DE3688613T2 - Polychelierende stoffe für abbildung- und spektralerhöhung (und spektrale verschiebung). - Google Patents

Polychelierende stoffe für abbildung- und spektralerhöhung (und spektrale verschiebung).

Info

Publication number
DE3688613T2
DE3688613T2 DE86907195T DE3688613T DE3688613T2 DE 3688613 T2 DE3688613 T2 DE 3688613T2 DE 86907195 T DE86907195 T DE 86907195T DE 3688613 T DE3688613 T DE 3688613T DE 3688613 T2 DE3688613 T2 DE 3688613T2
Authority
DE
Germany
Prior art keywords
image
enhancing
agents
spectral
chelating agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE86907195T
Other languages
English (en)
Other versions
DE3688613D1 (de
Inventor
David F Ranney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abeona Therapeutics Inc
Original Assignee
Access Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25176678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3688613(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Access Pharmaceuticals Inc filed Critical Access Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3688613D1 publication Critical patent/DE3688613D1/de
Publication of DE3688613T2 publication Critical patent/DE3688613T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/12Macromolecular compounds
    • A61K49/126Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/06Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255Granulates, agglomerates, microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
DE86907195T 1985-11-18 1986-11-18 Polychelierende stoffe für abbildung- und spektralerhöhung (und spektrale verschiebung). Revoked DE3688613T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79975785A 1985-11-18 1985-11-18

Publications (2)

Publication Number Publication Date
DE3688613D1 DE3688613D1 (de) 1993-07-29
DE3688613T2 true DE3688613T2 (de) 1994-01-13

Family

ID=25176678

Family Applications (1)

Application Number Title Priority Date Filing Date
DE86907195T Revoked DE3688613T2 (de) 1985-11-18 1986-11-18 Polychelierende stoffe für abbildung- und spektralerhöhung (und spektrale verschiebung).

Country Status (8)

Country Link
US (1) US5155215A (de)
EP (1) EP0247156B1 (de)
JP (1) JPH07110815B2 (de)
AT (1) ATE90879T1 (de)
AU (1) AU6621586A (de)
CA (1) CA1280364C (de)
DE (1) DE3688613T2 (de)
WO (1) WO1987002893A1 (de)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE74279T1 (de) * 1986-04-07 1992-04-15 Francois Dietlin In der tomo-densitometrie zu verwendende zusammensetzungen.
US4863713A (en) * 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
US5055288A (en) * 1987-06-26 1991-10-08 Advanced Magnetics, Inc. Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
US5672334A (en) * 1991-01-16 1997-09-30 Access Pharmaceuticals, Inc. Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
MX12394A (es) * 1987-07-23 1993-12-01 Ciba Geigy Ag Procedimiento par la obtencion de carbamatos de polietilenglicol.
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
AU623901B2 (en) * 1988-01-26 1992-05-28 Nycomed As Paramagnetic compounds comprising chelating moiety, linker group macro molecule and paramagnetic metal
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
US5260050A (en) * 1988-09-29 1993-11-09 Ranney David F Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes
EP0361960A3 (de) * 1988-09-29 1992-01-02 RANNEY, David F. Verfahren und Vorrichtung zur Bilderzeugung mittels magnetischer Resonanz
US6274713B1 (en) * 1989-04-07 2001-08-14 Salutar, Inc. Polychelants
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
FR2654344B1 (fr) * 1989-11-16 1994-09-23 Cis Bio Int Complexe paramagnetique de gadolinium, son procede de preparation et son utilisation pour le diagnostic par irm.
IT1245748B (it) * 1990-12-21 1994-10-14 Mini Ricerca Scient Tecnolog Preparazione includente anticorpi monoclonali biotinilati, avidina e biotina, per la diagnosi di affezioni tumorali e suo impiego
DE4117782C2 (de) * 1991-05-28 1997-07-17 Diagnostikforschung Inst Nanokristalline magnetische Eisenoxid-Partikel, Verfahren zu ihrer Herstellung sowie diagnostische und/oder therapeutische Mittel
JP2901787B2 (ja) * 1991-07-15 1999-06-07 日本メジフィジックス株式会社 核磁気共鳴造影剤
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
DE69230885T3 (de) * 1991-09-17 2008-01-24 Ge Healthcare As Gasförmige ultraschallkontrastmittel
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
JP2894879B2 (ja) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 診断用造影剤
GB9200065D0 (en) * 1992-01-03 1992-02-26 Nycomed As Contrast media
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
JP3337075B2 (ja) * 1992-08-05 2002-10-21 名糖産業株式会社 小粒子径水溶性カルボキシ多糖−磁性酸化鉄複合体
US5466439A (en) * 1992-11-12 1995-11-14 Magnetic Research, Inc. Polymeric contrast enhancing agents for magnetic resonance images
US5330743A (en) * 1992-11-12 1994-07-19 Magnetic Research, Inc. Aminosaccharide contrast agents for magnetic resonance images
EP0680341B1 (de) * 1993-01-25 2001-05-09 Sonus Pharmaceuticals, Inc. Phase-Stift Kolloide zur Verwendung als Ultraschallkontrastmittel
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
WO1994017829A1 (en) * 1993-02-02 1994-08-18 Neorx Corporation Directed biodistribution of small molecules
US6203775B1 (en) * 1993-03-19 2001-03-20 The General Hospital Corporation Chelating polymers for labeling of proteins
US5482698A (en) * 1993-04-22 1996-01-09 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin polymer conjugates
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
ES2231775T5 (es) 1993-07-30 2011-02-02 Imcor Pharmaceutical Co. Composición de microburbujas estabilizadas para ecografía.
ITMI940055A1 (it) * 1994-01-18 1995-07-18 Bracco Spa Contenitore per soluzioni contrastografiche diagnostiche
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
WO1996010359A1 (en) * 1994-10-03 1996-04-11 The Trustees Of The University Of Pennsylvania Chelate complex with high conspicuity for magnetic resonance imaging
US6232295B1 (en) 1994-10-12 2001-05-15 Jon Faiz Kayyem Cell-specific contrast agent and gene delivery vehicles
US6962686B2 (en) * 1994-10-12 2005-11-08 California Institute Of Technology Cell-specific gene delivery vehicles
ZA958789B (en) * 1994-10-21 1996-05-29 Nihon Mediphysics Co Ltd Diagnostic imaging agent
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5707605A (en) * 1995-06-02 1998-01-13 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5980862A (en) * 1995-06-02 1999-11-09 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
DK0904113T3 (da) * 1996-03-05 2004-08-30 Acusphere Inc Mikroindkapslede fluorerede gasser til anvendelse som billeddannende midler
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
GB9705521D0 (en) * 1997-03-18 1997-05-07 Univ Sheffield The use of mononuclear phagocytes in the vivo imaging of hypoxic/ischaemic tissue
EP0885616A1 (de) * 1997-06-20 1998-12-23 Schering Aktiengesellschaft Verwendung von intravenösen Kontrastmitteln sowie Vorrichtungen für die Projektionsmammographie
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
AU752812B2 (en) 1997-11-17 2002-10-03 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
DE19758118A1 (de) * 1997-12-17 1999-07-01 Schering Ag Polyrotaxane
US6113880A (en) * 1997-12-17 2000-09-05 Schering Aktiengesellschaft Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging
US6537520B1 (en) * 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6524553B2 (en) * 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
NZ511677A (en) 1998-12-18 2003-10-31 Du Pont Pharm Co Vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) * 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
TR200101757T2 (tr) * 1998-12-18 2001-12-21 Dupont Pharmaceuticais Company Vitronektin reseptör antagonisti farmasötikler
US6569402B1 (en) * 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6409987B1 (en) 1999-04-07 2002-06-25 Intimax Corporation Targeted agents useful for diagnostic and therapeutic applications
HUP0202635A3 (en) * 1999-07-29 2006-03-28 Epix Medical Inc Cambridge Targeting multimeric imaging agents through multilocus binding
US6685914B1 (en) * 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US6656448B1 (en) 2000-02-15 2003-12-02 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
AU2001261728A1 (en) * 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
NZ516746A (en) * 2000-06-01 2004-02-27 Bristol Myers Squibb Pharma Lactams substituted by cyclic succinates as inhibitors of A-beta protein production
AU2001276956A1 (en) 2000-07-17 2002-01-30 California Institute Of Technology Macrocyclic mri contrast agents
WO2002026267A2 (en) * 2000-09-25 2002-04-04 The Procter & Gamble Company Manganes complexes for magnetic resonance imaging
AU2002211517A1 (en) 2000-10-04 2002-04-15 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
IL145723A0 (en) * 2000-10-11 2002-07-25 Nihon Mediphysics Co Ltd Process for producing an amide compound
US6776977B2 (en) * 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
US6869590B2 (en) * 2001-02-23 2005-03-22 Bristol-Myers Squibb Pharma Company Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20020197648A1 (en) * 2001-05-02 2002-12-26 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20030135108A1 (en) * 2001-05-02 2003-07-17 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20090062256A1 (en) * 2001-06-01 2009-03-05 Bristol-Myers Squibb Pharma Company LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
