DE3682502D1 - Verfahren und geraete zur trennung, vermischung und bestimmung von komponenten in spezifischen bindungstests. - Google Patents

Verfahren und geraete zur trennung, vermischung und bestimmung von komponenten in spezifischen bindungstests.

Info

Publication number
DE3682502D1
DE3682502D1 DE8686905538T DE3682502T DE3682502D1 DE 3682502 D1 DE3682502 D1 DE 3682502D1 DE 8686905538 T DE8686905538 T DE 8686905538T DE 3682502 T DE3682502 T DE 3682502T DE 3682502 D1 DE3682502 D1 DE 3682502D1
Authority
DE
Germany
Prior art keywords
devices
specific binding
separating
mixing
label
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686905538T
Other languages
English (en)
Inventor
William Rudolph Hargreaves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotope Inc
Original Assignee
Biotope Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotope Inc filed Critical Biotope Inc
Application granted granted Critical
Publication of DE3682502D1 publication Critical patent/DE3682502D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021Test tubes specially adapted for centrifugation purposes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/5375Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by changing the physical or chemical properties of the medium or immunochemicals, e.g. temperature, density, pH, partitioning
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/806Electrical property or magnetic property
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/824Immunological separation techniques
DE8686905538T 1985-08-21 1986-08-21 Verfahren und geraete zur trennung, vermischung und bestimmung von komponenten in spezifischen bindungstests. Expired - Fee Related DE3682502D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76810885A 1985-08-21 1985-08-21
PCT/US1986/001720 WO1987001206A1 (en) 1985-08-21 1986-08-21 Methods and devices for separating, mixing, and detecting components in specific binding assays

Publications (1)

Publication Number Publication Date
DE3682502D1 true DE3682502D1 (de) 1991-12-19

Family

ID=25081541

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686905538T Expired - Fee Related DE3682502D1 (de) 1985-08-21 1986-08-21 Verfahren und geraete zur trennung, vermischung und bestimmung von komponenten in spezifischen bindungstests.

Country Status (8)

Country Link
US (1) US4868130A (de)
EP (1) EP0233939B1 (de)
JP (1) JP2591738B2 (de)
KR (1) KR880700269A (de)
AT (1) ATE69507T1 (de)
CA (1) CA1292092C (de)
DE (1) DE3682502D1 (de)
WO (1) WO1987001206A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073341A (en) * 1985-08-21 1991-12-17 Biotope, Inc. Devices for conducting specific binding assays
US5470711A (en) * 1986-03-26 1995-11-28 Synbiotics Corporation Saliva enhancement reagent for feline leukemia virus elisa
SE8703733L (sv) * 1987-09-28 1989-03-29 Ragnar Soedergaard Analysmetod foer bestaemning av procent fri substans i biologiska vaetskor genom jaemviktsfoerdelning i olja/vatten system
JP2854058B2 (ja) * 1987-12-01 1999-02-03 ベーリンガー マンヘイム コーポレイション アッセイを実施するための方法及び装置
US5145784A (en) * 1988-05-04 1992-09-08 Cambridge Biotech Corporation Double capture assay method employing a capillary flow device
US5484735A (en) * 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
CA2033010A1 (en) * 1989-12-22 1991-06-23 Rajeev Ramanathan Method for separating components in a mixture
US5279936A (en) * 1989-12-22 1994-01-18 Syntex (U.S.A.) Inc. Method of separation employing magnetic particles and second medium
US5223393A (en) * 1990-06-12 1993-06-29 Microgenics Corporation Detection of analytes having binding sites for at least two binding moieties
US6703236B2 (en) * 1990-11-29 2004-03-09 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
KR100236506B1 (ko) * 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5506114A (en) * 1992-02-07 1996-04-09 Osborn Laboratories Methods and kits for detecting the presence or concentration of biological analytes
US5629168A (en) * 1992-02-10 1997-05-13 British Technology Group Limited Chemiluminescent enhancers
GB2312746B (en) * 1996-04-24 2000-07-19 Molecular Light Technology Lim Detection of an analyte in a Water Immiscible Solvent
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6030582A (en) * 1998-03-06 2000-02-29 Levy; Abner Self-resealing, puncturable container cap
US6752965B2 (en) * 1998-03-06 2004-06-22 Abner Levy Self resealing elastomeric closure
JP3662850B2 (ja) * 1998-06-24 2005-06-22 イルミナ インコーポレイテッド 微小球を有するアレイセンサーのデコード
CA2283597C (en) 1998-10-02 2008-02-05 Ortho-Clinical Diagnostics, Inc. Reduced cortisol conjugates
EP1183104B1 (de) 1999-05-14 2006-10-25 Gen-Probe Incorporated Durchdringbare kappe mit innerer spitze
US6623982B1 (en) * 1999-07-12 2003-09-23 Immunivest Corporation Increased separation efficiency via controlled aggregation of magnetic nanoparticles
EP1384076B1 (de) 2001-03-19 2012-07-25 Gyros Patent Ab Charakterisierung von reaktionsvariablen
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
US20050181513A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by MAILDI mass spectrometry
US7776531B1 (en) 2004-03-25 2010-08-17 Illumina, Inc. Compositions and methods for stabilizing surface bound probes
KR101228356B1 (ko) 2004-04-08 2013-02-05 바이오매트리카 인코포레이티드 생명과학용 시료 보관 및 시료 관리의 통합
US9488665B2 (en) * 2005-09-13 2016-11-08 Chrome Red Technologies, Llc Magnetic particle tagged reagents and techniques
US20070113908A1 (en) * 2005-11-18 2007-05-24 The Ohio State University And Bioloc, Inc. Valve for microfluidic chips
US9274082B2 (en) * 2007-08-27 2016-03-01 Technion Research & Development Foundation Limited pH gradients controlled by electrolysis, and their use in isoelectric focusing
RU2533252C2 (ru) * 2008-10-31 2014-11-20 Биомерьё, Инк. Способы разделения и характеристики микроорганизмов с помощью идентификатора
JP5816164B2 (ja) * 2009-05-07 2015-11-18 ビオメリュー・インコーポレイテッド 抗生物質耐性測定方法
US20100323343A1 (en) * 2009-05-11 2010-12-23 Nexus Dx, Inc. Methods and compositions for analyte detection
CN102472724B (zh) 2009-08-18 2014-08-13 工业研究与发展基金会有限公司 分离分子分析物的方法和装置
WO2011021196A2 (en) 2009-08-18 2011-02-24 Technion Research & Development Foundation Ltd. Proton concentration topographies, methods and devices for producing the same
CA2784791A1 (en) * 2009-12-17 2011-07-14 Abaxis, Inc. Novel assays for detecting analytes in samples and kits and compositions related thereto
EP2598660B1 (de) 2010-07-26 2017-03-15 Biomatrica, INC. Zusammensetzungen zur stabilisierung von dna, rna und proteinen in blut- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen
EP2598661B1 (de) 2010-07-26 2017-09-27 Biomatrica, INC. Zusammensetzungen zur stabilisierung von dna, rna und proteinen in speichel- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen
US20130071946A1 (en) * 2011-09-21 2013-03-21 Roche Molecular Systems, Inc. Suspension Container For Binding Particles For The Isolation Of Biological Material
US20130164860A1 (en) * 2011-11-04 2013-06-27 Technion Research & Development Foundation Ltd. Affinity methods and compositions employing electronic control of ph
CN104023551A (zh) 2011-11-04 2014-09-03 生物辐射实验室股份有限公司 细胞组分的同时纯化
US9766207B2 (en) 2011-11-04 2017-09-19 Bio-Rad Laboratories, Inc. Affinity methods and compositions employing electronic control of pH
EP2814597A4 (de) 2012-02-15 2015-10-28 Bio Rad Laboratories Elektronische steuerung von ph-wert und ionenstärke
US9321012B2 (en) 2012-04-04 2016-04-26 Bio-Rad Laboratories, Inc. Electronic protein fractionation
US20130280146A1 (en) * 2012-04-18 2013-10-24 Rarecyte, Inc. Systems and methods for separation and analysis of target analytes
EP2934572A4 (de) 2012-12-20 2016-11-23 Biomatrica Inc Formulierungen und verfahren zur stabilisierung von pcr-reagenzien
US10364453B1 (en) * 2013-02-04 2019-07-30 The United States Of America, As Represented By The Secretary Of The Navy Detecting of bacteria using fluorescently-labeled phage immobilized on an optically transparent surface
WO2014144209A1 (en) 2013-03-15 2014-09-18 Abbott Molecular Inc. One-step procedure for the purification of nucleic acids
EP3942931A1 (de) 2014-06-10 2022-01-26 Biomatrica, INC. Stabilisierung von thrombozyten bei umgebungstemperatur
EP3387411B1 (de) 2015-12-08 2023-05-10 Biomatrica, INC. Verringerung der erythrozytensedimentationsrate
CA3010823C (en) * 2016-01-08 2021-01-26 Siemens Healthcare Diagnostics Inc. Heating element for sensor array
IT201600079328A1 (it) * 2016-07-28 2018-01-28 Altergon Sa Metodo migliorato per la decontaminazione di materiale biologico mediante partizione e inattivazione

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1411382A (en) * 1971-12-16 1975-10-22 Radiochemical Centre Ltd Methods of analysis
US3852194A (en) * 1972-12-11 1974-12-03 Corning Glass Works Apparatus and method for fluid collection and partitioning
GB1566098A (en) * 1975-11-14 1980-04-30 Nat Res Dev Separation of solid and liquid components of mixtures
GB1533272A (en) * 1976-02-13 1978-11-22 Radiochemical Centre Ltd Centrifuge tube
IL56839A0 (en) * 1979-03-11 1979-05-31 Technion Res & Dev Foundation Improvement in specific binding assay technique
IL58943A (en) * 1979-12-12 1983-05-15 Cais Michael Method and device for mass transfer operations in immunoassays and other applications
JPS58205854A (ja) * 1982-05-25 1983-11-30 Mihama Hisaharu 潜血反応検査用の固定化抗体
DE3222962A1 (de) * 1982-06-19 1983-12-22 Bayer Ag, 5090 Leverkusen Siliconpasten fuer die trennung von blutproben
AU1912783A (en) * 1982-09-15 1984-03-22 Ortho Diagnostic Systems Inc. Carousel microparticle separating, washing + reading device
FI844027A (fi) * 1984-10-12 1986-04-13 Labsystems Oy Immunologiskt bestaemningsfoerfarande.

Also Published As

Publication number Publication date
EP0233939B1 (de) 1991-11-13
ATE69507T1 (de) 1991-11-15
KR880700269A (ko) 1988-02-22
JPS63501172A (ja) 1988-04-28
JP2591738B2 (ja) 1997-03-19
CA1292092C (en) 1991-11-12
WO1987001206A1 (en) 1987-02-26
EP0233939A1 (de) 1987-09-02
US4868130A (en) 1989-09-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee