DE3855055T2 - Chemische Blockierung durch Phosphithylierung während der Oligonukleotid-Synthese - Google Patents

Chemische Blockierung durch Phosphithylierung während der Oligonukleotid-Synthese

Info

Publication number
DE3855055T2
DE3855055T2 DE3855055T DE3855055T DE3855055T2 DE 3855055 T2 DE3855055 T2 DE 3855055T2 DE 3855055 T DE3855055 T DE 3855055T DE 3855055 T DE3855055 T DE 3855055T DE 3855055 T2 DE3855055 T2 DE 3855055T2
Authority
DE
Germany
Prior art keywords
phosphithylation
oligonucleotide synthesis
chemical blocking
during oligonucleotide
during
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3855055T
Other languages
English (en)
Other versions
DE3855055D1 (de
Inventor
William Alexander Andrus
J William Efcavitch
Lincoln John Mcbride
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lynx Therapeutics Inc
Original Assignee
Lynx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lynx Therapeutics Inc filed Critical Lynx Therapeutics Inc
Publication of DE3855055D1 publication Critical patent/DE3855055D1/de
Application granted granted Critical
Publication of DE3855055T2 publication Critical patent/DE3855055T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C07F9/142—Esters of phosphorous acids with hydroxyalkyl compounds without further substituents on alkyl
DE3855055T 1987-06-04 1988-06-02 Chemische Blockierung durch Phosphithylierung während der Oligonukleotid-Synthese Expired - Fee Related DE3855055T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/058,179 US4816571A (en) 1987-06-04 1987-06-04 Chemical capping by phosphitylation during oligonucleotide synthesis

Publications (2)

Publication Number Publication Date
DE3855055D1 DE3855055D1 (de) 1996-04-11
DE3855055T2 true DE3855055T2 (de) 1996-09-19

Family

ID=22015191

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3855055T Expired - Fee Related DE3855055T2 (de) 1987-06-04 1988-06-02 Chemische Blockierung durch Phosphithylierung während der Oligonukleotid-Synthese

Country Status (4)

Country Link
US (1) US4816571A (de)
EP (1) EP0294196B1 (de)
JP (1) JP2787774B2 (de)
DE (1) DE3855055T2 (de)

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Also Published As

Publication number Publication date
EP0294196B1 (de) 1996-03-06
EP0294196A2 (de) 1988-12-07
DE3855055D1 (de) 1996-04-11
US4816571A (en) 1989-03-28
EP0294196A3 (en) 1990-09-12
JPH01100194A (ja) 1989-04-18
JP2787774B2 (ja) 1998-08-20

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