DE29824749U1 - Distale Schutzvorrichtung - Google Patents

Distale Schutzvorrichtung

Info

Publication number
DE29824749U1
DE29824749U1 DE29824749U DE29824749U DE29824749U1 DE 29824749 U1 DE29824749 U1 DE 29824749U1 DE 29824749 U DE29824749 U DE 29824749U DE 29824749 U DE29824749 U DE 29824749U DE 29824749 U1 DE29824749 U1 DE 29824749U1
Authority
DE
Germany
Prior art keywords
embolic
guidewire
guide wire
expandable member
trapping system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE29824749U
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Barbados
Original Assignee
Boston Scientific Ltd Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25204805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE29824749(U1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boston Scientific Ltd Barbados filed Critical Boston Scientific Ltd Barbados
Publication of DE29824749U1 publication Critical patent/DE29824749U1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2/013Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
    • AHUMAN NECESSITIES
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    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22031Gripping instruments, e.g. forceps, for removing or smashing calculi
    • AHUMAN NECESSITIES
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    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2/0105Open ended, i.e. legs gathered only at one side
    • AHUMAN NECESSITIES
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2/0108Both ends closed, i.e. legs gathered at both ends
    • AHUMAN NECESSITIES
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2/013Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
    • A61F2/014Retrograde blood flow filters, i.e. device inserted against the blood flow direction
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    • A61B2017/00535Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
    • A61B2017/00539Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated hydraulically
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
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    • A61B2017/22038Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A61B2017/22042Details of the tip of the guide wire
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    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A61B2017/22049Means for locking the guide wire in the catheter
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    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22051Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
    • A61B2017/22061Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation for spreading elements apart
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/221Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
    • A61B2017/2212Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions having a closed distal end, e.g. a loop
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2/013Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
    • A61F2002/015Stop means therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01Filters implantable into blood vessels
    • A61F2002/018Filters implantable into blood vessels made from tubes or sheets of material, e.g. by etching or laser-cutting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006Properties of materials and coating materials
    • A61F2002/30092Properties of materials and coating materials using shape memory or superelastic materials, e.g. nitinol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
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    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0006Rounded shapes, e.g. with rounded corners circular
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    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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    • A61F2230/0017Angular shapes
    • A61F2230/0021Angular shapes square
    • AHUMAN NECESSITIES
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    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
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    • AHUMAN NECESSITIES
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0073Quadric-shaped
    • A61F2230/0076Quadric-shaped ellipsoidal or ovoid
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    • A61M2025/09183Guide wires having specific characteristics at the distal tip having tools at the distal tip

Description

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Claims (23)

1. Embolieeinfangsystem zum Einführen in eine Gefäßanord­ nung zum Einfangen von Emboli in dem in der Gefäßanordnung fließenden Blut, wobei das Embolieeinfangsystem aufweist:
einen Führungsdraht mit einer Längsachse, der entlang mindestens eines Abschnitts ein Lumen definiert,
ein expandierbares Element, das mit einem distalen Ab­ schnitt des Führungsdrahts gekoppelt ist und einen Innenbe­ reich aufweist, der in Fluidverbindung mit dem Lumen im Führungsdraht steht, wobei das expandierbare Element so konfiguriert ist, daß es durch das Lumen Fluid entgegennimmt und sich dabei bezüglich des Führungsdrahts radial nach außen ausdehnt und daß Fluid aus seinem Innenbereich entfernt wird und es dabei bezüglich des Führungsdrahts radial nach innen zusammengefaltet wird, wobei ein beabstandeter Abschnitt des expandierbaren Elements im ausgedehnten Zustand des expandierbaren Elements radial nach außen vom Führungsdraht beabstandet ist, und
eine Embolieeinfangvorrichtung, die wirkungsmäßig mit dem expandierbaren Element gekoppelt und so konfiguriert ist, daß sie bei Ausdehnung des expandierbaren Elements bezüglich des Führungsdrahts radial nach außen entfaltet wird.
2. Embolieeinfangsystem nach Anspruch 1, wobei die Embolieeinfangvorrichtung ein Netz aufweist.
3. Embolieeinfangsystem nach Anspruch 1, wobei das expandierbare Element aufweist:
ein aufblasbares Element, das so konfiguriert ist, daß es, wenn es aufgeblasen ist, eine Form aufweist, die einen äußeren und einen inneren Umfangsbereich aufweist, wobei ein Abschnitt des inneren Umfangsbereichs von einer Außenfläche des Führungsdrahts beabstandet ist.
4. Embolieeinfangsystem nach Anspruch 3, wobei das auf­ blasbare Element so konfiguriert ist, daß mindestens ein Abschnitt des inneren Umfangsbereichs um die Außenfläche des Führungsdrahts gekrümmt und davon beabstandet ist.
5. Embolieeinfangsystem nach Anspruch 4, wobei das auf­ blasbare Element, wenn es aufgeblasen ist, mindestens einen Schleifenabschnitt bildet, der sich mindestens etwa 180° um den Führungsdraht erstreckt, wobei der Schleifenabschnitt von dem Führungsdraht beabstandet ist.
6. Embolieeinfangsystem nach Anspruch 5, wobei das auf­ blasbare Element, wenn es aufgeblasen ist, eine Wendel bildet, die um den Führungsdraht herum angeordnet und davon beabstandet ist.
7. Embolieeinfangsystem nach Anspruch 6, wobei das auf­ blasbare Element, wenn es aufgeblasen ist, eine im wesent­ lichen kegelförmige Schraubenform annimmt, die zum proximalen Ende des Führungsdrahts hin offen ist.
8. Embolieeinfangsystem nach Anspruch 7, wobei die Embolieeinfangvorrichtung ein Netz aufweist und wobei das aufblasbare Element, wenn es aufgeblasen ist, eine kegel­ förmige Schraubenform annimmt und wobei das Netz daran angebracht ist, um einen im wesentlichen kegelförmigen Korb zu bilden, der zum proximalen Ende des Führungsdrahts hin offen ist.
9. Embolieeinfangsystem nach Anspruch 1, wobei das expandierbare Element aufweist:
eine erste aufblasbare Verstrebung, die sich, wenn sie aufgeblasen ist, von einem distalen Ende von dieser dicht in der Nähe einer Außenfläche des Führungsdrahts zu einem proxi­ malen Ende von dieser, das radial nach außen von einer Außen­ fläche des Führungsdrahts beabstandet ist, erstreckt.
10. Embolieeinfangsystem nach Anspruch 9, wobei die Embolieeinfangvorrichtung ein Netz aufweist und wobei sich das Netz zwischen der ersten und der zweiten Verstrebung er­ streckt.
11. Embolieeinfangsystem nach Anspruch 10, weiter aufwei­ send:
mindestens eine zusätzliche aufblasbare Verstrebung, die in einem Winkelabstand von der ersten und der zweiten auf­ blasbaren Verstrebung um die Außenfläche des Führungsdrahts herum angeordnet ist, wobei sich das Netz zwischen der ersten und der zweiten aufblasbaren Verstrebung und der mindestens einen zusätzlichen aufblasbaren Verstrebung erstreckt.
12. Embolieeinfangsystem nach Anspruch 1, wobei das Fluid Gas aufweist.
13. Embolieeinfangsystem nach Anspruch 1, wobei die Embolieeinfangvorrichtung in einer zusammengefalteten Position vorgespannt ist, in der sie einen Außendurchmesser aufweist, der sich dem Außendurchmesser des Führungsdrahts nähert, und wobei die Embolieeinfangvorrichtung so konfiguriert ist, daß durch das Unter-Druck-Setzen des Fluids bewirkt wird, daß sich das expandierbare Element ausdehnt und die Embolieeinfangvorrichtung radial nach außen bezüglich des Führungsdrahts entfaltet.
14. Embolieeinfangsystem nach Anspruch 1, wobei die Embolieeinfangvorrichtung in einer entfalteten Position vorgespannt ist, in der sie radial nach außen bezüglich des Führungsdrahts ausgedehnt ist, und wobei durch das Entfernen von Fluid aus dem expandierbaren Element bewirkt wird, daß sich die Embolieeinfangvorrichtung in eine zurückgezogene Position bewegt, in der die Embolieeinfangvorrichtung einen Außendurchmesser aufweist, der sich dem Außendurchmesser des Führungsdrahts nähert.
15. Dilatationssystem, aufweisend:
eine Dilatationsvorrichtung, die dafür konfiguriert ist, eine Beschränkung in einem Blutgefäß zu zerlegen, und
ein Embolieeinfangsystem, das innerhalb des Blutgefäßes bezüglich der Dilatationsvorrichtung in Längsrichtung beweg­ lich ist, wobei das Embolieeinfangsystem aufweist:
einen Führungsdraht mit einer Längsachse, der entlang mindestens eines Abschnitts ein Lumen definiert,
ein expandierbares Element, das mit einem distalen Ab­ schnitt des Führungsdrahts gekoppelt ist und einen Innenbereich aufweist, der in Fluidverbindung mit dem Lumen im Führungsdraht steht, wobei das expandierbare Element so konfiguriert ist, daß es durch das Lumen Fluid entgegennimmt und sich dabei bezüglich des Führungsdrahts radial nach außen ausdehnt und daß Fluid aus seinem Innenbereich entfernt wird und es dabei bezüglich des Führungsdrahts radial nach innen zusammengefaltet wird, wobei ein beabstandeter Abschnitt des expandierbaren Elements im ausgedehnten Zustand des expandierbaren Elements radial nach außen vom Führungsdraht beabstandet ist, und
eine Embolieeinfangvorrichtung, die wirkungsmäßig mit dem expandierbaren Element gekoppelt ist und so konfiguriert ist, daß sie bei der Ausdehnung des expandierbaren Elements bezüg­ lich des Führungsdrahts radial nach außen entfaltet wird.
16. Embolieschutzvorrichtung mit
einem langgestreckten Element mit einem proximalen Ende und einem distalen Ende und einem sich in Querrichtung erstreckenden Vorsprung,
einem rohrförmigen Element, das um das langgestreckte Element herum angeordnet ist, wobei mindestens ein Abschnitt des rohrförmigen Elements über dem langgestreckten Element gleitfähig ist, und
einem porösen Element, das an dem rohrförmigen Element angebracht ist,
wobei der Vorsprung die Gleitbewegung des rohrförmigen Elements über dem langgestreckten Element begrenzt.
17. Embolieschutzvorrichtung nach Anspruch 16, wobei das rohrförmige Element mehrere damit verbundene Verstrebungen aufweist.
18. Embolieschutzvorrichtung nach Anspruch 17, wobei die Verstrebungen eine NiTi-Legierung aufweisen.
19. Embolieschutzvorrichtung nach Anspruch 18, wobei die NiTi-Legierung Nitinol aufweist.
20. Embolieschutzvorrichtung nach Anspruch 17, wobei die Verstrebungen zwischen einer ersten Position und einer ausge­ dehnten Position beweglich sind.
21. Embolieschutzvorrichtung nach Anspruch 20, wobei die poröse Membran an den Verstrebungen angebracht ist.
22. Embolieschutzvorrichtung nach Anspruch 21, wobei sich die poröse Membran aus einer zusammengefalteten in eine ausgedehnte Position bewegt, wenn sich die Verstrebungen aus der ersten Position in die ausgedehnte Position bewegen.
23. Embolieschutzvorrichtung nach Anspruch 22, wobei Blut und Emboli durch einen proximalen Abschnitt der Verstrebungen hindurchtreten können, Blut durch die poröse Membran fließen kann und Emboli durch die poröse Membran festgehalten werden können, wenn sich die poröse Membran in der ausgedehnten Position befindet.
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US20040106944A1 (en) 2004-06-03
DE69828946D1 (de) 2005-03-17
EP1905365B1 (de) 2010-10-06
ATE288704T1 (de) 2005-02-15
EP0923344A1 (de) 1999-06-23
US20030130687A1 (en) 2003-07-10
US5814064A (en) 1998-09-29
DE69838800T2 (de) 2008-04-30
US20030130686A1 (en) 2003-07-10
US6053932A (en) 2000-04-25
US6872216B2 (en) 2005-03-29
EP1905365A1 (de) 2008-04-02
WO1998038920A1 (en) 1998-09-11
US20030130688A1 (en) 2003-07-10
US20030083693A1 (en) 2003-05-01
EP0923344A4 (de) 2003-07-23
EP0923344B1 (de) 2005-02-09
US20030130685A1 (en) 2003-07-10
US6001118A (en) 1999-12-14
EP1510177B1 (de) 2007-11-28
DE69828946T2 (de) 2006-05-11
US20050119691A1 (en) 2005-06-02
US6663652B2 (en) 2003-12-16
DE69841933D1 (de) 2010-11-18
US6245089B1 (en) 2001-06-12
EP1510177A1 (de) 2005-03-02
DE69838800D1 (de) 2008-01-10
US20010044632A1 (en) 2001-11-22
US20050101986A1 (en) 2005-05-12
ATE483411T1 (de) 2010-10-15

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