DE3374062D1 - Anti-inflammatory products derived from methylenediphosphonic acid, and process for their preparation - Google Patents

Anti-inflammatory products derived from methylenediphosphonic acid, and process for their preparation

Info

Publication number
DE3374062D1
DE3374062D1 DE8383401520T DE3374062T DE3374062D1 DE 3374062 D1 DE3374062 D1 DE 3374062D1 DE 8383401520 T DE8383401520 T DE 8383401520T DE 3374062 T DE3374062 T DE 3374062T DE 3374062 D1 DE3374062 D1 DE 3374062D1
Authority
DE
Germany
Prior art keywords
preparation
products derived
methylenediphosphonic acid
inflammatory products
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383401520T
Other languages
English (en)
Inventor
Jean-Claude Breliere
Xavier Emonds-Alt
George Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of DE3374062D1 publication Critical patent/DE3374062D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE8383401520T 1982-07-29 1983-07-25 Anti-inflammatory products derived from methylenediphosphonic acid, and process for their preparation Expired DE3374062D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8213250A FR2531088B1 (fr) 1982-07-29 1982-07-29 Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation

Publications (1)

Publication Number Publication Date
DE3374062D1 true DE3374062D1 (en) 1987-11-19

Family

ID=9276447

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383401520T Expired DE3374062D1 (en) 1982-07-29 1983-07-25 Anti-inflammatory products derived from methylenediphosphonic acid, and process for their preparation

Country Status (35)

Country Link
US (2) US4746654A (de)
EP (1) EP0100718B1 (de)
JP (1) JPS5942395A (de)
KR (1) KR910000726B1 (de)
AR (2) AR242393A1 (de)
AT (1) ATE30235T1 (de)
AU (1) AU566880B2 (de)
CA (1) CA1267650A (de)
CS (1) CS252463B2 (de)
CZ (1) CZ419191A3 (de)
DD (1) DD213670A5 (de)
DE (1) DE3374062D1 (de)
DK (1) DK170342B1 (de)
DZ (1) DZ562A1 (de)
EG (1) EG15968A (de)
ES (1) ES8403923A1 (de)
FI (1) FI75830C (de)
FR (1) FR2531088B1 (de)
GR (1) GR79597B (de)
HU (1) HU190454B (de)
IE (1) IE56343B1 (de)
IL (1) IL69347A (de)
LU (1) LU88723I2 (de)
MA (1) MA19858A1 (de)
NL (1) NL960007I2 (de)
NO (2) NO164712C (de)
NZ (1) NZ205061A (de)
OA (1) OA07507A (de)
PH (1) PH22082A (de)
PL (2) PL141316B1 (de)
PT (1) PT77122B (de)
SG (1) SG18588G (de)
SU (2) SU1333240A3 (de)
YU (1) YU45143B (de)
ZA (1) ZA835578B (de)

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* Cited by examiner, † Cited by third party
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PH22082A (en) 1988-05-20
OA07507A (fr) 1985-03-31
YU45143B (en) 1992-03-10
ES524495A0 (es) 1984-04-16
SU1367859A3 (ru) 1988-01-15
FI75830C (fi) 1988-08-08
JPH0429676B2 (de) 1992-05-19
FR2531088A1 (fr) 1984-02-03
IE56343B1 (en) 1991-07-03
IL69347A (en) 1987-02-27
HU190454B (en) 1986-09-29
DD213670A5 (de) 1984-09-19
PL141316B1 (en) 1987-07-31
FI832758A0 (fi) 1983-07-29
KR840005459A (ko) 1984-11-12
NL960007I1 (nl) 1996-09-02
NL960007I2 (nl) 1997-03-03
US4746654A (en) 1988-05-24
US4876248A (en) 1989-10-24
KR910000726B1 (ko) 1991-01-31
CS252463B2 (en) 1987-09-17
CA1267650A (en) 1990-04-10
DZ562A1 (fr) 2004-09-13
CS568883A2 (en) 1987-01-15
GR79597B (de) 1984-10-31
AR242394A1 (es) 1993-03-31
JPS5942395A (ja) 1984-03-08
EP0100718B1 (de) 1987-10-14
PT77122B (fr) 1986-01-24
NO1998011I1 (no) 1998-03-06
NZ205061A (en) 1987-08-31
LU88723I2 (fr) 1996-08-23
SU1333240A3 (ru) 1987-08-23
FI75830B (fi) 1988-04-29
DK336783D0 (da) 1983-07-22
ZA835578B (en) 1984-04-25
PL243229A1 (en) 1984-07-16
AU1732483A (en) 1984-02-02
DK336783A (da) 1984-01-30
AR242393A1 (es) 1993-03-31
SG18588G (en) 1988-09-30
EP0100718A1 (de) 1984-02-15
MA19858A1 (fr) 1984-04-01
DK170342B1 (da) 1995-08-07
PT77122A (fr) 1983-08-01
AU566880B2 (en) 1987-11-05
ATE30235T1 (de) 1987-10-15
FR2531088B1 (fr) 1987-08-28
ES8403923A1 (es) 1984-04-16
YU160083A (en) 1986-08-31
NO164712B (no) 1990-07-30
PL142022B1 (en) 1987-09-30
CZ419191A3 (en) 1993-10-13
IE831716L (en) 1984-01-29
IL69347A0 (en) 1983-11-30
NO832701L (no) 1984-01-30
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EG15968A (en) 1989-01-30
FI832758A (fi) 1984-01-30

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