CN1314384C - Oral cavity nursing agent - Google Patents
Oral cavity nursing agent Download PDFInfo
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- CN1314384C CN1314384C CNB2004100523087A CN200410052308A CN1314384C CN 1314384 C CN1314384 C CN 1314384C CN B2004100523087 A CNB2004100523087 A CN B2004100523087A CN 200410052308 A CN200410052308 A CN 200410052308A CN 1314384 C CN1314384 C CN 1314384C
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Abstract
The present invention relates to a preparation product for dentistry, particularly to mouth cavity nursing agent which contains quaternary ammonium salt, biguanide, non-ionic surfactant, aluminum and zinc polybasic acid compound, hydrophilic solvent, enzyme inhibitor and water, the formula of the present invent comprises the following procedures that the aluminum and zinc polybasic acid compound adopts the way that polybasic acid is dissolved in the water and is stirred, alkaline inorganic zinc and alkaline inorganic aluminum are added in the mixture of the polybasic acid and the water until the alkaline inorganic zinc and the alkaline inorganic aluminum are completely dissolved, then, the mixture is blended with ammonia water or sodium hydroxide or potassium hydroxide to have a pH vale of 7.0 and is distilled to remove solvent. Because the mouth cavity nursing agent of the present invention adopts the way that zinc ions and aluminum ions are compounded with polybasic acid so as to reduce the irritation and the astringency to a mouth cavity, which are resulted from zinc ions and aluminum ions, and add the comfortable feeling of a mouth cavity.
Description
Technical field:
The present invention relates to the oral hygiene field, specifically relate to dental preparation, particularly a kind of oral cavity nursing agent.
Background technology:
The purpose of mouth care at first is cleaning oral cavity, keep oral hygiene, prevention of oral infections; Next is to prevent halitosis, the normal abnormal smells from the patient in maintenance oral cavity; Be to prevent that tartar from forming once more, keep the generation of tooth brilliant white health, prophylaxis of teeth disease; Provide the pleasant abnormal smells from the patient in oral cavity at last, keep the oral cavity moistening.Wherein important is to suppress, remove halitosis and tartar.
Halitosis is relevant with the ecological environment in oral disease and oral cavity.The oral cavity is unclean, dental calculus, tartar, oral cavity Organic substance decompose is to cause the most direct reason of halitosis.Oral cavity commonly used deodorizing method has following several: the first, use masking agent to cover oral cavity smell.As use essence or other irritative gass to cover; The second, reduce the content of irritative gas with chemical reaction method, as use gas reaction in unsaturated aldehyde ketone and the oral cavity; Three, use biological preparation to suppress the oral cavity organic matter degradation, suppress biological enzyme activity as using enzyme inhibitors such as sodium citrate; Four, use the disinfection active component, suppress the oral microorganism activity.
Tartar is the yellow or white organic substance complex of antibacterial, epidermis cell, leukocyte and other oral secretions.Contain 400 kinds of different bacterium in the tartar, antibacterial accounts for 3/4ths of tartar.Tartar is the main cause that odontopathy produces.Anticalculous method commonly used has two kinds, and a kind of antimicrobial acivity composition that is to use stops the breeding of antibacterial in the oral cavity as antibacterial and antibacterial, suppresses the biological activity of antibacterial in the oral cavity; Another kind is to use Zinc compounds or aluminide.
In oral cavity nursing agent, use disinfectant to suppress the oral microorganism physiologically active, mainly suppress and remove abnormal flavour in the oral cavity, can partly suppress and remove denude simultaneously.The disinfectant that uses in the oral cavity nursing agent mainly is a cationic substance, as quaternary amine and biguanide.US4,183,916 patents are mentioned and are used biguanide and quaternary amine to prevent that tartar from producing.At US 4,188, mention in 372 patents and use quaternary amine as the disinfection active component.But two patents are not mentioned compound use aluminide and Zinc compounds, have the following disadvantages: at first quaternary amine of Shi Yonging and biguanide concentration height, the oral cavity zest is increased, and influence the saliva of buccal cavity secretory function.Secondly, to suppressing and to remove the denude effect little.
Zinc compounds and aluminide have good effect for generation that reduces tartar and inhibition oral cavity smell.Wherein Zinc compounds also has good effect for the treatment dental disorder.US4,138,477 mention that Zinc compounds can reduce oral cavity smell, prevent that tartar from producing.U.S 4,937, and 066 mentions that zinc derivative forms and reduces halitosis at the minimizing tartar and has good result.But all not mentioned compound use aluminide of two patents.US5,028,412 patent anti-calculus oral cavity nursing agent contains water-soluble aluminum salt.US 6,277, and 359 patents use aluminium chlorohydrate as the deodorant activities composition.But all not mentioned compound use Zinc compounds of two patents.Employed Zinc compounds of above-mentioned US patent and aluminide have good water-solubility, and the oral cavity is had strong impulse and convergence, suppress salivation in the oral cavity, influence the oral cavity normal function.In order to reduce the zest and the convergence of zinc salt and aluminum salt, US 4,937, and 066 patent has proposed a kind of improvement project, use water solublity weak zinc salt or aluminum salt, as zinc tartrate sodium and zinc tartrate ammonium.US6,303,111 patents use aluminium citrate all to obtain good result as the deodorant activities composition.Though the salt of weak acid of use aluminum or the salt of weak acid of zinc reduce the side effect in oral cavity, the aluminum in the oral cavity or the valid density of zinc reduce, and have influenced effect of drugs.Attempt to improve effect of drugs so dig the person of making, yet but suppress salivation in the oral cavity equally, influence the oral cavity normal function by escalated dose.
Summary of the invention:
Technical problem solved by the invention is to reduce the zest and the convergence in zinc salt and aluminum salt pair oral cavity, a kind of chemically stable cleaning oral cavity is provided, suppresses halitosis, prevents the oral cavity nursing agent of tartar.
The technical solution that the present invention solves the problems of the technologies described above is as described below:
A kind of oral cavity nursing agent, contain following component by weight percentage:
(a) quaternary ammonium salt 0.001～1.0%;
(b) biguanide 0.001～1.0%;
(c) non-ionic surface active agent 0.05～8%;
(d) zinc-aluminium polyprotic acid complex 0.05～5%;
(e) hydrophilic solvent 20～25%;
(f) enzyme inhibitor 0.1～1.5%;
(g) surplus is a water.
The quaternary amine that the present invention mentions can be the alkyl pyridine ammonium halide.Wherein alkyl is C8～18 straight or branched alkyl, preferably straight chained alkyls.Quaternary amine commonly used is wherein one or more mixture of dodecylpyridine chloride ammonium, myristyl pyridine chlorination ammonium, cetyl pyridinium ammonium chloride, dodecyl pyridine ammonium bromide, myristyl pyridine ammonium bromide, cetyl pyridinium ammonium bromide.
The quaternary amine that the present invention mentions can be the dialkyl monohalide Dimethyl Ammonium, and one of them alkyl is C8～18 straight or branched alkyl, straight chained alkyl preferably, and another alkyl is the phenol oxyalkyl or the ethoxy alkyl of C1～4.Quaternary amine commonly used is wherein one or more mixture of chlorination dodecyl dimethyl (2-benzene oxygen ethyl) ammonium, bromination dodecyl dimethyl (2-benzene oxygen ethyl) ammonium, chlorination dodecyl dimethyl (2-ethoxyethyl) ammonium, bromination dodecyl dimethyl (2-ethoxyethyl) ammonium.
The quaternary amine that the present invention mentions can be a halogenation dimethyl alkyl benzyl ammonium.Wherein alkyl is aliphatic or aromatic series alkyl, the preferably aliphatic alkyl of C6～22.Alkyl can be straight or branched, preferably straight chain.Quaternary amine commonly used is wherein one or more mixture of dodecyl dimethyl benzyl ammonium chloride, chlorination myristyl dimethyl benzyl ammonium, cetalkonium chloride, octadecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl benzyl ammonium bromide, bromination myristyl dimethyl benzyl ammonium, bromination hexadecyldimethyl benzyl ammonium hexadecyldimethyl benzyl ammonium, bromination octadecyl dimethyl benzyl ammonium.
The quaternary amine that the present invention mentions is octadecyl dimethyl benzyl ammonium chloride, TPC, cetylpyridinium chloride, chlorination dodecyl dimethyl (2-phenol ethyl) ammonium one or more mixture wherein preferably.
Quaternary ammonium salt consumption among the present invention better is 0.01～0.2% (weight), preferably 0.03～0.1% (weight).
The biguanide that the present invention mentions is 1,6-two (2-ethylhexyl biguanide) hexane dihydrochloride, 1,6-two (2-ethylhexyl biguanide) octane dihydrochloride, 1,6-two (2-ethylhexyl biguanide) nonane dihydrochloride, 1,6-two (2-ethylhexyl biguanide) dodecane dihydrochloride, 1,6-two (4-chlorphenyl biguanide) hexane dihydrochloride and diacetate thereof, digluconate be one or more mixture wherein.Preferably 1,6-two (4-chlorphenyl biguanide) hexane dihydrochloride, 1,6-two (4-chlorphenyl biguanide) hexane diacetate and 1,6-two (4-chlorphenyl biguanide) hexane two Fructus Vitis viniferae hydrochlorates are one or more mixture wherein.
The biguanide consumption that the present invention mentions is 0.01～0.08% (weight) preferably.
Quaternary ammonium salt that the present invention mentions and biguanide consumption proportion are 5: 1～1: 5, better are 2: 1～1: 2, preferably 1: 1.
The non-ionic surface active agent that the present invention mentions comprises polyol ester, alkylolamides, alkyl polydextrose, ethylene oxide adduct and amine oxide.Preferably ethylene oxide adduct, amine oxide.Amine oxide has dimethyl dodecyl amine oxide, CH3-(CH2)13N(CH3)2-O, dimethyl cocoa alkyl amine oxide, dimethyl hydrogen carburetion base amine oxide, dicyclo (2-ethoxy) cocoa amine oxide, two (2-ethoxy) oil base amine oxide.Non-ionic surface active agent commonly used is wherein one or more mixture of Nonyl pheno (OP-10), octyl phenol polyoxy ethylene, polyoxyethylene sorbitan monooleate dehydration (tween-80), decyl dimethyl oxidation amine, lauryl dimethyl amine oxide, octyldimethyl amine oxide, myristyl dimethyl amine oxide.
The non-ionic surface active agent consumption that the present invention mentions is 0.5～4.0% (weight) preferably.
The zinc-aluminium polyprotic acid complex that the present invention mentions is the polynary hydrochlorate of zinc and aluminum, has structure M
aAl
bZn
cB
d, wherein M is potassium ion or sodium ion or ammonium ion; B is binary or ternary organic acid; C: b is 4: 1～1: 1, is preferably 2: 1～1: 1, preferably 1.5: 1; (b+c): d is 1: 1.3～1: 2, preferably 1: 1.5.Be 0 calculating a wherein according to zinc-aluminium polyprotic acid complex molecule total electrical charge.
The organic multicomponent acid that the present invention mentions is commonly used to be wherein one or more mixture of citric acid, tartaric acid, malic acid, glyceric acid, ethanedioic acid, succinic acid, maleic acid, Fumaric acid, malonic acid, Isosuccinic acid, dimethyl malonic acid, carboxyl malonic acid.Organic multicomponent acid of the present invention, preferably citric acid, malic acid, tartaric acid, succinic acid, maleic acid one or more mixture wherein.
The zinc-aluminium polyprotic acid complex that the present invention mentions is M
21Al
4Zn
6B
15, wherein M is potassium ion or sodium ion or ammonium ion; B is a citric acid.
The zinc-aluminium polyprotic acid complex that the present invention mentions is M
6Al
4Zn
6B
15, wherein M is potassium ion or sodium ion or ammonium ion; B is wherein one or more mixture of tartaric acid, malic acid, succinic acid, maleic acid.
Zinc-aluminium polyprotic acid complex can prepare in order to the below method: with polyprotic acid, alkaline inorganic zinc and alkaline inorganic aluminum mix homogeneously in water, adjust pH value of solution, drying is removed to desolvate and is obtained product.Below be the preparation method of using always: at first polyprotic acid is dissolved in the water, stirring adds alkaline inorganic zinc and alkaline inorganic aluminum, dissolve fully until alkaline inorganic zinc and alkaline inorganic aluminum, transferring pH with ammonia or sodium hydroxide or potassium hydroxide then is 7.0, and distillation removes to desolvate and obtains product.
The alkaline inorganic zinc that the present invention mentions is meant wherein one or more chemical compounds of zinc oxide, zinc hydroxide, zinc carbonate.The inorganic aluminum of alkalescence is meant wherein one or more chemical compounds of aluminium oxide, aluminium hydroxide, aluminium carbonate.
The zinc-aluminium polyprotic acid complex consumption that the present invention mentions better is 0.1～3% (weight), preferably 0.5～1.5% (weight).
The hydrophilic solvent that the present invention mentions act as stable and dissolving disinfectant component, and bactericidal action is provided.Hydrophilic solvent has C1～4 low-carbon alcohols, as methanol, ethanol, propanol, isopropyl alcohol, butanols, isobutanol.Hydrophilic solvent can also be C1～4 dihydroxylic alcohols, as ethylene glycol, propylene glycol, 1, ammediol.Hydrophilic solvent can also be phenyl phenol, 1-phenoxypropanol, the 2-phenoxypropanol.Hydrophilic solvent can be one or more mixture of above-mentioned alcohol.
The enzyme inhibitor that the present invention mentions act as the activity that suppresses biodegradable enzyme, reduces the Degradation of microorganism.Enzyme inhibitor commonly used is wherein one or more mixture of trimethyl citrate, citric acid tripropyl ester, citric acid tributyl ester, triethyl citrate, 1,3-propanedicarboxylic acid mono ethyl ester, diethyl malate, monoethyl adipatee, ethyl maleate..
The enzyme inhibitor consumption that the present invention mentions is 0.5～1% (weight) preferably.
It is 5.0～8.0 that the present invention uses multicomponent organic acid to adjust pH, better is 6.0～6.5.Organic multicomponent acid is citric acid, maleic acid, malic acid, tartaric acid, succinic acid one or more mixture wherein preferably.
The present invention can also contain can select component, as viscosity modifier, quintessence oil, pigment, flavoring agent, sweeting agent, essence etc.Can select amounts of components to be no more than 10%.
Quintessence oil commonly used is wherein one or more mixture of Eucalyptus oil, menthol, cresotic acid, thymol.The quintessence oil consumption is 0.01 ~ 5% (weight).
Viscosity modifier commonly used is selected from wherein one or more mixture of sodium alginate, xanthan gum, hydroxyethyl-cellulose, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, PVP, guar gum, polyvinyl alcohol.The viscosity modifier consumption is 0.1%～5% (weight), is preferably 0.1%～1% (weight), is preferably 0.1%～0.5% (weight).
The preparation method of oral cavity nursing agent of the present invention can adopt mixed method preparation commonly used.Solid constituent is dissolved in water or the hydrophilic solvent, and mix homogeneously gets final product.Method commonly used is that water-soluble components such as quaternary amine, biguanide, zinc-aluminium polyprotic acid complex are dissolved in the water; Essence, enzyme inhibitor, quintessence oil etc. are dissolved in the hydrophilic solvent; With water and hydrophilic solvent mix homogeneously; Adjust pH value of solution, adjust solution viscosity with viscosity modifier.
The using method of oral cavity nursing agent of the present invention is oral cavity nursing agent using method commonly used.
Oral cavity nursing agent of the present invention uses cation disinfection active component such as quaternary amine and biguanide, the physiologically active that can suppress the microorganism such as various antibacterials, fungus in oral cavity and the tartar at short notice, suppress the formation of halitosis generation and tartar, safeguard oral hygiene; The present invention uses enzyme inhibitor, the metabolism of antibacterial and fungus in the inhibition oral cavity, the activity of inhibitory enzyme; The present invention uses non-ionic surface active agent, utilize cation disinfection active component and non-ionic surface active agent to increase the sterilization effect of cation sterilizing active component with benefit on the one hand, utilize the cleaning action of non-ionic surface active agent on the one hand, safeguard oral hygiene.
The present invention uses zinc-aluminium polyprotic acid complex, and zinc salt and aluminum salt binding are worked in coordination with use together, increases that two kinds of ion pair oral cavities are different hides and the inhibitory action of tartar.Simultaneously that zinc ion and aluminium ion and polyprotic acid is compound, thus reduce zinc ion and aluminium ion to the zest and the convergence in oral cavity, increase mouth comfort.
Sterilizing active component and oral cavity deodorant activities composition and human body affinity height that the present invention uses, toxicity is little, to the environment friendliness, so the present invention is to human body nonirritant, low, the non-environmental-pollution of toxicity.The present invention uses hydrophilic solvent, adopts liquid form, makes the present invention have advantage safe, simple to operate easy to use.
The sterilizing method for testing performance of oral cavity nursing agent of the present invention is according to " disinfection technology standard " standard method of measurement and the U.S. AOAC standard method of measurement detection of Ministry of Health of the People's Republic of China.
Oral cavity nursing agent physical stability measuring method of the present invention: with oral cavity nursing agent be placed on 25 ℃ following 12 hours, then oral cavity nursing agent is placed on-5 ℃ following 12 hours, be placed on after the taking-up 25 ℃ following 12 hours, be a circulation.After carrying out 5 circulations altogether, measure its viscosity, whether whether whether pH value changes, observe color and change, have precipitation, lamination to produce.
Oral cavity nursing agent high-temperature stable measuring method of the present invention, with oral cavity nursing agent be placed on 50 ℃ following 48 hours, at first observe viscosity, whether color changes, observe phenomenons such as whether producing precipitated and separated; Whether measure pH and change, " disinfection technology standard " detection method according to Ministry of Health of the People's Republic of China detects antiseptic property then.
The oral stimulation measuring method: at first gargle with clear water, tranquillization 5-10 minute, discard the saliva of initial secretions, collect and continue excretory saliva 2ml, calculate acquisition time.Draw the 4ml oral cavity nursing agent then and in the oral cavity, kept 1 minute, tell then.Collect the excretory saliva 2ml in oral cavity after 1 hour, calculate acquisition time.Measure and use lactobacillus content and pH value in the saliva of collecting before and after the oral cavity nursing agent.Estimate the influence of oral cavity nursing agent to lactobacillus amount in salivation amount, pH, the saliva.
The specific embodiment:
It below is the non-limiting example of technical scheme of the present invention.
Embodiment 1
Zinc-aluminium citric acid complex preparation method: the 1.0mol citric acid is dissolved in the suitable quantity of water, stirs adding 0.05mol aluminium oxide and 0.4mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Use potassium hydroxide
Transferring pH is 7.0.Remove and anhydrate, crystallization obtains 290g zinc-aluminium citric acid complex K
19AlZn
4(C
6H
5O
7)
10
Described oral cavity nursing agent is composed of the following components by weight percentage:
Chlorination octadecyl dimethylbenzyl ammonium 1.0%
1,6-two (4-chlorphenyl biguanide) hexane dihydrochloride 1.0%
Nonyl pheno (OP-10) 10%
Zinc-aluminium citric acid complex K
19AlZn
4(C
6H
5O
7)
101.5%
Ethanol 35%
Trimethyl citrate 1.5%
Water adds to 100%
PH is adjusted into 6.5.
Method beyond above-mentioned and step are implemented to get final product with reference to prior art.
According to " disinfection technology standard " measuring method to the embodiment 1 described oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.5, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.5, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 1.
Table 1
| Average salivation amount (ml/min) | pH | The lactobacillus amount | |
| Before the use | 0.72 | 6.7 | 5320 |
| After the use | 0.75 | 6.6 | 821 |
Embodiment 2
Zinc-aluminium tartaric acid complex preparation method: 0.65mol tartaric acid is dissolved in the suitable quantity of water, stirs adding 0.05mol aluminium carbonate and 0.4mol zinc carbonate, dissolve fully until aluminium carbonate and zinc carbonate.Transferring pH with sodium hydroxide is 7.0.Remove and anhydrate, crystallization obtains 128g zinc-aluminium tartaric acid complex Na
2AlZn
4(C
4H
4O
6)
6.5
Described oral cavity nursing agent is composed of the following components by weight percentage:
Myristyl pyridine chlorination ammonium 0.001%
1,6-two (4-chlorphenyl biguanide) hexane diacetate 0.001%
Octyl phenol polyoxy ethylene (OP-10) 0.05%
Zinc-aluminium tartaric acid complex Na
2AlZn
4(C
4H
4O
6)
6.50.05%
Butanols 5%
Citric acid three propyl ester 0.1%
Water adds to 100%
PH is adjusted into 5.5.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the embodiment 2 described oral cavity nursing agents effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 5.5, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 5.5, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 2.
Table 2
| Average salivation amount (ml/min) | pH | The lactobacillus amount | |
| Before the use | 0.83 | 5.6 | 6538 |
| After the use | 0.79 | 5.3 | 2845 |
Embodiment 3
Zinc-aluminium citric acid complex preparation method: the 0.65mol citric acid is dissolved in the suitable quantity of water, stirs adding 0.05mol aluminium carbonate and 0.4mol zinc oxide, dissolve fully until aluminium carbonate and zinc oxide.Transferring pH with potassium hydroxide is 7.0.Remove and anhydrate, crystallization obtains 183g zinc-aluminium citric acid complex K
8.5AlZn
4(C
6H
5O
7)
6.5
Zinc-aluminium citric acid complex preparation method: the 0.4mol citric acid is dissolved in the suitable quantity of water, stirs adding 0.1mol aluminium hydroxide and 0.1mol zinc oxide, dissolve fully until aluminium hydroxide and zinc oxide.Transferring pH with sodium hydroxide is 7.0.Remove and anhydrate, crystallisation by cooling obtains 100g zinc-aluminium citric acid complex Na
7AlZn (C
6H
5O
7)
4
Described oral cavity nursing agent is composed of the following components by weight percentage:
Chlorination dodecyl dimethyl (2-benzene oxygen ethyl) ammonium 0.05%
Dodecyl dimethyl benzyl ammonium chloride 0.05%
1,6-two (2-ethylhexyl biguanide) octane dihydrochloride 0.03%
1,6-two (2-ethylhexyl biguanide) nonane dihydrochloride 0.04%
Myristyl dimethyl amine oxide 0.5%
Polyoxyethylene sorbitan monooleate dehydration 1.5
Zinc-aluminium citric acid complex K
8.5AlZn
4(C
6H
5O
7)
6.52%
Zinc-aluminium citric acid complex Na
7AlZn (C
6H
5O
7)
43%
Propanol 10%
Ethanol 25%
Tributyl citrate 0.5%
Trimethyl citrate 0.5%
Sodium alginate 0.4%
Water adds to 100%
PH is adjusted into 6.0.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the embodiment 3 described oral cavity nursing agents effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.1, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.0, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 3.
Table 3
| Average salivation amount (ml/min) | pH | The lactobacillus amount | |
| Before the use | 1.02 | 5.3 | 10320 |
| After the use | 0.95 | 5.0 | 5853 |
Embodiment 4
Zinc-aluminium maleic acid complex preparation method: the 0.4mol maleic acid is dissolved in the suitable quantity of water, stirs adding 0.05mol aluminium carbonate and 0.1mol zinc hydroxide, dissolve fully until aluminium carbonate and zinc hydroxide.Transferring pH with sodium hydroxide is 7.0.Remove and anhydrate, crystallization obtains 59g zinc-aluminium maleic acid complex Na
3AlZn (C
4H
2O
4)
4
Zinc-aluminium citric acid complex preparation method: the 0.6mol citric acid is dissolved in the suitable quantity of water, stirs adding 0.05mol aluminium oxide and 0.2mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with potassium hydroxide is 7.0.Remove and anhydrate, crystallisation by cooling obtains 170g zinc-aluminium citric acid complex K
11AlZn
2(C
6H
5O
7)
6
Described oral cavity nursing agent is composed of the following components by weight percentage:
Chlorination dodecyl dimethyl (2-ethoxyethyl) ammonium 0.005%
Bromination dodecyl dimethyl (2-benzene oxygen ethyl) ammonium 0.005%
1,6-two (2-ethylhexyl biguanide) dodecane dihydrochloride 0.01%
Decyl dimethyl oxidation amine 2.5%
Lauryl dimethyl amine oxide 1.5%
Zinc-aluminium citric acid complex K
11AlZn
2(C
6H
5O
7)
61.5%
Zinc-aluminium maleic acid complex Na
3AlZn (C
4H
2O
4)
42.5%
Isopropyl alcohol 10%
Ethanol 15%
Citric acid three propyl ester 0.4%
Trimethyl citrate 0.3%
Eucalyptus oil 2.5%
Hydroxyethyl-cellulose 0.3%
Water adds to 100%
PH is adjusted into 6.1.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.0, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 5.9, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 4.
Table 4
| Average salivation amount (ml/min) | pH | The lactobacillus amount | |
| Before the use | 0.98 | 5.8 | 4983 |
| After the use | 0.97 | 5.8 | 2510 |
Embodiment 5
Zinc-aluminium malic acid complex preparation method: the 0.39mol malic acid is dissolved in the suitable quantity of water, stirs adding 0.1mol aluminium oxide and 0.2mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with ammonia is 7.0.Remove and anhydrate, crystallization obtains 68g zinc-aluminium malic acid complex (NH
4)
0.8AlZn
2(C
4H
4O
5)
3.9
Described oral cavity nursing agent is composed of the following components by weight percentage:
Cetyl pyridinium ammonium chloride 0.2%
1,6-two (2-ethylhexyl biguanide) hexane dihydrochloride 0.08%
Nonyl pheno 4.0%
Zinc-aluminium malic acid complex (NH
4)
0.8AlZn
2(C
4H
4O
5)
3.910%
Propanol 30%
Tributyl citrate 1.0%
Carboxymethyl cellulose 0.2%
PVP 0.1％
Water adds to 100%
PH is adjusted into 6.2.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.2, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.2, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 5.
Table 5
| Average salivation amount (ml/min) | pH | The lactobacillus amount | |
| Before the use | 0.77 | 6.0 | 3206 |
| After the use | 0.75 | 5.9 | 1352 |
Embodiment 6
Zinc-aluminium citric acid complex preparation method: the 0.26mol citric acid is dissolved in the suitable quantity of water, stirs adding 0.05mol aluminium oxide and 0.1mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with potassium hydroxide is 7.0.Remove and anhydrate, crystallization obtains 68g zinc-aluminium citric acid complex K
2.8AlZn (C
6H
5O
7)
2.6
Described oral cavity nursing agent is composed of the following components by weight percentage:
Bromination dodecyl dimethyl (2-ethoxyethyl) ammonium 0.01%
Cetalkonium chloride 0.02%
1,6-two (2-ethylhexyl biguanide) dodecane dihydrochloride 0.3%
Lauryl dimethyl amine oxide 0.3%
Zinc-aluminium malic acid complex (NH
4)
0.8AlZn
2(C
4H
4O
5)
3.90.4%
Zinc-aluminium citric acid complex K
2.8AlZn (C
6H
5O
7) 2.6 0.1%
Phenyl phenol 5%
Ethanol 5%
Citric acid three propyl ester 0.2%
Trimethyl citrate 0.3%
Hydroxypropyl cellulose 0.5%
Water adds to 100%
PH is adjusted into 6.5.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.6, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes
Kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.4, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 6.
Table 6
| Average salivation amount (ml/min) | pH | The lactobacillus amount | |
| Before the use | 0.94 | 7.3 | 976 |
| After the use | 0.96 | 7.5 | 125 |
Embodiment 7
Zinc-aluminium tartaric acid complex preparation method: 0.6mol tartaric acid is dissolved in the suitable quantity of water, stirs adding 0.05mol aluminium carbonate and 0.2mol zinc carbonate, dissolve fully until aluminium carbonate and zinc carbonate.Transferring pH with sodium hydroxide is 7.0.Remove and anhydrate, crystallization obtains 113g zinc-aluminium tartaric acid complex Na
5AlZn
2(C
4H
4O
6)
6
Zinc-aluminium malic acid complex preparation method: the 1.5mol malic acid is dissolved in the suitable quantity of water, stirs adding 0.2mol aluminium oxide and 0.6mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with ammonia is 7.0.Remove and anhydrate, crystallization obtains 258g zinc-aluminium malic acid complex (NH
4)
6Al
4Zn
6(C
4H
4O
5)
15
Described oral cavity nursing agent is composed of the following components by weight percentage:
Dodecyl dimethyl benzyl ammonium bromide 0.02%
Cetalkonium chloride 0.05%
1,6-two (4-chlorphenyl biguanide) hexane dihydrochloride 0.02%
1,6-two (4-chlorphenyl biguanide) hexane diacetate 0.03%
Lauryl dimethyl amine oxide 1.0%
Zinc-aluminium malic acid complex (NH
4)
6Al
4Zn
6(C
4H
4O
5)
151%
Zinc-aluminium tartaric acid complex Na
5AlZn
2(C
4H
4O
6)
63%
Ethylene glycol 5%
Ethanol 10%
Citric acid three propyl ester 0.3%
Trimethyl citrate 0.6%
Carboxyethyl cellulose 0.1%
Polyvinyl alcohol 0.1%
Menthol 1.0%
Water adds to 100%
PH is adjusted into 6.8.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.8, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.8, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 7.
Table 7
| Average salivation amount (ml/min) | pH | The lactobacillus amount | |
| Before the use | 0.87 | 7.0 | 8642 |
| After the use | 0.88 | 6.8 | 3578 |
Embodiment 8
Zinc-aluminium tartaric acid complex preparation method: the 0.39mol citric acid is dissolved in the suitable quantity of water, stirs adding 0.05mol aluminium oxide and 0.2mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with potassium hydroxide is 7.0.Remove and anhydrate, crystallisation by cooling obtains 90g zinc-aluminium tartaric acid complex K
4.7AlZn
2(C
4H
4O
6)
3.9
Described oral cavity nursing agent is composed of the following components by weight percentage:
TPC 0.02%
Cetylpyridinium chloride 0.03%
1,6-two (4-chlorphenyl biguanide) hexane dihydrochloride 0.04%
Lauryl dimethyl amine oxide 1.5%
Polyoxyethylene sorbitan monooleate dehydration (tween-80) 1%
Zinc-aluminium tartaric acid complex K
4.7AlZn
2(C
4H
4O
6)
3.90.05%
Zinc-aluminium maleic acid complex Na
3AlZn (C
4H
2O
4)
40.05%
Propylene glycol 5%
Ethanol 15%
Trimethyl citrate 0.6%
Sodium alginate 1.0%
Thymol 2.5%
Menthol 2.5%
Glucide 0.1%
Water adds to 100%
PH is adjusted into 7.2.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 7.0, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 7.1, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
Embodiment 9
Zinc-aluminium citric acid complex preparation method: the 1.5mol citric acid is dissolved in the suitable quantity of water, stirs adding 0.2mol aluminium oxide and 0.6mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with potassium hydroxide is 7.0.Remove and anhydrate, crystallisation by cooling obtains 353g zinc-aluminium citric acid complex K
21Al
4Zn
6(C
6H
5O
7)
15
Zinc-aluminium succinic acid complex preparation method: the 0.26mol succinic acid is dissolved in the suitable quantity of water, stirs adding 0.05mol aluminium carbonate and 0.1mol zinc carbonate, dissolve fully until aluminium carbonate and zinc carbonate.Transferring pH with ammonia is 7.0.Remove and anhydrate, crystallization obtains 37g zinc-aluminium succinic acid complex (NH
4)
0.2AlZn (C
4H
4O
4)
2.6
Described oral cavity nursing agent is composed of the following components by weight percentage:
TPC 0.03%
Chlorination dodecyl dimethyl (2-phenol ethyl) ammonium 0.03%
1,6-two (4-chlorphenyl biguanide) hexane dihydrochloride 0.02%
Dimethylnonylamine oxide. 1.5%
Polyoxyethylene sorbitan monooleate dehydration (tween-80) 1.5%
Zinc-aluminium citric acid complex K
21Al
4Zn
6(C
6H
5O
7)
151%
Zinc-aluminium succinic acid complex (NH
4)
0.2AlZn (C
4H
4O
4)
2.61%
2-phenoxypropanol 5%
Ethanol 15%
Trimethyl citrate 0.6%
Hydroxypropyl cellulose 1.0%
Cresotic acid 1.0%
Glucide 0.1%
Water adds to 100%
PH is adjusted into 6.4.
According to " disinfection technology standard " measuring method to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.5, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.4, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out the oral stimulation measurement, result such as following table 8.
Table 8
| Component | Average salivation amount before and after using | PH before and after using | Lactobacillus amount before and after using |
| Embodiment 9 described oral cavity nursing agents | Constant | Constant | Reduce |
| 0.05% TPC aqueous solution | Constant | Increase | Reduce |
| 0.05% 1,6-two (4-chlorphenyl biguanide) hexane diacetate aqueous solution | Constant | Reduce | Reduce |
| 0.2% aluminum chloride aqueous solution | Reduce | Increase | Reduce |
| 0.2% solder(ing)acid | Reduce | Increase | Reduce |
Embodiment 10
Zinc-aluminium malic acid complex preparation method: the 1.5mol malic acid is dissolved in the suitable quantity of water, stirs adding 0.2mol aluminium oxide and 0.6mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with sodium hydroxide is 7.0.Remove and anhydrate, crystallisation by cooling obtains 353g zinc-aluminium malic acid complex Na
21Al
4Zn
6(C
6H
5O
7)
15
Zinc-aluminium citric acid complex preparation method: the 1.5mol citric acid is dissolved in the suitable quantity of water, stirs adding 0.2mol aluminium oxide and 0.6mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with ammonia is 7.0.Remove and anhydrate, crystallisation by cooling obtains 353g zinc-aluminium citric acid complex (NH
4)
21Al
4Zn
6(C
6H
5O
7)
15
Described oral cavity nursing agent is composed of the following components by weight percentage:
TPC 0.05%
1,6-two (4-chlorphenyl biguanide) hexane dihydrochloride 0.02%
Dimethylnonylamine oxide. 1.5%
Polyoxyethylene sorbitan monooleate dehydration (tween-80) 1.5%
Zinc-aluminium malic acid complex Na
21Al
4Zn
6(C
4H
4O
5)
151.5%
Zinc-aluminium citric acid complex (NH
4)
21Al
4Zn
6(C
6H
5O
7)
151%
1-propanol 5%
Ethanol 15%
Trimethyl citrate 0.6%
Hydroxyethyl-cellulose 0.7%
Xanthan gum 0.2%
Cresotic acid 1.0%
An amount of % of sweeting agent
Water adds to 100%
PH is adjusted into 6.3.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.3, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.5, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 9.
Table 9
| Component | Average salivation amount before and after using | PH before and after using | Lactobacillus amount before and after using |
| Embodiment 10 described oral cavity nursing agents | Constant | Constant | Reduce |
| 0.05% chlorination myristyl pyrrole water pyridine makes solution | Constant | Increase | Reduce |
| 0.05% 1,6-two (4-chlorphenyl biguanide) hexane diacetate aqueous solution | Constant | Increase | Reduce |
| 0.2% aluminum chloride aqueous solution | Reduce | Increase | Reduce |
| 0.2% solder(ing)acid | Reduce | Increase | Reduce |
Embodiment 11
Zinc-aluminium malic acid tartaric acid complex preparation method: 1.0mol malic acid and 0.5 tartaric acid are dissolved in the suitable quantity of water, stir adding 0.2mol aluminium oxide and 0.6mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with sodium hydroxide is 7.0.Removing anhydrates obtains 267g zinc-aluminium malic acid tartaric acid complex Na
6Al
4Zn
6(C
4H
4O
5)
10(C
4H
4O
6)
5
Zinc-aluminium malic acid maleic acid complex preparation method: 1.0mol malic acid and 0.5 maleic acid are dissolved in the suitable quantity of water, stir adding 0.2mol aluminium oxide and 0.6mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with sodium hydroxide is 7.0.Removing anhydrates obtains 250g zinc-aluminium malic acid maleic acid complex Na
6Al
4Zn
6(C
4H
4O
4)
10(C
4H
2O
4)
5
Described oral cavity nursing agent is composed of the following components by weight percentage:
TPC 0.03%
Chlorination octadecyl dimethylbenzyl ammonium 0.04%
1,6-two (4-chlorphenyl biguanide) hexane diacetate 0.07%
Dimethylnonylamine oxide. 2%
Lauryl dimethyl amine oxide 1.5%
Zinc-aluminium malic acid tartaric acid complex Na
6Al
4Zn
6(C
4H
4O
5)
10(C
4H
4O
6)
52%
Zinc-aluminium maleic acid succinic acid complex Na
6Al
4Zn
6(C
4H
4O
4)
10(C
4H
2O
4)
52%
1,3 propylene glycol 5%
Ethanol 15%
Trimethyl citrate 0.8%
Guar gum 0.5%
Methylcellulose 0.5%
Cresotic acid 0.5%
Thymol 0.5%
Glucide 0.1%
Pigment is an amount of
Essence is an amount of
Water adds to 100%
PH is adjusted into 6.0.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.1, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.1, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 10.
Table 10
| Component | Average salivation amount before and after using | PH before and after using | Lactobacillus amount before and after using |
| Embodiment 11 described oral cavity nursing agents | Constant | Constant | Reduce |
| 0.05% TPC aqueous solution | Constant | Increase | Reduce |
| 0.05% 1,6-two (4-chlorphenyl biguanide) hexane diacetate aqueous solution | Constant | Increase | Reduce |
| 0.2% aluminum chloride aqueous solution | Reduce | Increase | Reduce |
| 0.2% solder(ing)acid | Reduce | Increase | Reduce |
Embodiment 12
Zinc-aluminium malic acid tartaric acid complex preparation method: 0.5mol malic acid and 1.0 tartaric acid are dissolved in the suitable quantity of water, stir adding 0.2mol aluminium oxide and 0.6mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with sodium hydroxide is 7.0.Removing anhydrates obtains 267g zinc-aluminium malic acid tartaric acid complex Na
6Al
4Zn
6(C
4H
4O
5)
5(C
4H
4O
6)
10
Zinc-aluminium succinic acid tartaric acid complex preparation method: 1.0mol succinic acid and 0.5 tartaric acid are dissolved in the suitable quantity of water, stir adding 0.2mol aluminium oxide and 0.6mol zinc oxide, dissolve fully until aluminium oxide and zinc oxide.Transferring pH with sodium hydroxide is 7.0.Removing anhydrates obtains 251g zinc-aluminium succinic acid tartaric acid complex Na
6Al
4Zn
6(C
4H
4O
4)
10(C
4H
4O
6)
5
Described oral cavity nursing agent is composed of the following components by weight percentage:
TPC 0.03%
Chlorination octadecyl dimethylbenzyl ammonium 0.04%
1,6-two (4-chlorphenyl biguanide) hexane diacetate 0.07%
Dimethylnonylamine oxide. 2%
Lauryl dimethyl amine oxide 1.5%
Zinc-aluminium malic acid tartaric acid complex Na
6Al
4Zn
6(C
4H
4O
5)
5(C
4H
4O
6)
102%
Zinc-aluminium succinic acid tartaric acid complex Na
6Al
4Zn
6(C
4H
4O
4)
10(C
4H
4O
6)
52%
1,3 propylene glycol 5%
Ethanol 15%
Trimethyl citrate 0.8%
Guar gum 1.0%
Cresotic acid 0.5%
Thymol 0.5%
Glucide 0.1%
Pigment is an amount of
Essence is an amount of
Water adds to 100%
PH is adjusted into 6.3.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.3, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.3, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 11.
Table 11
| Component | Average salivation amount before and after using | PH before and after using | Lactobacillus amount before and after using |
| Embodiment 12 described oral cavity nursing agents | Constant | Constant | Reduce |
| 0.05% TPC aqueous solution | Constant | Increase | Reduce |
| 0.05% 1,6-two (4-chlorphenyl biguanide) hexane diacetate aqueous solution | Constant | Increase | Reduce |
| 0.2% aluminum chloride aqueous solution | Reduce | Increase | Reduce |
| 0.2% zinc nitrate aqueous solution | Reduce | Increase | Reduce |
Embodiment 13
Zinc-aluminium succinic acid maleic acid complex preparation method: 1.0mol succinic acid and 0.5 maleic acid are dissolved in the suitable quantity of water, stir adding 0.1mol aluminium carbonate, 0.1mol aluminium oxide, 0.4mol zinc oxide and 0.2mol zinc carbonate, dissolve fully until aluminium carbonate, aluminium oxide, zinc oxide and zinc oxide.Transferring pH with sodium hydroxide is 7.0.Removing anhydrates obtains 234g zinc-aluminium succinic acid maleic acid complex Na
6Al
4Zn
6(C
4H
4O
4)
10(C
4H
2O
4)
5
Described oral cavity nursing agent is composed of the following components by weight percentage:
TPC 0.03%
Chlorination octadecyl dimethylbenzyl ammonium 0.04%
1,6-two (4-chlorphenyl biguanide) hexane diacetate 0.07%
Dimethylnonylamine oxide. 2%
Lauryl dimethyl amine oxide 1.5%
Zinc-aluminium succinic acid maleic acid complex Na
6Al
4Zn
6(C
4H
4O
4)
10(C
4H
2O
4)
52%
Zinc-aluminium succinic acid tartaric acid complex Na
6Al
4Zn
6(C
4H
4O
4)
10(C
4H
4O
6)
52%
1,3 propylene glycol 5%
Ethanol 15%
Trimethyl citrate 0.8%
Guar gum 1.0%
Cresotic acid 0.5%
Thymol 0.5%
Glucide 0.1%
Pigment is an amount of
Essence is an amount of
Water adds to 100%
PH is adjusted into 6.5.
According to " disinfection technology standard " and U.S. AOAC standard method of measurement to the above-mentioned oral cavity nursing agent effect measuring that carries out disinfection.In 5 minutes, kill 99.9% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After 10 freezing-dissolving circulations, oral cavity nursing agent pH remains on 6.5, and no change color, no layering, deposited phenomenon produce.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
After the high-temperature stability detection, oral cavity nursing agent pH remains on 6.5, no change color, and no layering and precipitating phenomenon produces.According to " disinfection technology standard " effect measuring that carries out disinfection, in 5 minutes, kill 99% staphylococcus aureus, Staphylococcus albus, escherichia coli, Candida albicans.
The described oral cavity nursing agent of present embodiment is carried out oral stimulation measurement, result such as table 12.
