CN1373760A - 作为毒蕈碱性m3受体配体的奎宁环衍生物及其用途 - Google Patents
作为毒蕈碱性m3受体配体的奎宁环衍生物及其用途 Download PDFInfo
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- CN1373760A CN1373760A CN00812754A CN00812754A CN1373760A CN 1373760 A CN1373760 A CN 1373760A CN 00812754 A CN00812754 A CN 00812754A CN 00812754 A CN00812754 A CN 00812754A CN 1373760 A CN1373760 A CN 1373760A
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Abstract
Description
化合物号 | 对受体M3的结合(IC50nM) |
阿托品 | 3.2 |
IPRATROPIUM | 3.0 |
1 | 31 |
2 | 15 |
7 | 22 |
8 | 4.8 |
17 | 14 |
18 | 6.6 |
20 | 6.8 |
35 | 13 |
36 | 2.7 |
39 | 3.8 |
44 | 4.4 |
53 | 5.6 |
71 | 8.2 |
74 | 16 |
77 | 3.1 |
78 | 5 |
84 | 9.9 |
89 | 5.4 |
99 | 31 |
100 | 14 |
101 | 7.6 |
109 | 31 |
114 | 14 |
116 | 23 |
126 | 13 |
127 | 16 |
128 | 8.8 |
129 | 6.3 |
136 | 11 |
137 | 6.9 |
138 | 19 |
146 | 13 |
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