CN1369206A - Nano Silver sterilizing gel, its preparing method and use - Google Patents
Nano Silver sterilizing gel, its preparing method and use Download PDFInfo
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- CN1369206A CN1369206A CN 01143404 CN01143404A CN1369206A CN 1369206 A CN1369206 A CN 1369206A CN 01143404 CN01143404 CN 01143404 CN 01143404 A CN01143404 A CN 01143404A CN 1369206 A CN1369206 A CN 1369206A
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Abstract
A disinfecting nano silver gel for treating bacterial vaginitis, prostatitis, burn, scald, wound, etc. contains pharmacologically receptable additive, carrier, and broad-spectrum antibacterial nano silver particles (0.1-0.4%) with 1-100 nm of granularity.
Description
One, technical field
The invention relates to a kind of antibacterials that adopt Nano Silver, more particularly, is about a kind of nano Silver sterilizing gel and its production and application.
Two, background technology
The physicochemical characteristics of nanometer technology (i.e. 0.1～100 nanometer) material that is research circle between size field between macrocosm and the microcosmos in this interval, because it both had been different from macroscopic view, is different from microcosmic again.Therefore determine in the nanometer technology in the 90 years U.S., this section definition is seen for being situated between, both kept the atom form of material at the material that is situated between in seeing in macrostate, again because the variation of atomic arrangement, produced small-size effect, quantum effect, made material have extraordinary adsorptivity, diffusibility and surface-active.Use the life style that these characteristics can change people, produce new revolution in many industries, it is the termination of engineering.
Silver just is used to treatment knife wound, arrow as far back as the ancient times hinders, and ancient times three, state well-known doctor Huatuo was that the pass public affairs are scraped bone and cured the wound with silver-colored cutter just, and Compendium of Material Medica is on the books to the sterilization disease cure function of silver." infrastructure elements chemistry " described like this to silver: silver has peculiar effect as bactericidal agent, and 1% liquor argenti nitratis ophthalmicus is the medicine commonly used of treatment eye conjunctivitis.Argent has strong bactericidal action, just can kill 50 tons of bacteriums in the water according to measuring and calculating 1 gram silver, and to the person poultry harmless.Cover the wound that festers with the argentiferous gauze, can eliminate infection rapidly, and adhesion skin and flesh, filamentary silver can be used for sewing up a wound, and the silver band can be used for fixation of bone fragments, and silver strip can be used for filling up broken hole on the skull, and silver is " the one's own thing metal " that uses the earliest.
Aspect clinical use, anti-infectious agent has accounted for 1/3rd of total dosage, but it is undesirable, all think " bacterium is resistance more and more; antibiotic more and more lost efficacy ", reason just is that these antibiotic, sulfonamides etc. all are to block or suppress bacterial metabolism growth by the change of chemical constitution, this link is not all right, just change a link, be called the second generation, third generation antibiotic, most of bacterium is suppressed death, gets off but always some bacterium is remaining, their next generation just adapts to these medicines by changing gene, promptly produces drug resistance.
Three, goal of the invention
One of purpose of the present invention provides a kind of nano Silver sterilizing gel.
Two of purpose of the present invention provides a kind of nano Silver sterilizing gel for the treatment of bacterial vaginitis.
Three of purpose of the present invention provides a kind of preparation method of nano Silver sterilizing gel.
These and other objects of the present invention will and be described by following detailed description and further embody and illustrate.
Four, summary of the invention
Nano Silver sterilizing gel of the present invention, except that containing pharmaceutically acceptable additives, also contain the wide-spectrum antiseptic nanometer silver particle, the particle diameter of this nano-Ag particles is 1～100 nanometer, nano silver particles is loaded on the carrier, and nano-Ag particles accounts for 0.1～0.4% of disinfecting gel weight.
Further, nano Silver sterilizing gel of the present invention is except that containing pharmaceutically acceptable additives, also contain the wide-spectrum antiseptic nanometer silver particle, the particle diameter of this nano-Ag particles is 1～100 nanometer, and nano silver particles is loaded on the rush carrier, and nano-Ag particles accounts for 1～3% of disinfecting gel weight.
In nano Silver sterilizing gel of the present invention, described carrier can be plant vector or inorganic mineral carrier, this kind carrier has great surface area and the many micropores of numbers of poles, described pharmaceutically acceptable additives comprise one of monomer carrier, surfactant, dispersant and transdermal enhancer or their mixture, can be the two or three or fours' mixtures.
Nano Silver sterilizing gel of the present invention, described reagent combination is (in 1000 gram gel weight):
Nano-Ag particles 1～4 gram, poly-carboxylic ethamine 5～12 grams,
8～15 milliliters of triethanolamines, surplus distilled water.
Be preferably, nano Silver sterilizing gel of the present invention, described reagent combination is (in 1000 gram gel weight):
Nano-Ag particles 1～3 gram, poly-carboxylic ethamine 6～10 grams,
10～15 milliliters of triethanolamines, surplus distilled water.
Best is that nano Silver sterilizing gel of the present invention, described reagent combination are (in 1000 gram gel weight):
Nano-Ag particles 1～2 gram, poly-carboxylic ethamine 7～8 grams,
10～12 milliliters of triethanolamines, surplus distilled water.
In nano Silver sterilizing gel of the present invention, described poly-carboxylic ethamine (carbomer) can use one of synthetic or natural polymer such as starch based derivative (sodium carboxymethyl starch, HES, pregelatinized starch), cellulose derivatives (methylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, hydroxyethylcellulose), polyvinylpyrrolidone, alginic acid xanthans or mixture to replace.
The preparation method of nano Silver sterilizing gel of the present invention is by proportional quantity nano-Ag particles, poly-carboxylic ethamine and triethanolamine at room temperature to be stirred, and then adds distilled water continuation stirring 1～2 hour that be cooled under stirring and solidify, packing gets final product.
In the present invention, if necessary, can also increase some conventional processing methods, can certainly comprise and rely on the conventional knowledge of this specialty to omit one or more steps, just can make qualified product by actual conditions.
In like manner, in the present invention, also can increase some additives or host according to the purpose of actual needs and raising curative effect, this is also among the present invention.
Nano Silver sterilizing gel of the present invention can pass through vagina administration, the treatment bacterial vaginitis, by rectally treatment male prostate inflammation, by combining with other additive or excipient, make therapeutic type face cream, facial mask, face washing liquid, foam body lotion etc., also can be used for the prevention and the sterilization of burn and scald, wound, operative incision trauma surface infestation and ulcer, impel wound healing.
Antibiotic mechanism of the present invention is to utilize the principle of " Ag makes thalline sex change or precipitation " in the classical theory " medical microorganism ", by Ag+ and mycoprotein enzyme-the SH base combines, make as necessary basic enzyme loss of activity and can't survive, thereby realize killing pathogenic bacteria, repair pathological tissues, promote wound healing to have the effect of treatment and pre-bacteriological protection, fungi.
Its sterilization mechanism is:
In the present invention, can adopt Guangzhou Anxin Biotechnology Development Co., Ltd to produce antibacterial granule, this product and manufacture method thereof have obtained Chinese patent, the patent No. is: 94118576.1, name is called: the preparation method of long-acting broad-spectrum antibacterial particle and goods thereof, this patent is listed in for your guidance at this, the silver particle that is loaded with on this micro mist, and detecting its particle diameter through scanning tunneling microscope is 1～100 nanometer.
Product of the present invention can and directly be coated in injured or the infection site administration by vagina or rectum, also can be coated in medium and comprise administration on the fabric, the particle diameter of the Nano Silver of Cai Yonging is 1～100 nanometer in the present invention, and the particle diameter of silver particle reduces, the atomicity that is in superficial layer is increased sharply, cause former coordination deficiency, unsaturated bond exposes and increases, the surface of atom can be increased, so have extremely strong chemism, add that particle diameter is a nanoscale, so these Nano Silvers have the ability of well oozing thoroughly, the sterilizing function of the excellence of Nano Silver, so nano Silver sterilizing gel of the present invention simultaneously can be treated vaginitis and other inflammation.
Nano Silver sterilizing gel of the present invention is through institute of microbiology of Hong Kong University, Institute of Microorganism, Academia Sinica, Chinese Academy of Medical Sciences's skin disease, VDRL (national venereal disease prevention center), the detection of institute of microbiology of China Preventive Medicial Science Institute, new drug security evaluation center, China national Beijing and Physical and Chemical Inst. of Peking University proves, have long-acting, efficient, broad-spectrum sterilization, nontoxic, non-stimulated, thing is irritated, have no drug resistance, and dosage is little, the effect height is desirable natural disinfection material.
Table 1
Nano Silver sterilizing gel detects antibacterial, the sterilization of common resistance pathogenic organisms
| Microbial name | Mlc (ug/ml) | Bacteriocidal concentration (ug/ml) |
| Escherichia coli | ????＞15＜20 | ????＞45＜50 |
| Staphylococcus aureus | ????＞35＜40 | ????＞35＜40 |
| Pseudomonas aeruginosa | ????＞30＜35 | ????＞70＜80 |
| Bacillus subtilis | ????＞15＜20 | ????＞100 |
| The candida albicans bacterium | ????＞91＜104 | ????＞130 |
Result of the test shows, above pathogenic microorganisms all there is the effect of strong pressing down property, Escherichia coli, staphylococcus aureus and pseudomonas aeruginosa there is killing action, when concentration is 50ug/ml, act on 30 minutes colibacillary killing rate is reached 85.55%, act on 24 hours to colibacillary sterilizing rate and can reach 100%.
Table 2
Nano Silver sterilizing gel detects antibacterial, the sterilization of sexually transmitted disease pathogenic microorganism
| Microbial name | Bacteriocidal concentration (ug/ml) | Action time (minute) |
| Gonococcus | ????10 | ????1 |
| ????2.5 | ????5 | |
| Trachoma is according to substance | ????2.03 | ????1 |
Result of the test shows that nanogel of the present invention all has killing action to causing the gonococcus, the trachoma that spread through sex intercourse according to substance, when concentration is that gonococcus was killed in 10ug/ml (being equivalent to 100,000/gram) effect in 1 minute; Concentration is 2.03ug/ml, acts on 1 minute and promptly kills trachoma according to substance.
This product can suppress and kill each bacterioid, and as pathogenic bacteria such as staphylococcus aureus, Escherichia coli, gonococcus, candida albicans, Pseudomonas aeruginosa, micrococcus scarlatinae, bacillus subtilis, pneumobacillus, anaerobic bacterias, he can kill trachoma according to substance.Safety testing surface this product avirulence, no hypersensitivity, to skin, mucous membrane nonirritant, no teratogenesis, rapid-action, good effect has no side effect.
This product is met water can quicken the release of Nano Silver, so chance water sterilizing power is stronger.
In the present invention, when using assistant agent or additive all can buy from market, further, also can adopt in the industry the conventional phase class of using with product.
Below further specify the present invention by specific embodiment, can not limit the scope of the invention but embodiment only is used for explanation, if not refer in particular to all parts in the present invention, measure the heavy unit be based on gross weight.
Five, embodiment
Example 1:
By application number is 94118576.1, and name is called: the described method of the preparation method of long-acting broad-spectrum antibacterial particle and goods thereof prepares the broad-spectrum antiseptic particle.
A, get common rush stem marrow siccative 100 gram, be crushed to the millimeter level, standby;
B, take by weighing that 5～20 gram silver nitrates are dissolved in 500 ml waters and 50～100 milliliters of concentrated ammonia liquors in, be diluted to 1000 milliliters after the dissolving, shake up, in this solution, add the solution (50 milliliters of volumes) that contains 3～10 gram dimension C again, drop into the particle that the A step obtains immediately, under ventilation condition, soak, push and then soak, push, heat-treat subsequently, soak, push, dry the broad-spectrum antiseptic particle that promptly must ask at last again.
Example 2:
Take by weighing following raw materials according in following ratio
Nano-Ag particles 1 gram, poly-carboxylic ethamine 6 grams, 9 milliliters of triethanolamines,
Distilled water 9984 grams.
Preparation by the following method:
By the said ratio amount nano-Ag particles, poly-carboxylic ethamine and triethanolamine are at room temperature stirred, and then add distilled water continuation stirring 1.5 hours, be cooled under stirring and solidify, packing is promptly taken charge of.
Example 3:
Take by weighing following raw materials according in following ratio:
Nano-Ag particles 3.5 grams, poly-carboxylic ethamine 12 grams, 15 milliliters of triethanolamines,
Distilled water 9969.5 grams.
Preparation by the following method:
By the said ratio amount nano-Ag particles, poly-carboxylic ethamine and triethanolamine are at room temperature stirred, and then add distilled water continuation stirring 1.9 hours, be cooled under stirring and solidify, packing gets final product.
Example 4
Take by weighing following raw materials according in following ratio:
Nano-Ag particles 2.5 grams, poly-carboxylic ethamine 10 grams, 12 milliliters of triethanolamines,
Distilled water 9975.5 grams.
Preparation by the following method:
By the said ratio amount nano-Ag particles, poly-carboxylic ethamine and triethanolamine are at room temperature stirred, and then add distilled water continuation stirring 1.8 hours, be cooled under stirring and solidify, packing gets final product.
Example 5
Take by weighing following raw materials according in following ratio:
Nano-Ag particles 1.5 grams, HES 9 grams, 12 milliliters of triethanolamines,
Distilled water 9977.5 grams.
Preparation by the following method:
By the said ratio amount nano-Ag particles, poly-carboxylic ethamine and triethanolamine are at room temperature stirred, and then add distilled water continuation stirring 1.5 hours, be cooled under stirring and solidify, packing gets final product.
Example 6
Take by weighing following raw materials according in following ratio:
Nano-Ag particles 1.5 grams, poly-carboxylic ethamine 8 grams, 12 milliliters of triethanolamines,
Distilled water 9978.5 grams.
Preparation by the following method:
By the said ratio amount nano-Ag particles, poly-carboxylic ethamine and triethanolamine are at room temperature stirred, and then add distilled water continuation stirring 1.5 hours, be cooled under stirring and solidify, packing gets final product.
Example 7
Take by weighing following raw materials according in following ratio:
Nano-Ag particles 1.7 grams, polyvinylpyrrolidone 10 grams, 12 milliliters of triethanolamines,
Distilled water 9976.3 grams.
Preparation by the following method:
By the said ratio amount nano-Ag particles, poly-carboxylic ethamine and triethanolamine are at room temperature stirred, and then add distilled water continuation stirring 1.5 hours, be cooled under stirring and solidify, packing gets final product.
Example 8
Nano-Ag particles 1.6 grams, polyvinylpyrrolidone 5 grams,
Methylcellulose 4 grams, 12 milliliters of triethanolamines,
Distilled water 9977.4 grams.
Preparation by the following method:
By the said ratio amount nano-Ag particles, poly-carboxylic ethamine and triethanolamine are at room temperature stirred, and then add distilled water continuation stirring 1.5 hours, be cooled under stirring and solidify, packing gets final product.
Claims (10)
1, a kind of nano Silver sterilizing gel, it is characterized in that also containing the wide-spectrum antiseptic nanometer silver particle except that containing pharmaceutically acceptable additives, the particle diameter of this nano-Ag particles is 1～100 nanometer, nano silver particles is loaded on the carrier, and nano-Ag particles accounts for 0.1～0.4% of disinfecting gel weight.
2, nano Silver sterilizing gel as claimed in claim 1, it is characterized in that except that containing pharmaceutically acceptable additives, also contain the wide-spectrum antiseptic nanometer silver particle, the particle diameter of this nano-Ag particles is 1～100 nanometer, nano silver particles is loaded on the rush carrier, and nano-Ag particles accounts for 1～3% of disinfecting gel weight.
3, nano Silver sterilizing gel as claimed in claim 1 is characterized in that described carrier can be plant vector or inorganic mineral carrier, and this kind carrier has great surface area and the many micropores of numbers of poles.
4, nano Silver sterilizing gel as claimed in claim 1 is characterized in that described pharmaceutically acceptable additives comprise monomer carrier, surfactant, dispersant and transdermal enhancer.
5,, it is characterized in that described reagent combination is (in 1000 gram gel weight) as the described nano Silver sterilizing gel of claim 1～4:
Nano-Ag particles 1～4 gram, poly-carboxylic ethamine 5～12 grams,
8～15 milliliters of triethanolamines, surplus distilled water.
6, nano Silver sterilizing gel as claimed in claim 5 is characterized in that described reagent combination is (in 1000 gram gel weight):
Nano-Ag particles 1～3 gram, poly-carboxylic ethamine 6～10 grams,
10～15 milliliters of triethanolamines, surplus distilled water.
7, nano Silver sterilizing gel as claimed in claim 5 is characterized in that described reagent combination is (in 1000 gram gel weight):
Nano-Ag particles 1～2 gram, poly-carboxylic ethamine 7～8 grams,
10～12 milliliters of triethanolamines, surplus distilled water.
8, nano Silver sterilizing gel as claimed in claim 5 is characterized in that described poly-carboxylic ethamine can use one of starch based derivative, cellulose derivatives, polyvinylpyrrolidone, alginic acid xanthans or mixture to replace.
9, as the preparation method of the described nano Silver sterilizing gel of claim 5～7, it is characterized in that nano-Ag particles, poly-carboxylic ethamine and triethanolamine at room temperature being stirred by proportional quantity, and then add distilled water continuation stirring 1～2 hour, and being cooled under stirring and solidifying, packing gets final product.
10,, it is characterized in that to pass through vagina administration the treatment bacterial vaginitis as the application of the described nano Silver sterilizing gel of claim 1～3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01143404 CN1369206A (en) | 2001-12-26 | 2001-12-26 | Nano Silver sterilizing gel, its preparing method and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01143404 CN1369206A (en) | 2001-12-26 | 2001-12-26 | Nano Silver sterilizing gel, its preparing method and use |
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| Publication Number | Publication Date |
|---|---|
| CN1369206A true CN1369206A (en) | 2002-09-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01143404 Pending CN1369206A (en) | 2001-12-26 | 2001-12-26 | Nano Silver sterilizing gel, its preparing method and use |
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| CN (1) | CN1369206A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005120173A3 (en) * | 2004-05-12 | 2006-04-27 | Kishore Madhukar Paknikar | Anti-microbial activity of biologically stabilized silver nano particles |
| WO2007017901A2 (en) * | 2005-06-08 | 2007-02-15 | Khandelwal Sanjeev | Silver nanoparticle dispersion formulation |
| CN100396290C (en) * | 2006-11-03 | 2008-06-25 | 段炬红 | External use anti-bacteria foaming agent for gynecology |
| CN100425375C (en) * | 2006-04-03 | 2008-10-15 | 庄平 | Nano-class silver colloidal solution and preparation method thereof |
| CN100457084C (en) * | 2006-08-04 | 2009-02-04 | 武汉正午阳光医药生物科技有限公司 | Nanometer silver type external use antibiotic gel for female external use and its prepn. method |
| CN102310200A (en) * | 2011-08-24 | 2012-01-11 | 明基材料有限公司 | Nano silver particle forming method |
| US8192764B2 (en) | 2006-01-13 | 2012-06-05 | 3M Innovative Properties Company | Silver-containing antimicrobial articles and methods of manufacture |
| US8399027B2 (en) | 2005-04-14 | 2013-03-19 | 3M Innovative Properties Company | Silver coatings and methods of manufacture |
| CN103083472A (en) * | 2013-01-25 | 2013-05-08 | 北海光谷纳米科技研发中心 | Nano silver anti-inflammatory gel for treating gynecologic inflammation and preparation method thereof |
| CN103493849A (en) * | 2013-08-27 | 2014-01-08 | 利辛县永强精炼油脂厂 | Rose essential oil disinfection gel |
| CN106074364A (en) * | 2016-07-20 | 2016-11-09 | 国家纳米科学中心 | A kind of antibacterial gel containing nanometer gold |
| CN109331208A (en) * | 2018-11-02 | 2019-02-15 | 江门市和馨香精技术有限公司 | A kind of air cleaning gel and preparation method thereof with cream texture |
-
2001
- 2001-12-26 CN CN 01143404 patent/CN1369206A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005120173A3 (en) * | 2004-05-12 | 2006-04-27 | Kishore Madhukar Paknikar | Anti-microbial activity of biologically stabilized silver nano particles |
| EA013401B1 (en) * | 2004-05-12 | 2010-04-30 | Нано Каттинг Эдж Текнолоджиз Пвт. Лтд. | Antimicrobial activity of biologically stabilized silver nano particles |
| US8399027B2 (en) | 2005-04-14 | 2013-03-19 | 3M Innovative Properties Company | Silver coatings and methods of manufacture |
| WO2007017901A2 (en) * | 2005-06-08 | 2007-02-15 | Khandelwal Sanjeev | Silver nanoparticle dispersion formulation |
| WO2007017901A3 (en) * | 2005-06-08 | 2007-06-14 | Khandelwal Sanjeev | Silver nanoparticle dispersion formulation |
| US8192764B2 (en) | 2006-01-13 | 2012-06-05 | 3M Innovative Properties Company | Silver-containing antimicrobial articles and methods of manufacture |
| US9289450B2 (en) | 2006-01-13 | 2016-03-22 | 3M Innovative Properties Company | Silver-containing antimicrobial articles and methods of manufacture |
| CN100425375C (en) * | 2006-04-03 | 2008-10-15 | 庄平 | Nano-class silver colloidal solution and preparation method thereof |
| CN100457084C (en) * | 2006-08-04 | 2009-02-04 | 武汉正午阳光医药生物科技有限公司 | Nanometer silver type external use antibiotic gel for female external use and its prepn. method |
| CN100396290C (en) * | 2006-11-03 | 2008-06-25 | 段炬红 | External use anti-bacteria foaming agent for gynecology |
| CN102310200A (en) * | 2011-08-24 | 2012-01-11 | 明基材料有限公司 | Nano silver particle forming method |
| CN102310200B (en) * | 2011-08-24 | 2014-09-03 | 明基材料有限公司 | Nano silver particle forming method |
| CN103083472A (en) * | 2013-01-25 | 2013-05-08 | 北海光谷纳米科技研发中心 | Nano silver anti-inflammatory gel for treating gynecologic inflammation and preparation method thereof |
| CN103493849A (en) * | 2013-08-27 | 2014-01-08 | 利辛县永强精炼油脂厂 | Rose essential oil disinfection gel |
| CN106074364A (en) * | 2016-07-20 | 2016-11-09 | 国家纳米科学中心 | A kind of antibacterial gel containing nanometer gold |
| CN109331208A (en) * | 2018-11-02 | 2019-02-15 | 江门市和馨香精技术有限公司 | A kind of air cleaning gel and preparation method thereof with cream texture |
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