DE2539963C2 - - Google Patents

Info

Publication number
DE2539963C2
DE2539963C2 DE2539963A DE2539963A DE2539963C2 DE 2539963 C2 DE2539963 C2 DE 2539963C2 DE 2539963 A DE2539963 A DE 2539963A DE 2539963 A DE2539963 A DE 2539963A DE 2539963 C2 DE2539963 C2 DE 2539963C2
Authority
DE
Germany
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2539963A
Other versions
DE2539963A1 (de
Inventor
Howard John Richmond Va. Us Schaeffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10402412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE2539963(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE2539963A1 publication Critical patent/DE2539963A1/de
Application granted granted Critical
Publication of DE2539963C2 publication Critical patent/DE2539963C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
DE19752539963 1974-09-02 1975-09-02 Purinverbindungen und ihre salze, sowie verfahren zu ihrer herstellung Granted DE2539963A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB38278/74A GB1523865A (en) 1974-09-02 1974-09-02 Purine compunds and salts thereof

Publications (2)

Publication Number Publication Date
DE2539963A1 DE2539963A1 (de) 1976-03-18
DE2539963C2 true DE2539963C2 (de) 1987-01-22

Family

ID=10402412

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752539963 Granted DE2539963A1 (de) 1974-09-02 1975-09-02 Purinverbindungen und ihre salze, sowie verfahren zu ihrer herstellung

Country Status (35)

Country Link
US (3) US4360522A (de)
JP (1) JPS5154589A (de)
AR (4) AR220299A1 (de)
AT (1) AT354462B (de)
AU (1) AU503160B2 (de)
BE (1) BE833006A (de)
BG (4) BG26536A4 (de)
CA (1) CA1062257A (de)
CH (7) CH626363A5 (de)
CS (2) CS203093B2 (de)
CY (1) CY1033A (de)
DD (1) DD122092A5 (de)
DE (1) DE2539963A1 (de)
DK (1) DK146595C (de)
ES (3) ES440631A1 (de)
FI (1) FI60709C (de)
FR (1) FR2282892A1 (de)
GB (1) GB1523865A (de)
HK (1) HK84379A (de)
HU (1) HU176730B (de)
IE (1) IE42282B1 (de)
IL (1) IL48035A (de)
KE (1) KE3002A (de)
LU (1) LU73304A1 (de)
MC (1) MC1068A1 (de)
MY (1) MY8200191A (de)
NL (1) NL175061C (de)
NO (1) NO144216C (de)
NZ (1) NZ178556A (de)
RO (4) RO74275A (de)
SE (1) SE428562C (de)
SU (7) SU904523A3 (de)
YU (4) YU39947B (de)
ZA (1) ZA755574B (de)
ZM (1) ZM12875A1 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457091A (en) * 1992-09-24 1995-10-10 Hoechst Aktiengesellschaft N1-substituted 1H-1,2,3-triazolo[4,5,-D]pyrimidines, a process for their preparation and their use as antiviral agents
US8759510B2 (en) 2008-06-11 2014-06-24 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides

Families Citing this family (111)

* Cited by examiner, † Cited by third party
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US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
AU521577B2 (en) * 1977-02-24 1982-04-22 Wellcome Foundation Limited, The 9-hydroxyethoxymethyl guanine phosphates
US4287188A (en) 1977-02-24 1981-09-01 Burroughs Wellcome Co. Purine derivatives
KR830005852A (ko) * 1980-07-18 1983-09-14 미첼 페터 잭슨 피부와 점막의 비루스 감염치료에 적합한 국소치료제의 제조방법
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
AU547311B2 (en) * 1980-10-15 1985-10-17 Wellcome Foundation Limited, The Treating viral infections in fish
US4603219A (en) * 1981-05-21 1986-07-29 Syntex (U.S.A.) Inc. 1,3-dibenzyloxy-2-acetoxymethoxypropane, intermediate for 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
GB2104070B (en) * 1981-08-11 1985-08-14 Wellcome Found Purines
AU564576B2 (en) * 1981-09-24 1987-08-20 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Purine derivatives
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
EP0101441B1 (de) * 1982-02-12 1987-01-14 Syntex (U.S.A.) Inc. Antivirale zusammensetzungen
SE8203856D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine ii
SE8203855D0 (sv) * 1982-06-21 1982-06-21 Astra Laekemedel Ab Novel derivatives of guanine i
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
US4745119A (en) * 1982-10-14 1988-05-17 Burroughs Wellcome Co. Method for using purine derivatives
PL143208B1 (en) * 1982-10-14 1988-01-30 Wellcome Found Method of obtaining novel 2-amino-9-/2-hydroxyetoxymethyl/purine
US4649140A (en) * 1982-10-14 1987-03-10 Burroughs Wellcome Co. Purine derivatives
US5059604A (en) * 1982-10-14 1991-10-22 Burroughs Wellcome Co. 2-amino purine derivatives
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4612314A (en) * 1982-12-22 1986-09-16 Syntex (U.S.A.) Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
ES8403904A1 (es) * 1983-02-25 1984-04-01 Ind Farma Especial Un procedimiento para la preparacion de acicloguanosina.
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
ZA844744B (en) * 1983-06-24 1986-02-26 Merck & Co Inc Antiviral agents
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
JPS6094992A (ja) * 1983-10-28 1985-05-28 Sankyo Co Ltd グリゼオ−ル酸誘導体
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
ZA848080B (en) * 1983-10-31 1985-06-26 Warner Lambert Co Purine derivatives
US4918219A (en) * 1983-10-31 1990-04-17 Warner-Lambert Company Glycerine derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
US4617304A (en) * 1984-04-10 1986-10-14 Merck & Co., Inc. Purine derivatives
DK163985A (da) * 1984-04-13 1985-10-14 Wellcome Found Antivirale purinderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
EP0167385B1 (de) 1984-07-03 1992-03-18 The Wellcome Foundation Limited Antiviren-Verbindungen, Behandlung und Formulierungen
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US5683990A (en) * 1985-03-16 1997-11-04 Glaxo Wellcome Inc. Treatment of human viral infections
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
DE3667058D1 (en) 1985-05-02 1989-12-28 Wellcome Found Antiviral compounds
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
DE3529497A1 (de) * 1985-08-17 1987-02-26 Boehringer Mannheim Gmbh N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
IT1207507B (it) * 1985-10-21 1989-05-25 Baldacci Lab Spa Coniugato della 9-(2-idrossietossimetil)guanina con albumina umana lattosaminata, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.
ATE81778T1 (de) * 1986-10-06 1992-11-15 Univ Virginia Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe.
JPH01501478A (ja) * 1986-11-25 1989-05-25 インスティテュト　オルガニチェスコゴ　シンテザ　アカデミイ　ナウク　ラトビイスコイ　エスエスアール ９―置換グアニン
US4978655A (en) * 1986-12-17 1990-12-18 Yale University Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
US4829055A (en) * 1987-01-23 1989-05-09 Naficy Sadeque S Method of treatment for herpes infections of external tissues
US5565566A (en) * 1987-04-24 1996-10-15 Discovery Therapeutics, Inc. N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US4835104A (en) * 1987-06-16 1989-05-30 Ajinomoto Co., Inc., Patent & Licensing Department Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
US6306647B1 (en) 1987-06-16 2001-10-23 Ajinomoto Co., Inc. Process for producing and purifying 2′,3′-dideoxynucleosides, and process for producing 2′,3′-dideoxy-2′,3′-didehydronucleosides
GB8725939D0 (en) * 1987-11-05 1987-12-09 Wellcome Found Therapeutic compounds
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
CA1302887C (en) * 1987-11-24 1992-06-09 Yves Langelier Combination of acyclovir or a derivative thereof and bacitracin
JPH01121424U (de) * 1988-02-10 1989-08-17
US5164395A (en) * 1988-06-27 1992-11-17 Burroughs Wellcome Co. Antiviral acetyl pyridine derivative or said acetyl pyridine derivative in combination with acyclovir
GB8815241D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Antiviral combinations & compounds therefor
GB8816760D0 (en) * 1988-07-14 1988-08-17 Wellcome Found Therapeutic compounds
EP0366385B1 (de) * 1988-10-24 1993-06-09 The Wellcome Foundation Limited Guaninderivate mit antiviraler Wirkung und deren pharmazeutisch verträgliche Salze
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US5654286A (en) * 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
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TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
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AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
EP2752422B1 (de) 2010-03-31 2017-08-16 Gilead Pharmasset LLC Stereoselektive synthese von phosphorhaltigen wirkstoffen
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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4146715A (en) * 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457091A (en) * 1992-09-24 1995-10-10 Hoechst Aktiengesellschaft N1-substituted 1H-1,2,3-triazolo[4,5,-D]pyrimidines, a process for their preparation and their use as antiviral agents
US8759510B2 (en) 2008-06-11 2014-06-24 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US9045520B2 (en) 2008-12-23 2015-06-02 Gilead Pharmasset Llc Synthesis of purine nucleosides

