DE3581577D1 - 1h-indol-3-yl enthaltende 1,3-dimethyl-1-h-purine-2,6-dione. - Google Patents

1h-indol-3-yl enthaltende 1,3-dimethyl-1-h-purine-2,6-dione.

Info

Publication number
DE3581577D1
DE3581577D1 DE8585201484T DE3581577T DE3581577D1 DE 3581577 D1 DE3581577 D1 DE 3581577D1 DE 8585201484 T DE8585201484 T DE 8585201484T DE 3581577 T DE3581577 T DE 3581577T DE 3581577 D1 DE3581577 D1 DE 3581577D1
Authority
DE
Germany
Prior art keywords
indol
purine
dimethyl
compounds
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585201484T
Other languages
English (en)
Inventor
Ludo Edmond Josephine Kennis
Jan Vandenberk
Jozef Martin Boey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE3581577D1 publication Critical patent/DE3581577D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
DE8585201484T 1984-10-01 1985-09-18 1h-indol-3-yl enthaltende 1,3-dimethyl-1-h-purine-2,6-dione. Expired - Fee Related DE3581577D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/656,561 US4548939A (en) 1984-10-01 1984-10-01 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones

Publications (1)

Publication Number Publication Date
DE3581577D1 true DE3581577D1 (de) 1991-03-07

Family

ID=24633577

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585201484T Expired - Fee Related DE3581577D1 (de) 1984-10-01 1985-09-18 1h-indol-3-yl enthaltende 1,3-dimethyl-1-h-purine-2,6-dione.

Country Status (17)

Country Link
US (1) US4548939A (de)
EP (1) EP0177087B1 (de)
JP (1) JPH0653742B2 (de)
CN (1) CN1011311B (de)
AT (1) ATE60604T1 (de)
AU (1) AU576386B2 (de)
CA (1) CA1262348A (de)
DE (1) DE3581577D1 (de)
DK (1) DK163996C (de)
ES (1) ES8609324A1 (de)
FI (1) FI83220C (de)
GR (1) GR852375B (de)
IE (1) IE58747B1 (de)
NO (1) NO162069C (de)
NZ (1) NZ213498A (de)
PT (1) PT81229B (de)
ZA (1) ZA857553B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH648559A5 (de) * 1981-07-20 1985-03-29 Siegfried Ag Theophyllinderivate und verfahren zu deren herstellung.
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
IL87437A0 (en) * 1987-08-13 1989-01-31 Glaxo Group Ltd Indole derivatives,their preparation and pharmaceutical compositions containing them
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DK733788A (da) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 6507 Ingelheim, De
DK292A (da) * 1991-11-29 1992-01-02 Tanisake Kk Middel
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
CA2691468C (en) * 2007-06-22 2017-05-09 Hydra Biosciences, Inc. Substituted xanthine compounds and methods to treat diseases mediated by trpa1
US8318728B2 (en) 2008-05-14 2012-11-27 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries
WO2009140517A1 (en) 2008-05-14 2009-11-19 Hydra Biosciences, Inc. Compounds and compositions for treating chemical warfare agent-induced injuries

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
EP0011399A1 (de) * 1978-11-11 1980-05-28 FISONS plc N-Substituierte Theophylline, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE2922159A1 (de) * 1979-05-31 1980-12-04 Boehringer Mannheim Gmbh Neue xanthin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4426383A (en) * 1980-09-04 1984-01-17 Eisai Co., Ltd. Theophylline and theobromine derivatives
US4359468A (en) * 1981-02-25 1982-11-16 Boehringer Ingelheim Ltd. Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
CH648559A5 (de) * 1981-07-20 1985-03-29 Siegfried Ag Theophyllinderivate und verfahren zu deren herstellung.

Also Published As

Publication number Publication date
US4548939A (en) 1985-10-22
IE852403L (en) 1986-04-01
DK163996C (da) 1992-09-21
ATE60604T1 (de) 1991-02-15
DK444085D0 (da) 1985-09-30
CA1262348A (en) 1989-10-17
AU4812485A (en) 1986-04-10
JPS6187681A (ja) 1986-05-06
FI83220C (fi) 1991-06-10
FI853763A0 (fi) 1985-09-30
CN85105804A (zh) 1986-10-22
EP0177087A2 (de) 1986-04-09
AU576386B2 (en) 1988-08-25
JPH0653742B2 (ja) 1994-07-20
NO162069B (no) 1989-07-24
PT81229A (en) 1985-11-01
NO853856L (no) 1986-04-02
IE58747B1 (en) 1993-11-03
GR852375B (de) 1986-01-31
FI83220B (fi) 1991-02-28
FI853763L (fi) 1986-04-02
ZA857553B (en) 1987-05-27
NO162069C (no) 1989-11-01
CN1011311B (zh) 1991-01-23
PT81229B (pt) 1987-11-30
EP0177087A3 (en) 1986-06-11
EP0177087B1 (de) 1991-01-30
NZ213498A (en) 1988-04-29
DK163996B (da) 1992-04-27
ES8609324A1 (es) 1986-07-16
ES547447A0 (es) 1986-07-16
DK444085A (da) 1986-04-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee