DE3440288C2 - - Google Patents

Info

Publication number
DE3440288C2
DE3440288C2 DE3440288A DE3440288A DE3440288C2 DE 3440288 C2 DE3440288 C2 DE 3440288C2 DE 3440288 A DE3440288 A DE 3440288A DE 3440288 A DE3440288 A DE 3440288A DE 3440288 C2 DE3440288 C2 DE 3440288C2
Authority
DE
Germany
Prior art keywords
ibuprofen
preparation
hydro
colloid
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3440288A
Other languages
English (en)
Other versions
DE3440288A1 (de
Inventor
Gerhard Dr.-Ing. Gergely
Irmgard Gergely
Thomas Dr. Wien At Gergely
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19843440288 priority Critical patent/DE3440288A1/de
Priority to EG67485A priority patent/EG19056A/xx
Priority to ZA858306A priority patent/ZA858306B/xx
Priority to AT85113806T priority patent/ATE52690T1/de
Priority to DK499185A priority patent/DK499185A/da
Priority to EP85113806A priority patent/EP0181564B1/de
Priority to DE8585113806T priority patent/DE3577655D1/de
Priority to HU854175A priority patent/HU195617B/hu
Priority to IL76890A priority patent/IL76890A/xx
Priority to NZ214018A priority patent/NZ214018A/xx
Priority to JP60243015A priority patent/JPS61115023A/ja
Priority to FI854303A priority patent/FI854303A/fi
Priority to HU86424A priority patent/HU201868B/hu
Priority to DE8585905803T priority patent/DE3575376D1/de
Priority to JP60505211A priority patent/JPH0753662B2/ja
Priority to EP85905803A priority patent/EP0232277B1/de
Priority to PCT/EP1985/000585 priority patent/WO1986002834A1/de
Priority to AT85905803T priority patent/ATE49501T1/de
Priority to AU51990/86A priority patent/AU584154B2/en
Priority to US06/794,636 priority patent/US4762702A/en
Priority to GR852650A priority patent/GR852650B/el
Priority to CA000494561A priority patent/CA1254143A/en
Priority to ES548517A priority patent/ES8701492A1/es
Priority to AU49318/85A priority patent/AU576399B2/en
Priority to DD85282437A priority patent/DD238529A5/de
Priority to NO854391A priority patent/NO854391L/no
Priority to PT81425A priority patent/PT81425B/pt
Publication of DE3440288A1 publication Critical patent/DE3440288A1/de
Priority to US06/887,808 priority patent/US4888177A/en
Application granted granted Critical
Publication of DE3440288C2 publication Critical patent/DE3440288C2/de
Priority to FI871951A priority patent/FI91936C/fi
Priority to SU874202610A priority patent/RU1787029C/ru
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
DE19843440288 1984-11-05 1984-11-05 Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung Granted DE3440288A1 (de)

Priority Applications (30)

Application Number Priority Date Filing Date Title
DE19843440288 DE3440288A1 (de) 1984-11-05 1984-11-05 Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung
EG67485A EG19056A (en) 1984-11-05 1985-10-23 Pharmaceutical preparation containing ibuprofen and a methode of its production
ZA858306A ZA858306B (en) 1984-11-05 1985-10-29 Pharmaceutical preparation with a content of ibuprofen,and process for its preparation
DK499185A DK499185A (da) 1984-11-05 1985-10-30 Farmaceutisk praeparat med et indhold af ibuprofen samt fremgangsmaade til fremstilling heraf
AT85113806T ATE52690T1 (de) 1984-11-05 1985-10-30 Pharmazeutische zubereitung mit einem gehalt an ibuprofen, sowie verfahren zu ihrer herstellung.
EP85113806A EP0181564B1 (de) 1984-11-05 1985-10-30 Pharmazeutische Zubereitung mit einem Gehalt an Ibuprofen, sowie Verfahren zu ihrer Herstellung
DE8585113806T DE3577655D1 (de) 1984-11-05 1985-10-30 Pharmazeutische zubereitung mit einem gehalt an ibuprofen, sowie verfahren zu ihrer herstellung.
HU854175A HU195617B (en) 1984-11-05 1985-10-31 Process for producing pharmaceutical compositions containing 2-/4-isobutyl-phenyl6-propionic acid
IL76890A IL76890A (en) 1984-11-05 1985-10-31 Pharmaceutical preparation with a content of ibuprofen and process for its preparation
NZ214018A NZ214018A (en) 1984-11-05 1985-10-31 Pharmaceutical compositions containing ibuprofen
JP60243015A JPS61115023A (ja) 1984-11-05 1985-10-31 イブプロフェンを含有する薬剤学的製剤およびその製造法
FI854303A FI854303A (fi) 1984-11-05 1985-11-01 Farmaceutisk beredning innehaollande ibuprofen och foerfarande foer framstaellning av densamma.
EP85905803A EP0232277B1 (de) 1984-11-05 1985-11-02 Pharmazeutische zubereitungen in form von instantgranulaten oder -tabletten, sowie verfahren zu deren herstellung
JP60505211A JPH0753662B2 (ja) 1984-11-05 1985-11-02 薬剤学的製剤及びその製造方法
HU86424A HU201868B (en) 1984-11-05 1985-11-02 Process for the production of pharmaceutical products in the form of instant granulates, teblets, foam powder or foam tablets
PCT/EP1985/000585 WO1986002834A1 (fr) 1984-11-05 1985-11-02 Preparations pharmaceutiques sous forme de granules ou pilules instantanes, et procede de fabrication
AT85905803T ATE49501T1 (de) 1984-11-05 1985-11-02 Pharmazeutische zubereitungen in form von instantgranulaten oder -tabletten, sowie verfahren zu deren herstellung.
AU51990/86A AU584154B2 (en) 1984-11-05 1985-11-02 Pharmaceutical preparations in the form of instant granules or tablets, and process for their manufacture
DE8585905803T DE3575376D1 (de) 1984-11-05 1985-11-02 Pharmazeutische zubereitungen in form von instantgranulaten oder -tabletten, sowie verfahren zu deren herstellung.
ES548517A ES8701492A1 (es) 1984-11-05 1985-11-04 Preparado farmaceutico
GR852650A GR852650B (de) 1984-11-05 1985-11-04
CA000494561A CA1254143A (en) 1984-11-05 1985-11-04 Pharmaceutical preparation with a content of ibuprofen, and process for its preparation
US06/794,636 US4762702A (en) 1984-11-05 1985-11-04 Pharmaceutical preparation containing ibuprofen and a process for its preparation
AU49318/85A AU576399B2 (en) 1984-11-05 1985-11-04 Ibuprofen particles enveloped by a coating of a pseudo- colloid and pumaric acid
DD85282437A DD238529A5 (de) 1984-11-05 1985-11-04 Verfahren zur herstellung einer pharmazeutischen zubereitung mit einem gehalt an ibuprofen
NO854391A NO854391L (no) 1984-11-05 1985-11-04 Farmasoeytisk matrise for ibuprofen.
PT81425A PT81425B (pt) 1984-11-05 1985-11-04 Processo para a preparacao de composicoes farmaceuticas contendo acido alfa-metil-4-(2-metilpropil)- benzeno-acetico
US06/887,808 US4888177A (en) 1984-11-05 1986-07-02 Pharamaceutical preparations in the form of instant granules or tablets and process for their manufacture
SU874202610A RU1787029C (ru) 1984-11-05 1987-05-04 Способ получени гранул та лекарственного средства
FI871951A FI91936C (fi) 1984-11-05 1987-05-04 Menetelmä kiinteän lääkevalmisteen valmistamiseksi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843440288 DE3440288A1 (de) 1984-11-05 1984-11-05 Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
DE3440288A1 DE3440288A1 (de) 1986-05-07
DE3440288C2 true DE3440288C2 (de) 1987-03-12

Family

ID=6249478

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19843440288 Granted DE3440288A1 (de) 1984-11-05 1984-11-05 Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung
DE8585113806T Expired - Lifetime DE3577655D1 (de) 1984-11-05 1985-10-30 Pharmazeutische zubereitung mit einem gehalt an ibuprofen, sowie verfahren zu ihrer herstellung.
DE8585905803T Expired - Lifetime DE3575376D1 (de) 1984-11-05 1985-11-02 Pharmazeutische zubereitungen in form von instantgranulaten oder -tabletten, sowie verfahren zu deren herstellung.