US6797257B2 (en) * 2001-06-26 2004-09-28 The Board Of Trustees Of The University Of Illinois Paramagnetic polymerized protein microspheres and methods of preparation thereof
TWI221406B (en) * 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
CA2452478A1 (en) * 2001-08-08 2003-02-20 Bristol-Myers Squibb Pharma Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
DE10141106A1 (de) * 2001-08-22 2003-03-13 Aventis Pharma Gmbh Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen
CN101249269A (zh) 2002-01-24 2008-08-27 巴内斯-朱威胥医院 整联蛋白靶向的影像剂
ATE373644T1 (de) * 2002-02-05 2007-10-15 Bristol Myers Squibb Co N-substituierte 3-hydroxy-4-pyridinone und diese enthaltende pharmazeutika
US20030198597A1 (en) * 2002-04-22 2003-10-23 Meade Thomas J. Novel macrocyclic activatible magnetic resonance imaging contrast agents
US20060115431A1 (en) * 2002-07-22 2006-06-01 Bracco Imaging S.P.A. Procedures of cellular labelling with paramagnetic complexes for mri applications
US20040022857A1 (en) * 2002-07-31 2004-02-05 Uzgiris Egidijus E. Synthesis of highly conjugated polymers
EP1587547A2 (de) * 2003-01-22 2005-10-26 The General Hospital Corporation Amyloid-bindung, metallchelat-bildner
ITPD20030174A1 (it) * 2003-07-31 2003-10-29 Univ Padova Coniugati polimerici per diagnostica e terapia
US20050079131A1 (en) * 2003-08-08 2005-04-14 Lanza Gregory M. Emulsion particles for imaging and therapy and methods of use thereof
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
US20050136003A1 (en) * 2003-10-31 2005-06-23 Casebier David S. Novel chemical agents comprising a cardiotonic moiety and an imaging moiety and methods of their use
US20050106101A1 (en) * 2003-10-31 2005-05-19 Ajay Purohit Novel chemical agents comprising an adenosine moiety or an adenosine analog moiety and an imaging moiety and methods of their use
CN100528076C (zh) * 2003-12-08 2009-08-19 西门子公司 通过顺磁性水溶材料来降低冷却剂的弛豫时间的应用
US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
US8128908B2 (en) * 2004-04-30 2012-03-06 University Of Florida Research Foundation, Inc. Nanoparticles and their use for multifunctional bioimaging
US20060088475A1 (en) * 2004-05-10 2006-04-27 Northwestern University Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
EP1768558A4 (de) 2004-06-09 2009-11-25 Kereos Inc Lipophile derivate von chelat-monoamiden
US20060083681A1 (en) * 2004-10-18 2006-04-20 Ajay Purohit Compounds for myocardial perfusion imaging
ATE412691T1 (de) 2005-01-13 2008-11-15 Cinv Ag Kohlenstoffnanopartikel enthaltende verbundwerkstoffe
WO2006124726A2 (en) 2005-05-12 2006-11-23 The General Hospital Corporation Novel biotinylated compositions
CN101252954A (zh) * 2005-06-30 2008-08-27 布里斯托尔-迈尔斯斯奎布药品公司 作为显像剂的酰肼偶联物
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
WO2007045616A1 (en) * 2005-10-18 2007-04-26 Cinvention Ag Thermoset particles and methods for production thereof
WO2007070827A2 (en) * 2005-12-15 2007-06-21 Bristol-Myers Squibb Pharma Company Contrast agents for myocardium perfusion imaging
WO2007124131A2 (en) * 2006-04-20 2007-11-01 The University Of North Carolina At Chapel Hill Hybrid nanomaterials as multimodal imaging contrast agents
AU2007244705A1 (en) * 2006-04-27 2007-11-08 Barnes-Jewish Hospital Detection and imaging of target tissue
WO2008003682A1 (en) * 2006-07-06 2008-01-10 Novartis Ag Non invasive method for assessing mucus clearance
BRPI0806916A2 (pt) * 2007-01-19 2014-04-29 Cinv Ag Implante poroso, não degradável feito por moldagem de pó
US20080206862A1 (en) * 2007-02-28 2008-08-28 Cinvention Ag High surface cultivation system bag
WO2008104588A1 (en) * 2007-02-28 2008-09-04 Cinvention Ag High surface cultivation system
EP2072060A1 (de) 2007-12-18 2009-06-24 Institut Curie Verfahren und Zusammensetzungen zur Herstellung und Verwendung von Toxinkonjugaten
JP5730581B2 (ja) 2008-01-08 2015-06-10 ランセウス メディカル イメージング, インコーポレイテッド 造影剤としてのn−アルコキシアミド抱合体
EP2257315B1 (de) 2008-02-29 2019-10-23 Lantheus Medical Imaging, Inc. Kontrastmittel für anwendungen einschliesslich perfusionsbildgebung
US8580231B2 (en) 2008-05-23 2013-11-12 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
US20100029909A1 (en) * 2008-05-23 2010-02-04 Northwestern University Compositions and methods comprising magnetic resonance contrast agents
DE102008024976A1 (de) 2008-05-23 2009-12-17 Marvis Technologies Gmbh Medizinisches Instrument
JP5681102B2 (ja) 2008-05-30 2015-03-04 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドSiemens Medical Solutions USA,Inc. 分子イメージング手法のための化合物
EP3156078B1 (de) 2009-04-10 2020-03-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Fucoidane als liganden zur diagnose degenerativer pathologien
LT2419096T (lt) 2009-04-15 2020-04-10 Lantheus Medical Imaging, Inc. Radiofarmacinės kompozicijos stabilizavimas naudojant askorbo rūgštį
EP2451776B1 (de) 2009-07-08 2019-09-18 Lantheus Medical Imaging, Inc. N-alkoxyamidkonjugate als bildgebungsmittel
PT2534136T (pt) 2010-02-08 2017-12-15 Lantheus Medical Imaging Inc Métodos para sintetizar agentes de imagiologia, e seus intermediários
EP2450067A1 (de) 2010-10-18 2012-05-09 MaRVis Technologies GmbH Medizinische Vorrichtung
US9272054B2 (en) 2010-12-03 2016-03-01 Institut National De La Sante Et De La Recherche Medicale (Inserm) Agents for the molecular imaging of serine-protease in human pathologies
US9598499B2 (en) 2010-12-30 2017-03-21 Institut National De La Santé Et De La Recherche Médicale (Inserm) Antigen binding formats for use in therapeutic treatments or diagnostic assays
EP2484388A1 (de) 2011-02-05 2012-08-08 MaRVis Technologies GmbH Implantierbare oder einsetzbare, mittels MRT erkennbare medizinische Vorrichtung mit einer Beschichtung, die paramagnetische Ionen umfasst, und Verfahren zu deren Herstellung
WO2013058345A1 (ja) * 2011-10-21 2013-04-25 国立大学法人 長崎大学 68Ge-68Gaジェネレータ用のGe吸着剤
US20150337308A1 (en) 2012-04-11 2015-11-26 Chu De Bordeaux Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
EP2692365A1 (de) 2012-08-03 2014-02-05 MaRVis Medical GmbH Implantierbare oder einsetzbare, mittels MRT erkennbare medizinische Vorrichtung mit einer Beschichtung, die paramagnetische Ionen umfasst, und Verfahren zu deren Herstellung
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CA2883130A1 (en) 2012-08-31 2014-03-06 The General Hospital Corporation Biotin complexes for treatment and diagnosis of alzheimer's disease
EP2733153A1 (de) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Herstellung von Immunkonjugaten und Verwendungen davon
US11207429B2 (en) * 2014-05-09 2021-12-28 Arizona Board Of Regents On Behalf Of The University Of Arizona Method and compositions for orally administered contrast agents for MR imaging
US11382990B2 (en) 2016-11-16 2022-07-12 The Usa, As Represented By The Secretary, Dhhs Imageable polymers, methods of making and methods of use thereof
US11607462B2 (en) 2017-05-16 2023-03-21 Northwestern University Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury
WO2021172030A1 (ja) * 2020-02-28 2021-09-02 国立大学法人九州大学 組成物、動的核偏極用組成物、高偏極化組成物、物質の高偏極化方法、高偏極化した物質およびnmr測定方法
WO2021189052A1 (en) * 2020-03-20 2021-09-23 Robert Taub Composition for radiation treatment of intracavitary or metastatic deposits of malignancy and method for treatment therewith

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2740170C2 (de) * 1977-05-17 1982-02-04 Tabushi, Iwao, Kyoto Alkylsubstituierte cyclische Tetraalkylentetramine
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
US4370476A (en) * 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4432987A (en) * 1982-04-23 1984-02-21 Pfizer Inc. Crystalline benzenesulfonate salts of sultamicillin
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4731239A (en) * 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4423158A (en) * 1983-01-27 1983-12-27 Gelinnovation Handelsaktiebolag Ion adsorbent for metals having a coordination number greater than two
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
DE3316703A1 (de) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen Orales kontrastmittel fuer die kernspintomographie und dessen herstellung
GB8413849D0 (en) * 1984-05-31 1984-07-04 Amersham Int Plc Nmr contrast agents
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
SE465907B (sv) * 1984-11-01 1991-11-18 Nyegaard & Co As Diagnosticeringsmedel innehaallande en paramagnetisk metall
EP0184899B1 (de) * 1984-11-01 1990-04-18 Nycomed As Paramagnetische Kontrastmittel für die Anwendung in "in vivo" NMR-diagnostischen Methoden und die Herstellung davon
US4735210A (en) * 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
GB8525974D0 (en) * 1985-10-22 1985-11-27 Nyegaard & Co As Chemical substance
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
US4770183A (en) * 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
US4822594A (en) * 1987-01-27 1989-04-18 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
US4832877A (en) * 1987-09-28 1989-05-23 Exxon Research And Engineering Company Tetranuclear sulfido-bridged complex of Cr(III) having a strongly magnetic ground state

Also Published As

Publication number Publication date
EP0247156A1 (de) 1987-12-02
JPS63501798A (ja) 1988-07-21
AU6621586A (en) 1987-06-02
JPH07110815B2 (ja) 1995-11-29
ATE90879T1 (de) 1993-07-15
EP0247156B1 (de) 1993-06-23
WO1987002893A1 (en) 1987-05-21
CA1280364C (en) 1991-02-19
US5155215A (en) 1992-10-13
DE3688613D1 (de) 1993-07-29

Similar Documents

Publication Publication Date Title
DE3688613T2 (de) Polychelierende stoffe für abbildung- und spektralerhöhung (und spektrale verschiebung).
NO173767C (no) Magnetisk resonansbildeforsterkende blanding
DE69006164D1 (de) Paramagnetische Ölemulsion als MRI Kontrastmittel.
EP0275285A4 (de) Biodegradierbares superparamagnetisches material zur verwendung in klinischen anwendungen.
NO306721B1 (no) Avbildingspreparat ved kjernemagnetisk resonans omfattende et paramagnetisk metallchelat, samt mellomprodukt
FI854488A0 (fi) Kontrastmedel.
HK130797A (en) Novel magnetic resonance imaging agents
DE69120403D1 (de) Verwendung von superparamagnetischen Partikeln zur magnetometrischen Untersuchungen (SQUID)
MX9304624A (es) Compuestos poliazamacrociclicos para complejamien to de iones metalicos.
EA199800998A2 (ru) Хелатные соединения металлов с макроциклическими полиаминокарбоновыми соединениями и их использование для диагностических исследований
DE3869788D1 (de) Kontrastmittel fuer den gastrointestinaltrakt.
DE69116637D1 (de) Mittel zur magnetischen Resonanzabbildung
NO914170D0 (no) Fremgangsmaate for avbildning ved magnetisk resonans
RU92004359A (ru) Гидразоны
EP1033836A3 (de) Speziell ausgebildete Blechelemente zur Verbesserung der Ton- oder Bildqualität
DE69100842D1 (de) Unlösliche salze von lanthaniden zur bildlichen darstellung des magen-darmtrakts mittels nuklearmagnetischer resonanz.
Sakamoto et al. 5159550 Artifact suppression system for magnetic resonnance imaging apparatus
Sepponen 5159270 Imaging method

Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation