DE3784060T2 - Chirurgisches biokompositmaterial und dessen herstellung. - Google Patents

Chirurgisches biokompositmaterial und dessen herstellung.

Info

Publication number
DE3784060T2
DE3784060T2 DE8787907427T DE3784060T DE3784060T2 DE 3784060 T2 DE3784060 T2 DE 3784060T2 DE 8787907427 T DE8787907427 T DE 8787907427T DE 3784060 T DE3784060 T DE 3784060T DE 3784060 T2 DE3784060 T2 DE 3784060T2
Authority
DE
Germany
Prior art keywords
pct
surgical
production
composite material
organic composite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787907427T
Other languages
English (en)
Other versions
DE3784060D1 (de
Inventor
Pertti Toermaelae
Seppo Vainionpaeae
Pentti Rokkanen
Pertti Helevirta
Marja Pellinen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocon Oy
Original Assignee
Biocon Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Oy filed Critical Biocon Oy
Publication of DE3784060D1 publication Critical patent/DE3784060D1/de
Application granted granted Critical
Publication of DE3784060T2 publication Critical patent/DE3784060T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/129—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2803—Bones for mandibular reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30009—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in fibre orientations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30011—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30261—Three-dimensional shapes parallelepipedal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30594—Special structural features of bone or joint prostheses not otherwise provided for slotted, e.g. radial or meridian slot ending in a polar aperture, non-polar slots, horizontal or arcuate slots
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30929—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having at least two superposed coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30971—Laminates, i.e. layered products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0082—Three-dimensional shapes parallelepipedal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0028—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in fibre orientations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
DE8787907427T 1986-11-03 1987-11-03 Chirurgisches biokompositmaterial und dessen herstellung. Expired - Lifetime DE3784060T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI864457A FI80605C (fi) 1986-11-03 1986-11-03 Benkirurgisk biokompositmaterial.
PCT/FI1987/000147 WO1988003417A1 (en) 1986-11-03 1987-11-03 Surgical biocomposite material and a method for producing the material

Publications (2)

Publication Number Publication Date
DE3784060D1 DE3784060D1 (de) 1993-03-18
DE3784060T2 true DE3784060T2 (de) 1993-05-19

Family

ID=8523429

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787907427T Expired - Lifetime DE3784060T2 (de) 1986-11-03 1987-11-03 Chirurgisches biokompositmaterial und dessen herstellung.

Country Status (11)

Country Link
US (1) US5084051A (de)
EP (1) EP0289562B1 (de)
JP (1) JPH01501289A (de)
AT (1) ATE85225T1 (de)
AU (1) AU606903B2 (de)
CA (1) CA1297795C (de)
DE (1) DE3784060T2 (de)
ES (1) ES2005049A6 (de)
FI (1) FI80605C (de)
RU (1) RU1769715C (de)
WO (1) WO1988003417A1 (de)

Families Citing this family (269)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444113A (en) * 1988-08-08 1995-08-22 Ecopol, Llc End use applications of biodegradable polymers
US5767222A (en) * 1988-08-08 1998-06-16 Chronopol, Inc. Degradable polydioxaneone-based materials
US6171338B1 (en) * 1988-11-10 2001-01-09 Biocon, Oy Biodegradable surgical implants and devices
AU5154390A (en) * 1989-02-15 1990-09-05 Microtek Medical, Inc. Biocompatible material and prosthesis
SE465154B (sv) * 1990-02-06 1991-08-05 Lars Strid Tillvaextfaktor i samband med artificiella transplantat
US5386012A (en) * 1990-02-06 1995-01-31 Strid; Lars Growth factor in connection with artificial implants
US5062843A (en) * 1990-02-07 1991-11-05 Mahony Iii Thomas H Interference fixation screw with integral instrumentation
US6464713B2 (en) * 1990-06-28 2002-10-15 Peter M. Bonutti Body tissue fastening
US7208013B1 (en) 1990-06-28 2007-04-24 Bonutti Ip, Llc Composite surgical devices
CA2094908C (en) * 1990-12-06 2000-02-08 Byron Kent Hayes Implantable bioabsorbable article
CA2060635A1 (en) * 1991-02-12 1992-08-13 Keith D'alessio Bioabsorbable medical implants
DE59201996D1 (de) * 1991-03-11 1995-06-01 Straumann Inst Ag Hilfsmittel zum Befestigen und Halten einer Abdeckung an einem Kieferknochen.
ATE131373T1 (de) * 1991-05-24 1995-12-15 Synthes Ag Resorbierbare sehnen- und knochenverstärkungseinrichtung
US5383931A (en) * 1992-01-03 1995-01-24 Synthes (U.S.A.) Resorbable implantable device for the reconstruction of the orbit of the human skull
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
JPH07503869A (ja) * 1992-02-14 1995-04-27 ボード・オヴ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム 多相生侵食性の移植材料または担体並びにその製造および使用方法
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
FR2689400B1 (fr) * 1992-04-03 1995-06-23 Inoteb Materiau pour prothese osseuse contenant des particules de carbonate de calcium dispersees dans une matrice polymere bioresorbable.
US5545226A (en) * 1992-05-29 1996-08-13 Porex Technologies Corp. Implants for cranioplasty
DE4302708C2 (de) * 1993-02-01 1995-06-01 Kirsch Axel Abdeckmembran
DE4302709C1 (de) * 1993-02-01 1994-07-28 Kirsch Axel Abdeckeinrichtung mit Abdeckmembran
US5554188A (en) * 1993-04-29 1996-09-10 Xomed, Inc. Universal middle ear prosthesis
US5380328A (en) * 1993-08-09 1995-01-10 Timesh, Inc. Composite perforated implant structures
US5466262A (en) * 1993-08-30 1995-11-14 Saffran; Bruce N. Malleable fracture stabilization device with micropores for directed drug delivery
US5653760A (en) * 1993-08-30 1997-08-05 Saffran; Bruce N. Method and apparatus for managing macromolecular distribution
US5403321A (en) * 1993-12-15 1995-04-04 Smith & Nephew Richards Inc. Radiolucent drill guide
US6315788B1 (en) 1994-02-10 2001-11-13 United States Surgical Corporation Composite materials and surgical articles made therefrom
US5626611A (en) * 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US6074840A (en) 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US20020193338A1 (en) * 1994-02-18 2002-12-19 Goldstein Steven A. In vivo gene transfer methods for wound healing
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
DE4414675C1 (de) * 1994-04-27 1995-09-28 Kirsch Axel Abdeckeinrichtung für Knochendefektstellen und Verfahren zu deren Herstellung
US5681310A (en) * 1994-07-20 1997-10-28 Yuan; Hansen A. Vertebral auxiliary fixation device having holding capability
US5769899A (en) * 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
AU713540B2 (en) * 1994-10-25 1999-12-02 Osteonics Corp. Interlocking structural elements and method for bone repair, augmentation and replacement
US5609638A (en) * 1994-11-29 1997-03-11 Zimmer, Inc. Reinforced polyethylene for articular surfaces
AU3795395A (en) * 1994-11-30 1996-06-06 Ethicon Inc. Hard tissue bone cements and substitutes
US6376573B1 (en) * 1994-12-21 2002-04-23 Interpore International Porous biomaterials and methods for their manufacture
DE69625822T2 (de) * 1995-05-01 2003-06-05 Samyang Corp Implantierbare, bioresorbierbare membran und verfahren zu ihrer herstellung
CA2205231C (en) * 1995-09-14 2008-03-18 Takiron Co., Ltd. Material for osteosynthesis and composite implant material, and production processes thereof
KR100429937B1 (ko) * 1995-09-14 2004-08-02 타키론 가부시기가이샤 골접합재,고강도이식체재료및이들의제조방법
FI98136C (fi) * 1995-09-27 1997-04-25 Biocon Oy Kudosolosuhteissa hajoava materiaali ja menetelmä sen valmistamiseksi
US20050152950A1 (en) * 1995-11-13 2005-07-14 Saffran Bruce N. Method and apparatus for macromolecular delivery using a coated membrane
IL116477A (en) * 1995-12-21 2000-02-29 Hadasit Med Res Service Bone graft substitute and process for producing same
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
AU758844B2 (en) * 1996-08-08 2003-04-03 Trustees Of The University Of Pennsylvania, The Compositions useful in intervertebral disc reformation
US5964807A (en) * 1996-08-08 1999-10-12 Trustees Of The University Of Pennsylvania Compositions and methods for intervertebral disc reformation
US5718717A (en) * 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
EP0927011B1 (de) 1996-09-04 2003-01-22 SYNTHES AG Chur Zwischenwirbel-implantat
US6004323A (en) * 1997-02-04 1999-12-21 The University Of Iowa Research Foundation Surgically implantable fastening system
JP4467647B2 (ja) 1997-02-11 2010-05-26 ウォーソー・オーソペディック・インコーポレーテッド 骨プレーティングシステム
ES2299202T3 (es) * 1997-02-11 2008-05-16 Warsaw Orthopedic, Inc. Sistema de placas esqueleticas.
