CN1449691A - Anti-heatstroke effervescent beverage - Google Patents
Anti-heatstroke effervescent beverage Download PDFInfo
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- CN1449691A CN1449691A CN 02103882 CN02103882A CN1449691A CN 1449691 A CN1449691 A CN 1449691A CN 02103882 CN02103882 CN 02103882 CN 02103882 A CN02103882 A CN 02103882A CN 1449691 A CN1449691 A CN 1449691A
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- beverage
- cobastab
- vitamin
- heatstroke
- sulfate
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Abstract
The present invention relates to an effervescent beverage with the function of anti-heatstroke. Said beverage has no need of stirring, can be quickly self-dissolved to form beverage. Its composition contains citric acid, sodium citrates, NaHCO3, aspartame, essence, potassium chloride, calcium chloride, magnesium sulfate, iron sulfate, zinc sulfate, vitamin B1, vitamin B2, vitamin B6, vitamin A, vitamin E, vitamin C and nicotinic acid. Said invented beverage has the action of raising antioxygenic powder of body, and possesses the function of effectively anti-heatstroke.
Description
Technical field
The invention belongs to field of beverage, especially a kind of effervescent beverage(s) with anti-heatstroke function.
Background technology
The technology of relevant effervescent beverage(s) is a lot of in the prior art, but the effervescent beverage(s) with the such specific function of anti-heatstroke did not also occur.As disclosing a kind of effervescing multi-vitamin beverage tablet and manufacture method among the Chinese patent CN1204479A, the effect of certain extra-nutrition is arranged, have the such specific function of anti-heatstroke but but can't reach.Heatstroke is meant by human body thermal balance imbalance under thermal environment, water and salt metabolic disturbance or cause the caused a kind of acute general name of crossing febrile illness of brain tissue impairment because of sunlight direct projection head.Army marches under thermal environment or when training, the soldier can lose big water gaging salt because of perspiration, if untimely reasonable supplement, to cause that water and salt metabolic disturbance, the dehydration salt deficiency raises body temperature rapidly, and heart rate is accelerated, efficiency reduces, even the thermic disease takes place, comprising heatstroke.Heatstroke is to cause one of key factor of military operation non-combat casualty under the thermal environment, therefore can not be ignored, and " supplementing water salt " is " the effectively tactical weapon " of prevention fire damage.My army very payes attention to replenishing also of human body water salt under the thermal environment, has not only carried out correlative study, and has determined the effervescent beverage(s) that uses under the thermal environment.The maximum characteristics of this effervescent beverage(s) are to replenish the water salt loss of human body under thermal environment, prevention heatstroke fast.
Summary of the invention
The every advantage that the objective of the invention is not only have common beverages after the dissolving of prepared medicine materical crude slice and had need not stir and can generate beverage by quick autolysis, and have the function of anti-heatstroke simultaneously.
The present patent application people is through a large amount of mensuration and test, makes a kind of effervescent beverage(s) with anti-heatstroke specific function strictly according to human sweat's the one-tenth proportioning of assigning to, and according to the production method of effervescent tablet conventional in the prior art.
Effervescent beverage(s) proportioning: (every dosage)
Citric acid 1400-1600mg, natrium citricum 45-55mg, NaHCO
3600-900mg, Aspartame 250-350mg, essence 180-220mg, potassium chloride 115-125mg, calcium chloride 18-22mg, magnesium sulfate 8-12mg, ferric sulfate 2-8mg, zinc sulfate 1.8-2.2mg, Cobastab
10.5-0.7mg, Cobastab
20.3-0.5mg, Cobastab
60.4-0.6mg, dehydroretinol 30-270 μ g, vitamin E2 .3-2.7mg, Catergen 2-27mg, nicotinic acid 0.11-0.13mg.
The preferred proportioning of effervescent beverage(s): (every dosage)
Citric acid 1450-1550mg, natrium citricum 48-52mg, NaHCO
3750-850mg, Aspartame 280-320mg, essence 190-210mg, potassium chloride 118-122mg, calcium chloride 19-21mg, magnesium sulfate 9-11mg, ferric sulfate 4-6mg, zinc sulfate 1.9-2.1mg, Cobastab
10.55-0.65mg, Cobastab
20.35-0.45mg, Cobastab
60.45-0.55mg, dehydroretinol 40-260 μ g, vitamin E2 .4-2.6mg, Catergen 3-26mg, nicotinic acid 0.115-0.125mg.
