DE10012007T1 - Automatisches Diagnoseanalysegerät und Verfahren - Google Patents

Automatisches Diagnoseanalysegerät und Verfahren Download PDF

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Publication number
DE10012007T1
DE10012007T1 DE10012007T DE10012007T DE10012007T1 DE 10012007 T1 DE10012007 T1 DE 10012007T1 DE 10012007 T DE10012007 T DE 10012007T DE 10012007 T DE10012007 T DE 10012007T DE 10012007 T1 DE10012007 T1 DE 10012007T1
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Prior art keywords
station
reaction vessel
constructed
automated
automated apparatus
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DE10012007T
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DE10012007A1 (de
Inventor
wird später genannt werden Erfinder
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Gen Probe Inc
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Gen Probe Inc
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Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Publication of DE10012007T1 publication Critical patent/DE10012007T1/de
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    • Y10T436/2575—Volumetric liquid transfer

Abstract

Automatisiertes Gerät zum Isolieren und Amplifizieren einer Target-Nukleinsäuresequenz, die in einer Flüssigkeitsprobe vorliegen kann, wobei das Gerät umfasst: eine Trennungsstation, die konstruiert und angeordnet ist, um die Target-Sequenz von anderem Material, das in der Flüssigkeitsprobe vorhanden ist, abzutrennen, eine Amplifikationsstation, die einen Inkubator oder mehrere Inkubatoren umfasst, wobei jeder der Inkubatoren eine Temperatur-regulierte Kammer definiert, die konstruiert und angeordnet ist, um einen Reaktionsbehälter, der die abgetrennte Target-Sequenz enthält, aufzunehmen und die Inhalte des Reaktionsbehälters, dem ein oder mehrere Amplifikationsreagenzien zugesetzt wurden, für einen Zeitraum und unter Bedingungen, die ausreichend sind, damit die Target-Sequenz amplifiziert werden kann, zu inkubieren, und einen oder mehrere Transportmechanismen, die aufgebaut und angeordnet sind, um den Reaktionsbehälter zwischen Stationen des Geräts zu transportieren.

Claims (17)

  1. Automatisiertes Gerät zum Isolieren und Amplifizieren einer Target-Nukleinsäuresequenz, die in einer Flüssigkeitsprobe vorliegen kann, wobei das Gerät umfasst: eine Trennungsstation, die konstruiert und angeordnet ist, um die Target-Sequenz von anderem Material, das in der Flüssigkeitsprobe vorhanden ist, abzutrennen, eine Amplifikationsstation, die einen Inkubator oder mehrere Inkubatoren umfasst, wobei jeder der Inkubatoren eine Temperatur-regulierte Kammer definiert, die konstruiert und angeordnet ist, um einen Reaktionsbehälter, der die abgetrennte Target-Sequenz enthält, aufzunehmen und die Inhalte des Reaktionsbehälters, dem ein oder mehrere Amplifikationsreagenzien zugesetzt wurden, für einen Zeitraum und unter Bedingungen, die ausreichend sind, damit die Target-Sequenz amplifiziert werden kann, zu inkubieren, und einen oder mehrere Transportmechanismen, die aufgebaut und angeordnet sind, um den Reaktionsbehälter zwischen Stationen des Geräts zu transportieren.
  2. Automatisiertes Gerät nach Anspruch 1, das außerdem eine Immobilisierungsstation umfasst, die einen Inkubator oder mehrere Inkubatoren umfasst, wobei jeder der Inkubatoren der Immobilisierungsstation eine Temperatur-regulierte Kammer definiert, die konstruiert und angeordnet ist, um den Reaktionsbehälter aufzunehmen und die Inhalte des Reaktionsbehälters, für die ein festes Trägermaterial bereitgestellt wurde, für einen Zeitraum und unter Bedingungen, die ausreichend sind, damit die Target-Sequenz durch das feste Trägermaterial immobilisiert werden kann, zu inkubieren, wobei die Trennungsstation konstruiert und angeordnet ist, um die Target-Sequenz von der Nicht-Target-Nukleinsäure durch ein Verfahren zu trennen, welches Isolieren des festen Trägermaterials in dem Reaktionsbehälter und Entfernen der Flüssigkeitsprobe davon umfasst.
  3. Automatisiertes Gerät nach Anspruch 2, wobei die Immobilisierungs- und Amplifikationsstationen voneinander unabhängig sind oder wenigstens einen Inkubator miteinander teilen.
  4. Automatisiertes Gerät nach einem der Ansprüche 1 bis 3, das außerdem eine Haltestation zum Halten einer Vielzahl von Reaktionsbehältern umfasst.
  5. Automatisiertes Gerät nach einem der Ansprüche 1 bis 4, wobei die Trennungsstation magnetische Elemente zum Aussetzen der Flüssigkeitsprobe einem Magnetfeld umfasst.
  6. Automatisiertes Gerät nach einem der Ansprüche 1 bis 5, wobei die Trennungsstation außerdem umfasst: einen Flüssigkeitsabgabemechanismus, der konstruiert und angeordnet ist, um einen Waschpuffer für den Reaktionsbehälter nach Entfernen der Flüssigkeitsprobe aus dem Reaktionsbehälter bereitzustellen, und eine Mischvorrichtung, die konstruiert und angeordnet ist, um den Reaktionsbehälter zu bewegen, um das feste Trägermaterial zu resuspendieren, nachdem der Waschpuffer durch den Flüssigkeitsabgabemechanismus bereitgestellt wurde.
  7. Automatisiertes Gerät nach einem der Ansprüche 1 bis 6, wobei die Flüssigkeitsprobe in dem Reaktionsbehälter in der Trennungsstation enthalten ist und wobei die Trennungsstation einen Flüssigkeitsabsaugmechanismus umfasst, der konstruiert und angeordnet ist, um Flüssigkeitsprobe aus dem Reaktionsbehälter nach Isolieren des festen Trägermaterials abzusaugen.
  8. Automatisiertes Gerät nach einem der Ansprüche 2 bis 4, wobei die Inkubatoren der Amplifikationsstation bei einer Temperatur oder bei Temperaturen gehalten werden, die sich von der Temperatur oder den Temperaturen, die durch die Inkubatoren der Immobilisierungsstation aufrecht gehalten wird/werden, unterscheidet/unterscheiden.
  9. Automatisiertes Gerät nach einem der Ansprüche 1 bis 8, das außerdem eine Hybridisierungsstation umfasst, die einen Inkubator oder mehrere Inkubatoren umfasst, wobei jeder der Inkubatoren der Hybridisierungsstation eine Temperaturregulierte Kammer definiert, die konstruiert und angeordnet ist, um den Reaktionsbehälter aufzunehmen und die Inhalte des Reaktionsbehälters, denen eine oder mehrere Sondenreagenzien zugesetzt wurden, für einen Zeitraum und unter Bedingungen, die ausreichend sind, damit die Sonde an die Target-Sequenz oder ein Amplikon davon hybridisieren kann, zu inkubieren.
  10. Automatisiertes Gerät nach Anspruch 9, wobei die Amplifikations- und Hybridisierungsstationen voneinander unabhängig sind oder wenigstens einen Inkubator miteinander teilen.
  11. Automatisiertes Gerät nach einem der Ansprüche 1 bis 10, das außerdem eine Detektionsstation umfasst, die konstruiert und angeordnet ist, um das Vorliegen oder die Abwesenheit der Sonde, die an die Target-Sequenz oder ein Amplikon davon hybridisiert ist, als Hinweis für das Vorliegen oder die Abwesenheit eines Organismus oder Virus oder eines oder mehrerer Mitglieder einer Gruppe von Organismen oder Viren in der Flüssigkeitsprobe zu detektieren.
  12. Automatisiertes Gerät nach Anspruch 11, wobei die Detektionsstation ein Luminometer umfasst, das konstruiert und angeordnet ist, um die Menge an Licht, die durch die Inhalte des Reaktionsbehälters emittiert wird, zu detektieren.
  13. Automatisiertes Gerät nach einem der Ansprüche 1 bis 11, außerdem umfassend eine Temperaturänderungsstation, die konstruiert und angeordnet ist, um die Temperatur der Inhalte des Reaktionsbehälters vor Transportieren des Reaktionsbehälters zu der Amplifikationsstation zu erhöhen oder zu senken, und/oder außerdem umfassend eine Flüssigkeitsabgabestation, die konstruiert und angeordnet ist, um die Flüssigkeitsprobe in den Reaktionsbehälter abzugeben, und/oder außerdem umfassend eine Deaktivierungsstation, die konstruiert und angeordnet ist, um die Nukleinsäureinhalte des Reaktionsbehälters zu deaktivieren, nachdem zugelassen wurde, dass die Target-Sequenz, wenn überhaupt, amplifiziert wird.
  14. Automatisiertes Gerät nach einem der Ansprüche 1 bis 13, wobei der Reaktionsbehälter eine Vielzahl von einzelnen Behältergefäßen umfasst.
  15. Automatisiertes Gerät nach Anspruch 14, wobei die Behältergefäße zylindrische Röhrchen sind, die so geformt sind, dass sie offene obere Enden und geschlossene Bodenenden haben.
  16. Automatisiertes Gerät nach einem der Ansprüche 1 bis 15, wobei die Stationen des Geräts an einer einzelnen eigenständigen Plattform angeordnet sind.
  17. Automatisiertes Gerät nach einem der Ansprüche 1 bis 16, wobei die Stationen vorzugsweise in einem Gehäuse enthalten sind, wobei das Gehäuse eine eigenständige, selbständige Analysatoreinheit definiert.
DE10012007T 1998-05-01 1999-04-30 Automatisches Diagnoseanalysegerät und Verfahren Pending DE10012007T1 (de)

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DE69940490T Expired - Lifetime DE69940490D1 (de) 1998-05-01 1999-04-30 Automatisches Isolierungs- und Amplifizierungsverfahren für eine Zielnukleinsäuresequenz
DE69936897T Expired - Lifetime DE69936897T2 (de) 1998-05-01 1999-04-30 Inkubator für automatische Analysevorrichtung
DE69942654T Expired - Lifetime DE69942654D1 (de) 1998-05-01 1999-04-30 Transportvorrichtung für automatische Analysevorrichtung
DE09004018T Pending DE09004018T1 (de) 1998-05-01 1999-04-30 Automatisches Diagnoseanalysegerät und Verfahren
DE10011547T Pending DE10011547T1 (de) 1998-05-01 1999-04-30 System und Verfahren zur Inkubation des Inhalts eines Reaktionsbehälters
DE10011529T Pending DE10011529T1 (de) 1998-05-01 1999-04-30 Automatisches Diagnoseanalysegerät und Verfahren
DE69928390T Expired - Lifetime DE69928390T2 (de) 1998-05-01 1999-04-30 Automatisiertes diagnostisches analyseverfahren
DE69939347T Expired - Lifetime DE69939347D1 (de) 1998-05-01 1999-04-30 Luminometer für eine automatische Analysevorrichtung
DE69940647T Expired - Lifetime DE69940647D1 (de) 1998-05-01 1999-04-30 Automatische diagnostische Analysevorrichtung
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DE69936897T Expired - Lifetime DE69936897T2 (de) 1998-05-01 1999-04-30 Inkubator für automatische Analysevorrichtung
DE69942654T Expired - Lifetime DE69942654D1 (de) 1998-05-01 1999-04-30 Transportvorrichtung für automatische Analysevorrichtung
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