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE8585113806T Expired - Lifetime DE3577655D1 (de) 1984-11-05 1985-10-30 Pharmazeutische zubereitung mit einem gehalt an ibuprofen, sowie verfahren zu ihrer herstellung.
DE8585905803T Expired - Lifetime DE3575376D1 (de) 1984-11-05 1985-11-02 Pharmazeutische zubereitungen in form von instantgranulaten oder -tabletten, sowie verfahren zu deren herstellung.

Country Status (21)

Country Link
US (2) US4762702A (de)
EP (2) EP0181564B1 (de)
JP (2) JPS61115023A (de)
AT (1) ATE52690T1 (de)
AU (2) AU584154B2 (de)
CA (1) CA1254143A (de)
DD (1) DD238529A5 (de)
DE (3) DE3440288A1 (de)
DK (1) DK499185A (de)
EG (1) EG19056A (de)
ES (1) ES8701492A1 (de)
FI (2) FI854303A (de)
GR (1) GR852650B (de)
HU (2) HU195617B (de)
IL (1) IL76890A (de)
NO (1) NO854391L (de)
NZ (1) NZ214018A (de)
PT (1) PT81425B (de)
RU (1) RU1787029C (de)
WO (1) WO1986002834A1 (de)
ZA (1) ZA858306B (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3440288A1 (de) * 1984-11-05 1986-05-07 Gergely, Gerhard, Dr.-Ing., Wien Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung
GB8601204D0 (en) * 1986-01-18 1986-02-19 Boots Co Plc Therapeutic agents
IT1191674B (it) * 1986-03-07 1988-03-23 Eurand Spa Formulazioni per la preparazione di farmaci a rilascio prolungato adatte alla somministrazione per via orale
GB8702411D0 (en) * 1987-02-03 1987-03-11 Zyma Sa Swellable pellets
US5288500A (en) * 1987-03-13 1994-02-22 Benzon Pharma A/S Oral composition containing particles comprising an active substance
DK130287D0 (da) * 1987-03-13 1987-03-13 Benzon As Alfred Oralt praeparat
US4980375A (en) * 1987-07-10 1990-12-25 Sterling Drug Inc. Onset-hastened/enhanced antipyretic response
US4994276A (en) * 1988-09-19 1991-02-19 Edward Mendell Co., Inc. Directly compressible sustained release excipient
US5466469A (en) * 1988-06-28 1995-11-14 Cibus Pharmaceutical, Inc. Granular drug delivery system
US5215752A (en) * 1988-03-17 1993-06-01 Vectorpharma International S.P.A. Pharmaceutical tablets and capsule granulates of scleroglucan and active substance
US5180587A (en) * 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
HU208610B (en) * 1988-06-28 1993-12-28 Du Pont Pesticidal and plant growth regulating composition in tablet form
US5128143A (en) * 1988-09-19 1992-07-07 Edward Mendell Co., Inc. Sustained release excipient and tablet formulation
US5169639A (en) * 1988-09-19 1992-12-08 Edward Mendell Co., Inc. Controlled release verapamil tablets
US5135757A (en) * 1988-09-19 1992-08-04 Edward Mendell Co., Inc. Compressible sustained release solid dosage forms
WO1991003241A1 (de) * 1989-09-07 1991-03-21 Gerhard Gergely Magensäure bindende, pharmazeutische zubereitung
US5064656A (en) * 1989-11-14 1991-11-12 Dr. Gergely & Co. Uncoated pharmaceutical reaction tablet
US5814337A (en) * 1992-10-07 1998-09-29 Beecham Group Plc Pharmaceutical formulation
GB9007945D0 (en) * 1990-04-07 1990-06-06 Beecham Group Plc Pharmaceutical formulation
IT1246383B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per il mascheramento del sapore di farmaci
GB9009473D0 (en) 1990-04-27 1990-06-20 Beecham Group Plc Pharmaceutical formulation
US5670170A (en) * 1990-04-27 1997-09-23 Beecham Group P.L.C. Pharamaceutical formulation
IT1246350B (it) * 1990-07-11 1994-11-17 Eurand Int Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili
DE4027927A1 (de) * 1990-09-04 1992-03-05 Bayer Ag Brausekomponente und verfahren zu ihrer herstellung
US5252337A (en) * 1991-06-25 1993-10-12 Eurand America, Inc. Controlled release calcium channel blocker microcapsules
EP0525388B1 (de) * 1991-07-01 1995-09-20 Gerhard Dr. Gergely Lutsch- oder Kautablette
US5605930A (en) * 1991-10-21 1997-02-25 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for treating and preventing pathologies including cancer
MX9300110A (es) * 1992-01-13 1994-07-29 Gerhard Gergely Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion.
US5472711A (en) * 1992-07-30 1995-12-05 Edward Mendell Co., Inc. Agglomerated hydrophilic complexes with multi-phasic release characteristics
US5503846A (en) * 1993-03-17 1996-04-02 Cima Labs, Inc. Base coated acid particles and effervescent formulation incorporating same
ATE140621T1 (de) * 1993-04-15 1996-08-15 Gergely Gerhard Brausesystem mit einem alkali- und/oder metallempfindlichen, pharmazeutischen wirkstoff, und verfahren zur herstellung
US5866162A (en) * 1993-08-10 1999-02-02 Smithkline Beecham P.L.C. Pharmaceutical composition containing a drug/β-cyclodextrin complex in combination with an acid-base couple
GB9316580D0 (en) * 1993-08-10 1993-09-29 Smithkline Beecham Plc Pharmaceutical composition
EP0642784B1 (de) * 1993-09-07 1999-05-19 Gerhard Dr. Gergely Brausemischung mit Alkalisalzen oder Lysinaten saurer, unlöslicher oder schwer löslicher Wirkstoffe
TW442287B (en) * 1995-06-13 2001-06-23 American Home Produits Corp Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac)
AU2068797A (en) * 1996-01-29 1997-08-20 Edward Mendell Co. Inc. Sustained release excipient
DE19606151C2 (de) * 1996-02-20 1999-05-12 Losan Pharma Gmbh Ibuprofen-Brausezubereitung sowie Verfahren zur Herstellung derselben
US6974595B1 (en) * 1996-05-17 2005-12-13 Proethic Pharmaceuticals, Inc. Pharmaceutical compositions based on Diclofenae
IN186245B (de) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
US5888523A (en) * 1997-09-22 1999-03-30 Biocontrol, Inc. Topical non-steroidal anti-inflammatory drug composition
NZ333474A (en) 1998-01-02 1999-06-29 Mcneil Ppc Inc A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
DE19814257A1 (de) * 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
EP1116485A3 (de) * 2000-01-10 2002-01-16 Gerhard Dr. Gergely Instant-Granulat und Verfahren zu seiner Herstellung
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
US20040033302A1 (en) * 2002-08-14 2004-02-19 Himanshu Shah Bland-tasting edible product
JP4501024B2 (ja) * 2002-11-14 2010-07-14 小林製薬株式会社 システイン類の苦味及び臭気が軽減された組成物
JP4501023B2 (ja) * 2002-11-14 2010-07-14 小林製薬株式会社 システイン類の苦味及び臭気が軽減された組成物
EP1582221A1 (de) * 2004-03-31 2005-10-05 Chiesi S.A. Orale Pharmazeutische zusammensetzung zur Geschmacksmaskierung
JP2007308479A (ja) 2006-04-20 2007-11-29 Shin Etsu Chem Co Ltd 固体分散体製剤
JP5389656B2 (ja) 2006-10-20 2014-01-15 マクニール−ピーピーシー・インコーポレーテツド アセトアミノフェン／イブプロフェンの組み合わせおよびこれらの使用方法
MX2009004439A (es) * 2006-10-25 2009-05-11 Mcneil Ppc Inc Composicion de ibuprofeno.
JP5663238B2 (ja) * 2009-08-31 2015-02-04 ライオン株式会社 内服固形製剤及びその製造方法
CN104640571A (zh) 2012-09-18 2015-05-20 麦克内尔-Ppc股份有限公司 包含低熔点丙酸衍生物颗粒的缓释口服剂型
EP2897584A1 (de) 2012-09-18 2015-07-29 McNeil-PPC, Inc. Niedrigschmelzende propionsäurederivatpartikel zur verwendung in oralen darreichungsformen
KR101340733B1 (ko) * 2012-12-31 2013-12-12 (주) 에프엔지리서치 신규한 마이크로그래뉼 제형

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE343477C (de) * 1920-06-13 1921-11-03 Schlesinger & Co Formmaschine mit einem auf- und abwaerts bewegbaren Tisch
GB970462A (en) * 1962-05-02 1964-09-23 Monsanto Co Free-flowing acid compositions
GB1178294A (en) * 1967-02-17 1970-01-21 Miles Lab Improvements in or relating to Tableting Lubricants.
FR2036890B1 (de) * 1969-04-15 1973-01-12 Orsymonde
US3780195A (en) * 1969-10-22 1973-12-18 Balchem Corp Encapsulation process
US3887700A (en) * 1969-11-28 1975-06-03 Aspro Nicholas Ltd Analgesic formulations
BE759520A (fr) * 1969-11-28 1971-04-30 Aspro Nicholas Ltd Compositions d'aspirine
US3764668A (en) * 1970-09-30 1973-10-09 Interx Research Corp Compositions of salts of salicylamide
US3676549A (en) * 1970-09-30 1972-07-11 Alza Corp Administration of alkali metal salts of salicylamide
US3962416A (en) * 1971-01-25 1976-06-08 Sol Katzen Preserved nutrients and products
GB1359614A (en) * 1971-04-06 1974-07-10 Dev Et De Rech Soc Fr De Method for the manufacture of effervescent tablets
DE2129570C3 (de) * 1971-06-15 1980-06-26 Hermes Suesstoff Ag, Zuerich (Schweiz) Mit Milch- oder Sojaeiweiß feuchtigkeitsstabilisierte Brausemischung
GB1561301A (en) * 1976-01-02 1980-02-20 Beecham Group Ltd Orally administrable pharmaceutical composition
JPS52139715A (en) * 1976-05-14 1977-11-21 Nippon Kayaku Co Ltd Coated granules of alkali polyacrylate
DE2750207A1 (de) * 1977-05-09 1978-11-16 Walton J Smith Gefriergetrocknete zusammensetzungen, insbesondere gefriergetrocknete pharmazeutische praeparate und verfahren zu deren herstellung
JPS551244A (en) * 1978-06-19 1980-01-08 Toyota Motor Corp Brake oil pressure controlling apparatus fof car
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
JPS5592341A (en) * 1979-01-05 1980-07-12 Kaken Pharmaceut Co Ltd Preparation of clathrate compound
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
US4309405A (en) * 1979-08-09 1982-01-05 American Home Products Corporation Sustained release pharmaceutical compositions
US4248857A (en) * 1979-08-09 1981-02-03 American Home Products Corporation Sustained release pharmaceutical compositions
JPS5634618A (en) * 1979-08-30 1981-04-06 Ota Seiyaku Kk Production of flurbiprofen preparation
JPS5646838A (en) * 1979-09-27 1981-04-28 Mitsubishi Yuka Yakuhin Kk 2- 2-fluoro-4-biphenylyl propionic acid-cyclodextrin clathrate compound
JPS5646839A (en) * 1979-09-27 1981-04-28 Mitsubishi Yuka Yakuhin Kk 4-allyloxy-3-chlorophenylacetic acid-cyclodextrin clathrate compound
JPS5646837A (en) * 1979-09-27 1981-04-28 Kowa Yakuhin Kogyo Kk Preparation of ibuprofen clathrate compound
AT371338B (de) * 1979-10-30 1983-06-27 Gergely Gerhard Reinigungstablette fuer zahnprothesen
US4344929A (en) * 1980-04-25 1982-08-17 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
AT368880B (de) * 1980-05-02 1982-11-25 Gergely Gerhard Verfahren zur herstellung eines zur weiterverarbeitung zu einer waesserigen suspension dienenden wasserunloeslichen trockeninstantpr[parates
JPS5785316A (en) * 1980-11-14 1982-05-28 Kanebo Ltd Preparation of easily absorbable nifedipine preparation
DE3127237A1 (de) * 1981-07-10 1983-01-20 Hoechst Ag, 6000 Frankfurt Magenvertraegliche arzneiformen von xanthinderivaten und verfahren zu ihrer herstellung
DE3143073A1 (de) * 1981-10-30 1983-05-11 Robert Bosch Gmbh, 7000 Stuttgart Einspritzpumpe mit einstellbarem spritzzeitpunkt
EP0093757A1 (de) * 1981-11-12 1983-11-16 Ulf SCHRÖDER Verfahren zur herstellung von magnetisch beeinflussbaren nanopartikeln für intravaskulare anwendung
JPS58198417A (ja) * 1982-05-15 1983-11-18 Ota Seiyaku Kk フルルビブロフエン錠の製造法
US4459280A (en) * 1982-07-23 1984-07-10 G. D. Searle & Co. Psyllium hydrophilic mucilloid composition
CA1209040A (fr) * 1982-12-21 1986-08-05 Jean Bru Procede de fabrication de granules et comprimes effervescents
GB8325627D0 (en) * 1983-09-24 1983-10-26 Scras Therapeutic compositions
SE462014B (sv) * 1983-09-28 1990-04-30 Gerhard Gergely Brusgranulat och foerfarande foer dess framstaellning
US4678661A (en) * 1983-09-28 1987-07-07 Gerhard Gergely Effervescent composition and method of making same
US4613497A (en) * 1984-02-29 1986-09-23 Health Products Development, Inc. Dry, water-foamable pharmaceutical compositions
GB8414221D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Unit dosage form
DE3440288A1 (de) * 1984-11-05 1986-05-07 Gergely, Gerhard, Dr.-Ing., Wien Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung
US4710384A (en) * 1986-07-28 1987-12-01 Avner Rotman Sustained release tablets made from microcapsules

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JPS61115023A (ja) 1986-06-02
HU195617B (en) 1988-06-28
FI91936B (fi) 1994-05-31
FI854303A (fi) 1986-05-06
CA1254143A (en) 1989-05-16
US4888177A (en) 1989-12-19
FI871951A0 (fi) 1987-05-04
JPS62501210A (ja) 1987-05-14
FI871951A (fi) 1987-05-04
ZA858306B (en) 1986-06-25
AU584154B2 (en) 1989-05-18
PT81425B (pt) 1987-11-11
JPH0753662B2 (ja) 1995-06-07
EP0232277B1 (de) 1990-01-17
FI91936C (fi) 1994-09-12
NZ214018A (en) 1988-07-28
EP0181564A1 (de) 1986-05-21
ATE52690T1 (de) 1990-06-15
ES548517A0 (es) 1986-12-01
IL76890A (en) 1989-01-31
NO854391L (no) 1986-05-06
AU4931885A (en) 1986-05-15
RU1787029C (ru) 1993-01-07
EP0232277A1 (de) 1987-08-19
HUT38532A (en) 1986-06-30
HUT47842A (en) 1989-04-28
AU576399B2 (en) 1988-08-25
DE3440288A1 (de) 1986-05-07
DK499185A (da) 1986-05-06
AU5199086A (en) 1986-06-03
DD238529A5 (de) 1986-08-27
ES8701492A1 (es) 1986-12-01
HU201868B (en) 1991-01-28
DE3577655D1 (de) 1990-06-21
JPH0434966B2 (de) 1992-06-09
US4762702A (en) 1988-08-09
FI854303A0 (fi) 1985-11-01
EP0181564B1 (de) 1990-05-16
EG19056A (en) 1994-10-30
IL76890A0 (en) 1986-02-28
WO1986002834A1 (fr) 1986-05-22
DE3575376D1 (de) 1990-02-22
PT81425A (de) 1985-12-01
GR852650B (de) 1986-03-04
DK499185D0 (da) 1985-10-30

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