Also Published As

Publication number Publication date
MY8200191A (en) 1982-12-31
DK392675A (da) 1976-03-03
AU8445975A (en) 1977-03-10
US4323573A (en) 1982-04-06
AR212914A1 (es) 1978-11-15
BG26389A3 (de) 1979-03-15
CY1033A (en) 1980-08-01
CA1062257A (en) 1979-09-11
US4294831A (en) 1981-10-13
RO74276A (ro) 1981-06-26
SU858569A3 (ru) 1981-08-23
YU119982A (en) 1982-08-31
CS203093B2 (en) 1981-02-27
IL48035A0 (en) 1975-11-25
NL175061B (nl) 1984-04-16
AR220885A1 (es) 1980-12-15
SU784777A3 (ru) 1980-11-30
CH629805A5 (de) 1982-05-14
FI752465A (de) 1976-03-03
CH623586A5 (de) 1981-06-15
SU686618A3 (ru) 1979-09-15
YU39947B (en) 1985-06-30
BG25094A3 (en) 1978-07-12
US4360522A (en) 1982-11-23
IL48035A (en) 1981-07-31
YU40080B (en) 1985-06-30
AR220508A1 (es) 1980-11-14
YU120082A (en) 1982-08-31
CH623587A5 (de) 1981-06-15
ZM12875A1 (en) 1977-09-21
IE42282L (en) 1976-03-02
DE2539963A1 (de) 1976-03-18
SU700064A3 (ru) 1979-11-25
CH629206A5 (de) 1982-04-15
ES440631A1 (es) 1977-06-16
CH628897A5 (de) 1982-03-31
ES455979A1 (es) 1978-01-16
RO74275A (ro) 1981-09-24
CH626364A5 (de) 1981-11-13
FI60709C (fi) 1982-03-10
GB1523865A (en) 1978-09-06
DK146595B (da) 1983-11-14
DK146595C (da) 1984-04-24
RO76939A (ro) 1981-06-22
NO144216C (no) 1981-07-15
NL175061C (nl) 1984-09-17
ATA676375A (de) 1979-06-15
HK84379A (en) 1979-12-14
YU120182A (en) 1982-08-31
SE7509675L (sv) 1976-03-03
BE833006A (fr) 1976-03-02
SE428562C (sv) 1985-08-20
NZ178556A (en) 1978-09-25
CH626363A5 (de) 1981-11-13
AU503160B2 (en) 1979-08-23
CS203092B2 (en) 1981-02-27
NO753009L (de) 1976-03-03
FI60709B (fi) 1981-11-30
JPS5154589A (en) 1976-05-13
ZA755574B (en) 1977-04-27
SU904523A3 (ru) 1982-02-07
KE3002A (en) 1979-12-14
DD122092A5 (de) 1976-09-12
BG24815A3 (en) 1978-05-12
IE42282B1 (en) 1980-07-16
HU176730B (en) 1981-04-28
JPS6147839B2 (de) 1986-10-21
BG26536A4 (de) 1979-04-12
RO74274A (ro) 1981-09-24
AT354462B (de) 1979-01-10
YU40079B (en) 1985-06-30
MC1068A1 (fr) 1976-05-21
NL7510342A (nl) 1976-03-04
ES455978A1 (es) 1978-01-16
SE428562B (sv) 1983-07-11
FR2282892B1 (de) 1980-04-25
LU73304A1 (de) 1976-08-13
SU799664A3 (ru) 1981-01-23
YU222075A (en) 1982-08-31
SU751325A3 (ru) 1980-07-23
NO144216B (no) 1981-04-06
AR220299A1 (es) 1980-10-31
FR2282892A1 (fr) 1976-03-26

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