DE19706621A1 (de) * 1997-02-20 1998-08-27 Inst Textil & Faserforschung Bioresorbierbare wachsartige Zusammensetzung, ihre Verwendung als Knochenwachs und Verfahren zur Herstellung
CA2235655C (en) * 1997-04-24 2008-01-22 Sunstar Inc. Oral compositions comprising porous calcium carbonate
DE19721661A1 (de) * 1997-05-23 1998-11-26 Zimmer Markus Knochen- und Knorpel Ersatzstrukturen
US6113640A (en) * 1997-06-11 2000-09-05 Bionx Implants Oy Reconstructive bioabsorbable joint prosthesis
EP1007673B1 (de) 1997-07-30 2008-12-17 Emory University Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
US20050216059A1 (en) 2002-09-05 2005-09-29 Bonutti Peter M Method and apparatus for securing a suture
US6482584B1 (en) 1998-11-13 2002-11-19 Regeneration Technologies, Inc. Cyclic implant perfusion cleaning and passivation process
US20010031254A1 (en) * 1998-11-13 2001-10-18 Bianchi John R. Assembled implant
US7541049B1 (en) * 1997-09-02 2009-06-02 Linvatec Biomaterials Oy Bioactive and biodegradable composites of polymers and ceramics or glasses and method to manufacture such composites
US6977095B1 (en) * 1997-10-01 2005-12-20 Wright Medical Technology Inc. Process for producing rigid reticulated articles
US6136029A (en) * 1997-10-01 2000-10-24 Phillips-Origen Ceramic Technology, Llc Bone substitute materials
US6296667B1 (en) 1997-10-01 2001-10-02 Phillips-Origen Ceramic Technology, Llc Bone substitutes
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US7087082B2 (en) * 1998-08-03 2006-08-08 Synthes (Usa) Bone implants with central chambers
US6045551A (en) 1998-02-06 2000-04-04 Bonutti; Peter M. Bone suture
US20040081704A1 (en) 1998-02-13 2004-04-29 Centerpulse Biologics Inc. Implantable putty material
EP1067873A1 (de) 1998-04-01 2001-01-17 Bionx Implants Oy Bioresorbierbares befestigungselement zur chirurgischen behandlung von gewebe
US20060241763A1 (en) * 1998-08-03 2006-10-26 Synthes (Usa) Multipiece bone implant
CN1171928C (zh) 1998-08-24 2004-10-20 旭化成株式会社 聚酰胺树脂组合物及其制备方法
US6406498B1 (en) 1998-09-04 2002-06-18 Bionx Implants Oy Bioactive, bioabsorbable surgical composite material
US6398814B1 (en) 1998-09-14 2002-06-04 Bionx Implants Oy Bioabsorbable two-dimensional multi-layer composite device and a method of manufacturing same
US6350284B1 (en) * 1998-09-14 2002-02-26 Bionx Implants, Oy Bioabsorbable, layered composite material for guided bone tissue regeneration
US6200347B1 (en) * 1999-01-05 2001-03-13 Lifenet Composite bone graft, method of making and using same
US6136030A (en) * 1999-01-12 2000-10-24 Purzer Pharmaceutical Co., Ltd. Process for preparing porous bioceramic materials
KR100452410B1 (ko) * 1999-01-15 2004-10-08 퍼저 파마수티컬 컴퍼니 리미티드 다공성 바이오세라믹 물질의 제조공정
US6093201A (en) * 1999-01-19 2000-07-25 Ethicon, Inc. Biocompatible absorbable polymer plating system for tissue fixation
US6296645B1 (en) 1999-04-09 2001-10-02 Depuy Orthopaedics, Inc. Intramedullary nail with non-metal spacers
US6783529B2 (en) 1999-04-09 2004-08-31 Depuy Orthopaedics, Inc. Non-metal inserts for bone support assembly
US6187008B1 (en) 1999-07-07 2001-02-13 Bristol-Myers Squibb Device for temporarily fixing bones
US6447516B1 (en) 1999-08-09 2002-09-10 Peter M. Bonutti Method of securing tissue
US6368343B1 (en) * 2000-03-13 2002-04-09 Peter M. Bonutti Method of using ultrasonic vibration to secure body tissue
DE19940977A1 (de) * 1999-08-28 2001-03-01 Lutz Claes Folie aus resorbierbarem Polymermaterial und Verfahren zur Herstellung einer solchen Folie
FR2798059B1 (fr) * 1999-09-08 2002-03-22 Phusis Implant intersomatique, dispositif pour la stabilisation du rachis et kit pour la realisation d'une arthrodese
FR2801194B1 (fr) * 1999-11-19 2004-01-02 Fixano Implant de remplacement total ou partiel d'un os cuboiforme
FR2801191B1 (fr) * 1999-11-19 2002-02-15 Proconcept Dispositif de protection des nerfs apres intervention chirurgicale
US7771427B2 (en) * 1999-12-09 2010-08-10 Macropore Partially resorbable connective tissue distraction devices and techniques
DE50013602D1 (de) 1999-12-15 2006-11-23 Zimmer Gmbh Intervertebrales Implantat
US6893462B2 (en) * 2000-01-11 2005-05-17 Regeneration Technologies, Inc. Soft and calcified tissue implants
US6635073B2 (en) 2000-05-03 2003-10-21 Peter M. Bonutti Method of securing body tissue
WO2001060918A1 (fr) * 2000-02-16 2001-08-23 Asahi Kasei Kabushiki Kaisha Composition de resine polyamide
US9138222B2 (en) 2000-03-13 2015-09-22 P Tech, Llc Method and device for securing body tissue
US8932330B2 (en) * 2000-03-13 2015-01-13 P Tech, Llc Method and device for securing body tissue
US7094251B2 (en) 2002-08-27 2006-08-22 Marctec, Llc. Apparatus and method for securing a suture
WO2001070137A2 (en) * 2000-03-22 2001-09-27 Synthes (U.S.A) Multipiece implants formed of bone material
AR027685A1 (es) 2000-03-22 2003-04-09 Synthes Ag Forma de tejido y metodo para realizarlo
US6808527B2 (en) 2000-04-10 2004-10-26 Depuy Orthopaedics, Inc. Intramedullary nail with snap-in window insert
CA2414168C (en) * 2000-06-23 2010-02-09 University Of Southern California Percutaneous vertebral fusion system
US6875212B2 (en) * 2000-06-23 2005-04-05 Vertelink Corporation Curable media for implantable medical device
US6899713B2 (en) * 2000-06-23 2005-05-31 Vertelink Corporation Formable orthopedic fixation system
US6964667B2 (en) * 2000-06-23 2005-11-15 Sdgi Holdings, Inc. Formed in place fixation system with thermal acceleration
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
GB2371344A (en) * 2001-01-23 2002-07-24 Frederick Arthur Summerlin Blind rivet
US20020120340A1 (en) * 2001-02-23 2002-08-29 Metzger Robert G. Knee joint prosthesis
US7597715B2 (en) 2005-04-21 2009-10-06 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8123814B2 (en) * 2001-02-23 2012-02-28 Biomet Manufacturing Corp. Method and appartus for acetabular reconstruction
US6575986B2 (en) 2001-02-26 2003-06-10 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6743232B2 (en) 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
US6652585B2 (en) * 2001-02-28 2003-11-25 Sdgi Holdings, Inc. Flexible spine stabilization system
US6855169B2 (en) 2001-02-28 2005-02-15 Synthes (Usa) Demineralized bone-derived implants
US6827743B2 (en) * 2001-02-28 2004-12-07 Sdgi Holdings, Inc. Woven orthopedic implants
US7229441B2 (en) * 2001-02-28 2007-06-12 Warsaw Orthopedic, Inc. Flexible systems for spinal stabilization and fixation
EP1238637B1 (de) * 2001-03-09 2004-07-21 Co-Ligne AG Längliches Implantat
US7344539B2 (en) 2001-03-30 2008-03-18 Depuy Acromed, Inc. Intervertebral connection system
US20030003127A1 (en) * 2001-06-27 2003-01-02 Ethicon, Inc. Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
US6626950B2 (en) * 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US6512630B1 (en) * 2001-07-13 2003-01-28 The United States Of America As Represented By The Secretary Of The Air Force Miniature laser/amplifier system
US20050107795A1 (en) * 2001-08-10 2005-05-19 John Morris Bone plating system and method of use
US6653979B2 (en) * 2001-10-02 2003-11-25 Sierra Wireless, Inc. Antenna for a PC card
US20030097180A1 (en) 2001-11-20 2003-05-22 Pertti Tormala Joint prosthesis
CN1301757C (zh) * 2001-11-27 2007-02-28 多喜兰株式会社 植入物材料及其生产方法
US6719765B2 (en) 2001-12-03 2004-04-13 Bonutti 2003 Trust-A Magnetic suturing system and method
US20030220692A1 (en) * 2002-02-09 2003-11-27 Shapiro Irving M. Preparations of nucleus pulposus cells and methods for their generation, identification, and use
AR038680A1 (es) * 2002-02-19 2005-01-26 Synthes Ag Implante intervertebral
US9155544B2 (en) 2002-03-20 2015-10-13 P Tech, Llc Robotic systems and methods
US20040127563A1 (en) * 2002-03-22 2004-07-01 Deslauriers Richard J. Methods of performing medical procedures which promote bone growth, compositions which promote bone growth, and methods of making such compositions
US20040002770A1 (en) * 2002-06-28 2004-01-01 King Richard S. Polymer-bioceramic composite for orthopaedic applications and method of manufacture thereof
US7066962B2 (en) 2002-07-23 2006-06-27 Porex Surgical, Inc. Composite surgical implant made from macroporous synthetic resin and bioglass particles
NL1021137C2 (nl) * 2002-07-23 2004-01-27 Fondel Finance B V Steunelement voor bevestiging aan bot.
US20040054413A1 (en) * 2002-09-16 2004-03-18 Howmedica Osteonics Corp. Radiovisible hydrogel intervertebral disc nucleus
US7682392B2 (en) * 2002-10-30 2010-03-23 Depuy Spine, Inc. Regenerative implants for stabilizing the spine and devices for attachment of said implants
GB0302026D0 (en) * 2003-01-29 2003-02-26 Biocomposites Ltd Bioabsorbable implant
AU2003201614B2 (en) 2003-02-06 2008-02-14 Synthes Gmbh Intervertebral implant
US20050008990A1 (en) * 2003-02-26 2005-01-13 Therics, Inc. Method and system for repairing endosseous implants, such as with a bone graft implant
US20060076295A1 (en) * 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
ATE510605T1 (de) * 2003-03-14 2011-06-15 Univ Columbia Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung
US7819903B2 (en) 2003-03-31 2010-10-26 Depuy Spine, Inc. Spinal fixation plate
US7473267B2 (en) * 2003-04-25 2009-01-06 Warsaw Orthopedic, Inc. System and method for minimally invasive posterior fixation
US7067123B2 (en) * 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7497864B2 (en) * 2003-04-30 2009-03-03 Marctec, Llc. Tissue fastener and methods for using same
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20040262809A1 (en) * 2003-06-30 2004-12-30 Smith Todd S. Crosslinked polymeric composite for orthopaedic implants
FI120333B (fi) * 2003-08-20 2009-09-30 Bioretec Oy Huokoinen lääketieteellinen väline ja menetelmä sen valmistamiseksi
US7226482B2 (en) 2003-09-02 2007-06-05 Synthes (U.S.A.) Multipiece allograft implant
JP4095003B2 (ja) * 2003-09-12 2008-06-04 泉工医科工業株式会社 人工関節用中遠位チップ
DE10347232A1 (de) * 2003-10-10 2005-05-12 Bego Semados Gmbh & Co Kg Anordnung zur Rückbildung eines parodontosebedingten Knochendefektes
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
DE10348219A1 (de) * 2003-10-13 2005-05-12 Aesculap Ag & Co Kg Knorpelersatzimplantat und Verfahren zur Herstellung eines Knorpelersatzimplantats
US20050100578A1 (en) * 2003-11-06 2005-05-12 Schmid Steven R. Bone and tissue scaffolding and method for producing same
ES2379877T3 (es) * 2003-12-01 2012-05-04 Smith & Nephew, Inc. Clavo humeral con un inserto para fijar un tornillo
US7481839B2 (en) * 2003-12-02 2009-01-27 Kyphon Sarl Bioresorbable interspinous process implant for use with intervertebral disk remediation or replacement implants and procedures
US20080039873A1 (en) 2004-03-09 2008-02-14 Marctec, Llc. Method and device for securing body tissue
EP1789088A4 (de) 2004-03-24 2009-12-30 Doctor S Res Group Inc Verfahren zur durchführung von medizinischen verfahren zur förderung des knochenwachstums, verfahren zur herstellung von zusammensetzungen zur förderung des knochenwachstums und gerät zur verwendung bei solchen verfahren
US7887587B2 (en) * 2004-06-04 2011-02-15 Synthes Usa, Llc Soft tissue spacer
US8012501B2 (en) * 2004-06-10 2011-09-06 Synthes Usa, Llc Flexible bone composite
