DE3379268D1 - 1'-(3-(1,2-benzisoxazol-3-yl)propyl)spiro-(benzofuran-2-(3h),3' or 4'-piperidine or 3'-pyrrolidines), a process for their preparation and their use as medicaments - Google Patents

1'-(3-(1,2-benzisoxazol-3-yl)propyl)spiro-(benzofuran-2-(3h),3' or 4'-piperidine or 3'-pyrrolidines), a process for their preparation and their use as medicaments

Info

Publication number
DE3379268D1
DE3379268D1 DE8383109520T DE3379268T DE3379268D1 DE 3379268 D1 DE3379268 D1 DE 3379268D1 DE 8383109520 T DE8383109520 T DE 8383109520T DE 3379268 T DE3379268 T DE 3379268T DE 3379268 D1 DE3379268 D1 DE 3379268D1
Authority
DE
Germany
Prior art keywords
benzisoxazol
pyrrolidines
benzofuran
spiro
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383109520T
Other languages
English (en)
Inventor
Larry Davis
Frank A Pierrat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3379268D1 publication Critical patent/DE3379268D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
DE8383109520T 1982-09-29 1983-09-24 1'-(3-(1,2-benzisoxazol-3-yl)propyl)spiro-(benzofuran-2-(3h),3' or 4'-piperidine or 3'-pyrrolidines), a process for their preparation and their use as medicaments Expired DE3379268D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/424,379 US4420485A (en) 1982-09-29 1982-09-29 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]

Publications (1)

Publication Number Publication Date
DE3379268D1 true DE3379268D1 (en) 1989-04-06

Family

ID=23682416

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383109520T Expired DE3379268D1 (en) 1982-09-29 1983-09-24 1'-(3-(1,2-benzisoxazol-3-yl)propyl)spiro-(benzofuran-2-(3h),3' or 4'-piperidine or 3'-pyrrolidines), a process for their preparation and their use as medicaments

Country Status (4)

Country Link
US (1) US4420485A (de)
EP (1) EP0104632B1 (de)
JP (1) JPS5982388A (de)
DE (1) DE3379268D1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788201A (en) * 1987-01-22 1988-11-29 Hoechst-Roussel Pharmaceuticals Inc. 3-methylenespiro (benzofuranpiperidines)
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
DK0681571T3 (da) * 1993-01-28 1998-11-23 Merck & Co Inc Spiro-substituerede azacykliske forbindelser som tachykininreceptorantagonister
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
US5434158A (en) * 1994-04-26 1995-07-18 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin-3 antagonists
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
US6110935A (en) 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
US6013652A (en) * 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO122593B (de) * 1964-11-26 1971-07-19 Shionogi & Co
US3732306A (en) * 1970-07-02 1973-05-08 Stauffer Chemical Co Certain oxime esters and their use as acaricides and in controlling fungi and bacteria
US3960951A (en) * 1972-07-27 1976-06-01 Stauffer Chemical Company Certain oxime esters
JPS4970963A (de) * 1972-11-09 1974-07-09
US4007227A (en) * 1973-02-08 1977-02-08 Stauffer Chemical Company Certain oxime compositions and their use in controlling fungi
GB1488003A (en) * 1973-10-23 1977-10-05 Lilly Industries Ltd 1,2-benzisoxazole derivatives processes for their preparation and their use as pharmaceuticals
JPS5136666A (en) * 1974-09-25 1976-03-27 Hitachi Ltd Konendobutsushitsu no yokogatarenzokukonwaki
FI60390C (fi) * 1975-03-05 1982-01-11 Sumitomo Chemical Co Foerfarande foer framstaellning av neuroleptiska butyrofenoner
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
US4128580A (en) * 1976-01-30 1978-12-05 Stauffer Chemical Company Process for the production of 1,3-dichloroacetone oxime and its acetate derivative
JPS6033114B2 (ja) * 1976-12-16 1985-08-01 大日本製薬株式会社 １，２−ベンズイソキサゾ−ル誘導体
US4166119A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4166120A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4192896A (en) * 1979-03-23 1980-03-11 Leach Byron E Method of using dialkylphenols in the treatment of mycoplasma diseases
JPS6043064B2 (ja) * 1979-11-28 1985-09-26 ウェルファイド株式会社 新規イソオキサゾ−ル誘導体
FI821415L (fi) * 1981-04-27 1982-10-28 Hoechst Roussel Pharma 1-/3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl/-4-hydroxi-4-fenylpiperidiner, foerfarande och mellanprodukter foer deras framstaellning och deras anvaendning som laekemedel

Also Published As

Publication number Publication date
EP0104632A3 (en) 1985-10-02
EP0104632A2 (de) 1984-04-04
EP0104632B1 (de) 1989-03-01
JPS5982388A (ja) 1984-05-12
US4420485A (en) 1983-12-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee