DE3172087D1 - Material for filling and healing wounds, and method for its preparation - Google Patents

Material for filling and healing wounds, and method for its preparation

Info

Publication number
DE3172087D1
DE3172087D1 DE8181110421T DE3172087T DE3172087D1 DE 3172087 D1 DE3172087 D1 DE 3172087D1 DE 8181110421 T DE8181110421 T DE 8181110421T DE 3172087 T DE3172087 T DE 3172087T DE 3172087 D1 DE3172087 D1 DE 3172087D1
Authority
DE
Germany
Prior art keywords
mixture
thrombin
fibrinogen
substances
filling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181110421T
Other languages
English (en)
Inventor
Eberhard Prof Dr Zimmermann
Ulrich Dr Schiele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nycomed Arzneimittel GmbH
Original Assignee
Hormon-Chemie Munchen GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hormon-Chemie Munchen GmbH filed Critical Hormon-Chemie Munchen GmbH
Application granted granted Critical
Publication of DE3172087D1 publication Critical patent/DE3172087D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/102—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S602/00—Surgery: splint, brace, or bandage
    • Y10S602/90—Method of making bandage structure
DE8181110421T 1981-02-16 1981-12-14 Material for filling and healing wounds, and method for its preparation Expired DE3172087D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813105624 DE3105624A1 (de) 1981-02-16 1981-02-16 Material zum abdichten und heilen von wunden

Publications (1)

Publication Number Publication Date
DE3172087D1 true DE3172087D1 (en) 1985-10-03

Family

ID=6124998

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19813105624 Withdrawn DE3105624A1 (de) 1981-02-16 1981-02-16 Material zum abdichten und heilen von wunden
DE2001199040 Active DE10199040I2 (de) 1981-02-16 1981-12-14 Material zum Abdichten und Heilen von Wunden und Verfahren zu dessen Herstellung
DE8181110421T Expired DE3172087D1 (en) 1981-02-16 1981-12-14 Material for filling and healing wounds, and method for its preparation

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE19813105624 Withdrawn DE3105624A1 (de) 1981-02-16 1981-02-16 Material zum abdichten und heilen von wunden
DE2001199040 Active DE10199040I2 (de) 1981-02-16 1981-12-14 Material zum Abdichten und Heilen von Wunden und Verfahren zu dessen Herstellung

Country Status (12)

Country Link
US (1) US4453939A (de)
EP (1) EP0059265B1 (de)
JP (1) JPS57153645A (de)
AT (1) ATE15143T1 (de)
CA (1) CA1181689A (de)
CS (1) CS241502B2 (de)
DD (1) DD206936A1 (de)
DE (3) DE3105624A1 (de)
EG (1) EG15603A (de)
GR (1) GR75042B (de)
HU (1) HU183823B (de)
ZA (1) ZA82123B (de)

