CN1849102A - 用于主动脉瓣狭窄治疗中通过动脉输送的可植入式修复装置及其方法 - Google Patents

用于主动脉瓣狭窄治疗中通过动脉输送的可植入式修复装置及其方法 Download PDF

Info

Publication number
CN1849102A
CN1849102A CNA2004800256667A CN200480025666A CN1849102A CN 1849102 A CN1849102 A CN 1849102A CN A2004800256667 A CNA2004800256667 A CN A2004800256667A CN 200480025666 A CN200480025666 A CN 200480025666A CN 1849102 A CN1849102 A CN 1849102A
Authority
CN
China
Prior art keywords
prosthetic device
metal base
valve
aortic
aperture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA2004800256667A
Other languages
English (en)
Other versions
CN1849102B (zh
Inventor
埃胡德·施瓦门塔尔
约西·图瓦尔
拉斐尔·贝纳里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Ventor Technologies Ltd
Original Assignee
Ventor Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33564047&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1849102(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ventor Technologies Ltd filed Critical Ventor Technologies Ltd
Publication of CN1849102A publication Critical patent/CN1849102A/zh
Application granted granted Critical
Publication of CN1849102B publication Critical patent/CN1849102B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958—Inflatable balloons for placing stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation
    • A61F2/2436—Deployment by retracting a sheath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/97—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2002/068—Modifying the blood flow model, e.g. by diffuser or deflector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded

Abstract

所述修复装置用于病人心脏的主动脉瓣膜中治疗主动脉瓣狭窄，该修复装置具有用于通过动脉输送的压缩状态并且可以展开至用于植入的展开状态，该修复装置包括：可展开的金属基座和衬入金属基座内表面的内膜，其中金属基座构成为可以以修复装置的展开状态植入主动脉瓣膜的主动脉瓣环中。在修复装置的展开状态中，内膜伸入主动脉中并且为扩散式锥形结构，其中它的直径从其位于主动脉瓣环内的近端到其伸入主动脉中的远端逐渐增加，以至于在心脏收缩期间产生进入主动脉的非紊态血液流，同时伴有内膜远端的压力恢复。优选的是，远端包括同时植入的修复瓣膜，但是这种修复瓣膜也可以单独植入主动脉中。另外还说明了植入这种修复装置的优选方法。

Description

用于主动脉瓣狭窄治疗中通过动脉输送的 可植入式修复装置及其方法
技术领域
本发明涉及可植入式修复装置。本发明特别用于可以通过动脉输送植入病人心脏的主动脉瓣中用于治疗主动脉瓣狭窄的修复装置中，因此下面将就该应用场合说明本发明。但是，可以认识到，本发明也可以用于其它治疗，例如主动脉回流及其它瓣膜病变。本发明还涉及植入这种修复装置的方法。
背景技术
主动脉瓣狭窄是在心脏收缩期间由主动脉瓣的开放受限而引起从左心室流入主动脉的流出道阻塞。缩小的主动脉瓣开放面积(从正常的3cm2到严重病例中小于0.5cm2)导致瓣膜上的显著压降，并且正常的心脏输出和主动脉压力有以增加的心室压力为代价才能得到保持。左心室不得不产生的高压导致增加的室壁张力和心肌需氧量。适应性处理，如肥大(补偿性增加肌肉质量)允许心脏在一段时间内承受这一增加的压力负荷，但是最终泵衰竭(pumpfailure)不可避免。
在多数病例中(在年龄高于65岁的所有病人中超过90％)主动脉瓣狭窄是由最初正常瓣膜的逐步纤维化和钙化变性、高脂蛋白血症所促成的过程、动脉高血压和衰老(后天性钙化的主动脉瓣狭窄)所引起。患有严重主动脉瓣狭窄和呼吸短缺的病人的平均存活时间低于两年。因为在很大一部分病例中死亡可能突然发生，一些研究人员建议，如果是理想的手术候选人，甚至在无症状的病人中也要进行预防性手术。
在患有单独的主动脉瓣狭窄的挑选病人组中手术结果比较好。这种病人的手术死亡率大约为5％。但是，患有明显的主动脉瓣狭窄的大多数人年龄都在70多岁和80多岁。这些病人通常具有多个共病危险因素，如冠状动脉疾病、脑血管疾病、全身性动脉粥样硬化、肾衰竭或糖尿病。因此，手术死亡率和致病率很高。而且，如果用机械修复瓣膜置换钙化的主动脉瓣膜，那么就必须防止凝血以减小血栓栓塞性并发症，这将使病人承受增大的严重出血危险。生物修复瓣膜的植入在早期通常为首选，但是，因为瓣膜需要安装于其上的缝合环减小了瓣膜本身可以利用的空间，因此手术植入的生物瓣膜可能具有并非最理想的血液动力学外形。这一点对于女人会带来特别的问题，这是由于(因为较小的心脏尺寸而不得不使用的)尺寸较小的生物修复瓣膜可能导致明显的剩余流出阻塞。
因为岁数大的病人在心肺旁路的心内手术中所承受的巨大危险，包括死亡、致残性中风、呼吸及肾脏并发症，就希望使用气囊导管的狭窄瓣膜扩张为手术提供一种选择。不幸的是，因为气囊扩张的直接结果并非最理想，并且实际上在所有病人中器官狭窄的回弹会在几个星期和几个月内再次出现，因此，结果与没有经历手术的病人一样差。气囊扩张因此被认为仅仅适合于患有明显手术禁忌征候的病人或者作为“过渡过程”。
最近，类似于支架在冠状动脉中的应用，已经有人提出使用瓣膜支架以便于获得足够大的瓣膜面积并且避免弹性回弹和再次狭窄。Spencer等人(美国专利6730118)、Andersen等人(美国专利5840081)和Gabbay(PN4759758)都说明了一种特定设计的瓣膜支架，其设计用于通过动脉放置。Cribier等人在WO98/29057中说明了一种可收缩的支架，其具有通过圆周缝合与其连接的瓣膜。网/瓣膜系统经由可充气的气囊放置。在1992年，Andersen等人报道了他们对于缝合在可展开不锈钢支架中的可折叠猪主动脉瓣的经历。瓣膜支架被安装在18至22mm气囊导管上并且植入肺部位置，其中气囊导管前端装载在16F Mullins长鞘管中，完全置换肺尖(或瓣叶)，这些肺尖随着支架的完全放置而被压在支架和肺部动脉壁之间。但是，当在主动脉位置采取该方法时，这可能导致冠状动脉闭塞，而这对于病人是致命的。
即使在支架没有横过主动脉瓣环的整个面积放置时，位于二尖瓣前尖(或瓣叶)的心室一侧的动脉粥样化沉积物可能被推在冠状动脉口上，导致严重的冠状阻塞或者栓塞。为了能够放置相当大的支架而对严重钙化主动脉瓣膜的重度膨胀还可能导致瓣膜的钙沉积物的栓塞或者瓣膜的撕裂，从而导致明显的主动脉回流。此外，很大的支架一瓣膜还可能与周围结构，如二尖瓣前叶干涉(导致对其损伤或者破坏其功能)，并且如果伸入左心室流出道，就可能与室间隔基部干涉，其在明显的主动脉瓣狭窄中通常会变得肥大。
发明内容
本发明的一个目的是提供另一种修复装置，其能够通过动脉输送并且特别适用于主动脉瓣狭窄的治疗。本发明的另一个目的是提供一种修复装置，其用于植入形成于人体通道壁中的孔口中并且能够经由人体通道输送。本发明另外的目的是提供植入这种修复装置的方法。
根据本发明的一个方面，它提供了一种用于病人心脏的主动脉瓣膜中治疗主动脉瓣狭窄的修复装置，该修复装置具有用于通过动脉输送的压缩状态并且可以展开至用于植入的展开状态，该修复装置包括：可展开的金属基座和衬入金属基座内表面的内膜，其中金属基座构成为可以以修复装置的展开状态植入主动脉瓣膜的主动脉瓣环中；其特征在于，修复装置的展开状态中的内膜伸入主动脉中并且为扩散式锥形结构，其中它的直径从其位于主动脉瓣环内的近端到其伸入主动脉中的远端逐渐增加，以至于在心脏收缩期间产生进入主动脉的非紊态血液流，同时伴有塑料内膜远端的压力恢复。
因此，本发明认识到，可植入式主动脉瓣膜支架的最大孔口面积必然受限于解剖学和病理学局限性以及随后对于放置安全性的考虑。因此本发明的目的在于减小在修复装置的任何给定横截面过流面积上的永久压力损失。甚至对于尺寸相对较小的修复装置，这也允许获得合理的血液动力学外形(低压力梯度)，而对于更大的装置还优化血液动力学外形(甚至进一步降低压力梯度)。本发明因此通过使出口几何形状为流线型而实现压力恢复，以便于如文丘里(venturi)流量计那样避免紊流的产生和动能损耗。
根据所述优选实施例中的其它特征，在修复装置的展开状态中，扩散式锥形结构的内膜具有直径为5至20mm的近端和直径为15至30mm的远端，并且具有15至45mm的长度。另外，内膜的近端包括位于主动脉瓣环内部的具有同一直径的短直部分，其有效避免通过内膜的流动分离。优选的是，短直部分具有2至10mm的长度。
该装置因此可以以各种尺寸设置，以适应不同的修复尺寸(例如，12至29mm的生物修复瓣膜)以至于具有所有可能高度和人体表面积的病人都可以得到治疗。
根据本发明的另一个方面，它提供了一种修复装置，其用于植入形成于人体通道壁中的孔口中，该修复装置具有用于经由人体通道输送到植入地点的压缩状态，并且可以展开至用于植入孔口中的展开状态；该修复装置包括：构成为可以容纳在孔口中的可展开金属基座以及两个环形夹，这两个环形夹由金属基座携带并且在金属基座的展开状态中可以与壁的相对面接合用于将金属基座夹在孔口内。在所述优选实施例中，两个环形夹中每个都包括指状物的环形阵列。
如下面更具体地说明，这种结构特别适用于植入病人心脏的主动脉瓣环中，因为与需要显著扩张主动脉瓣环的修复装置相比它减小了阻塞或闭塞冠状动脉的可能性。
另外如下面更具体地说明，该修复装置还可能包括用于与金属基座一起植入的修复瓣膜；作为选择，可以在单独的手术中通过动脉输送和放置修复瓣膜。
根据本发明的另一个方面，它提供了一种方法，其用于将上述修复装置植入形成于体腔壁中的孔口中，包括：将压缩状态中的修复装置引入导管中，其中导管具有可以接合并且压缩两个环形夹的鞘管；将导管和修复装置经由人体通道输送到植入地点，使金属基座位于孔口中，并且两个环形夹位于形成有孔口的壁的相对侧；将鞘管移动到一侧释放一个环形夹使其展开，然后释放并展开另一个环形夹；并且从人体通道中取出导管和鞘管，留下植入孔口中的金属基座，而环形夹接合壁的相对侧。
根据本发明的另一个方面，它提供了另一种方法，其用于将上述修复装置植入形成于体腔壁中的孔口中，包括：将压缩状态中的修复装置引入导管中，其中导管具有可以与一个环形夹接合用于将其保持在压缩状态中的第一鞘管和可以与另一个环形夹接合用于将其保持在压缩状态中的第二鞘管；将导管和修复装置经由人体通道输送到植入地点，使金属基座位于孔口中，并且两个环形夹位于形成孔口的壁的相对侧；将第一鞘管移动到一侧以将一个环形夹释放至其展开状态；将第二鞘管移动到相对侧以将第二环形夹释放至其展开状态；并且从人体通道中取出导管和鞘管，留下植入孔口中的金属基座，而环形夹接合壁的相对侧。
因此可以看到，在两种方法中，通过环形夹与装置所植入的壁的相对面相接合而将装置植入。在两种情况下，也可能引起金属基座的少量扩张，但是其程度远远低于现有技术的气囊植入装置，其中现有技术的装置增大了阻塞或闭塞冠状动脉的危险。然而，根据所述优选实施例中的其它特征，优选的是，本发明的修复装置经由气囊导管输送，以至于稍微扩张金属基座至足以牢固接合主动脉瓣环的表面但是没有到达使其变形至增大阻塞或闭塞冠状动脉的危险的程度。
根据下面的说明将可以清楚理解本发明的其它特征和优势。
附图说明
在这里将结合附图仅仅出于示例的目的说明本发明，其中：
图1a、图1b和图1c是帮助说明由狭窄瓣膜所引起的健康问题以及由根据本发明构成的修复装置置换狭窄瓣膜口的优势的图示；
图2是显示根据本发明构成的修复装置的图示，该装置通过形成进入主动脉的非紊态血液流同时伴有修复装置远端的压力恢复来治疗上述健康问题；
图3是根据图2构成的修复装置的侧视图；
图4是三维视图，其更具体地显示了根据本发明的修复装置的一种优选结构；
图5是图4所示修复装置的侧视图；
图6是从心脏一侧观看的端视图，其显示了植入主动脉瓣环中的图4和图5所示修复装置；
图7是图4和图5所示植入的修复装置从主动脉一侧观看的透视图；
图8是不完全的详细视图，其显示了在修复装置的植入状态中环形夹接合瓣叶相对侧的方式；
图9显示了与图3中所示相似的修复装置，但是包括用于在植入时支撑修复装置远端的支架；
图10显示了被植入主动脉瓣环时图9所示修复装置；
图11显示了根据本发明的修复装置的另一种结构；
图12是三维视图，其显示了根据本发明构成的另一种修复装置；
图13是图12所示装置的侧视图；
图14显示了位于中间关闭(没有完全关闭)状态中的图12和图13所示修复装置；
图15a至图15h和图16a至图16f显示了用于植入根据本发明的两种修复装置的单鞘管法；和
图17a至图17f显示了用于植入根据本发明的修复装置的双鞘管法。
可以理解，上述附图和下面说明部分主要出于下面目的而提供，即方便对本发明的概念性特征及其各种可能的实施例，包括那些目前认为是优选的实施例的理解。为了清楚和简洁，这里并不企图提供通过常规技术和设计使本领域中的技术人员理解并且应用所述发明所需之外的更多细节。另外可以理解，所述实施例仅仅出于示例的目的，并且能够以这里所述实施例之外的其它形式和应用场合实施本发明。
具体实施方式
涉及的基本概念(图1至图3)
如上所述，本发明主要集中于将修复装置植入患病的主动脉瓣膜中用于治疗主动脉瓣狭窄。该装置设计为帮助血液压力恢复以至于降低左心室和主动脉之间的压力梯度，由此减轻心脏的工作负荷。图2示意性显示了根据本发明的修复装置的一种结构，并且图1a至图1c示意性显示了这种修复装置可以用于通过遭受明显主动脉瓣狭窄的主动脉瓣膜减轻心脏工作负荷的方式。
心血管系统中的流动调节原理与管道系统中的非常相似。主动脉压力和心脏输出由在主动脉和颈动脉中带有拉伸感受器的压力感受器系统调节。任何压力损失都将导致心脏输出的中枢诱发(centrally mediated)增加，直到再次达到预定的系统压力。
图1a因此示意性显示了从左心室LV通过主动脉口AO进入主动脉AA的血液流如何受到主动脉口AO中狭窄状况的影响。因此，这种狭窄状况明显减小了主动脉口AO的尺寸以至产生进入主动脉AA的紊流，这对进入主动脉的血压产生了很大的压力损失。这一压力损失由用于增加心室内压力的压力感受器系统检测到，由此在心室中产生增加的室壁张力，增加的心肌需氧量和最终的心脏衰竭。
如图1b中所示，当如图1a中所示的狭窄瓣膜口由具有相同狭口尺寸但是包括文丘里管结构，即具有扩散式锥形结构的修复装置置换时，就产生了进入主动脉的非紊态血液流，同时伴有装置远(宽)端的压力恢复。压力感受器系统因此将不会检测到压力损失，并因此不会增加左心室工作负荷以补偿这一压力损失。因此，将如图1a中所示的狭窄瓣膜用带有如图1b所示扩散式锥形结构的修复装置置换将减小左心室的工作负荷。
图1c示意性显示了当作用在如图1a所示的狭窄瓣膜上时和当这种瓣膜由带有如图1b所示扩散式锥形结构的修复装置置换时心脏负荷中的差别。出于示例的目的，图1c的图示是基于下面状况：心脏输出为5升/分钟；狭口的横截面面积为0.5cm2；需要的压力梯度为100mm汞柱；并且所给示例中压力感受器系统所需的主动脉压力为125。因此，在狭窄瓣膜(图1a)中产生的压头损失的显著降低将导致左心室中的血液压力在心脏收缩期间为220mm汞柱。但是，增加带有相同临界面积且具有图1b中扩散式锥形结构的修复装置将提供65mm汞柱的压力恢复，并且将在心脏收缩期间产生140mm汞柱的血液压力。实际上，压头损失从95mm汞柱降低至15mm汞柱。
图2中示意性显示的修复装置包括将要植入主动脉口AO中的具有圆形横截面的环形金属基座2、在其外端可以与主动脉瓣环中的瓣叶(尖端)的一个面接合的环形夹3和可以与瓣叶的相对面接合的另一个环形夹4。修复装置的基座末端部分2相对短直、具有同一直径，并且位于主动脉口内。修复装置的其余部分伸入主动脉AA中并且具有扩散式锥形结构，如附图标记5所示，其中它的直径从其位于心脏左心室内的近端PE到其位于主动脉内的远端DE逐渐增加。扩散式锥形部分5的锥度角(α)根据文丘里流的动力学流体原理确定，以至于产生进入主动脉的非紊态血液流，同时伴有修复装置远端的压力恢复。
因此，关于文丘里流的流体动力学众所周知，基座或狭口部分2的小直径增加了通过其中的流速，由此减小静态或横向压力；反之，扩散式锥形部分5的逐渐扩张减小流速，并由此增加静态或横向压力。这种结构产生层流或非紊态流，减小或消除扩散式锥形部分5中的流动分离，并由此减小修复装置的远端DE处的压头损失。
如下面更具体地说明，优选的是，修复装置在其远端DE带有修复瓣膜。目前可以获得几种商业上的修复性主动脉瓣膜系统，它们通常分为机械心脏瓣膜和生物心脏瓣膜。
为了适应不同尺寸和重量的病人，优选的是，展开状态中的修复装置应该具有如图3中所示的下面尺寸：近端PE的直径D1应该为5至20mm；远端DE的直径D2应该为15至30mm；从近端到远端的轴向长度L1应该为15至45mm；并且基座或狭口部分2的轴向长度L2应该为2至10mm。
狭口部分2的典型直径D1为13mm(只占成人平均流出道直径的2/3)；典型长度L2为5mm；扩散式锥形部分5的典型长度(L1-L2)为18至20mm；并且典型角度α(变宽角，与直段的偏差)为12°至25°，因为12°的角度α为层流产生几乎完全的压力恢复。例如，如果直狭口部分2具有13mm的直径(横截面面积为140mm2)，那么与该段相连并且在20mm的距离上以17°的角度α变宽的管将在其端部将具有25mm的直径(横截面面积为490mm2)。因此，尽管狭口尺寸(瓣膜内的直段)只有13mm的直径，该装置也将能够以有利的血液动力学特性在其远端(主动脉中)容纳25mm的生物修复瓣膜。
图4至图8所示的修复装置
如前所述，优选的是，根据本发明构成的修复装置在扩散式锥形部分5的远端DE还包括将要与修复装置一起植入的修复瓣膜。但是，可以预知的是，对于一些应用场合，可以不带有修复瓣膜而植入修复装置，并且在另一个随后的手术中将修复瓣膜植入修复装置下游的主动脉中。
图4至图8显示了一种包括修复瓣膜的优选修复装置结构。
因此，如图5所示截面图具体显示，所示的修复装置包括可展开的金属基座10(例如，为网状结构)以至于可以经由导管通过动脉输送到植入地点，在这种情况下，即患有主动脉瓣狭窄的主动脉瓣膜的主动脉瓣环或主动脉口。所示的修复装置还包括，例如由柔性聚合物或其它生物兼容性材料构成的内膜11，其衬入金属基座10的整个内表面。
所示修复装置的金属基座及其内衬11包括短直的狭口部分12，狭口部分12构成为植入主动脉口(图2中AO)中。修复装置还包括：与主动脉口一侧的瓣叶(尖端)的表面接合的环形夹13；与主动脉口的相对侧的瓣叶的表面接合的环形夹14；以及伸入主动脉AA中的扩散式锥形部分15。该结构使得扩散式锥形部分15从位于修复装置的近端PE的短狭口部分12到其远端DE直径逐渐增加，以便于产生通过修复装置进入主动脉的非紊态血液流，同时伴有远端的压力恢复，如上面关于图1a至图1c和图2中的图示所述。
所示修复装置的远端带有修复瓣膜16。优选的是，修复瓣膜16为由柔韧的聚合物膜构成的可收缩机械或生物瓣膜，其在心脏收缩期间有效开放修复装置的远端并且在心脏舒张期间将它关闭。例如，修复瓣膜16可以由与内衬11相同的材料构成并且沿着图5中附图标记17所示的连接线连接于此。
虽然可收缩的生物修复瓣膜为首选，但是，也可以使用其它修复瓣膜系统，如球笼式、盘笼式、倾斜盘、双叶式、止回阀等。另外可以预知，可以使用机械或合成修复瓣膜。
在所示修复装置的展开状态中，环形夹13、14每个由与主动脉瓣环相对侧的瓣叶(尖端)表面接合的指状物的环形阵列构成，如图6至图8中更具体地显示。因此，如图8中具体地显示，环形夹13包括可以与主动脉瓣环AO位于心脏左心室一侧的自体瓣叶表面18(图6)接合的指状物13a的环形阵列；并且环形夹14包括可以与主动脉瓣环位于主动脉一侧的自体瓣叶表面19(图7)接合的指状物14a的类似环形阵列。
任何合适的方法都可以用于将内膜或内衬11连接到金属基座10的内表面上。例如，这可以如下进行：通过使用长效的生物兼容性胶粘剂进行胶接；通过使用声能在塑料内膜11接触金属基座的地方将其软化而进行超声波焊接；或者通过注射模制聚合物材料以在其中嵌入金属基座。其它可能的方法包括其中将内膜机械锁定到金属基座上的机械锁定装置，或其中将内膜缝合到金属基座上的缝合技术。
如上面粗略地说明和下面更具体地说明，修复装置10构成为具有用于通过动脉输送的压缩状态并且可以展开至用于植入的展开状态。出于该目的，金属基座10，包括其扩散式锥形部分15及其环形夹13和14，可以为纯金属、金属合金或者它们的组合。内衬11可以为合适的生物兼容性聚合物或塑料材料。
可以使用的纯金属的例子包括钨、铂和钛。具有必需的物理特性的金属合金包括(但是不限于)不锈钢316和镍钛诺(镍钛)，两者都具有生物兼容性并且商业上可以获得。例如，镍钛诺可以用于环形夹13和14以及扩散式锥形部分15，而另一种传统的金属支架材料，如不锈钢316可以用于基座或狭口部分12。涤纶通常用于覆盖镍钛诺装置，但是，其它合适的生物兼容性聚合物或弹性体材料可以用于内膜或内衬11。
图9、图10和图11所示的修复装置
图9显示了一种与上面关于图4至图8所述相似的修复装置，因此为了方便理解，相应的部件由相同的附图标记表示。图9中所示修复装置的主要区别在于提供了多个支撑元件20，其由金属基座10的远端DE携带并且可以与主动脉的内表面接合用于在主动脉内部支撑修复装置，具体地说，即其远端，如图10所示。
图11显示了一种修改，其中支撑元件与由附图标记30表示的金属基座，具体地说，环形夹34的夹紧指状物34a一体形成，所述指状物可以与主动脉瓣环中瓣叶的远(主动脉)侧接合。因此，由附图标记40表示的支撑元件也是环形阵列的形式，该环形阵列从修复装置的远端，从它们与金属基座30的锥形部分35的连接点41延伸到夹紧指状物34a。夹紧指状物34a因此可以与其狭口部分32所携带的夹紧指状物33a协同作用以将装置夹在主动脉口中。支撑元件40构成为接合主动脉的内表面，优选的是，接近修复装置的远端，以便于在修复装置植入主动脉瓣环时支撑该端部。当然，关键的是，它们构成为不会阻塞或闭塞主动脉瓣环附近的冠状动脉(如下面对图16f的说明中所述)。
支撑元件40可以由与金属基座30相同的材料构成，例如，镍钛诺。出于简化的目的，图11省略了内衬和修复瓣膜，分别为图5中的附图标记11和16。
图12至图14所示的修复装置
图12至图14显示了一种与上述装置有很大差别的修复装置，其不同之处在于金属基座只占据了安装在主动脉瓣环中的修复装置的狭口部分(图2中附图标记2)；也就是说，图12至图14中由附图标记110表示的金属基座没有延伸到修复装置的扩散式锥形部分(图2中附图标记5)或者只构成其一部分。修复装置的扩散式锥形部分5(图2)只由图12至图14中的附图标记111表示的内膜占据，该塑料内膜还用作修复瓣膜。因此，在心脏收缩期间，内膜111开放并且呈现扩散式锥形结构，以至于产生进入主动脉的非紊态血液流，同时伴有内膜远端的压力恢复；反之，在心脏舒张期间，内膜111收缩以堵塞通过其中的流动。
只对应于将要植入主动脉瓣环中的修复装置的狭口部分(例如，图5中附图标记12)的金属基座110还包括两个指状物113、114的环形阵列，在其相对侧用于与主动脉瓣环中瓣叶的相对表面接合，并因此对应于图5中的环形夹13、14。
内膜111衬入金属基座110的内表面。它于是向金属基座的外部延伸以形成修复装置的扩散式锥形部分，以及由修复装置的远端携带的修复瓣膜(分别对应于图5中部分15和瓣膜16)。
内膜111还包括多个轴向延伸的支柱112，所述支柱在112a处枢轴安装到金属基座110上，以允许内膜在心脏收缩期间展开至其瓣膜开放状态以允许血液流过其中，同时呈现扩散式锥形结构，用于产生进入主动脉的非紊态血液流，同时伴有远端的压力恢复。支柱112还允许内膜111在心脏舒张期间收缩以便于有效堵塞通过其中的血液流，并且履行修复瓣膜的功能。图14显示了部分收缩状态中的内膜111。
加强支柱112可以由与金属基座110相同的金属构成，并且可以通过一体形成的铰链枢轴安装到基座上。作为选择，加强支柱112可以由不同材料构成，例如，由不同的金属或塑料构成，其足够坚硬以在心脏收缩期间在其瓣膜开放锥形结构中支撑内膜111，并且以任何合适的方式机械铰接到金属基座110上。
因此可以看到，图12至图14中所示的修复装置不仅用于调节从左心室流入主动脉的流动以产生上述进入主动脉的非紊态流，同时伴有压力恢复，而且用作在心脏收缩期间开放并且在心脏舒张期间关闭的修复瓣膜。
                      放置方法
如前所述，本发明的修复装置设计用于植入形成于人体通道壁中的狭口中。因此，它构成为具有用于经由人体通道输送到植入地点的压缩状态并且可以在植入地点展开至用于植入狭口中的展开状态。上述本发明的优选实施例设计用于植入病人心脏的主动脉瓣环中，并因此构成为通过动脉输送到主动脉瓣环并且在主动脉瓣环中展开用于植入其中。
下面将关于图15a至图15h和图16a至图16f说明单鞘管放置法；并且关于图17a至图17h说明双鞘管放置法。
单鞘管放置法
图15a至图15h示意性显示了一种使用单个鞘管放置，例如图2中所示的修复装置的方法；而图16a至图16f显示了用于放置具有如图11中所示结构，即包括支撑元件40的环形阵列的修复装置的方法。
在图15a至图15h所示的单鞘管法中，由附图标记PD一般表示并且具有图2中所示结构的修复装置将要通过环形夹3、4植入主动脉瓣膜AV的主动脉口AO中。当如此植入时，修复装置的狭口部分2被植入主动脉口AO中，并且修复装置的扩散式锥形部分5容纳在主动脉AA中。
为了将修复装置PD输送到植入地点，它被引入包括气囊201和鞘管202的导管200中。处于充气状态中的气囊201容纳修复装置的狭口部分2和两个环形夹3、4。鞘管202包围整个修复装置并且将它，包括环形夹3、4和扩散式锥形部分5保持在用于通过动脉输送的压缩状态中。
将导管引入病人的外围动脉中并且以传统方式操纵以使狭口部分2与主动脉口AO对齐，同时两个环形夹3、4位于形成孔口的瓣叶的相对侧(图15a)。
鞘管202然后移动到一侧(图15b)释放第一环形夹3使其展开(图15c)，然后释放并展开环形夹4(图15d、图15e)，并且最终释放并展开修复装置的扩散式锥形部分5(图15f)。气囊201然后充气(图15g)以将基座部分2牢固压在孔口内，然后放气(图15h)以允许导管200与气囊201和鞘管202一起从动脉中取出，留下修复装置夹在孔口内。
因为修复装置由两个环形夹3、4夹紧孔口，因此可能并非必需使用气囊；但是，这可以用于更加确保修复装置正确植入孔口内。但是，提供两个环形夹3、4使得狭口部分2能够仅仅稍微扩张，即扩张至远低于传统支架式植入的程度，并由此减小阻塞或闭塞冠状动脉的危险。
图16a至图16f显示了通过如下状态放置图11中所示修复装置(即包括支撑元件40的环形阵列)的上述单鞘管法：图16a，其中狭口部分32位于主动脉口中；图16b，其中鞘管201已经移动到一侧足以释放夹子33的指状物33a；图16c，其中鞘管的继续移动释放另一个环形夹34的指状物34a；图16d和16e，其中鞘管的继续移动开始释放修复装置的扩散式锥形部分35；和图16f，其中鞘管已经移动至足以释放并用于展开整个修复装置，包括锥形部分35和环绕锥形部分的支撑元件40。如图16f中具体地显示，支撑元件40构成为在修复装置的植入状态中不会阻塞冠状动脉CA。
虽然图16a至图16f中所示的方法没有使用可充气的气囊，但是应该认识到，也可以使用这种可充气的气囊，如上面关于图15a至图15h所述，以更加确保修复装置牢固植入主动脉口中。
双鞘管放置法
图17a至图17h显示了放置修复装置的双鞘管法。出于示例的目的，上面所述修复装置为图4至图8中所示的修复装置。
因此，在双鞘管法中，其中由附图标记300表示的导管包括位于外端用于与修复装置的环形夹13接合的第一鞘管301和从鞘管301向内延伸以至于与修复装置的环形夹14和扩散式锥形部分15接合的第二鞘管302。这是图17a中所示的状态。
首先操纵导管使修复装置的狭口部分12位于主动脉口中(图17a)。鞘管302然后横向移动到一侧(向右)以便于释放环形夹14(图17b)。当夹子已经释放时，导管然后向心脏内移动(向左)微量距离(图17c)以将环形夹14的夹紧指状物14a牢固压在瓣叶的各个表面上，以至于环形夹14牢固接合图17c中所示瓣叶的主动脉表面(图8中附图标记18)。
外部鞘管301然后背对鞘管302，即向左移动进一步进入心脏。该动作释放环形夹13至其展开状态，与瓣叶面对左心室的表面(图8中附图标记19)接触(图17d)。此时，导管300于是可以沿相反方向(向右)移动以将环形夹13的夹紧指状物13a与瓣叶的该表面牢固接合。
主动脉内部的鞘管302于是可以进一步背对鞘管301移动，由此释放修复装置的其余部分，用于展开，如图17e和图17f中所示。
如果需要，图17a至图17f中所示的导管也可以包括气囊(未示出)，以至于在主动脉口内稍微进一步扩张金属基座12，在这种情况下，然后可以将气囊放气以便于允许取出导管及其鞘管。
在上述放置方法中可以认识到，即使没有使用气囊，当取出各个鞘管时，各种修复装置的基座部分仍然将稍微扩张，以使基座部分牢固位于主动脉瓣环内并且还允许取出导管及其鞘管。但是，提供这种气囊允许另外扩张修复装置的基座部分至足以更加确保牢固植入孔口内，但是没有达到阻塞或闭塞冠状动脉的程度。
虽然已经关于几种优选实施例说明了本发明，但是应该认识到，这些仅仅是出于示例的目的而给出，并且可以对本发明进行很多其它的变化、修改和应用。

Claims (40)

1、一种修复装置，其用于病人心脏的主动脉瓣膜中治疗主动脉瓣狭窄，所述修复装置具有用于通过动脉输送的压缩状态并且可以展开至用于植入的展开状态，所述修复装置包括：
可展开的金属基座，其构成为可以以修复装置的展开状态植入主动脉瓣膜的主动脉瓣环中；和
内膜，其衬入金属基座的内表面；
其特征在于，修复装置的展开状态中的所述内膜伸入主动脉中并且为扩散式锥形结构，其中它的直径从其位于主动脉瓣环内的近端到其伸入主动脉中的远端逐渐增加，以至于在心脏收缩期间产生进入主动脉的非紊态血液流，同时伴有塑料内膜远端的压力恢复。
2、根据权利要求1所述的修复装置，其特征在于，在修复装置的展开状态中，扩散式锥形结构的所述内膜具有直径为5至20mm的近端和直径为15至30mm的远端，并且具有15至45mm的长度。
3、根据权利要求2所述的修复装置，其特征在于，内膜的所述近端包括位于所述主动脉瓣环内部的具有同一直径的短直部分，所述短直部分有效避免通过所述塑料内膜的流动分离。
4、根据权利要求3所述的修复装置，其特征在于，所述短直部分具有2至10mm的长度。
5、根据权利要求1所述的修复装置，其特征在于，病人心脏的所述主动脉瓣膜为下面类型，即包括可以移动至开放和关闭位置的多个瓣叶，并且其中所述金属基座包括两个环形夹，这两个环形夹可以与位于开放位置的所述瓣叶的相对侧接合用于将金属基座夹在所述瓣叶上。
6、根据权利要求5所述的修复装置，其特征在于，所述两个环形夹中每个都包括指状物的环形阵列。
7、根据权利要求6所述的修复装置，其特征在于，所述金属基座包括位于修复装置远端的支撑元件的环形阵列，其可以与主动脉的内表面接合用于在主动脉内部支撑修复装置。
8、根据权利要求7所述的修复装置，其特征在于，所述支撑元件在一端与所述环形夹之一的指状物的所述环形阵列一体形成。
9、根据权利要求1所述的修复装置，其特征在于，所述金属基座在修复装置的展开状态中延伸至内膜的所述远端，以至于所述内膜用作内衬，其从修复装置的所述近端至所述远端衬入金属基座的内表面。
10、根据权利要求9所述的修复装置，其特征在于，所述金属基座在修复装置的远端携带有修复瓣膜，该修复瓣膜控制从心脏进入主动脉的血液流。
11、根据权利要求10所述的修复装置，其特征在于，所述修复瓣膜包括可以移动至开放和关闭位置的多个瓣叶。
12、根据权利要求11所述的修复装置，其特征在于，修复瓣膜的所述瓣叶与衬入金属基座内表面的所述内膜为一体。
13、根据权利要求1所述的修复装置，其特征在于，所述金属基座其结构和尺寸形成为在植入时只接合主动脉瓣膜的主动脉瓣环，伸入主动脉的所述内膜在心脏收缩期间为所述扩散式锥形结构，以允许通过其中的向前血液流，但是在心脏舒张期间收缩以堵塞通过其中的反向血液流。
14、根据权利要求13所述的修复装置，其特征在于，伸入主动脉的所述内膜由柔韧性材料构成。
15、根据权利要求13所述的修复装置，其特征在于，伸入主动脉的所述内膜包括多个轴向延伸的加强支柱。
16、根据权利要求15所述的修复装置，其特征在于，所述加强支柱与所述金属基座铰链连接。
17、一种修复装置，其用于植入形成于人体通道壁中的孔口中，所述修复装置具有用于经由人体通道输送到植入地点的压缩状态，并且可以展开至用于植入所述孔口中的展开状态；所述修复装置包括：
可展开的金属基座，其构成为可以容纳在所述孔口中；和
两个环形夹，其由所述金属基座携带并且在金属基座的展开状态中可以与所述壁的相对面接合用于将所述金属基座夹在所述孔口内。
18、根据权利要求17所述的修复装置，其特征在于，所述两个环形夹中每个都包括指状物的环形阵列。
19、根据权利要求17所述的修复装置，其特征在于，所述修复装置还包括衬入所述金属基座内表面的内膜；所述内膜在修复装置的展开状态中为扩散式锥形结构，其特征在于，它的直径从其位于所述孔口内的近端到其与所述孔口间隔的远端逐渐增加。
20、根据权利要求19所述的修复装置，其特征在于，在修复装置的展开状态中，扩散式锥形结构的所述内膜具有直径为5至20mm的近端和直径为15至30mm的远端，并且具有15至45mm的长度。
21、根据权利要求20所述的修复装置，其特征在于，扩散式锥形结构的所述内膜还包括与所述近端具有相同直径并且位于其附近的短直部分。
22、根据权利要求21所述的修复装置，其特征在于，所述短直部分具有2至10mm的长度。
23、根据权利要求19所述的修复装置，其特征在于，所述金属基座在修复装置的展开状态中延伸至内膜的所述远端，以至于所述内膜用作内衬，其从修复装置的所述近端至所述远端衬入金属基座的内表面。
24、根据权利要求23所述的修复装置，其特征在于，所述孔口为病人心脏中主动脉瓣膜的主动脉瓣环；并且其中金属基座的所述远端携带有修复瓣膜，该修复瓣膜控制从心脏到主动脉的血液流。
25、根据权利要求24所述的修复装置，其特征在于，所述修复瓣膜包括可以在心脏收缩期间移动至开放位置和在心脏舒张期间移动至关闭位置的多个瓣叶。
26、根据权利要求25所述的修复装置，其特征在于，修复瓣膜的所述瓣叶与衬入金属基座内表面的所述内膜为一体。
27、根据权利要求24所述的修复装置，其特征在于，所述金属基座包括位于修复装置远端的支撑指状物的环形阵列，其可以与主动脉的内表面接合用于在主动脉内部支撑修复装置的远端。
28、根据权利要求24所述的修复装置，其特征在于，所述金属基座其结构和尺寸形成为在植入时只接合主动脉瓣膜的主动脉瓣环，伸入主动脉的所述内膜在心脏收缩期间为所述扩散式锥形结构，以允许通过其中的向前血液流，但是在心脏舒张期间收缩以堵塞通过其中的反向血液流。
29、根据权利要求28所述的修复装置，其特征在于，伸入主动脉的所述内膜由柔韧性材料构成。
30、根据权利要求29所述的修复装置，其特征在于，伸入主动脉的所述内膜包括多个轴向延伸的加强支柱。
31、根据权利要求30所述的修复装置，其特征在于，所述加强支柱与所述金属基座铰链连接。
32、根据权利要求31所述的修复装置，其特征在于，所述加强支柱由与所述金属基座相同的材料构成并且通过一体铰链枢轴连接于其上。
33、一种方法，其用于将根据权利要求17所述的修复装置植入形成于人体通道壁中的孔口中，包括：
将压缩状态中的所述修复装置引入导管中，其中导管具有可以接合并且压缩所述两个环形夹的鞘管；
将所述导管和修复装置经由所述人体通道输送到植入地点，使所述金属基座位于所述孔口中，并且所述两个环形夹位于形成有所述孔口的壁的相对侧；
将所述鞘管移动到一侧释放一个所述环形夹使其展开，然后释放并展开另一个所述环形夹；和
从所述人体通道中取出所述导管和所述鞘管，留下植入所述孔口中的金属基座，而所述环形夹接合所述壁的相对侧。
34、根据权利要求33所述的方法，其特征在于，所述修复装置在由所述鞘管保持在所述压缩状态中时被越过气囊引入所述导管中，所述气囊在取出所述鞘管之后充气以在所述孔口内扩张金属基座，所述气囊放气以从所述通道中取出导管和鞘管。
35、根据权利要求33所述的方法，其特征在于，所述孔口为病人心脏中主动脉瓣膜的主动脉瓣环。
36、根据权利要求35所述的方法，其特征在于，所述修复装置在其远端携带有修复瓣膜，该修复瓣膜控制从心脏进入主动脉的血液流。
37、一种方法，其用于将根据权利要求17所述的修复装置植入形成于人体通道壁中的孔口中，包括：
将压缩状态中的所述修复装置引入导管中，其中导管具有可以与一个所述环形夹接合用于将其保持在所述压缩状态中的第一鞘管和可以与另一个所述环形夹接合用于将其保持在所述压缩状态中的第二鞘管；
将所述导管和修复装置经由所述人体通道输送到植入地点，使金属基座位于所述孔口中，并且所述两个环形夹位于形成孔口的所述壁的相对侧；
将所述第一鞘管移动到一侧以将所述一个环形夹释放至其展开状态；
将所述第二鞘管移动到相对侧以将所述第二环形夹释放至其展开状态；和
从所述人体通道中取出所述导管和所述鞘管，留下植入所述孔口中的金属基座，而所述环形夹接合所述壁的相对侧。
38、根据权利要求37所述的方法，其特征在于，所述修复装置在由所述鞘管保持在所述压缩状态中时被越过气囊引入所述导管中，所述气囊在取出所述鞘管之后充气以将金属基座牢固压在所述孔口内，所述气囊放气以从所述通道中取出导管和鞘管。
39、根据权利要求37所述的方法，其特征在于，所述孔口为病人心脏的主动脉瓣膜的主动脉瓣环，并且包括可以移动至开放和关闭位置的瓣叶；并且其中首先展开的所述第一环形夹位于金属基座面对主动脉的一侧，并且所述第二环形夹位于金属基座面对心脏的一侧。
40、根据权利要求39所述的方法，其特征在于，所述修复装置在其远端携带有修复瓣膜，该修复瓣膜控制从心脏进入主动脉的血液流，所述修复瓣膜由所述第一鞘管压缩，通过在移动所述第二鞘管之前将第一鞘管移动到一侧而部分展开，并且通过在移动所述第二鞘管之后所述第一鞘管的进一步移动而完全展开。
CN2004800256667A 2003-07-08 2004-07-06 用于主动脉瓣狭窄治疗中通过动脉输送的可植入式修复装置及其方法 Expired - Fee Related CN1849102B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48515603P 2003-07-08 2003-07-08
US60/485,156 2003-07-08
PCT/IL2004/000601 WO2005002466A2 (en) 2003-07-08 2004-07-06 Implantable prosthetic devices particularly for transarterial delivery in the treatment of aortic stenosis, and methods of implanting such devices

Publications (2)

Publication Number Publication Date
CN1849102A true CN1849102A (zh) 2006-10-18
CN1849102B CN1849102B (zh) 2011-01-19

Family

ID=33564047

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800256667A Expired - Fee Related CN1849102B (zh) 2003-07-08 2004-07-06 用于主动脉瓣狭窄治疗中通过动脉输送的可植入式修复装置及其方法

Country Status (11)

Country Link
US (1) US7429269B2 (zh)
EP (1) EP1648339B2 (zh)
JP (1) JP4942031B2 (zh)
KR (1) KR20060112705A (zh)
CN (1) CN1849102B (zh)
AU (1) AU2004253375B2 (zh)
BR (1) BRPI0412362A (zh)
CA (1) CA2531528C (zh)
NO (1) NO20060588L (zh)
RU (1) RU2006103367A (zh)
WO (1) WO2005002466A2 (zh)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101287424B (zh) * 2004-12-30 2011-02-09 文托技术有限公司 流体流动修复装置
CN106377341A (zh) * 2016-09-29 2017-02-08 复旦大学附属中山医院 一种血流分流器
CN111134899A (zh) * 2015-02-12 2020-05-12 赫莫迪纳克斯科技有限公司 主动脉植入物
CN112933394A (zh) * 2015-09-09 2021-06-11 特兰斯迈迪茨公司 用于在离体器官护理系统中使用的主动脉插管
CN113164720A (zh) * 2018-09-19 2021-07-23 Nxt生物医疗有限责任公司 在生物结构的脉管和腔室之间建立连接和分流的方法和技术
US11844345B2 (en) 2005-06-28 2023-12-19 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US11856944B2 (en) 2011-04-14 2024-01-02 Transmedics, Inc. Organ care solution for ex-vivo machine perfusion of donor lungs
US11903381B2 (en) 2014-06-02 2024-02-20 Transmedics, Inc. Ex vivo organ care system
US11917991B2 (en) 2007-03-20 2024-03-05 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system

Families Citing this family (448)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6006134A (en) 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US8579966B2 (en) 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US8016877B2 (en) 1999-11-17 2011-09-13 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US7749245B2 (en) 2000-01-27 2010-07-06 Medtronic, Inc. Cardiac valve procedure methods and devices
DE10010074B4 (de) 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
DE10010073B4 (de) 2000-02-28 2005-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verankerung für implantierbare Herzklappenprothesen
WO2002005888A1 (en) 2000-06-30 2002-01-24 Viacor Incorporated Intravascular filter with debris entrapment mechanism
AU2001285078A1 (en) 2000-08-18 2002-03-04 Atritech, Inc. Expandable implant devices for filtering blood flow from atrial appendages
US8771302B2 (en) 2001-06-29 2014-07-08 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US7544206B2 (en) 2001-06-29 2009-06-09 Medtronic, Inc. Method and apparatus for resecting and replacing an aortic valve
US8623077B2 (en) 2001-06-29 2014-01-07 Medtronic, Inc. Apparatus for replacing a cardiac valve
FR2826863B1 (fr) 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
FR2828091B1 (fr) 2001-07-31 2003-11-21 Seguin Jacques Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
FR2828263B1 (fr) 2001-08-03 2007-05-11 Philipp Bonhoeffer Dispositif d'implantation d'un implant et procede d'implantation du dispositif
US7097659B2 (en) 2001-09-07 2006-08-29 Medtronic, Inc. Fixation band for affixing a prosthetic heart valve to tissue
US7201771B2 (en) 2001-12-27 2007-04-10 Arbor Surgical Technologies, Inc. Bioprosthetic heart valve
US8308797B2 (en) 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US8721713B2 (en) 2002-04-23 2014-05-13 Medtronic, Inc. System for implanting a replacement valve
US7959674B2 (en) 2002-07-16 2011-06-14 Medtronic, Inc. Suture locking assembly and method of use
US8551162B2 (en) 2002-12-20 2013-10-08 Medtronic, Inc. Biologically implantable prosthesis
RU2006103367A (ru) 2003-07-08 2006-06-27 Вентор Текнолоджиз Лтд. (Il) Имплантируемые протезные устройства, в частности, для трансартериальной доставки при лечении аортального стеноза и способы имплантации таких устройств
US8021421B2 (en) 2003-08-22 2011-09-20 Medtronic, Inc. Prosthesis heart valve fixturing device
US9579194B2 (en) 2003-10-06 2017-02-28 Medtronic ATS Medical, Inc. Anchoring structure with concave landing zone
US7556647B2 (en) 2003-10-08 2009-07-07 Arbor Surgical Technologies, Inc. Attachment device and methods of using the same
US7854761B2 (en) 2003-12-19 2010-12-21 Boston Scientific Scimed, Inc. Methods for venous valve replacement with a catheter
US8128681B2 (en) 2003-12-19 2012-03-06 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US20050137694A1 (en) 2003-12-23 2005-06-23 Haug Ulrich R. Methods and apparatus for endovascularly replacing a patient's heart valve
US8343213B2 (en) 2003-12-23 2013-01-01 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US9526609B2 (en) 2003-12-23 2016-12-27 Boston Scientific Scimed, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8287584B2 (en) 2005-11-14 2012-10-16 Sadra Medical, Inc. Medical implant deployment tool
US20050137687A1 (en) 2003-12-23 2005-06-23 Sadra Medical Heart valve anchor and method
US7780725B2 (en) 2004-06-16 2010-08-24 Sadra Medical, Inc. Everting heart valve
US8182528B2 (en) 2003-12-23 2012-05-22 Sadra Medical, Inc. Locking heart valve anchor
US8603160B2 (en) 2003-12-23 2013-12-10 Sadra Medical, Inc. Method of using a retrievable heart valve anchor with a sheath
US7748389B2 (en) 2003-12-23 2010-07-06 Sadra Medical, Inc. Leaflet engagement elements and methods for use thereof
US7959666B2 (en) 2003-12-23 2011-06-14 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US7329279B2 (en) 2003-12-23 2008-02-12 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
CN100589779C (zh) 2003-12-23 2010-02-17 萨德拉医学公司 可再定位的心脏瓣膜
US7445631B2 (en) 2003-12-23 2008-11-04 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a patient's heart valve
US8828078B2 (en) 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US20120041550A1 (en) 2003-12-23 2012-02-16 Sadra Medical, Inc. Methods and Apparatus for Endovascular Heart Valve Replacement Comprising Tissue Grasping Elements
US8579962B2 (en) 2003-12-23 2013-11-12 Sadra Medical, Inc. Methods and apparatus for performing valvuloplasty
US9005273B2 (en) 2003-12-23 2015-04-14 Sadra Medical, Inc. Assessing the location and performance of replacement heart valves
US7824443B2 (en) * 2003-12-23 2010-11-02 Sadra Medical, Inc. Medical implant delivery and deployment tool
US8840663B2 (en) 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
US7824442B2 (en) 2003-12-23 2010-11-02 Sadra Medical, Inc. Methods and apparatus for endovascularly replacing a heart valve
US11278398B2 (en) 2003-12-23 2022-03-22 Boston Scientific Scimed, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
ITTO20040135A1 (it) 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
WO2005087140A1 (en) 2004-03-11 2005-09-22 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
CN101052359A (zh) 2004-04-23 2007-10-10 3F医疗有限公司 可植入的人工瓣膜
US8377118B2 (en) 2004-05-05 2013-02-19 Direct Flow Medical, Inc. Unstented heart valve with formed in place support structure
US7462191B2 (en) 2004-06-30 2008-12-09 Edwards Lifesciences Pvt, Inc. Device and method for assisting in the implantation of a prosthetic valve
US7820936B2 (en) * 2004-07-02 2010-10-26 Boston Scientific Scimed, Inc. Method and apparatus for controlling and adjusting the intensity profile of a laser beam employed in a laser welder for welding polymeric and metallic components
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
FR2874813B1 (fr) * 2004-09-07 2007-06-22 Perouse Soc Par Actions Simpli Prothese valvulaire
FR2874812B1 (fr) * 2004-09-07 2007-06-15 Perouse Soc Par Actions Simpli Valve protheique interchangeable
US20060052867A1 (en) 2004-09-07 2006-03-09 Medtronic, Inc Replacement prosthetic heart valve, system and method of implant
US8562672B2 (en) 2004-11-19 2013-10-22 Medtronic, Inc. Apparatus for treatment of cardiac valves and method of its manufacture
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
US20060217794A1 (en) * 2004-12-16 2006-09-28 Carlos Ruiz Separable sheath and method for insertion of a medical device into a bodily vessel using a separable sheath
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20060173490A1 (en) 2005-02-01 2006-08-03 Boston Scientific Scimed, Inc. Filter system and method
ITTO20050074A1 (it) 2005-02-10 2006-08-11 Sorin Biomedica Cardio Srl Protesi valvola cardiaca
US7867274B2 (en) 2005-02-23 2011-01-11 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7513909B2 (en) 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
US7722666B2 (en) 2005-04-15 2010-05-25 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US7962208B2 (en) 2005-04-25 2011-06-14 Cardiac Pacemakers, Inc. Method and apparatus for pacing during revascularization
US7914569B2 (en) 2005-05-13 2011-03-29 Medtronics Corevalve Llc Heart valve prosthesis and methods of manufacture and use
DE202006020994U1 (de) 2005-05-13 2011-06-21 Medtronic Corevalve Llc Herzklappenprothese
EP2901967B1 (en) 2005-05-24 2019-10-02 Edwards Lifesciences Corporation Rapid deployment prosthetic heart valve
WO2006130505A2 (en) 2005-05-27 2006-12-07 Arbor Surgical Technologies, Inc. Gasket with collar for prosthetic heart valves and methods for using them
JP5119148B2 (ja) 2005-06-07 2013-01-16 ダイレクト フロウ メディカル、 インク． 半径方向の強度が高いステントレス大動脈弁置換
US8012198B2 (en) 2005-06-10 2011-09-06 Boston Scientific Scimed, Inc. Venous valve, system, and method
US7780723B2 (en) 2005-06-13 2010-08-24 Edwards Lifesciences Corporation Heart valve delivery system
US20060287668A1 (en) * 2005-06-16 2006-12-21 Fawzi Natalie V Apparatus and methods for intravascular embolic protection
US7712606B2 (en) 2005-09-13 2010-05-11 Sadra Medical, Inc. Two-part package for medical implant
US20080188928A1 (en) * 2005-09-16 2008-08-07 Amr Salahieh Medical device delivery sheath
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US20070078510A1 (en) 2005-09-26 2007-04-05 Ryan Timothy R Prosthetic cardiac and venous valves
US8167932B2 (en) 2005-10-18 2012-05-01 Edwards Lifesciences Corporation Heart valve delivery system with valve catheter
DE102005051849B4 (de) 2005-10-28 2010-01-21 JenaValve Technology Inc., Wilmington Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen
DE102005052628B4 (de) 2005-11-04 2014-06-05 Jenavalve Technology Inc. Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter
US8092520B2 (en) * 2005-11-10 2012-01-10 CardiAQ Technologies, Inc. Vascular prosthesis connecting stent
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US9078781B2 (en) 2006-01-11 2015-07-14 Medtronic, Inc. Sterile cover for compressible stents used in percutaneous device delivery systems
US7967857B2 (en) 2006-01-27 2011-06-28 Medtronic, Inc. Gasket with spring collar for prosthetic heart valves and methods for making and using them
EP1988851A2 (en) 2006-02-14 2008-11-12 Sadra Medical, Inc. Systems and methods for delivering a medical implant
US8075615B2 (en) 2006-03-28 2011-12-13 Medtronic, Inc. Prosthetic cardiac valve formed from pericardium material and methods of making same
US8118844B2 (en) * 2006-04-24 2012-02-21 Warsaw Orthopedic, Inc. Expandable device for insertion between anatomical structures and a procedure utilizing same
WO2007130881A2 (en) 2006-04-29 2007-11-15 Arbor Surgical Technologies, Inc. Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them
EP3241525B2 (en) * 2006-06-01 2022-06-08 Edwards Lifesciences Corporation Prosthetic insert for use with a mitral valve
US20080004696A1 (en) * 2006-06-29 2008-01-03 Valvexchange Inc. Cardiovascular valve assembly with resizable docking station
US8414643B2 (en) 2006-09-19 2013-04-09 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
US8834564B2 (en) 2006-09-19 2014-09-16 Medtronic, Inc. Sinus-engaging valve fixation member
US11304800B2 (en) 2006-09-19 2022-04-19 Medtronic Ventor Technologies Ltd. Sinus-engaging valve fixation member
EP2083901B1 (en) 2006-10-16 2017-12-27 Medtronic Ventor Technologies Ltd. Transapical delivery system with ventriculo-arterial overflow bypass
US8133213B2 (en) 2006-10-19 2012-03-13 Direct Flow Medical, Inc. Catheter guidance through a calcified aortic valve
US7935144B2 (en) 2006-10-19 2011-05-03 Direct Flow Medical, Inc. Profile reduction of valve implant
CA2764601A1 (en) * 2006-10-23 2008-05-02 Valvexchange Inc. Cardiovascular valve and assembly
CA2671514A1 (en) * 2006-11-17 2008-05-29 St. Jude Medical, Inc. Prosthetic heart valve structures and related methods
JP5593545B2 (ja) * 2006-12-06 2014-09-24 メドトロニック シーブイ ルクセンブルク エス．アー．エール．エル． 弁輪に固定された自己拡張型弁の経心尖的送達のためのシステムおよび方法
US8133270B2 (en) 2007-01-08 2012-03-13 California Institute Of Technology In-situ formation of a valve
US7967853B2 (en) 2007-02-05 2011-06-28 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
WO2008103295A2 (en) 2007-02-16 2008-08-28 Medtronic, Inc. Replacement prosthetic heart valves and methods of implantation
US20080208328A1 (en) * 2007-02-23 2008-08-28 Endovalve, Inc. Systems and Methods For Placement of Valve Prosthesis System
CN101715329B (zh) 2007-03-05 2012-11-14 恩多斯潘有限公司 多组件可膨胀式支持性分叉腔内移植物和用于使用该移植物的方法
US9138315B2 (en) 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
FR2915087B1 (fr) 2007-04-20 2021-11-26 Corevalve Inc Implant de traitement d'une valve cardiaque, en particulier d'une valve mitrale, materiel inculant cet implant et materiel de mise en place de cet implant.
EP2150210B1 (en) 2007-05-15 2016-10-12 JenaValve Technology, Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
US7604662B2 (en) * 2007-07-13 2009-10-20 Boston Scientific Scimed, Inc. Endoprostheses containing boride intermetallic phases
US8747458B2 (en) 2007-08-20 2014-06-10 Medtronic Ventor Technologies Ltd. Stent loading tool and method for use thereof
AU2008288796B2 (en) 2007-08-23 2014-03-20 Dfm, Llc Cardiovascular prosthetic valve
DE102007043830A1 (de) 2007-09-13 2009-04-02 Lozonschi, Lucian, Madison Herzklappenstent
US9532868B2 (en) * 2007-09-28 2017-01-03 St. Jude Medical, Inc. Collapsible-expandable prosthetic heart valves with structures for clamping native tissue
US10856970B2 (en) 2007-10-10 2020-12-08 Medtronic Ventor Technologies Ltd. Prosthetic heart valve for transfemoral delivery
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
US8715337B2 (en) * 2007-11-09 2014-05-06 Cook Medical Technologies Llc Aortic valve stent graft
US8486131B2 (en) 2007-12-15 2013-07-16 Endospan Ltd. Extra-vascular wrapping for treating aneurysmatic aorta in conjunction with endovascular stent-graft and methods thereof
US7892276B2 (en) 2007-12-21 2011-02-22 Boston Scientific Scimed, Inc. Valve with delayed leaflet deployment
JP5687070B2 (ja) 2008-01-24 2015-03-18 メドトロニック，インコーポレイテッド 人工心臓弁用のステント
US9393115B2 (en) 2008-01-24 2016-07-19 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
US8157852B2 (en) 2008-01-24 2012-04-17 Medtronic, Inc. Delivery systems and methods of implantation for prosthetic heart valves
WO2009094197A1 (en) 2008-01-24 2009-07-30 Medtronic, Inc. Stents for prosthetic heart valves
US9149358B2 (en) 2008-01-24 2015-10-06 Medtronic, Inc. Delivery systems for prosthetic heart valves
EP2254512B1 (en) 2008-01-24 2016-01-06 Medtronic, Inc. Markers for prosthetic heart valves
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8398704B2 (en) 2008-02-26 2013-03-19 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
US8465540B2 (en) 2008-02-26 2013-06-18 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis
US9168130B2 (en) 2008-02-26 2015-10-27 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US8317858B2 (en) 2008-02-26 2012-11-27 Jenavalve Technology, Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
WO2009108355A1 (en) 2008-02-28 2009-09-03 Medtronic, Inc. Prosthetic heart valve systems
US8696689B2 (en) 2008-03-18 2014-04-15 Medtronic Ventor Technologies Ltd. Medical suturing device and method for use thereof
US8313525B2 (en) 2008-03-18 2012-11-20 Medtronic Ventor Technologies, Ltd. Valve suturing and implantation procedures
US8430927B2 (en) 2008-04-08 2013-04-30 Medtronic, Inc. Multiple orifice implantable heart valve and methods of implantation
US8696743B2 (en) 2008-04-23 2014-04-15 Medtronic, Inc. Tissue attachment devices and methods for prosthetic heart valves
US8312825B2 (en) 2008-04-23 2012-11-20 Medtronic, Inc. Methods and apparatuses for assembly of a pericardial prosthetic heart valve
EP2119417B2 (en) 2008-05-16 2020-04-29 Sorin Group Italia S.r.l. Atraumatic prosthetic heart valve prosthesis
US8323335B2 (en) 2008-06-20 2012-12-04 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves and methods for using
JP5379853B2 (ja) * 2008-07-15 2013-12-25 セント ジュード メディカル インコーポレイテッド 軸線方向に固定する、潰れ可能かつ再膨張可能な多種症状用人工心臓弁
EP2331015A1 (en) 2008-09-12 2011-06-15 ValveXchange Inc. Valve assembly with exchangeable valve member and a tool set for exchanging the valve member
EP2358307B1 (en) 2008-09-15 2021-12-15 Medtronic Ventor Technologies Ltd. Prosthetic heart valve having identifiers for aiding in radiographic positioning
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8721714B2 (en) 2008-09-17 2014-05-13 Medtronic Corevalve Llc Delivery system for deployment of medical devices
EP2334234A4 (en) 2008-09-19 2013-03-20 Tandem Diabetes Care Inc DEVICE FOR MEASURING THE CONCENTRATION OF A SOLVED SUBSTANCE AND CORRESPONDING METHOD
EP2367505B1 (en) 2008-09-29 2020-08-12 Edwards Lifesciences CardiAQ LLC Heart valve
CA2739275C (en) 2008-10-01 2017-01-17 Impala, Inc. Delivery system for vascular implant
CN102245256B (zh) 2008-10-10 2014-07-23 萨德拉医学公司 医疗装置以及用于输送医疗装置的输送系统
US8690936B2 (en) 2008-10-10 2014-04-08 Edwards Lifesciences Corporation Expandable sheath for introducing an endovascular delivery device into a body
US8137398B2 (en) 2008-10-13 2012-03-20 Medtronic Ventor Technologies Ltd Prosthetic valve having tapered tip when compressed for delivery
US8986361B2 (en) 2008-10-17 2015-03-24 Medtronic Corevalve, Inc. Delivery system for deployment of medical devices
CA2743719C (en) 2008-11-25 2019-03-19 Edwards Lifesciences Corporation Apparatus and method for in situ expansion of prosthetic device
US8308798B2 (en) 2008-12-19 2012-11-13 Edwards Lifesciences Corporation Quick-connect prosthetic heart valve and methods
EP2201911B1 (en) 2008-12-23 2015-09-30 Sorin Group Italia S.r.l. Expandable prosthetic valve having anchoring appendages
US8052741B2 (en) * 2009-03-23 2011-11-08 Medtronic Vascular, Inc. Branch vessel prosthesis with a roll-up sealing assembly
WO2010117680A1 (en) 2009-03-30 2010-10-14 Cardiovantage Medical, Inc. Sutureless valve prostheses and devices and methods for delivery
CA2961053C (en) 2009-04-15 2019-04-30 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US8512397B2 (en) 2009-04-27 2013-08-20 Sorin Group Italia S.R.L. Prosthetic vascular conduit
US8468667B2 (en) 2009-05-15 2013-06-25 Jenavalve Technology, Inc. Device for compressing a stent
WO2010150208A2 (en) 2009-06-23 2010-12-29 Endospan Ltd. Vascular prostheses for treating aneurysms
US8348998B2 (en) 2009-06-26 2013-01-08 Edwards Lifesciences Corporation Unitary quick connect prosthetic heart valve and deployment system and methods
US8979892B2 (en) 2009-07-09 2015-03-17 Endospan Ltd. Apparatus for closure of a lumen and methods of using the same
WO2011014704A2 (en) 2009-07-30 2011-02-03 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US20110313515A1 (en) 2010-06-21 2011-12-22 Arshad Quadri Replacement heart valve
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
CN102740807B (zh) 2009-11-30 2015-11-25 恩多斯潘有限公司 用于植入到具有多个分支的血管中的多部件覆膜支架系统
US8449599B2 (en) 2009-12-04 2013-05-28 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
WO2011070576A1 (en) 2009-12-08 2011-06-16 Endospan Ltd. Endovascular stent-graft system with fenestrated and crossing stent-grafts
WO2011072084A2 (en) 2009-12-08 2011-06-16 Avalon Medical Ltd. Device and system for transcatheter mitral valve replacement
WO2011080738A1 (en) 2009-12-31 2011-07-07 Endospan Ltd. Endovascular flow direction indicator
WO2011095979A1 (en) 2010-02-08 2011-08-11 Endospan Ltd. Thermal energy application for prevention and management of endoleaks in stent-grafts
US9522062B2 (en) 2010-02-24 2016-12-20 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US9226826B2 (en) 2010-02-24 2016-01-05 Medtronic, Inc. Transcatheter valve structure and methods for valve delivery
SG186837A1 (en) 2010-03-01 2013-02-28 Colibri Heart Valve Llc Percutaneously deliverable heart valve and methods associated therewith
WO2011109813A2 (en) 2010-03-05 2011-09-09 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
WO2011111047A2 (en) 2010-03-10 2011-09-15 Mitraltech Ltd. Prosthetic mitral valve with tissue anchors
US8652204B2 (en) 2010-04-01 2014-02-18 Medtronic, Inc. Transcatheter valve with torsion spring fixation and related systems and methods
US8579963B2 (en) 2010-04-13 2013-11-12 Medtronic, Inc. Transcatheter prosthetic heart valve delivery device with stability tube and method
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
CN102883684B (zh) 2010-05-10 2015-04-08 爱德华兹生命科学公司 人工心脏瓣膜
US9603708B2 (en) 2010-05-19 2017-03-28 Dfm, Llc Low crossing profile delivery catheter for cardiovascular prosthetic implant
US11278406B2 (en) 2010-05-20 2022-03-22 Jenavalve Technology, Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
IT1400327B1 (it) 2010-05-21 2013-05-24 Sorin Biomedica Cardio Srl Dispositivo di supporto per protesi valvolari e corrispondente corredo.
JP2013526388A (ja) 2010-05-25 2013-06-24 イエナバルブ テクノロジー インク 人工心臓弁、及び人工心臓弁とステントを備える経カテーテル搬送体内プロテーゼ
AU2011276503B2 (en) 2010-06-28 2015-09-17 Colibri Heart Value LLC Method and apparatus for the endoluminal delivery of intravascular devices
JP5848345B2 (ja) 2010-07-09 2016-01-27 ハイライフ エスエーエス 経カテーテル式房室弁人工器官
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US9132009B2 (en) 2010-07-21 2015-09-15 Mitraltech Ltd. Guide wires with commissural anchors to advance a prosthetic valve
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8992604B2 (en) 2010-07-21 2015-03-31 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2012012761A2 (en) 2010-07-23 2012-01-26 Edwards Lifesciences Corporation Retaining mechanisms for prosthetic valves
US9918833B2 (en) 2010-09-01 2018-03-20 Medtronic Vascular Galway Prosthetic valve support structure
CN106073946B (zh) 2010-09-10 2022-01-04 西美蒂斯股份公司 瓣膜置换装置、用于瓣膜置换装置的递送装置以及瓣膜置换装置的生产方法
US9370418B2 (en) 2010-09-10 2016-06-21 Edwards Lifesciences Corporation Rapidly deployable surgical heart valves
US9125741B2 (en) 2010-09-10 2015-09-08 Edwards Lifesciences Corporation Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves
US8641757B2 (en) 2010-09-10 2014-02-04 Edwards Lifesciences Corporation Systems for rapidly deploying surgical heart valves
WO2012040655A2 (en) 2010-09-23 2012-03-29 Cardiaq Valve Technologies, Inc. Replacement heart valves, delivery devices and methods
US8845720B2 (en) 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
US20120116496A1 (en) 2010-11-05 2012-05-10 Chuter Timothy A Stent structures for use with valve replacements
SG10201601962WA (en) 2010-12-14 2016-04-28 Colibri Heart Valve Llc Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets
US9579197B2 (en) 2010-12-15 2017-02-28 Medtronic Vascular, Inc. Systems and methods for positioning a heart valve using visual markers
CA2822381C (en) 2010-12-23 2019-04-02 Foundry Newco Xii, Inc. System for mitral valve repair and replacement
EP2579810A4 (en) 2011-02-03 2014-07-30 Endospan Ltd IMPLANTABLE MEDICAL DEVICES MANUFACTURED FROM A FORMAT MATERIAL
EP2486894B1 (en) 2011-02-14 2021-06-09 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
EP2486893B1 (en) 2011-02-14 2017-07-05 Sorin Group Italia S.r.l. Sutureless anchoring device for cardiac valve prostheses
US9855046B2 (en) 2011-02-17 2018-01-02 Endospan Ltd. Vascular bands and delivery systems therefor
EP2680788A4 (en) 2011-03-02 2014-12-10 Endospan Ltd OUTER RING WITH REDUCED VOLTAGE FOR THE TREATMENT OF AORTIC ANATOMY
EP2688516B1 (en) 2011-03-21 2022-08-17 Cephea Valve Technologies, Inc. Disk-based valve apparatus
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
EP2520251A1 (en) 2011-05-05 2012-11-07 Symetis SA Method and Apparatus for Compressing Stent-Valves
US8574287B2 (en) 2011-06-14 2013-11-05 Endospan Ltd. Stents incorporating a plurality of strain-distribution locations
CN107496054B (zh) 2011-06-21 2020-03-03 托尔福公司 人工心脏瓣膜装置及相关系统和方法
ES2568377T3 (es) 2011-06-21 2016-04-28 Endospan Ltd Sistema endovascular con endoprótesis que solapan circunferencialmente
EP2729095B1 (en) 2011-07-07 2016-10-26 Endospan Ltd. Stent fixation with reduced plastic deformation
CA2835893C (en) 2011-07-12 2019-03-19 Boston Scientific Scimed, Inc. Coupling system for medical devices
US20140324164A1 (en) 2011-08-05 2014-10-30 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
WO2013021374A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
WO2013021375A2 (en) 2011-08-05 2013-02-14 Mitraltech Ltd. Percutaneous mitral valve replacement and sealing
US8852272B2 (en) * 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
EP4289398A3 (en) 2011-08-11 2024-03-13 Tendyne Holdings, Inc. Improvements for prosthetic valves and related inventions
US9839510B2 (en) 2011-08-28 2017-12-12 Endospan Ltd. Stent-grafts with post-deployment variable radial displacement
EP3943047B1 (en) 2011-10-19 2023-08-30 Twelve, Inc. Device for heart valve replacement
US11202704B2 (en) 2011-10-19 2021-12-21 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
CN111000663B (zh) 2011-10-19 2022-04-15 托尔福公司 人工心脏瓣膜装置、人工二尖瓣和相关系统及方法
US9655722B2 (en) 2011-10-19 2017-05-23 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9039757B2 (en) 2011-10-19 2015-05-26 Twelve, Inc. Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
US9763780B2 (en) 2011-10-19 2017-09-19 Twelve, Inc. Devices, systems and methods for heart valve replacement
EP2768432A1 (en) 2011-10-21 2014-08-27 JenaValve Technology Inc. Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect
WO2013065040A1 (en) 2011-10-30 2013-05-10 Endospan Ltd. Triple-collar stent-graft
US9131926B2 (en) 2011-11-10 2015-09-15 Boston Scientific Scimed, Inc. Direct connect flush system
US8940014B2 (en) 2011-11-15 2015-01-27 Boston Scientific Scimed, Inc. Bond between components of a medical device
US8951243B2 (en) 2011-12-03 2015-02-10 Boston Scientific Scimed, Inc. Medical device handle
EP2785277B1 (en) 2011-12-04 2017-04-05 Endospan Ltd. Branched stent-graft system
US9827092B2 (en) 2011-12-16 2017-11-28 Tendyne Holdings, Inc. Tethers for prosthetic mitral valve
US9277993B2 (en) 2011-12-20 2016-03-08 Boston Scientific Scimed, Inc. Medical device delivery systems
US9510945B2 (en) 2011-12-20 2016-12-06 Boston Scientific Scimed Inc. Medical device handle
US9078747B2 (en) 2011-12-21 2015-07-14 Edwards Lifesciences Corporation Anchoring device for replacing or repairing a heart valve
EP2609893B1 (en) 2011-12-29 2014-09-03 Sorin Group Italia S.r.l. A kit for implanting prosthetic vascular conduits
US10172708B2 (en) 2012-01-25 2019-01-08 Boston Scientific Scimed, Inc. Valve assembly with a bioabsorbable gasket and a replaceable valve implant
US9579198B2 (en) 2012-03-01 2017-02-28 Twelve, Inc. Hydraulic delivery systems for prosthetic heart valve devices and associated methods
US9414823B2 (en) * 2012-04-25 2016-08-16 Medtronic Ventor Technologies Ltd. Hole-closure device
US9445897B2 (en) 2012-05-01 2016-09-20 Direct Flow Medical, Inc. Prosthetic implant delivery device with introducer catheter
US9770350B2 (en) 2012-05-15 2017-09-26 Endospan Ltd. Stent-graft with fixation elements that are radially confined for delivery
US9878127B2 (en) 2012-05-16 2018-01-30 Jenavalve Technology, Inc. Catheter delivery system for heart valve prosthesis
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9883941B2 (en) 2012-06-19 2018-02-06 Boston Scientific Scimed, Inc. Replacement heart valve
WO2014022124A1 (en) 2012-07-28 2014-02-06 Tendyne Holdings, Inc. Improved multi-component designs for heart valve retrieval device, sealing structures and stent assembly
US9675454B2 (en) 2012-07-30 2017-06-13 Tendyne Holdings, Inc. Delivery systems and methods for transcatheter prosthetic valves
US9510946B2 (en) 2012-09-06 2016-12-06 Edwards Lifesciences Corporation Heart valve sealing devices
US8628571B1 (en) 2012-11-13 2014-01-14 Mitraltech Ltd. Percutaneously-deliverable mechanical valve
ES2931210T3 (es) 2012-11-21 2022-12-27 Edwards Lifesciences Corp Mecanismos de retención para válvulas cardiacas protésicas
WO2014108895A2 (en) 2013-01-08 2014-07-17 Endospan Ltd. Minimization of stent-graft migration during implantation
EP2948103B1 (en) 2013-01-24 2022-12-07 Cardiovalve Ltd Ventricularly-anchored prosthetic valves
US9439763B2 (en) 2013-02-04 2016-09-13 Edwards Lifesciences Corporation Prosthetic valve for replacing mitral valve
US10583002B2 (en) 2013-03-11 2020-03-10 Neovasc Tiara Inc. Prosthetic valve with anti-pivoting mechanism
US9668892B2 (en) 2013-03-11 2017-06-06 Endospan Ltd. Multi-component stent-graft system for aortic dissections
US20140277427A1 (en) 2013-03-14 2014-09-18 Cardiaq Valve Technologies, Inc. Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
CN105263443B (zh) 2013-03-14 2017-11-14 心肺医疗股份有限公司 无缝线瓣膜假体递送装置及其使用方法
US11259923B2 (en) 2013-03-14 2022-03-01 Jc Medical, Inc. Methods and devices for delivery of a prosthetic valve
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
CA2905422A1 (en) 2013-03-14 2014-10-02 Cardiovantage Medical, Inc. Embolic protection devices and methods of use
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US11406497B2 (en) 2013-03-14 2022-08-09 Jc Medical, Inc. Heart valve prosthesis
KR20220104302A (ko) 2013-03-15 2022-07-26 네비게이트 카디악 스트럭쳐스, 인크. 카테터 안내된 치환 판막 장치 및 방법
WO2014144247A1 (en) 2013-03-15 2014-09-18 Arash Kheradvar Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
US9421329B2 (en) 2013-03-15 2016-08-23 Tandem Diabetes Care, Inc. Infusion device occlusion detection system
US11224510B2 (en) 2013-04-02 2022-01-18 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US10463489B2 (en) 2013-04-02 2019-11-05 Tendyne Holdings, Inc. Prosthetic heart valve and systems and methods for delivering the same
US9486306B2 (en) 2013-04-02 2016-11-08 Tendyne Holdings, Inc. Inflatable annular sealing device for prosthetic mitral valve
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10478293B2 (en) 2013-04-04 2019-11-19 Tendyne Holdings, Inc. Retrieval and repositioning system for prosthetic heart valve
EP2991586A1 (en) 2013-05-03 2016-03-09 Medtronic Inc. Valve delivery tool
GB2514135B (en) * 2013-05-14 2015-04-15 Cook Medical Technologies Llc Implantable flow diverter
CN108294846A (zh) 2013-05-20 2018-07-20 托尔福公司 可植入心脏瓣膜装置、二尖瓣修复装置以及相关系统和方法
US9610159B2 (en) 2013-05-30 2017-04-04 Tendyne Holdings, Inc. Structural members for prosthetic mitral valves
US9468527B2 (en) 2013-06-12 2016-10-18 Edwards Lifesciences Corporation Cardiac implant with integrated suture fasteners
JP6461122B2 (ja) 2013-06-25 2019-01-30 テンダイン ホールディングス，インコーポレイテッド 人工心臓弁の血栓管理及び構造コンプライアンス特徴
US8870948B1 (en) 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
EP3016595B1 (en) 2013-07-26 2018-12-19 Edwards Lifesciences CardiAQ LLC Systems for sealing openings in an anatomical wall
EP3027144B1 (en) 2013-08-01 2017-11-08 Tendyne Holdings, Inc. Epicardial anchor devices
US9919137B2 (en) 2013-08-28 2018-03-20 Edwards Lifesciences Corporation Integrated balloon catheter inflation system
CN105491978A (zh) 2013-08-30 2016-04-13 耶拿阀门科技股份有限公司 用于假体瓣膜的径向可折叠框架及其制造方法
US10195028B2 (en) 2013-09-10 2019-02-05 Edwards Lifesciences Corporation Magnetic retaining mechanisms for prosthetic valves
WO2015058039A1 (en) 2013-10-17 2015-04-23 Robert Vidlund Apparatus and methods for alignment and deployment of intracardiac devices
EP3656353A1 (en) 2013-10-28 2020-05-27 Tendyne Holdings, Inc. Prosthetic heart valve and systems for delivering the same
US9526611B2 (en) 2013-10-29 2016-12-27 Tendyne Holdings, Inc. Apparatus and methods for delivery of transcatheter prosthetic valves
WO2015075708A1 (en) 2013-11-19 2015-05-28 Endospan Ltd. Stent system with radial-expansion locking
WO2015120122A2 (en) 2014-02-05 2015-08-13 Robert Vidlund Apparatus and methods for transfemoral delivery of prosthetic mitral valve
US9986993B2 (en) 2014-02-11 2018-06-05 Tendyne Holdings, Inc. Adjustable tether and epicardial pad system for prosthetic heart valve
WO2015127283A1 (en) 2014-02-21 2015-08-27 Cardiaq Valve Technologies, Inc. Delivery device for controlled deployement of a replacement valve
USD755384S1 (en) 2014-03-05 2016-05-03 Edwards Lifesciences Cardiaq Llc Stent
AU2015229708B2 (en) 2014-03-10 2019-08-15 Tendyne Holdings, Inc. Devices and methods for positioning and monitoring tether load for prosthetic mitral valve
US9585752B2 (en) 2014-04-30 2017-03-07 Edwards Lifesciences Corporation Holder and deployment system for surgical heart valves
WO2015179423A1 (en) 2014-05-19 2015-11-26 Cardiaq Valve Technologies, Inc. Replacement mitral valve with annular flap
US9532870B2 (en) 2014-06-06 2017-01-03 Edwards Lifesciences Corporation Prosthetic valve for replacing a mitral valve
US10195026B2 (en) 2014-07-22 2019-02-05 Edwards Lifesciences Corporation Mitral valve anchoring
EP4066786A1 (en) 2014-07-30 2022-10-05 Cardiovalve Ltd. Articulatable prosthetic valve
US10058424B2 (en) 2014-08-21 2018-08-28 Edwards Lifesciences Corporation Dual-flange prosthetic valve frame
US9901445B2 (en) 2014-11-21 2018-02-27 Boston Scientific Scimed, Inc. Valve locking mechanism
EP3028668A1 (en) * 2014-12-05 2016-06-08 Nvt Ag Prosthetic heart valve system and delivery system therefor
US9439757B2 (en) 2014-12-09 2016-09-13 Cephea Valve Technologies, Inc. Replacement cardiac valves and methods of use and manufacture
EP3068339B1 (en) 2014-12-18 2017-11-01 Endospan Ltd. Endovascular stent-graft with fatigue-resistant lateral tube
EP3242630A2 (en) 2015-01-07 2017-11-15 Tendyne Holdings, Inc. Prosthetic mitral valves and apparatus and methods for delivery of same
WO2016115375A1 (en) 2015-01-16 2016-07-21 Boston Scientific Scimed, Inc. Displacement based lock and release mechanism
US9861477B2 (en) 2015-01-26 2018-01-09 Boston Scientific Scimed Inc. Prosthetic heart valve square leaflet-leaflet stitch
US9788942B2 (en) 2015-02-03 2017-10-17 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
WO2016126524A1 (en) 2015-02-03 2016-08-11 Boston Scientific Scimed, Inc. Prosthetic heart valve having tubular seal
CA2975294A1 (en) 2015-02-05 2016-08-11 Tendyne Holdings, Inc. Expandable epicardial pads and devices and methods for delivery of same
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
EP3253333B1 (en) 2015-02-05 2024-04-03 Cardiovalve Ltd Prosthetic valve with axially-sliding frames
US10426617B2 (en) 2015-03-06 2019-10-01 Boston Scientific Scimed, Inc. Low profile valve locking mechanism and commissure assembly
US10285809B2 (en) 2015-03-06 2019-05-14 Boston Scientific Scimed Inc. TAVI anchoring assist device
US10080652B2 (en) 2015-03-13 2018-09-25 Boston Scientific Scimed, Inc. Prosthetic heart valve having an improved tubular seal
CA2983002C (en) 2015-04-16 2023-07-04 Tendyne Holdings, Inc. Apparatus and methods for delivery, repositioning, and retrieval of transcatheter prosthetic valves
US10064718B2 (en) 2015-04-16 2018-09-04 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10010417B2 (en) 2015-04-16 2018-07-03 Edwards Lifesciences Corporation Low-profile prosthetic heart valve for replacing a mitral valve
US10441416B2 (en) 2015-04-21 2019-10-15 Edwards Lifesciences Corporation Percutaneous mitral valve replacement device
US10376363B2 (en) 2015-04-30 2019-08-13 Edwards Lifesciences Cardiaq Llc Replacement mitral valve, delivery system for replacement mitral valve and methods of use
US10709555B2 (en) 2015-05-01 2020-07-14 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
WO2016183526A1 (en) 2015-05-14 2016-11-17 Cephea Valve Technologies, Inc. Replacement mitral valves
EP3294220B1 (en) 2015-05-14 2023-12-06 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
CA2990872C (en) 2015-06-22 2022-03-22 Edwards Lifescience Cardiaq Llc Actively controllable heart valve implant and methods of controlling same
US10092400B2 (en) 2015-06-23 2018-10-09 Edwards Lifesciences Cardiaq Llc Systems and methods for anchoring and sealing a prosthetic heart valve
WO2017004377A1 (en) 2015-07-02 2017-01-05 Boston Scientific Scimed, Inc. Adjustable nosecone
CR20170597A (es) 2015-07-02 2018-04-20 Edwards Lifesciences Corp Válvulas cardíacas hibridas integradas
US10195392B2 (en) 2015-07-02 2019-02-05 Boston Scientific Scimed, Inc. Clip-on catheter
WO2017004369A1 (en) 2015-07-02 2017-01-05 Edwards Lifesciences Corporation Hybrid heart valves adapted for post-implant expansion
US10179041B2 (en) 2015-08-12 2019-01-15 Boston Scientific Scimed Icn. Pinless release mechanism
US10136991B2 (en) 2015-08-12 2018-11-27 Boston Scientific Scimed Inc. Replacement heart valve implant
EP3337428A1 (en) 2015-08-21 2018-06-27 Twelve Inc. Implantable heart valve devices, mitral valve repair devices and associated systems and methods
US10117744B2 (en) 2015-08-26 2018-11-06 Edwards Lifesciences Cardiaq Llc Replacement heart valves and methods of delivery
US10575951B2 (en) 2015-08-26 2020-03-03 Edwards Lifesciences Cardiaq Llc Delivery device and methods of use for transapical delivery of replacement mitral valve
US10350066B2 (en) 2015-08-28 2019-07-16 Edwards Lifesciences Cardiaq Llc Steerable delivery system for replacement mitral valve and methods of use
EP3344158B1 (en) 2015-09-02 2023-03-01 Edwards Lifesciences Corporation Spacer for securing a transcatheter valve to a bioprosthetic cardiac structure
US10779940B2 (en) 2015-09-03 2020-09-22 Boston Scientific Scimed, Inc. Medical device handle
US10327894B2 (en) 2015-09-18 2019-06-25 Tendyne Holdings, Inc. Methods for delivery of prosthetic mitral valves
US10376364B2 (en) 2015-11-10 2019-08-13 Edwards Lifesciences Corporation Implant delivery capsule
US10470876B2 (en) 2015-11-10 2019-11-12 Edwards Lifesciences Corporation Transcatheter heart valve for replacing natural mitral valve
ES2777609T3 (es) 2015-12-03 2020-08-05 Tendyne Holdings Inc Características del marco para válvulas mitrales protésicas
CN108366859B (zh) 2015-12-28 2021-02-05 坦迪尼控股股份有限公司 用于假体心脏瓣膜的心房囊袋闭合件
US10433952B2 (en) 2016-01-29 2019-10-08 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US10342660B2 (en) 2016-02-02 2019-07-09 Boston Scientific Inc. Tensioned sheathing aids
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
USD815744S1 (en) 2016-04-28 2018-04-17 Edwards Lifesciences Cardiaq Llc Valve frame for a delivery system
WO2017189276A1 (en) 2016-04-29 2017-11-02 Medtronic Vascular Inc. Prosthetic heart valve devices with tethered anchors and associated systems and methods
US10470877B2 (en) 2016-05-03 2019-11-12 Tendyne Holdings, Inc. Apparatus and methods for anterior valve leaflet management
EP3454795B1 (en) 2016-05-13 2023-01-11 JenaValve Technology, Inc. Heart valve prosthesis delivery system for delivery of heart valve prosthesis with introducer sheath and loading system
US10583005B2 (en) 2016-05-13 2020-03-10 Boston Scientific Scimed, Inc. Medical device handle
US10245136B2 (en) 2016-05-13 2019-04-02 Boston Scientific Scimed Inc. Containment vessel with implant sheathing guide
US10456245B2 (en) 2016-05-16 2019-10-29 Edwards Lifesciences Corporation System and method for applying material to a stent
US10201416B2 (en) 2016-05-16 2019-02-12 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets
EP3468480B1 (en) 2016-06-13 2023-01-11 Tendyne Holdings, Inc. Sequential delivery of two-part prosthetic mitral valve
US11331187B2 (en) 2016-06-17 2022-05-17 Cephea Valve Technologies, Inc. Cardiac valve delivery devices and systems
WO2018005779A1 (en) 2016-06-30 2018-01-04 Tegels Zachary J Prosthetic heart valves and apparatus and methods for delivery of same
US11065116B2 (en) 2016-07-12 2021-07-20 Tendyne Holdings, Inc. Apparatus and methods for trans-septal retrieval of prosthetic heart valves
CN114587712A (zh) 2016-08-10 2022-06-07 卡迪尔维尔福股份有限公司 具有同轴框架的人工瓣膜
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
WO2018029688A1 (en) 2016-08-12 2018-02-15 Hemodynamx-Technologies Ltd Aortic implant
WO2018035375A1 (en) 2016-08-19 2018-02-22 Edwards Lifesciences Corporation Steerable delivery system for replacement mitral valve and methods of use
DK3503848T3 (da) 2016-08-26 2021-11-15 Edwards Lifesciences Corp Erstatningshjerteklapprotese i flere dele
US10758348B2 (en) 2016-11-02 2020-09-01 Edwards Lifesciences Corporation Supra and sub-annular mitral valve delivery system
FR3058631B1 (fr) * 2016-11-14 2019-01-25 Laboratoires Invalv Implant de traitement d'une valve biologique
AU2017361296B2 (en) 2016-11-21 2022-09-29 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
USD846122S1 (en) 2016-12-16 2019-04-16 Edwards Lifesciences Corporation Heart valve sizer
CR20190381A (es) 2017-01-23 2019-09-27 Cephea Valve Tech Inc Valvulas mitrales de reemplazo
AU2018203053B2 (en) 2017-01-23 2020-03-05 Cephea Valve Technologies, Inc. Replacement mitral valves
CN110392557A (zh) 2017-01-27 2019-10-29 耶拿阀门科技股份有限公司 心脏瓣膜模拟
US10433961B2 (en) 2017-04-18 2019-10-08 Twelve, Inc. Delivery systems with tethers for prosthetic heart valve devices and associated methods
US10575950B2 (en) 2017-04-18 2020-03-03 Twelve, Inc. Hydraulic systems for delivering prosthetic heart valve devices and associated methods
US10702378B2 (en) 2017-04-18 2020-07-07 Twelve, Inc. Prosthetic heart valve device and associated systems and methods
US10792151B2 (en) 2017-05-11 2020-10-06 Twelve, Inc. Delivery systems for delivering prosthetic heart valve devices and associated methods
US10646338B2 (en) 2017-06-02 2020-05-12 Twelve, Inc. Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods
US10709591B2 (en) 2017-06-06 2020-07-14 Twelve, Inc. Crimping device and method for loading stents and prosthetic heart valves
EP3634311A1 (en) 2017-06-08 2020-04-15 Boston Scientific Scimed, Inc. Heart valve implant commissure support structure
US10729541B2 (en) 2017-07-06 2020-08-04 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10786352B2 (en) 2017-07-06 2020-09-29 Twelve, Inc. Prosthetic heart valve devices and associated systems and methods
US10813757B2 (en) 2017-07-06 2020-10-27 Edwards Lifesciences Corporation Steerable rail delivery system
WO2019014473A1 (en) 2017-07-13 2019-01-17 Tendyne Holdings, Inc. PROSTHETIC CARDIAC VALVES AND ASSOCIATED APPARATUS AND METHODS FOR IMPLEMENTING THE SAME
EP3661458A1 (en) 2017-08-01 2020-06-10 Boston Scientific Scimed, Inc. Medical implant locking mechanism
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US10537426B2 (en) 2017-08-03 2020-01-21 Cardiovalve Ltd. Prosthetic heart valve
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
EP3668449A1 (en) 2017-08-16 2020-06-24 Boston Scientific Scimed, Inc. Replacement heart valve commissure assembly
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
JP7291124B2 (ja) 2017-08-28 2023-06-14 テンダイン ホールディングス，インコーポレイテッド テザー連結部を有する人工心臓弁
WO2019051476A1 (en) 2017-09-11 2019-03-14 Incubar, LLC SEALING DEVICE FOR USE AS A VASCULAR DUCT IMPLANT FOR REDUCING ENDOFUCTION
US11207200B2 (en) 2017-11-15 2021-12-28 Hemodynamx-Technologies Ltd. Aortic pressure loss reduction apparatus and methods
GB201720803D0 (en) 2017-12-13 2018-01-24 Mitraltech Ltd Prosthetic Valve and delivery tool therefor
CA3081357A1 (en) 2018-01-07 2019-07-11 Suzhou Jiecheng Medical Technology Co., Ltd. Prosthetic heart valve delivery system
CN117796968A (zh) 2018-01-07 2024-04-02 苏州杰成医疗科技有限公司 瓣膜假体
GB201800399D0 (en) 2018-01-10 2018-02-21 Mitraltech Ltd Temperature-control during crimping of an implant
JP7055882B2 (ja) 2018-01-19 2022-04-18 ボストン サイエンティフィック サイムド，インコーポレイテッド トランスカテーテル弁システム用誘導モード留置センサ
WO2019144071A1 (en) 2018-01-19 2019-07-25 Boston Scientific Scimed, Inc. Medical device delivery system with feedback loop
CN111565678B (zh) 2018-01-23 2023-07-07 爱德华兹生命科学公司 假体瓣膜保持器、系统和方法
EP3720390A2 (en) 2018-01-25 2020-10-14 Edwards Lifesciences Corporation Delivery system for aided replacement valve recapture and repositioning post- deployment
US11147668B2 (en) 2018-02-07 2021-10-19 Boston Scientific Scimed, Inc. Medical device delivery system with alignment feature
US11439732B2 (en) 2018-02-26 2022-09-13 Boston Scientific Scimed, Inc. Embedded radiopaque marker in adaptive seal
US11051934B2 (en) 2018-02-28 2021-07-06 Edwards Lifesciences Corporation Prosthetic mitral valve with improved anchors and seal
WO2019195860A2 (en) 2018-04-04 2019-10-10 Vdyne, Llc Devices and methods for anchoring transcatheter heart valve
US11229517B2 (en) 2018-05-15 2022-01-25 Boston Scientific Scimed, Inc. Replacement heart valve commissure assembly
AU2018424859B2 (en) 2018-05-23 2024-04-04 Corcym S.R.L. A cardiac valve prosthesis
US11241310B2 (en) 2018-06-13 2022-02-08 Boston Scientific Scimed, Inc. Replacement heart valve delivery device
USD908874S1 (en) 2018-07-11 2021-01-26 Edwards Lifesciences Corporation Collapsible heart valve sizer
US11071627B2 (en) 2018-10-18 2021-07-27 Vdyne, Inc. Orthogonally delivered transcatheter heart valve frame for valve in valve prosthesis
US11278437B2 (en) 2018-12-08 2022-03-22 Vdyne, Inc. Compression capable annular frames for side delivery of transcatheter heart valve replacement
US11344413B2 (en) 2018-09-20 2022-05-31 Vdyne, Inc. Transcatheter deliverable prosthetic heart valves and methods of delivery
US10595994B1 (en) 2018-09-20 2020-03-24 Vdyne, Llc Side-delivered transcatheter heart valve replacement
US10321995B1 (en) 2018-09-20 2019-06-18 Vdyne, Llc Orthogonally delivered transcatheter heart valve replacement
US11109969B2 (en) 2018-10-22 2021-09-07 Vdyne, Inc. Guidewire delivery of transcatheter heart valve
CA3118599A1 (en) 2018-11-08 2020-05-14 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
WO2020123486A1 (en) 2018-12-10 2020-06-18 Boston Scientific Scimed, Inc. Medical device delivery system including a resistance member
US11253359B2 (en) 2018-12-20 2022-02-22 Vdyne, Inc. Proximal tab for side-delivered transcatheter heart valves and methods of delivery
US11273032B2 (en) 2019-01-26 2022-03-15 Vdyne, Inc. Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis
US11185409B2 (en) 2019-01-26 2021-11-30 Vdyne, Inc. Collapsible inner flow control component for side-delivered transcatheter heart valve prosthesis
EP3920849A1 (en) 2019-02-04 2021-12-15 Medtronic, Inc. Balloon expandable frame for transcatheter implantation of a cardiac valve prosthesis
WO2020181154A2 (en) 2019-03-05 2020-09-10 Vdyne, Inc. Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis
US11173027B2 (en) 2019-03-14 2021-11-16 Vdyne, Inc. Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same
US11076956B2 (en) 2019-03-14 2021-08-03 Vdyne, Inc. Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
AU2020271896B2 (en) 2019-04-10 2022-10-13 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
JP2022530764A (ja) 2019-05-04 2022-07-01 ブイダイン，インコーポレイテッド 生来の弁輪での側方送達される人工心臓弁を展開するための締め付けデバイス及び方法
US11439504B2 (en) 2019-05-10 2022-09-13 Boston Scientific Scimed, Inc. Replacement heart valve with improved cusp washout and reduced loading
US11771554B2 (en) 2019-05-17 2023-10-03 Medtronic, Inc. Supra annular tapered balloon expandable stent for transcatheter implantation of a cardiac valve prosthesis
EP3972673A4 (en) 2019-05-20 2023-06-07 Neovasc Tiara Inc. INTRODUCER DEVICE WITH HEMOSTASIS MECHANISM
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
CA3152042A1 (en) 2019-08-20 2021-02-25 Vdyne, Inc. Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves
JP2022545728A (ja) 2019-08-26 2022-10-28 ブイダイン，インコーポレイテッド 側方送達可能な経カテーテル人工弁ならびにそれらを送達及び固定するための方法
EP3831343B1 (en) 2019-12-05 2024-01-31 Tendyne Holdings, Inc. Braided anchor for mitral valve
US11648114B2 (en) 2019-12-20 2023-05-16 Tendyne Holdings, Inc. Distally loaded sheath and loading funnel
US11234813B2 (en) 2020-01-17 2022-02-01 Vdyne, Inc. Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery
US11951002B2 (en) 2020-03-30 2024-04-09 Tendyne Holdings, Inc. Apparatus and methods for valve and tether fixation
WO2022039853A1 (en) 2020-08-19 2022-02-24 Tendyne Holdings, Inc. Fully-transseptal apical pad with pulley for tensioning

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078268A (en) * 1975-04-24 1978-03-14 St. Jude Medical, Inc. Heart valve prosthesis
US4491986A (en) * 1976-05-12 1985-01-08 Shlomo Gabbay Heart valve
US4759758A (en) * 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
DE3782983T2 (de) 1986-07-30 1993-04-08 Hitachi Ltd Verfahren zur herstellung eines polyimidfilms durch chemische ablagerung aus der dampfphase.
DE3701704C1 (de) * 1987-01-22 1988-08-18 Braun Melsungen Ag Herzklappenprothese
US4994077A (en) * 1989-04-21 1991-02-19 Dobben Richard L Artificial heart valve for implantation in a blood vessel
DK124690D0 (da) * 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes til implantering i kroppen for erstatning af naturlig klap samt kateter til brug ved implantering af en saadan klapprotese
US5411552A (en) * 1990-05-18 1995-05-02 Andersen; Henning R. Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis
US5108425A (en) * 1990-05-30 1992-04-28 Hwang Ned H C Low turbulence heart valve
AU662342B2 (en) * 1991-05-16 1995-08-31 3F Therapeutics, Inc. Cardiac valve
US5370685A (en) † 1991-07-16 1994-12-06 Stanford Surgical Technologies, Inc. Endovascular aortic valve replacement
US5354330A (en) * 1991-10-31 1994-10-11 Ats Medical Inc. Heart valve prosthesis
US5332402A (en) * 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
US5178632A (en) * 1992-06-09 1993-01-12 Hanson Richard D Bi-leaflet heart valve prosthesis
US5772694A (en) * 1995-05-16 1998-06-30 Medical Carbon Research Institute L.L.C. Prosthetic heart valve with improved blood flow
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
GB9701479D0 (en) * 1997-01-24 1997-03-12 Aortech Europ Ltd Heart valve
US5957949A (en) * 1997-05-01 1999-09-28 World Medical Manufacturing Corp. Percutaneous placement valve stent
US5908451A (en) * 1997-11-25 1999-06-01 Cardiotech International Corporation Prosthetic heart valve
US5964405A (en) * 1998-02-20 1999-10-12 Sulzer Metco (Us) Inc. Arc thermal spray gun and gas cap therefor
US6091042A (en) * 1998-03-11 2000-07-18 Sulzer Metco (Us) Inc. Arc thermal spray gun extension and gas jet member therefor
EP1143882B1 (en) * 1999-01-26 2007-12-05 Edwards Lifesciences Corporation Flexible heart valve
US6425916B1 (en) * 1999-02-10 2002-07-30 Michi E. Garrison Methods and devices for implanting cardiac valves
US6076742A (en) * 1999-03-11 2000-06-20 Sulzer Metco (Us) Inc. Arc thermal spray gun extension with conical spray
US7147663B1 (en) * 1999-04-23 2006-12-12 St. Jude Medical Atg, Inc. Artificial heart valve attachment apparatus and methods
US6790229B1 (en) * 1999-05-25 2004-09-14 Eric Berreklouw Fixing device, in particular for fixing to vascular wall tissue
US6287339B1 (en) * 1999-05-27 2001-09-11 Sulzer Carbomedics Inc. Sutureless heart valve prosthesis
US6241763B1 (en) * 1999-06-08 2001-06-05 William J. Drasler In situ venous valve device and method of formation
US6312465B1 (en) * 1999-07-23 2001-11-06 Sulzer Carbomedics Inc. Heart valve prosthesis with a resiliently deformable retaining member
US6761736B1 (en) * 1999-11-10 2004-07-13 St. Jude Medical, Inc. Medical article with a diamond-like carbon coated polymer
US7018406B2 (en) * 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
US8579966B2 (en) * 1999-11-17 2013-11-12 Medtronic Corevalve Llc Prosthetic valve for transluminal delivery
FR2800984B1 (fr) * 1999-11-17 2001-12-14 Jacques Seguin Dispositif de remplacement d'une valve cardiaque par voie percutanee
US6458153B1 (en) * 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US7195641B2 (en) * 1999-11-19 2007-03-27 Advanced Bio Prosthetic Surfaces, Ltd. Valvular prostheses having metal or pseudometallic construction and methods of manufacture
NZ520462A (en) * 2000-01-27 2004-08-27 3F Therapeutics Inc Prosthetic heart valve
DE10010074B4 (de) * 2000-02-28 2005-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen
US6454799B1 (en) * 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US6572652B2 (en) * 2000-08-29 2003-06-03 Venpro Corporation Method and devices for decreasing elevated pulmonary venous pressure
US7510572B2 (en) * 2000-09-12 2009-03-31 Shlomo Gabbay Implantation system for delivery of a heart valve prosthesis
ES2247198T3 (es) * 2000-11-21 2006-03-01 Rex Medical, Lp Valvula aortica percutanea.
US20050182483A1 (en) * 2004-02-11 2005-08-18 Cook Incorporated Percutaneously placed prosthesis with thromboresistant valve portion
US6767109B2 (en) * 2001-06-06 2004-07-27 Ivoclar Vivadent Ag Light hardening device and a light source suitable for use in a light hardening device
FR2826863B1 (fr) * 2001-07-04 2003-09-26 Jacques Seguin Ensemble permettant la mise en place d'une valve prothetique dans un conduit corporel
US6893460B2 (en) * 2001-10-11 2005-05-17 Percutaneous Valve Technologies Inc. Implantable prosthetic valve
US20030130729A1 (en) * 2002-01-04 2003-07-10 David Paniagua Percutaneously implantable replacement heart valve device and method of making same
WO2003068108A1 (en) * 2002-02-14 2003-08-21 St. Jude Medical, Inc. Heart valve structures
WO2003094795A1 (en) * 2002-05-10 2003-11-20 Cordis Corporation Method of making a medical device having a thin wall tubular membrane over a structural frame
US7351256B2 (en) * 2002-05-10 2008-04-01 Cordis Corporation Frame based unidirectional flow prosthetic implant
DE20321838U1 (de) 2002-08-13 2011-02-10 JenaValve Technology Inc., Wilmington Vorrichtung zur Verankerung und Ausrichtung von Herzklappenprothesen
KR100442330B1 (ko) * 2002-09-03 2004-07-30 주식회사 엠아이텍 스텐트 및 이 스텐트의 제조방법
US6875231B2 (en) * 2002-09-11 2005-04-05 3F Therapeutics, Inc. Percutaneously deliverable heart valve
JP2006500188A (ja) * 2002-09-20 2006-01-05 インプライアント・リミテッド 人工器官用の機械的に取り付けられたエラストマーのカバー
US7137184B2 (en) * 2002-09-20 2006-11-21 Edwards Lifesciences Corporation Continuous heart valve support frame and method of manufacture
US7399315B2 (en) * 2003-03-18 2008-07-15 Edwards Lifescience Corporation Minimally-invasive heart valve with cusp positioners
EP1615595B1 (en) * 2003-04-24 2009-10-21 Cook Incorporated Artificial valve prosthesis with improved flow dynamics
RU2006103367A (ru) 2003-07-08 2006-06-27 Вентор Текнолоджиз Лтд. (Il) Имплантируемые протезные устройства, в частности, для трансартериальной доставки при лечении аортального стеноза и способы имплантации таких устройств
US7201772B2 (en) * 2003-07-08 2007-04-10 Ventor Technologies, Ltd. Fluid flow prosthetic device
US20050075713A1 (en) * 2003-10-06 2005-04-07 Brian Biancucci Minimally invasive valve replacement system
US10219899B2 (en) * 2004-04-23 2019-03-05 Medtronic 3F Therapeutics, Inc. Cardiac valve replacement systems
US7070616B2 (en) * 2003-10-31 2006-07-04 Cordis Corporation Implantable valvular prosthesis
US7261732B2 (en) * 2003-12-22 2007-08-28 Henri Justino Stent mounted valve
US8828078B2 (en) * 2003-12-23 2014-09-09 Sadra Medical, Inc. Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements
US20050137691A1 (en) * 2003-12-23 2005-06-23 Sadra Medical Two piece heart valve and anchor
US7381219B2 (en) * 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US8840663B2 (en) * 2003-12-23 2014-09-23 Sadra Medical, Inc. Repositionable heart valve method
ITTO20040135A1 (it) * 2004-03-03 2004-06-03 Sorin Biomedica Cardio Spa Protesi valvolare cardiaca
CN101052359A (zh) * 2004-04-23 2007-10-10 3F医疗有限公司 可植入的人工瓣膜
US8377118B2 (en) * 2004-05-05 2013-02-19 Direct Flow Medical, Inc. Unstented heart valve with formed in place support structure

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101287424B (zh) * 2004-12-30 2011-02-09 文托技术有限公司 流体流动修复装置
US11844345B2 (en) 2005-06-28 2023-12-19 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US11917991B2 (en) 2007-03-20 2024-03-05 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US11856944B2 (en) 2011-04-14 2024-01-02 Transmedics, Inc. Organ care solution for ex-vivo machine perfusion of donor lungs
US11944088B2 (en) 2014-06-02 2024-04-02 Transmedics, Inc. Ex vivo organ care system
US11903381B2 (en) 2014-06-02 2024-02-20 Transmedics, Inc. Ex vivo organ care system
CN111134899A (zh) * 2015-02-12 2020-05-12 赫莫迪纳克斯科技有限公司 主动脉植入物
CN111134899B (zh) * 2015-02-12 2022-06-10 赫莫迪纳克斯科技有限公司 主动脉植入物
CN112933394B (zh) * 2015-09-09 2023-10-24 特兰斯迈迪茨公司 用于在离体器官护理系统中使用的主动脉插管
CN112933394A (zh) * 2015-09-09 2021-06-11 特兰斯迈迪茨公司 用于在离体器官护理系统中使用的主动脉插管
CN106377341B (zh) * 2016-09-29 2018-02-16 复旦大学附属中山医院 一种血流分流器
CN106377341A (zh) * 2016-09-29 2017-02-08 复旦大学附属中山医院 一种血流分流器
CN113164720A (zh) * 2018-09-19 2021-07-23 Nxt生物医疗有限责任公司 在生物结构的脉管和腔室之间建立连接和分流的方法和技术

Also Published As

Publication number Publication date
WO2005002466A3 (en) 2005-03-03
WO2005002466A2 (en) 2005-01-13
EP1648339B1 (en) 2013-02-20
CN1849102B (zh) 2011-01-19
US20060259134A1 (en) 2006-11-16
KR20060112705A (ko) 2006-11-01
EP1648339A4 (en) 2011-03-16
BRPI0412362A (pt) 2006-09-05
EP1648339A2 (en) 2006-04-26
EP1648339B2 (en) 2020-06-17
CA2531528A1 (en) 2005-01-13
AU2004253375B2 (en) 2011-07-14
AU2004253375A2 (en) 2005-01-13
AU2004253375A1 (en) 2005-01-13
CA2531528C (en) 2013-09-03
NO20060588L (no) 2006-04-10
JP4942031B2 (ja) 2012-05-30
JP2007526789A (ja) 2007-09-20
US7429269B2 (en) 2008-09-30
RU2006103367A (ru) 2006-06-27

Similar Documents

Publication Publication Date Title
CN1849102A (zh) 用于主动脉瓣狭窄治疗中通过动脉输送的可植入式修复装置及其方法
JP4824699B2 (ja) 人工液流補綴装置
JP6876664B2 (ja) 置換心臓弁を植え込むための装置および方法
US8597347B2 (en) Heart regurgitation method and apparatus
CN111134899B (zh) 主动脉植入物
US8840661B2 (en) Atraumatic prosthetic heart valve prosthesis
US8246675B2 (en) Kit for implanting in a duct
CN108495602A (zh) 用于再定位完全部署的瓣膜组件的系统
CN106510902A (zh) 用于二尖瓣反流治疗装置的方法和设计
US20040210306A1 (en) Device for reduction of pressure effects of cardiac tricuspid valve regurgitation
CN106604699A (zh) 二尖瓣修复和替换设备及方法
CN108430395A (zh) 具有流动引导器的假体瓣膜
WO2019149173A1 (zh) 扩张球囊以及球囊扩张导管
CN209301400U (zh) 一种人工二尖瓣介入置换装置
CN2855365Y (zh) 人工心脏支架瓣膜的输放装置
CN107468379B (zh) 一种主动脉瓣膜支架输送系统及主动脉瓣膜系统

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110119