Table 12
| Component | Average salivation amount before and after using | PH before and after using | Lactobacillus amount before and after using |
| Embodiment 13 described oral cavity nursing agents | Constant | Constant | Reduce |
| 0.05% TPC aqueous solution | Constant | Increase | Reduce |
| 0.05% 1,6-two (4-chlorphenyl biguanide) hexane diacetate aqueous solution | Constant | Increase | Reduce |
| 0.2% aluminum chloride aqueous solution | Reduce | Increase | Reduce |
| 0.2% solder(ing)acid | Reduce | Increase | Reduce |
Claims (7)
1. oral cavity nursing agent, contain following component by weight percentage:
(a) quaternary ammonium salt 0.03～0.1%;
(b) biguanide 0.01～0.08%;
(c) non-ionic surface active agent 0.5～4.0%;
(d) zinc-aluminium polyprotic acid complex 0.1～3.0%;
(e) hydrophilic solvent 20～25%;
(f) enzyme inhibitor 0.5～1.0%;
(g) surplus is a water;
Wherein:
Quaternary amine is wherein one or more mixture of chlorination octadecyl dimethylbenzyl ammonium, TPC, cetylpyridinium chloride, chlorination dodecyl dimethyl (2-benzene oxygen ethyl) ammonium;
Biguanide is 1,6-two (4-chlorphenyl biguanide) hexane dihydrochloride, 1, and 6-two (4-chlorphenyl biguanide) hexane diacetate and 1,6-two (4-chlorphenyl biguanide) hexane two Fructus Vitis viniferae hydrochlorates are one or more mixture wherein;
Non-ionic surface active agent is wherein one or more mixture of Nonyl pheno, octyl phenol polyoxy ethylene, decyl dimethyl oxidation amine, polyoxyethylene sorbitan monooleate dehydration, lauryl dimethyl amine oxide, octyldimethyl amine oxide, myristyl dimethyl amine oxide:
Hydrophilic solvent is methanol, ethanol, propanol, isopropyl alcohol, butanols, isobutanol, ethylene glycol, propylene glycol, 1, ammediol, phenyl phenol, 1-phenoxypropanol, and the 2-phenoxypropanol is one or more mixture wherein;
Enzyme inhibitor is wherein one or more mixture of trimethyl citrate, citric acid three propyl ester, citric acid dibutyl ester;
Zinc-aluminium polyprotic acid complex is M
aAl
bZn
cB
d, M is potassium ion or sodium ion or ammonium ion; B is wherein one or more mixture of citric acid, tartaric acid, malic acid, succinic acid, maleic acid; C: b is 4: 1～1: 1; (b+c): d is 1: 1.3～1: 2.
2. according to the described oral cavity nursing agent of claim 1, wherein c: b is 2: 1～1: 1 in the zinc-aluminium polyprotic acid complex, and (b+c): d is 1: 1.3～1: 2.
3. according to the described oral cavity nursing agent of claim 2, wherein c: b is 1.5: 1 in the zinc-aluminium polyprotic acid complex, and (b+c): d is 1: 1.5.
4. according to the described oral cavity nursing agent of claim 1, wherein zinc-aluminium polyprotic acid complex is M
21Al
4Zn
6B
15, M is potassium ion or sodium ion or ammonium ion; B is a citric acid.
5. according to the described oral cavity nursing agent of claim 1, wherein zinc-aluminium polyprotic acid complex is M
6Al
4Zn
6B
15, M is potassium ion or sodium ion or ammonium ion; B is tartaric acid, malic acid, maleic acid, one or more mixture of succinic acid.
6. according to the described oral cavity nursing agent of one of claim 1～5, wherein zinc-aluminium polyprotic acid complex consumption is 0.5～1.5% (weight).
7. according to the described oral cavity nursing agent of claim 1, the Eucalyptus oil, menthol, cresotic acid, thymol that it is characterized in that also containing 0.01～5% weight be one or more mixture wherein; 0.1 the sodium alginate of～0.5% weight, xanthan gum, hydroxyethyl-cellulose, methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, PVP, guar gum be one or more mixture wherein.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100523087A CN1314384C (en) | 2004-11-22 | 2004-11-22 | Oral cavity nursing agent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100523087A CN1314384C (en) | 2004-11-22 | 2004-11-22 | Oral cavity nursing agent |
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| Publication Number | Publication Date |
|---|---|
| CN1778288A CN1778288A (en) | 2006-05-31 |
| CN1314384C true CN1314384C (en) | 2007-05-09 |
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ID=36768827
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100523087A Expired - Fee Related CN1314384C (en) | 2004-11-22 | 2004-11-22 | Oral cavity nursing agent |
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| EP3454828A4 (en) * | 2016-05-10 | 2019-12-11 | Colgate-Palmolive Company | Alginate dentifrice compositions and methods of making thereof |
| CN109260925A (en) * | 2018-09-25 | 2019-01-25 | 深圳市爱康泉水处理服务有限公司 | Environment-friendly type deodorant composition and deodorant and its application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138477A (en) * | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
| US4183916A (en) * | 1978-03-31 | 1980-01-15 | Beecham Inc. | Oral compositions |
| US4188372A (en) * | 1976-12-27 | 1980-02-12 | Colgate-Palmolive Company | Antibacterial oral composition |
| US4937066A (en) * | 1989-06-22 | 1990-06-26 | David G. Vlock | Zinc containing oral compositions |
| US5028412A (en) * | 1987-05-01 | 1991-07-02 | Purdue Research Foundation | Oral compositions comprising anti-calculus agents |
| US6277359B1 (en) * | 1999-01-29 | 2001-08-21 | Cognis Deutschland Gmbh | Deodorizing formulation |
| US6303111B1 (en) * | 1999-06-08 | 2001-10-16 | National Research Labs | Nontoxic biocompatible deodorizing compositions |
-
2004
- 2004-11-22 CN CNB2004100523087A patent/CN1314384C/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138477A (en) * | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
| US4188372A (en) * | 1976-12-27 | 1980-02-12 | Colgate-Palmolive Company | Antibacterial oral composition |
| US4183916A (en) * | 1978-03-31 | 1980-01-15 | Beecham Inc. | Oral compositions |
| US5028412A (en) * | 1987-05-01 | 1991-07-02 | Purdue Research Foundation | Oral compositions comprising anti-calculus agents |
| US4937066A (en) * | 1989-06-22 | 1990-06-26 | David G. Vlock | Zinc containing oral compositions |
| US6277359B1 (en) * | 1999-01-29 | 2001-08-21 | Cognis Deutschland Gmbh | Deodorizing formulation |
| US6303111B1 (en) * | 1999-06-08 | 2001-10-16 | National Research Labs | Nontoxic biocompatible deodorizing compositions |
Non-Patent Citations (4)
| Title |
|---|
| 化学消毒剂 吴祺，中学化学教学参考，第11期 2003 * |
| 化学消毒剂 吴祺，中学化学教学参考，第11期 2003;抗菌剂的研究进展 魏秋华，中国消毒学杂志，第20卷第1期 2003;阳离子表面活性剂在医学及微生物学上的新用途 徐立林，日用化学品科学，第4期 1997 * |
| 抗菌剂的研究进展 魏秋华，中国消毒学杂志，第20卷第1期 2003 * |
| 阳离子表面活性剂在医学及微生物学上的新用途 徐立林，日用化学品科学，第4期 1997 * |
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| CN1778288A (en) | 2006-05-31 |
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