Most preferred proportioning: (every dosage)
Citric acid 1500mg, natrium citricum 50mg, NaHCO
3750mg, Aspartame 300mg, essence 200mg, potassium chloride 120mg, calcium chloride 20mg, magnesium sulfate 10mg, ferric sulfate 5mg, zinc sulfate 2mg, Cobastab
10.6mg, Cobastab
20.4mg, Cobastab
60.5mg, dehydroretinol 50 μ g, vitamin E2 .5mg, Catergen 5mg, nicotinic acid 0.125mg.
The base-material of beverage of the present invention is to can be used as edible conventional beverage assistant agent, comprising filler, diluent, wetting agent, granulating agent, lubricant, adhesive, disintegrant etc.Preferred filler comprises starch, glucose, sucrose, lactose, sweet mellow wine, calcium phosphate, calcium carbonate, cellulose.Preferred lubricant comprises talcum powder, CMS, polyvinylpyrrolidone (PVP) and silica gel, dolomol etc.Wetting agent comprises water, ethanol, syrup etc., and diluent comprises starch, glucose, lactose etc., and adhesive comprises dextrin, starch slurry, syrup etc., and disintegrant comprises starch, microcrystalline cellulose etc.Selected any composition and consumption depend on many factors, comprise the concentration of beverage formulations, functional component etc.In the scope that does not break away from essence of the present invention, those skilled in the art can design proper formula, comprises selecting composition and consumption arbitrarily.
The manufacture method of effervescent beverage(s) is as follows:
One, raw and auxiliary material requires:
1, citric acid: water white transparency crystallization or white particle, odorless has the strong acid flavor, relative density 1.655, citric acid content 〉=99.5%, other indexs meet regulation requirement among the GB1987-86.
2, vitamin C: water white transparency crystallization or white particle powder, odorless, flavor are salty, refrigerant sense are arranged, relative density 1.980, dry back content 〉=99.0%, loss on drying 3.0～6.0%.
3, white granulated sugar: sucrose 〉=99.0%, reduced sugar≤0.15%, ash content≤0.1%, color and luster is pure white, and other indexs meet regulation requirement among the GB317.
4, Aspartame: white crystalline powder, odorless has intense sweetness, sweet taste threshold value 0.001～0.007%, PH4.5～5.5, loss on drying≤4.0%, ignition residue≤0.2%.
5, sodium acid carbonate: white powder, odorless, other indexs meet the requirement of GB-1887-90 regulation.
6, vitamin A: meet regulation requirement among the GB14750-93.
7, Cobastab
1: meet regulation requirement among the GB14751-93.
8, Cobastab
2: meet regulation requirement among the GB14752-93.
9, Cobastab
6: meet regulation requirement among the GB14753-93.
10, vitamin C: meet regulation requirement among the GB14754-93.
11, vitamin D: meet regulation requirement among the GB14755-93.
12, vitamin E: meet regulation requirement among the GB14756-93.
13, natural essence: meet regulation requirement among the GB-2760-1996.
14, pigment: meet regulation requirement among the GB-2760-1996.
Two, production technology:
1, production technology is briefly described as follows:
Ingredient inspection → pulverizing → batching → mixing → system softwood → granulating and forming → oven dry → cooling → whole grain → compressing tablet → packing.
2, detailed process step:
(1) ingredient inspection: the raw material that uses in producing is tested by the related request of stipulating in the national standard.
(2) raw material pulverizing: before batching that granularity is big raw material such as citric acid, white granulated sugar etc. are pulverized on pulverizer in advance, and cross 100 mesh sieves.The purpose of raw material pulverizing is in order to guarantee that tablet is aesthetic in appearance, the color and luster homogeneous, raw material to be mixed in process, thereby guarantees the quality stability of tablet.
(3) batching, mixing: pour primary raw material into mixer in proportion, start agitator raw material is mixed.For guaranteeing the abundant mixing of each raw material in the tablet, trace in the batching or minor constituent adopt equivalent to increase progressively mixing method step by step with mixing of primary raw material.
(4) system softwood: on mixed material, spray pigment solution.
(5) granulating and forming: the softwood that makes is caused 14 purpose particles on granulator, the particle of making places square pallet stand-by.
(6) drying: the wet granular in the square pallet is placed 70 ℃ of oven dry taking-ups after 1 hour down, in dry environment cooling down.
(7) whole grain: a part of particle caking that may stick to each other in dry run, be unsuitable for the compressing tablet requirement, therefore need make dried material particles degree even through sieving whole.
(8) compressing tablet: be dosed into tablet press machine after dry good mixing of materials is even, material is struck out circular piece, compressing tablet pressure is 4.5 * 10
3Kgf.
(9) packing: with certified tablet monolithic sealing packing on packing machine that type is complete.
In order to make solid beverage of the present invention easy to use, but need not to stir quick autolysis, easy to carry, the base-material of pick-me-up of the present invention can be the various base-materials that self-dissolving generates beverage that are suitable for.Beverage of the present invention can be a solid pharmaceutical preparation, as pulvis, granule or tablet, effervescent agent etc.; Also can be the drink liquid agent, as the aqueous solution, oral liquid etc.Preferably effervescent agent, most preferably effervescent tablet.
Three, compressing tablet end product quality specification:
1, color and luster: white or fruit look, color and luster uniformity.
2, form: round sheet, diameter 25mm, weigh 3.0 ± 0.2g, the sheet type is complete.
3, fragrance and flavour: sour and sweet palatability, different cultivars have its distinctive fruit aroma and flavour, free from extraneous odour.
4, impurity: the visible exogenous impurity of no naked eyes.
5, heavy metal index: plumbous (in Cu)≤1.0mg/kg, arsenic (in As)≤0.5mg/kg, copper (in Cu)≤10.0mg/kg.
6, microbiological indicator: total number of bacteria≤1000/g, coliform≤30/100g, pathogenic bacteria must not detect.
7, packaging material and specification: packaging material are the PET/AL/PE complex pocket, and specification is 50 * 55mm
2
8, sealing-strength: sealing-strength is not less than 3.4kgf/20mm.
9, the shelf-life: preserve at normal temperatures and never degenerated in 2 years.
Through testing checking for effect:
Product has good effect among the present invention, verifies the effect of product of the present invention below with regard to the hot exposure test of active mouse and rat.
1, the hot exposure test of mouse
Healthy male mice in kunming is divided into drinking-water group and beverage I group at random, beverage II group, every group 12, every day is in 37 ± 2 ℃ of dry-bulb temperatures, the artificial hot room of 60 ± 10% relative humidity exposes 8 hours, cut off the water supply between exposure period, give pure water (drinking-water group) to irritate the stomach mode, beverage I (beverage I group) or beverage II (beverage II group), morning and afternoon respectively once, each every 0.4ml, the formulated that beverage I (GJB1637-93) is provided according to GJB " the military work personnel's of thermal environment water salt increments ", beverage II is an anti-heatstroke effervescent beverage(s) of the present invention; Animal feed (normal feed) every box 10 grams every day are weighed once weekly.Tested the 14th day, and do not irritate stomach, the exposure of fasting heat, observed and recorded animal dead situation.
2, the hot exposure test of rat
Healthy male rat is divided into drinking-water group and beverage group at random, every group of 7-8 head, every day, the artificial hot room in 37 ± 2 ℃ of dry-bulb temperatures, 60 ± 10% relative humidity exposed 8 hours, cut off the water supply between exposure period, give pure water (drinking-water group), beverage (beverage group) to irritate the stomach mode, morning and afternoon each once, each every 2ml, beverage is anti-heatstroke effervescent beverage(s) of the present invention; Animal feed (normal feed) every day, every 8 gram was weighed once weekly.Tested in the 21st day and finish, do not irritate stomach, the exposure of fasting heat, record animal dead situation.
Measurement result
Death condition between the hot exposure period of table 1 mouse
The 3rd day death toll fortnight death toll death rate (%) of group animal (head)
Drinking-water organizes 12 36 75.0
Beverage I organizes 12 32 41.7**
Beverage II organizes 12 31 33.3**
Chi-square Test, compare with the drinking-water group * * P＜0.01.
Death condition after three week of table 2 rat, heat exposed
The group dead death rate (%) of surviving
Drinking-water organizes 25 71.4
Beverage II organizes 71 12.5
Because this beverage contains important antioxidants such as vitamin A, C, E, after result of the test shows drinking of said beverage, the product MDA of rat peripheral blood lipid peroxidation reduces, antioxidase GSHPx activity main in the body raises, so it is relevant that this beverage reduces the effect of the raising antioxidant ability of organism that effect that heat exposes the back death rate also had with this beverage.
The interior level of endotoxin of body raise and is considered to suffer heatstroke one of dead immediate cause in back after heat exposed, and normally the shielding action of enteron aisle can prevent that the interior endotoxin of enteron aisle from entering in the body, even the endotoxin of trace enters in the body, liver also can be drained its metabolism.After heat exposed, the shielding action of normal enteron aisle weakened, and liver function also descends, a large amount of endotoxins enters in the body in the enteron aisle, and the activated mononuclear macrophage discharges a large amount of inflammatory cytokines, as TNF-α, IL-1 etc., cause systemic reactions such as heating, severe patient will directly cause death.This result of the test shows the rat of drinking of said beverage, and the peripheral blood level of endotoxin significantly is lower than the rat of drinking pure water, illustrates that this beverage has the effect that endotoxin raises in the body of heat exposure back that suppresses.
The specific embodiment
The invention will be further described to utilize embodiment below:
Embodiment 1
The anti-heatstroke of technology preparation effervescent beverage(s) according to ingredient inspection → pulverizing → batching → mixing → system softwood → granulating and forming → oven dry → cooling → whole grain → compressing tablet → packing.
Wherein each component proportionally: citric acid 1500mg, natrium citricum 50mg, NaHCO
3750mg, Aspartame 300mg, essence 200mg, potassium chloride 120mg, calcium chloride 20mg, magnesium sulfate 10mg, ferric sulfate 5mg, zinc sulfate 2mg, Cobastab
10.6mg, Cobastab
20.4mg, Cobastab
60.5mg, dehydroretinol 50 μ g, vitamin E2 .5mg, Catergen 5mg, nicotinic acid 0.125mg mix.
Embodiment 2
Manufacture method is with embodiment 1, and wherein each component proportionally: citric acid 1400mg, natrium citricum 45mg, NaHCO
3600mg, Aspartame 250mg, essence 180mg, potassium chloride 115mg, calcium chloride 18mg, magnesium sulfate 8mg, ferric sulfate 2mg, zinc sulfate 1.8mg, Cobastab
10.5mg, Cobastab
20.3mg, Cobastab
60.4mg, dehydroretinol 30 μ g, vitamin E2 .3mg, Catergen 2mg, nicotinic acid 0.11mg mix.
Embodiment 3
Manufacture method is with embodiment 1, and wherein each component proportionally: citric acid 1600mg, natrium citricum 55mg, NaHCO
3900mg, Aspartame 350mg, essence 220mg, potassium chloride 125mg, calcium chloride 22mg, magnesium sulfate 12mg, ferric sulfate 5mg, zinc sulfate 2.2mg, Cobastab
10.7mg, Cobastab
20.5mg, Cobastab
60.6mg, dehydroretinol 70 μ g, vitamin E2 .7mg, Catergen 7mg, nicotinic acid 0.13mg mix.
Embodiment 4
Manufacture method is with embodiment 1, and wherein each component proportionally: citric acid 1450mg, natrium citricum 48mg, NaHCO
3750mg, Aspartame 280mg, essence 190mg, potassium chloride 118mg, calcium chloride 19mg, magnesium sulfate 9mg, ferric sulfate 4mg, zinc sulfate 1.9mg, Cobastab
10.55mg, Cobastab
20.35mg, Cobastab
60.45mg, dehydroretinol 40 μ g, vitamin E2 .4mg, Catergen 3mg, nicotinic acid 0.115mg mix.
Embodiment 5
Manufacture method is with embodiment 1, and wherein each component proportionally: citric acid 1550mg, natrium citricum 52mg, NaHCO
3850mg, Aspartame 320mg, essence 210mg, potassium chloride 122mg, calcium chloride 21mg, magnesium sulfate 11mg, ferric sulfate 6mg, zinc sulfate 2.1mg, Cobastab
10.65mg, Cobastab
20.45mg, Cobastab
60.55mg, dehydroretinol 60 μ g, vitamin E2 .6mg, Catergen 6mg, nicotinic acid 0.125mg mix.
Verified that by the hot exposure test of active mouse and rat product of the present invention has tangible anti-heatstroke effect.Because this beverage contains important antioxidants such as vitamin A, C, E, after result of the test also shows drinking of said beverage, the product MDA of rat peripheral blood lipid peroxidation reduces, antioxidase GSHPx activity main in the body raises, so the effect of the death rate was also relevant with the effect of its raising antioxidant ability of organism that is had after this beverage reduction heat exposed.This beverage need not stir and can generate liquid beverage by quick autolysis, has effectively anti-heatstroke function, and the army that is very suitable for executing the task under the thermal environment uses, but also double as is civilian simultaneously.
