CN1638871A - 通过离心力和/或毛细力精确输送和操作流体的方法和装置 - Google Patents
通过离心力和/或毛细力精确输送和操作流体的方法和装置 Download PDFInfo
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- CN1638871A CN1638871A CNA038046431A CN03804643A CN1638871A CN 1638871 A CN1638871 A CN 1638871A CN A038046431 A CNA038046431 A CN A038046431A CN 03804643 A CN03804643 A CN 03804643A CN 1638871 A CN1638871 A CN 1638871A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
- F04B19/006—Micropumps
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
- B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Abstract
Description
密度 | 粘度 | 表面张力10E-3N/m或dyn/cm | 冰点降低℃ | 重量克分子渗透浓度mmol/kg | pH值 | 干燥质量g/L | ||
极限范围 | 低 | 1.001 | 1 | 64 | 0.1 | 50 | 4.5 | 50 |
高 | 1.028 | 1.14 | 69 | 2.6 | 1440 | 8.2 | 72 |
试验 | 试样 | 试样中的血红蛋白 | 观察 |
1 | 条上的Hb试剂 | 1mg/dl | 蓝色 |
1 | R4中的Hb试剂 | 1mg/dl | 蓝色 |
2 | 条上的Hb试剂 | 0mg/dl | 橙色 |
2 | R4中的Hb试剂 | 0mg/dl | 橙色 |
试验 | 试样 | 试样中的血红蛋白 | 观察 |
3 | 条上的Hb试剂 | 1mg/dl | 蓝色 |
3 | R2中的Hb试剂 | 1mg/dl | 蓝色 |
4 | 条上的Hb试剂 | 0mg/dl | 橙色 |
5 | R2中的Hb试剂 | 0mg/dl | 橙色 |
试验 | 试样 | 试样中的血红蛋白 | 观察 |
3 | 条上的Alb试剂 | 1mg/dl | 蓝色 |
3 | R4中的Alb试剂 | 1mg/dl | 蓝色 |
4 | 条上的Alb试剂 | 0mg/dl | 橙色 |
5 | R4中的Alb试剂 | 0mg/dl | 橙色 |
Claims (37)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/082,415 US7459127B2 (en) | 2002-02-26 | 2002-02-26 | Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces |
US10/082,415 | 2002-02-26 | ||
PCT/IB2003/000562 WO2003072252A1 (en) | 2002-02-26 | 2003-02-17 | Method and apparatus for precise transfer and manipulation of fluids by centrifugal, and/or capillary forces |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1638871A true CN1638871A (zh) | 2005-07-13 |
CN1638871B CN1638871B (zh) | 2010-12-29 |
Family
ID=27765273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN038046431A Expired - Lifetime CN1638871B (zh) | 2002-02-26 | 2003-02-17 | 通过离心力和/或毛细力精确输送和操作流体的方法和装置 |
Country Status (9)
Country | Link |
---|---|
US (2) | US7459127B2 (zh) |
EP (1) | EP1480750A1 (zh) |
JP (1) | JP4351539B2 (zh) |
KR (1) | KR101005799B1 (zh) |
CN (1) | CN1638871B (zh) |
AU (1) | AU2003248353A1 (zh) |
CA (1) | CA2477413A1 (zh) |
HK (1) | HK1080023B (zh) |
WO (1) | WO2003072252A1 (zh) |
Cited By (10)
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CN101715552B (zh) * | 2006-11-24 | 2012-02-01 | 新加坡科技研究局 | 用于处理液滴中样品的仪器及其使用方法 |
CN102369443A (zh) * | 2009-03-31 | 2012-03-07 | 凸版印刷株式会社 | 试样分析芯片、采用该试样分析芯片的试样分析装置和试样分析方法、以及试样分析芯片的制造方法 |
CN103175782A (zh) * | 2008-02-05 | 2013-06-26 | 松下电器产业株式会社 | 分析用仪器和使用该分析用仪器的分析方法 |
CN103534030A (zh) * | 2011-03-15 | 2014-01-22 | 卡柯洛塑料技术有限公司 | 样品计量 |
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Publication number | Publication date |
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HK1080023B (zh) | 2011-10-07 |
WO2003072252A1 (en) | 2003-09-04 |
CN1638871B (zh) | 2010-12-29 |
EP1480750A1 (en) | 2004-12-01 |
CA2477413A1 (en) | 2003-09-04 |
WO2003072252A9 (en) | 2004-11-04 |
HK1080023A1 (en) | 2006-04-21 |
US20090004059A1 (en) | 2009-01-01 |
JP4351539B2 (ja) | 2009-10-28 |
KR20040105731A (ko) | 2004-12-16 |
US7459127B2 (en) | 2008-12-02 |
AU2003248353A1 (en) | 2003-09-09 |
US20030166265A1 (en) | 2003-09-04 |
JP2005518531A (ja) | 2005-06-23 |
KR101005799B1 (ko) | 2011-01-05 |
US8337775B2 (en) | 2012-12-25 |
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