DE122011100044I1 - Neue 1,2,4-Triaminobenzol-Derivate und Verfahren zu deren Herstellung. - Google Patents
Neue 1,2,4-Triaminobenzol-Derivate und Verfahren zu deren Herstellung.Info
- Publication number
- DE122011100044I1 DE122011100044I1 DE201112100044 DE122011100044C DE122011100044I1 DE 122011100044 I1 DE122011100044 I1 DE 122011100044I1 DE 201112100044 DE201112100044 DE 201112100044 DE 122011100044 C DE122011100044 C DE 122011100044C DE 122011100044 I1 DE122011100044 I1 DE 122011100044I1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- radical
- nhco
- alkoxy
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- JSYBAZQQYCNZJE-UHFFFAOYSA-N benzene-1,2,4-triamine Chemical class NC1=CC=C(N)C(N)=C1 JSYBAZQQYCNZJE-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 14
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- -1 C3-C7-cycloalkyl Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4200259A DE4200259A1 (de) | 1992-01-08 | 1992-01-08 | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
DE122011100044I1 true DE122011100044I1 (de) | 2012-01-19 |
Family
ID=6449201
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4200259A Withdrawn DE4200259A1 (de) | 1992-01-08 | 1992-01-08 | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
DE59205496T Expired - Lifetime DE59205496D1 (de) | 1992-01-08 | 1992-12-10 | Neue 1,2,4-Triaminobenzol-Derivate und Verfahren zu deren Herstellung |
DE201112100044 Pending DE122011100044I1 (de) | 1992-01-08 | 2011-09-07 | Neue 1,2,4-Triaminobenzol-Derivate und Verfahren zu deren Herstellung. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4200259A Withdrawn DE4200259A1 (de) | 1992-01-08 | 1992-01-08 | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
DE59205496T Expired - Lifetime DE59205496D1 (de) | 1992-01-08 | 1992-12-10 | Neue 1,2,4-Triaminobenzol-Derivate und Verfahren zu deren Herstellung |
Country Status (13)
Country | Link |
---|---|
US (1) | US5384330A (de) |
EP (1) | EP0554543B1 (de) |
JP (1) | JP3145220B2 (de) |
AT (1) | ATE134611T1 (de) |
CA (1) | CA2086654C (de) |
DE (3) | DE4200259A1 (de) |
DK (1) | DK0554543T3 (de) |
ES (1) | ES2084914T3 (de) |
GR (1) | GR3019653T3 (de) |
LU (1) | LU91869I2 (de) |
MX (1) | MX9300014A (de) |
SG (1) | SG48046A1 (de) |
ZA (1) | ZA9311B (de) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0809492A4 (de) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | Il-8 rezeptor antagonisten |
US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
DE19539861A1 (de) * | 1995-10-26 | 1997-04-30 | Asta Medica Ag | Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen |
US6005008A (en) * | 1996-02-16 | 1999-12-21 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US6211373B1 (en) | 1996-03-20 | 2001-04-03 | Smithkline Beecham Corporation | Phenyl urea antagonists of the IL-8 receptor |
US6262113B1 (en) | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US6271261B1 (en) | 1996-06-27 | 2001-08-07 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
BR9709952A (pt) * | 1996-06-27 | 1999-08-10 | Smithkline Beecham Corp | Antagonistas de receptor de il-8 |
DE19701694A1 (de) * | 1997-01-20 | 1998-07-23 | Asta Medica Ag | Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung |
DE19752748A1 (de) | 1997-11-28 | 1999-06-02 | Bayer Ag | Substituierte Phenyluracile |
GB9915414D0 (en) * | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Medical use |
US6117900A (en) * | 1999-09-27 | 2000-09-12 | Asta Medica Aktiengesellschaft | Use of retigabine for the treatment of neuropathic pain |
US6378671B1 (en) | 2000-03-29 | 2002-04-30 | Lord Corporation | Magnetically actuated motion control device |
TWI287984B (en) | 2000-10-17 | 2007-10-11 | Wyeth Corp | Pharmaceutical composition for modulating bladder function |
US6589986B2 (en) * | 2000-12-20 | 2003-07-08 | Wyeth | Methods of treating anxiety disorders |
US20020183395A1 (en) * | 2001-04-04 | 2002-12-05 | Wyeth | Methods for treating hyperactive gastric motility |
DE10136046A1 (de) * | 2001-07-25 | 2003-02-13 | Viatris Gmbh | Verfahren zur Herstellung von 1,2,4-Triaminobenzol-carbamidsäureestern |
US7205307B2 (en) | 2002-02-14 | 2007-04-17 | Icagen, Inc. | Pyrimidines as novel openers of potassium ion channels |
US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
PT1578740E (pt) * | 2002-12-27 | 2007-05-31 | Lundbeck & Co As H | Derivados de 1, 2, 4-triaminobenzeno úteis para tratamento de distúrbios do sistema nervoso central |
TWI325414B (en) * | 2002-12-27 | 2010-06-01 | Lundbeck & Co As H | 1,2,4-triaminobenzene derivatives |
WO2004082677A1 (en) | 2003-03-21 | 2004-09-30 | H. Lundbeck A/S | Substituted p-diaminobenzene derivatives |
AU2004233941A1 (en) * | 2003-04-25 | 2004-11-11 | H. Lundbeck A/S | Sustituted indoline and indole derivatives |
US7799832B2 (en) * | 2003-10-23 | 2010-09-21 | Valeant Pharmaceuticals North America | Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
TWI349666B (en) | 2004-03-12 | 2011-10-01 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivatives |
UA89503C2 (uk) | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
CA2599890C (en) | 2005-03-03 | 2011-05-03 | H. Lundbeck A/S | Substituted pyridine derivatives |
AR055054A1 (es) * | 2005-04-22 | 2007-08-01 | Wyeth Corp | Cristales formados de clorhidrato de (((2r)-7-(2,6-diclorofenil)-5-fluoro-2,3- dihidro-1-benzofurano-2-il) metil ) amina |
JP2008538573A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | ベンゾフラニルアルカナミン誘導体およびその5−ht2cアゴニストとしての使用 |
AU2006239920A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
WO2006116170A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | Dihydrobenzofuran derivatives and uses thereof |
GT200600162A (es) * | 2005-04-24 | 2007-03-14 | Metodos para modular la funcion de la vejiga | |
AR054849A1 (es) * | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
US20090118285A1 (en) | 2006-02-07 | 2009-05-07 | H. Lundbeck A/S | Use of kcnq-openers for treating or reducing the symptoms of schizophrenia |
MX2008012092A (es) * | 2006-03-24 | 2008-10-03 | Wyeth Corp | Tratamiento del dolor. |
CN101410112A (zh) * | 2006-03-24 | 2009-04-15 | 惠氏公司 | 治疗抑郁症的新治疗组合 |
US7960436B2 (en) * | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
US20080045534A1 (en) * | 2006-08-18 | 2008-02-21 | Valeant Pharmaceuticals North America | Derivatives of 1,3-diamino benzene as potassium channel modulators |
KR20090079191A (ko) * | 2006-08-23 | 2009-07-21 | 밸리언트 파마슈티컬즈 인터내셔널 | 칼륨 채널 조절제로서 4-(n-아자사이클로알킬) 아닐리드의 유도체 |
US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
ATE538084T1 (de) * | 2006-11-28 | 2012-01-15 | Valeant Pharmaceuticals Int | Bicyclische 1,4-retigabin-analoga als kaliumkanalhemmer |
US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
US8765815B2 (en) | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
CL2008002777A1 (es) * | 2007-09-21 | 2010-01-22 | Wyeth Corp | Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario. |
GB0723794D0 (en) | 2007-12-05 | 2008-01-16 | Lectus Therapeutics Ltd | Potassium ion channel modulators and uses thereof |
US20100323015A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
US20100323016A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
CA2731008A1 (en) * | 2008-07-18 | 2010-01-21 | Valeant Pharmaceuticals International | Modified release formulation and methods of use |
DE102009013611A1 (de) | 2009-03-17 | 2010-09-23 | Ratiopharm Gmbh | Festes Retigabin in nicht-kristalliner Form |
DE102009013613A1 (de) | 2009-03-17 | 2010-09-23 | Ratiopharm Gmbh | Trockenverarbeitung von Retigabin |
DE102009013612A1 (de) | 2009-03-17 | 2010-09-23 | Ratiopharm Gmbh | Retigabin-Tabletten, bevorzugt mit modifizierter Freisetzung |
WO2011012659A2 (en) | 2009-07-28 | 2011-02-03 | Medichem S.A. | Diethyl 4-(4-fluorobenzylamino)-1,2-phenylenedicarbamate, and salts thereof |
WO2011039369A2 (en) | 2009-10-02 | 2011-04-07 | Medichem S.A. | Amorphous forms of a 2-amino-4-(4-fluorobenzylamino)phenylcarbamate derivative |
SG181827A1 (en) | 2010-01-20 | 2012-07-30 | Glaxo Group Ltd | Novel retigabine composition |
EP2536394A2 (de) | 2010-02-19 | 2012-12-26 | Medichem S.A. | Stabilisierte phenylcarbamatderivate im festkörperzustand |
CN101921195A (zh) * | 2010-08-02 | 2010-12-22 | 北京德众万全医药科技有限公司 | 一种瑞替加滨中间体的简单合成方法 |
JP2014510714A (ja) * | 2011-01-18 | 2014-05-01 | グラクソ グループ リミテッド | レチガビンの製造方法 |
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WO2013011518A1 (en) | 2011-07-21 | 2013-01-24 | Arch Pharmalabs Limited | Process for the preparation of retigabine of the formula i and pharmaceutically acceptable salts thereof |
CN103073455B (zh) * | 2011-10-25 | 2015-08-19 | 中国科学院上海药物研究所 | 一类新型的kcnq钾通道激动剂、其制备方法和用途 |
CN102531966B (zh) * | 2011-12-23 | 2013-07-24 | 山东创新药物研发有限公司 | 瑞替加滨的晶型d及其制备方法 |
ITMI20120137A1 (it) * | 2012-02-02 | 2013-08-03 | Olon Spa | Procedimento ed intermedi per la preparazione di retigabina |
CN103373941B (zh) * | 2012-04-11 | 2016-08-17 | 浙江九洲药物科技有限公司 | 瑞替加滨及其中间体的制备方法 |
EP2844639A4 (de) * | 2012-04-30 | 2015-12-23 | Scifluor Life Sciences Llc | Fluorierte 2-amino-4-(benzylamino)phenylcarbamatderivate |
WO2014023270A1 (en) | 2012-08-09 | 2014-02-13 | Zentiva, K.S. | Salts or co-crystals of ethyl n-[2-amino-4-[(4-fluorophenyl)methylamino]-phenyl]carbamate |
ITMI20121922A1 (it) * | 2012-11-12 | 2014-05-13 | Dipharma Francis Srl | Procedimento per la preparazione di un composto anticonvulsivante |
CN103193657B (zh) * | 2013-04-16 | 2015-08-05 | 石家庄度恩医药科技有限公司 | 一种合成依佐加滨中间体的方法 |
CN103664678B (zh) * | 2013-11-06 | 2015-10-28 | 河北科技大学 | 一种n1-(4-氟苄基)-4-硝基苯基-1,3-二胺的中间体及其制备方法 |
CN105017085B (zh) | 2014-04-28 | 2018-06-29 | 中国科学院上海药物研究所 | 一类kcnq钾通道激动剂、其制备方法和用途 |
WO2016077724A1 (en) * | 2014-11-13 | 2016-05-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | (2-amino-4(arylamino)phenyl) carbamates |
JP2019518754A (ja) * | 2016-06-10 | 2019-07-04 | サイフルーア ライフ サイエンシズ インコーポレイテッド | フッ素化2−アミノ−4−(置換アミノ)フェニルカルバメート誘導体 |
JP6931701B2 (ja) | 2016-12-16 | 2021-09-08 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | T型カルシウムチャンネルブロッカーを含有する薬学的合剤 |
WO2019014547A1 (en) | 2017-07-14 | 2019-01-17 | Texas Tech University System | FUNCTIONALIZED PYRIDINE CARBAMATES HAVING ENHANCED NEUROPROTECTOR ACTIVITY |
EP3724163A4 (de) | 2017-12-13 | 2021-07-28 | SciFluor Life Sciences, Inc. | Fluorierte 4-(substituierte amino)phenyl-carbamat-derivate |
WO2019203951A1 (en) | 2018-04-20 | 2019-10-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Selective potassium channel agonists |
EP3917907A1 (de) | 2019-01-29 | 2021-12-08 | Universitá Degli Studi Di Salerno | Modulatoren von kaliumionenkanälen und verwendungen davon |
PE20221396A1 (es) | 2019-12-02 | 2022-09-14 | Xenon Pharmaceuticals Inc | Formulacion pediatrica de liberacion inmediata del abridor de canales de potasio ezogabina |
KR20230159531A (ko) * | 2021-03-19 | 2023-11-21 | 자이자겐, 인크. | Kv7 통로 개방제의 전구약물 |
WO2023091461A1 (en) | 2021-11-19 | 2023-05-25 | Icagen, Llc | Pyridine compounds as kv7.2 enhancers |
WO2023091554A1 (en) | 2021-11-19 | 2023-05-25 | Icagen, Llc | Novel heteroaryl-urea compounds as kv7.2 inhibitors |
WO2023121992A1 (en) | 2021-12-22 | 2023-06-29 | Icagen, Llc | Cyclopropyl compounds |
WO2023158584A1 (en) | 2022-02-15 | 2023-08-24 | Icagen, Llc | New bicyclopentane derivatives |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3337593A1 (de) * | 1982-10-27 | 1984-05-03 | Degussa Ag, 6000 Frankfurt | 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung |
MC2029A1 (fr) * | 1988-05-16 | 1990-04-25 | Asta Pharma Ag | (n-heterocyclyl)-3 diamino-2,6 pyridines substituees et leurs n-oxydes,preparation de ces composes et leur application comme medicaments |
DE3917113A1 (de) * | 1989-05-26 | 1990-11-29 | Schwarzkopf Gmbh Hans | Verfahren zur selektiven herstellung von n(pfeil hoch)4(pfeil hoch)-substituierten 1,4-diamino-2-nitrobenzolen |
GB8921792D0 (en) * | 1989-09-27 | 1989-11-08 | May & Baker Ltd | New compositions of matter |
US5220059A (en) * | 1990-04-19 | 1993-06-15 | Abbott Laboratories | Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids |
-
1992
- 1992-01-08 DE DE4200259A patent/DE4200259A1/de not_active Withdrawn
- 1992-12-10 ES ES92121028T patent/ES2084914T3/es not_active Expired - Lifetime
- 1992-12-10 DK DK92121028.2T patent/DK0554543T3/da active
- 1992-12-10 DE DE59205496T patent/DE59205496D1/de not_active Expired - Lifetime
- 1992-12-10 EP EP92121028A patent/EP0554543B1/de not_active Expired - Lifetime
- 1992-12-10 SG SG1996006604A patent/SG48046A1/en unknown
- 1992-12-10 AT AT92121028T patent/ATE134611T1/de active
-
1993
- 1993-01-04 CA CA002086654A patent/CA2086654C/en not_active Expired - Lifetime
- 1993-01-04 ZA ZA9311A patent/ZA9311B/xx unknown
- 1993-01-06 MX MX9300014A patent/MX9300014A/es unknown
- 1993-01-07 JP JP00105493A patent/JP3145220B2/ja not_active Expired - Fee Related
- 1993-01-08 US US08/002,458 patent/US5384330A/en not_active Expired - Lifetime
-
1996
- 1996-04-16 GR GR960401034T patent/GR3019653T3/el unknown
-
2011
- 2011-09-07 DE DE201112100044 patent/DE122011100044I1/de active Pending
- 2011-09-14 LU LU91869C patent/LU91869I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
ATE134611T1 (de) | 1996-03-15 |
CA2086654C (en) | 2003-09-23 |
JP3145220B2 (ja) | 2001-03-12 |
US5384330A (en) | 1995-01-24 |
CA2086654A1 (en) | 1993-07-09 |
EP0554543B1 (de) | 1996-02-28 |
DK0554543T3 (da) | 1996-03-18 |
DE59205496D1 (de) | 1996-04-04 |
EP0554543A3 (en) | 1993-10-27 |
SG48046A1 (en) | 1998-04-17 |
ZA9311B (en) | 1993-08-05 |
ES2084914T3 (es) | 1996-05-16 |
LU91869I2 (fr) | 2011-11-14 |
JPH05345752A (ja) | 1993-12-27 |
DE4200259A1 (de) | 1993-07-15 |
GR3019653T3 (en) | 1996-07-31 |
MX9300014A (es) | 1993-07-01 |
EP0554543A2 (de) | 1993-08-11 |
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