DE29909208U1 - Neue Effektoren von Dipeptidylpeptidase IV - Google Patents
Neue Effektoren von Dipeptidylpeptidase IVInfo
- Publication number
- DE29909208U1 DE29909208U1 DE29909208U DE29909208U DE29909208U1 DE 29909208 U1 DE29909208 U1 DE 29909208U1 DE 29909208 U DE29909208 U DE 29909208U DE 29909208 U DE29909208 U DE 29909208U DE 29909208 U1 DE29909208 U1 DE 29909208U1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical composition
- composition according
- valyl
- diabetes mellitus
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Description
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Claims (11)
1. Valyl-Thiazolidid, Valyl-Pyrrolidid und deren Salze.
2. Verbindung nach Anspruch 1, dadurch gekennzeichnet, daß die
Salze organische Salze wie Acetate, Succinate, Tartrate oder
Fumarate oder anorganische Säurereste wie Phosphate oder Sul
fate sind.
3. Verbindung nach einem der vorstehenden Ansprüche, dadurch
gekennzeichnet, daß das molare Verhältnis von Valyl-Thiazoli
didkomponente oder Valyl-Pyrrolididkomponente zur Salzkompo
nente 1 : 1 oder 2 : 1 beträgt.
5. Pharmazeutische Zusammensetzung, die mindestens eine Ver
bindung nach einem der vorstehenden Ansprüche gegebenenfalls
in Kombination mit einem oder mehreren pharmazeutisch akzepta
blen Trägern und/oder Lösungsmitteln enthält.
6. Pharmazeutische Zusammensetzung nach Anspruch 5, dadurch
gekennzeichnet, daß es sich um einen Träger für parenterale
oder enterale Formulierungen handelt.
7. Pharmazeutische Zusammensetzung nach Anspruch 6, dadurch
gekennzeichnet, daß sie in einer Formulierung zur oralen Ver
abreichung vorliegt.
8. Pharmazeutische Zusammensetzung nach einem der Ansprüche 5
bis 7, dadurch gekennzeichnet, daß sie zusätzlich einen hypo
glykämisch wirkenden Wirkstoff enthält.
9. Pharmazeutische Zusammensetzung nach einem der Ansprüche 5
bis,8 zur Aktivitätsminderung von Dipeptidylpeptidase IV bzw.
von Dipeptidylpeptidase IV analogen Enzymaktivitäten.
10. Pharmazeutische Zusammensetzung nach einem der Ansprüche 5
bis 8 zur Senkung des Blutzuckerspiegels unter die für Hyper
glykämie charakteristische Glukosekonzentration im Serum eines
Säugers.
11. Pharmazeutische Zusammensetzung nach einem der Ansprüche 5
bis 8 zur oralen Behandlung von mit Diabetes mellitus im Zu
sammenhang stehenden Stoffwechselerkrankungen.
12. Pharmazeutische Zusammensetzung nach einem der Ansprüche 5
bis 8 zur Behandlung von beeinträchtigter Glukosetoleranz,
Glukosurie, Hyperlipidämie, metabolischen Azidosen, Diabetes
mellitus, diabetischer Neuropathie und Nephropathie sowie von
durch Diabetes mellitus verursachten Folgeerkrankungen von
Säugern.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE29909208U DE29909208U1 (de) | 1998-05-28 | 1999-05-28 | Neue Effektoren von Dipeptidylpeptidase IV |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823831A DE19823831A1 (de) | 1998-05-28 | 1998-05-28 | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
DE29909208U DE29909208U1 (de) | 1998-05-28 | 1999-05-28 | Neue Effektoren von Dipeptidylpeptidase IV |
Publications (1)
Publication Number | Publication Date |
---|---|
DE29909208U1 true DE29909208U1 (de) | 1999-09-09 |
Family
ID=7869159
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19823831A Withdrawn DE19823831A1 (de) | 1998-05-28 | 1998-05-28 | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
DE59911670T Expired - Fee Related DE59911670D1 (de) | 1998-05-28 | 1999-05-28 | Glutamin-Thiazolidide und -Pyrrolidide sowie ihre Verwendung als Dipeptidylpeptidase IV Inhibitoren |
DE59913840T Expired - Fee Related DE59913840D1 (de) | 1998-05-28 | 1999-05-28 | Effektoren von Dipeptidylpeptidase IV |
DE29909210U Expired - Lifetime DE29909210U1 (de) | 1998-05-28 | 1999-05-28 | Neue Effektoren von Dipeptidylpeptidase IV |
DE29909211U Expired - Lifetime DE29909211U1 (de) | 1998-05-28 | 1999-05-28 | Neue Effektoren von Dipeptidylpeptidase IV |
DE59913784T Expired - Fee Related DE59913784D1 (de) | 1998-05-28 | 1999-05-28 | Verwendung von Thiazolidinderivaten als antihyperglykämische Mittel |
DE59904100T Expired - Lifetime DE59904100D1 (de) | 1998-05-28 | 1999-05-28 | Neue effektoren von dipeptidylpeptidase iv |
DE59910083T Expired - Fee Related DE59910083D1 (de) | 1998-05-28 | 1999-05-28 | Verwendung von Thiazolidin- oder Pyrrolidinderivaten von Aminosäuren als antihyperglykämische Mittel |
DE59910084T Expired - Fee Related DE59910084D1 (de) | 1998-05-28 | 1999-05-28 | Organische Salze von Isoleucyl-Thiazolidin und -Pyrrolidin und ihre Verwendung als Dipeptidylpeptidase-Inhibitoren |
DE29909208U Expired - Lifetime DE29909208U1 (de) | 1998-05-28 | 1999-05-28 | Neue Effektoren von Dipeptidylpeptidase IV |
Family Applications Before (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19823831A Withdrawn DE19823831A1 (de) | 1998-05-28 | 1998-05-28 | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
DE59911670T Expired - Fee Related DE59911670D1 (de) | 1998-05-28 | 1999-05-28 | Glutamin-Thiazolidide und -Pyrrolidide sowie ihre Verwendung als Dipeptidylpeptidase IV Inhibitoren |
DE59913840T Expired - Fee Related DE59913840D1 (de) | 1998-05-28 | 1999-05-28 | Effektoren von Dipeptidylpeptidase IV |
DE29909210U Expired - Lifetime DE29909210U1 (de) | 1998-05-28 | 1999-05-28 | Neue Effektoren von Dipeptidylpeptidase IV |
DE29909211U Expired - Lifetime DE29909211U1 (de) | 1998-05-28 | 1999-05-28 | Neue Effektoren von Dipeptidylpeptidase IV |
DE59913784T Expired - Fee Related DE59913784D1 (de) | 1998-05-28 | 1999-05-28 | Verwendung von Thiazolidinderivaten als antihyperglykämische Mittel |
DE59904100T Expired - Lifetime DE59904100D1 (de) | 1998-05-28 | 1999-05-28 | Neue effektoren von dipeptidylpeptidase iv |
DE59910083T Expired - Fee Related DE59910083D1 (de) | 1998-05-28 | 1999-05-28 | Verwendung von Thiazolidin- oder Pyrrolidinderivaten von Aminosäuren als antihyperglykämische Mittel |
DE59910084T Expired - Fee Related DE59910084D1 (de) | 1998-05-28 | 1999-05-28 | Organische Salze von Isoleucyl-Thiazolidin und -Pyrrolidin und ihre Verwendung als Dipeptidylpeptidase-Inhibitoren |
Country Status (24)
Country | Link |
---|---|
US (4) | US6548481B1 (de) |
EP (6) | EP1428533B1 (de) |
JP (1) | JP2002516318A (de) |
KR (2) | KR100630258B1 (de) |
CN (4) | CN1637018A (de) |
AT (6) | ATE289598T1 (de) |
AU (1) | AU764262B2 (de) |
BR (1) | BR9910758A (de) |
CA (1) | CA2333603C (de) |
DE (10) | DE19823831A1 (de) |
DK (2) | DK1214936T3 (de) |
ES (5) | ES2223981T3 (de) |
HK (3) | HK1033316A1 (de) |
HU (1) | HUP0102001A3 (de) |
IL (3) | IL139862A0 (de) |
IS (3) | IS5728A (de) |
NO (1) | NO317989B1 (de) |
NZ (2) | NZ525799A (de) |
PL (1) | PL344403A1 (de) |
PT (2) | PT1214936E (de) |
RU (3) | RU2227800C2 (de) |
SI (2) | SI1082314T1 (de) |
UA (1) | UA54599C2 (de) |
WO (1) | WO1999061431A1 (de) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001062266A2 (en) * | 2000-02-25 | 2001-08-30 | Novo Nordisk A/S | Use of dpp-iv inhibitors for the treatment of diabetes |
WO2002083109A1 (en) * | 2001-04-11 | 2002-10-24 | Ferring Bv | Treatment of type 2 diabetes with inhibitors of dipeptidyl peptidase iv |
Families Citing this family (240)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020006899A1 (en) * | 1998-10-06 | 2002-01-17 | Pospisilik Andrew J. | Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals |
ES2285785T3 (es) * | 1997-09-29 | 2007-11-16 | Point Therapeutics, Inc. | Estimulacion de celulas hematopoyeticas in vitro. |
DE19823831A1 (de) * | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
DE19834591A1 (de) * | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Verfahren zur Steigerung des Blutglukosespiegels in Säugern |
US6979697B1 (en) | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
US20030176357A1 (en) * | 1998-10-06 | 2003-09-18 | Pospisilik Andrew J. | Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels |
WO2000053171A1 (en) * | 1999-03-05 | 2000-09-14 | Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. | Use of metformin in the preparation of pharmaceutical compositions capable of inhibiting the enzyme dipeptidyl peptidase iv |
US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
US6890904B1 (en) * | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
DE19940130A1 (de) | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
AU2268301A (en) * | 1999-12-17 | 2001-06-25 | Versicor Inc | Novel urea compounds, compositions and methods of use and preparation |
BRPI0107715B8 (pt) * | 2000-01-21 | 2021-05-25 | Novartis Ag | produto farmacêutico compreendendo um inibidor de dipeptidilpeptidase-iv e metformina, bem como usos do dito produto farmacêutico e do inibidor de dipeptidilpeptidase-iv |
US20080076811A1 (en) * | 2000-01-21 | 2008-03-27 | Bork Balkan | Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents |
EP2266665B1 (de) * | 2000-03-31 | 2016-05-11 | Royalty Pharma Collection Trust | Verbesserung der Aktivität der Inselzellen bei Diabetes Mellitus und dessen Prävention |
GB0010183D0 (en) | 2000-04-26 | 2000-06-14 | Ferring Bv | Inhibitors of dipeptidyl peptidase IV |
GB0014969D0 (en) | 2000-06-19 | 2000-08-09 | Smithkline Beecham Plc | Novel method of treatment |
US7078397B2 (en) | 2000-06-19 | 2006-07-18 | Smithkline Beecham Corporation | Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus |
NZ524618A (en) | 2000-08-10 | 2004-08-27 | Mitsubishi Pharma Corp | Proline derivatives and use thereof as drugs |
CA2424475A1 (en) * | 2000-10-27 | 2002-05-02 | Probiodrug Ag | Method for the treatment of neurological and neuropsychological disorders |
US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
EP1891948A1 (de) * | 2000-10-27 | 2008-02-27 | Probiodrug AG | Behandlung von neurologischen und neuropsychologischen Störungen |
JPWO2002051836A1 (ja) * | 2000-12-27 | 2004-04-22 | 協和醗酵工業株式会社 | ジペプチジルペプチダーゼ−iv阻害剤 |
SI1757606T1 (sl) * | 2001-02-24 | 2009-10-31 | Boehringer Ingelheim Pharma | Ksantinski derivati za uporabo kot zdravila kot tudi postopek za njihovo pripravo |
US20070293426A1 (en) * | 2001-04-02 | 2007-12-20 | Hans-Ulrich Demuth | Methods for improving islet signaling in diabetes mellitus and for its prevention |
US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
HUP0600232A2 (en) | 2001-04-11 | 2006-08-28 | Bristol Myers Squibb Co | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
US6944925B2 (en) * | 2001-06-13 | 2005-09-20 | Ttx Company | Articulated connector reconditioning process and apparatuses |
CN1321682C (zh) * | 2001-06-27 | 2007-06-20 | 前体生物药物股份有限公司 | 新的二肽基肽酶iv抑制剂和它们作为抗癌药的用途 |
US7196201B2 (en) | 2001-06-27 | 2007-03-27 | Smithkline Beecham Corporation | Pyrrolidines as dipeptidyl peptidase inhibitors |
DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
US7132443B2 (en) * | 2001-06-27 | 2006-11-07 | Smithklinebeecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
EP1399433B1 (de) | 2001-06-27 | 2007-08-22 | Smithkline Beecham Corporation | Fluoropyrrolidine als dipeptidyl-peptidase inhibitoren |
UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
WO2003015768A2 (en) * | 2001-08-16 | 2003-02-27 | Probiodrug Ag | Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades |
US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
TWI246510B (en) | 2001-09-14 | 2006-01-01 | Mitsubishi Pharma Corp | Thiazolidine derivatives and pharmaceutical uses thereof |
US7238671B2 (en) | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
GEP20063908B (en) | 2001-10-18 | 2006-08-25 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
GB0125446D0 (en) * | 2001-10-23 | 2001-12-12 | Ferring Bv | Novel anti-diabetic agents |
DE60304911D1 (de) | 2002-02-25 | 2006-06-08 | Eisai Co Ltd | Xanthin-Derivate als DPP-IV-Inhibitoren |
CN1622941A (zh) * | 2002-02-28 | 2005-06-01 | 普罗西迪恩有限公司 | 基于谷氨酰胺酰基的dpiv抑制剂 |
EP1695970A1 (de) * | 2002-02-28 | 2006-08-30 | Prosidion Limited | Peptide geeignet für die kompetitive Modulierung der DipeptidylpeptidaseIV-Katalyse |
US20030232761A1 (en) * | 2002-03-28 | 2003-12-18 | Hinke Simon A. | Novel analogues of glucose-dependent insulinotropic polypeptide |
US7057046B2 (en) | 2002-05-20 | 2006-06-06 | Bristol-Myers Squibb Company | Lactam glycogen phosphorylase inhibitors and method of use |
US6710040B1 (en) | 2002-06-04 | 2004-03-23 | Pfizer Inc. | Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors |
AU2002331226A1 (en) * | 2002-08-09 | 2004-03-11 | Prosidion Ltd. | Methods for improving islet signaling in diabetes mellitus and for its prevention |
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WO2001062266A2 (en) * | 2000-02-25 | 2001-08-30 | Novo Nordisk A/S | Use of dpp-iv inhibitors for the treatment of diabetes |
WO2001062266A3 (en) * | 2000-02-25 | 2002-05-02 | Novo Nordisk As | Use of dpp-iv inhibitors for the treatment of diabetes |
WO2002083109A1 (en) * | 2001-04-11 | 2002-10-24 | Ferring Bv | Treatment of type 2 diabetes with inhibitors of dipeptidyl peptidase iv |
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