C (zh) |
CH (1) | CH0929530H1 (zh) |
CL (1) | CL2004001178A1 (zh) |
CY (1) | CY2453B1 (zh) |
CZ (1) | CZ296962B6 (zh) |
DE (1) | DE69717294C5 (zh) |
DK (1) | DK0929530T3 (zh) |
ES (1) | ES2185999T3 (zh) |
GB (1) | GB9718972D0 (zh) |
HK (1) | HK1019332A1 (zh) |
HU (1) | HU228176B1 (zh) |
IL (1) | IL129038A (zh) |
MY (1) | MY129540A (zh) |
NO (1) | NO313138B1 (zh) |
NZ (1) | NZ334014A (zh) |
PL (1) | PL190326B1 (zh) |
PT (1) | PT929530E (zh) |
RU (1) | RU2198879C2 (zh) |
SI (1) | SI0929530T1 (zh) |
SK (1) | SK283175B6 (zh) |
TR (1) | TR199900674T2 (zh) |
TW (1) | TW520364B (zh) |
UA (1) | UA57752C2 (zh) |
WO (1) | WO1998013354A1 (zh) |
ZA (1) | ZA978553B (zh) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006119673A1 (fr) * | 2005-05-12 | 2006-11-16 | Wenlin Huang | Procede de preparation de derives de quinazoline et application pour la fabrication pour le traitement d’une maladie tumorale |
WO2006119674A1 (fr) * | 2005-05-12 | 2006-11-16 | Wenlin Huang | Procede de preparation de derives de quinazoline et application pour la fabrication pour le traitement d’une maladie tumorale |
WO2006119676A1 (fr) * | 2005-05-12 | 2006-11-16 | Wenlin Huang | Procede de preparation de derives de quinazoline et application pour la fabrication pour le traitement d'une maladie tumorale |
WO2006119675A1 (fr) * | 2005-05-12 | 2006-11-16 | Wenlin Huang | Procede de preparation de derives de quinazoline et application pour la fabrication pour le traitement d'une maladie tumorale |
CN100404517C (zh) * | 2000-08-26 | 2008-07-23 | 贝林格尔英格海姆法玛两合公司 | 双环杂环、含这些化合物的药物组合物,其用途及制备方法 |
CN101659658A (zh) * | 2008-08-29 | 2010-03-03 | 北大方正集团有限公司 | 氰基取代的喹啉衍生物 |
CN101031303B (zh) * | 2004-05-21 | 2011-08-31 | 阿斯利康(瑞典)有限公司 | 包含zd6474的药物组合物 |
CN102503933A (zh) * | 2005-09-30 | 2012-06-20 | 阿斯利康(瑞典)有限公司 | 制备喹唑啉衍生物的化学方法 |
CN102933573A (zh) * | 2010-06-11 | 2013-02-13 | 韩美科学株式会社 | 包含酰胺衍生物或其可药用盐的药物组合物 |
CN101659657B (zh) * | 2008-08-29 | 2014-05-14 | 北大方正集团有限公司 | 氰基取代的喹啉衍生物及其制备方法和用途 |
CN105853434A (zh) * | 2016-04-13 | 2016-08-17 | 李春 | 一种治疗正畸儿童牙龈炎的药物组合物 |
WO2022063229A1 (zh) * | 2020-09-25 | 2022-03-31 | 石药集团中奇制药技术(石家庄)有限公司 | 含芳氨基喹唑啉的化合物的盐及其制备方法和应用 |
CN114948964A (zh) * | 2021-02-25 | 2022-08-30 | 石药集团中奇制药技术(石家庄)有限公司 | 多靶点蛋白激酶抑制剂的用途 |
Families Citing this family (420)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
ATE300521T1 (de) | 1996-09-25 | 2005-08-15 | Astrazeneca Ab | Chinolin-derivate die den effekt von wachstumsfaktoren wie vegf vezögern |
ES2289791T3 (es) | 1997-08-22 | 2008-02-01 | Astrazeneca Ab | Derivados de oxindolilquinazolina como inhibidores de la angiogenesis. |
US6706721B1 (en) | 1998-04-29 | 2004-03-16 | Osi Pharmaceuticals, Inc. | N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate |
US6630488B1 (en) | 1998-09-21 | 2003-10-07 | Biochem Pharma, Inc. | Quinolizinones as integrin inhibitors |
WO2000051991A1 (en) | 1999-02-27 | 2000-09-08 | Boehringer Ingelheim Pharma Kg | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES |
DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
YU13200A (sh) * | 1999-03-31 | 2002-10-18 | Pfizer Products Inc. | Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja |
MXPA01012899A (es) * | 1999-06-21 | 2002-07-30 | Boehringer Ingelheim Pharma | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion. |
ATE377597T1 (de) | 1999-07-09 | 2007-11-15 | Glaxo Group Ltd | Anilinochinazoline als protein-tyrosin- kinasehemmer |
US6933299B1 (en) | 1999-07-09 | 2005-08-23 | Smithkline Beecham Corporation | Anilinoquinazolines as protein tyrosine kinase inhibitors |
EE200200119A (et) | 1999-09-21 | 2003-04-15 | Astrazeneca Ab | Kinasoliini derivaadid ja nende kasutamine ravimitena |
SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
JP3522727B2 (ja) * | 1999-11-05 | 2004-04-26 | アストラゼネカ アクチボラグ | Vegf阻害剤としてのキナゾリン誘導体 |
UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
US7087613B2 (en) | 1999-11-11 | 2006-08-08 | Osi Pharmaceuticals, Inc. | Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride |
US6706731B2 (en) | 2000-02-09 | 2004-03-16 | Novartis Ag | Pyridine derivatives inhibiting angiogenesis and/or VEGF receptor tyrosine kinase |
GB2359551A (en) | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
AU2001235804A1 (en) | 2000-03-06 | 2001-09-17 | Astrazeneca Ab | Therapy |
US20070021392A1 (en) * | 2000-03-31 | 2007-01-25 | Davis Peter D | Divided dose therapies with vascular damaging activity |
GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
ATE334973T1 (de) * | 2000-04-07 | 2006-08-15 | Astrazeneca Ab | Chinazolinverbindungen |
UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
NZ523702A (en) | 2000-08-21 | 2004-08-27 | Astrazeneca Ab | Quinazoline derivatives |
US6403580B1 (en) | 2000-08-26 | 2002-06-11 | Boehringer Ingelheim Pharma Kg | Quinazolines, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
US6617329B2 (en) | 2000-08-26 | 2003-09-09 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines and their use as medicaments |
DE10042061A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen,diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US6656946B2 (en) * | 2000-08-26 | 2003-12-02 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
US6740651B2 (en) | 2000-08-26 | 2004-05-25 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
WO2002030924A1 (en) * | 2000-10-13 | 2002-04-18 | Astrazeneca Ab | Quinazoline derivatives with anti-tumour activity |
SE0003828D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Novel compounds |
ATE502928T1 (de) | 2000-11-01 | 2011-04-15 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
DE60229046D1 (de) * | 2001-04-19 | 2008-11-06 | Astrazeneca Ab | Chinazolin derivate |
WO2002092577A1 (en) * | 2001-05-14 | 2002-11-21 | Astrazeneca Ab | Quinazoline derivatives |
EP1408980A4 (en) | 2001-06-21 | 2004-10-20 | Ariad Pharma Inc | NEW QUINAZOLINES AND THEIR USE |
GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
GB0128108D0 (en) * | 2001-11-23 | 2002-01-16 | Astrazeneca Ab | Therapeutic use |
GB0128109D0 (en) | 2001-11-23 | 2002-01-16 | Astrazeneca Ab | Therapeutic use |
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- 1997-09-23 RU RU99108663/04A patent/RU2198879C2/ru active Protection Beyond IP Right Term
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WO2006119674A1 (fr) * | 2005-05-12 | 2006-11-16 | Wenlin Huang | Procede de preparation de derives de quinazoline et application pour la fabrication pour le traitement d’une maladie tumorale |
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CN101659658A (zh) * | 2008-08-29 | 2010-03-03 | 北大方正集团有限公司 | 氰基取代的喹啉衍生物 |
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CN102933573A (zh) * | 2010-06-11 | 2013-02-13 | 韩美科学株式会社 | 包含酰胺衍生物或其可药用盐的药物组合物 |
CN102933573B (zh) * | 2010-06-11 | 2014-12-24 | 韩美科学株式会社 | 包含酰胺衍生物或其可药用盐的药物组合物 |
CN105853434A (zh) * | 2016-04-13 | 2016-08-17 | 李春 | 一种治疗正畸儿童牙龈炎的药物组合物 |
WO2022063229A1 (zh) * | 2020-09-25 | 2022-03-31 | 石药集团中奇制药技术(石家庄)有限公司 | 含芳氨基喹唑啉的化合物的盐及其制备方法和应用 |
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WO2022179608A1 (zh) * | 2021-02-25 | 2022-09-01 | 石药集团中奇制药技术(石家庄)有限公司 | 多靶点蛋白激酶抑制剂的用途 |
CN114948964B (zh) * | 2021-02-25 | 2023-10-03 | 石药集团中奇制药技术(石家庄)有限公司 | 多靶点蛋白激酶抑制剂的用途 |
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