DE1015608T1 - Methoden zur bestimmung der rezeptoraktivität und dafür verwendbare konstrukte - Google Patents

Methoden zur bestimmung der rezeptoraktivität und dafür verwendbare konstrukte

Info

Publication number
DE1015608T1
DE1015608T1 DE1015608T DE98925260T DE1015608T1 DE 1015608 T1 DE1015608 T1 DE 1015608T1 DE 1015608 T DE1015608 T DE 1015608T DE 98925260 T DE98925260 T DE 98925260T DE 1015608 T1 DE1015608 T1 DE 1015608T1
Authority
DE
Germany
Prior art keywords
methods
receptor activity
used therefor
gpcr
constructs used
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE1015608T
Other languages
English (en)
Inventor
S Barak
G Caron
S Ferguson
Jie Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Durham
Duke University
Original Assignee
University of Durham
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Durham, Duke University filed Critical University of Durham
Publication of DE1015608T1 publication Critical patent/DE1015608T1/de
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
DE1015608T 1997-06-05 1998-06-04 Methoden zur bestimmung der rezeptoraktivität und dafür verwendbare konstrukte Pending DE1015608T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/869,568 US5891646A (en) 1997-06-05 1997-06-05 Methods of assaying receptor activity and constructs useful in such methods
PCT/US1998/011628 WO1998055635A1 (en) 1997-06-05 1998-06-04 Methods of assaying receptor activity and constructs useful in such methods

Publications (1)

Publication Number Publication Date
DE1015608T1 true DE1015608T1 (de) 2002-11-14

Family

ID=25353824

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69841908T Expired - Lifetime DE69841908D1 (de) 1997-06-05 1998-06-04 Verfahren zur Bestimmung der Rezeptoraktivität und dafür verwendbare Konstrukte
DE1998622484 Expired - Lifetime DE69822484T2 (de) 1997-06-05 1998-06-04 Methoden zur bestimmung der rezeptoraktivität und dafür verwendbare konstrukte
DE1015608T Pending DE1015608T1 (de) 1997-06-05 1998-06-04 Methoden zur bestimmung der rezeptoraktivität und dafür verwendbare konstrukte

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69841908T Expired - Lifetime DE69841908D1 (de) 1997-06-05 1998-06-04 Verfahren zur Bestimmung der Rezeptoraktivität und dafür verwendbare Konstrukte
DE1998622484 Expired - Lifetime DE69822484T2 (de) 1997-06-05 1998-06-04 Methoden zur bestimmung der rezeptoraktivität und dafür verwendbare konstrukte

Country Status (10)

Country Link
US (5) US5891646A (de)
EP (2) EP1441032B1 (de)
AT (2) ATE482276T1 (de)
AU (1) AU759347B2 (de)
CA (1) CA2305810C (de)
DE (3) DE69841908D1 (de)
DK (1) DK1015608T3 (de)
ES (1) ES2182736T3 (de)
PT (1) PT1015608E (de)
WO (1) WO1998055635A1 (de)

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US5891646A (en) 1999-04-06
DE69841908D1 (de) 2010-11-04
WO1998055635A9 (en) 2003-05-08
ES2182736T3 (es) 2004-09-01
EP1441032B1 (de) 2010-09-22
DE69822484T2 (de) 2005-01-13
EP1441032A1 (de) 2004-07-28
ATE262040T1 (de) 2004-04-15
US20040101887A1 (en) 2004-05-27
WO1998055635A1 (en) 1998-12-10
US20060188944A1 (en) 2006-08-24
AU759347B2 (en) 2003-04-10
ES2182736T1 (es) 2003-03-16
EP1015608B1 (de) 2004-03-17
CA2305810A1 (en) 1998-12-10
PT1015608E (pt) 2004-07-30
EP1015608A1 (de) 2000-07-05
US6110693A (en) 2000-08-29
DK1015608T3 (da) 2004-06-01
US20080261256A1 (en) 2008-10-23
CA2305810C (en) 2007-11-20
ATE482276T1 (de) 2010-10-15
US7138240B2 (en) 2006-11-21
AU7725598A (en) 1998-12-21

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