Families Citing this family (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068047B1 (de) * 1981-06-25 1986-07-23 Serapharm GmbH & Co. KG Angereichertes Plasmaderivat zur Unterstützung von Wundverschluss und Wundheilung
DE3212412C2 (de) * 1982-04-02 1986-01-02 Dr. Ruhland Nachf. GmbH, 8425 Neustadt Gewebeverklebbare kollagene Wundauflage
DE3214337C2 (de) * 1982-04-19 1984-04-26 Serapharm - Michael Stroetmann, 4400 Münster Resorbierbares Flachmaterial zum Abdichten und Heilen von Wunden und Verfahren zu dessen Herstellung
JPS58180162A (ja) * 1982-04-19 1983-10-21 株式会社高研 抗血栓性医用材料
SE446688C (sv) * 1982-09-14 1989-08-01 Magnus Hoeoek Medel foer avlaegsnande av mikroorganismer fraan vaevnader, vilket bestaar av ett protein som kan bindas till mikroorganismerna
US4515637A (en) * 1983-11-16 1985-05-07 Seton Company Collagen-thrombin compositions
US4606910A (en) * 1984-06-28 1986-08-19 Interface Biomedical Laboratories Composite hemostatic article including a hemostatic agent onlay and methods for preparing the same
US4738849A (en) * 1984-06-28 1988-04-19 Interface Biomedical Laboratories Corp. Composite medical articles for application to wounds and method for producing same
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
JPH0617311B2 (ja) * 1985-01-24 1994-03-09 株式会社生体科学研究所 正常組織生物活性亢進剤
JPS62205711A (ja) * 1986-03-03 1987-09-10 株式会社クボタ 田植機の植付装置姿勢制御構造
US4894328A (en) * 1986-03-26 1990-01-16 Board Of Regents, The University Of Texas System Immunodiagnostic test for syphilis and other treponemal infections
CA1294546C (en) * 1986-04-23 1992-01-21 John S. Sundsmo Wound healing composition containing collagen
US4760131A (en) * 1986-04-23 1988-07-26 Collagen Corporation Wound-healing composition
WO1987007153A1 (en) * 1986-05-29 1987-12-03 Interface Biomedical Laboratories Corporation Composite hemostatic article including a hemostatic agent onlay and methods for preparing the same
DE3622642A1 (de) * 1986-07-05 1988-01-14 Behringwerke Ag Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
DK475386D0 (da) 1986-10-03 1986-10-03 Weis Fogh Ulla Sivertsen Fremgangsmaade og apparat til fremstilling af biologiske stoffer
JPS649514U (de) * 1987-07-03 1989-01-19
AT407834B (de) * 1987-10-08 2001-06-25 Aventis Behring Gmbh Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
JPH0199565A (ja) * 1987-10-12 1989-04-18 Green Cross Corp:The フィブリン糊調製用キット
US4961707A (en) * 1987-12-22 1990-10-09 University Of Florida Guided periodontal tissue regeneration
US4973466A (en) * 1988-06-21 1990-11-27 Chiron Ophthalmics, Inc. Wound-healing dressings and methods
US4863668A (en) * 1988-09-22 1989-09-05 University Of Utah Method of forming fibrin-collagen nerve and body tissue repair material
US5700479A (en) * 1988-12-23 1997-12-23 Guidor Ab Surgical element and method for selective tissue regeneration
US5196185A (en) * 1989-09-11 1993-03-23 Micro-Collagen Pharmaceutics, Ltd. Collagen-based wound dressing and method for applying same
US5030215A (en) * 1990-01-03 1991-07-09 Cryolife, Inc. Preparation of fibrinogen/factor XIII precipitate
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US7196054B1 (en) 1990-11-27 2007-03-27 The American National Red Cross Methods for treating wound tissue and forming a supplemented fibrin matrix
US6197325B1 (en) * 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US5219895A (en) * 1991-01-29 1993-06-15 Autogenesis Technologies, Inc. Collagen-based adhesives and sealants and methods of preparation and use thereof
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
IL105529A0 (en) * 1992-05-01 1993-08-18 Amgen Inc Collagen-containing sponges as drug delivery for proteins
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
US5942278A (en) * 1993-03-31 1999-08-24 Nycomed Arzneimittel Gmbh Process for the production of a material for sealing and healing wounds
AT502891B1 (de) * 1993-03-31 2008-04-15 Nycomed Austria Gmbh Verfahren und vorrichtung zum gleichmässigen auftragen einer suspension auf einen kollagenträger
AT410754B (de) * 1993-03-31 2003-07-25 Nycomed Austria Gmbh Vorrichtung zum gleichmässigen auftragen einer suspension auf einen kollagenträger
US6177126B1 (en) 1993-03-31 2001-01-23 Nycomed Arzneimittel Gmbh Process for the production of a material for sealing and healing wounds
DE4313724C2 (de) * 1993-04-27 2003-12-11 Nycomed Austria Gmbh Linz Vorrichtung zum gleichmäßigen Auftragen einer Suspension auf einen Kollagenträger
EP0726749B1 (de) * 1993-11-03 2004-08-11 Clarion Pharmaceuticals, Inc. Hämostatisches pflaster
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US5660873A (en) * 1994-09-09 1997-08-26 Bioseal, Limited Liability Corporaton Coating intraluminal stents
US5585007A (en) 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US5643192A (en) * 1995-04-06 1997-07-01 Hamilton Civic Hospitals Research Development, Inc. Autologous fibrin glue and methods for its preparation and use
US20030105007A1 (en) * 1995-06-07 2003-06-05 Andre Beaulieu PDGF-betabeta and fibronectin combined in a solid wound dressing for the treatment of wounds
DE19521324C1 (de) * 1995-06-12 1996-10-31 Immuno Ag Gewebeklebstoff und Verwendung desselben als Hämostyptikum
CZ292389B6 (cs) * 1995-12-13 2003-09-17 Nycomed Austria Gmbh Nástroj pro aplikaci chirurgického materiálu
CA2245585A1 (en) * 1996-02-06 1997-08-14 David P. Kosow Composition for sealing wounds
GB2311027B (en) 1996-03-15 1999-10-27 Johnson & Johnson Medical Coated bioabsorbable beads for wound treatment
CA2251475C (en) * 1996-04-04 2006-09-05 Immuno Aktiengesellschaft Hemostatic sponge based on collagen
WO2000062828A1 (en) * 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
EP0959795A4 (de) * 1996-10-16 2000-01-19 Fusion Medical Technologies Filme mit verbesserten eigenschaften und ein verfahren zu deren herstellung undgebrauch
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
US6194378B1 (en) 1998-02-18 2001-02-27 The Research Foundation Of State University Of New York Fibronectin peptides-based extracellular matrix for wound healing
WO1999042084A1 (en) * 1998-02-18 1999-08-26 The Research Foundation Of State University Of New York Galactosaminoglycan-based extracellular matrix for wound healing
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
DE19841698A1 (de) * 1998-09-11 2000-03-16 Curative Technologies Gmbh Wachstumsfaktor-enthaltende Zusammensetzung zur Heilung von Gewebeschäden
DE19851334C2 (de) * 1998-11-06 2000-09-28 Aventis Behring Gmbh Flexible Wundauflage auf Fibrinbasis und Verfahren zu ihrer Herstellung
US7276235B2 (en) * 1998-11-18 2007-10-02 Zlb Behring Gmbh Tissue glue with improved antiadhesive properties
JP4889861B2 (ja) 1998-11-18 2012-03-07 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 組織接着剤のための安定化されたタンパク質調製物
US7572769B2 (en) 1998-12-23 2009-08-11 Csl Behring Gmbh Fibrin adhesive granulate and method for its preparation
AU754458B2 (en) * 1998-12-23 2002-11-14 Csl Behring Gmbh Fibrin-based glue granulate and corresponding production method
US6946140B1 (en) 1999-02-09 2005-09-20 The Research Foundation Of State University Of New York Methods and compositions for enhancing fibroblast migration
WO2000047148A1 (en) * 1999-02-09 2000-08-17 The Research Foundation Of State University Of New York Methods and compositions for enhancing fibroblast migration
WO2000047621A1 (en) * 1999-02-12 2000-08-17 Baxter Aktiengesellschaft A method for producing a preparation based on fibrinogen and fibronectin as well as protein compositions obtainable according to this method
JP4771594B2 (ja) * 1999-02-12 2011-09-14 バクスター アクチェンゲゼルシャフト フィブリノーゲンおよびフィブロネクチンをベースとする製剤を生成するための方法ならびにこの方法により入手可能なタンパク質組成物
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
US6183498B1 (en) 1999-09-20 2001-02-06 Devore Dale P. Methods and products for sealing a fluid leak in a tissue
US20030095993A1 (en) * 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
AU778318B2 (en) * 2000-02-03 2004-11-25 Tissuemed Limited Device for the closure of a surgical puncture
US6627785B1 (en) * 2000-02-29 2003-09-30 Virginia Commwealth University Wound dressings with protease-lowering activity
US20070009586A1 (en) * 2000-02-29 2007-01-11 Cohen Kelman I Wound dressings containing complexes of transition metals and alginate for elastase sequestering
US6309454B1 (en) 2000-05-12 2001-10-30 Johnson & Johnson Medical Limited Freeze-dried composite materials and processes for the production thereof
US6447799B1 (en) * 2000-07-24 2002-09-10 Joseph M. Ullman Thromboplastic system
DK1328300T3 (da) * 2000-10-23 2005-03-21 Tissuemed Ltd Selvklæbende hydratiserbar matrix til topisk terapeutisk anvendelse
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US7098315B2 (en) 2001-01-25 2006-08-29 Nycomed Pharma As Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge
US6733774B2 (en) 2001-01-25 2004-05-11 Nycomed Pharma As Carrier with solid fibrinogen and solid thrombin
US20020164322A1 (en) * 2001-01-25 2002-11-07 Alfred Schaufler Suspension comprising fibrinogen, thrombin and alcohol, a method for preparing such a suspension, a method for coating a carrier with such a suspension, a method of drying a coating of a carrier, and a coated collagen sponge
EP1359947A2 (de) * 2001-01-25 2003-11-12 Nycomed Pharma AS Suspension mit fibrinogen, thrombin und alkohol und verfahren zum beschichten eines trägers damit
US7052713B2 (en) 2001-02-13 2006-05-30 Nycomed Pharma As Carrier with solid fibrinogen and solid thrombin
US6656488B2 (en) * 2001-04-11 2003-12-02 Ethicon Endo-Surgery, Inc. Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
DE10135507A1 (de) * 2001-07-20 2003-02-06 Henkel Kgaa Blutstillendes Hautpflaster
WO2004010913A1 (en) * 2001-07-25 2004-02-05 Us Army Medical Research & Materiel Command Fibrinogen bandages and methods
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US7374678B2 (en) 2002-05-24 2008-05-20 Biomet Biologics, Inc. Apparatus and method for separating and concentrating fluids containing multiple components
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
DE10392686T5 (de) 2002-05-24 2005-07-07 Biomet Mfg. Corp., Warsaw Vorrichtung und Verfahren zum Trennen und Konzentrieren von Flüssigkeiten, welche mehrere Komponenten enthalten
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
JP4777650B2 (ja) * 2002-09-10 2011-09-21 アメリカン ナショナル レッド クロス 止血用包帯
EP1588722A4 (de) * 2003-01-20 2011-03-02 Chemo Sero Therapeut Res Inst Hämostatische materialien
AU2004226578A1 (en) * 2003-04-04 2004-10-14 Tissuemed Limited Tissue-adhesive formulations
US20040243044A1 (en) * 2003-06-02 2004-12-02 Penegor Stephen A. Hemostatic wound dressing
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
ATE515245T1 (de) 2003-12-11 2011-07-15 Isto Technologies Inc Teilchenförmiges knorpelsystem
CA2567297A1 (en) * 2004-05-21 2005-12-01 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Tissue sealant
EP1793873B1 (de) * 2004-08-03 2013-08-07 Tissuemed Limited Gewebekleber
WO2006021584A2 (en) * 2004-08-27 2006-03-02 Novo Nordisk Health Care Ag Purification of factor xiii polypeptides from biological materials
JPWO2006033433A1 (ja) * 2004-09-24 2008-05-15 財団法人化学及血清療法研究所 創傷治癒剤
US20060258995A1 (en) * 2004-10-20 2006-11-16 Pendharkar Sanyog M Method for making a reinforced absorbable multilayered fabric for use in medical devices
ES2391641T3 (es) 2004-10-20 2012-11-28 Ethicon, Inc. Apósito hemostático multicapa absorbible reforzado para heridas y su procedimiento de fabricación
US9358318B2 (en) 2004-10-20 2016-06-07 Ethicon, Inc. Method of making a reinforced absorbable multilayered hemostatic wound dressing
ATE540974T1 (de) 2004-11-23 2012-01-15 Zymogenetics Inc Reinigung des rekombinanten menschlichen faktors xiii
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
WO2006086199A1 (en) 2005-02-07 2006-08-17 Hanuman Llc Platelet rich plasma concentrate apparatus and method
EP1848474B1 (de) 2005-02-07 2013-06-12 Hanuman LLC Vorrichtung und verfahren mit blutplättchenreichem plasmakonzentrat
AU2006282754A1 (en) 2005-08-26 2007-03-01 Zimmer, Inc. Implants and methods for repair, replacement and treatment of joint disease
US20070083972A1 (en) * 2005-09-26 2007-04-19 Peter Francis Rebel office shirt
US8277837B2 (en) 2006-01-11 2012-10-02 Entegrion, Inc. Hemostatic textile
CA2640629A1 (en) 2006-02-03 2007-08-09 Tissuemed Limited Tissue-adhesive materials
US20090018575A1 (en) * 2006-03-01 2009-01-15 Tissuemed Limited Tissue-adhesive formulations
US20070224251A1 (en) * 2006-03-22 2007-09-27 Masao Tanihara Hemostatic material
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
CN101454030B (zh) * 2006-05-31 2013-06-26 巴克斯特国际公司 用于脊柱外科手术中定向细胞向内生长和控制组织再生的方法
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
US20160106883A1 (en) * 2014-10-15 2016-04-21 Stb, Ltd. Processes For Mixing Fibrinogen and Thrombin Under Conditions That Minimize Fibrin Formation While Preserving Fibrin-forming Ability, Compositions Produced by These Processes, and the Use Thereof
WO2008019128A2 (en) * 2006-08-04 2008-02-14 Stb Lifesaving Technologies, Inc. Solid dressing for treating wounded tissue
US20080138387A1 (en) * 2006-12-07 2008-06-12 Machiraju Venkat R Hemostatic sponge and article
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
JP5479319B2 (ja) 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー ブイ式懸濁液分画システム
CA2684040C (en) 2007-04-12 2016-12-06 Isto Technologies, Inc. Method of forming an implant using a mold that mimics the shape of the tissue defect site and implant formed therefrom
WO2008128546A1 (en) * 2007-04-20 2008-10-30 Coloplast A/S Multi component non-woven
WO2009020612A1 (en) * 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Methods and dressing for sealing internal injuries
GB0715514D0 (en) * 2007-08-10 2007-09-19 Tissuemed Ltd Coated medical devices
DE102007045066A1 (de) 2007-09-20 2009-04-02 Mike Ehrlich Material zur Blutstillung enthaltend synthetische Peptide oder Polysaccharide
JP2011500237A (ja) 2007-10-30 2011-01-06 バクスター・インターナショナル・インコーポレイテッド 内臓または体腔壁の欠陥を治療するための再生性の生体機能性コラーゲン生物基質の使用
EP2567692B1 (de) 2008-02-27 2016-04-06 Biomet Biologics, LLC Verwendung einer Vorrichtung zur Erzeugung Interleukin-1-rezeptorantagonistreicher Lösungen
WO2009109194A2 (en) 2008-02-29 2009-09-11 Ferrosan A/S Device for promotion of hemostasis and/or wound healing
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
CA2721335A1 (en) 2008-04-16 2009-10-22 Ryoichi Kawamura Process for preparing bioabsorbable sheet preparation holding thrombin
US8012077B2 (en) 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
PT2442835E (pt) * 2009-06-16 2015-03-23 Baxter Healthcare Sa Esponja hemostática
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US9271925B2 (en) 2013-03-11 2016-03-01 Bioinspire Technologies, Inc. Multi-layer biodegradable device having adjustable drug release profile
WO2011035020A1 (en) 2009-09-18 2011-03-24 Bioinspire Technologies, Inc. Free-standing biodegradable patch
JP2013514093A (ja) * 2009-12-16 2013-04-25 バクスター・インターナショナル・インコーポレイテッド 止血スポンジ
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
CN103037845B (zh) 2010-06-01 2015-11-25 巴克斯特国际公司 用于制备干燥、稳定的止血组合物的方法
US9084728B2 (en) 2010-06-01 2015-07-21 Baxter International Inc. Process for making dry and stable hemostatic compositions
JP6289096B2 (ja) 2010-06-01 2018-03-07 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 乾燥した安定な止血組成物を作製するためのプロセス
US9427360B2 (en) 2010-11-04 2016-08-30 W. Jerry Mezger Hemostatic fabric
UY34096A (es) 2011-05-24 2018-06-29 Nycomed Pharma As Soporte de colageno enrollado
RU2013155713A (ru) 2011-07-06 2015-08-20 Профибрикс Бв Составы для лечения ран
US9561300B2 (en) 2011-09-26 2017-02-07 Yes, Inc. Hemostatic compositions and dressings for bleeding
US20130090291A1 (en) 2011-10-11 2013-04-11 Baxter Healthcare S.A. Hemostatic compositions
AU2012318257B2 (en) 2011-10-11 2015-10-01 Baxter Healthcare S.A. Hemostatic compositions
WO2013056116A1 (en) * 2011-10-12 2013-04-18 The Trustees Of Columbia University In The City Of New York Hemostatic dressing for arterial bleeding
US20130108671A1 (en) 2011-10-27 2013-05-02 Baxter Healthcare S.A. Hemostatic compositions
JP6241624B2 (ja) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス 止血ペーストを収容する加圧容器
WO2013172472A1 (ja) 2012-05-14 2013-11-21 帝人株式会社 シート成形体および止血材
WO2013174874A1 (en) 2012-05-24 2013-11-28 Takeda Nycomed As Apparatus and process for providing a coiled collagen carrier
PL2854737T3 (pl) 2012-05-24 2017-04-28 Takeda As Opakowanie
JP6394916B2 (ja) 2012-06-12 2018-09-26 フェロサン メディカル デバイシーズ エイ／エス 乾燥止血組成物
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
US10765774B2 (en) * 2013-07-09 2020-09-08 Ethicon, Inc. Hemostatic pad assembly kit and method
CA2928963C (en) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US10406255B2 (en) 2014-05-28 2019-09-10 Highland Industries, Inc. Hemostatic textile
JP6726852B2 (ja) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス 止血および創傷治癒に使用するための乾燥組成物
JP6747650B2 (ja) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス 第１の物質と第２の物質を保持し混合するためのシリンジ
JP6810052B2 (ja) 2015-03-27 2021-01-06 スリーエム イノベイティブ プロパティズ カンパニー フィブリン組成物、方法及び創傷物品
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
US11827754B2 (en) 2016-10-05 2023-11-28 3M Innovative Properties Company Fibrin composition comprising carrier material, method and wound articles
EP3522941A4 (de) 2016-10-05 2020-06-17 3M Innovative Properties Company Fibrinogenzusammensetzung, verfahren und wundartikel
JP7108541B2 (ja) 2016-10-18 2022-07-28 ロート製薬株式会社 疾患治療剤調製用キット、疾患治療剤及び疾患治療剤の調製方法
JP7395113B2 (ja) 2018-05-09 2023-12-11 フェロサン メディカル デバイシーズ エイ／エス 止血組成物を調製する方法
CN113195225A (zh) 2018-12-14 2021-07-30 Bmg株式会社 2反应剂型的片状组织粘接加强材料
US20220023491A1 (en) * 2020-07-21 2022-01-27 Ethicon, Inc. Hemostatic Composite Aggregate Materials Having Surface Enriched with Hemostatis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB704517A (en) * 1951-08-07 1954-02-24 Schering Ag Improvements relating to media for stopping the flow of blood
FR6652M (de) * 1966-12-28 1969-01-27
US4265233A (en) * 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
AT359652B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes

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GR75042B (de) 1984-07-12
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HU183823B (en) 1984-06-28
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ATE15143T1 (de) 1985-09-15
EP0059265B1 (de) 1985-08-28
CA1181689A (en) 1985-01-29
DE3105624A1 (de) 1982-09-02
JPS6134830B2 (de) 1986-08-09
DE10199040I2 (de) 2003-01-09
US4453939A (en) 1984-06-12
JPS57153645A (en) 1982-09-22
EP0059265A1 (de) 1982-09-08

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