Claims (3)
1. effervescent beverage(s) with anti-heatstroke function, its constituent and proportioning are: citric acid 1400-1600mg, natrium citricum 45-55mg, NaHCO
3600-900mg, Aspartame 250-350mg, essence 180-220mg, potassium chloride 115-125mg, calcium chloride 18-22mg, magnesium sulfate 8-12mg, ferric sulfate 2-8mg, zinc sulfate 1.8-2.2mg, Cobastab
10.5-0.7mg, Cobastab
20.3-0.5mg, Cobastab
60.4-0.6mg, dehydroretinol 30-270 μ g, vitamin E2 .3-2.7mg, Catergen 2-27mg, nicotinic acid 0.11-0.13mg.
2. the effervescent beverage(s) with anti-heatstroke function as claimed in claim 1, its constituent and proportion optimization are: citric acid 1450-1550mg, natrium citricum 48-52mg, NaHCO
3750-850mg, Aspartame 280-320mg, essence 190-210mg, potassium chloride 118-122mg, calcium chloride 19-21mg, magnesium sulfate 9-11mg, ferric sulfate 4-6mg, zinc sulfate 1.9-2.1mg, Cobastab
10.55-0.65mg, Cobastab
20.35-0.45mg, Cobastab
60.45-0.55mg, dehydroretinol 40-260 μ g, vitamin E2 .4-2.6mg, Catergen 3-26mg, nicotinic acid 0.115-0.125mg.
3. the effervescent beverage(s) with anti-heatstroke function as claimed in claim 1, its constituent and proportioning most preferably are: citric acid 1500mg, natrium citricum 50mg, NaHCO
3750mg, Aspartame 300mg, essence 200mg, potassium chloride 120mg, calcium chloride 20mg, magnesium sulfate 10mg, ferric sulfate 5mg, zinc sulfate 2mg, Cobastab
10.6mg, Cobastab
20.4mg, Cobastab
60.5mg, dehydroretinol 50 μ g, vitamin E2 .5mg, Catergen 5mg, nicotinic acid 0.125mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021038821A CN1187040C (en) | 2002-04-05 | 2002-04-05 | Anti-heatstroke effervescent beverage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021038821A CN1187040C (en) | 2002-04-05 | 2002-04-05 | Anti-heatstroke effervescent beverage |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1449691A true CN1449691A (en) | 2003-10-22 |
| CN1187040C CN1187040C (en) | 2005-02-02 |
Family
ID=28680048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021038821A Expired - Fee Related CN1187040C (en) | 2002-04-05 | 2002-04-05 | Anti-heatstroke effervescent beverage |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1187040C (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1301109C (en) * | 2004-09-24 | 2007-02-21 | 郭凌云 | Calcium, zinc and ferrum composite oral liquor and its preparing process |
| WO2007061803A1 (en) * | 2005-11-23 | 2007-05-31 | The Coca-Cola Company | High-potency sweetener composition with c-reactive protein reducing substance and compositions sweetened therewith |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| JP2015198650A (en) * | 2014-04-03 | 2015-11-12 | 大正製薬株式会社 | beverage |
| CN109683533A (en) * | 2019-01-15 | 2019-04-26 | 佛山市顺德区美的饮水机制造有限公司 | The method for pouring and brewing device of intelligent brewing machine based on Internet of Things |
-
2002
- 2002-04-05 CN CNB021038821A patent/CN1187040C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1301109C (en) * | 2004-09-24 | 2007-02-21 | 郭凌云 | Calcium, zinc and ferrum composite oral liquor and its preparing process |
| WO2007061803A1 (en) * | 2005-11-23 | 2007-05-31 | The Coca-Cola Company | High-potency sweetener composition with c-reactive protein reducing substance and compositions sweetened therewith |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| JP2015198650A (en) * | 2014-04-03 | 2015-11-12 | 大正製薬株式会社 | beverage |
| CN109683533A (en) * | 2019-01-15 | 2019-04-26 | 佛山市顺德区美的饮水机制造有限公司 | The method for pouring and brewing device of intelligent brewing machine based on Internet of Things |
| CN109683533B (en) * | 2019-01-15 | 2022-06-14 | 佛山市顺德区美的饮水机制造有限公司 | Brewing method and brewing device of intelligent brewing machine based on Internet of things |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1187040C (en) | 2005-02-02 |
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Granted publication date: 20050202 Termination date: 20120405 |