US7384430B2 (en) * 2004-06-30 2008-06-10 Depuy Products, Inc. Low crystalline polymeric material for orthopaedic implants and an associated method
US20060025848A1 (en) * 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20060089646A1 (en) 2004-10-26 2006-04-27 Bonutti Peter M Devices and methods for stabilizing tissue and implants
US9173647B2 (en) 2004-10-26 2015-11-03 P Tech, Llc Tissue fixation system
US9463012B2 (en) 2004-10-26 2016-10-11 P Tech, Llc Apparatus for guiding and positioning an implant
US9271766B2 (en) 2004-10-26 2016-03-01 P Tech, Llc Devices and methods for stabilizing tissue and implants
WO2006060416A2 (en) * 2004-11-30 2006-06-08 Osteobiologics, Inc. Implants and delivery system for treating defects in articulating surfaces
US20060149266A1 (en) * 2004-12-10 2006-07-06 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Anchor for screw fixation of soft tissue to bone
US7896921B2 (en) * 2004-12-30 2011-03-01 Depuy Products, Inc. Orthopaedic bearing and method for making the same
US7883653B2 (en) 2004-12-30 2011-02-08 Depuy Products, Inc. Method of making an implantable orthopaedic bearing
US7879275B2 (en) * 2004-12-30 2011-02-01 Depuy Products, Inc. Orthopaedic bearing and method for making the same
US7410488B2 (en) 2005-02-18 2008-08-12 Smith & Nephew, Inc. Hindfoot nail
US9089323B2 (en) 2005-02-22 2015-07-28 P Tech, Llc Device and method for securing body tissue
US8066778B2 (en) * 2005-04-21 2011-11-29 Biomet Manufacturing Corp. Porous metal cup with cobalt bearing surface
US8292967B2 (en) * 2005-04-21 2012-10-23 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8021432B2 (en) * 2005-12-05 2011-09-20 Biomet Manufacturing Corp. Apparatus for use of porous implants
US8266780B2 (en) * 2005-04-21 2012-09-18 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
FI20055194A (fi) * 2005-04-27 2006-10-28 Bioretec Oy Bioabsorboituva ja bioaktiivinen komposiittimateriaali ja menetelmä komposiitin valmistamiseksi
US7628800B2 (en) 2005-06-03 2009-12-08 Warsaw Orthopedic, Inc. Formed in place corpectomy device
FI20055304L (fi) * 2005-06-13 2007-02-20 Bioretec Oy Bioabsorboituva implantti, jolla on muuttuva ominaisuus
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8518123B2 (en) * 2005-09-09 2013-08-27 Board Of Trustees Of The University Of Arkansas System and method for tissue generation and bone regeneration
US8936805B2 (en) 2005-09-09 2015-01-20 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
EP1956998A1 (de) 2005-11-25 2008-08-20 Biomet Microfixation, Inc. Modulare prothese zur rekonstruktion des unterkiefers
US20080221594A1 (en) * 2006-01-31 2008-09-11 Hamman Ned M Resorbable truss
US7967820B2 (en) 2006-02-07 2011-06-28 P Tech, Llc. Methods and devices for trauma welding
US11278331B2 (en) 2006-02-07 2022-03-22 P Tech Llc Method and devices for intracorporeal bonding of implants with thermal energy
US11253296B2 (en) 2006-02-07 2022-02-22 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US8496657B2 (en) 2006-02-07 2013-07-30 P Tech, Llc. Methods for utilizing vibratory energy to weld, stake and/or remove implants
US20070224245A1 (en) 2006-02-08 2007-09-27 Northwestern University Poly (diol co-citrate) hydroxyapatite composite for tissue engineering and orthopaedic fixation devices
US20100305704A1 (en) * 2006-02-27 2010-12-02 Synthes Gmbh Intervertebral implant with fixation geometry
EP2010104B1 (de) * 2006-04-25 2018-09-05 Teleflex Medical Incorporated Kalziumphosphatpolymerverbunddstoff und verfahren
US9101505B2 (en) * 2006-04-27 2015-08-11 Brs Holdings, Llc Composite stent
US9155646B2 (en) * 2006-04-27 2015-10-13 Brs Holdings, Llc Composite stent with bioremovable ceramic flakes
US11246638B2 (en) 2006-05-03 2022-02-15 P Tech, Llc Methods and devices for utilizing bondable materials
KR100738476B1 (ko) * 2006-05-08 2007-07-11 주식회사 제노스 골유도재생용 차폐막 및 그 제조방법
CN101534917A (zh) 2006-05-22 2009-09-16 纽约市哥伦比亚大学理事会 采用萃取流体排出流过滤的微流无膜交换系统和方法
US9943410B2 (en) * 2011-02-28 2018-04-17 DePuy Synthes Products, Inc. Modular tissue scaffolds
CA2679365C (en) * 2006-11-30 2016-05-03 Smith & Nephew, Inc. Fiber reinforced composite material
US7718616B2 (en) * 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8480718B2 (en) * 2006-12-21 2013-07-09 Warsaw Orthopedic, Inc. Curable orthopedic implant devices configured to be hardened after placement in vivo
US8663328B2 (en) * 2006-12-21 2014-03-04 Warsaw Orthopedic, Inc. Methods for positioning a load-bearing component of an orthopedic implant device by inserting a malleable device that hardens in vivo
US8758407B2 (en) * 2006-12-21 2014-06-24 Warsaw Orthopedic, Inc. Methods for positioning a load-bearing orthopedic implant device in vivo
US7771476B2 (en) 2006-12-21 2010-08-10 Warsaw Orthopedic Inc. Curable orthopedic implant devices configured to harden after placement in vivo by application of a cure-initiating energy before insertion
JP5448842B2 (ja) * 2007-01-10 2014-03-19 バイオメト マニファクチャリング コーポレイション 膝関節プロテーゼシステムおよび埋込み方法
US8328873B2 (en) 2007-01-10 2012-12-11 Biomet Manufacturing Corp. Knee joint prosthesis system and method for implantation
US8562616B2 (en) 2007-10-10 2013-10-22 Biomet Manufacturing, Llc Knee joint prosthesis system and method for implantation
US8187280B2 (en) 2007-10-10 2012-05-29 Biomet Manufacturing Corp. Knee joint prosthesis system and method for implantation
US8163028B2 (en) * 2007-01-10 2012-04-24 Biomet Manufacturing Corp. Knee joint prosthesis system and method for implantation
US8617185B2 (en) 2007-02-13 2013-12-31 P Tech, Llc. Fixation device
US8435551B2 (en) * 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
CA2680586A1 (en) * 2007-03-26 2008-10-02 Mei Wei Electrospun apatite/polymer nano-composite scaffolds
FI20075246A0 (fi) * 2007-04-12 2007-04-12 Bioretec Oy Lääketieteellinen väline
EP2179030B1 (de) 2007-07-12 2013-09-25 Discgenics Menschliches bandscheibengewebe
CN101842062B (zh) * 2007-09-25 2013-04-03 拜欧米特制造公司 非骨水泥型胫骨托的制造方法
BRPI0820172A2 (pt) 2007-11-16 2015-06-16 Synthes Gmbh Implante intervertebral de perfil baixo
JP2008100112A (ja) * 2008-01-17 2008-05-01 Senko Medical Instr Mfg Co Ltd 人工関節用中遠位チップ
MX2010008591A (es) * 2008-02-04 2010-08-30 Univ Columbia Dispositivos, sistemas y metodos de separacion de fluidos.
CA2717725A1 (en) * 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
DE102008019748A1 (de) 2008-04-18 2009-10-22 Gottfried Wilhelm Leibniz Universität Hannover Bioresorbierbares Material
ATE554726T1 (de) * 2008-05-06 2012-05-15 Episurf Medical Ab Knieimplantat
JP5518066B2 (ja) 2008-07-30 2014-06-11 メシンセス リミテッド 前胃細胞外マトリックス由来の組織スキャフォールド
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US20100042213A1 (en) * 2008-08-13 2010-02-18 Nebosky Paul S Drug delivery implants
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
CA2734183C (en) * 2008-08-13 2016-11-01 Smed-Ta/Td, Llc Orthopaedic implant with spatially varying porosity
WO2010019788A1 (en) 2008-08-13 2010-02-18 Smed-Ta/Td. Llc Drug delivery implants
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
WO2010025386A1 (en) * 2008-08-29 2010-03-04 Smed-Ta/Td, Llc Orthopaedic implant
US9408649B2 (en) * 2008-09-11 2016-08-09 Innovasis, Inc. Radiolucent screw with radiopaque marker
US9642658B2 (en) * 2008-10-15 2017-05-09 Orthoclip Llc Device and method for delivery of therapeutic agents via internal implants
EP2346421A1 (de) * 2008-10-15 2011-07-27 Bioshape Solutions Inc. Vorrichtung und verfahren zur abgabe von therapeutischen mitteln durch interne implantate
CA2743247A1 (en) 2008-11-07 2010-05-14 Synthes Usa, Llc Vertebral interbody spacer and coupled plate assembly
FI20095084A0 (fi) 2009-01-30 2009-01-30 Pekka Vallittu Komposiitti ja sen käyttö
EP2400899A4 (de) 2009-02-24 2015-03-18 P Tech Llc Verfahren und vorrichtungen zur verwendung bindbarer materialien
EP2410929B1 (de) 2009-03-24 2019-06-26 Stabiliz Orthopedics, LLC Orthopädische fixiervorrichtung mit bioresorbierbarer schicht
US20100249944A1 (en) * 2009-03-31 2010-09-30 Thomas Jonathan D Multizone Implants
US8696759B2 (en) * 2009-04-15 2014-04-15 DePuy Synthes Products, LLC Methods and devices for implants with calcium phosphate
US20100268227A1 (en) * 2009-04-15 2010-10-21 Depuy Products, Inc. Methods and Devices for Bone Attachment
US9439685B2 (en) * 2009-05-12 2016-09-13 Bullard Spine, Llc Multi-layer osteoinductive, osteogenic, and osteoconductive carrier
US8888828B2 (en) * 2009-07-16 2014-11-18 Covidien Lp Composite fixation device
US9399086B2 (en) * 2009-07-24 2016-07-26 Warsaw Orthopedic, Inc Implantable medical devices
US9433439B2 (en) 2009-09-10 2016-09-06 Innovasis, Inc. Radiolucent stabilizing rod with radiopaque marker
DE102009054910A1 (de) * 2009-12-17 2011-06-22 Sgl Carbon Se, 65203 Faserarmierter Körper
US8475536B2 (en) * 2010-01-29 2013-07-02 DePuy Synthes Products, LLC Methods and devices for implants with improved cement adhesion
US8444699B2 (en) * 2010-02-18 2013-05-21 Biomet Manufacturing Corp. Method and apparatus for augmenting bone defects
US8715356B2 (en) * 2010-04-13 2014-05-06 Biomet Manufacturing, Llc Prosthetic having a modular soft tissue fixation mechanism
KR101145012B1 (ko) * 2010-06-25 2012-05-11 사회복지법인 삼성생명공익재단 스텐트
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
US9241809B2 (en) 2010-12-21 2016-01-26 DePuy Synthes Products, Inc. Intervertebral implants, systems, and methods of use
WO2012088238A2 (en) 2010-12-21 2012-06-28 Synthes Usa, Llc Intervertebral implants, systems, and methods of use
JP6342332B2 (ja) * 2012-01-24 2018-06-13 シンセス・ゲーエムベーハーＳｙｎｔｈｅｓ ＧｍｂＨ 圧迫ねじシステム
DE102012006454A1 (de) * 2012-03-30 2013-10-02 Heraeus Medical Gmbh Antiinfektiver Abstandshalter für Osteosyntheseplatten
US9539069B2 (en) 2012-04-26 2017-01-10 Zimmer Dental, Inc. Dental implant wedges
US9554877B2 (en) * 2012-07-31 2017-01-31 Zimmer, Inc. Dental regenerative device made of porous metal
US8920512B2 (en) * 2012-12-19 2014-12-30 Biomet Sports Medicine, Llc Method and apparatus for pre-forming a high tibial osteotomy
US10076377B2 (en) 2013-01-05 2018-09-18 P Tech, Llc Fixation systems and methods
EP2853384B1 (de) * 2013-09-27 2016-11-23 Skulle Implants OY Verfahren zur Beschichtung und eine beschichtete Oberfläche
AT515384B1 (de) * 2014-02-05 2016-04-15 Dietmar Dr Sonnleitner Vorverbundene mehrschichtige Folie zur Abdeckung einer Knochendefektstelle
US9867718B2 (en) 2014-10-22 2018-01-16 DePuy Synthes Products, Inc. Intervertebral implants, systems, and methods of use
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10376611B2 (en) * 2015-02-16 2019-08-13 The Royal Institution For The Advancement Of Learning/Mcgill University Multilayered bone graft and method of making same
EP3115025A1 (de) 2015-07-08 2017-01-11 Skulle Implants OY Implantat
US10058393B2 (en) 2015-10-21 2018-08-28 P Tech, Llc Systems and methods for navigation and visualization
DE102016211201A1 (de) * 2016-06-22 2017-12-28 Aesculap Ag Medizinisches Produkt, vorzugsweise zur Anwendung bei der Behandlung einer Knochenkavität, Verfahren zur Herstellung des medizinischen Produkts sowie medizinisches Kit
EP3740145A1 (de) 2018-01-15 2020-11-25 GLW, Inc. Hybride intramedulläre stäbe

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2412300A1 (fr) * 1977-12-21 1979-07-20 Serole Michelle Plaque d'osteosynthese mecaniquement identique au support osseux, destinee au traitement des fractures, osteotomies et autres traitements de chirurgie traumatologique et orthopedique
FR2439003A1 (fr) * 1978-10-20 1980-05-16 Anvar Nouvelles pieces d'osteosynthese, leur preparation et leur application
DE2917446A1 (de) * 1979-04-28 1980-11-06 Merck Patent Gmbh Chirurgisches material
FR2460657A1 (fr) * 1979-07-12 1981-01-30 Anvar Implant biodegradable utilisable comme piece de prothese osseuse
US4655777A (en) * 1983-12-19 1987-04-07 Southern Research Institute Method of producing biodegradable prosthesis and products therefrom
DE3414924A1 (de) * 1984-04-19 1985-10-31 Klaus Dr.med. Dr.med.habil. 8000 München Draenert Beschichtetes verankerungsteil fuer implantate
DE3479402D1 (en) * 1984-06-12 1989-09-21 Oscobal Ag Method of producing a bone replacement material
GB8415265D0 (en) * 1984-06-15 1984-07-18 Ici Plc Device
NL8402534A (nl) * 1984-08-17 1986-03-17 Gerrit Johannes Brinks Materiaal, geschikt voor toepassing als implantatiemateriaal bij mens en dier ter vervanging van afwezig botweefsel, alsmede werkwijze ter bereiding van het materiaal.
DE3671375D1 (de) * 1985-02-19 1990-06-28 Dow Chemical Co Hartgewebeprothese und verfahren zu ihrer herstellung.
US4842604A (en) * 1985-02-19 1989-06-27 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US4636526A (en) * 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
FI75493C (fi) * 1985-05-08 1988-07-11 Materials Consultants Oy Sjaelvarmerat absorberbart osteosyntesmedel.
WO1986007250A1 (en) * 1985-06-14 1986-12-18 Materials Consultants Oy Surgical device for immobilization of bone fracture
FI78238C (fi) * 1985-07-09 1989-07-10 Biocon Oy Kirurgisk osteosyntesanordning.

