DE3571615D1 - Process for epimerization at c6 of 3,4,5,6-tetra-hydro-2h-pyran-2-one - Google Patents
Process for epimerization at c6 of 3,4,5,6-tetra-hydro-2h-pyran-2-oneInfo
- Publication number
- DE3571615D1 DE3571615D1 DE8585107018T DE3571615T DE3571615D1 DE 3571615 D1 DE3571615 D1 DE 3571615D1 DE 8585107018 T DE8585107018 T DE 8585107018T DE 3571615 T DE3571615 T DE 3571615T DE 3571615 D1 DE3571615 D1 DE 3571615D1
- Authority
- DE
- Germany
- Prior art keywords
- epimerization
- pyran
- hydro
- tetra
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/619,506 US4588820A (en) | 1984-06-11 | 1984-06-11 | Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3571615D1 true DE3571615D1 (en) | 1989-08-24 |
Family
ID=24482190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585107018T Expired DE3571615D1 (en) | 1984-06-11 | 1985-06-07 | Process for epimerization at c6 of 3,4,5,6-tetra-hydro-2h-pyran-2-one |
Country Status (5)
Country | Link |
---|---|
US (1) | US4588820A (de) |
EP (1) | EP0164698B1 (de) |
JP (1) | JPS611681A (de) |
CA (1) | CA1228591A (de) |
DE (1) | DE3571615D1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4904646A (en) * | 1987-05-22 | 1990-02-27 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-COA reductase inhibitors |
US5091378A (en) * | 1987-05-22 | 1992-02-25 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method |
US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
US5506219A (en) * | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
US20010006644A1 (en) | 1997-07-31 | 2001-07-05 | David J. Bova | Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night |
KR100407758B1 (ko) | 2001-08-27 | 2003-12-01 | 씨제이 주식회사 | 스타틴의 제조에 있어서 락톤화 방법 |
TWI332953B (en) | 2002-02-08 | 2010-11-11 | Mitsubishi Rayon Co | Method for preparing lactone |
US7889176B2 (en) | 2006-07-18 | 2011-02-15 | Avago Technologies General Ip (Singapore) Pte. Ltd. | Capacitive sensing in displacement type pointing devices |
KR100836960B1 (ko) | 2007-09-07 | 2008-06-10 | 주식회사 서울제약 | 새로운 나이아신 제어방출형 제제 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53147073A (en) * | 1977-05-24 | 1978-12-21 | Sankyo Co Ltd | Mevalonolactone derivatives |
IL60751A (en) * | 1979-08-17 | 1985-04-30 | Merck & Co Inc | 6-(2'-((substituted phenyl)ethyl and-ethenyl)-4-hydroxy-tetrahydro-2h-pyran-2-one derivatives,their preparation and pharmaceutical compositions containing them |
US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
EP0068038B1 (de) * | 1981-06-29 | 1985-09-25 | Merck & Co. Inc. | (+)-(4R.6S)-(E)-6-(2-(4'-Fluor-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-on, Verfahren zu seiner Herstellung und eine diese Verbindung enthaltende pharmazeutische Zusammensetzung |
-
1984
- 1984-06-11 US US06/619,506 patent/US4588820A/en not_active Expired - Fee Related
-
1985
- 1985-06-05 CA CA000483265A patent/CA1228591A/en not_active Expired
- 1985-06-07 DE DE8585107018T patent/DE3571615D1/de not_active Expired
- 1985-06-07 EP EP85107018A patent/EP0164698B1/de not_active Expired
- 1985-06-11 JP JP60125282A patent/JPS611681A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS611681A (ja) | 1986-01-07 |
EP0164698A2 (de) | 1985-12-18 |
US4588820A (en) | 1986-05-13 |
EP0164698A3 (en) | 1986-11-20 |
EP0164698B1 (de) | 1989-07-19 |
CA1228591A (en) | 1987-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |