CN1294881C - 减少相控阵聚焦超声系统中的次热点的系统 - Google Patents

减少相控阵聚焦超声系统中的次热点的系统 Download PDF

Info

Publication number
CN1294881C
CN1294881C CNB018082653A CN01808265A CN1294881C CN 1294881 C CN1294881 C CN 1294881C CN B018082653 A CNB018082653 A CN B018082653A CN 01808265 A CN01808265 A CN 01808265A CN 1294881 C CN1294881 C CN 1294881C
Authority
CN
China
Prior art keywords
frequency
transducer
drive signal
controller
respective drive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB018082653A
Other languages
English (en)
Other versions
CN1449261A (zh
Inventor
舒克·韦特克
纳马·布伦纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tektronix Yinsai Image Guided Treatment Co
InSightec-TxSonics Ltd
Insightec Ltd
Original Assignee
TxSonics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TxSonics Ltd filed Critical TxSonics Ltd
Publication of CN1449261A publication Critical patent/CN1449261A/zh
Application granted granted Critical
Publication of CN1294881C publication Critical patent/CN1294881C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • A61B8/4494—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer characterised by the arrangement of the transducer elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/0207—Driving circuits
    • B06B1/0223—Driving circuits for generating signals continuous in time
    • B06B1/0269—Driving circuits for generating signals continuous in time for generating multiple frequencies
    • B06B1/0284—Driving circuits for generating signals continuous in time for generating multiple frequencies with consecutive, i.e. sequential generation, e.g. with frequency sweep
    • G—PHYSICS
    • G10—MUSICAL INSTRUMENTS; ACOUSTICS
    • G10K—SOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
    • G10K11/00—Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
    • G10K11/18—Methods or devices for transmitting, conducting or directing sound
    • G10K11/26—Sound-focusing or directing, e.g. scanning
    • G10K11/34—Sound-focusing or directing, e.g. scanning using electrical steering of transducer arrays, e.g. beam steering
    • G10K11/341—Circuits therefor
    • G10K11/346—Circuits therefor using phase variation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/0065—Concave transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0073—Ultrasound therapy using multiple frequencies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal

Abstract

利用聚焦超声进行一种治疗操作的系统和方法，包括提供一个由多个换能器元件(例如凹状同心环状或线性阵列的换能器元件)构成的压电换能器。驱动电路同换能器耦合，在某一种无线电频率(RF)下向换能器元件提供驱动信号。一个控制器与驱动电路耦合，用来周期性地把驱动信号的频率进行多种不同的改变，同时控制驱动信号的相位，使得换能器的焦点在一个超声波治疗过程中固定于一个主要的聚焦区。