Also Published As

Publication number Publication date
CA1297795C (en) 1992-03-24
RU1769715C (en) 1992-10-15
AU8235787A (en) 1988-06-01
AU606903B2 (en) 1991-02-21
EP0289562B1 (de) 1993-02-03
FI80605B (fi) 1990-03-30
DE3784060D1 (de) 1993-03-18
FI864457A (fi) 1988-05-04
WO1988003417A1 (en) 1988-05-19
FI864457A0 (fi) 1986-11-03
FI80605C (fi) 1990-07-10
US5084051A (en) 1992-01-28
JPH01501289A (ja) 1989-05-11
ATE85225T1 (de) 1993-02-15
ES2005049A6 (es) 1989-02-16
EP0289562A1 (de) 1988-11-09

Similar Documents

Publication Publication Date Title
DE3784060T2 (de) Chirurgisches biokompositmaterial und dessen herstellung.
US4968317B1 (en) Surgical materials and devices
DE3664720D1 (en) Resorbable surgical composite material and method of producing it
ATE81019T1 (de) Absorbierendes material zur fixierung von geweben.
DE68924006T2 (de) Pharmazeutische Zusammensetzungen mit Eierschalenbestandteilen und ihre Herstellung und Verwendung.
ES2072975T3 (es) Mezcla de esterilizante y metodo de esterilizacion.
MX19953A (es) Procedimiento para la preparacion de nuevas benzo tiopiranilaminas, producto obtenido y composicion farmaceutica que lo incluye.
DE69116216T2 (de) Verwendung von Squalene, Squalane oder deren Mischungen zur Herstellung einer abkühlenden Zusammensetzung zur örtlichen Behandlung von Verbrennungen
ATE195072T1 (de) Verwendung von 6,7-substituierten-2- aminotetraline zur herstellung von pharmazeutischen zusammensetzungen zur behandlung von septischem schock, und antipyretischer und antientzündlicher zusammensetzungen
DE68926222D1 (de) Verwendung von 1,2,3,4-Tetrahydroacridinen zur Behandlung von AIDS, sowie Verbindungen
DE3888538D1 (de) Orthopädische Stütze und Material zur Herstellung derselben.
Court-Brown Antibiotic prophylaxis in orthopaedic surgery
PT84619A (de) 2,4,6-tris-tertiaerbutylamino-1,3,5-triazin zur prophylaxe und behandlung von epilepsie und angstzustaenden verwendung dieser verbindung zur herstellung eines arzneimittels sowie arzneimittel auf basis dieser verbindung
ATE100074T1 (de) Kunststeine, verfahren zur herstellung und verwendung derselben.
DE3765250D1 (de) Verwendung von 24,25-dihydroxycholecalciferol zur behandlung von harnsteinen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition