DE2862289D1 - Intravascularly-administrable, magnetically-localizable biodegradable carrier and process for its preparation - Google Patents
Intravascularly-administrable, magnetically-localizable biodegradable carrier and process for its preparationInfo
- Publication number
- DE2862289D1 DE2862289D1 DE7878300208T DE2862289T DE2862289D1 DE 2862289 D1 DE2862289 D1 DE 2862289D1 DE 7878300208 T DE7878300208 T DE 7878300208T DE 2862289 T DE2862289 T DE 2862289T DE 2862289 D1 DE2862289 D1 DE 2862289D1
- Authority
- DE
- Germany
- Prior art keywords
- intravascularly
- administrable
- magnetically
- preparation
- biodegradable carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1866—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle the nanoparticle having a (super)(para)magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid
- A61K49/1869—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle the nanoparticle having a (super)(para)magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid coated or functionalised with a protein being an albumin, e.g. HSA, BSA, ovalbumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1887—Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
- G01N2333/765—Serum albumin, e.g. HSA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82081277A | 1977-08-01 | 1977-08-01 | |
US05/859,842 US4357259A (en) | 1977-08-01 | 1977-12-12 | Method of incorporating water-soluble heat-sensitive therapeutic agents in albumin microspheres |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2862289D1 true DE2862289D1 (en) | 1983-08-11 |
Family
ID=27124484
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE7878300208T Expired DE2862289D1 (en) | 1977-08-01 | 1978-07-28 | Intravascularly-administrable, magnetically-localizable biodegradable carrier and process for its preparation |
Country Status (7)
Country | Link |
---|---|
US (1) | US4357259A (de) |
EP (1) | EP0000667B1 (de) |
JP (1) | JPS5464626A (de) |
CA (1) | CA1109792A (de) |
DE (1) | DE2862289D1 (de) |
IE (1) | IE47305B1 (de) |
IT (1) | IT1097568B (de) |
Families Citing this family (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4450150A (en) * | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
JPS5651411A (en) * | 1979-10-04 | 1981-05-09 | Tetsuo Kato | Microcapsule preparation having magnetism |
US4331654A (en) * | 1980-06-13 | 1982-05-25 | Eli Lilly And Company | Magnetically-localizable, biodegradable lipid microspheres |
US4349530A (en) * | 1980-12-11 | 1982-09-14 | The Ohio State University | Implants, microbeads, microcapsules, preparation thereof and method of administering a biologically-active substance to an animal |
JPS57109714A (en) * | 1980-12-27 | 1982-07-08 | Taihoo Kogyo Kk | Magnetic fluid containing carcinostatic agent |
US4569836A (en) * | 1981-08-27 | 1986-02-11 | Gordon Robert T | Cancer treatment by intracellular hyperthermia |
EP0093757A1 (de) * | 1981-11-12 | 1983-11-16 | Ulf SCHRÖDER | Verfahren zur herstellung von magnetisch beeinflussbaren nanopartikeln für intravaskulare anwendung |
SE8201972L (sv) * | 1982-03-29 | 1983-09-30 | Gambro Lundia Ab | Magnetiskt paverkbara kristalliserade kolhydrat sferer eller partiklar att anvendas tillsammans med bioadsorberande material |
US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
DE3486448T2 (de) * | 1983-11-14 | 1997-10-09 | Columbia Lab Inc | Bioadhäsive Mittel |
US5225196A (en) * | 1983-11-14 | 1993-07-06 | Columbia Laboratories, Inc. | Bioadhesive compositions and methods of treatment therewith |
US4671954A (en) * | 1983-12-13 | 1987-06-09 | University Of Florida | Microspheres for incorporation of therapeutic substances and methods of preparation thereof |
GB2160312B (en) * | 1984-04-13 | 1987-09-16 | South African Inventions | Adjuvant for immunisation |
US4963367A (en) * | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
GB8422876D0 (en) * | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
JPS6157942U (de) * | 1984-09-19 | 1986-04-18 | ||
DE3508000A1 (de) * | 1985-03-04 | 1986-09-04 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Ferromagnetische partikel fuer die nmr-diagnostik |
JP2785025B2 (ja) * | 1985-03-19 | 1998-08-13 | ランデル・エル・ミルズ | 診断と選択的組織壊死を与える装置 |
US5223242A (en) * | 1985-11-05 | 1993-06-29 | The General Hospital Corporation | Negatively charged specific affinity reagents |
US4690130A (en) * | 1985-12-19 | 1987-09-01 | Mirell Stuart G | Electromagnetic therapy control system |
US4765980A (en) * | 1986-04-28 | 1988-08-23 | International Minerals & Chemical Corp. | Stabilized porcine growth hormone |
US5019372A (en) * | 1986-06-27 | 1991-05-28 | The Children's Medical Center Corporation | Magnetically modulated polymeric drug release system |
US5069216A (en) | 1986-07-03 | 1991-12-03 | Advanced Magnetics Inc. | Silanized biodegradable super paramagnetic metal oxides as contrast agents for imaging the gastrointestinal tract |
US4951675A (en) * | 1986-07-03 | 1990-08-28 | Advanced Magnetics, Incorporated | Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging |
US4770183A (en) * | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
US5219554A (en) | 1986-07-03 | 1993-06-15 | Advanced Magnetics, Inc. | Hydrated biodegradable superparamagnetic metal oxides |
US4925673A (en) * | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
USRE35862E (en) * | 1986-08-18 | 1998-07-28 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
DE3745075C2 (de) * | 1986-08-18 | 1997-04-30 | Emisphere Tech Inc | Mikroverkapselung für pharmakologische Mittel |
JP2654445B2 (ja) * | 1987-03-04 | 1997-09-17 | 株式会社富士薬品 | 天然アルブミンを担体とした医薬組成物及びその製法 |
US5690954A (en) * | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
DE3723310A1 (de) * | 1987-07-15 | 1989-01-26 | John Urquhart | Pharmazeutisches praeparat und verfahren zu seiner herstellung |
GR1000047B (el) * | 1988-02-04 | 1990-05-11 | Clinical Technologies Ass | Συστηματα χορηγησης φαρμακολογικων παραγοντων. |
CA1334936C (en) * | 1988-04-01 | 1995-03-28 | Walter Whitson-Fischman | Magnetically influenced homeopathic pharmaceutical formulations, methods of their preparation and methods of their administration |
US5162037A (en) * | 1988-04-01 | 1992-11-10 | Whitson Laboratories, Inc. | Magnetically influenced homeopathic pharmaceutical formulations, methods of their preparation and methods of their administration |
US5041292A (en) * | 1988-08-31 | 1991-08-20 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
US4983402A (en) * | 1989-02-24 | 1991-01-08 | Clinical Technologies Associates, Inc. | Orally administerable ANF |
US4976968A (en) * | 1989-02-24 | 1990-12-11 | Clinical Technologies Associates, Inc. | Anhydrous delivery systems for pharmacological agents |
ATE99546T1 (de) * | 1989-05-01 | 1994-01-15 | Alkermes Inc | Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen. |
US5271961A (en) * | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
AU642932B2 (en) * | 1989-11-06 | 1993-11-04 | Alkermes Controlled Therapeutics, Inc. | Protein microspheres and methods of using them |
ATE133856T1 (de) * | 1989-11-06 | 1996-02-15 | Alkermes Inc | Herstellungsverfahren für proteinmikrosphären |
FR2663224B1 (fr) * | 1990-06-14 | 1995-01-20 | Applicationes Farmaceuticas Sa | Forme galenique parenterale. |
US5443841A (en) * | 1992-06-15 | 1995-08-22 | Emisphere Technologies, Inc. | Proteinoid microspheres and methods for preparation and use thereof |
US5578323A (en) * | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US5541155A (en) * | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
US5447728A (en) * | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US5693338A (en) * | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
US6099856A (en) * | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
GB9026682D0 (en) * | 1990-12-07 | 1991-01-23 | Walker Bryan J | Lightweight aggregate |
US5616311A (en) * | 1991-01-15 | 1997-04-01 | Hemosphere, Inc. | Non-crosslinked protein particles for therapeutic and diagnostic use |
US6391343B1 (en) | 1991-01-15 | 2002-05-21 | Hemosphere, Inc. | Fibrinogen-coated particles for therapeutic use |
US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
US5792451A (en) * | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
US5811127A (en) * | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
US7425543B2 (en) * | 1992-11-16 | 2008-09-16 | The Corporation Of Mercer University | Microencapsulated materials and method of making same |
US5401516A (en) * | 1992-12-21 | 1995-03-28 | Emisphere Technologies, Inc. | Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof |
US6528067B1 (en) * | 1993-02-22 | 2003-03-04 | American Bioscience, Inc. | Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof |
US5981719A (en) * | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US5958457A (en) * | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
AU6819294A (en) * | 1993-04-22 | 1994-11-08 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
US5643957A (en) * | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5709861A (en) * | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
WO1997036480A1 (en) | 1996-03-29 | 1997-10-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5866536A (en) * | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5989539A (en) * | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
BR9604880A (pt) * | 1995-03-31 | 1998-05-19 | Emisphere Tech Inc | Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica |
US5650386A (en) * | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
US6090958A (en) * | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5965121A (en) * | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5820881A (en) * | 1995-04-28 | 1998-10-13 | Emisphere Technologies, Inc. | Microspheres of diamide-dicarboxylic acids |
US6051258A (en) * | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
US5667806A (en) * | 1995-06-07 | 1997-09-16 | Emisphere Technologies, Inc. | Spray drying method and apparatus |
US5824345A (en) * | 1995-06-07 | 1998-10-20 | Emisphere Technologies, Inc. | Fragrances and flavorants |
US5750147A (en) * | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
DE19528029B4 (de) | 1995-07-31 | 2008-01-10 | Chemagen Biopolymer-Technologie Aktiengesellschaft | Magnetische Polymerpartikel auf der Basis von Polyvinylalkohol, Verfahren für ihre Herstellung und Verwendung |
US6084112A (en) * | 1995-09-11 | 2000-07-04 | Emisphere Technologies, Inc. | Method for preparing ω-aminoalkanoic acid derivatives from cycloalkanones |
GB9600427D0 (en) * | 1996-01-10 | 1996-03-13 | Nycomed Imaging As | Contrast media |
HUP9901192A3 (en) | 1996-01-10 | 2000-02-28 | Amersham Health As | Contrast media |
CA2258264A1 (en) | 1996-06-14 | 1997-12-18 | Emisphere Technologies, Inc. | Microencapsulated fragrances and method for preparation |
US6017310A (en) * | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
US20070092563A1 (en) | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US6068600A (en) * | 1996-12-06 | 2000-05-30 | Quadrant Healthcare (Uk) Limited | Use of hollow microcapsules |
US5876710A (en) * | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US6060513A (en) * | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5879681A (en) * | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
US5804688A (en) * | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6313088B1 (en) | 1997-02-07 | 2001-11-06 | Emisphere Technologies, Inc. | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents |
US5939381A (en) * | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5990166A (en) * | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5863944A (en) * | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5962710A (en) * | 1997-05-09 | 1999-10-05 | Emisphere Technologies, Inc. | Method of preparing salicyloylamino acids |
AU8266298A (en) * | 1997-06-27 | 1999-01-19 | Vivorx Pharmaceuticals, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US6958148B1 (en) * | 1998-01-20 | 2005-10-25 | Pericor Science, Inc. | Linkage of agents to body tissue using microparticles and transglutaminase |
US20020082679A1 (en) * | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
US20030033007A1 (en) * | 2000-12-22 | 2003-02-13 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
US7083642B2 (en) | 2000-12-22 | 2006-08-01 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US7077859B2 (en) | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
US6471980B2 (en) | 2000-12-22 | 2002-10-29 | Avantec Vascular Corporation | Intravascular delivery of mycophenolic acid |
US6939375B2 (en) | 2000-12-22 | 2005-09-06 | Avantac Vascular Corporation | Apparatus and methods for controlled substance delivery from implanted prostheses |
AU2002305845B2 (en) | 2001-06-08 | 2006-03-30 | Ipsen Pharma S.A.S. | Somatostatin-dopamine chimeric analogs |
DE10224352A1 (de) * | 2002-06-01 | 2003-12-11 | Mueller Schulte Detlef | Thermosensitive Polymerträger mit veränderbarer physikalischer Struktur für die biochemische Analytik, Diagnostik und Therapie |
EP1668424A4 (de) * | 2003-09-12 | 2009-11-25 | Onkor Pharmaceuticals Inc | Magnetisch abzielbare partikel mit magnetischen komponenten und biokompatiblen polymeren für die ortsspezifische ablieferung biologisch aktiver wirkstoffe |
DE10350248A1 (de) * | 2003-10-28 | 2005-06-16 | Magnamedics Gmbh | Thermosensitive, biokompatible Polymerträger mit veränderbarer physikalischer Struktur für die Therapie, Diagnostik und Analytik |
US20080241082A1 (en) * | 2004-04-05 | 2008-10-02 | Lonza Inc. | Method for the Preparation of Cosmetic Emulsion |
US8287583B2 (en) | 2005-01-10 | 2012-10-16 | Taheri Laduca Llc | Apparatus and method for deploying an implantable device within the body |
US9526642B2 (en) | 2007-02-09 | 2016-12-27 | Taheri Laduca Llc | Vascular implants and methods of fabricating the same |
US8206545B2 (en) * | 2008-11-13 | 2012-06-26 | Lord Corporation | Magnetically curable composition and magnetic cure process |
US8210021B2 (en) * | 2009-01-16 | 2012-07-03 | Christopher Bryan Crass | Aromas kit |
WO2013084207A1 (pt) | 2011-12-07 | 2013-06-13 | Universidade Do Minho | Formulações micelares proteicas e respectivo método de produção |
NL2013527B1 (nl) * | 2014-09-26 | 2016-09-29 | Carbouw B V | Zekeringssysteem voor rolstoelen in voertuigen, en een werkwijze voor het ontgrendelen respectievelijk vergrendelen van een zekeringssysteem voor rolstoelen in voertuigen. |
GB2543604A (en) * | 2016-07-20 | 2017-04-26 | Ubicoat Ltd | Production of nanoscale powders of embedded nanoparticles |
WO2023068069A1 (en) | 2021-10-21 | 2023-04-27 | L'oreal | Composition comprising two polyglyceryl fatty acid esters and skincare active agent |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2671451A (en) * | 1952-06-16 | 1954-03-09 | Stephen J Bolger | Remedial pill |
NL108169C (de) * | 1957-01-30 | |||
US3057344A (en) * | 1957-05-21 | 1962-10-09 | Abella Carlos Alberto | Capsule for the study of the digestive tract and method of using the same |
FR1351358A (fr) * | 1958-12-22 | 1964-02-07 | Ncr Co | Procédé de formation de revêtements imperméables pour des matières en particules par séparation de phases liquides |
FR1468601A (fr) * | 1958-12-22 | 1967-02-10 | Ncr Co | Procédé de formation d'enduits protecteurs pour des particules solides et liquides |
GB929401A (en) * | 1958-12-22 | 1963-06-19 | Upjohn Co | Encapsulated emulsions and processes for their preparation |
US2989417A (en) * | 1958-12-24 | 1961-06-20 | Du Pont | Hardening of gelatin with titanium compounds |
NL246985A (de) * | 1958-12-31 | |||
US3137631A (en) * | 1959-12-01 | 1964-06-16 | Faberge Inc | Encapsulation in natural products |
BE634668A (de) * | 1962-07-11 | |||
NL280826A (de) * | 1962-07-11 | |||
US3474777A (en) * | 1966-02-10 | 1969-10-28 | Amp Inc | Method of administering therapeutic agents |
US3663687A (en) * | 1968-06-26 | 1972-05-16 | Minnesota Mining & Mfg | Biodegradable parenteral microspherules |
US3937668A (en) * | 1970-07-15 | 1976-02-10 | Ilse Zolle | Method for incorporating substances into protein microspheres |
US3725113A (en) * | 1970-12-17 | 1973-04-03 | Research Corp | Blood compatible microencapsulated detoxicants and method for making |
CA1077842A (en) * | 1975-10-09 | 1980-05-20 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
-
1977
- 1977-12-12 US US05/859,842 patent/US4357259A/en not_active Expired - Lifetime
-
1978
- 1978-07-28 EP EP78300208A patent/EP0000667B1/de not_active Expired
- 1978-07-28 DE DE7878300208T patent/DE2862289D1/de not_active Expired
- 1978-07-31 IE IE1540/78A patent/IE47305B1/en not_active IP Right Cessation
- 1978-07-31 CA CA308,471A patent/CA1109792A/en not_active Expired
- 1978-08-01 JP JP9446978A patent/JPS5464626A/ja active Granted
- 1978-08-01 IT IT26375/78A patent/IT1097568B/it active
Also Published As
Publication number | Publication date |
---|---|
IE47305B1 (en) | 1984-02-22 |
JPS5649889B2 (de) | 1981-11-25 |
IE781540L (en) | 1979-02-01 |
IT7826375A0 (it) | 1978-08-01 |
CA1109792A (en) | 1981-09-29 |
IT1097568B (it) | 1985-08-31 |
JPS5464626A (en) | 1979-05-24 |
EP0000667A1 (de) | 1979-02-07 |
EP0000667B1 (de) | 1983-07-06 |
US4357259A (en) | 1982-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE2862289D1 (en) | Intravascularly-administrable, magnetically-localizable biodegradable carrier and process for its preparation | |
GB2006708B (en) | Article carrier | |
JPS5432424A (en) | Process for preparing mononitrobenzene | |
YU211479A (en) | Process for obtaining 1-phenyl-2-azolyl-4,4-dimeethyl-1-pentene-3-ole | |
JPS53119813A (en) | Peroxycarboxylates and process for preparing same | |
HU179353B (en) | Process for preparing antibiotic acueatine aalpha,dalpha and dgamma | |
YU107378A (en) | Improved process for preparing urea | |
DE2860077D1 (en) | Cycloaminals, process for their preparation and their application | |
GB2003025B (en) | Carrier | |
JPS53132515A (en) | Novel sweeting llsuctose and process for preparing same | |
JPS53108967A (en) | 33aryll33heterylphtalides and process for preparing same | |
DE2861542D1 (en) | Polycarbodiimide-modified organopolysiloxanes, process for preparing same and their application | |
DE2861684D1 (en) | New n-amidino-3,5-diamino-6-substituted-2-pyrazinecarboxamides and process for preparing same | |
YU41015B (en) | Process for obtainig 2-formqequinoxaline -1,4-dioxyde cyanoacetylhydrazone | |
IL51877A0 (en) | Omega-nor-aromatic-13,14-dehydro-prostaglandins and process for their preparation | |
JPS5432419A (en) | Nnsubstituted alphaaamideketocarboxylate and process for preparing same | |
JPS5417388A (en) | Catalyst carrier | |
JPS53101359A (en) | Halogenbenzofuranonecarboxylate and process for preparing same | |
JPS53109000A (en) | Pyrazolopyridopyrimidines and process for preparing same | |
GB1554543A (en) | Process for preparing amino-phenyl-ureas and amino-carbanylates | |
JPS53101319A (en) | Arylenedioxyybissdiketone and process for preparing same | |
JPS53132529A (en) | Substituted nnphenylformamidoxim and process for preparing same | |
JPS5436209A (en) | Glycydyletheramine and process for preparing same | |
JPS53121732A (en) | Novel arylhexaflanoside and process for preparing same | |
JPS53121795A (en) | Pyrazolopyridopyrimidines and process for preparing same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8328 | Change in the person/name/address of the agent |
Free format text: SPOTT, G., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN |
|
8339 | Ceased/non-payment of the annual fee |