Description

减少相控阵聚焦超声系统中的次热点的系统
本发明所属技术领域
本发明主要涉及用聚焦超声进行非侵入性外科操作的系统和方法，尤其涉及减少由一种聚焦超声换能器阵列所产生的次热点的系统和方法。
与本发明相关的背景技术
高强度聚焦声波，例如超声波(频率高于约20千赫的声波)，可用于治疗病人位于体内组织区域的病变。例如，超声波可用于切除肿瘤，从而免于进行侵入性的外科手术。为此目的，电信号驱动的产生超声能量的压电换能器被建议置于病人体外但尽量靠近要切除的组织的部位。该换能器按一定的几何形状进行塑形(shaped)和定位，因此超声能量被聚焦于一个与病人体内靶组织部位相对应的“聚焦区”，加热靶组织部位直到使其坏死。该换能器可对位于相近部位的多个病灶进行依次的聚焦和激活。这种系列超声波治疗被用于导致一种完整组织结构的凝结坏死，例如一种有一定大小和形状的肿瘤。
一种球冠换能器阵列，例如在授权Umemura等的美国专利第4,865,042号中所披露的，已建议用于此种用途。这种球冠换能器阵列包括多个置于一个曲面上的同心环，该曲面具有一个限定部分球体的曲率半径。这些同心环通常具有相等的表面积，并且可以沿圆周被分成许多弯曲的换能器元件或区段，来产生扇形-旋涡阵列。这些换能器元件被无线电频率(RF)电信号所驱动，这些电信号是其相位和振幅上偏移的单频信号。特别地，可以控制相应驱动信号的相位和振幅，从而将发射的超声能量聚焦于所希望的“焦距”，即从换能器到聚焦区中心的距离，并提供靶组织部位所需的能量水平。
尽管这些换能器元件被聚焦于一个所希望的主要聚焦区，但在主要聚焦区之外也可能存在一个或多个次聚焦区。例如，在同心环之间的区域可成为这种“热点”，尤其在“邻近区域”，即在换能器和主要聚焦区之间的区域。这种次热点可导致非预期的加热、病人的疼痛、和/或邻近区域组织的可能坏死。因为换能器是由有限数目的环所构成，用于改变环之间的相位的阶跃函数也可能促成次热点的形成。
为最大程度减小次热点的影响，一种解决方案是应用一个宽带频率信号来驱动换能器元件，这样次热点区域可以被这种宽带信号所“模糊”，即能量在病人组织区域的不同部分分散，因而减少了将组织区域加热至使其坏死的危险。然而，这个解决方法可能受换能器带宽的限制并且可能需要特殊的、复杂的电子设备。宽带驱动信号还可使主要聚焦区变得模糊，因而要切除位于主要聚焦区的靶组织，需要更高的超声能量。主要聚焦区的模糊可至少部分地通过导入信号的适当延迟来纠正，但这可能使对相控阵的控制变得相当复杂，例如，需要额外的电子相位调整及调焦。
因此，有必要提供这样的系统和方法，通过一种或多种频率的超声能量来对一个组织区域进行治疗，能够减少次热点，又不会显著降低在主要聚焦区的强度。
发明简述
本发明涉及用聚焦超声进行治疗性操作的系统和方法，该聚焦超声能相当程度地减少次热点的影响，而不会对向主要聚焦区释放能量产生不利影响。
本发明提供了一种用聚焦超声对病人体内的在主要聚焦区内的靶组织区域进行治疗性操作的系统，包括：
一种换能器元件的阵列；
与该换能器元件耦合的驱动电路，该驱动电路设置成至少在第一、第二和第三个离散频率向该换能器元件提供相应的驱动信号；以及
与该驱动电路耦合的控制器，该控制器设定成以至少第一频率、第二频率和第三频率之间周期性地改变由该驱动电路提供的相应驱动信号的频率，同时在一个基本连续的超声波治疗过程中基本保持聚焦于主要聚焦区，该控制器周期性地改变该相应驱动信号的频率，每间隔0.2秒至1.0秒一次。
优选地，其中控制器进一步设置为控制聚焦于换能器元件的相应驱动信号的相位构成，使该换能器元件在第一频率、第二频率和第三频率下基本聚焦于主要聚焦区。
本发明还提供了一种用聚焦超声对病人体内的在主要聚焦区内的靶组织区域进行治疗性操作的系统，包括：
一种换能器元件的阵列；
与该换能器元件耦合的驱动电路，该驱动电路设置成至少以第一和第二个离散频率向换能器元件提供相应的驱动信号；以及
与该驱动电路耦合的控制器，用于在至少第一频率和第二频率之间周期性地改变由驱动电路提供的相应驱动信号的频率，同时在一个基本连续的超声波治疗过程中基本保持聚焦于主要聚焦区，该控制器周期性地改变相应驱动信号的频率，每间隔0.2秒至1.0秒一次。
优选地，其中控制器设定为在一个超声波治疗过程中改变相应驱动信号的频率，使得相应驱动信号的频率变化最多为每间隔1秒1次。
更优选地，其中控制器设定为在一个超声波治疗过程中改变所述相应驱动信号的频率，使得相应驱动信号为间隔0.2～0.5秒的信号。
优选地，其中控制器设定为在一个约为10秒或更长的超声波治疗过程中，将相应驱动信号的频率以预定的顺序在多个离散的频率之间进行变换。
优选地，其中控制器设定为在一个约为5～20秒基本连续的超声波治疗过程中，将所述的相应驱动信号的频率以预定的顺序在多个离散的频率之间进行变换。
优选地，其中控制器进一步设定为控制相应驱动信号的相位构成，使该换能器元件在第一频率和第二频率下基本聚焦于一个主要聚焦区，同时改变在主要聚焦区之外的次聚焦区的位置。
优选地，其中控制器设定为在将相应驱动信号的频率变化之前，以第二频率保持所述相应驱动信号。
在一个优选实施例中，一种聚焦超声系统包括一个由有包括多个换能器元件的压电材料构成的换能器。这些换能器元件的排列或几何形状可以是多种形式的。例如，在一个示范性的具体实施例中，换能器可大致是一个凹状相控阵，包含多个同心环。每个换能器环可沿圆周被分成多个弯曲的元件或“区段”。作为另一种选择，可提供换能器元件的线性阵列。也可提供其它形式的换能器元件的排列或几何形状，比如棋盘状图案、六角点阵、或某种换能器元件的随机排列形式，本发明并不局限于任何一种特定的几何形状。
驱动电路与各个相应的换能器元件耦合，以多种离散频率之一向各个换能器元件提供驱动信号，优选无线电频率。一个控制器与驱动电路耦合，用于在超声波治疗过程中在多个离散频率中的一个频率之间周期性地改变驱动信号的频率。特别地，该控制器决定各个相应驱动信号的相位组成，这样，在离换能器某个预定距离处就产生了具有特定大小和形状的主要聚焦区。
换能器最好可以调节并置于一个箱体内，例如一张注满液体的工作台，病人可置于工作台上面。使用该系统的过程中，多个换能器元件可由一组驱动信号激活，每一个采用一种单频，同时将换能器元件产生的超声能量聚焦于与病人体内的靶组织的位置相对应的主要聚焦区。周期性地，可改变相应驱动信号的频率，而同时基本保持焦点在主要聚焦区。优选地，当驱动信号的频率改变时，通过对驱动信号相位组成的控制来达到这个效果。
这一系列驱动信号提供给换能器来产生一个独立的超声波治疗过程，它可基本切除靶组织区域的组织，同时而最大限度减小次聚焦区或次“热点”的影响。当频率改变时，次热点的位置可产生变化，因而将在次热点的超声能量分散至病人体内的多个部位。因此，当靶组织区域得到足以使组织基本坏死的能量时，次热点处的组织则不会有同样变化。
本发明的其它目的和特征，通过下文结合附图的描述而更为明了。
附图简述
本发明的优选具体实施例是通过附图中的实施例进行描述说明，但并非仅限于此，图中相同的附图标号对应相同的部件，其中：
图1A是根据本发明的一种聚焦超声系统的一个具体实施例的示意图。
图1B是图1A中的聚焦超声系统的换能器阵列的俯视图。
图2是病人躺在一个装有超声换能器阵列的注满水的工作台上的示意侧视图。
图3图示用来驱动一个超声换能器聚焦于一个固定的主要聚焦区的不同频率信号的次热点位置。
优选具体实施例的详细描述
现在来看附图，图1A、图1B、和图2图示了根据本发明的一个系统10的优选具体实施例，其利用聚焦超声进行治疗性操作。系统10通常包括一个换能器12、一个提供电驱动信号15至换能器12的驱动电路14、以及一个对驱动电路14提供的驱动信号15进行控制的控制器16。优选地，该换能器12是一个用压电材料构成的相控阵超声换能器，其构成为本领域技术人士所了解。
在图1A和图1B所示的优选具体实施例中，换能器12可为一种凹状或碗状，例如一种“球冠”状，即有一个基本恒定的曲率半径18，因而换能器12具有限定的球体部分的内表面20。换能器12可划分为多个同心环22-1至22-n(其中n是环的总数)，比如通过压电壳(piezoelectric shell)将同心环进行分割(图中未示出)。优选地，22-1至22-n的每个环具有基本相同的表面积，这样环22从最内层环22-1至最外层环22-n的宽度逐渐变窄。此外，环22的同心环可以具有相等的宽度(图中未示出)，因而每个环22的面积从最内层环到最外层环逐渐增加。环22之间的任何间隔(图中未示出)可用硅橡胶和类似物填充，从而基本上将环22互相隔离。每个环22也可沿圆周被分成弯曲的元件或“区段”23(23-1a至23-1h表示图1B中的最内层环22-1)，例如，可以从换能器12的背面除去每个区段23之间薄的径向电极(图中未示出)。在一个优选具体实施例中，换能器12的外径约为8至12cm，曲率半径18约为8至16cm，以及包括约10至30个环22，其中每个环分成4至16个区段23。
更多的关于适用于本发明的相控阵换能器的构造的信息可参见，例如T.Fjield和K.Hynynen，“The combined Concentric-Ringand Sector-Vortex Phased Array for MR1 Guided Ultrasound Surgery”，IEEE Transactions on Ultrasonics，Ferroelectrics，and FrequencyControl，vol.44，no.5，pages 1157-1167(Sept.1997)，其披露的内容结合于此作为参考。此外，也可以提供没有沿圆周划分成区段的同心环换能器(无图例)。这样的同心环换能器示于，如C.Cain和S.Umemura，“Concentric-Ring and Sector-Vortex Phased-ArrayApplicators for Ultrasound Hyperthermia”，IEEE Transactions onMicrowave Theory and Techniques，vol.MTT-34，no.5，pages542-551(May 1986)一文中，其披露的内容结合于此作为参考。
另一个优选具体实施例(无图例)中，可提供换能器元件的线性阵列，它可聚焦于一个具有某种理想形状(比如一种线状聚焦区)的主要聚焦区。此外，可以提供换能器元件的其它排列方式或几何形状，例如棋盘状图案或六角点阵。换能器元件可备置在弯曲的球冠形换能器、基本扁平状换能器、和类似换能器上，这些换能器可以聚焦于一个主要聚焦区。
回到图1B，环22的每个区段23以常规方式单独地与驱动电路14耦合。使驱动电路14具有一定形状从而多种离散频率下，向区段23提供电驱动信号15，优选频率是无线电频率(RF)，比如在约0.5至10MHz之间，优选为在约1.0至2.0MHz之间。当对区段23提供电驱动信号15时，换能器12从它的内表面20发射超声能量，如本领域人员所知的。
把控制器16与驱动电路14耦合，以控制由驱动电路14产生的驱动信号15的几个方面，比如频率、相位、和振幅。首先，控制器16可控制驱动信号15的振幅，例如，控制由换能器12传递的超声能量的强度。此外，控制器16可控制每个同心环22之间和每个区段23之间的相位。通过在同心环22之间变换相位，则可以沿着z轴调节“焦距”，即从换能器12到聚焦区中心的距离，本领域技术人员所知。
在区段23之间变换相位使得可以控制超声能量的聚焦区的大小和形状，或换能器12的“模式”，这同样为本领域技术人员所了解。关于相控阵换能器相移的更多信息可参见前文所提到的Fiield和Cain的文章，以及授权Umemura等的美国专利第4,865,042号，其披露的内容也结合于此作为参考。
优选地，控制器16也可控制提供给换能器12的驱动信号15的频率。在同一时间传向换能器12的驱动信号15最好全部是同一离散的频率。在一个独立的超声波治疗过程(用时大约为5至20秒，最好在约10秒或更长)中，控制器16可周期性地改变驱动信号15的频率，比如，最长可以间隔1秒，最佳间隔是约0.2至0.5秒。同时，控制器16控制驱动信号15的相位和/或振幅，使得由换能器12产生的超声能量形成的聚焦区保持在病人体内的预定部位。这样，控制器16可指示驱动电路产生连续的多套驱动信号15，每套信号的离散频率都与前一套信号的离散频率不同。
如图2所示，换能器12优选地被置于注满液体的箱体，如工作台30中。工作台30包括一个腔室32，其中装满脱气水或类似的声学传导液体。优选地，换能器12与一定位系统34耦合，该定位系统可在腔室32中移动换能器12，因而机械地调节换能器12形成的聚焦区38。例如，定位系统34可配置为能在三种相互垂直的任一方向上在腔室32中移动换能器12，例如，水平前后、水平左右、以及竖直方向。授权Cline等的美国专利第5,247,935号和授权Ettinger等的美国专利第5,275,165号披露了典型的可采用的定位系统，其披露的内容结合于此作为参考。
此外，定位系统34可简单地使换能器12围绕腔室32内的一个固定点旋转，即来改变换能器12的角度并进而改变聚焦区38相对于一个水平面(图中未示出)的角度。在这种可选择的结构中，换能器12的焦距控制可用电控方式，如前所述，其控制是通过改变提供给换能器12的驱动信号15的相位和/或振幅来实现的。在其它可选结构中，定位系统34可以将换能器12在垂直于传播方向(图中未示出)的水平面上移动，可采用电控其深度，或可以使用其它的机械和电子定位系统的结合。
工作台30的顶部包括一个可透过超声的柔软膜36、比如一种聚酯薄膜塑料或聚氯乙烯(PVC)膜。沿工作台的顶部通常铺有一个装满液体的袋子或垫子，其形状易随躺在工作台上的病人身体的轮廓而改变。在另外一种可选结构中，换能器12可装在一个充满液体的置于一个可移动支臂上(图中未示出)的袋子中，该袋子可以放置在与病人相接触的位置，如在美国专利第5,526,814号中所披露的，其披露的内容结合于此作为参考。
另外，系统10可包括一个成像装置(图中未示出)，用于在治疗病人的过程中对该系统的使用进行监视。例如，系统10可置于一个磁共振成像装置(MRI)中，如在授权Cline等的美国专利第5,247,935、5,291,890、5,368,031、5,368,032、5,443,068号和授权Hardy等的美国专利第5,307,812、5,323,779、5,327,884号中所披露的磁共振成像装置，其披露的内容结合于此作为参考。
再看图2，在使用过程中，一个病人40可位于工作台30之上，用水、超声传导性凝胶、和类似物涂布在病人40和袋子或膜36之间，因而将病人40同换能器12进行声学上的耦合。换能器12可聚焦于某种组织结构42中的一个靶组织区域，例如可能是一个恶性或良性肿瘤。换能器12可被一套具有离散频率的驱动信号15所激发，将超声能量聚焦于靶组织区域42。在超声波治疗过程中，驱动信号15的频率可周期性地改变，如前面所述，同时维持焦点在靶组织区域42。换能器12可被激活足够长的时间以使靶组织区域42足以坏死，例如，在约5至20秒之间，约10秒或更长时间则更佳。
换能器12可以停止激活足够的时间，用来消散病人的组织所吸收的热量，例如，在约45至90秒之间，约60秒或更长时间则更好。然后，换能器12可聚焦于另一个靶组织区域(图中未示出)，比方说邻近靶组织区域42的靶组织区域，重复该程序直到整个靶组织结构都被烧融。
根据本发明的一种系统利用控制驱动信号的频率，优选地在一个连续的超声波治疗过程中，来减少次热点的影响。因为主要和次要聚焦区的位置都随驱动信号的改变而发生变化，当频率改变时，不同频率的驱动信号可使得换能器产生的聚焦区或“热点”在病人体内移动至不同的位置或焦距。根据本发明的一种系统的控制器可改变频率，但通过同时调节提供给换能器元件的驱动信号的相位和/或振幅，能够使超声能量的主要聚焦区基本保持在病人体内的某个靶组织区域。然而，次热点不会保持在相同的位置，而是随着频率的改变而聚焦于不同的位置。
这在例如图3中加以说明，图3表示一个换能器产生的能量强度(单位是W/m2)与离换能器距离(z)的关系。在此实施例中，换能器聚焦于约150mm的焦距，而驱动信号的频率则从1.3MHz变为1.5MHz、又变为1.7MHz。从三个相应曲线中可看出，次热点距换能器的距离从1.3MHz时的约55mm，变为1.5MHz时的约60mm，又变为1.7MHz时的约65mm。因而，在次热点产生的能量随着频率的变化而被不同的组织区域所吸收。这样分散了能量，充分减少了将次热点处的组织加热至引起疼痛、导致组织损伤或坏死的危险。因为主要聚焦区基本维持在一个固定焦距处，主要聚焦区处的组织可被充分加热直至坏死。
本发明可被进行多种修改并采用其它可选形式，其特定实施例已在此处用图例表示并进行了详细描述。然而，应该明了的是，本发明并不局限于所披露的特殊形式或方法，与之相反，本发明可涵盖所附权利要求书范围内的所有修改、等效结构和可替代的选择。

Claims (9)

1.一种用聚焦超声对病人体内的在主要聚焦区内的靶组织区域进行治疗性操作的系统，包括：
一种换能器元件的阵列；
与所述换能器元件耦合的驱动电路，所述驱动电路设置成至少以第一、第二和第三个离散频率向所述换能器元件提供相应的驱动信号；以及
与所述驱动电路耦合的控制器，所述控制器设定成在至少所述第一频率、所述第二频率和第三频率之间周期性地改变由所述驱动电路提供的所述相应驱动信号的频率，同时在一个基本连续的超声波治疗过程中基本保持聚焦于所述主要聚焦区，所述控制器周期性地改变所述相应驱动信号的频率，每间隔0.2秒至1.0秒一次。
2.根据权利要求1所述的系统，其中所述控制器进一步设置为控制聚焦于所述换能器元件的所述相应驱动信号的相位构成，使所述换能器元件在所述第一频率、所述第二频率和所述第三频率下基本聚焦于所述主要聚焦区。
3.一种用聚焦超声对病人体内的在主要聚焦区内的靶组织区域进行治疗性操作的系统，包括：
一种换能器元件的阵列；
与所述换能器元件耦合的驱动电路，所述驱动电路设置成至少以第一和第二个离散频率向所述换能器元件提供相应的驱动信号；以及
与所述驱动电路耦合的控制器，用于在至少所述第一频率和所述第二频率之间周期性地改变由所述驱动电路提供的所述相应驱动信号的频率，同时在一个基本连续的超声波治疗过程中基本保持聚焦于所述主要聚焦区，所述控制器周期性地改变所述相应驱动信号的频率，每间隔0.2秒至1.0秒一次。
4.根据权利要求3所述的系统，其中所述控制器设定为在一个超声波治疗过程中改变所述相应驱动信号的频率，使得所述相应驱动信号的频率变化最多为每间隔1秒1次。
5.根据权利要求4所述的系统，其中所述控制器设定为在一个超声波治疗过程中改变所述相应驱动信号的频率，使得所述相应驱动信号为间隔0.2～0.5秒的信号。
6.根据权利要求3所述的系统，其中所述控制器设定为在一个为10秒或更长的超声波治疗过程中，将所述的相应驱动信号的频率以预定的顺序在多个离散的频率之间进行变换。
7.根据权利要求3所述的系统，其中所述控制器设定为在一个为5～20秒基本连续的超声波治疗过程中，将所述的相应驱动信号的频率以预定的顺序在多个离散的频率之间进行变换。
8.根据权利要求3所述的系统，其中所述控制器进一步设定为控制所述相应驱动信号的相位构成，使所述换能器元件在所述第一频率和所述第二频率下基本聚焦于一个主要聚焦区，同时改变在所述主要聚焦区之外的次聚焦区的位置。
9.根据权利要求3所述的系统，其中所述控制器设定为在将所述相应驱动信号的频率变化之前，以所述第二频率保持所述相应驱动信号。
CNB018082653A 2000-04-21 2001-04-12 减少相控阵聚焦超声系统中的次热点的系统 Expired - Lifetime CN1294881C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/556,095 US6419648B1 (en) 2000-04-21 2000-04-21 Systems and methods for reducing secondary hot spots in a phased array focused ultrasound system
US09/556,095 2000-04-21

Publications (2)

Publication Number Publication Date
CN1449261A CN1449261A (zh) 2003-10-15
CN1294881C true CN1294881C (zh) 2007-01-17

Family

ID=24219875

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018082653A Expired - Lifetime CN1294881C (zh) 2000-04-21 2001-04-12 减少相控阵聚焦超声系统中的次热点的系统

Country Status (8)

Country Link
US (1) US6419648B1 (zh)
EP (1) EP1274348B8 (zh)
JP (1) JP2004511268A (zh)
CN (1) CN1294881C (zh)
AT (1) ATE373988T1 (zh)
AU (1) AU2001250617A1 (zh)
DE (1) DE60130642T2 (zh)
WO (1) WO2001080708A2 (zh)

Families Citing this family (244)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6161543A (en) 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
US6409722B1 (en) 1998-07-07 2002-06-25 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US5897553A (en) 1995-11-02 1999-04-27 Medtronic, Inc. Ball point fluid-assisted electrocautery device
US6719755B2 (en) 1996-10-22 2004-04-13 Epicor Medical, Inc. Methods and devices for ablation
US6311692B1 (en) * 1996-10-22 2001-11-06 Epicor, Inc. Apparatus and method for diagnosis and therapy of electrophysiological disease
US7052493B2 (en) * 1996-10-22 2006-05-30 Epicor Medical, Inc. Methods and devices for ablation
US6805128B1 (en) 1996-10-22 2004-10-19 Epicor Medical, Inc. Apparatus and method for ablating tissue
US6096037A (en) 1997-07-29 2000-08-01 Medtronic, Inc. Tissue sealing electrosurgery device and methods of sealing tissue
US6050943A (en) 1997-10-14 2000-04-18 Guided Therapy Systems, Inc. Imaging, therapy, and temperature monitoring ultrasonic system
US8709007B2 (en) 1997-10-15 2014-04-29 St. Jude Medical, Atrial Fibrillation Division, Inc. Devices and methods for ablating cardiac tissue
US6537248B2 (en) 1998-07-07 2003-03-25 Medtronic, Inc. Helical needle apparatus for creating a virtual electrode used for the ablation of tissue
US6706039B2 (en) 1998-07-07 2004-03-16 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US8308719B2 (en) 1998-09-21 2012-11-13 St. Jude Medical, Atrial Fibrillation Division, Inc. Apparatus and method for ablating tissue
EP1207788A4 (en) 1999-07-19 2009-12-09 St Jude Medical Atrial Fibrill FABRIC ABLATION TECHNIQUES AND CORRESPONDING DEVICE
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US8221402B2 (en) 2000-01-19 2012-07-17 Medtronic, Inc. Method for guiding a medical device
US8048070B2 (en) 2000-03-06 2011-11-01 Salient Surgical Technologies, Inc. Fluid-assisted medical devices, systems and methods
US6514250B1 (en) 2000-04-27 2003-02-04 Medtronic, Inc. Suction stabilized epicardial ablation devices
WO2001082812A1 (en) 2000-04-27 2001-11-08 Medtronic, Inc. Vibration sensitive ablation apparatus and method
US8256430B2 (en) 2001-06-15 2012-09-04 Monteris Medical, Inc. Hyperthermia treatment and probe therefor
US6926669B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US6589174B1 (en) * 2000-10-20 2003-07-08 Sunnybrook & Women's College Health Sciences Centre Technique and apparatus for ultrasound therapy
US6618620B1 (en) 2000-11-28 2003-09-09 Txsonics Ltd. Apparatus for controlling thermal dosing in an thermal treatment system
US6506154B1 (en) 2000-11-28 2003-01-14 Insightec-Txsonics, Ltd. Systems and methods for controlling a phased array focused ultrasound system
US7914453B2 (en) 2000-12-28 2011-03-29 Ardent Sound, Inc. Visual imaging system for ultrasonic probe
US7740623B2 (en) 2001-01-13 2010-06-22 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US20040138621A1 (en) 2003-01-14 2004-07-15 Jahns Scott E. Devices and methods for interstitial injection of biologic agents into tissue
US6807968B2 (en) 2001-04-26 2004-10-26 Medtronic, Inc. Method and system for treatment of atrial tachyarrhythmias
US7959626B2 (en) 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US6699240B2 (en) 2001-04-26 2004-03-02 Medtronic, Inc. Method and apparatus for tissue ablation
US6663627B2 (en) 2001-04-26 2003-12-16 Medtronic, Inc. Ablation system and method of use
US6735461B2 (en) * 2001-06-19 2004-05-11 Insightec-Txsonics Ltd Focused ultrasound system with MRI synchronization
EP1435867B1 (en) 2001-09-05 2010-11-17 Salient Surgical Technologies, Inc. Fluid-assisted medical devices and systems
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US7118566B2 (en) 2002-05-16 2006-10-10 Medtronic, Inc. Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
US7294143B2 (en) 2002-05-16 2007-11-13 Medtronic, Inc. Device and method for ablation of cardiac tissue
US7909782B2 (en) * 2002-10-28 2011-03-22 John Perrier Ultrasonic medical device
US7083620B2 (en) 2002-10-30 2006-08-01 Medtronic, Inc. Electrosurgical hemostat
US8088067B2 (en) 2002-12-23 2012-01-03 Insightec Ltd. Tissue aberration corrections in ultrasound therapy
JP2006521902A (ja) * 2003-03-31 2006-09-28 ライポソニックス， インコーポレイテッド 渦型トランスデューサー
US7497857B2 (en) 2003-04-29 2009-03-03 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US7611462B2 (en) 2003-05-22 2009-11-03 Insightec-Image Guided Treatment Ltd. Acoustic beam forming in phased arrays including large numbers of transducer elements
SE526718C2 (sv) * 2003-06-04 2005-10-25 Ultrazonix Dnt Ab Ultraljudssond med en central öppning
US7311701B2 (en) * 2003-06-10 2007-12-25 Cierra, Inc. Methods and apparatus for non-invasively treating atrial fibrillation using high intensity focused ultrasound
JP2005027752A (ja) * 2003-07-08 2005-02-03 Toshiba Corp 圧電振動子、圧電振動子の製造方法、超音波探触子および超音波診断装置
US7611465B2 (en) * 2003-07-15 2009-11-03 Board Of Regents, The University Of Texas System Rapid and accurate detection of bone quality using ultrasound critical angle reflectometry
AU2004272023B2 (en) * 2003-09-08 2008-06-26 Board Of Trustees Of The University Of Arkansas Ultrasound apparatus and method for augmented clot lysis
US20050154308A1 (en) 2003-12-30 2005-07-14 Liposonix, Inc. Disposable transducer seal
AU2004311459B2 (en) * 2003-12-30 2011-07-14 Medicis Technologies Corporation Ultrasound therapy head with movement control
US7857773B2 (en) * 2003-12-30 2010-12-28 Medicis Technologies Corporation Apparatus and methods for the destruction of adipose tissue
US20050154309A1 (en) * 2003-12-30 2005-07-14 Liposonix, Inc. Medical device inline degasser
US20050193451A1 (en) * 2003-12-30 2005-09-01 Liposonix, Inc. Articulating arm for medical procedures
US7993289B2 (en) * 2003-12-30 2011-08-09 Medicis Technologies Corporation Systems and methods for the destruction of adipose tissue
US8337407B2 (en) * 2003-12-30 2012-12-25 Liposonix, Inc. Articulating arm for medical procedures
US8235909B2 (en) 2004-05-12 2012-08-07 Guided Therapy Systems, L.L.C. Method and system for controlled scanning, imaging and/or therapy
US8333764B2 (en) 2004-05-12 2012-12-18 Medtronic, Inc. Device and method for determining tissue thickness and creating cardiac ablation lesions
ES2308505T3 (es) 2004-05-14 2008-12-01 Medtronic, Inc. Sistema de utilizacion de energia ultrasonica enfocada de alta intens idad para formar una zona de tejido recortado.
EP1750607A2 (en) 2004-06-02 2007-02-14 Medtronic, Inc. Loop ablation apparatus and method
DE602005021096D1 (de) 2004-06-02 2010-06-17 Medtronic Inc Zusammengesetzte bipolare ablationsvorrichtung
WO2005120377A1 (en) 2004-06-02 2005-12-22 Medtronic, Inc. Clamping ablation tool
EP1750608B1 (en) 2004-06-02 2012-10-03 Medtronic, Inc. Ablation device with jaws
US8926635B2 (en) 2004-06-18 2015-01-06 Medtronic, Inc. Methods and devices for occlusion of an atrial appendage
US8409219B2 (en) 2004-06-18 2013-04-02 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US8663245B2 (en) 2004-06-18 2014-03-04 Medtronic, Inc. Device for occlusion of a left atrial appendage
US7645244B2 (en) * 2004-07-09 2010-01-12 Boston Scientific Scimed, Inc. Ultrasound systems and methods for treating ischemic limbs or tissue affected by peripheral arterial disease
US7699780B2 (en) * 2004-08-11 2010-04-20 Insightec—Image-Guided Treatment Ltd. Focused ultrasound system with adaptive anatomical aperture shaping
US8409099B2 (en) * 2004-08-26 2013-04-02 Insightec Ltd. Focused ultrasound system for surrounding a body tissue mass and treatment method
US7824348B2 (en) 2004-09-16 2010-11-02 Guided Therapy Systems, L.L.C. System and method for variable depth ultrasound treatment
US7393325B2 (en) 2004-09-16 2008-07-01 Guided Therapy Systems, L.L.C. Method and system for ultrasound treatment with a multi-directional transducer
US9011336B2 (en) 2004-09-16 2015-04-21 Guided Therapy Systems, Llc Method and system for combined energy therapy profile
US8535228B2 (en) 2004-10-06 2013-09-17 Guided Therapy Systems, Llc Method and system for noninvasive face lifts and deep tissue tightening
US10864385B2 (en) 2004-09-24 2020-12-15 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US8444562B2 (en) 2004-10-06 2013-05-21 Guided Therapy Systems, Llc System and method for treating muscle, tendon, ligament and cartilage tissue
US9827449B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US7758524B2 (en) 2004-10-06 2010-07-20 Guided Therapy Systems, L.L.C. Method and system for ultra-high frequency ultrasound treatment
US9694212B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, Llc Method and system for ultrasound treatment of skin
US8690778B2 (en) 2004-10-06 2014-04-08 Guided Therapy Systems, Llc Energy-based tissue tightening
US11883688B2 (en) 2004-10-06 2024-01-30 Guided Therapy Systems, Llc Energy based fat reduction
US20060111744A1 (en) 2004-10-13 2006-05-25 Guided Therapy Systems, L.L.C. Method and system for treatment of sweat glands
EP2279696A3 (en) * 2004-10-06 2014-02-26 Guided Therapy Systems, L.L.C. Method and system for non-invasive mastopexy
US7530356B2 (en) * 2004-10-06 2009-05-12 Guided Therapy Systems, Inc. Method and system for noninvasive mastopexy
US11235179B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc Energy based skin gland treatment
US8133180B2 (en) 2004-10-06 2012-03-13 Guided Therapy Systems, L.L.C. Method and system for treating cellulite
KR101732144B1 (ko) 2004-10-06 2017-05-02 가이디드 테라피 시스템스, 엘.엘.씨. 초음파 치료 시스템
US11207548B2 (en) 2004-10-07 2021-12-28 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US11724133B2 (en) 2004-10-07 2023-08-15 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US20060079868A1 (en) * 2004-10-07 2006-04-13 Guided Therapy Systems, L.L.C. Method and system for treatment of blood vessel disorders
US7918795B2 (en) 2005-02-02 2011-04-05 Gynesonics, Inc. Method and device for uterine fibroid treatment
US7571336B2 (en) 2005-04-25 2009-08-04 Guided Therapy Systems, L.L.C. Method and system for enhancing safety with medical peripheral device by monitoring if host computer is AC powered
US8932208B2 (en) 2005-05-26 2015-01-13 Maquet Cardiovascular Llc Apparatus and methods for performing minimally-invasive surgical procedures
US20070016039A1 (en) 2005-06-21 2007-01-18 Insightec-Image Guided Treatment Ltd. Controlled, non-linear focused ultrasound treatment
US8057408B2 (en) * 2005-09-22 2011-11-15 The Regents Of The University Of Michigan Pulsed cavitational ultrasound therapy
US20070083120A1 (en) * 2005-09-22 2007-04-12 Cain Charles A Pulsed cavitational ultrasound therapy
US10219815B2 (en) 2005-09-22 2019-03-05 The Regents Of The University Of Michigan Histotripsy for thrombolysis
DE102005053918A1 (de) * 2005-11-11 2007-05-16 Zimmer Elektromedizin Gmbh Verfahren und Vorrichtung zur Einstrahlung von Ultraschall in Gewebe
CN101313354B (zh) 2005-11-23 2012-02-15 因赛泰克有限公司 超高密度超声阵列中的分级切换
US9357977B2 (en) * 2006-01-12 2016-06-07 Gynesonics, Inc. Interventional deployment and imaging system
US10058342B2 (en) 2006-01-12 2018-08-28 Gynesonics, Inc. Devices and methods for treatment of tissue
US20070161905A1 (en) * 2006-01-12 2007-07-12 Gynesonics, Inc. Intrauterine ultrasound and method for use
US11259825B2 (en) 2006-01-12 2022-03-01 Gynesonics, Inc. Devices and methods for treatment of tissue
US7815571B2 (en) * 2006-04-20 2010-10-19 Gynesonics, Inc. Rigid delivery systems having inclined ultrasound and needle
US7874986B2 (en) 2006-04-20 2011-01-25 Gynesonics, Inc. Methods and devices for visualization and ablation of tissue
US20100056926A1 (en) * 2008-08-26 2010-03-04 Gynesonics, Inc. Ablation device with articulated imaging transducer
US10595819B2 (en) 2006-04-20 2020-03-24 Gynesonics, Inc. Ablation device with articulated imaging transducer
US8206300B2 (en) 2008-08-26 2012-06-26 Gynesonics, Inc. Ablation device with articulated imaging transducer
US8235901B2 (en) 2006-04-26 2012-08-07 Insightec, Ltd. Focused ultrasound system with far field tail suppression
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
FR2903316B1 (fr) * 2006-07-05 2009-06-26 Edap S A Sonde de therapie et appareil de therapie incluant une telle sonde
US9566454B2 (en) 2006-09-18 2017-02-14 Guided Therapy Systems, Llc Method and sysem for non-ablative acne treatment and prevention
US9241683B2 (en) 2006-10-04 2016-01-26 Ardent Sound Inc. Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid
US20080125653A1 (en) * 2006-11-27 2008-05-29 Board Of Regents, The University Of Texas System Density and porosity measurements by ultrasound
US20100056925A1 (en) * 2006-11-28 2010-03-04 Chongqing Ronghai Medical Ultrasound Industry Ltd. Ultrasonic Therapeutic Device Capable of Multipoint Transmitting
JP5670635B2 (ja) * 2006-11-28 2015-02-18 コーニンクレッカ フィリップス エヌ ヴェ ３ｄ超音波撮像及びセラピーに対する装置
US8142200B2 (en) * 2007-03-26 2012-03-27 Liposonix, Inc. Slip ring spacer and method for its use
US9314298B2 (en) 2007-04-17 2016-04-19 St. Jude Medical, Atrial Fibrillation Divisions, Inc. Vacuum-stabilized ablation system
DK2152167T3 (en) 2007-05-07 2018-12-10 Guided Therapy Systems Llc Methods and systems for coupling and focusing acoustic energy using a coupling element
TWI526233B (zh) 2007-05-07 2016-03-21 指導治療系統股份有限公司 利用聲波能量調製藥劑輸送及效能之系統
US20150174388A1 (en) 2007-05-07 2015-06-25 Guided Therapy Systems, Llc Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue
US8251908B2 (en) 2007-10-01 2012-08-28 Insightec Ltd. Motion compensated image-guided focused ultrasound therapy system
WO2009045265A1 (en) 2007-10-05 2009-04-09 Maquet Cardiovascular, Llc Devices and methods for minimally-invasive surgical procedures
US8088072B2 (en) 2007-10-12 2012-01-03 Gynesonics, Inc. Methods and systems for controlled deployment of needles in tissue
US20090240146A1 (en) * 2007-10-26 2009-09-24 Liposonix, Inc. Mechanical arm
WO2009086448A1 (en) 2007-12-28 2009-07-09 Salient Surgical Technologies, Inc. Fluid-assisted electrosurgical devices, methods and systems
KR20100120188A (ko) 2008-02-01 2010-11-12 메디시스 테크놀로지스 코포레이션 초음파 시스템을 이용한 치료 헤드
EP2092916A1 (en) * 2008-02-19 2009-08-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) A method of treating an ocular pathology by applying high intensity focused ultrasound and device thereof
US20090287081A1 (en) * 2008-04-29 2009-11-19 Gynesonics , Inc Submucosal fibroid ablation for the treatment of menorrhagia
WO2009140359A2 (en) 2008-05-13 2009-11-19 Medtronic, Inc. Tissue lesion evaluation
DK2282675T3 (en) 2008-06-06 2016-05-17 Ulthera Inc Cosmetic treatment and imaging system
US8425424B2 (en) 2008-11-19 2013-04-23 Inightee Ltd. Closed-loop clot lysis
US8585618B2 (en) * 2008-12-22 2013-11-19 Cutera, Inc. Broad-area irradiation of small near-field targets using ultrasound
CA2748362A1 (en) 2008-12-24 2010-07-01 Michael H. Slayton Methods and systems for fat reduction and/or cellulite treatment
HUE026714T2 (en) 2008-12-25 2016-07-28 Brother Ind Ltd Tape cassette and tape printer
EP2370264B1 (en) 2008-12-25 2014-08-27 Brother Kogyo Kabushiki Kaisha Tape cassette and tape printer
US9254168B2 (en) 2009-02-02 2016-02-09 Medtronic Advanced Energy Llc Electro-thermotherapy of tissue using penetrating microelectrode array
EP2398432B1 (en) 2009-02-18 2017-09-06 Eye Tech Care Ultrasound device comprising means to generate ultrasound beam presenting a concave segment shape having a single curvature
AU2009340220B2 (en) * 2009-02-18 2013-07-18 Eye Tech Care Ultrasound device comprising means to generate ultrasound beam presenting a concave segment shape having a single curvature
JP5592409B2 (ja) 2009-02-23 2014-09-17 サリエント・サージカル・テクノロジーズ・インコーポレーテッド 流体支援電気手術デバイスおよびその使用方法
US8262574B2 (en) 2009-02-27 2012-09-11 Gynesonics, Inc. Needle and tine deployment mechanism
US9108037B2 (en) * 2009-03-09 2015-08-18 St. Jude Medical, Atrial Fibrillation Division, Inc. Apparatus and method for tissue ablation with near-field cooling
EP2415612B1 (en) 2009-03-31 2019-09-25 Brother Kogyo Kabushiki Kaisha Tape cassette
CN101850662B (zh) 2009-03-31 2015-02-11 兄弟工业株式会社 带式打印装置
CN102361758B (zh) 2009-03-31 2015-11-25 兄弟工业株式会社 带盒
EP3106314B1 (en) 2009-03-31 2022-04-27 Brother Kogyo Kabushiki Kaisha Tape cassette and tape printer
US8617073B2 (en) 2009-04-17 2013-12-31 Insightec Ltd. Focusing ultrasound into the brain through the skull by utilizing both longitudinal and shear waves
US20100286518A1 (en) * 2009-05-11 2010-11-11 General Electric Company Ultrasound system and method to deliver therapy based on user defined treatment spaces
US20100286520A1 (en) * 2009-05-11 2010-11-11 General Electric Company Ultrasound system and method to determine mechanical properties of a target region
US20100286519A1 (en) * 2009-05-11 2010-11-11 General Electric Company Ultrasound system and method to automatically identify and treat adipose tissue
WO2011001487A1 (en) 2009-06-30 2011-01-06 Brother Kogyo Kabushiki Kaisha Tape cassette and tape printer
US9623266B2 (en) 2009-08-04 2017-04-18 Insightec Ltd. Estimation of alignment parameters in magnetic-resonance-guided ultrasound focusing
AU2010284313B2 (en) 2009-08-17 2016-01-28 Histosonics, Inc. Disposable acoustic coupling medium container
EP2467108B1 (en) * 2009-08-18 2020-01-08 Eye Tech Care Parameters for an ultrasound device comprising means to generate high intensity ultrasound beam
US9289154B2 (en) * 2009-08-19 2016-03-22 Insightec Ltd. Techniques for temperature measurement and corrections in long-term magnetic resonance thermometry
WO2011028603A2 (en) 2009-08-26 2011-03-10 The Regents Of The University Of Michigan Micromanipulator control arm for therapeutic and imaging ultrasound transducers
US9177543B2 (en) 2009-08-26 2015-11-03 Insightec Ltd. Asymmetric ultrasound phased-array transducer for dynamic beam steering to ablate tissues in MRI
JP5726191B2 (ja) 2009-08-26 2015-05-27 リージェンツ オブ ザ ユニバーシティー オブ ミシガン 尿管結石の破砕の際に気泡混濁空洞現象の制御を使用する装置および方法
JP2013503723A (ja) 2009-09-08 2013-02-04 サリエント・サージカル・テクノロジーズ・インコーポレーテッド 電気手術デバイスのためのカートリッジアセンブリ、電気手術ユニット、およびそれらの使用方法
US8539813B2 (en) 2009-09-22 2013-09-24 The Regents Of The University Of Michigan Gel phantoms for testing cavitational ultrasound (histotripsy) transducers
EP2489034B1 (en) 2009-10-14 2016-11-30 Insightec Ltd. Mapping ultrasound transducers
US8368401B2 (en) 2009-11-10 2013-02-05 Insightec Ltd. Techniques for correcting measurement artifacts in magnetic resonance thermometry
US8715186B2 (en) 2009-11-24 2014-05-06 Guided Therapy Systems, Llc Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
JP5212550B2 (ja) 2009-12-16 2013-06-19 ブラザー工業株式会社 テープカセット
EP2520437B1 (en) 2009-12-28 2015-05-20 Brother Kogyo Kabushiki Kaisha Tape cassette
KR101173276B1 (ko) 2010-01-18 2012-08-13 주식회사 휴먼스캔 초음파 프로브
WO2011112991A1 (en) 2010-03-11 2011-09-15 Salient Surgical Technologies, Inc. Bipolar electrosurgical cutter with position insensitive return electrode contact
CN102210910B (zh) * 2010-04-02 2013-02-13 重庆融海超声医学工程研究中心有限公司 一种超声换能器
US8932237B2 (en) 2010-04-28 2015-01-13 Insightec, Ltd. Efficient ultrasound focusing
US9852727B2 (en) 2010-04-28 2017-12-26 Insightec, Ltd. Multi-segment ultrasound transducers
US20110295249A1 (en) * 2010-05-28 2011-12-01 Salient Surgical Technologies, Inc. Fluid-Assisted Electrosurgical Devices, and Methods of Manufacture Thereof
US9138289B2 (en) 2010-06-28 2015-09-22 Medtronic Advanced Energy Llc Electrode sheath for electrosurgical device
US8920417B2 (en) 2010-06-30 2014-12-30 Medtronic Advanced Energy Llc Electrosurgical devices and methods of use thereof
US8906012B2 (en) 2010-06-30 2014-12-09 Medtronic Advanced Energy Llc Electrosurgical devices with wire electrode
KR20200004466A (ko) 2010-08-02 2020-01-13 가이디드 테라피 시스템스, 엘.엘.씨. 초음파 치료 시스템 및 방법
US9504446B2 (en) 2010-08-02 2016-11-29 Guided Therapy Systems, Llc Systems and methods for coupling an ultrasound source to tissue
US9981148B2 (en) 2010-10-22 2018-05-29 Insightec, Ltd. Adaptive active cooling during focused ultrasound treatment
US9023040B2 (en) 2010-10-26 2015-05-05 Medtronic Advanced Energy Llc Electrosurgical cutting devices
US8857438B2 (en) 2010-11-08 2014-10-14 Ulthera, Inc. Devices and methods for acoustic shielding
US8485974B2 (en) * 2010-11-15 2013-07-16 National Health Research Institutes Multiple-frequency ultrasonic phased array driving system
US9079011B2 (en) * 2011-01-03 2015-07-14 Wisconsin Alumni Research Foundation Microwave hyperthermia treatment system
US9427281B2 (en) 2011-03-11 2016-08-30 Medtronic Advanced Energy Llc Bronchoscope-compatible catheter provided with electrosurgical device
EP2686094A4 (en) * 2011-03-17 2014-12-17 Covaris Inc ACOUSTIC PROCESSING CONTAINER AND METHOD FOR ACOUSTIC PROCESSING
US9452302B2 (en) 2011-07-10 2016-09-27 Guided Therapy Systems, Llc Systems and methods for accelerating healing of implanted material and/or native tissue
KR20140047709A (ko) 2011-07-11 2014-04-22 가이디드 테라피 시스템스, 엘.엘.씨. 조직에 초음파원을 연결하는 시스템 및 방법
US9144694B2 (en) 2011-08-10 2015-09-29 The Regents Of The University Of Michigan Lesion generation through bone using histotripsy therapy without aberration correction
CN102319485B (zh) * 2011-08-19 2014-05-14 陈明 一种聚焦定位治疗装置及其系统
WO2013040451A2 (en) 2011-09-15 2013-03-21 Sigma Instruments Holdings, Llc System and method for treating animals
US9782324B2 (en) 2011-09-15 2017-10-10 Sigma Instruments Holdings, Llc System and method for treating skin and underlying tissues for improved health, function and/or appearance
US9861547B2 (en) 2011-09-15 2018-01-09 Sigma Instruments Holdings, Llc Systems and methods for preventing, managing and/or treating peripheral neuropathy, peripheral vascular disease, erectile dysfunction, urinary incontinence, cellulite and other conditions
US9750565B2 (en) 2011-09-30 2017-09-05 Medtronic Advanced Energy Llc Electrosurgical balloons
AU2012326218B2 (en) 2011-10-17 2017-03-09 Butterfly Network, Inc. Transmissive imaging and related apparatus and methods
US8870864B2 (en) 2011-10-28 2014-10-28 Medtronic Advanced Energy Llc Single instrument electrosurgery apparatus and its method of use
EP2799112A4 (en) * 2011-12-29 2015-11-04 Alpinion Medical Systems Co BEAM FORMING APPARATUS AND METHOD FOR IMPROVING BEAM FORMING RESOLUTION
US9517349B2 (en) 2012-01-17 2016-12-13 Sigma Instruments Holdings, Llc System and method for treating soft tissue with force impulse and electrical stimulation
KR20130088478A (ko) * 2012-01-31 2013-08-08 삼성전자주식회사 초음파 트랜스듀서 어레이의 다중 초점 형성 방법 및 장치.
US9263663B2 (en) 2012-04-13 2016-02-16 Ardent Sound, Inc. Method of making thick film transducer arrays
US9049783B2 (en) 2012-04-13 2015-06-02 Histosonics, Inc. Systems and methods for obtaining large creepage isolation on printed circuit boards
EP2844343B1 (en) 2012-04-30 2018-11-21 The Regents Of The University Of Michigan Ultrasound transducer manufacturing using rapid-prototyping method
US9226792B2 (en) 2012-06-12 2016-01-05 Medtronic Advanced Energy Llc Debridement device and method
WO2014003855A1 (en) 2012-06-27 2014-01-03 Monteris Medical Corporation Image-guided therapy of a tissue
US9510802B2 (en) 2012-09-21 2016-12-06 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
US20140100459A1 (en) 2012-10-05 2014-04-10 The Regents Of The University Of Michigan Bubble-induced color doppler feedback during histotripsy
US11234760B2 (en) 2012-10-05 2022-02-01 Medtronic Advanced Energy Llc Electrosurgical device for cutting and removing tissue
EP2962728B1 (en) * 2013-02-28 2019-01-16 Alpinion Medical Systems Co., Ltd. Ultrasonic medical apparatus for focal point compensation
US11464482B2 (en) 2013-03-04 2022-10-11 Sunnybrook Research Institute System and method for measuring and correcting ultrasound phase distortions induced by aberrating media
CN204637350U (zh) 2013-03-08 2015-09-16 奥赛拉公司 美学成像与处理系统、多焦点处理系统和执行美容过程的系统
US10561862B2 (en) 2013-03-15 2020-02-18 Guided Therapy Systems, Llc Ultrasound treatment device and methods of use
US9667889B2 (en) 2013-04-03 2017-05-30 Butterfly Network, Inc. Portable electronic devices with integrated imaging capabilities
JP6600304B2 (ja) 2013-07-03 2019-10-30 ヒストソニックス，インコーポレーテッド 衝撃散乱を使用した気泡雲形成のために最適化されたヒストトリプシ励起シーケンス
US11432900B2 (en) 2013-07-03 2022-09-06 Histosonics, Inc. Articulating arm limiter for cavitational ultrasound therapy system
WO2015027164A1 (en) 2013-08-22 2015-02-26 The Regents Of The University Of Michigan Histotripsy using very short ultrasound pulses
US10631914B2 (en) 2013-09-30 2020-04-28 Covidien Lp Bipolar electrosurgical instrument with movable electrode and related systems and methods
US10314647B2 (en) 2013-12-23 2019-06-11 Medtronic Advanced Energy Llc Electrosurgical cutting instrument
US10813686B2 (en) 2014-02-26 2020-10-27 Medtronic Advanced Energy Llc Electrosurgical cutting instrument
US9492121B2 (en) 2014-03-18 2016-11-15 Monteris Medical Corporation Image-guided therapy of a tissue
WO2015143026A1 (en) 2014-03-18 2015-09-24 Monteris Medical Corporation Image-guided therapy of a tissue
US10675113B2 (en) 2014-03-18 2020-06-09 Monteris Medical Corporation Automated therapy of a three-dimensional tissue region
SG11201608691YA (en) 2014-04-18 2016-11-29 Ulthera Inc Band transducer ultrasound therapy
CN103990233B (zh) * 2014-05-22 2017-02-01 天津医科大学 高强度超声经颅聚焦的相控方法
US9974599B2 (en) 2014-08-15 2018-05-22 Medtronic Ps Medical, Inc. Multipurpose electrosurgical device
US10535332B2 (en) * 2014-09-05 2020-01-14 University Of Washington Confinement or movement of an object using focused ultrasound waves to generate an ultrasound intensity well
US9956029B2 (en) 2014-10-31 2018-05-01 Medtronic Advanced Energy Llc Telescoping device with saline irrigation line
WO2016084220A1 (ja) * 2014-11-28 2016-06-02 キヤノン株式会社 超音波プローブ、及びそれを備えた情報取得装置
US10188456B2 (en) 2015-02-18 2019-01-29 Medtronic Xomed, Inc. Electrode assembly for RF energy enabled tissue debridement device
US10376302B2 (en) 2015-02-18 2019-08-13 Medtronic Xomed, Inc. Rotating electrical connector for RF energy enabled tissue debridement device
US11207130B2 (en) 2015-02-18 2021-12-28 Medtronic Xomed, Inc. RF energy enabled tissue debridement device
US11179581B2 (en) 2015-03-09 2021-11-23 The Research Foundation For The State University Of New York Systems and methods for promoting cellular activities for tissue maintenance, repair, and regeneration
US10327830B2 (en) 2015-04-01 2019-06-25 Monteris Medical Corporation Cryotherapy, thermal therapy, temperature modulation therapy, and probe apparatus therefor
JP6979882B2 (ja) 2015-06-24 2021-12-15 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン 脳組織の治療のための組織破砕療法システムおよび方法
US11389227B2 (en) 2015-08-20 2022-07-19 Medtronic Advanced Energy Llc Electrosurgical device with multivariate control
US11051875B2 (en) 2015-08-24 2021-07-06 Medtronic Advanced Energy Llc Multipurpose electrosurgical device
KR102615327B1 (ko) 2016-01-18 2023-12-18 얼테라, 인크 환형 초음파 어레이가 가요성 인쇄 회로 기판에 지엽적으로 전기적으로 연결된 컴팩트한 초음파 디바이스 및 그 조립 방법
KR102593310B1 (ko) 2016-08-16 2023-10-25 얼테라, 인크 이미징 오정렬을 감소시키도록 구성된 초음파 이미징 시스템, 초음파 이미징 모듈 및 이미징 오정렬을 감소시키는 방법
JP7237829B2 (ja) 2016-11-11 2023-03-13 ガイネソニックス， インコーポレイテッド 組織の制御された治療と組織および／または治療データとの動的相互作用およびそれらの比較
US11103731B2 (en) * 2017-01-12 2021-08-31 Insightec, Ltd. Overcoming acoustic field and skull non-uniformities
US10194975B1 (en) 2017-07-11 2019-02-05 Medtronic Advanced Energy, Llc Illuminated and isolated electrosurgical apparatus
CN109125960B (zh) * 2017-08-31 2020-11-10 上海沈德医疗器械科技有限公司 一种在空间指定位置上形成多种聚焦超声焦点的设备
US11020188B2 (en) 2017-11-10 2021-06-01 Sigma Instruments Holdings, Llc System, method, and GUI for treating skin and underlying tissues for improved health, function and/or appearance
US11944849B2 (en) 2018-02-20 2024-04-02 Ulthera, Inc. Systems and methods for combined cosmetic treatment of cellulite with ultrasound
US11813484B2 (en) 2018-11-28 2023-11-14 Histosonics, Inc. Histotripsy systems and methods
US11684807B2 (en) * 2018-12-27 2023-06-27 Insightec Ltd. Optimization of transducer configurations in ultrasound procedures
EP4096782A4 (en) 2020-01-28 2024-02-14 Univ Michigan Regents SYSTEMS AND METHODS FOR IMMUNOSENSITIZATION BY HISTOTRIPSY
ES2811092B2 (es) * 2020-07-20 2021-04-22 Univ Valencia Politecnica Sistema de fragmentacion controlada de solidos mediante haces acusticos de vortice
CN113349881A (zh) * 2021-05-28 2021-09-07 西安交通大学 上百阵元相控阵脉冲超声多焦点组织毁损控制方法和系统
US11524183B1 (en) 2022-03-11 2022-12-13 Sonablate Corp. System, apparatus, and method for delivering ultrasound

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2079058U (zh) * 1990-12-21 1991-06-19 湖南中医学院 超声治疗仪用可调焦超声辐射器
US5526814A (en) * 1993-11-09 1996-06-18 General Electric Company Automatically positioned focussed energy system guided by medical imaging
US5558623A (en) * 1995-03-29 1996-09-24 Rich-Mar Corporation Therapeutic ultrasonic device
US5601086A (en) * 1995-05-12 1997-02-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Beat frequency ultrasonic microsphere contrast agent detection system
US5694936A (en) * 1994-09-17 1997-12-09 Kabushiki Kaisha Toshiba Ultrasonic apparatus for thermotherapy with variable frequency for suppressing cavitation
CN2362520Y (zh) * 1999-03-09 2000-02-09 北京贝仪医疗设备厂 高能超声体外聚焦热疗机功率超声发射器

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068961A3 (fr) 1981-06-26 1983-02-02 Thomson-Csf Dispositif d'échauffement localisé de tissus biologiques
US4441486A (en) 1981-10-27 1984-04-10 Board Of Trustees Of Leland Stanford Jr. University Hyperthermia system
DE3319871A1 (de) 1983-06-01 1984-12-06 Richard Wolf Gmbh, 7134 Knittlingen Piezoelektrischer wandler zur zerstoerung von konkrementen im koerperinnern
US4549533A (en) 1984-01-30 1985-10-29 University Of Illinois Apparatus and method for generating and directing ultrasound
US4865042A (en) 1985-08-16 1989-09-12 Hitachi, Ltd. Ultrasonic irradiation system
DE3732131A1 (de) 1987-09-24 1989-04-06 Wolf Gmbh Richard Fokussierender ultraschallwandler
US4955366A (en) * 1987-11-27 1990-09-11 Olympus Optical Co., Ltd. Ultrasonic therapeutical apparatus
US5291890A (en) 1991-08-29 1994-03-08 General Electric Company Magnetic resonance surgery using heat waves produced with focussed ultrasound
US5230334A (en) * 1992-01-22 1993-07-27 Summit Technology, Inc. Method and apparatus for generating localized hyperthermia
US5247935A (en) 1992-03-19 1993-09-28 General Electric Company Magnetic resonance guided focussed ultrasound surgery
WO1993019705A1 (en) * 1992-03-31 1993-10-14 Massachusetts Institute Of Technology Apparatus and method for acoustic heat generation and hyperthermia
DE4213586C2 (de) * 1992-04-24 1995-01-19 Siemens Ag Therapieeinrichtung zur Behandlung mit fokussierten akustischen Wellen
US5275165A (en) 1992-11-06 1994-01-04 General Electric Company Magnetic resonance guided ultrasound therapy system with inclined track to move transducers in a small vertical space
US5573497A (en) 1994-11-30 1996-11-12 Technomed Medical Systems And Institut National High-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes
DE4302538C1 (de) * 1993-01-29 1994-04-07 Siemens Ag Therapiegerät zur Ortung und Behandlung einer im Körper eines Lebewesens befindlichen Zone mit akustischen Wellen
US5307812A (en) 1993-03-26 1994-05-03 General Electric Company Heat surgery system monitored by real-time magnetic resonance profiling
US5368031A (en) 1993-08-29 1994-11-29 General Electric Company Magnetic resonance surgery using heat waves produced with a laser fiber
US5368032A (en) 1993-11-09 1994-11-29 General Electric Company Manually positioned focussed energy system guided by medical imaging
FR2715313B1 (fr) 1994-01-27 1996-05-31 Edap Int Procédé de commande d'un appareil de traitement par hyperthermie à l'aide d'ultrasons.
US5507790A (en) 1994-03-21 1996-04-16 Weiss; William V. Method of non-invasive reduction of human site-specific subcutaneous fat tissue deposits by accelerated lipolysis metabolism
US5443068A (en) 1994-09-26 1995-08-22 General Electric Company Mechanical positioner for magnetic resonance guided ultrasound therapy
US5490840A (en) 1994-09-26 1996-02-13 General Electric Company Targeted thermal release of drug-polymer conjugates
US5520188A (en) 1994-11-02 1996-05-28 Focus Surgery Inc. Annular array transducer
DE69634714T2 (de) * 1995-03-31 2006-01-19 Kabushiki Kaisha Toshiba, Kawasaki Therapeutisches Ultraschallgerät
US5711300A (en) 1995-08-16 1998-01-27 General Electric Company Real time in vivo measurement of temperature changes with NMR imaging
US5590657A (en) 1995-11-06 1997-01-07 The Regents Of The University Of Michigan Phased array ultrasound system and method for cardiac ablation
DE19635593C1 (de) * 1996-09-02 1998-04-23 Siemens Ag Ultraschallwandler für den diagnostischen und therapeutischen Einsatz
US5769790A (en) 1996-10-25 1998-06-23 General Electric Company Focused ultrasound surgery system guided by ultrasound imaging
US5873845A (en) 1997-03-17 1999-02-23 General Electric Company Ultrasound transducer with focused ultrasound refraction plate
IL123311A0 (en) * 1998-02-15 1998-09-24 Diasonics Israel Ltd Multi-frequency ultrasonic imaging and therapy
US6042556A (en) * 1998-09-04 2000-03-28 University Of Washington Method for determining phase advancement of transducer elements in high intensity focused ultrasound

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2079058U (zh) * 1990-12-21 1991-06-19 湖南中医学院 超声治疗仪用可调焦超声辐射器
US5526814A (en) * 1993-11-09 1996-06-18 General Electric Company Automatically positioned focussed energy system guided by medical imaging
US5694936A (en) * 1994-09-17 1997-12-09 Kabushiki Kaisha Toshiba Ultrasonic apparatus for thermotherapy with variable frequency for suppressing cavitation
US5558623A (en) * 1995-03-29 1996-09-24 Rich-Mar Corporation Therapeutic ultrasonic device
US5601086A (en) * 1995-05-12 1997-02-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Beat frequency ultrasonic microsphere contrast agent detection system
CN2362520Y (zh) * 1999-03-09 2000-02-09 北京贝仪医疗设备厂 高能超声体外聚焦热疗机功率超声发射器

Also Published As

Publication number Publication date
EP1274348A4 (en) 2005-03-23
CN1449261A (zh) 2003-10-15
EP1274348B1 (en) 2007-09-26
EP1274348B8 (en) 2007-11-21
US6419648B1 (en) 2002-07-16
DE60130642T2 (de) 2008-11-06
WO2001080708A3 (en) 2002-03-14
DE60130642D1 (de) 2007-11-08
ATE373988T1 (de) 2007-10-15
WO2001080708A2 (en) 2001-11-01
EP1274348A2 (en) 2003-01-15
AU2001250617A1 (en) 2001-11-07
JP2004511268A (ja) 2004-04-15

Similar Documents

Publication Publication Date Title
CN1294881C (zh) 减少相控阵聚焦超声系统中的次热点的系统
CN100415318C (zh) 利用聚焦超声对病人靶组织区域进行治疗性操作的系统
US6506171B1 (en) System and methods for controlling distribution of acoustic energy around a focal point using a focused ultrasound system
US6613005B1 (en) Systems and methods for steering a focused ultrasound array
US7806839B2 (en) System and method for ultrasound therapy using grating lobes
US8409099B2 (en) Focused ultrasound system for surrounding a body tissue mass and treatment method
US6506154B1 (en) Systems and methods for controlling a phased array focused ultrasound system
US8162858B2 (en) Ultrasonic medical treatment device with variable focal zone
JP3386488B2 (ja) 超音波治療装置
JP5248491B2 (ja) シーケンス機能を有する治療装置
WO2003097162A2 (en) Enhanced focused ultrasound ablation using microbubbles
CN204601410U (zh) 多频环阵探头及包含其的超声理疗仪
WO1999049788A9 (en) Ablation system
KR101935375B1 (ko) Ｈｉｆｕ와 초음파 영상을 위한 초음파 치료 장치 및 그 제어 방법
CN1798591A (zh) 具有中心开口的超声探测器
JP3644644B2 (ja) 超音波治療装置
JP2000254139A (ja) 超音波治療装置
Song et al. A 1372‐element Large Scale Hemispherical Ultrasound Phased Array Transducer for Noninvasive Transcranial Therapy
JPH0712362B2 (ja) 超音波治療装置
Frizzell et al. Sparse random ultrasound array for focal surgery
Song et al. Electronically steerable large-scale ultrasound phased-array for noninvasive transcranial therapy
JPH09234205A (ja) 衝撃波治療装置
Fjield et al. Method of reduction of the number of driving system channels for phased-array transducers using isolation transformers

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
C56 Change in the name or address of the patentee

Owner name: INSIGHTEC IMAGE GUIDED TREAT L

Free format text: FORMER NAME: INSIGHTEC TXSONICS LTD

CP01 Change in the name or title of a patent holder

Address after: Israel, Mount Carmel

Patentee after: INSIGHTEC, Ltd.

Address before: Israel, Mount Carmel

Patentee before: Tektronix Yinsai - image guided treatment Co.

CP03 Change of name, title or address

Address after: Israel, Mount Carmel

Patentee after: INSIGHTEC-TXSONICS Ltd.

Address before: Israel Carle, tirat Kazakhstan

Patentee before: Txsonics Ltd.

TR01 Transfer of patent right

Effective date of registration: 20100527

Address after: Israel, Mount Carmel

Patentee after: Tektronix Yinsai - image guided treatment Co.

Address before: Israel, Mount Carmel

Patentee before: INSIGHTEC-TXSONICS Ltd.

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20070117